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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP28</accession>
    <name>A0A6A7BP28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_19758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006068">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <dbReference type="EMBL" id="KAF2857094.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13658" checksum="5414811CACCAABA0" modified="2020-06-17" version="1">MLDQKGADIMFELGLPFVLFDNPKFRDWITSLNPEHSLPNSKQLAGPMPNASYERLKQRVSNVLFEGEERKRLTLVTDSWTNQRNEPLSNNLLATPDGQSFFYKAVATEFNPHIGAYLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPE3</accession>
    <name>A0A6A7BPE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_301469</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857236.1"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="143"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="1484"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1564"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2168"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="898"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1323"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1679"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1749"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1923"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1998"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <end position="1606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="236"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857236.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="2221" mass="253296" checksum="AC506B2489B8031B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQE9</accession>
    <name>A0A6A7BQE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="PEPSIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="340"/>
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        </location>
    </feature>
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        <location>
            <position position="40"/>
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    </feature>
    <feature type="active site" evidence="5">
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            <position position="233"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857454.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BQJ9_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="21691" checksum="9C9B9FDCD68D9094" modified="2020-06-17" version="1">MKATSMLRGLMPDLVRPRRGVQAFDLGCGRPVLISGCVCRFMADNSAAAALCSIHWTGGQPCHDYYWRWTAVSQWKDIIDVSSLRVLRHTKGLPAKEADLVGIEHPLTELYRLKGFDPHQDFTYDMLHSLLLGVIIYPWLDTLNLPVIKEKLLEACNSCTFSRKGRLCDIPLTRQIANWNKSFTGGGFRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BQT7_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857135.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="292" mass="31906" checksum="2D91003ABE3E10B2" modified="2020-06-17" version="1">MLSPPASANAGTLHYIPARLSAFELGASKANTLIWIAGLGDTQLFVDYPKALSTALALSNWSVAIANLHSTGLGWGISSISRDANDLSKIVAYFRSHKPGGKIVLMGHSTGCQDCMEYLLRKNETVEGVILQAPVSDREAMAMGDQNLVKEANEAATRMNPEDVLPHRLTRPLFGRVAISARRWLDLSSPEHNGADDFFSSDLSDEQLENTFGSIKTPLLILYSGKDENVPDFVDKEALVQRWLDIVRHGDGEAQGRIIPSATHNLNGSDRKVVGELVNFVVSFLHNKESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRH0</accession>
    <name>A0A6A7BRH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRH0"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="466" mass="50911" checksum="543531113B6D6289" modified="2020-06-17" version="1" fragment="single">MAPGAVRRNDSSTGSLLETSCRLRNPDGSKCRKRCLGDKRFRSMQEHIRRAHPEYYIPRLPATEESIERMCSSTPAPPPATHSNTLAMVSMSSPNPRAELMTQPFQQYAHPSYYTPDTDAVAIFNNMQEQQRRQDYRRGSLLPDASAAAVLAELHYHRPDNQWADHDLGQGTTFASMQLSPPSAETEHVQGFFQPRNGELRPTRFRPDASLQGGTYLRQSPFASTTPETPAMVAPTLPRPLSRLPATRSRRLKGKKDKRPLSEPNGNFMSQDKRWHELLDAATSATEEGGDESREPTPNPASSLNSPPASQSLLPPFQPFTASPLQHALTPPSPDVPLPYSVASPSPNHTASTSPHFGATNVGNSPIFGHEAIQPTPETINPDSMLPNAIQPLDSGGFSTDGPTIYCSGCRRGNPLKDSFACTNCICGLCGDCVEAIITGQSRGKESGCPRCTSYDSLFKPFQLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRK5</accession>
    <name>A0A6A7BRK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_223215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRK5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14579" checksum="0035A4BF4FFF6902" modified="2020-06-17" version="1">MRSPTGLFIFEGFYRHVSGKFHHVHLGGILHNGRYGILQKLGCGSFPTVWAVRDEQEQRYVAIKIPIADAPSSFETSVLELEGPNGIHSCTVTDIYGDPVGLDLEEEKFALKASAARRHQKHLPQAIDCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRM8</accession>
    <name>A0A6A7BRM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_266492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRM8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="26002" checksum="888DD5FA33B8FDA2" modified="2020-06-17" version="1">MAPKLEINSNTLDHVSDSWPLYELKTHRKLVLVTRDERRDSIYVEVTPCSESSTTCWRSGNMYAISCLCLCTDQLFVSLYDITCLLGFLQRRSSDVFSISKIWPLLKAAEPMPGHDSRFHNWDLSGFALDLQTYRCLPDNHVPMGYDFIPWRDLKVYLEKGFNAYDQLTTCVRSIDPGDLSRREAFVWFTSVSPPSQAQHGEGSDRTMNFVENHQQQVPSHSPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX0</accession>
    <name>A0A6A7BRX0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222279</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF10">
        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46382" checksum="FD10C683D838FC6F" modified="2020-06-17" version="1">MAEVAAGLWAAEEAVSTTVQLGIGAYFLSKPTQPLKAVFLQIATSEDDETRNSLCRSDHTLTVIDNRAYIFGGQTATEKLASAEMHAVTLMSKDAPQPDYSVIPAIPAKEGGKLPSPRRKHAACAFNGCVAVFGGLDEDGKVIDEGHGIWLFNGTKSAWETVEPADDPKHGPVPRSSATLLHHQSGMILCGGQDASGAGLKDVWLFDYVVRAWSRLPDAPVVHTNASVSSGVLHVISSVDNMSGDLHILQITPKEGEEHKWHTVTFPTNPLTPGPRPRAGAGLLPVTTGYGRHYLLYILGARQDASSPVEAQTEPPEVHPESAEEPKYWSDVWTYQLPSSQVKPTSITDSFKPAKIKDSIRSALGYDSGQHSWAEVEVLPPTDMQLGAGKVHPGPRGFFGCDVMADGQSVVIWGGVNAKGEKEGDGWIIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX3</accession>
    <name>A0A6A7BRX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_283548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRX3"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="138" mass="15682" checksum="EA68B37D65FF140B" modified="2020-06-17" version="1">MAATEPHDQTTVFVQLDEYPWQDDAEFQSGLRSILGSANNHDAAQIEKLTLRAKCFYHARKNGVPVDHEAYKQWVEDGRPNTTEKDDRRSFAEICDMVVCGRPVPGIKEIPDTVLVGKASESRAEKRRKPWEKTQPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA3</accession>
    <name>A0A6A7BSA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA3"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="49064" checksum="C52DB949FBA1A9CD" modified="2020-06-17" version="1">MSTNKRRKLTPMTSLAKNTPSTQPYRMMIPQAGPHRYTHIHTHQAEQWLLGASPLFTKSEGEMSQYQTCLFHDPGTDLIVHNHSNTSSKNNTSPVAPPTKPSPPQSTPKSTNSMPPKKKLTLASYKSKRKLAAEQTPQPQDAAQQHAEESTPHNPPKRSSSSIPDLPPKLTPLPTDPILSSPLSSTLPDNITKTLDHFTRQRLLMQQERLEGLGKELKHSSTAHSEAGNPTLAALEAVESLMAFMLAFVCCEEALHVKKKGEGGRERGGRGDGGRDERDAPSQRDPLTPRDAPPQAPKTSCPALKNWHSLSNYLPFVSAKCEAFPLLHGLMAHLFVSVLAHILSIEPDGKSCAKLVRCVDLADRELGLEVLMDQFGAVWDGRVKDFGECVVDKWGFGDGRFDGKYRLPVGAHLKPVLAVRAGMRILEAWVGKYFDEGGYMFRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA4</accession>
    <name>A0A6A7BSA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPC2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_252562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA4"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
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            <end position="344"/>
        </location>
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    </feature>
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        </location>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="438" mass="46145" checksum="D993894C8609151B" modified="2020-06-17" version="1">MAMPPPENFLSLPQPPPLLSNGVPIDEASTEKAKRPRKKKEGDGLVKDKKPRKPREGSGVPRKKQKLEEQSAQTIPHMLPSPAQPRPPQPMGAPPSAPPTLWPHSSGQRYDPVRAAVVNRASASPSIASLIDPPHVSPPPIQMQPLTTAATSTPAPAPAPAPAPVLGDGAMDLDKPKTPSSTHSSANLPKKPRAPRPAGSGLLTNSIWGEQAKATERPGVSINLNIPLDRAGGNSVNIAQEIVKKYGQDAINPRAAAHRRDLLRTQAAANALDAGSDDVDSTSDIGEDSNAEPAGVDEGEKPRKRRKKVEEYDKEDDFIDDTELAWQNQAAVAKDGFFVYSGPLVPEGETPKVEPSQGTGRGGRGRGRGRGGRNAAAGTTHGASAEASKPTVTATRARGRAKGTTAPRKPRTTKADRERIEAEKATAQPQATGPVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSB6</accession>
    <name>A0A6A7BSB6_9PEZI</name>
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        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
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            <end position="172"/>
        </location>
    </feature>
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        <location>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="346"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="617"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
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        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="860" mass="97156" checksum="B5541BACBC23CAD8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSE8</accession>
    <name>A0A6A7BSE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
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    </feature>
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        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="26218" checksum="5462D16AB17C00E7" modified="2020-06-17" version="1">MATTAPKPSSSVKLVLLGEAAVGKSSLVLRFVSDTFEANKEPTIGAAFLTQKCQLPERTIKFEIWDTAGQERFASLAPMYYRNAQSALVVYDVMKPASLVKAKHWVAELQRQAAPGIIIAMVGNKIDLCEEADEEDEDAAQGGDESDAQVQEGSGGDASSVKRKVSREEAEQYAKEEGLLFFETSAKSGHNVNEVFTAIAHKIPEAKPKESRMAASSATQNTNIGDRIDLNSRSGGTSKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT02</accession>
    <name>A0A6A7BT02_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_272398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3854292at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="382" mass="43776" checksum="C5C20D4F6938CBCC" modified="2020-06-17" version="1">MDWRSLAAEQKRQIDELNTALERLNPQLTEKSKQINELRFRLAEQGDCVSDGELKAKLREAENHIAELRQHISTQECQYVEQQRKLEEQQQSSTQIVSLRQQIAGLTRQLQAEKKNNTKYLFAPGKVIGNDDEDDEEPNVRTTMASSRALTIWHPPSRADRRNAAVAFPSPTRANSKRKRSLRAPRHARQKAAKRRYIKREDEDEDEEEEEEEEEEEEEEGEEEEEEVHSERQRSISRSISFNEAKHNTAEAAESESSRRITRGRTKPAAPSTLAPFHFLAVVSYDEEGDVDEYFDSELDFDDCMEELWEHVAILRDRWESRKGQDWSWEFEKPGELGGGLAAKANTPAWTASSAEDLVSPTLSQEKNGTSSSSLCTTKIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT07</accession>
    <name>A0A6A7BT07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_221503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="786951at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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    </dbReference>
    <dbReference type="SMART" id="SM01173">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
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        </location>
    </feature>
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            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="34230" checksum="8CE90FFF550C1441" modified="2020-06-17" version="1">MADEEDDYLSMSFAEEPKRPETSLQRVSRLKREARDRGRIMSKKERAEMEEITREIALATPLDTSTNKGARMMAKMGFTGGALGKSEDGNARTQPLPVQLKNDRGGIGVESEKKKRIRDLAGNLEQGFKRQKMDEQSFRERTREEHEERRAEGQMWRAMRTLESFESEDGEVKDSVPLKAINLYWRPLVKQRREKEGASRRIAPLRNEDSDSEDEDGALSKTLNGGEDALQGVVDEDDDDDPELEEFEALSFAERLERIVFEMRHKYHYCFWCKHRYADDKEMEECPGQTEDEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTP1</accession>
    <name>A0A6A7BTP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_251187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTP1"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="18232" checksum="5538026C5E0740E3" modified="2020-06-17" version="1">MSTDHLFRISLPPILTSHTRAIGVYTSGALFSISLFSLLDASLWSSSHLNGSLFHVTFLDWVPAIFSFLGLIIINLINKDHLLGEGAGYGDENHQWRLRVWLFVGFAALAGGLAGGVAVLVLKYVTKGAEWPALGMGVEGLLANAGVMLACVILWTAQRGDEFGYNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUI5</accession>
    <name>A0A6A7BUI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_220239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUI5"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="415"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="604" mass="67285" checksum="46DEDB05F74CE962" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV97</accession>
    <name>A0A6A7BV97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="117"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="232" mass="25945" checksum="559DDA0F7D37AA11" modified="2020-06-17" version="1">MPKSKRARTVHTSKVAKKKGLKIAVWTTVLENAQQYSHIYVLSVRNMRNSYLKEVRERFRDSGKIVFGGVKLAAKALEEVNIPLSPYLKGDVGLLFTEETPGDVLGFFDTFVRTDYARAGHVATRTVTVPKGVVYSRGGEIDVEDDTPVPHSIEATLRKWGMPTKLSKGRVMLDQEYTIVEEGKVMDSNQTALLKMFGIVMADFKVGVVAYWNRDIKSVVQIKGAEDVMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVB1</accession>
    <name>A0A6A7BVB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_296220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVB1"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF422">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="66"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="52375" checksum="895D063AB9F527BD" modified="2020-06-17" version="1">MTHVGTSRDSRTLLTKRHTVLRERFLCQPRQLPAVVGKANAVDAQVMGNSSGKPVVVTDEVSLGHFRLLRVVGKGAFGKVRIVERKDSGLTFALKYIRKDEVVRRDNVRNMIRERRMLQQLDHPFLCNLRYSFQDADYLYIVVDLMNGGDLRFHISRKTFTEEAVRFWVAELACALRYIHSQGVVHRDVKPDNALVDAEGHVHLADFNVAAEYTPGKLLTSRSGTLAYLAPEVYARRGYGCEVDWWSLGVLFYECIYNRRPFEGDSQNALAEVIARANPSYPTTSPPVSEPCLHAIRSLLEKDREVRIGAAGFETFTNNPFFRPIDFDALERKEIEPVFCPSSSKANFDATYDLEELLLEDAPLEARSKKPKQRPELRCGASRQEIRADELHRMIETMFEPFDYTAARGTRSSSVPAVYNVKARKHKTSNASSARTCPSTTGSPASRTRTSGTRFGDPTPANPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVD7</accession>
    <name>A0A6A7BVD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1752-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVD7"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3295" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="141" mass="16007" checksum="0106CDCAEE7EF769" modified="2020-06-17" version="1">MMHESDRAAALRNAASQPALNGRRRASPPMDPSLPTVSETETGPRPITIAKAPSNASLALSPRTTRRNMLSTELTESLRKNLLWERQYRSTSNLMKMKRRHTTQDMTKLRQLPEPVTLGANRQFTNEYFDAGLQEYHAKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVM0</accession>
    <name>A0A6A7BVM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_259015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVM0"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    <sequence length="1356" mass="151072" checksum="58EA691C9030E671" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-mannitol + NADP(+) = D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16767"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="5"/>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW35"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="357" mass="38423" checksum="F983F64819163BB2" modified="2020-06-17" version="1">MQSKFLTTARAAATSRRIPSLVISRTFASRPALLKDDGHDKYSTASELGAHEDEGRFSRTDKNIRVEYPKEEELPRSQPVRGRGGSHSLRTLASFSLEGRVGVVTGGARGLGLVMSQALVASGANVALVDMNEELAIRQAKQLVETFHAENPGTTESPKVTAHYADVSSPESIDAAVTSILKEHGKIDNLVTSAGFTENFDATMYPPDRMRKLWAVNVDGTYLFAVAVAKHLMERKSAGSMVFIGSMSGAIVNVPQPQAPYNASKAAVRHLASSMAVEWAHAGIRVNCISPGYMLTPLTKKILDDNPELAQKWISLIPQGKMGRPEDLMGAVTFLCSDASSYITGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW38</accession>
    <name>A0A6A7BW38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_249400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW38"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35807" checksum="95AEDB25ADF01BA9" modified="2020-06-17" version="1">MSSPPPFLSLIQGINDYVPDSAYYYSLYLPLSSVPHGVLLPNIISLVPWTPSFHISHTAPRTITLTAPPNTPADKTPEYITSTLAEVVNKCIESGKFDLFCGKHSELVTIPTYTHGKVTIERFATALFGIQTQGVYAIAFTSTHAGNKCTRDPSSAAAELTPPNEPAKKPTLFIPRRSAYLYTYPNFLDATIGGGMQSTSTPFSCLLAEGEEEASLPAHLLQQHAKEIGTLRFTNLTGRGFSGEQGLVCPCELFLYELDLTGTGYVPRENDEEVEVFHEMGVEEVKERLGRGEFAPAAALVVLHWLVRGQFVELEGEVRKIWEGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWB5</accession>
    <name>A0A6A7BWB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_282644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="13"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWB5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000062">
        <property type="entry name" value="Calcium/mangenease P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
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    </dbReference>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2859510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="967" mass="104234" checksum="C6867AA890FAF85C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG6</accession>
    <name>A0A6A7BWG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWG6"/>
    <dbReference type="OrthoDB" id="3944494at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="11803" checksum="816372175D4BE068" modified="2020-06-17" version="1">MHKGAVRLAEDLGAPALDCFRSASPGYGGNHRNAFMEGHVSLVTSYRKGFSVTGSTKLLHRFLPRSFRRDYGETDAMNQQAGHSGALTPVRLEKCPAMSRREEPSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWN2</accession>
    <name>A0A6A7BWN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_258783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="120" mass="13737" checksum="3E405F1BB1853A43" modified="2020-06-17" version="1">MPAIRGQNSKRKARRHAAIRAIDQIHADKISKKHLQQYHDTKAREGLPAYGQFYCIECAKWFESEANLQKHAKGKPHKRRLKQLKEEPYTQKEADAAVGLTTDNGREAKDDVDMAIDDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWV3</accession>
    <name>A0A6A7BWV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_277670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWV3"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025452915" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="447" mass="48959" checksum="D8CB0DA297BF4D04" modified="2020-06-17" version="1">MRRIAILPPPLLALLASTAVAAVEPVAVDIKTIQNVTCSRPSRNGDTLAITYTGRLQSDGTIFDQNTSHERAFTFTLGENRVIQGWEQGLRAMCPGERRILTIPPELAYGDAATGAIPPNSTLVFEMELVDVVGVKQEELVFGPSTTATAVAAGIASDDEDDGDRKQAECRLLGPFALLVQAALGAVALLTLVWKRYRETPKRPWKIWIFDVSKQVIGSAILHVLNLAMSMLSTTDLMAASAKPDAEGRTPNPCSFYLLNLGIDTTVGVPVLYILLKILHALFLKTPLAQPPESIKSGNYSRPPRVTWYLKQLLIYSIGLVGMKLFVLFLFTILPWLPWIGDWALRWTNGNEALEITFALFIFPLIMNAVQYWIIDSFIMDKQRSASGGKGYEAVGQGDPHANGGAGGYDDDRDDDYDDDDDDARKGSAQVDEAPLNEVDPTPIPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWZ1</accession>
    <name>A0A6A7BWZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_108608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWZ1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="119" mass="13340" checksum="DC9ED97509FCC015" modified="2020-06-17" version="1">MYTIEPGLDLYQVRDDHKNDNKDEEESTKSTERCKRRCGCMCILAIFLLDIGSLSAIVGLRLSTDKGNAKRAKLAHPEPLTISEKYILDTFSSTTSNFSRARTLLMALPSPDPPKGHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWZ8</accession>
    <name>A0A6A7BWZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_218534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWZ8"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="61"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="241" mass="27502" checksum="72B918F23A936D41" modified="2020-06-17" version="1">MDDQDTSTNTLDRDVPTPNSLNSKPPTDLNGLSWPSVGTHQRLQEQEQPREAEERLKKLAGAVRTILECIGEDPDREGLRRTPERFAKAMMFFTQGYEENLRDITNNAVFEEDHDEMVIVKDIDIYSLCEHHLVPFAGKMHIAYIPSTSRRVIGLSKLVRIAQMFSRRLQVQERLTKQVALALSEALEPQGVAVVMESKHMCMVMRGVQNASAWTTTSCMLGVFRKQAKTREEFLSLINRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BX37_9PEZI</name>
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            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025543851" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
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            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10987" checksum="DD24069B9F661BC5" modified="2020-06-17" version="1">MALSPFLLSLKWVVLGSWLSRLDHGHEAPCPCIIGLNCCRIAIIWNTCSCINENACAVSFANGCEADNSALYSYGYCRCRWWHGRSIDPNASEACQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BX65_9PEZI</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08799">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
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            <end position="326"/>
        </location>
    </feature>
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            <end position="368"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="521" mass="57319" checksum="9169948AEEDBDBD7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXE0</accession>
    <name>A0A6A7BXE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EMP24-GP25L family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_92891</name>
    </gene>
    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025492569" evidence="10">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="24052" checksum="839F68E89739EA94" modified="2020-06-17" version="1">MLFHRVALGLLGLLVCGSVATSLTYKLAPNDKECFYAQVDKPGAKVAFYFAVQSGGSFDIDYTVFGPSLEPRKDKVISDGQKERQGDFVFTAERAGEYRFCFDNTMSTMSEKLVNFEIAVENEPRSQIPQKAGATPEQLSGVEETILKLSGEVSSLIRHQKYFRTRENRNFSTVRSTEKRIFNFSLVESALMVAMAGLQVFVVKMFFTGGRKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU9</accession>
    <name>A0A6A7BXU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_264913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXU9"/>
    <dbReference type="OrthoDB" id="3780939at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="12052" checksum="FC595254435583B2" modified="2020-06-17" version="1">MDAHCKFEFWGIQIYAAIDQFFPRVMWIYVGISSRSAVPVSNQYISMLASDALPGREFARGGPGRPPSDGRLRQVCILPRSEPHPTIINLCKVIVRVPALQAGGRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXY2</accession>
    <name>A0A6A7BXY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_218233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXY2"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="11">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="10">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="451" mass="50980" checksum="64E86189207E8697" modified="2020-06-17" version="1">MRQIQYLDRVAAVEIPAVAMSADERDEKEMLRASLEGIIQQVCSAHPKSLPPVYLQCFGSFVSGFATAGSDMDLVTVLPDGDPHHACFSLMENDLPRVLEKRLLELGYGARLLTRTRVPIIKVCEKPGEVLLGKLREERERWDVLPDEEKYPHLHPLSPDVNVQAEQGNDANPAAGQERKLKVRLEAKPFTRERKAGPLEFVGNVGIQCDVNFFNPLAIHNTQLLKCYSACDARVKPMVLFIKAWAKRRKINSSYSGTLSSYGYVLMVLHYLINIANPPVLHNLQGPWRPSMPCTPPGATRVIVDGWPVDFWSNEVEIAWAAQNKMMTTNTEPLGSLLTGFFDYFSSQNGSLRYNWMQDVISLRTHGGILRKDKKGWTKAVTEESNNRKVHHRYLLCIEDPFELTHNVARTVTHYGIVAIRDEFRRAARILHNVGQNRPCIDGELLAQMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY61</accession>
    <name>A0A6A7BY61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY61"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <position position="81"/>
        </location>
        <ligand>
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        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="287" mass="31413" checksum="403686E47D76067A" modified="2020-06-17" version="1">MDQNRAIRMLRASSEGKYGILGVVSYNVETILGAIAAAESKKSPIQILLFPWAFQKFRILVDVAAQAARRASVPVTVHMDHAQDPDVVRAAAAYDAADGTPAFDSIMVDMSHYDKEENLARTRELVAVCRARGIATEAEPGRIEGGEDGVQSIDSAVMTTAEEVDDFVGTGIDFLAPSFGNVHGNYGGKIQLDFERLRTIRDKANGRVQLVLHGTNEFTPEIMDECVQNGMTRVNVNGLVLDKYYEFIRESAGRVPMTQLMEKGVSLIKESCEEWINHLGCSGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY66</accession>
    <name>A0A6A7BY66_9PEZI</name>
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    </protein>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="282"/>
        </location>
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            <end position="553"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="584" mass="64416" checksum="1B80EE6CE7EAD745" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY91</accession>
    <name>A0A6A7BY91_9PEZI</name>
    <protein>
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            <fullName evidence="1">HAD-superfamily phosphatase</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGPP1/Gep4"/>
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    <dbReference type="NCBIfam" id="TIGR01662">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
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    </dbReference>
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        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="22405" checksum="6C999E2330371CF3" modified="2020-06-17" version="1">MNLSGSAHFFRLFTNPSLCLPHYTIHTFDQLPVPLFPEKDIRAIILDKDNCFAQKKTNTIHPPYRQKFEQLRAAYPGNKLIIVSNTAGSGDDPSLTDAARVEKATGVAVLPHSTKKPGCGVEVLKFLREADDVGITSPSQVAVVGDRLFTDVMMANTMGAHAVWVRDGVVEDRGLLTRVEKGLERFLTRRGYVPPDPRSQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYJ6</accession>
    <name>A0A6A7BYJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_257877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
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        <property type="reaction ID" value="UER00597"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:thiamine binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:thiamine metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
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        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="171"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="26670" checksum="06A92F5113C41CC9" modified="2020-06-17" version="1">MAVLRPGDMFAAESDTTALLILNCPIQGVGMLRKLHANVGYCICADGGANRVYDILMEEYGERGWRDALKVALPNEIHGDLDSIEGMVRERYAALGVRITKDGDTESTDFGKCIDILRERVDGLRDVVVLGSLGGRVDQGLGLVGELLRVAGKVRVWLVTERSLSFVVHPGETTVELGEWKRGSHVGVLPVYGPATLGTHGLKWDVTAWETEMGGKVSSCNMLAADRVVIQVNREVLFTVELAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYK0</accession>
    <name>A0A6A7BYK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_282507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYK0"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49360" checksum="541C759D94CDC152" modified="2020-06-17" version="1">MPAFTGNKWWKRQRYHVWSVYRRLMVLVIAANFGAIVAMIVRCVRYPGTFTSAEASTAVGANLVAGILMRQEHVINTFFHIAILQPRWFPAWLRRTIAKFAFHYGGVHSSAGISAIAWYIFFLVLLPLTFPGTRTESILMVALSAIVLVLLLVIAGMSHPRVRNAHHDLWELSHRFGGWSAVAVFWIQTMFSAVVAARVADLPLGRVLIKTPSFWFLIIITWCLIYPWLWLRKVPLEAVKLSNHAAELRFTHSNIGTCRGVRLSHNPLIETHAFAGIPHCPLEGDLEKGYSVIVSNAGNWTTDMIQNPPKHIWCRGVPTLGVMRLSSLLSPIIIVATGSGIGPCTSFLNVFPHHRARILWVARDPLKTYQSGLINRVRRIDPNAVIVDSTRTGKKSVPALTYALVKETKAEGVMIISNPKATSETVEAMESRGITAFGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG6</accession>
    <name>A0A6A7BZG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_217824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZG6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21075" checksum="A6CDA173C8810181" modified="2020-06-17" version="1">MYRPGIPSPATRELPMPNISTITSLNQAHATLLHCWNQLARFVRECVAGPLPPPAVTALEERRQHFSAWLNQWENAFKQFLCITRASMDSEQLTLSRVLKANHLCCYIMTSIAGRPPTVADTFEAEFRAIVDLCGAVFYARSLSPRPPPAVEPIAAGLDVQSPLHVVAAQCRNTDISNRAREMILHQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZK2</accession>
    <name>A0A6A7BZK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZK2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="91" mass="10114" checksum="A5402E5F40C0C897" modified="2020-06-17" version="1">MTFLTKVSWRAKLQLILNQLFFRPCGGDEEFKRPVDLCLHIGAGCYALAEVAQRLAITPASSVPSEPAFSILSLIHNSLKNLLLTPKFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZM6</accession>
    <name>A0A6A7BZM6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_264769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZM6"/>
    <dbReference type="Proteomes" id="UP000799421">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="16857" checksum="AA0F44D81DDF4155" modified="2020-06-17" version="1">MTTGGWSPLTNNNNNNNNNSNNNINNNSNNNINNDLGPKEHKVLIEADVPPPPPLQIKPSRARKQLAVRLAARRRAEVESLHQGGKNEQEGDGEGEETQDHLSSTSSSSSEEEDGRQGHGGNETNMGKRKRSYTTEAKRNLLDDDDEEGEDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZR0</accession>
    <name>A0A6A7BZR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chalcone isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_299544</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZR0"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="2">
        <location>
            <begin position="199"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="416" mass="46522" checksum="FD75B0388720773F" modified="2020-06-17" version="1">MTAPTRQTMRLLSPRLQTVRSSVSTSSCQWRLLSTRYSDPARHASAARSWASSLGVEAKESTSGPQNPYVNTINPWEEERAYYARRTRFALIGLTGCIVGIAVVCWRINVEAEKNQQRLREQQKHGSYQMEAPEDGNLKFQGKEVHVVGAGDGKRIVAQGPNGDELELVETGTSYVPHFPRTIELPCSPDQGVNGPQEGYTLIGLGIRTVFYFQVYVVGMYIRTEDISALQSKLIRIVNENASTLIPAEKEQLEKRLLDPVESRQIWMELLKTPGIKTAFRITPTRSTDFSHLRDGFVTSINARKAEARSEVQGQETEYDSEDFGQAIQKLKSIFTGRKAPKGSVLILNRDDNGALNVMYQPKWDKQERPVEYMGTVPDQRVSRLIWLGYLAGSKVSSPSARDGIVSGCSIETMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZZ9</accession>
    <name>A0A6A7BZZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_294700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZZ9"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="17386" checksum="46D248EDAA8A8712" modified="2020-06-17" version="1">MSDNTSTLQSVVDKASGMAQSALGSVTGSTADKNEGANKQHEGNLKDQASHAGTSIGGFSVGPTGVAKEDPKRQEGSWDQTIGSAKESIGGLVGADGLKGQGQQQRTEGQSKQASGELSDLGSGISDRAKGALGGAAAGFTGDRDKQSEYQSIHDHGKALQRGTEDALNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C091</accession>
    <name>A0A6A7C091_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="269" mass="31620" checksum="78B5262070193DE4" modified="2020-06-17" version="1">MSIDRNEALDTAQPNTLLGIAHPSGTMMPQPLPWCQPSIRHQHWHELHNNRGPPRDPFQTRVLLTIPRLQSHSIMPTYYYESSSPRTTIRIDVKVPMTPTRHTTTRYHSPNHHHQTPCKYGKCDAHYPAPPHRDPYVIPLPPIGRNATHARCDDEPLGYARSHQATKAEVEALDHRYGVHNYEYGDVQQSRYRANFRPGRYDPETDPFHQSGRKRPRVKEARFQTVVRNSYRYENDPCESSRYSHNHSEEKRYKSYDVKYSCESHYLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0D6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_257903</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="277" mass="30767" checksum="28F989A73EBC2985" modified="2020-06-17" version="1">MLYTHDSKDCISEWDIEKACIVRTLDPGYTSGSILSDGRFVPLRFLPVVDSLAANEDNQPQTQADSSASTSSTSLSENRQIWALDHRENWITVNGRKMAGSLDNSAENFISAFTEMVDRFEEIEQVFKAPRDSKTIDNTEAIFRKAKEDGRLVIKAMQEFRVKLSFANISEPANIAKPSFMTTRKEYKPRSITGGTMSRATSTSSTPQRRAVGFATGDGDDDLPRSTPGPPSTPGSITSRKPDQLLGDYWFSCGRTMTFSNEETGFTVLYFTGKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0L9_9PEZI</name>
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        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="506431at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29164" checksum="BF596BF37C65CB80" modified="2020-06-17" version="1">MSGLLRPRVIGSAAALATGLVGGNMVAHTIAPPAMPERGSHEDKVLMEDLRRRLDDNFKVNVLRGKCNNARGKLKGEDGSGWVEVTENLSGSNSYKTQLGGVKGLGLQRVFWNSTANKLVAVIWFGPGLTGWPGVVHGGMIATEMTGKMGLAAALARSGPTRWQEPQVPAPAEEEDPIELELQYVKPTLANRFYVVRVTAIADDASERDLEATLETLEAETCVKAKATFRPGSIRPIEGGSVDQREDKAKSFREWMWPSRQKASLELR</sequence>
</entry>
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    <name>A0A6A7C0M8_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Piedraiaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0M8"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="115" mass="12599" checksum="25446D2EBB0DDA68" modified="2020-06-17" version="1">MECKPVEKSNAPGIANDYQPDQVDKSFTAPSPSNEQQSDNPASAAKHKGAEHQATPPHAVESAVSKREDLIASTTELLPLYTHDQLLRSGISDHYDEEDVEAIMEAMEDFTGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0N5</accession>
    <name>A0A6A7C0N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0N5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="22139" checksum="99F1E49DF3245B66" modified="2020-06-17" version="1">MKTFLKVVRELAKILNRPKVPSLGRLKKYRKTIPNPQVIRRETKDGAPFYQISVLDIVCMQTCRNITEVIQYPDVVEQVATSSDGPASKSCSEMWHGTKWRWELRMQRPMEIIWIQGRPVSIWIGDVLRMCPSSSTEYALYYDLEIRFSQQTRENKKYVIGAISLILLEPVNGCIQGSLLSLFLPETVCWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q9</accession>
    <name>A0A6A7C0Q9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrial F1F0 ATP synthase subunit Atp14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_277037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Q9"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13478" checksum="BD532ABC73D771F5" modified="2020-06-17" version="1">MLGPLTLRTSRLVLARAGQTSARRAIATTPVRRADLVQELYLKELKNYKIPAVKPSDAEGQVQKFSMPKAPQSPEQPELASSLKEYEAQVPEVEGQSAEGEAAPVEQDWFEEPEDDEAPAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Z8</accession>
    <name>A0A6A7C0Z8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Lysine decarboxylase-like protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_281653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22562" checksum="6B90047AFDD361E4" modified="2020-06-17" version="1">MSSSPNDAKPVICAFSGSSPGNNASHMAAAKALAHTLHAHGYNLVYGGGTVGLMGELARTLVSLSGSESVHGIIPEALLKYEGKDIDKSTYGKTTVVKDMHTRKKLMADAVVQGGKGSGFVALSGGYGTLEELMEITTWQQLGIHQCPVVVLNIDGYWGPILEWVRNAVKEGFVAAQFKDIMLEAASSDQVVEDLKGYTYKGTGLALKWEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C165</accession>
    <name>A0A6A7C165_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_269940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C165"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="22012" checksum="3F97AD6327E3484D" modified="2020-06-17" version="1">MAVGQQRSTPAVVLAKELEKESDKVQTVEDTLTQREKAMKEFTVRDHLLGKELDRVEDKRTGLTAKAPKLAKNDYWRSNIWSDAAFERRCAHKVIRHYEEMQDHANEQVCRTMKAVEEAMAIWKRAAWARDLAARARKYTVEQRKHAVKEIEHTITLELNTIGAKRAMEEVKLAIDSIKCVNKASERALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C177</accession>
    <name>A0A6A7C177_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_216378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C177"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="482" mass="54279" checksum="0C89CA6955372741" modified="2020-06-17" version="1">MSSRNFAIWEDLPRELWLHILGFLNSKELVRCARVSKAFNEMCFDGQLWTCIDTTSYYRDISDEALAFIISSAGSFLRTLNLRGCLQVAQLRDVQRVAAAGKNIRNLTLEGTNIDPWAIEAFLTYNSGLRNLSVRGLSGVTSSTLQRLSVSCPLLQYLDVSWCHAVDKQGLAHVVGSCTRLKELRAAETVGWDDPEVAEKLFIHNQLETLCLTDCTSLTNQVLTILMQGLDSEVNGFASKVQAPPRKLRHLDLSGCKHISDLGLRSMIGNVPYMERLMISRCRVNDGTLGDLFRTTPLLSHVELQEMRGVNRYCLKSLATTCIRSLRYVNISSCRNVADEDVCTLLRKCDKLQRLKLDNTNITDKVLSETAGRSSMQELQLTVFDCGMVSWWGLREVLIANSRGKGMVKLRCCYKLQALVDEHTNMVLRGDLDGAGGAEHRGTYLVLAQEGNAARRRSWWRRRSLLPDSYVTVRRRAECLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1I5</accession>
    <name>A0A6A7C1I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2S7"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="238"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="436" mass="48222" checksum="F03CBDDF4B2B27DB" modified="2020-06-17" version="1">MVRQVDADVPQPGPAQLGSRAGPDEWLAEARQCHYLPENDMKRLCELVKECLMEESNVQPVRAPVTVCGDIHGQFYDLLELFDVAGGMPGDAEARAAARKERIATPTSPTRAGVINAADIEPPTQISDPKVRRKMKRRFQRDAAYLSPPAGEQAPSGAIDGDEDTRGRQMSRGGDAETGSDEESESEGGSGQSSRAMVDGKQNFVFLGDFVDRGHFSLETFTLLMCLKAKFPDKVTLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDYIALAAIIDGKVLCVHGGLSPEIRTLDQIRVVARAQEIPHEGAFCDLVWSDPEEVETWAVSPRGAGWLFGDRVSSEFNHVNDLQLIARAHQLVNEGYKYHFRSQDVVTVWSAPNYCYRCGNVASIMTIGEDLQPGFKIFSAVPDHRRAVPAGRTGRGEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C344</accession>
    <name>A0A6A7C344_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING/U-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_213830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C344"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="13086" checksum="C29D77F95E0BB844" modified="2020-06-17" version="1">MADVEMTDASAAKAKAPATKAEGEKPRFELKKWNAVALWSWDIIVDNCAICRNHIMDLCIECQAHQGSATCEECTIAWGICNHAFHFHCISRWLKTRQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C390</accession>
    <name>A0A6A7C390_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_256576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C390"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
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</entry>
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                <person name="Bloem J."/>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2862020.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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            <fullName evidence="8">ATPase synthesis protein 25</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
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        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="209" mass="23201" checksum="81B5F1A7B56DD80E" modified="2020-06-17" version="1">MPEFSLRPRRQELPSLPPHPPPILSPLLEQLSAQYGIDDISLLDLRTLDPPSALGDNLIMLIGTARSEKHVHAVADRLCRWLRSEPYKLSPSADGLIGQNELKIRLKRRAKRMRIRAMSAAATPEAELDDGTTTSWVCVNLGEVDGGVLPKQREQRMFVGFGSSHAGSNLVVQIFTVEKRAQVDLEKLWMGILERAREGGEADENGEGF</sequence>
</entry>
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    <accession>A0A6A7C4C3</accession>
    <name>A0A6A7C4C3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4C3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="132" mass="14852" checksum="8BB19ECA7100B8CC" modified="2020-06-17" version="1">MIAASLRLLPNQTQNSFPSLIFGIFLSPGSTQTPTRIWLLPCSVCPSSPAIRLQNPSLYYRVHLCTLTVSCPQVSRFFLMLIHLLWLSIDDAFLTPRNNFSKHRVLIPMIVDQVLILRFGSLHDPSSTLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4G3</accession>
    <name>A0A6A7C4G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4G3"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="340" mass="37253" checksum="B8E312683794C0A6" modified="2020-06-17" version="1">MLEILHHLTSLYHSFSHLSHAMDDAHQESNVQAYKVQETVDFLRSHLPERLARPRVAVVCGSGLGGLADVLDMEPEGQSWPYSSIPNFPVSSVSGHQGKLLFGTMGTQKVPVVLFVGRVHFYEGHDLAVITFATRICCAIGVKTLVLTNAAGGLDPSYSVGDIVLLNDHINLAGLAGFHPLRGPNDDELGPRFPPLSDAYDLSLRMLAHDVWNRLRSEKPSNRRLHEGVYAFAAGPTYETRAECRMLRTLGADVVGMSTVPEIIVARHGGMRVLAFSLVTNIANQEPTQRADDPKLKGLSPAELDTFLRQGRADHEEVLEAGRLAALDMQDLVLRLVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4H2</accession>
    <name>A0A6A7C4H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_243002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4H2"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="266"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="375" mass="42318" checksum="A6A1C4F4F2D3E24A" modified="2020-06-17" version="1">MSRFHPSITPEALLGRNDSKNPDTTCKGITTSGRPCRRALAVDSGRILKGGAGGVAALSSKGNADFYCWQHKDQARAQLPAQAPILPLKQRTSIDTLMERLNIEERSNAKPSNPPMVEEDPRQSPLSSRRKEQRKKKPSFWASLCCITEHSDDDYLEIVRHEHRVQQQRPGNGARPSNNQKILSLIPPNLSITTTSSILNELVKPFPANDEEGYIYIFWLTPQSQPAPGDETSRSLLSPAKGAGPRERRISDVLSEFSTSSTRGKPSHSIKLKIGRANNVTRRMNEWERQCGYTLNLVRWYPYYASTAGLQVGKVRHVKRVERLVHLELAEKRVLTTCDACGKEHREWFEVEASKRGVKEVDECVRRWVSWAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T2</accession>
    <name>A0A6A7C4T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="83" mass="8455" checksum="B3A1D62B28C09AE3" modified="2020-06-17" version="1">MSLPRALSARDRHAKALRNDLLSSLYLRIAAGLAFSGSSGILRPSRLVGDGLGVGEGTLAGTVALLLEVLGPLSDSRGDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="50" mass="5769" checksum="F4AD151D006747B4" modified="2020-06-17" version="1" fragment="single">IEWGEGCWIQASPLARMQGTCIASQRYLLHYQLHPRFLPHRGFPSGSCHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5B4</accession>
    <name>A0A6A7C5B4_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Cell cycle control protein cwf14</fullName>
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        <name evidence="4" type="ORF">K470DRAFT_269429</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861898.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="144" mass="16681" checksum="E170ADF55032D55C" modified="2020-06-17" version="1">MPKPKSKPPAGYEDIEDTLLEFQARMKDAEQSTDEGKRKHEAQWPIFQISHQRSRYIYELYYEKEAISKELYDWLLKNNYADALLIAKWKKQGYEKLCCLRCIQPKETSFNSTCICRVPRAQLGEGQGDIECVNCGCRGCASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5L2</accession>
    <name>A0A6A7C5L2_9PEZI</name>
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    </protein>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
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        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="717" mass="78481" checksum="1CC88CA573D5281C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Z9</accession>
    <name>A0A6A7C5Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin nucleotide-binding domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_199091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Z9"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="7">
        <location>
            <begin position="107"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25278" checksum="13D8B33F78FE95B9" modified="2020-06-17" version="1" fragment="single">MHEIITIQIGREANYVGTHYWNTQSSYTTPLLDHNISFQPSLTSKIETPFPRTLIYDFKSSLGSFIHDQDPIEPETPAEEGLTTIQTTPSTPSHPYQVALSTTFDPPTPLPETVRYWSDYNRTFFNRRSIHPLSDSPSTPGFELFNNLDTTDNGIVDTHLRPLLEECDHLQGLQFLTSTTTPWNDFTTSYLEQTHDEVGKIPLWVWGCGSDSSSRRVVQQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6E0</accession>
    <name>A0A6A7C6E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_291577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6E0"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47540" checksum="28260FF621C8C53B" modified="2020-06-17" version="1">MNSMLVEDFNALPPTFGLDPWVPNEWIFGFRTTLLAPDQEYVFAMHTTSDRCLLAGLRKIFGQDTEVKRAINAVELLFRAFVDQSEDPGLQWLRPDYPCAPTRWYCGNESLRRPMMEVLNYLNIREDLKIIHETNPIVDMMFNRALSTWHFAPIFAYGLGITGGKNTSNCPYCVAGLRPRRGVIRMRCLHSADIRFCTLDCQAATRHRHMYECTNMGPISDALRTFVRKSPVSDERHELARRANIMLPSELGQFEGFSKPIRRLLQSGLFTNYNLQILFGLDWPQALSRLAADIRYSTLLGPAPGSMRQLLNHQLDVEPLTKRNMRPRATRQEREGLSYARDLRHTLGLHLRFSKISQMKFVDFLEFFEMWGMRLDNDMRLTYVLILQCMDPNVYRLQEWERAMISIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6G5</accession>
    <name>A0A6A7C6G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_201984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6G5"/>
    <dbReference type="OrthoDB" id="3644463at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="86" mass="9923" checksum="99438F9910383BB8" modified="2020-06-17" version="1" fragment="single">IRRLVVTGHDTTDNMIMLFGRSWREAIGPIWSDVRLRALLKAPAFSVEALQQAIMDSGTPRDAPRPPTKQERSRMRFVLETEDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Q0</accession>
    <name>A0A6A7C6Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Q0"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="442" mass="47709" checksum="9A4A0ACDC6E7CCD3" modified="2020-06-17" version="1">MADAIEAIAEKAAALTIESTAEPKLTPAELKKQKKAEKQARRAADKEQTGAKAESAPAEQTPRKASIPAEKKPSKPPEKPKPEKAPPKQAPKQTEAEKPAPKSQPCERSQVEIFSHLFAQPRRSGLENTHKDVHPAVQQLGLQMSSYEVCGSSARCEGMLKAFKRLVQAYETPAGQSLPRNLTHSLGPQIEFLKSCRPISESMGNAIRHLKKLVVNVDPSMEEHAAKEYICEEIDRFIHERIYVTDAAISAQAAGQIKDGMTVLIYAKSAVVTQTLLKAHESGRRFHVIVIDSEPLHEGKASACKLTAAGVEVSCFTYASAGSVMSKVDLVLFGAHSMLGNGALMSRIGTAAIAMHAHGKNVPVIVCCESVKFSGKVALDSVAYNEAADPESFGDVKEDGCQVLNLMYDVTPEEFVTMVTCELGNVPPRAVPAMHRLANEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Y7</accession>
    <name>A0A6A7C6Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_210856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Y7"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="40006" checksum="A516A50C0F6EBEAE" modified="2020-06-17" version="1">MPECGSGNDYNGNLPLRISAIFVIFVGSFLGAWFPIYAGRHRGTHVPAWAFFAAKYFGSGVILATAFIHLLAPANEALSDECLEGPITEYPWAEGISMMVITVMFFVELMTMRFAKFGHDHGHDAEPKGKPEPEDADSHSLRPVKALRQSLRFSLTPNIEGAGPVCGGPHVPGDNHLSHSWGHVDRQSYVSSRVDRHSGKYDPDSYAAQMTALAILEFGVVFHSVLIGLTLAVAGDEFKILYAVLTFHQTFEGLALGTRLAEVEWPVHRRWLPYVLGSVYALATPGAIAIGLGIRKHLHPGSSSSLIASGVLDSISSGILIYTGLIELMAHEFMFSEYMQQASIQQVLSAFGTMCMGAALMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C713</accession>
    <name>A0A6A7C713_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NAD+ kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_274835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C713"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="442" mass="49209" checksum="452BF7DBA943A70F" modified="2020-06-17" version="1">MDQGHTEAFFEHRKGERRPASLASDQDSDLRTSCFVHSLLNRGAVYPKNDEQSEHSGSANGTITSRELSKAELTDMAYGIRELAKRLSNLRFQLKVRNVFLLTKLHDRHLIVKTREICEWLLEQRQEDGTQYTVWVQDILEHNPSFDAKNILTKCPSYKARLHYWAADACRESPHAFDICIALGGDGTVLFASWLFQRVAPPVMAFALGSLGFLTKFDFNQYQLSLPKSFTEGVTISLRLRLEATIMRAQLQHGDKGRDLVDELVGRSCGDITTHKPDQAHTILNEIVVDRGPNPTMSSIEVFGGGDHLTTVQADGVCVATPTGSTAYNLAAGGSLCHPENPVILVTAIAPHTLSFRPIILPDTMVLRVGVPYDARSSCWASFDGKERTELKPGDYCTISASRYPFPTILPLAGNSQDWVDSISRTLSWNARQRQKQFDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C719</accession>
    <name>A0A6A7C719_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1604-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_268805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C719"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
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</entry>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="316" mass="35450" checksum="310EB9AF38B0918B" modified="2020-06-17" version="1">MPIPRLPIGSIHRLSTSPFPHSSITITPAQLFTALRSPKTKESPRILPISAGWFMPNDPFHRTGHNSFLTQHIPGSVFFDLDAISDETSPYTHMLPPPTKFADAMSKLGVKRDDTLVVYDTVELGLFSAPRVAWTFRHFGHKSVFVLDNFKLWVEQGYGVEEGEMKVRERSEYPVPGVDERVVGFEEMKELVGGEDVTIVDARPEGRWSGRDPEPREGLPSGHMPGSVNIPFGEVLEPERRTLRGREELRNYFEKKGVVEGKPVVSTCGSGVTATLVDLALREAGYKDTRVYDGSWTEWAQRVDGDDGRWITKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
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    </reference>
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            <end position="32"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="148" mass="16386" checksum="5AFDEB5AF23E0464" modified="2020-06-17" version="1">MAAAIDRLGDTINVSLTLFLQACPAIMFFPLAEKYMALMGWTVVQPDNGGPVQARRVQNIASSVLLAQSRNRGATINELILHLIREGMVNTVAGVANPKQSDDEEKTRFASYADVKDQKQSLDVTLLRESIEQRAELRKLKGRGKFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="596" mass="65608" checksum="34787FEC0BB8F9D9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C899</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD26</fullName>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
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        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="337"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="666"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863796.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118607" checksum="7A378B6E2CA40C4A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8E5</accession>
    <name>A0A6A7C8E5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255364</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="392"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863245.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="486" mass="53188" checksum="4076093A6C310BEA" modified="2020-06-17" version="1">MAKRAAETEPSRPLKAGDRQAEDVADDQQFEDEFEDEYESEDEIFEAGVDGRPDAEREAEEKASGAMEVDRETFIPGRHRLDEGQTLEPDPTAYVMRHGLGTTWPCLSFDIVKDSLGEGRRSFPATVYAVAGTQAAAGRERENQLMVMKLSGLGPSEDAENTNSDDEDDDVEMSDPVLECKGISLTSTTNRIRAHQSQASSSPTTVTAAMQESGEILIHNVTAHLQSFDKPGFQIPAAASKPLYTVRAHKKNEGYALDWSPIQGAKKLLTGDSVGSMYITQGTDGGGFVTDTTPYKGHTGSVEEVQWSPNEQNVFASASSDGTVKIWDARSKNRTHAVSVNVSTSDANVLGWSHHTHYLLASGHDDGTWSVWDLRQWKSPSTAATSKPIAHFSFHKEQITSLEWHPTDNSIISVCAGDSTLSLWDLAVEVDDEESRYTADVKDVPPTLLFLHYMPNVKESHWHPQIPGAVMATGGNGFEVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8L6</accession>
    <name>A0A6A7C8L6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_225962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
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        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="506" mass="55271" checksum="58E29FFAECDA01C8" modified="2020-06-17" version="1">MYLPLGIGAAAAALYFGLQRTTPGLTSLKPQTTAAETPEFGRKALVVDRDQFLVADVPGDQPINKDTDFSRRKLLEMLTPEQASAKLRTNQESYLVSRGAGVVRYDVVQIPSNDPIEDDHVEKIVEMPGQSDWMFWGVFDGHSGWTTSAKLRQALVSYVARELNNTYQAVATPSAEAVDAAIKQGFLKLDYEITHEAAQKVMDAQSKVVAAQMLAPALSGSCALLSFYDSRSKELRVACAGDSRAVLGRRTASGKWTATPLSVDLTGGTPSEDARLRAEHPGEPYVTHNGRILGGLEPSRAFGDAMYKWSRGVQEKLRSKYFGRTPPPHLRTPPYVTAEPVITTTKMDPSKNDFVVMATDGLWEMLSNDEVVGLVGQWLETQGMVSTPSSWVPSWLRGKSTSLPLEPSNTGEQGGQRIPIRQRQWNVPSDTGRFVVQDANAATHLVRNALGGRDGEMLSALLTLPSPQSRRWRDDLTVQVIFFGEGEANGSVEINHEASATTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C920</accession>
    <name>A0A6A7C920_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C920"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="256" mass="28133" checksum="3A1EC38B5402C902" modified="2020-06-17" version="1">MGMHEGQRVLDVGCGVGGPAREIAKFTGASIVGLNNNDYQIQRATAYTQREGLADRVSFVKGDFMQMSFPDNSFDAVYAIEATVHAPSLEGVYSEIFRVLKPGGVFGVYEWLMTAKYDNSNPHHREIRLGIEQGDGISNMERVDVALKAMEAAGFILESHEDLADRPDPLPWYYPLSGNLKYMQSIWDLPTLVRMTHVGRGLLERVVGVLETVGLAPKGTRKTANSLAVAADCLVAGGQEKLFTPMYLMVGRKPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I1</accession>
    <name>A0A6A7C9I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_205342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I1"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19353" checksum="5B90CDEF4F7DC253" modified="2020-06-17" version="1" fragment="single">RVAVTQSYFWPDLQLNLWTLIMLATGGVLIGIYSTFLVQQQHLGLGVPWIMPFGITVGALTVLYIIILLALISQGRLLPGVVILGAFILFVLYLTGLIETAIQLFGPGRVLDACNKYVENQQAKGLSINTLAWLEQDSICSEWEAVFAFWIIGTLFLLWMLFMAAMVARSSRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA73</accession>
    <name>A0A6A7CA73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA73"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="69" mass="7621" checksum="9DC1080D3AEF1B90" modified="2020-06-17" version="1">MTCDGCKNAVERNVNKIVGIDKVTADVDTNTVTVLAREGEVDFRYVLEQIKKTGKKVNSAKLNDEPQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAQ1</accession>
    <name>A0A6A7CAQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_240484</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAQ1"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="403"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2863688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="510" mass="56192" checksum="48DB275CF9F75178" modified="2020-06-17" version="1">MEGVPIVTSLSQIYPSPSIPFQTSRWKNLINQFIQTHGCAPTCISRSPGRVNLIGEHIDYCLYSVLPMATEADILIAVSTLSTPPPNPHKVLISSTQPAKFPPRNLPASDLKFIDSSSLEWTNYFKAGLRGATQLLPSQSDPTLPLHSILVDGNVPSGGGLSSSAAFVCASALAVLYANNITYIPKKSLVEAAVTAEREVGVNSGGMDQAASVFPIQDEAVYVSFVPSLKVENIRFPPENDFVFLIAQTYIQADKYDSAPECYNLRVVEVTLAAIVLAKLSGLEEGLRRDASPLGVSLRGFHDAYFAQDEEVKKNVFSSQLNQLVELVRELLTQEEAGYSREEISSILGLTSKELEERYMTKFPIRAERFMLRQRALHVFQEAGRVLRFYNFLSHPERVQNLPAALGDLMNETQTSCRDLYQNSCPELDKLCALAREAGAYGSRLTGAGWGGCSVHLVPKDKIDAVKRRWKEEYYLPLFPYITEEKLNEAIVISVPGSGSCVYTGDLIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCG1</accession>
    <name>A0A6A7CCG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_279751</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCG1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="95"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="470" mass="53023" checksum="74A019C2EFE25082" modified="2020-06-17" version="1">MSLGTDGPDLPPVPVPSSCWNPTKTSNIQKPHITETPMTRKNWYKHVNWLNVTFIIGIPLIGFISAFWVPLRTATALWAVAYYFTTGLGITAGYHRLWAHTSYSATLPLQIFLAAVGGGAVEGSIRWWARDHRAHHRYTDTEKDPYSVRKGLLYSHLGWMVMKQNPKRIGRTDISDLNDDPVVVWQHKHYKLVMAVMGLGVPCVVAGLGWGDWYGGLAYAGILRLCFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWVIWFWKQIGLAYDLKQFRANEIEKGRLQQMQKKLDQKRAKLDWGTPLDQLPVIEWDDYVSQCKDGRGLVAICGVVHDVTDFINDHPGGKALIRSGIGKDATAMFNGGVYNHSNAAHNLLSTMRVGVIRGGMEVEIWKRSHQENKDTMIVKDENGNRIIRAGAQVTKVYQPPTSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPY9</accession>
    <name>A0A6A7BPY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPY9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="7779" checksum="326A7EBA6609C0A3" modified="2020-06-17" version="1">MSYSSSLSGLSGDWAEMCASPDWSRRQVPGHVTSPFVTTSDSWSRDVTTPDSCSRDGTPTRAAIIGRMGGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQZ6</accession>
    <name>A0A6A7BQZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_283715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MU006034">
        <property type="protein sequence ID" value="KAF2857634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQZ6"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="156"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="42709" checksum="9470A213ADA8B226" modified="2020-06-17" version="1">MESFNGMLLAVVGISALTFIALFGQLPALTKSPIGWMYRMLCIHVPGGMKAADRRISGGAVAARLSRLNEYLFYEKNPIVLIVFLFVLTGSSLLFLCHGPSLLPWHLLLPVPILLGLPYYFTYLCVTDRKHMIVPKNHEARIKDYPFDHLLYRPGVVCSTCNLIKPARSKHCSFCRGCVAKCDHHCPWINNCVGRGNHRYFLALLLSLTTLQAYGAYLSWYILKPYYNPLQGVSWLSAEYWDDLGWNFVELMDQGGLSIAGVGMLAAFTAPLPLALLLYHLYLIWAGMTTNESQKWADWRDDMSDGCVWKSDRETLKGRSGYDAPCKSGAEGDQVIIRTCDGQPPKGEEALWKQIWSLKDVDNLYDLGGWNNLLATLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRL9</accession>
    <name>A0A6A7BRL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_223172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="MU006038">
        <property type="protein sequence ID" value="KAF2857547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRL9"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="27747" checksum="1F52F72DB25AE721" modified="2020-06-17" version="1">MDVPNVQPGGSLLVAWQVRDKRVVVVGGGEVAAGRILNLLNADAKVTVICPRQGLNKEVAYRVTQKQVNHVDRVFEPSDLDDTAIVMVLTAIDDPEASTRIWKLCKEKRIPVNVADVPPECDFYFGSVHRDGPLQIMVSTNGNGPKMAAMVRKSLAQNLPPNLGDAITKVGALRKKLRMLAPGNDQGPKRMTWMSKVCTNWSLEDLCDMNEDDMDALLQFYEPDQTPSLNKLRHGEDESIFDGSFGWSCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS50</accession>
    <name>A0A6A7BS50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS50"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="10876" checksum="AC682C273C361362" modified="2020-06-17" version="1">MPRSDNLPSGQSREPKIISSTTNSTYKSSTNTLSAPNGGDRGNSKNGKKFYNEPSSTTNSTYKSSTNTLSAPNGGDRGNSKNGKKFNNEPSTKDAQYGGYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSF4</accession>
    <name>A0A6A7BSF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IIA, alpha/beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_296638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSF4"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="400" mass="44238" checksum="D82722163F1F9FE4" modified="2020-06-17" version="1">MSRMLVGDVYAKIIEAVVEGSKSDFEEHGIRSSTLEDLQKGWQIRLTQRGVAHMPWDPKPAPVPVQQTPLPLSTTHGMPSYGYPPQQGGVRVKGEPGSEHGYLSNGYAADSSVLQGNEYRARQLMQDYGQTAVNAQRAGLALPGQRPQAVHQAGQQTQHAHHPHSQTAHQLHVTQQTLYAQQRRQMMMQQQQAAAQTHQAPSQAQAQSQSRVKVEHQVQPRIKLENGSSAYGQTDGAHEGLDEWRNLVAQRRAAHAANGEQADGAIRDMIMQSRSDMESGLMLPLAGASRCRLSLRGAVPQINGTTFISQLDGVPEDEQKATAGVKVSDDEDSSAINSDLDDEALDRVNEDEDDMCDTILCTYDKVQRVKNKWKCTLKDGVMNVDNREYVFHKATGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSM7</accession>
    <name>A0A6A7BSM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSM7"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28668" checksum="5209E130DCC97D4B" modified="2020-06-17" version="1">MPQLTHFLALPLVNPSSKQQLIQSLAHLHSTISSHREADTLTKALRPLHTLHFTLAVMSLSQVQLSSAVALLQELKPSELLKRNNLKIELVGMKPLQSRTTTSVLYAYPFEDGEVRSFAEDVLKIFREKGFVDPVGQEEAKEERRKLEGGGESEPDGKAGGGSAVGAKPQRKSKRKSKDLLLHATLLNTIYAKSNRGKGRKGPLKFDATPFVEKFGDQVWAKDVLLDKLVICEMGAKEDESGVVRYKEVGALQLFPDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF7</accession>
    <name>A0A6A7BTF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_278533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF7"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="392"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="452" mass="51045" checksum="3F7830CE401F0303" modified="2020-06-17" version="1">MSWKGFQKGVVRAPQQIKQRFSVGELTKDAIYIDAERRFADLEKETKKLHDESQKYFNAINSMLDHQIEFAKACAEIYKPISGRASDPDSYVIDGNPEGIRACEEYEVIVNELKASLQPELEMIESRVVKPADELMDIIKVVRKATAKRDNKQLDYDRHRATLKKLQDKKDKSLKDEKALYKAENDVELATQEYEYYNNMLKEELPQLFRLEKEFILPLFQSFYYMQLNVFYTLHEKMQNIDIGYFNLQLGIEEAFEAKRGDVQAQIEALGMTRFKTTGGPRRPLSKYNSGRLAIENGRPGSSGRLAIENGRPSSSGRLAIENSDTGHRRATHSSYDQPPPPYSPHAGNLSAGSPDVNRSVSTGSNWTSAARAKGKPAPPPPKPKPAALSKPPVETCEALFDYDAQAADDLSFKQGDVITIVQRSDNTNEWWKGKLNGAEGVFPANYVRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTL2</accession>
    <name>A0A6A7BTL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259694</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTL2"/>
    <dbReference type="Proteomes" id="UP000799421">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="71" mass="7938" checksum="91057BA180841A5C" modified="2020-06-17" version="1">MNLSRSSTPLPAFLSTNAPSKHSTNLFAPPTAKSLPRNQQSRGEDVRFPLSNDRHLNRQTHPELAPQLIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BTT0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_220918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
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        <property type="entry name" value="PRK03996.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <end position="27"/>
        </location>
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            <end position="245"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000551"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00388"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="254" mass="27867" checksum="BD36F5B38577368F" modified="2020-06-17" version="1">MASGYDRALSVFSPDGHLFQVEYALEAVKRGTCAVAVKGESVVVLGCEKRSAMKLQDTRITPSKISMVDSHVCLAFAGLNADARILVDYARVEAQSHRLTVEDPVTIEYLTKYVAGVQQQYTQSGGVRPFGISTLIVGFDPGRSEPRLYQTEPSGTYSAWKANAIGRSSKTVREFLERNHRDGMDREATIELTIKSLLEVVQTGAKNIEIAVMSPGGKPVEMLPPDAIEQMVEKINREKDAEPTTRRGNQTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTT3</accession>
    <name>A0A6A7BTT3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259787</name>
    </gene>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="887" mass="98694" checksum="AC31F828BEF9E394" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BU52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU52"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="22558" checksum="11CDD147F449C6D9" modified="2020-06-17" version="1">MTSGHRCWCTYSHKPWRCTEKGLAVMQSNEMRAKSSSSTGRWCLGLYPSQIPICDQAGSSSRCSFPGPMSISPSDWRPPTALGIRFYHIRLSTFGLLLTSVHHPAARPGLIVRTPRHLSAREFGVPHPCRKEQDSKPLPMPTLLTILLGSDSVPMVTSSPPTAYFDVSPRNFRWDLEVTSTVHTFRQPILSCGPSLQHSWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUQ4</accession>
    <name>A0A6A7BUQ4_9PEZI</name>
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            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_265667</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006000">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="632" mass="71364" checksum="8940392735D61EAD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUX4</accession>
    <name>A0A6A7BUX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_278437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUX4"/>
    <dbReference type="OrthoDB" id="2247093at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP"/>
    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="28725" checksum="C24137BE875088CD" modified="2020-06-17" version="1">MPPSPAQSPCSPRMPSFALQPPQATINVQQRPFLGSPRQLCNYPRKHQQPHSPPQQQPYSSPRKQHSLPLYSAPQQYHYQYSNQFSHPTPPSEPSRSKHSRRSASPTNSRHSNQSYNSHSLPNAYKMMTFDLAAGPVRRTPASRVADEKRRRNAGASARFRQRRKEREREAYQTIARLQQTLRKLIEELEWYQRERGYLEAILRSLEDGKRFFPRPKSPRSFRESWNFDERLLWNPYEAEQRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUZ3</accession>
    <name>A0A6A7BUZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5296at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11955" checksum="AC6260586BB8E4FA" modified="2020-06-17" version="1">MSARVGSISDNRIGGWYSYRSSKAALNQITKTFDLHLKTVAGDRAVAVAMHPGTVKTGLSEGFWGNVAEDKLFEPEFAAEKLMNVINRLKVEQRGRCWDWKGEEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVR0</accession>
    <name>A0A6A7BVR0_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_219285</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="341259at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="94" mass="10346" checksum="9D91B98D7DCC443A" modified="2020-06-17" version="1">MLCEEGSSKRTVLMHAVERNEEDIIDLLFKNAPRVNVNICDDKGLTALHIAAGKGNSGIARLLIKHSANMEAEDKFRETPIFKAVEAGKLELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW47</accession>
    <name>A0A6A7BW47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PIG-U-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_300224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW47"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="372" mass="41650" checksum="6B40481D061CC27F" modified="2020-06-17" version="1">MWTYPLISSNCLRPVATESSLLTPNPPLFLALFSLLSPWTSLLLYAALDLEIAHCLCNIAKSGAAYSSRLYTSPRKGRSWSPISVAAVYRFKPLTLMTCLARPTAVFTTPFTLYAVSSACEARPYRAAFSLAVASYISLHSLLLVHPVGLLCYDRAKGRPDAVVFGAKLARLVTETIMFLLLLSRWLLPSWTFLESVHLTPLTMPDLTSNPGLWWCLFIEMFDAFRNFFLGVFWLHMLSYSVPLTIRLKKQPLAAVILMLGVISVIQPYANIADTGAWLCSLTLLGHVFELSSAHRYTFPALATLLYCMFLGPAFHHLWVYAGSGNANFFYAINLVWSLDLLVLLAGAIYAVMRDEWEQQRPECKGNESRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG1</accession>
    <name>A0A6A7BWG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_100567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWG1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18599" checksum="09DC2B0081704C58" modified="2020-06-17" version="1">MKPVYDQFKLALQELQAIQAQGESRRIQCTNRFRTQWDLPGRHEIMGILEESARNNQEAALSMDSIDRHWHLDADMMPQSEVARERRAKNDPHALPGWRRGPRGVAPMPTEHSAGTSTRREFSLDEEGAELLAQVTRDAATTGSRVAPARPDSILERGYWWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG7</accession>
    <name>A0A6A7BWG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_295574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF56">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="58126" checksum="A06F64D9E3355443" modified="2020-06-17" version="1">MAMNIIERLRGSLTRNKSDADKLAAPVRRPRRTRSTDRYRPNYEPYATFQPKVQALTESIGNFESILLEHRKGGTFNRVVVAHLRARGQKIEGVYRISRADEKPQLDAREKILGHDIQDQVTVLQLLARRSIPAPRLLAFDASRGNPLNCRYILTSLSSGCRLHDIYDSMTLPEKLNVVDGIVEFLLIMELVTFPLTGIITSSHEPGMAIKGSLFLDIGLPKFERYIQEFWVPGNVDMEDSLGDYLPSMLKARFEGEDRDTGSRLLANVCKISNEMKQHGIFNLRHKDNVSTSRSILHQWDLFPRNIMVAKSGPQQEWKIDMVIDWDHVQAVPAVLTRRPPFWLWDREDIYRMPNVRSDFADAGNERFSPDDQQIRNHFEERLILGLGDIYGNYTKEDYHDEAYERGRWIRRLAHLAFDNLSESYIPVIAHFENDWETFMRGHPVDPPKFPLFGKPGPFRMTVTEAWRKEMFGNPGRKPGARDYLSVLWKRTLKHGLRLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWH3</accession>
    <name>A0A6A7BWH3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWH3"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025372696" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="242" mass="27079" checksum="B968A68390777B1E" modified="2020-06-17" version="1">MSSIVKLLWAVSTLCEAVPLGQSLLSTPSSSDGRPSIYNSAVMARRIMHLSSIGTLVTTFPPASDEASVEETRPDSVAGSPIGLMEYFADCEPESGNPTLLAINLASPYKNYASGSKISLHIRWWPIQTKHYPIAEESDDIPTPHTPAALPRFSLHGRLEDIPQDEVRDKSIDKCFLKSHPDSQLWQPGNDIHTSKYVRFVVEQVYWFGGFGDRARILWLPMDVWRNVTMQEIEKVRLPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWJ1</accession>
    <name>A0A6A7BWJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_277683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWJ1"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15783" checksum="D09E80ED0EBC9305" modified="2020-06-17" version="1">MTWYDYLSDIGSALLPSVSLAEAPAKENKEDKEDEGDDEKADEGGDDKEEEVEEEEEEEEEEEEEEPVDPMPKLQEDCMKTKQCAPLKHHYDECALRVQKQEEANDGKADEDCVEEFFHIMHCANQCAAPKLFRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWT5</accession>
    <name>A0A6A7BWT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_90903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="114"/>
        </location>
    </feature>
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            <end position="149"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2860076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="128" mass="14007" checksum="7E03A3EA839CDBA0" modified="2020-06-17" version="1">MFQSLVVTLAFLGQSFPRQKSLAAPTANSNVVMTRPQNITSASIPYRGEAASTSLHAWTPKLWFSTWRSTAARPRRIPPFVGRLPLRCLPTFTTSCFCAVQLLSAMRPYIALPARNLVCGARAAIANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXK7_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2859970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15046" checksum="3373AFC4D1E128D1" modified="2020-06-17" version="1">MSQVSDSRYTMAEVANAARRFDPKMLPQGYGVYHASDLSIEGVYATSEGALIALENSEMLGYYVLSEAAYSGERGPNRTNNPEGATIYYDYKCHMSRQPFWHWMLDNYTEMSLQAPCEDCEQQASGRMVAVVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXN5</accession>
    <name>A0A6A7BXN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAPS-domain-containing protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
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        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
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    </dbReference>
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    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
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        </location>
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        <location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="826" mass="92150" checksum="FED9551E097A095E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXX1</accession>
    <name>A0A6A7BXX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_77256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXX1"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="15553" checksum="BC3E30DA614969A6" modified="2020-06-17" version="1">MLAPRMLSREEEAQMGMEKEVRKEDQGRINRFSRLHGHQKSLEDDLKAKEEREETEEMSNELELADEDEKVAYKIGDSFFMLPVGRVQDLLSESAERIAAETKTLEAKLTTLREEMSELKSALYGRFGQSINLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYD5</accession>
    <name>A0A6A7BYD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_77962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYD5"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="337" mass="37787" checksum="1CCD85EDF11C621A" modified="2020-06-17" version="1">MEHSDNPPDQPTSTENRSVEHVRPSVESPDQGSASSTSGRILLQHHPASFLETVGGATQPAHGLQQHEYDGLQYAQSRFPQAQAQYPVYGPSMSYGSSQHYEHIPQWREGAGAAFTPSAYYIANHRNPVSASNLSAHSLAAQYQPGSLQPTDPSIAHYAFANAPVDHSHAVHYQYLDQYQLENQAVGRDFGEYQARIGTIFTLVKEGNLRDAKDLLLQISQYLLGNVEQFGLTNDDETLRDERIKLWDEFNSCWLSTMLRQYELVEKLALTGRRPQESQSMMTARELEQLSLELVHLCDAVERFGLVDYQMGVAEDEIMDLVIRILDLLEPAQQGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYP3</accession>
    <name>A0A6A7BYP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_271251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYP3"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="590"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BZI5"/>
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        <property type="reaction ID" value="UER00930"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2860671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="364" mass="40042" checksum="D7D3E595399F6E1E" modified="2020-06-17" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNRPMILHQVEALAAAGVTDIVLAVNYRPEVMTEALKKYEKEYNVNIEFSVETEPLGTAGPLKLAEKILAKDDAPFFVLNSDIICDYPFKELAAFHREHGNEGTIVVTKVEEPSKYGVVVHKPQHPSLIERFVEKPIEFVGNRINAGLYILNPSVLERIEMRPTSIEQETFPSMVKDGQLHSFDLEGFWMDVGQPKDFLTGTCLYLSSLTKKKSPLLASTSDPHIYGGNVMIDPSAKIGENCKIGPNVTIGPNVVVGDGVRLQRCVLLGGSKVKEHAWIKSAIVGWNSTVGRWARLENVTVLGEDVTIGDEIYCNGASVLPHKSIKQNVDSPSIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP0</accession>
    <name>A0A6A7BZP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding G protein effector of mating response pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_216820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="400"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="720"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="787"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="874"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="951"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1288" mass="141959" checksum="37FC2CE0D60BEC75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C016</accession>
    <name>A0A6A7C016_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_192966</name>
        <name evidence="7" type="ORF">K470DRAFT_197040</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="488" mass="55550" checksum="BE448AABEED38999" modified="2020-06-17" version="1">MDSQGESFDVIIVGAGISGINFAYRLQERLPGASYCILEGRHEIGGTWSLFKYPGIRSDSDLYTFGFPWRPWEEQISIAEGPKIIKYVKESARMYGIDHKIKFNHRVDKADFSTENKEWQFECTVSGEEKKTVRGKFLMICSGYYDYENPLQPVIPGLDNFQGKVIHPQSWPQEFDYSGKNIVIIGSGATAVTLLPSLAKKAKHVTILQRSPSYIFSQPQEDKLEKLIRALTWWNKGLQRRLVRFKWLLVQYIFSRACLHFPNFMRNTLGKLTKKQLPPAISPDPHFKPNYNPWEQRLCFCPDGDFYAALRNGSASIETDTISTVTPNSIKLTSGQELHPDVIVTATGLRMCFGGGINLSVDGEAFNVPEKYVWSGVMLEDLPNAAYVFGYVDASWTLGADATAQLITRMMKMMRERGTQIIVPRRTEREKSEMKEVPLVRLQSTYVAKAKSIMPKAGATGQWRPRSYFFHDILKAWYGDVESGIEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0V8</accession>
    <name>A0A6A7C0V8_9PEZI</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860639.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42772" checksum="F3B2F48AA0A07E61" modified="2020-06-17" version="1">MGGKSNRFDFTNRANSGVNLGNSIGSALVKEAEKLQRTAEKAERRGRKESTGSTLSFDPKDHGHAIDLQAPGKELGIDGVAAMSAGLGAALSKCTASTWLALESLSLPGNGLTAAAMPHLASMAQLSCRDLRILNLSNNQISITSDQDAAQWESLLIALSRCSRLCRLDLSRNEVGSRALEIFSRVYHAASPGCTLRSTASITLQDVGLGDAGALWLSYMLESHYSSDEESGFDWSANDKSLGKDGILLLQRTASKEISDHGIDSIRKRVQRHIIELDGVGSVELWAAALKLVNLARAMYILCECRESRTKKHKSGAQNGFRVQTRSGSDPALLTSLIAPHVARVHLLSEGQKTQAIRWGLCRASIQTALEWRKRDEASEIWLLLDKIECLSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0V9</accession>
    <name>A0A6A7C0V9_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0V9"/>
    <dbReference type="OrthoDB" id="5398685at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="71" mass="7679" checksum="9EDCD805F4D99C01" modified="2020-06-17" version="1">MAPEEPIATANGVEEADLAKAFQELAKGERTATALEQQLSTMEAKIEELLAQAEKGHQEAEQNKNIGESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C100</accession>
    <name>A0A6A7C100_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3684"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1382"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1646" mass="183158" checksum="4F90BA73C75793C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C130</accession>
    <name>A0A6A7C130_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_216274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
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        <property type="protein sequence ID" value="KAF2860937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C130"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="198"/>
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        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="495" mass="56398" checksum="4E4AC4DBD0273C7A" modified="2020-06-17" version="1">MLRVAFIYLVLVLVRLYFALAPSYIHPDEHFQGPEVIVGQFLGWPSFKTWEFTSEHPIRSIFPLWIVYGPPLVIFKLIAKGIGHSPSPTAVFYTLRTYMFLLSFVLEDWALHELLPVKRERVVALLLVASSYVTWTYQVHTFSNSIETLIVLWCLVLLRRLIDNTQKTQTKHCATLAALCVLGIFNRITFPAFLLSAGLETALLFFSKPWRLYVALFTGVLCTLVAIELDTAFYTNHRLRLRDKLRGAVFTPYNNLLYNMDPSNLAHHGLHPLWQHFTVNLIQLLGPAVPLIALSSRKDMLFRSGIGGIVLLSCFRHQEPRFLLPAVPLLLASIKLPTSKVRVFVAAWAVFNTLASIIFGIFHQGGVVPAQSWISKQANVTEAIWWKTYSPPRWLLGEENLKIITKDLMGSSNSMEKIYSELPCQTNDTKTLLIIPSSRESVVRETFSNVSLKPEWHFSRHIGLDDLDFEQGVWTGLRQIIDDRGLTVLHLSRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1C0</accession>
    <name>A0A6A7C1C0_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1C0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14703" checksum="639CC14F2541353D" modified="2020-06-17" version="1">MQRCTIPYLKFLYLYRFSRYTFCSPHSPDRSFARIPSSLSVLYVGEYPTPYSALRDLLAQLPTLNYLEVCFEAGDAIKFMEQLIRHDTLPQMVVTSKTHRALFSQFVSQPTWVSVEAFRKIHSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1D2</accession>
    <name>A0A6A7C1D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
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            <begin position="57"/>
            <end position="83"/>
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        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="11454" checksum="37C257B67D7337A4" modified="2020-06-17" version="1">MRGFISEVFDLVGHTAEKETEQAARKATRKAVRRFAWKAPVGPSAAVRVMKMTAATIVTATIATIAMIAMTTTTVTVIATVILKVTVTAVAAMPILDTAAIEIFVYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1V3</accession>
    <name>A0A6A7C1V3_9PEZI</name>
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        </lineage>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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            <begin position="274"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="654" mass="70578" checksum="1A9073BA06B336E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C265</accession>
    <name>A0A6A7C265_9PEZI</name>
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            <fullName evidence="10">Mitochondrial inner membrane protease subunit</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="12" type="ORF">K470DRAFT_215860</name>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="181" mass="20139" checksum="AD4812598A039CDD" modified="2020-06-17" version="1">MPSNSLSRGVSLLRAPFWALTLTLLLTTHGVDITLIRGTSMVPTLPSGSLILWNRHKPTQNLERGALVEFYSPAAPETSAVKRVVALAGDEVTLDSGRRPKRVRDGDENRRWDALGGRVRIPEGHVWVEGDNRSLSRDSNWYGPVSMGMIRGKAVCLLWPWREIGRTPWVGFKSQTGVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C268</accession>
    <name>A0A6A7C268_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_256930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C268"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="500"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="707"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123317" checksum="3E86E4D34EB93763" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C295</accession>
    <name>A0A6A7C295_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_34056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C295"/>
    <dbReference type="OrthoDB" id="4501190at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="16428" checksum="C9365C3652EC5CBB" modified="2020-06-17" version="1">MPRFYTDICDVSRTRNEKAPRSKPEKKVCVCGKSHLWEPFEYLKELLSPTGRSGLDPTNIRQVRERYEAISPNTKKLCNRKERRVKMPRMFAVISTNSGPQISDEELKASVILDQGSEVHIANDRNRFVGFLELVVESSIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2M4</accession>
    <name>A0A6A7C2M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_269636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2M4"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="105"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="38746" checksum="DECDFDE76731E7F1" modified="2020-06-17" version="1">MIPRRTLGAAEWATGRRWRSFLAPPFLLDDYTPRYQLLSSTQAALKRSEAYAHLRNCNLCPHRCGVNRYERSGTCLVGADVLVSTIAPHFGEEPCLQGHNGSGSVFFSGCNLRCVFCQNHDISHQRSGFSLTPEELAEWYIKLQDVGSVHNINLVTPEHVVPQVVLSILHAREIGLKLPIVYNTSSFDSLESISLLEGLVDIYLPDFKVWDRATSRRLLKADNYADVAKESIRAMHSQVGDLCFTADGLAKKGVLLRHLVMPGLEDEGRQIMAWLAANVSQDLYVHVMEQYHPRAHVGKTKRVGGSTKYVDINRAINPRELETVRKSGEAAGLWRFLDPAGHGGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q7</accession>
    <name>A0A6A7C2Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">K470DRAFT_256636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q7"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="319" mass="34961" checksum="E97C76A159C7592B" modified="2020-06-17" version="1">MADAVQTLQKTLVSEDEPLAKRFRALFSLKYLASQKPATSQTVPAIEAIAAAFNTPSALLKHELAYCLGQSGQDEAKPFLRKVVEDRAGDAMCRHEAAEALGALGDQDSLDLLRQRRDDAKEDEVVRETCEIAIERIEWEHSDARLKERLRPSDFTSIDPAPPVAEVSSVSALEQTLMDTSLPLFKRYRAMFALRDLASPPDRPAAVSAVQALAQGFKDPSALFRHEIAFVFGQLSHPASIPSLVETLSNVKEASMVRHEAAEALGSLGGEEGVEEVLKRFLHDPEPVVRDSVVVALDMAEFERNGEREYATIPVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2U6</accession>
    <name>A0A6A7C2U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_294562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2U6"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="352" mass="38448" checksum="02DD2E5875B75158" modified="2020-06-17" version="1">MPICLATCNGPALAAWRLRSRYGSIMPVVYDPLRLTSNLAGHRGRPRLHPEGDPQASSSSSVRRGPVPPLTPTRTRSTRSVEGSSREVVAIGSETAAALLDLDLIVIKCNSAFNEAAFKDVRGLHISAFATPADPESFQNLRNRLRTEREAREPAFLPPILPQGQDPFGDISPLEAERYTEGFDNHTFQWIFGPHRSSAYTLTVRVRLAKASSYFVLVTLPTFQSSLAGRSMMQPSMAQISSATPSSPAAGSPHPLSSPYAMPPWRLLPAGPLIASSSSPSSSSTAYTPLHPPAGFTRPEYQLPPIRVLGPPIRAPQPRPLDESGDEGDDRRSPKRRRVSIHDVLQRPDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W6</accession>
    <name>A0A6A7C2W6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_257394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W6"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025349745" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="240" mass="26049" checksum="45F7602969C5F4B4" modified="2020-06-17" version="1">MKYSIFTPFFLATALAAPTPVEVDDLSEEGNTTLVERASVQGFDVSSFQPNVNFASAHSGGLQFVYIKATEGTTYRSSSFDKQYTDATKAGFIRGSYHFAHGSEDPVAQAQFFVKHGGGWTADGITLPGALDLEGTSSSRCNGITVSWVKKFSDEYHSLTKRYPVLYINKSWWNECLGGSTAFKDTNPLWLASWTSSLPSLPGGWSKVTFWQTNDKNKFGGDSDVFPAGLAALKGFAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C322</accession>
    <name>A0A6A7C322_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_269731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C322"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="70" mass="7560" checksum="4E613100EEB3316F" modified="2020-06-17" version="1">MPTINVSLKEGANADQLEAAKKQVQDQGGKITHEYKLVKGFTAEFPDDKVQTLASNEALNVEADGKVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C359</accession>
    <name>A0A6A7C359_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_26139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C359"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="12459" checksum="D74F8530F9085BBE" modified="2020-06-17" version="1">MSVPRPLILTLQQIQSKVFNTIFNPSALRLGNKILKQPLRGALLSAYYPRRVATFRELKGLYPNYDLYDEKEETRLEDLEARKKRGKGNPRKKRSGAESRAKGGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C393</accession>
    <name>A0A6A7C393_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_269501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C393"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025636099" description="Acyltransferase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43256" checksum="29ECF1C74FF6AFFB" modified="2020-06-17" version="1">MGWLWMFLQTFAPAAVAHSYNTTGPEHQLVLRKSLSVLFWNDSLIYSSIIFLSARTISLPFLLNSTRLRLASSVLRRGIRLWIPTAMALIICYAIFSKTLGTEYMNAFSAQTQNESMTKDLYMLPNSLANFNSIFDIFWTLWVVSVIFQQSYTVFMAVAIIPYTRNSWRLKGALVFILAAWWVYSWAWFSVTGLLFADLVVNYNFKAIAQMHRLETYAAGATCLIAGFTMQFLWVAAWPELYTAEIKYHTGVYQTGGLWLWNDATAPLLRADDYLVIVGFNLLLESTDVLQRIFRSRALVFIGKRSFSYFLLQSIIAYALGIKLVMNIIGGSMDTYAKASAVAFIVCLLVTIGAGEVFYWVIDWPTQRFACVVFDWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3A8</accession>
    <name>A0A6A7C3A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_245460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3A8"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C410"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025516123" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="15755" checksum="87A987775820E0A0" modified="2020-06-17" version="1">MRIMNLLPIFLLATLTSGGETTTQACVPSSSGAPYPLYIHCPSSSNTNSDEDYLESVIGTALPRTLYDLLETNLPSAFAAIKQELYAPTATGEPSWFTHMPTRAQTLLDPGVVAYEKTHNFALPTGGTGRRSRAAALGVGVAVGVGVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C453</accession>
    <name>A0A6A7C453_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_284731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C453"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="213" mass="23990" checksum="EFF5EEC0CA005439" modified="2020-06-17" version="1">MAQRTFTALVTGFEPFEEEYPVNPSYEISQSLPPSLADHHVKINIVPLPSPLRVSYRHVSELMPAILDSYAGSVDMVLHIGMYSGHAYAVERFGHANGYVRPDLYGALPTEQDERLGEKLETSFRVQNVIRKWQEETCTAGYNAAECCVSEDAGRFLCDFTYFTTLAWYGKKNKRFTATFDRPVLFLHVPADNSVEKGRVFAECLLKASAACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C457</accession>
    <name>A0A6A7C457_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_263463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C457"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="449" mass="50573" checksum="EF0A702B8E9BBB0A" modified="2020-06-17" version="1">MELSVGLLSIALVDLVLGYILYQNTWHPLASVPGPFLARLTRLWLVKHSWDGDMHTTMIELHKKYGNLVRTGPNEVSVCELAAVKQIYGAGTRFRKSNWYSVFQGHRKFDIFAERDEQIHAAQRRLVSRAYSVEALKDLESEVDSAIGVFLNCMRHQQDRIVDMAKWVQLFAFDVIGDVTFSKRFGFMVAGSDDGSIKQINAALKCAAWIGQVSWLYWLHDALMPYIGNHLAITVRHGSIRNFAVKEIAARQDRAVERKDILSKLRATQKEKPLELDDVAVTSMATSNIFAGSDTTAISTRAIIYYLLKNPSCKQRLVGELLTLRDQGKLSDPVTMAEAEKISYLQAVMYEALRLHPAVGMNIPRVAPPGGANIAGVHVPGGTIVGVNPWVLHRNRDVFGEDVEAFRPERWMGEKQGDMHRFFFAFGSGARTCMGRNLSWIEMWAHQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4E5</accession>
    <name>A0A6A7C4E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">von Willebrand and RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_269030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4E5"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="441"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="105004" checksum="2251447B6675BFCD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4I9</accession>
    <name>A0A6A7C4I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_200311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4I9"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="19118" checksum="1C29930B36E8BC3F" modified="2020-06-17" version="1" fragment="single">SENSSRALRGELYYAFTPELVAARRRAKIACDRYNSLPAGASRRDQVHALRQVLGDGTPLPEDPTGEYGDEPWVEPPLRIDYGTNVTLGKGVFINFSCTILDTCKVSIGDRCLLASNVSLFSGTHPLDPEVRNGTAGPEYGKEIHIESDCWIGGNVTILPGVRIGRGSTVGAGSVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4J2</accession>
    <name>A0A6A7C4J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_269489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4J2"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="94"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="458" mass="50989" checksum="5996D2993315EB05" modified="2020-06-17" version="1">MSSNVCLRRVVAASRPAIRSVTWLQQGRCLRSLGLRSLSASRPVPSLPQTRALPTQMRLFSMSGHCREEQIIKVPQMAESISEGTLKQFIRQPGDYVEENEEIATIETDKIDVEVNAPAAGTIKELLVNEQDTVSVGQDLIRFEVGGQPGEKSESKEESKPKEEPKKEEKQPEKEEKQPPKEEKQPQKEEKQPQKTESKQESKPKPAPKQEQKQAPKQETPFGNREERRVKMNRMRLRIAERLKQSQNTAASLTTFNIVDMSAIMGFRKRYKDEVMQRTGVKLGYMSAFSKAATLAMKEVPNVNACIEGPDGGDTIVYRDYVDISVAVATEKGLVTPVVRNAEGMDLVGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKDMPVAINGKVEIRPMMYLALTYDHRLLDGREAVTFLVKIKEFIEDPAKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5C7</accession>
    <name>A0A6A7C5C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_212350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5C7"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="193" mass="21586" checksum="E71C6F63B72E95D0" modified="2020-06-17" version="1">MPPTPAPEPQWILILTGPAGSGKTTVAKWLASQLQWPYLEGDTFHPPANISKMASGVPLTDADRWDWLITIRESALAALQTSSPPKGVVVTCSALKKKYRDVLRIAGYHHPTIHIHFIYLHVSEETIRERVRARQGHYMKLDMVHGQFEALEDPDNDEHDTTTIEASESLPKVEEKVMSTVTKIFSPPSSSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M1</accession>
    <name>A0A6A7C5M1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_256221</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="242"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="575"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91719" checksum="F882C6AB832D3AA8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C651</accession>
    <name>A0A6A7C651_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor/non-receptor type protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_256140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C651"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="313"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="396" mass="44396" checksum="C973B966D548EC91" modified="2020-06-17" version="1">MPPQLPNYLLLPPTEIHSQFRHLEHMHRERHSCPQGRWTLPSTTPNRHIYMSRNRYENVEPYLHNRILLGGYDDPSSPQRSEVAGDYINASQICLGSRSYIAAQGPTASTAGHFWRMVAHNLPEEREAVIVMLTQLRERGREKCFPYFLGAGGGDGVGSGAGGGRTGEVAVGGGGEAEGRSLRPRSAPSPTTPQGILPIPREENDPSLFEAELHTLSTSFHEASKSEVRRLRLRYRSRATKGEWRYKEVNHLFFSAWPDFQVPKGEDREALVELVGLAARVASPTQTTKSAGTKTAKRMSTPSSLGRDLVSYDGSPRVIHCSAGVGRTGTFMALDSLLTRLYSGELDCLPQDCNPVWETVLRLREQRMMMVQTLDQLLLIYHVLRERWVERSRHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6E2</accession>
    <name>A0A6A7C6E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_211549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6E2"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Bloem J."/>
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    <dbReference type="PANTHER" id="PTHR13213">
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6T6"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40205" checksum="8B74010BE92EB4DD" modified="2020-06-17" version="1">MPSLPHRNTLVEGASSTAGAASASRSSRSEQEPVIRFIPHMEPRAARPSLQFPAVERRLTNAHSVLRVGRYSDRDNDPSALSVGFKSKVVSRRHCEFSNSSGQWFIKDVKSSSGTFLNHVRLSPPGQESRLFPVNDGDVVQLGIDFKGGEEVIYRCVKMRVECNRGWQKALNAYNTTAHKNLLRSTGISSNSRGSDAGSVSSSECSICLNPVAPCQALFVAPCSHVWHYKCVRDLIQRRHFSCPNCRLISDLDADVEPPEGCFDQVENGQPAQNEGESEPADETQAGAATEAPNDPPVNRAAASSPPRDLLSNTVVAPVRSGTPMTTETFALSAGVLDGGPMTPRNDFGPFVLDSRMQSMIPDDENPPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6U5</accession>
    <name>A0A6A7C6U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_211426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6U5"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="217"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="371" mass="40910" checksum="902FDE64DC62F82C" modified="2020-06-17" version="1">MSSSLHSFIAASKHNLQKPPNSDKSKTAFVIGNESADLDSIISAVVYGFLSPSPTTPIANILSSDLALRPELAALFKHADIEVKDLVTLDNLHNLPPPGDTEWTLVDHNAFQGSLGNRYSKDVVGLIDHHVDEEKVPSSAKPRIIEKAGSCTSLVVNFCRPNWGKGDAKTAMIALGPILIDTHNMQSKDKVTDHDREAVEFLEGKLSGQNFDRDAFFAEINNAKTNLDGMDLNGILRKDYKQWIVGDFTFGISSVVKPISYLETKAEKMIESMKSFANDRDLDIYAVMTAYTNVQGEFVRELLLISLNDGKAMEKVKKIAEMGSTELQLEESGTKIANSCVPWVRVWRQKNVEASRKKVAPLMRKALGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7I1</accession>
    <name>A0A6A7C7I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_292847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7I1"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="45927" checksum="8DBF43022A7027DC" modified="2020-06-17" version="1">MESEQLSRPRRPGNTIHPTIRAMGRRILSQEQQTSPLAVSPRVQRRDSAASSSVQLGSGPITPLRLSPQPASAMPSTPRSGSPRSWRLSDEEASVGTDSWSVDAETGLVMPSIAVSARHPLTERGQQLGRIKVMVVGRRGVGKSSLIRSIVRASEDVVHSTPAAAVAEYPDVWEVRASTRTYPDWWKERGCAMGEGVLEPNLCLVDTPGVEDERGRSQIMSYFAASHPGHLDELSELETLKLLSGEGGTHVDAVLWLFAHDEELSCTASKVIRHMSLYTNIIPVIGFADTCADVQAAKRRMIAQLAGLPSLYSLQDKEEPYAISSAAGIDDEELDASVLMSSLYEAPPVPSDLGKLVARLLDPSNAARMRHTVAAKFVGQRAEKRNGRLGGEFHLDPDGVLPQLMKKAIALALGAVALGWFYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7K4</accession>
    <name>A0A6A7C7K4_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Putative allantoin permease</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_210793</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="533" mass="59807" checksum="DB909C7F12FFFC07" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7L4</accession>
    <name>A0A6A7C7L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_225993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7L4"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="352"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="47665" checksum="34CC4F09B1FBFA28" modified="2020-06-17" version="1">MSLFKRPDWAKNSSTPTRENIFSHSTTYAEIIAEEHRKKRERDKEKAMQNGEKKVTPQPPTPEGDVMPPLEAFDRHVAQNGVASQTPGKTQTVTTVVESDDDDIQIVAQVQKVQRDGTKRRRITPNGAESLPKPVLRAHTTYKPIAPKAAPERPSDRSSSPVRKVPPPLPVIHAKPKVEEPKVPQSDSDSDPDIAALARRARMRRSVATSQTPDASRRDTVPTVSLLISSPIEGTKPIIVTRKVTQNLQEVRLAWCKRQACLRVGFNEIFLIHGMRRVHDITTCRNLGLEVGQNGELRMKGRDDGEVGQIALRAVTQEIFEELQRESLKPRPTQEEPEGEPEPDPEAGNNFRISLRFKTVREPYKLRVRPVTKISKIIDVTRQHFNVPEEQTLILEADGEALNPNSIVGETELEDEDCIDVYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Q5</accession>
    <name>A0A6A7C7Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein FCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_292661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
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        <property type="entry name" value="Fcf1_PIN"/>
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    </dbReference>
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        <property type="entry name" value="PIN_dom"/>
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        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
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    </dbReference>
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        <property type="entry name" value="PINc"/>
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    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="193" mass="22359" checksum="F6293691781E9E58" modified="2020-06-17" version="1">MGTAKRTRKFAQVKRVISQRDSRIRKNLVRTSKPKSDKDDNVVREVPRMQSNLFFAHNTALVPPYQILIDTNFLSHTVHHKLPLLPSLMDTLYATCNPIITDCVMAELEKLGQKYRIALQIARDERWERLKCDHKGTYADDCIVDRVMKHRVYLVGTNDKDLKRRLRKIPGVPIISVARGGYKIERLPEAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7W3</accession>
    <name>A0A6A7C7W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="138" mass="15418" checksum="FC9951FC3F98EB10" modified="2020-06-17" version="1">MAKVPRNFRLLEELEKGEKGLGAESCSYGLAEGDDLLMSNWTGTVLGPPHSVHENRIYSVIIYCGPEYPDKPPQVSFTSRINLPCVDARTGKVDLSKLPGIHSWRREFTMETILLELRRFMAASANKKLPQPPEGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C4</accession>
    <name>A0A6A7C8C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_210231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10253204at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="86"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="297" mass="33784" checksum="F4487916A6C053E7" modified="2020-06-17" version="1">MRRRLDREKRDYLYRRALVLADADKAEKRAALKKSLGSGKPLDPNIANDRQLQRDYKFDETRADRTAEEELELDDEYSLLSGVVDPRPLVTTSRDPSSRLSTFAKEIRLMLPTGIRVNRGNLILSNLVNSAKSAQLTDVIFLHERRGTPDALTLSHLPHGPTARFSLHDVVLRHDIPNSARGTISESYPHLIFKGFSTPLGTRVQKILQHLFPPVEDTKKPGTRVVAFINMDDCIVVRHCLYVKTGPNPKDVVLSEIGPRMTMRLFEIRQGTFDEADGDVEWTLHNYTRTGNKKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Q6</accession>
    <name>A0A6A7C8Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Q6"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="329"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="52921" checksum="CD8FC5FF4A9A6553" modified="2020-06-17" version="1">MHQTSSRLLRMTEDDRPYTRDFKDLFATLVVSLPLTTHRVRFSRVDHSFTTEEALTNLGSLKFSQSNRMPDPKDPSRIVTTTTTTFSMAKEMARSVCMRFLEARFIQSVEGKTDFSSKGSVWQLTPKGMYILQRFCQRNGIHQRHVNDMLESPRNMMQLVILERDPDTDKISHDEATVHVIFRRFAGNNGPNVRQNVTSDSDSINDYATGLVGVRVQRARRGDKESPYIFTGKAAFDWIMSCCTTVDKREVFEIANAFLQLGLIVPLDSDYRPINNATIRFAASKHALHAVTTKGMRVANWIADPVAPSNGKPSTLRPQGVVRDSNVNRMTVIIRDPALRLLFREYLVETHCEENLAFYLEVQAFLLEFNRAKQNHKVLPMDVVRETLASAYSLYNAFLAPGSPCELNIDHNLRNALAGRMTQAVTEDAQMMKSLEEVAVLFDQAQSSVFKVMASASLFSSSQFFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Y3</accession>
    <name>A0A6A7C8Y3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_240831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Y3"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="188"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="452" mass="49734" checksum="05F9F1FDE0A249A9" modified="2020-06-17" version="1">MPCFKGLSINIHTADGPLPELALQRHSRSSRVSAYIPVPPAKLRPDSVSGKPEQSTFAISITLLTPGLKIPNSAPEPTPENPDPQPRVVGALASDGQRNADPIAPYIPSTNHPNETLAAYIYFDGRPKEEVATLLRRGEETWVNSRWVKSDNGGLAEREFLFREIGLERYLNGLDLTGRKNNGEKSQARQKRLSRQAQREQSRRSAWSDNKTPDSPPVKKKDEGGDDSDAEEAEPEAAGQIKVILFRVLASGEVRHGEYLPQFSANEDDDQSNTNDDDVDHTTSFAKPRSLDPSSISTQTVTGIDTPGLPYATFTFFYRGERQLRKMGILPSSPEKNGVANGKHRSTDFSKLGPLTSFGTVGFSGYRDPADKKSKKGGNDGADSDAEDDEEADEEKRLRLGKDVEDASKLLSPEDAKEQGELAEGVEKIRLKRQRSVDPLTDLARKTQRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C942</accession>
    <name>A0A6A7C942_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor eRF/aRF subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_292633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C942"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="430" mass="48289" checksum="83F9B30E35D5830D" modified="2020-06-17" version="1">MSQANDADKNIEMWKVKKLIKRLEAARGNGTSMISLIIPPKDQVSRINKMLAEEYGTASNIKSRVNRLSVLSAITSTQQRLKLYNKVPPNGLVVYCGEIVTSEGKERKINIDFEPFKPINTSLYLCDNKFHTEALSELLESDQKFGFIVMDGNGVLLGTLSGNTREIIHKLSVDLPKKHGRGGQSALRFSRLREEKRHNYVRKVAELAVQNFITNDKVNVAGLILAGSADFKNDLNQSDMFDQRLQARVIKVVDVSYGGENGFNQAIELAAETLSNVKFIQEKKLIGAYFDEISQDSGRVCYGIDDTLKALEAGAAETLIVYENLEITRWELRSSSGSTVIVHTNGAQPDREQLTDKETNTEMEVIDQQPFLEWLADKYQEFGAKLEFVSDRSAEGDQFVHGFSGIGAMLRYKLNFEQLAEDSDDEFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C962</accession>
    <name>A0A6A7C962_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">K470DRAFT_209019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C962"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="24613" checksum="2D598749B3C16E31" modified="2020-06-17" version="1">MRLQEFSLHSIVPAARVEQVLAILAGISGMQAVRICEQTVLYRQLSPTKGQQRAQYHKLIRDVLNERSSWILRAEDLPVAGNPTVISRSVLVNVAGSTEVVEQYREAGGNYKFVNQYLLQGHRFTHHNLNIRVGQILCTPKEVGKSEPLEAAPPGVDQCSALDPSGAYLFEVSGSVNDNNNSDLTNAVRKELAEFQQKMKGVLDVHAPDRLSMDPRVKQTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C964</accession>
    <name>A0A6A7C964_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_268364</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C964"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025593101" description="Crh-like protein" evidence="18">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="266"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2863168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="431" mass="43914" checksum="47C68E9C86F19EF0" modified="2020-06-17" version="1">MRFISTVLAAALPLALAQTSSGCNPLKATCPEDVGLDASSFTSDFKKPNANASWSAAAYTDMTYGQNGAEFSIQKATQAPTVSTDFYFLFGRVDVRMKAAPGQGIISSIVLMSDTKDELDWEFTGGNNKQVQTNFFGKGNTTDYNRATYESVSNPQDEWHTYSFDWNSERINWLIDGQVVRTLKNDDPLTNGGSNYPQTPMQLKLGNWCGGCDGQSPGTVQWAGGRTTFGDKPYVMYVDSASITNDNPAKSYRYGDKSGSWQSIEITQGNNSTSDSSTSSSAPSSKPQGSATRSSGTSVASTATVAPSSSVSVADMRHETQVAVSITESAGTTKAIGPVATGGAATGTAGTVGSGMGAAPYGMNGTTAAGGASGGVAGTAGGAAGTGAAGPTGAGVSSSSSQPSAQPNINGAAGKQVAAGAVAFAAFAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P0</accession>
    <name>A0A6A7C9P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA26"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="292" mass="32664" checksum="FBE50135DF26E8A3" modified="2020-06-17" version="1" fragment="single">TTPTTVQNLPPVQNLTPLQQSMHQKLISARFRHLNQTLYTTPSTTSLSLFTSNPQIYNDYHTGFRQQVALWPENPVDIYIHTLSNLRKPRGRDVVIADLGCGDARIAAAMAEKKGVKVLSYDLVASAPGVIQADISSLPLPGGSVDLCIFCLALMGTNWVSFVEEANKVLRMKGEVWVAEIKSRFARRGRGRVEHSVGKKRKTTKGDDDDDDDDEEVLRTEVDGVDAPEETDVGPFIDVFRRRGFTLKEGSVDLRNKMFVRMEFIKTGLPSTGDVDPDEERKVLKPCLYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAI7</accession>
    <name>A0A6A7CAI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_55414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAI7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="25447" checksum="C280FE1248506E3B" modified="2020-06-17" version="1">MSAVDPVSVTTTVTVLGPEVSTMVLTLVTDATGVPDEVVGVSVTTVSSVRVGRVQVKMSAVDSVSVGRTVTVTVSGPEVSPRVLTSVMVTTTGVPDEVAVVSVTTVSSVNVGRSQVSILGVESGPVKMTVSVGISEVSPTVVTSVTDTTGAELVVTEVSKLKVGNVQVSIPVSDEEGLLLTAVSSDKVGSVQVSIPVSDEAVSSDNVGSVTVKSFCPWLLSVTTAVTLSVTVTTSGGRLCNWLLGVVTTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAI8</accession>
    <name>A0A6A7CAI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_273864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAI8"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="27480" checksum="22739EB583FB80E2" modified="2020-06-17" version="1">MPDSTTTKAATIQQDEKPDFSKPLPRTSLPSEIQKTLDSEERWWELFGSRSDRPDDSTSSNVRYAGYARNLRTILRSAHRYVAYTSDIGESFRPVAHPYLVKSAYGISWAYIAGDVGYEGFKAYKRNQEASYTPPLDRWQTVVVQRGIFQSIASMGLPAMTIHSVVKYSGRAMKNVKNQRLRTWGPIGLGLSVVPMLPRLFDEPVERATEWLFYNTFKAVGGEKAVGGLIVHDAVPASGIKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB80</accession>
    <name>A0A6A7CB80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_253985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB80"/>
    <dbReference type="OrthoDB" id="5272500at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="257" mass="29248" checksum="DA9E5311E0900E21" modified="2020-06-17" version="1">MTTTSPSHQLLLSAEEEDVLAQSEGFGLLRDHLALHYREPFCEHHQNSLEGARWEIARDLLHACLVPLVEVYDLAAVLAARHARPAQRPEEVFTGAARSAYVWLQTFLSHQRNRDWCYTRGCPACVVISVLNTESTLRMLYVACLLSNVHYPFTIEGPTLPSFFFYLERLRSAVMQTPRFDDNLLDMLQIRADQIVTSIEDLMLQALELDRCGTRAPRFKSADEKYRIDVAVQRCREMSDDDGMSSCCEAPLPQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBI8</accession>
    <name>A0A6A7CBI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_208336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
            <begin position="4"/>
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        </location>
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    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="70" mass="8051" checksum="ECEF8D65AC0B0C69" modified="2020-06-17" version="1" fragment="single">MTKSYYSLLGLKDIAGKRPTQEEIRKAYKAKALQFHPDKNPDTSAAELFKEVGEAYEVLSDPKKRSQYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CC05</accession>
    <name>A0A6A7CC05_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_239431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rcat_RNF216"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF26191">
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    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="502"/>
        </location>
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        <location>
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        <location>
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        </location>
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            <end position="22"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="553" mass="62745" checksum="015D718FF81A201F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCC8</accession>
    <name>A0A6A7CCC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2864525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="21111" checksum="1CB65642E06E4402" modified="2020-06-17" version="1">MRPTKWDTFFCELDLGAVRKLARRASEDEPILQVLETAIPKLIKTAHETSRSDSVTFFRRYVSRSFLKQDRLIEPGMLKKLQVSGYIECKNFWTLMCNSFFSVSKMDGPRPRYRFTDEQVMKIIAVFETANQISAAAEGDEDVNEAKLEDALLDFFLKLLDQPLNDKVHRSSLLSFIACTTITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNL3</accession>
    <name>A0A6A7BNL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_261166</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
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        <property type="protein sequence ID" value="KAF2857050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNL3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="46"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="440" mass="47951" checksum="F26EFD9C06B326A7" modified="2020-06-17" version="1">MYVNSQPTTRKFVSRPKQNYSGNHFKPVAGSNALLAPTSVLSIKADDTFPESSSGPPLKRPSLGHHSSSTYSHNPSSKLPETFRNVPPLPILQPQTYQPLSRIKSSKKSKIQHESLTSSINLPDPQRTLPAPEPESSSNILTSLRNPSSPPSKSSEADYPSSTASSSTLGLTPSFPPRTAINLLSESDLVSKWSPSDSSPISDERTLSWNLQRFSSGWMGREEEEEEGFPFSQQSTPEVQMPMSPLLPIYAREGRGRGGASLTGWGGREALSLLPPFADREVSPNAENKALSPLPLFSGEDSFAGPHTAPLGCREARQAALPDGREAKQAAPRGSRQASPPAKRKSGPLSPPTTAHTRETYVSAATPLPLPTPDPNFHRESHANQGRFNGERGGGKHFRLASKVCSHVLPRKKGGHGTGRVKRFLDLMWGKRRWKRRERS</sequence>
</entry>
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    <name>A0A6A7BPS6_9PEZI</name>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="229" mass="25432" checksum="360DDC234960EA01" modified="2020-06-17" version="1">MGVSMSCRTRKIAPNSLSASDSFPISEYRRLRYWHVLNALAGSVDMKPLFDSDVTKGAFFISTLPESLDNFMDNLNTKGISSFSEILDPLQDIIDKNALKDPMVTALHAATSKRKHFRPTATSSDEYCTFCKSRGFPYKGHSHRNCRRLGKAKKDRANRGFKRHQGVKQSSTSPKDNAYKASAQEAVALITFSDATNTAYLGKVPPPQPARYLDTAASKHMSGVIEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPX5</accession>
    <name>A0A6A7BPX5_9PEZI</name>
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            <fullName evidence="1">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_223524</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006048">
        <property type="protein sequence ID" value="KAF2857353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="438224at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="326" mass="35694" checksum="06503C4D35C9E1FE" modified="2020-06-17" version="1">MTAVTVPYSSLKSQTIPLSTLESAFGPSSLGIIIISDLPPSYPSLRSRALNFSNTLAHLPPSTLSALERPSAKYSIGWSRGKENLGTGYDELKGSFYFHPVQNAALQTKARDLYPDREEMVSPNIWPASLPGFEESLMTLSNLIVDVAAEVAKACDRFGQENIEGYRPKLVEEWVRGSVATKARLLHYYPSGGEEWCGSHKDLGALTGLTAQMWVDESLCHQGEEEARELDAHPNDPTAGLWIVDRGGRHVHVDIPRDCLAFQTGEALERVTKGRFKAVPHYVTAGKGGGQIARNTLAVFTQPNLWENVDGVTFADLATERLKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPZ6</accession>
    <name>A0A6A7BPZ6_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPZ6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="106" mass="12098" checksum="71C683209BDDF072" modified="2020-06-17" version="1">MPDTLCHICHRIGTGKSTMKMPYSNGVHFLTAMHQRNKNSLRHDPEEYQEALYFEESEDADARMRLVLESRAQNAKILARQATTQAASTVNPAPFWNMNAQALYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ49</accession>
    <name>A0A6A7BQ49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_273342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ49"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="42326" checksum="0B5DB9DA02F552D7" modified="2020-06-17" version="1">MSAATPQPSGAESWMDPGAGMKGDYNDNNGTLRLLIAISASISMYSAIELVTSVLLTFHRYRGCYFFSLLTAAAGILPYSLGFLLKYLRLIPGKLHMLPIVLLTLGWYPMVTGQSMVLWSRLHLVVHGAQGQKIVRATKWMIIANVFLLHLPTTVLTFGSNGSIQTEKFVEAYTVMEKIQMTGFFLQESLLSSIYIVETVRLLQTSLKPRTRSTMKHLIAINVFIITLDLLLLALECASLYILETLCKGIIYSIKLKLEFAILGKLVRFVSGSKEQRSLQEDPLRSVDLFSSRRSGSQDGAIHVNDFVDLSKVTSNMSYPAPPPTTRRGSQRDKSLDYGLARFEHNEGVSRLSEEELSSDGEDEDDAIAGAEEEQPSLAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQF2</accession>
    <name>A0A6A7BQF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQF2"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="30946" checksum="7AA0477A8C8C04A9" modified="2020-06-17" version="1">MASADVVRRPLGASRRGAAGVDGKRKQNFTHWMRKMTSFKGGDARHKKGKPAEPEAPAASSTSLPDAAPTVHSDGGNSGSKTATTTTVPDSTFSSANPSEHSLATTLTTVQSHAATDTQQPPQQQHTLAVAQTHTLPLPRQPTYSAATANNLLTDNASILTLASSSKQRSRRSMDTDASVRAIPPSSVWGGSRESLPLSVLSGTGPGGGHTSLLASERNSYHYSSPRLSTKEYADARSLRSVSEGRPLSDGGGRPGLDSRSVSQNQLGAAVDAPPVANRLIRRSTDYVDAQEEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR80</accession>
    <name>A0A6A7BR80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase A22B, signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_290827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="452" mass="49666" checksum="3555838C3B18AE12" modified="2020-06-17" version="1">MDYSTFANVLAKAYSLILLHLHIVFSALLPIYTGAYASLSRPQSAGKPKKTSGNRKGEEAGCAVPMERLSATDAILLPIVGGATLSGLYFLIKRYGAALVNKILAWYFSFISFHFLTVSIKDALNVVANIALPKYFAQNGRLYKIDSQGNQVAFADGKTATPRWKAIRMGLKQKYLVKIHVSKIVDIKVQLTPVNVFASFVAIALIAYANAVGQPWWLVNLQGFAICYIAMQLMTPTTFTTGALILFGLFCYDIWAVFFTPMMVNVATNLDAPMKLLFPRSENAGAETPSKSYSMLGLGDIVLPGLNIGLALRFDLYMHYLKKQKLDRDNKVIKAPYVSVAGNFGDRFWTAGLPPSDKPAQLNVSFPKPYFTAAMVGYVMAMAAAFSVMAIYEHAQPALLYLVPGVLCAIWGTALVRGELKQMWAYSEMIKKDPTAAKTQKPMFGFSITRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR99</accession>
    <name>A0A6A7BR99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR99"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
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    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
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        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="270"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="37397" checksum="897D0C186DA6F865" modified="2020-06-17" version="1">MSTEDVHADDSHIEGVTEHLNNLNVEDGPRSDDDYGQAQLTLRAIVTSKEAGVIIGKGGQNVADVRDKTGVRAGVSKVVPGVQERVLAVSGTLDAVAEAYGLLADGLVKGAPAVGMGGIVANPNTHPIRLLISHNQMGTIIGRQGLKIKQIQDASGVRMVAQKEMLPQSTERIVEVQGTPGGVQKAVWEIGKCLIDDHERGLGTVLYNPTPRPQGGLAGIVNDGFGSPRGYNRTGNGADFTGMPAPFPARRHTVGDAGPPPPPAVEEGEEIQTQNISIPSDMVGCIIGRGGSKISEIRKSSGARISIAKAPHDETGERMFTITGGPTANERALYLLYENLEAEKMRRSSVPETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRT7</accession>
    <name>A0A6A7BRT7_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_12301</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phospholipid dephosphorylation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAP-like"/>
    </dbReference>
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        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="125"/>
        </location>
    </feature>
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        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="296" mass="32763" checksum="720F7006CAB82A32" modified="2020-06-17" version="1">MRSAIVGDTMPTDGGLWESCQRVWRRTFAGEYAALVLLAVVYAVVRLPTEPFHRLFRLSDPRLQFPHADVERVSVPMLFIYALLVPLCILTLWALILRPAVHAVHVTFLGFVSSVFLTTFITDILKNAIGRPRPDLLARCKPALGTPRDALVSIAVCQETKHHLLHDGWRSFPSGHSSFAFSGLGYLAIFFASQTLALAPRASLLTTLACAAPLLGAALIAISRLEDYRHDHADVICGSLLGLSVAYLTWRRQYPSLLSSECDMPYPPTSSRGPSPPGIFRTIRDEEEGLIEERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRZ8</accession>
    <name>A0A6A7BRZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2858000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="690068at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="182"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="42951" checksum="3EBDB4CCF99A5996" modified="2020-06-17" version="1">MSNACIKPDPEYLENFPLYSPEHFGSLAVNPASLHNTPYLPHSQNFLGAAIPDDELQDLRLDQQYDVNGMNMAFPPSYASSMHSPQQAPMSLGVQPRLRADGKMTHRHHGSLGTGWESTPSGQSWNESPPFNSPGNHAMHPISEVLKTGHALHHQHQTPSSLPTKIERSTGPYQSQEAKRRKRRESHNAVERRRRDNINERIQELGTMIPQHRLEDDRVRKHLQTNAPLSPPLATGRRSNGLGPLPADEREKGPNKGDILNGSVAWIRDLLWYFQTKQAQEAQLKSLVNGLGGTWPFDSSEEERRMTGELMEVLQRHGPVGFNSYSRAPGSGLRVPGFTNMAGDSIESASSSLPTNGHPSVSPAAAGSSGSSLAPGCWDFQEEDDFMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS57</accession>
    <name>A0A6A7BS57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Activator 1 37 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
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        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="37799" checksum="78019BBB2138EDA8" modified="2020-06-17" version="1">MAKAGSSKDVGINGAASSELPWVEKYRPVYLDDVVGNTETIERLKMIAKDGNMPHVIISGTPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPAGRHKIVILDEADSMTSGAQQALRRTMEIYSGTTRFAFACNQSNKIIEPLQSRCAILRYSRLTDGQVVKRLYQICKAEGVEYSDDGIAALVFSAEGDMRQAINNLQSTWAGFGFVSGDNVFRVVDSPHPVKVQAMIKNCQNQKVDEALDGLKELWNLGYSSHDIISTMFRVTKTMPSLSEHSKLEFIREIGFTHMRILEGVQTYLQLAGCVAKLCKLNMNPELFTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS68</accession>
    <name>A0A6A7BS68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_145479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS68"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="310" mass="35106" checksum="20B26B2756F8802B" modified="2020-06-17" version="1">MSAEEILTQIATSTDAAASNLTSRIAIFPGGISLLDLKNELFLAYLQFLALRNLVIIRGVKDNRQVKDMEEESITQNLAELRTWLERGIKPLEERIRTQVEKVLRCAEDADSAPKRVNPVEEESEGEDEEDEEAVARPLTTSFPTKEAPKVEEGKGKGKVYRPPRFQPMAMPEKKSKHALRTSRAVEEFIQADLADAPTAQPSIGSGLHDAGERRRAKERERKEYEEINLVRLPQEKKKKGRHGRDRMGDGLNVLEGLSGDYSMTSSKGREGALEKSKKRSRDVDAQEGAVGERFERKRKRLEKRSNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSU9</accession>
    <name>A0A6A7BSU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_296998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSU9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="28976" checksum="8A0C893632753A69" modified="2020-06-17" version="1">MQNCYMSGPHVGHTCSDLGKPSVCYMGTLCGSFPFNCVSADLSLSTGYEPGECLVIIRTIRPIDEVFAPPGLHQSDPLETLSALWQNSDPMLDNDRAPAILLTPPVISNQVIKKEEKRNEFEAASGQPINKYDVAQVVLDAPYVLFLEYPRDSHIRSIRLGPVRLSVLEVFGGGGWEELTDRPLIGSIVARIGLRLVQMGLDALTLCASLYGHSKELSALLQNKPWAVRRGLRTKTIRWQRTEHLGRHMMGCGLRRQDPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTG6</accession>
    <name>A0A6A7BTG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_133422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTG6"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="108"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="344" mass="37345" checksum="0EF08323397CD10B" modified="2020-06-17" version="1">MSDLLVTLSLIPAIAKVLVAVLLRLLSAPFRSGSRAPDIYRDVGYTAIRTLLNSVTAAQERLSFVNPPTEKIYLEFCEKQGFQPDTEVISSTGTKLHWLGPKSAAKTILYFHGGGYARGCSMAHWTWLFELQNLLRRSGHDVSVAVLGYTRSTLAPYPTQLREAAESLNHVLGFKSPRDLVIGGDSAGGNLTMAIISHMLHPHPDTSIPHVFATTDASVVRNKGSDLIGTGVAHRWSAMFLGPHASDPYCEALKAPPEWFANLPVLTDRVLLWGGGGELLIDSICDLAKVLKGVIGDKLEFVEEPMAAHEAFIMDKALGYGTRGEKAEGTAVIEQWVGRQLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK3</accession>
    <name>A0A6A7BTK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTK3"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="114"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="652" mass="74158" checksum="14265DEFC7ADDC34" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTQ3</accession>
    <name>A0A6A7BTQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTQ3"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPB6/omega subunit-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="168" mass="18910" checksum="2F3EAA82B61462F3" modified="2020-06-17" version="1">MSDDGDDAPMREFGDNEEFEDNLIDEEDFVDNYEEQDGAGDAENDANEQPNGTTKQLDSTDFDNVVAIDAGGQTQRDLNSVRGIKSKKIPNNKRTTTPYMTKYERARILGTRALQISMNAPVLVDVEGETDPLAIAIKELREKKVPLVVRRYLPDGCYEDWTCEELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTR2</accession>
    <name>A0A6A7BTR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_235826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTR2"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48856" checksum="A136AEEB76DD6983" modified="2020-06-17" version="1">MPAAKGPEWYLHQRFHVWTVYRRLMAVVISANASVISAMIVRTVSHPGTFSYDKAATAAGANILVSVLMRHEHIINNLFRLALLQPRWFPLVVRRSVAKIAFHYGGIHSSAGIGAIGWYIFYLVLVVRDFDGTVAEKAAMLSLIASVTVLLLCIAVSSHPYLRNRYHNSWELLHRFGGWTAVGAFWAQIIISSIVAGRHKGQNVGLMLIETPTFWFLSTITCCIIYPWLYLRKIPLETIPLSNHATELKFTDRQMTTCRGIRLSHNPLKETHAFASIPGTSETENGYSVIVSNAGDWTRAMIQNPPSHIWRRGAPTIGVMRLTSTLSPVVVVTTGSGIGPCLSFLNCFPDHNMRVLWSARTPMETFPGMIDRVHRADNNAIIIDTRRTPKPDFVGLTYALLKESHAEGVVVISNPHVTKDVVKAMEMRGITAFGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTS9</accession>
    <name>A0A6A7BTS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTS9"/>
    <dbReference type="OrthoDB" id="4812032at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="217" mass="23669" checksum="D8A2A4C3A0A32FEE" modified="2020-06-17" version="1">MESSVMSSTHEQILQVPNPGDDMDKTMKIVQALSSVVDEGKSIAAATGYVLATNKPVPPEDAAMSHMTPEQELAYRGWKSGADLPQIEWTVSRVDVPGGPQSDAHFSKRAAAMRVLFKDQDIDQQNAVWLTFNAPDLLPLVKAVEKILNAERDSTGGQVGIKSQELADYQTLRKVIGVASSNANKEMADLRAKMKAIMSSVERLQAQEKILKAKVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTY5</accession>
    <name>A0A6A7BTY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_265866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTY5"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="296" mass="31759" checksum="0AB77AB4A8B32BF0" modified="2020-06-17" version="1">MGASAAVERRKIITLPSVQRMYERKERIVMLTAHDFPSAHVADQSGVDMILVGDSLAMVALGMEDTSELTLDDMVLHAKSVARGAKGAFTVGDLPMGSYEVTPEQALQSSIRMIKEGRMQAVKLEGGMEMESHIRKITTAGIPVLAHIGLTPQRKNALGGFRVQGKSVEGARKLLADALAVQTAGAFAVVLEAMPPEIAGYITNTLRIPTIGIGAGNSCSGQVLVQIDMSGNSPPGRKLAQFVHKFGDVWGEARKSIEAYKSAVKEGSYPAEKHTYPMSKETYTEFLESVTQTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU91</accession>
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        <submittedName>
            <fullName evidence="5">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">K470DRAFT_259952</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
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        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858275.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
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        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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    </dbReference>
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        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <end position="126"/>
        </location>
    </feature>
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        </location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
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            <begin position="277"/>
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        </location>
    </feature>
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            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="621" mass="69864" checksum="A1E43315311C12B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUA8</accession>
    <name>A0A6A7BUA8_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">DUF500 and SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">K470DRAFT_272242</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="443981at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="34779" checksum="D55E6F387A47E8FC" modified="2020-06-17" version="1">MPISINNPLPSSMSSETRKCAKILESFIDPKQAFGPDKVIPRHVLAQAKGFAILTVFKAGFLGSGRFGSGVVVARLSDGTWSAPSAIGTVGGGFGGQVGFELTDFVFVLNNDMAVKTFAQAGSLTLGGNVAVAAGPVGRNAEVAGAASIRSVAGVFAYSKSKGLFAGVSLEGSVLVERRDANEKIYGQKFTARQLLEGSVRAPPQADALMQVLRSIGDSPRSIFDGVHELPSHANPSETFDRLERRRSTLSGDKRVPPARPLGPKPILERPRAVAKFTFDAEADGDLGFTKGEIITVIKQTELETDWWVGKIGEREGVFPSNYVQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK5</accession>
    <name>A0A6A7BUK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">transketolase</fullName>
            <ecNumber evidence="3">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUK5"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
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        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
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        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="323"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
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        <ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858409.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="621" mass="68455" checksum="E13C4C4D443668BE" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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        <source>
            <dbReference type="EMBL" id="KAF2858863.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025668389" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="59" mass="6531" checksum="8794F428C16230B7" modified="2020-06-17" version="1">MHLRILAVLFSVTDTVYDTPGINNLSRPNVMVALDASYARELGVAILPTAFRRTLEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVX2</accession>
    <name>A0A6A7BVX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_219767</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVX2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2859127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="505" mass="57695" checksum="4C6677B9168E2CAC" modified="2020-06-17" version="1">MFLALFASPWAWALLPVLILLLPYIRNWQIRDIPGPFLAKLTNLWYMYECRRCRRYQTVYDLHQKHGKFVRVQPNQISVADADAIPIIYGHGNGFLKSDYYDAFVSIQRGLFNTRDRIEHTRKRKIVSHTFSAKSVGQFEQYIHHNLEKLVAQWDSKSAEAKGDFYRFDALHWFNYVAFDVIGDLAFGAPFGMLERGEDFAEVQMSPDAVPTRARAIEVLNRRGEVSNVIGCLPQIKPFAKYIPDPFFYRGVEAVENLAGIAIARVKQRLDAAERGEINRVDLLARLMEGKDAEGKPLGRQELTAEALTQLIAGSDTTSNTSCALLFHCLMNPRVVEKLQAELDETLPSDNVPSYDQIRNLPYLDMVIRETLRIHSTSAIGLPRVVPPGPGVDIAGRHFPQGVVLSVPAYTVHHSKEIWGKDADKFRPERWEKLTEKQKLGFIPFSYGPRACVGRNIAEMELALIVATVFRRYEFELYQDVLETREGFLRKPLGLEVGMRRRNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW19</accession>
    <name>A0A6A7BW19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_95959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW19"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="20390" checksum="09611E6196868B27" modified="2020-06-17" version="1">MGDHTRSCRNICESHGNPSKDDLRSLTPRIKSFDSPLEPDELRSEAINHGIALHPCPNSHKMVGGGLHLEVVVALVPSVQELMLNWETPAPYFVTKARARCGFVMNFTNPGARRSAFSATRLTSDSGKALRIVCSGTHRIVSSATSGKPFKVLLMRKDGARFGRWTHAVYCTYDTSISVDFTATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWA6</accession>
    <name>A0A6A7BWA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_219227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWA6"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWN4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="90" mass="9657" checksum="32B7DC9A3FB2BF27" modified="2020-06-17" version="1">MDSKSTSFEVSAEGGTTFSGRSQDLPAFLMHVRLKELLDSDLREQAIKCAYVALQLRSRAQDWFSSHGTGPSGPSKTAQSSGLGWSTTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWN7</accession>
    <name>A0A6A7BWN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_109991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWN7"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="8014" checksum="BBD0C08834FFEA91" modified="2020-06-17" version="1">MSTQAQLPAQPVKLSASAENGEKVKPCCVCKEEKNSRDECMLFSRAADPQEECKPLVDKYRACMKGYGFEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWQ6</accession>
    <name>A0A6A7BWQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_94772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWQ6"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025375022" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="237" mass="25367" checksum="D096E2A28777F800" modified="2020-06-17" version="1">MLAPLAAMLFLATLVASAQTSIANGAHLTILPLGASIVWGYESSDNNGFRLKLRELLENNGNQVTYIGSQHNGGMTNNACEAYPGKTIEEVTASPLGTGVFDDNPNVVLIHLGTNNCVQNKATSDSANHYGDLLNDIKKHAPNAVVVASTLIPNGNANIESCIKDLNNRLSNVVANARSNGQKITLVDMHAVVPLSQLNADKTHPTDTGYQMMAQSWYSTLLGTSNMLEKKARHWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX20</accession>
    <name>A0A6A7BX20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PC4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_271335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX20"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
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        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="457" mass="50486" checksum="82799CEACB982D3B" modified="2020-06-17" version="1">MTDHLAQRLGDAANNGSHAQVHVPSHSISKGSTGLYPLNTALSTPVSSSILSPTSSARRNAPEPNKRVLYVGGLDPRVTEDVLKQIFETTGPVQSVKIIPDKNFQTKGYSYGFVEYDDPQCAERAMQTLNGRRVHQQEIRVNWAYQATNKAKEDTSNHFHIFVGDLSNEVSDEVLLQAFLPYGTVSEARVMWDMKTGRSRGYAFVSFRERADAERALSEMDGEWLGSRAIRCNWANQKGQPSFTQQQQQHQAIAQMAMGPISPFGQGPHMLPPRTQSYEMVLQQAPQWQTTCYVGNLTPYTTQNDLVPLFQNYGYVIESRFQADRGFAFIKMDTHENAATAICNLHGYNINGRPLKCSWGKDRDGYAPVPTTAAFAPPTAAFFPQYGQPSPMSPQGATGPGALHYPQHHASGSWAPQQLPSHPMHSATASWAGPQQSGATYPMQPQSAGPYTRYPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYL5</accession>
    <name>A0A6A7BYL5_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="51" mass="5969" checksum="076431BE8BBF8AD2" modified="2020-06-17" version="1" fragment="single">MNVLFEVSRSQCTLFQACARLGRCVVWWVEFVTSLTVLNRPNITYNCRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYR0</accession>
    <name>A0A6A7BYR0_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYR0"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="19578" checksum="11B4A0153D0611AE" modified="2020-06-17" version="1">MNDEAESQVSDVLSSPAKMSLLWTQHEAELQRTMDLLGQTKQLIQEIETEMTQTPTTAVVRQGLPLYTLGTTRQRVAEVAAVMTQLDPLFSKTHRQISNFQADNDVTSNGASQAFSHWQERVEKMTSREREHELRELRLQDDAESKRLKQDLELVSRSIRARARESSGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS3</accession>
    <name>A0A6A7BYS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_67227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="193" mass="21447" checksum="0AA39168D6ACEBEC" modified="2020-06-17" version="1">MLFEYFAIQGFSLCSLLSGRGTAPILLNNKRKLPLHHLARTLIVLVCGPLLSLQSFPARYRILHLSTTHTCIGRFDCTLKGLLLIFSRFGLHILSILTIRRTVFDTLMDDSFHSLNVFGIHSRNVFAVSMPETIFVCATSAAIPATSGAVFFGGQHPDSLQPLSWSALLPSTVFPLLRSLQIVRDLYEFHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ41</accession>
    <name>A0A6A7BZ41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_247408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ41"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="36802" checksum="5ED8B7BDA35C0BBB" modified="2020-06-17" version="1">MGYKAGMTTIVRDLDRPGAKLHKKEIVEACTVIETPPMMVVGMVGYIETPRGLRSLTTVWAAHLSDEVKRRFYKNWYKSKKKAFTKYAKKHADESGKNIARDIERIKKYCTVVRVLAHTQISKTPLKQKKAHLMEIQVNGGSVADKQNEMIDCIAVTKGHGFQGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQMGYHHRTSVNHKIYRIGKGSDEANASTEIDVSKKKITPMGGFVRYGIVNNDFVMVKGSIPGVKKRVITLRKSMFTHTARRALEQVDLKWIDTSSKFGHGAYQTPAEKKQVMGTMKKDLVVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0V4</accession>
    <name>A0A6A7C0V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_201725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0V4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13674" checksum="A19B18896D61C84E" modified="2020-06-17" version="1" fragment="single">DALRWVPANRNLMNETPLQTYLSALAFAPSNSIVRNSFRSETEVWPPAATDWGFELQTLRGHIDVILSITPSSDWRRLVTVSYDNTVRLWDGAGRVLKGHNSPVWCLHFSSDSETLVSGSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0X1</accession>
    <name>A0A6A7C0X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_215915</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0X1"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2861043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19230" checksum="D0A9E522ADBE0919" modified="2020-06-17" version="1">MSTQSQSVSVSTILLSAGAAIAVGGIAYAAYFDYKRRNDPAFRKHLKRQHQKVAKAHEMESKSAEREHKKKIEQIVADARSGALPTEMEEMESYFMNQVAEAERKCSDGSDILDAAASFYRALKVYPQPRELISIYDKTVPKPILDALAEMIALDPSISVSGPSSATGSDSGTGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0X4</accession>
    <name>A0A6A7C0X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_257423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0X4"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="41125" checksum="EB1D4B4BE6443E3A" modified="2020-06-17" version="1">MDAYDYENELQVSIRNATPTMIEFVLRNTSLAMANSLRRVMLSEVPTIAIDLVEIETNTSVLADEFLAHRLGMIPLVSREMDQMAYTRDCNCDELCDNCAVILRLHAANRSSDQNVKVYAKDLFTETISGNTLQRPGIGHEDELPPRGMPVITDPSGNGALICQLRRGQELRLRCIAKKGIGKEHAKWVPTAAIGFEYDPHNKLRHTTLWHEGPNPKEEWPVSSNAEWEEAPQEMDKFNYDAEPKQFFINLEGTGVMPPEQIMNDTVYTLQHKVTRIVRDLLNMTDMGHEIREVPKEAMNPDGGITDAHVQNTNYGTAYGGTTPAFVQTTAYGQNTAYGHTPGYGSTTPAYGNTTTYGGLGGATPYGRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Y1</accession>
    <name>A0A6A7C0Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Y1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="88" mass="9599" checksum="9C61EE3469028BCA" modified="2020-06-17" version="1">MRPLTTSQRVPFRGRPAGGFRKANITDDLLRPALATTDGAGSGSRTALATKNAWQGVSTNQYTRRMKRGSCSDRQWTFSLGGIERSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C173</accession>
    <name>A0A6A7C173_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_281797</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
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    </dbReference>
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    </dbReference>
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            <end position="1362"/>
        </location>
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            <end position="1465"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1501" mass="170863" checksum="AD30169DC65480C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1A4</accession>
    <name>A0A6A7C1A4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_269972</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="523" mass="58010" checksum="434FC750A0E7E465" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1B0</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_256959</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
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    <dbReference type="InterPro" id="IPR008984">
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    </dbReference>
    <dbReference type="Pfam" id="PF00498">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2861291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="48658" checksum="D24BCF0DE064121F" modified="2020-06-17" version="1">MQDGLAQVTLTELDTLKPPNHFLMCAGRKISLGRDTADAEADFSCSNRVVSRTHACIKCRTSSNFVIEDLDSLHGTQLNNQHLSPSRQYELADGDVITLGHNLPRGSVTHFPSRVQFNAAEPSSATLEAYKLKEHPFKYWSDIEFTDDDTSTPLPNHSQRNPMEIQAPHSHFTHGNKQCLHWNEGEGDNENGDGSDQPEEDSLAEQSDSEDMDDSNTVGLVKEDLDTEETNSVNSTYSPSTTQDDREFQLEYAIPDPDVNDEPTTFSDKCYELSPRWEMLDERSLYANSNMGRSQPPAEDKPRASRISISNLVAKSSSPASTEINTSELCFGEKDNDQVVEEHHPSDNRNFKRKAEKISGESELEEAQQTGTIVPPQELEMSTVLPAKKLKITRAAGCNSRCATRKTTVVGASAVLGSFGMFAFLVSPLAQAIIEWAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1I1</accession>
    <name>A0A6A7C1I1_9PEZI</name>
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        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_257235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Csc1-like"/>
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    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="204"/>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="808" mass="90886" checksum="50EA1E26CBC78982" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C1Q4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="17047" checksum="2311B1E28EA5A5F3" modified="2020-06-17" version="1">MRCLVQALGIPSLGYVPKMTVRHRIVLPCGVCFMLSRRHRMSSFSGGGLVRLFFFLLFFFLHFTSMSLLGARWRVKPRGQGISYLTNPTYPFMSLISFVFLRVTAGHLVLTWQLALWAHRVEEVGVLEEQLEGLSSVCGRKDPQNVQTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861079.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="660" mass="73820" checksum="0C25F27CD143EEF8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C240</accession>
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    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C240"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025662906" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8295" checksum="46EE38BD0012BE55" modified="2020-06-17" version="1">MLIVAVFFAIHIVQPHLTGIFKSYTDGEGRSGSRLRRGAATCPAMKSSMSSIRGTPSVGAPQKDCHAYEFPRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C7</accession>
    <name>A0A6A7C2C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_33296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2C7"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="361"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="554" mass="61463" checksum="1DE0222E0D78C774" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2J6</accession>
    <name>A0A6A7C2J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2J6"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="148" mass="16113" checksum="0B35E06BF5E920B4" modified="2020-06-17" version="1">MTSNQSSIKTTNLAKNPNASLLVHDWVSSRPPGDRDRSPEGRRHSSLATMLMQMNSAAVSSISVTINGGATVLEPGTDEDKWCREQHLLNNDFDDAGEAMLGTSPTTARVNGSRESYLANRDVRVVVVKINDGRISDWKGQIKDFAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2K1</accession>
    <name>A0A6A7C2K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_214416</name>
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    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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            <begin position="1"/>
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            <begin position="222"/>
            <end position="241"/>
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    </feature>
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        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="30423" checksum="F753E38ADB52620A" modified="2020-06-17" version="1">MESGGIPSLTTSPTMSFQREASPTSQIRSWQVRWEENKTPWDRNAPNPALADTLNEYSSLFGGPTQPGIQARKKALVPGCGRGYDVMLLASYGYDAYGLDIAPQAIQEANTVLQAANFESKYPVHGPGRGEMKFIQGNFFSDDFLAETGTKTFDIIYDYTFLCALPKEWRPRWAKRYSELLAPKGYLVCLEFPLYKGANEPGPPFGLSPQLYEQALGRPGKGIEYDDEGDGSARPFEGERSKDGLIRVARWKAKRTHEVGKGSDHVSIWTHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3L8</accession>
    <name>A0A6A7C3L8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_204217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8048" checksum="87DB7E191D041BBD" modified="2020-06-17" version="1" fragment="single">LVGFYVTNHALSAKERARPSNVIPITPGPHGTNTSEVIDAIGPEMEQLDAGIEVNMAGQKYVLCVMIYCCIGDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3P4</accession>
    <name>A0A6A7C3P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">K470DRAFT_257004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="339" mass="38107" checksum="636A35B3A9ED996F" modified="2020-06-17" version="1">MRPILLSGHERALTQVKFSKEGDFIFSVSKDPTPCAWYSHNGERFGTYKGHQGALWTVDVDPTTTLLVTGGADNTMRLWEIKAGRQLKQWEFPTSIRRAEFSEDGKLLLGVTEKRTGHLSNIYVYDIVPDVEAEQASEPTLRIEVTDLPRVTVAGFSCLNDYIITGHENGCVAQWDARTGELLKETYPHEDGAVVTDLQWSTDRTYFITASKDKTAKLIDSKTLDVLKTYVADTPLNSAAITPTPDFVILGGGQAAMDVTTTSARQGKFEARFYHKIFEEEIGRVRGHFGPLNYVAVSPDGKCYCSGSEDGYVRVHHFDPPYFDFKYEVEREREQDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3W1</accession>
    <name>A0A6A7C3W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="632" mass="70604" checksum="4EBBA5C2465865B6" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Q2</accession>
    <name>A0A6A7C4Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Q2"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="290" mass="31517" checksum="1B34A4A78E79806D" modified="2020-06-17" version="1">MTDPFEVRMRFTSLLIHLNASSSSAIKAAQYALRHVEYADDLFSCILEQLENPANSVNNRANIMFFLPRLCEAARDRRPGGGTPVKGATATTAAASAGAAKGEEYVTMVDSEIARIVDAVAPPAISDTGGGSANVRVVRQVLTQLGEKGHVDHAKVGELLEVMSKRDLQHGDGGSPGDRAVEAEGEAAGDKIAAAVATAPATVVDTSVPVKKASVLDRRQIEQRIEEDRERHKRARESIWMMPQAPGSGLREDAEFDVLWKHLKPADEDDYLMAREEKEMRLLGLEYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5E9</accession>
    <name>A0A6A7C5E9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_164866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5E9"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="25513" checksum="AAADB5424DE534E6" modified="2020-06-17" version="1">MVYYFRSTAVMPAAFIYVGKDKVENEELIAHGWDEDVWFHVDNLSSAHVYLRLRVDEGETWDSIPKDLLTDCVQLTKANSIEGNKKDNVNVIYTPWSNLKKTGDMVTGQVGFKNDRLVKKVLVSKRENAIVNRLNKTKVEKFPNLRQEKEDRDRELRKRERIMAETKKKEDQRIVEERSRLKWQKEHMYDELHTEENMAESSNQDRDPDFLDEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5L9</accession>
    <name>A0A6A7C5L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_243119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5L9"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="213" mass="24316" checksum="04085626FCF4AC9A" modified="2020-06-17" version="1">MAIKHNQQLPNNHFHKDWQRRVRVHFDQPGRKQRRRNARKEKAAKLAPRPVDKLRPVVHCPTIKYNFRVRAGRGFSLAELKAAGISRKFAPTIGIAVDPRRQNLSEESLKANVERLKAYQKKLVLFPRNPQKPKKGDASAEEVKAARENGVVSTQKTFPTVQKAVVREEKISGQASEKAAYRKLRDARSEARYVGQREKRAKAKAEEAAAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C625</accession>
    <name>A0A6A7C625_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_268504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C625"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="280" mass="31169" checksum="AB88D0C4BDBA4CBE" modified="2020-06-17" version="1">MSCAALRNGCRLAIRLHARPFSTSGRCPVNLNDRCNDTAELYRKFQLEKPLNPHITNTTSTITNEMPSVGAGSAPAELLTNADPKFTPVDSDPANTKHMTGGTQDSGKKEYDVGELEGGSFRVEPLRRTGEDMETMRARLLYQCRKRGTLESDLLLSTFADAQLTSMSREMLEQFDRFLDENDWDIYYWATQQPSPTAVEAAEGTVSSKDEHVRHHSGEWAQTVGTFKAAFRPVPSRWRDSELLSMLRKHVVDRSSKGAQFGASDNSGKGMGFMPRLNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C668</accession>
    <name>A0A6A7C668_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_293280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C668"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="420"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="609"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119495" checksum="05270F7BE232DD5A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6J0</accession>
    <name>A0A6A7C6J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_155067</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6J0"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="235"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="331" mass="36123" checksum="067825C1CB46E656" modified="2020-06-17" version="1">MSSANQQTPLSRADVREDVPLSAVYRFRGWVSQVVVASFIAGGVAGAVSRTVVSPLERLKILFQVQSTGHTEYKMSIGKALKKIWREEGFKGMMAGNGTNCIRIVPYSAVQFGSYNIYKPAFERTPGEPLSPTRRLLCGACAGITSVTFTYPLDIVRTRLSIQTASFASLSKAEARAMPGMWATMAHMYKTEGGFLALYRGIVPTVAGVAPYVGLNFMIYESVRQFFTADGQANPGPLGKLCAGAISGGIAQTCTYPLDVLRRRFQINTMSGMGYQYRGIWDAVSVIVRNEGFKGLYKGIAPNLLKVAPSMASSWLAFEMTRDFLVRQKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6M9</accession>
    <name>A0A6A7C6M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIP120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1313" mass="143586" checksum="90F91A5514CD59A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6S2</accession>
    <name>A0A6A7C6S2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_211268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6S2"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30384" checksum="C20F5DE7AE070229" modified="2020-06-17" version="1">MSQVKFEQRDEYITQDGPGPRPRPSRAPQPPQFQFPQPPQPRQKEDLMHEAGNALTKGADGYLAWYLEKLRESPLRTKMVTSGSLAALQEFLASWIAKDRNKHGHYFTSRVPKMAIYGAFISAPLGHIMISILQRMFAGKKTLRAKIMQIVVSNLIISPIQNIVYLTSMAIIAGARTFHQVRATVRAGFMPVMRVSWITSPIALAFAQAFLPEETWVPFFNFVGFVIGTYVNAHTKKKRLQALRRKYQDRVERSEYERRSGGPPGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7H2</accession>
    <name>A0A6A7C7H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_280447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7H2"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025597917" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="434"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="552" mass="58919" checksum="877ECC9A94D6322F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7N2</accession>
    <name>A0A6A7C7N2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_254880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7N2"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="371" mass="41959" checksum="2512EC31ECF059F6" modified="2020-06-17" version="1">MPKARKISKGVTKSDPYAGAAARKSAGQKIGHNVFKMNTDLGQHMLKNPGVAQAIVDKADIKQSDIVFEVGPGTGNLTIKILEKAKRVIAAEHDPRMAAELTKRVQGTPSAKKLEMVLGDVIKLDPLPYFDVCISNTPYQISSPLIFKLLATSPSPRMCVLMFQREFAMRLIARPGDKLYSRLSVNCQMWAKVEHILKVGRKNFNPPPQVDSSVVRVTPKRPRPNISYEEWDGLLRVAFVRKNRVFRSAFLGTTSVMDMLEANYRTYCAQHDIAMEDGPADVEVEMDDVQDDEMDLDLDNDDQDEPDFFQPKANNEPTKRKIKSKVAELVRRKVQKVLEETQLAEKRARMCDVADFLKLLYAFNKENMHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7W7</accession>
    <name>A0A6A7C7W7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_210349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="47"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863503.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="306" mass="34827" checksum="278AE5707471A7F5" modified="2020-06-17" version="1">MPLHHSAQTGFAASKNYDLYRPSYSHTVVQYVLDKAGVAGRQHAAILDLAAGTGKFTELLARREEGYDIVAVEPHDQMREVLTEKGLKGVKILKGAAEDIPLEDESMDAVIVAQVGHSVCSWAFHWFATEDSLKELKRVLKPRGMLVLVWNIEDYNAARDHNAATPWESRVHQLTWSFDDNESRFRHEKWRQVFDDQLESSPLALVKGGKDVYFSLPLGEHVEPFETWMDKDRVWDRYSTLSHISVLQGERREKTRREVMDALQDAKKNIKGEVAVHGNTYIVWTSKVPQEGKKNVFSVEDPAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Y4</accession>
    <name>A0A6A7C7Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7Y4"/>
    <dbReference type="OrthoDB" id="5427804at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="168" mass="19088" checksum="9D937BB4D820C629" modified="2020-06-17" version="1">MNAAGCMSSLQPLDMSVNEPIKRLVRNSLDEQQKAYEETHKYCSDDRRIMVEHTMLELQKEHGRDIIRQPFKCTSISVTPTGEEDDKVHIKVVSNYSFANRQQGGNVDHNGEEQALADPRALDSSWMGLEDLRLRLQSYKKDQLKFHICSGSKTNAPTVTALVFPYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C5</accession>
    <name>A0A6A7C8C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8C5"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="417" mass="46259" checksum="2B646954474C5B12" modified="2020-06-17" version="1">MPLQEEQNIAALQDTSLNLQNIIAITSSDAINNTHEIHYMLNDKYHRESVPTSNIPPALLKNLSLPTSLWFSTKPQRIHVIVSTHSGTGKGREVYSSAVQPFLASLLPDADIDVSETQSAESVSIIVREVILPAANRGEEQLIILLSGDGGVVDVLCALREGERNTFYVKPVLGLLPVGTGNALANSTGLTRDDTFDLRALVHGGPRSLPHFVVRFQEGGARKDGEVVAKMYGAVVFSWGLHATIVAESDSPENRKRGVERFQIATKDELFPLGGGPPHAYKAKEVSILRQPDGEWQVMERQTHGYVLVTLVSQLEKGFTISPASRPMDGMLWLVHFDALDGNETMRLMMRAYDNGNHIEDERVGYEQIHGLRIEFGNDEDARWRRVCVDGKIVQIEEHGWVEVVMDKEDVIDLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8D7</accession>
    <name>A0A6A7C8D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_240942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8D7"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="28169" checksum="6CEA970CFD5037FC" modified="2020-06-17" version="1">MAPLYTDDTPKDVKDAKGLHLITMNTPNGQAVQIMLEELKAVYGTEFTTTVINIMTNEQKKDWFLRLDPNGRIPVLVDNTTRPPFPVMETSAEMLYLLKKYDQKDEFGFKDDLERSQALQWTFFWHGSGAPYQGQVYHFRNVSPEKIPYAIDRFANETLRVFGVLEIQLSGKYADGPRDYLAGNGKGKYSVADMKTWPWVRGWERMGFTREQMDKFPNLLKWIDRIAQRPAVQKGIGEAYALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8H1</accession>
    <name>A0A6A7C8H1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_254633</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="459"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="769"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1246"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2863740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1449" mass="162862" checksum="4BDCAF3E7FFFB25F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9C1</accession>
    <name>A0A6A7C9C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9C1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="398"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="475" mass="51048" checksum="777131E46E0C045B" modified="2020-06-17" version="1">MGQTLSEPVVEKTSDSGQDDRVIFGVSAMQGWRISMEDAHAAVLDLQPLQPGSEQTPAASDVRISFFGVYDGHGGDKVAKYAGNNLHNIIAKQPAFQKREFEQALKDGFLAIDRAILSDPKYEDEVSGCTASVGIVTNTHIYVGNAGDSRTVLGIKGRAKPLSLDHKPQSEAERARICAAGGYVEFGRVNGNLALSRAIGDFEFKKSADLPPEQQIVTVFPDVTQHELSDDDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQELQAICENMMDNCLASNSDTGGVGCDNMTMIIIGLLNGKTKDEWYKMVADRVADGDGPCAPPEYAEFRGPGVHHRSDNSEDYSADMEQRTRVFGSLLGGLGGRVILLGDGSSSESSNVHDDDGDVDMEDHNITEELEDKDLDAQVKKGQENNGTVDGNARKNSEESTETSNGSVKQLPQAVRPSSPLSSTKPDSSTTTGEAKAQLQNSKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I0</accession>
    <name>A0A6A7C9I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ER-golgi SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_226274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I0"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="311" mass="34926" checksum="BFF1929A222AAE9D" modified="2020-06-17" version="1">MAHSVQDRTPEFRSILAEAQRQIARQRKQPAPAPQTRKQRSEFARNAAAIGRGISSTVSKLERLGELARRKTLFDDRPVEINELTYVIKQDLAGLNEKIGQLRSGQREKGEEAEHKQNVVVLLQKNLADVSVNFKEVLEVRTRNIQATRSRQDNFVSAVSSQTPLGTPRTDSPLYQMPPRKPEQDTLSLEPSSGGGALYQHGGGMTQNEQLSLMEEGSSSYVQQRGEAIEAIERTINELGGIFGQLAQMVSEQAEQIQRIDANTDSVVDNIDGAQRELIKYWHRVQGNRWLVAKMFGILMIFFLLWVMVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9S0</accession>
    <name>A0A6A7C9S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9S0"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="397" mass="44099" checksum="E601494505841AD2" modified="2020-06-17" version="1">MPYNTRRKSLSLVELGVVAPPKRSRAESQPSHAIGPDQEPHLKRAKRSHGDRPSQYLMSIRVKSEKQQTAGAELSPPLSPLAMTSHTVDIDGINDDIVVAVIRQLELRANRPLLVRQLAQVLATNIPAVAKSTNPSALIASRLTSYINRPWPAMSPCPLAKDLSLVHPRRLYFYLTTLPRQPLPVDAEPLCKPSTISPSLSSSSGVEDESSEGRRSREVMSPSPEIELCTPQLDDDNEEDISAPPTAYFSARSSVNSLSRSSSMSHHRVGSPPLEREEHDFRQTANKCHERAQLARNLRRLEPDIALVDGTEPFLPPAEPDDMYKHDFDATLFGQPESHRPMLPLSMSNPCSPILVPQSTFSPCRGNRGSQLPKDLFNLESPENIEVEDLETMFDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9T7</accession>
    <name>A0A6A7C9T7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9T7"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="281" mass="31208" checksum="5AA73E4C16DF3708" modified="2020-06-17" version="1" fragment="single">MAKDTKKKKAEKKARTALKTAKKAHQKTKKQRRASISSTESEDIDTILASFQTTTTTTPTPREVKCPPPRARSATTLLPSPTSKELILFGGEFFSGERASFSNELFIYKVASRQWRRVEGDGPLPRSGHAVALLPSKGEYYLFGGEFSSSRQKAFYHYGDLWRLTARGGWAWERIGNSTAKGGAGPSARSGHRMVAYKQFVFLFGGFQDTANETKYLDDTWVFDTSTEKWWSVATQGLKPAARSSFSFLPHPEGAVLVGGYSRVKETLRGGRTTTRPLVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA18</accession>
    <name>A0A6A7CA18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_3472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA18"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025719490" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="651" mass="69548" checksum="94CB2A9CD96A6B2B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA36</accession>
    <name>A0A6A7CA36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">K470DRAFT_208375</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
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                <person name="Bloem J."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAF0"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="87941" checksum="1D0EBB3A41DF5D21" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK7</accession>
    <name>A0A6A7CAK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_226256</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAK7"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SURP motif" evidence="16">
        <location>
            <begin position="463"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2863648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112773" checksum="5F2EE448A580E39E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAQ6</accession>
    <name>A0A6A7CAQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_267645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAQ6"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="37134" checksum="1F08EDC6B4D56997" modified="2020-06-17" version="1">MNETHGEDVASKVLRRVQVSKIARTLQDRLALANVKMQNGWENMSLEAIEPQIKRKRPNSSNEASDTASTVSSRFNSSSGIDSSPLTGPMYSDDFVRSCSSPSKRRRLRPAASLPSFDTALGRSTRWTRRQTLVQSSPLSRDRQITMPPASILSFISEAPTAPGSSPSPSESEDDDSDLPLHSFSLANSISSPPRTPSPDRRLRKSQSQSIPWSRTPRGDGDWFTCQTSTPGDDDTERPTRITAQPPSTPPCKPTPLPSSHMTPGTTGAGFLALAPATPGGQVNFAEFVNITPSPAQVPWTRTPTTFRTPARRRLNFDNIIPPPRTCRGTGLGLDLGGELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNV7</accession>
    <name>A0A6A7BNV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_224074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="MU006084">
        <property type="protein sequence ID" value="KAF2857044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNV7"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="37858" checksum="A409B26134980016" modified="2020-06-17" version="1">MHSKVVIIGSGPAGHTAAIYAARADLKPVMYEGFLALGIAAGGQLTTTDEVENFPGFMMIKGGELMDQMRAQSKACGTEIVSQTVGKVDLSQRPFRYWLHEMGEEVELEEEVHTADSIIIATGAKARRLELPGEDQYWGKGVSACAVCDGSLPIFREKPLVVVGGGDSAVEEATYLTKKASKVTVLVRRDVMRASKANIRRLSNNPKVEIKYNTSPVEIKGGDGPRGLMTSLMIKDNKTGQMEEVEANGLFYAVGHEPATHLFKGQLNMDEDGYLITTPGTTETNIPGVFAAGDVQDKKYRQAVTSAGSGCMAALEAEKWLAEQEDVDVPGTTEAKKGDDNAPEYKQNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPC7</accession>
    <name>A0A6A7BPC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006073">
        <property type="protein sequence ID" value="KAF2857072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPC7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="22730" checksum="8002BCA9BA0922B1" modified="2020-06-17" version="1">MSERISHNRMLFPGIDNYRLNPHFPALLSSIPFSHQSLSHILSNSHQRQWHPCPPYRPGLNRARFLKSTITLYIATLLSALVAVLLISRDLPEVENTSLPPNPPTSTSGISCFGSLTAHAEQQCKQGLKPRRAASQYACAHPRSTRAPPQVIIKTKTFLVRVVVFISEVVKEEGTYRGEERFTRKSVQRLGETLSYVLAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPG6</accession>
    <name>A0A6A7BPG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPG6"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18623" checksum="E5868505275763E8" modified="2020-06-17" version="1">MAETQAQPFVFDLGHLMVTDPNPLTSSTESDLEASARQCAQGIINKLLTSCPIERAGDGELSIKLPDPVTQLPREKPIPKPKEKTKWERFAEKKGIKPKRKSGKLVYSEEKKDWVPKYGYKGKDDGQADWLVEVDEKAERKQESEEIQNGNGKQTTKRKKQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPV8</accession>
    <name>A0A6A7BPV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane domain transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_261044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006059">
        <property type="protein sequence ID" value="KAF2857202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPV8"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="293"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="694" mass="75637" checksum="77DC2FEDB32F7902" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ00</accession>
    <name>A0A6A7BQ00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS phospholipid transporter Git1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006046">
        <property type="protein sequence ID" value="KAF2857391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ00"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="481" mass="52327" checksum="9ED367BFBB6C7123" modified="2020-06-17" version="1">MTEKSPATDDATPHVSDRQPNRWAQVWPVIACGAGLFSDGYLNSVIGSVSTMLSVIYPKEYKHSSAISNVSSITFVGTVLGQLIFGWTSDHWSRKWTLVISTVILILFSILTTASYGAGGSVHGLLAALTAYRFFLGIGIGGEYPAGSVACAESTGSLRSGTRNRWFCLFTNVQIDLGFVVGAIVPMIVVLATTQSHLRAAWRICLGLGVIPPTVLLLMRARLQEPESYRQNTMAKTKTPWGLVIKFYWKRLMIVSAIWFIYDFSAYSFGLLSSQLLTNLLGDEKALWKSFGWNTLLNLFYMPGCLIGAWTSDWFGPKHALGYIVLVQAIIGFIMAGTYSYLAQPHYVGAFVVVYGIFIAIGEAGPGNNIGLIASKTCATAVRGQYYGIAAATGKIGAFVGSKVLILMYNDYYNSGEKVKAGQYPFLISASLCVVSAALALGLLPHIGQDTIVEEDKGFRDYLSRNGYDISKMGLEQEKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ36</accession>
    <name>A0A6A7BQ36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="635" mass="71586" checksum="8B563BB47DBEE16C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQY8</accession>
    <name>A0A6A7BQY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_279230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQY8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21308" checksum="2855082A203E76C1" modified="2020-06-17" version="1">MKNAISRFDCTSFFLDPCQHFKACNGKFEQLFEQRKSRSSVCLFLKLLERVRVLPYNSDKDFLCNHVATENLVENLTWNGAKGMEAVPQGNVNPLGTSLTSTSMSHHIRFSWIIRAMLAQLMGVDLASIEKAAPYIRVGELPLLVGIILVVIAKAVVIVLICPARRTGVAYSRLEEISLDDLEPPSRGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR81</accession>
    <name>A0A6A7BR81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR81"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="97" mass="10506" checksum="3FC960C72D206E76" modified="2020-06-17" version="1">MPTNDKRPSSSVPAITNLTDERRSYGCPSEKTLSEDMLVACTARMSLSIVVEIYVALLSSTTSTLPFSGTGGKALCRSWKELPFSDCTPEMRADISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRG6</accession>
    <name>A0A6A7BRG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_297060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRG6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="16573" checksum="4FD98E9FFFA32197" modified="2020-06-17" version="1">MEITLPHATLPCAMIPPTDRMHSGGPPTPGGPAKGVPGGIPGAGLAADAGAGGPFRAGGNGIFEGGNGILAPPPPPPPGGIGGKLLGLKPGGNPLGGAGNLQTVSLDANKRLGSTYPGGKGGIPRPNGIGGMPIDGPPMKGGALPSIPGPIPGTIPGVIPISPMPGAYICVIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRQ3</accession>
    <name>A0A6A7BRQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_260809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006043">
        <property type="protein sequence ID" value="KAF2857435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRQ3"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="109" mass="12013" checksum="6100D16F10931D48" modified="2020-06-17" version="1">MCHCQNCKRRSGGLASYAFLIPKGDVQIKGTTHTEYADHDTLSGKPLRRSMCSACGSPVRIIEASQPETWCMQYGLFADNALPKPKLELFAKDACAWENKVGETVMETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRT8</accession>
    <name>A0A6A7BRT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="MU006045">
        <property type="protein sequence ID" value="KAF2857409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRT8"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="224"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="301"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="42503" checksum="D53B99B08F42FD19" modified="2020-06-17" version="1">MSQTYPRLHRICVIGSGNWGTTIAKVIAENTRENPTLFHPDVQMWVYEEQVTIPTTSRHYRPGTPPQKLTSLINNLHENVKYLPGIILPENVIANPDLISAAREASILIFNLPHQFLGSVYRTLRGKTLPYARGISCIKGVSVSEQGCELISEAIGKELGIYCGALSGANIASEIAEEKWSETTVAYAEPQGGEGLPKEYPPLSRENVKRLFHRPYFHVRVIADVAGASLGGALKNVVALAAGFVDGLGWGSNAVAAMIRVGLLEEVKFGKYFFEKEVKTETFTEESCGVADLITSCINGRNFRCARLAVQRGVELKEVERTELNGQSLQGLTTAVEVARFLRSVKKEKEFPLFMAVDKILAGKAEAKDLPALLEGDVNTLSGRGNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRW2</accession>
    <name>A0A6A7BRW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_266452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRW2"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="42713" checksum="B3B3D391E7B7148A" modified="2020-06-17" version="1">MKAHPANCKFFSKGGCKFGHHCMLRHVTADGKVVHNPNFLEICNQPYVYQHQHYQLNYEAVPAHPAYYLDSLERWATPPRSSSPPPPEPEDDTLAAAQHDSPEECNAKEVPRQVWSCLDAPLPDTWDETVPPRARHAMCSSMPPRCGEDEGLFASVKNAMALKSARSGSCPDGPRFYHRRVLDKASLLPSIPSCDSEEEDDENSGSGSDQDGDEDGDEDGNGDVDNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQDQDRNHGQVQGQGRSKRKRKDKGKRKRKGKHVKSLLYLPTDLMDAIDNAAMPYCARRSSRYAEVFARNGSLSRRTHSYTSAAYEEDTLLPAPKKESPNPQKRKNQASEFDSPESSSEIPFFAMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSN5</accession>
    <name>A0A6A7BSN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSN5"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="39064" checksum="67452B7B2C2FBB95" modified="2020-06-17" version="1">MPENPDSEWGSDVSIYLRSPVRLNCQSRTMSSSNQIKNVAVIGAGGNSGTYMTKELLKTGKHTVTAITRAGSDSKLPEGIHRVAKVDYANPSSLLEALTGQDALVITLGTFVPPETDKNIIEAAVKAKVRFILPNEWAPDTANEGLRKDVGAFAGKEPIRKKIEAEGKGVTSYIAVSTGFWFEWSLAIPAAFGFDFDKKAVTMFDDGETKINTSTWPQVGRAVAKLLSLPIQADGDPKACLDHYKNKQVYVSSFNISQKDMLAAAMRVTNTKKEDWKVSYESSKERYENGVNAMKEGDNMGFVRMMYTRVFYKDDSGNFEKTKGTINSVLGLPQENLDEATAEAIKRSQETQWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTB9</accession>
    <name>A0A6A7BTB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTB9"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="57" mass="6549" checksum="46AFBB504FDB1D61" modified="2020-06-17" version="1" fragment="single">RNLSSLRPGGQHPAANQGQEVEKIEQGEPDAEILKHERSRELELKVFELRDKLEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUC6</accession>
    <name>A0A6A7BUC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_220950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUC6"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVC9"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="17144" checksum="B40C68C187EE1A64" modified="2020-06-17" version="1" fragment="single">MEVRPSGRLVGGAYAPKRFLEEQYEVIGFISSGTYGRVYKARQRHQSKFYAIKKFKPDKEGSLQYTGISQSGVREISLCTELKHENVIHLVEILLERKCIFLVFEYAEHDLLQMIHHHTMISSPINAKVIKAIMFIIIVSRCVPAYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVD8</accession>
    <name>A0A6A7BVD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_219830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVD8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="43309" checksum="3CBDBEA8DD23C8BA" modified="2020-06-17" version="1" fragment="single">EPPNQFVPGDCHPTFLGDSLDSEQYKIVHKLGYGNFSSVWAARDRKYYFSPSEEKYVAVKIRRARVKIGEVGMLRDISDIKTDHPGRRHLHTSIQKSTEPMNASSKTCSELPLNSSREKVSTRNPACQGKLAKEVYRQVLLDVDGLHQLGIAHGNTRLGLDAQTLRKKQFIRKMGTPAIHEVVRLLDQPLDPGVPVYQILFNLTPVPPTPTLPNIKILGDSQAFHHANAPDTLDAGMDTQPAEVVLKQKLDHRVDYWNLGCMLCELMTGQRAFNSLGISNKQLLFSVMDMTRQEMPKRGESAWKSLQEHKVEDDGERKIHRRSGSLFDLVEEFMRHTRSIAMSPQWFIDTPHGNDSHGMTFLYGREDEKRLRGVCIWWNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVW5</accession>
    <name>A0A6A7BVW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_234641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVW5"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="444"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="813" mass="88662" checksum="10ED86111225CE6E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW40</accession>
    <name>A0A6A7BW40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin-related protein, ARP3 class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="48126" checksum="67A0B8AD130E3ED0" modified="2020-06-17" version="1">MASQTPAVVMDNGTGYSKLGFAGNDSPSFVFPTAIATKGPVGGGGTGSGRPAVASKPSFLTGGVGPTGHLSAKRGTEDLDFFIGDEALTASAGPGYGLHYPIRHGQIENWDLMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIFFESFNCAGLYIAVQAVLALAASWTSSKVQDRSLTGTVIDSGEGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSMLRDRGEPDSSLKTAERIKEEFCYVCPDIVKEFARYDREPERFQKYDVKYPNGKSATVDVGYERFLAPEIFFNPEIYSSDFLTPLPNIVDTVIQTSPIDVRRGLYKNVVLSGGSTLYKDFGRRLQRDIRHLVDARIKASEARAGNVAKSGGLEVQVITHRRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW95</accession>
    <name>A0A6A7BW95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW95"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="528" mass="59019" checksum="D29D8014641F3FBA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWK9</accession>
    <name>A0A6A7BWK9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_249112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6780543at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031428">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="300"/>
            <end position="418"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="489"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="548" mass="60551" checksum="69E6D075A231D0BD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWY4</accession>
    <name>A0A6A7BWY4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_107752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWY4"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="23256" checksum="24BE91A32BD4F443" modified="2020-06-17" version="1">MEEASTKRQASMSSYLSNLLTHTTSRYNHLRRILLSNEEDGDTEEDSHISRVLRAYYTEKSRPFPPWLGPDPTRSSTPNPSAASRITQAASNTSPGKKSYNSLSDLWDTPANSQAQSQPLSLRTGRRPPTSGGGGAGSLLAAPAPQARPLPSQRAGSYQTLRTQAPSPNLTVEPPSGTGTPTGGGTAQDRLKARLWGGNRSNSSVTLPQASSGNSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXL0</accession>
    <name>A0A6A7BXL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone H3 methyltransferase complex and RNA cleavage factor II complex, subunit SWD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_258299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0048188">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="37729" checksum="40C3BB8676E2DEE3" modified="2020-06-17" version="1">MPPTCKISDIVATFRPAKAFSPPSPSNTHISMDFDDTGEFLLLSRTDDTLQLYNTAAGAHAKELKSHKYGCALARFTHHAPSIIYASTKVDDGIRYLSMHDNSFIRYFRGHEDRVTCLAVNPSKDQFLSAARDNTVRIWDARSTTAIGLMAFDGLRLCAYDPSACVIAVAAPAAQLVVLYDLKNFDKPPFATFDLREIEKKCGNGNGGAWTGMEFANNGQTILVTTNGAGHYLIDAFNGDLRRYLRRPSGPNGLAAPVDPLPKELPSYCQADAALAPDGRFVIGGNGKKPGLLVWDTNAPAQDAVGGLLPTSELPCTTTAKVAVYNPRYNLLASADRDVMLWQPDADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXQ8</accession>
    <name>A0A6A7BXQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_264829</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXQ8"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Dihydroxyacetone kinase"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
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        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="384"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2859994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="586" mass="61495" checksum="37EDD2BC29FB4334" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY33</accession>
    <name>A0A6A7BY33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5396360at2759"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="510" mass="54560" checksum="511009C3AC5E5CF0" modified="2020-06-17" version="1">MGVSNDAVSTSRPSHPPSAENAAPQASFRVYNAPRPLSATPTDGDMAQHHPPSGDGLAAAITRLQSQVSYNTNIIDSQRSQIAEIEQTMHSLHAHVERLGRAINDIRAGMRSGVDHNVPPPEDLEVLASQITQATNKANEVDSLKMQVKLLTNRLRRFEDGAAVSTASPPTFAPRAQTPLNTHDVAQSAAPAQHPSLPPMRMPVMSPAQERGPINAVHSHMPHVPLPQGEQPHAGSRYRPVEPLTHPPAVTLWRSHEHSQPAIHPGPSTSAQLPRSTAVNASGWRPVNVRATSKRPSEDTPNDQPSSAPGSPKRTKLTAILPRSSHGTDSGASVTSDSPRMATEEIVKPASIAPRPGAAPPSAYRFMPPTAPADAGEWKQEGALANNGRTGGRPEEEPHNGSGLSRGRGQQNSGSGKKTRTKPTRNADGILIRKDGNPDMRSISSVNNLRKVSAKKEAERAELAKRNAQQQQQQQQLQEQSIEENGEEEGPNTRQSTPKDGASEASDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE7</accession>
    <name>A0A6A7BYE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_86688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE7"/>
    <dbReference type="OrthoDB" id="2403773at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025428181" description="Invertebrate defensins family profile domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="4">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="99" mass="10634" checksum="A0C74EF6230976F3" modified="2020-06-17" version="1">MQFTKIFALLPVLALLAGAAPVADVADVTDVDDGNLISEDLQAEVNNLLIKRDPEIVKRGFGCPLFRQQCNDHCISLKGGRTGGYCSGTFRLTCTCVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYJ3</accession>
    <name>A0A6A7BYJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_299857</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYJ3"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="205"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="409"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="555"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2860173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="678" mass="75332" checksum="1811364ED898A9F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYK1</accession>
    <name>A0A6A7BYK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_217473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYK1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="25460" checksum="951B320E59F21AF3" modified="2020-06-17" version="1" fragment="single">GLVIYPSILPPKIQTTLLNSLLHTHLSNPLHKTNLHTHHTLPYQENTSFFSLPCRTPIPPTSPAHAPITTETLLTKKLRWMTLGGQYNWTTKRYPSSPPPQFPEEIASLVEGVVPGVKAEAAICNLYSAGDTLALHRDVAEECNAALVSVSVGCEGLFVAGLEGGGDDGGAAVRLRSGDVVVMRDEARWAWHGVPKICAGTCPDTVAEWPGEGFGGYKGWLRGKRVNLNVRQMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM6</accession>
    <name>A0A6A7BYM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_299728</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM6"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="16995" checksum="65EA4CAA4F3CD34D" modified="2020-06-17" version="1">MSSLPYAADAESPLKPAELQVLRAQYEKEGEYATLQTRFNYAWGLIKSSTTAEQQEGVRLLTQIFHSSPDRRRECLYYLALGNYKLGNYAEARRYNDSLMEIEPANMQARSLKQLIEDKVAREGMMGMAIVGGLAAAAAVGVGMLVKGAQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX4</accession>
    <name>A0A6A7BYX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADPH oxidase regulator NoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_193768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYX4"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="168" mass="18963" checksum="5DA5EC541929A247" modified="2020-06-17" version="1" fragment="single">MSLRVEIETWVRALEAYDRGDFSASLDEFSQMDHTARIAFNIGVIYATLGSHDEAIGAYARAVGRDRYLAVAYFQAGVSQFLLGRFEAAHRSFSDALLHLRGNNYIDYDQLGLHFKLYACECLFNRGLCAVYLQQRDIGLKEITSARNCKVVKEHDVIDEAIRESAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ25</accession>
    <name>A0A6A7BZ25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_217995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ25"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33155" checksum="EA765B033E93A1A7" modified="2020-06-17" version="1">MAFQQYTPKPVTDIFTPDDTDINRRECRRIVPMRVLALGLGRTGTASLRTALKELGFDDCYHMMSASVENPPDCLMWSDALAAKYDKQGTFGREQWDQLFGHCQAICDWPCVAFAKELIEAYPEAKVILTTRDVNSWHASTMKTVHWRATEPELKLVSKFDWAAGMYQPMLSKFWTEFWEGDFEKNGKRRFEEYYNEIRSLVPAEKLLEYKMGEGWKPLCDFLEVPVPEGKKFPRTNDTDGFVERCRRRNRMQMLNVLFRATVVGGSFAAIVFGATFTIRRFFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ33</accession>
    <name>A0A6A7BZ33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_90201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ33"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="40600" checksum="CC334BAE308C79DE" modified="2020-06-17" version="1">MDFPWHIGVFDAHCHPTDTLSSLPNVPGMRCRALTVMATRAQDQDLVADAAQKFGLTASDVAAGSWSAEHKIVPAFGWHPWFSHEMFDENDFEGAIELSYEQRILHYQKVLVPSSDDRNFLLSLPAPKPFGDFLNRTKEHLSRHPLALVGEVGLDRSFRIPEAWLPSQVGDRNGSLTPGGREGRRLSPYRVNINHQRKVLLAQLRLAADLQRAVSVHGVAAHGIVYETIAETWKGFEVSKKRKPKDDENLNYPPRICMHSYSGQADTVKQYTASSVPCKVFFSFSTTINKWSEEGDGKVEAALKAVPDERVLVESDLHVAGEQMDECLEQAVRMICRVKGWELETGLVRLAQNWRQFVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG2</accession>
    <name>A0A6A7BZG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_70940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZG2"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40953" checksum="C169F6BA7CB246CE" modified="2020-06-17" version="1">MSDPSQATSLKQLLASLTTIKGDLSNITAPPFVLAPKSTTEFPRYWIAYPSLFVAPAKASSQEMRMVAVLKWFLASLKGQQYAGGESIKKPLNAFLGELFMGECGQGDALCRLVSEQVSHHPPITACYLWNAPHGVRAQGFAEQEITLTAGGVEVRQSGHAIVHLDRTGEDYTIPLPNVRVKGILTGSPYPELHGTYDLRCSNGLVAEISFSGKKGLLLSRGEKNHVHARVYRTNEEDKTLFIAEGSWSDHFEITDEAGNIVDRFSFAEEDEPFSTLPLEEQDPFESRKAWAGVISAIEKGDMQGVVNEKSKLENAQRKMRGVTGLGEKDWEPLFFTRVSASEAQGDWQFDLDRSLKLERPYRGELTPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZI6_9PEZI</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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            <begin position="357"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="398" mass="43238" checksum="F4A5219476EA6565" modified="2020-06-17" version="1">MPLNQTVTIVNQSGKVIKTSKHLVNVFKDAKLAYDEKKAEIKAFRRVDEIRRIEAAKSASQSNKRSTRGEGSHFRKHSHDAAASRRGSGSQRGSGTSRPVLERGYTETFTPDNASSVPSRPCGELTRRHTATIAAPATAVPKQTKEEVDMALAYGPFVPPPVGTTPHQNEVMLREKMSSLQVMLDELSCVSHSVTTTITNLQKDPESLAAVGLALAEISTLASKLAPGALMSLKSSFPAIVALLASPQFAIAVGAGVGITIVMLGGYKIVKKIRESKANAVEAFTSNTIEAPDEPEELQELDGIELWRRGIVLDPNMEGGSGEGEFITQKAAKTLVSEGVLTEKDLKKDKKKKKHKDEKSKKVHSESGKSHHSSRAKETSKIKERKKEEGGLIRRVFR</sequence>
</entry>
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            <fullName evidence="12">RING-type domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0016740">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860407.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="77234" checksum="0687BDD2BB75E759" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZM8_9PEZI</name>
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            <fullName evidence="4">Cylicin I</fullName>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27828" checksum="964222127FF9CB7F" modified="2020-06-17" version="1">MSLRVRILQSIPSGPSLRPRIAFPARRGPTSLVRRRFASSGGGHGHDSGPSSDMPWAVGAVVATIPACWYLWPSSDLINGTASHHDDGHAAASAKDKGGDKEDEGAEDEKEEGGDDDEKEDDQKEDKDGKSEKQDDKKDAKEGDKQDKKDDKDEKKEEKSDKKDDKPEKKDDKSEKKDGKPEKKDDKSDAKDDKDDKDDVNDAEQDEKEGKDPKNTKKNNPTSETAQQAIDTSKPDSKAKSSGQKTGANPQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZW9_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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    </evidence>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the DCP1 family.</text>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
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    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0P7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14134" checksum="D6696A684C5A19AF" modified="2020-06-17" version="1">MRPLGPAKRENTIAGIKSGKPLREIAKDTEYSKSIVGRVHKEMNDKGANVVDSNGGRSAKLDKLTKRRAKRMVRIGERDSTPGVARSLKQDLNIDVPSEAVRKAFKENEFRAIKKKKAPLRKKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C172</accession>
    <name>A0A6A7C172_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C172"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="7690" checksum="A303063E018FA40C" modified="2020-06-17" version="1">MIRDGKRYQRNIEWEKKNRPCFYDRPRVDNLSRPHVMVALGASYARVLGVAILPTAFRRMLEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1C8</accession>
    <name>A0A6A7C1C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_281671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1C8"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="337" mass="35878" checksum="F7486A908B0A7586" modified="2020-06-17" version="1">MSDRAAAPTPSNPLPSSTAPAAQAKNVPSGSSTAHAVAAQQSDNVAHALAGAGGGLLSMALTYPLITLSTRAQVEKKKAATSTLDAAKRIIDREGYLGLYAGMESALFGITVTNFVYYYWYEFSRAFFQRTTNKTALSTVESMAAGALAGSATVLITNPIWVVNTRMTARKSENSESPSGDGKPQKAPSTISTFMKIVNEDGFMRLFAGVLPALVLVINPILQYTIFEKLKQVVEKRRKMTATDSFLLGALGKLAATTITYPYITVKSRAHVATGSGDKEGIIASLRRIVSEEGVGGLYGGIGPKVTQSVLTAAFLFAFKDVLYDMTVKARRTITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1J0</accession>
    <name>A0A6A7C1J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_299305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1J0"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="331" mass="38193" checksum="EF074FA119F1DEB4" modified="2020-06-17" version="1">MSLGLQVRRLASNGGFRSTLQIRQRVLRQQARFAFFGRDKGDQKENVSNPVLEEYNSQLERERAEGKSSAADSLKPGGLSSSSIFEDDRHIQKHLAGDEATESKSGTVNIGGVEREVPPMLAMLDPDPNARERWERKKVIEMVRKRGRLSKEEMIKRTEREHVSKSHNFKTSIKKLTKLAHQIAGKTLDEAITQMRFSKKGVAEDVLKQLEFARDEAIVRRGLGLGDDQEPTQIQLKNGRKHIIKNSSQIYIDQAWVGRGPYGKLPDYRARGRLFIMRTPWTHLTVVLKEEATRIREHAEREGRRRMKLFRKASTQLPDRPVVWQRPWYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1N8</accession>
    <name>A0A6A7C1N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_47188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1N8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14401" checksum="C8723E2A3D9D6E38" modified="2020-06-17" version="1">MSTRRERRVAHWIQLLSIRLPWLWGRLLHLILPSCSKSILPLSLTISSSSQKNVPLVIPPNSVPFLHARASSQKKQPWSCRYPSHPPTPHRIPLSITLVWTGNSDERKTTRLPARTGGRNYIQVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q5</accession>
    <name>A0A6A7C1Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_270027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q5"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13532" checksum="64F5FB9C2131DA65" modified="2020-06-17" version="1">MRSPLNYLRGGNLEVLKFGLYIMFPIGIMYYFGTNLESRFSIPNFWPKPEQTNKIPFEKDEIEEELARLRERRLRRRAKRLESEATDKLDEITPKHSQPFAEPEKSRKGWLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T2</accession>
    <name>A0A6A7C1T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_269979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1T2"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="426" mass="47091" checksum="58CE07B008EDA921" modified="2020-06-17" version="1">MDTAINDFVVAIVGGGLCGLSLATALKKRSIPFTIYEARSSFVELGAGINIGPNALEAFRLIDNSLGEAIAKLCTRNEQGKENVWFQVRLGAPSGEYEDARLITEVQSPPTGSMTVIRNELLQTLARTAGLGNARFNKKLVSLSQDFSSVQLKFADGTDARANVVIACDGIHSATRQAMLGPNHPATNPQYSDMGAFRAVVSVDKLAAAIGWEQARNSQMYLGPDAYVVMYPIERAQKVNVGLWPWHRVPWSSKEWVVPNQREKMKSIFESWGETVHRIMDVMGDPPFYATHHVPHLKDIHQGQVLLIGDAAHAMTPHQGAGAGQGMEDVYVIAELLTHIDKTQPLQAQIDAAFFAYEAVRFKRADQVAQTSMQAMEWLADFYTKNITLAKLEEFATQADKRLRWIWEDDIAGQATTAVELMKSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1U7</accession>
    <name>A0A6A7C1U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_199492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1U7"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="274" mass="30816" checksum="4E8D86819AC730B7" modified="2020-06-17" version="1" fragment="single">ESFSIKHINWYDASCDKMRNSPILVQNANGPCPLLALVNALVLSTPHSSSPTALVEMLRTRETISLSLLLEAVFDQLVSGNRTQNLPEVDELYAFLKRLHTGMNVNPSFITPGQFDETKEMRLHKTFNIPLIHAWVPSATSPAFFAFQRTAPTFEDAQNIQFQEPLLEEKRLAGGLTPDEQQTLSDIQTIKYFLTTWPTQLTEYGLTWLGKTLKPGQFANLFRNDHFSTLYKEPKRGALMTLVTDAGYSSHDEIVWESLVDVNGSASELFSGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2K7</accession>
    <name>A0A6A7C2K7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2K7"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="172" mass="19812" checksum="B03CEB9090D4AC26" modified="2020-06-17" version="1">MASNDITDPESENFQVTLTSSDGVEMKTTRKVIERSTVIKDMFGDLGASSEPIPIMNVTENVLRKVLEWCIHHQNDPPASLEDDSDSRKKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDIGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2N4</accession>
    <name>A0A6A7C2N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_275975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2N4"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000002">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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    </dbReference>
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    </evidence>
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    <sequence length="472" mass="52896" checksum="B91984B5F9DC372B" modified="2020-06-17" version="1">MQEDDSICPCSDCIYGISAKLALNDHDAHQHQSSQANGVHENQPAISNSPKPGLSTNKTLWAVNVPICYFHCPRCTFESENMLTVAEHVKHLHEPMRLHIGCLFCSYHSFDEDTMNVHVRHSHGSTELLFRCLVCAFQGSATAVQAHTKDEHGEPLVIFRCPFCEYKASSELLFWHSMSAHPESEFDLRCCLCNYTGSKIEVTSHTNLTHEKPMPKFSCCDCDFTGTEADVADHYTSAHAPKTKYFCPLCKFDSTSLSAAVRHVHGSHELPVQFYHCPLCSFRHESKANVVEHMKYRHYPSSSTESGYYCGICSFTGVSELSMRQHMEDEHDAFIGLNVGYGMFGPTSAFEFCCLLCSFDSAEEAEAVEHLSCHHSGIVNVRVMFCCLYCTFTHRASDVVRKHILKRHPSTGLSALRPPQCTEEQAPLYFDEFEGRRGDVDGRSNSDGHDGEDADTGELVVYWGVEDQSVTA</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR28112:SF1">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21216" checksum="D15F5569567E4497" modified="2020-06-17" version="1">MNPQITNLIVILVMMQASKKVPFDDPNVLNGVRALYILSNLIIAGLYLYTKYQIDKKRDMTILKYVEPAPMGSTEEPKAITTTVHAYDLQQLRGLFKAQLMGVAMIGVMHLYFKYTNPLLIQSILPLKGAIEGNLVKIHVLGQPATGDMKRPWKANAGMMGLVGQNANDVKTDKKSVETAERSRRGGVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3U0</accession>
    <name>A0A6A7C3U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_214247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3U0"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="249"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="628" mass="69001" checksum="B0C8DA8F175C18CD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C437</accession>
    <name>A0A6A7C437_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_275888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C437"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025341316" description="BZIP domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31975" checksum="74DF01E6839B9CDD" modified="2020-06-17" version="1">MHFQIFATLKATILLILHKIWRSPVFRHTLGGKQSSPINNPITEWRSSTEGSRAGFVASLDYPIPPPSSTHDSTTTQRPSPILDHTALITYEFFQPTDNAALNINDLFSTIIPILQVLAIAIFVADVLTKCFGLKPRAKKPSKKSFESQRTEKRLKPKHHGNHSLESRVYALSRRNAKLALLLKQERQRNVALRAEFSHLSPKWKKAAARMNEHSALRDRKRDDLFRMVDRFQQVVGKLREALGEVVDEENEEDGKVVREEKKEVQEGDGYTKSDEGEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C495</accession>
    <name>A0A6A7C495_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_256243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C495"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="33"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="433" mass="47409" checksum="DD04540585C14FB6" modified="2020-06-17" version="1">MAEEAARDGKRQNKTVEEAAPDNSLSNPDVLTKYKTAAQIGQKVLADIAKLCTNDANILELCQKGDQMLQDEVAKVFKGKKVTKGLSHPCTVSPSAYVTPYTPLVSETAEATKTLKAGEPVKIQLGAQIDGFGTIVCDTVLVGASPPIVGRSADLMLATYYANELLLRMMMPPGLLSTGSDEEKRKAQSQKPYSQSKMTQLMKKLVKSFDCNIVENTTCWLFGRNEIEDKKRIILSPTDGAKGEELPEVGEVWGVEVGVTTGDGKVKIFPERATLHRRTTTTYGLKRPSSRATLSEIQKKFGTFPFSLRQLDDERAGKVGIVECVRGGVVRQYEVAGSADGEPVGRLFTTVGITKNGIQRLAAPPAFNLSDYQSDKKITDEEILSILEQPLANPTKTKPKNKKKKKKSAKKQDTKAEDEDDEDESESDDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4W2</accession>
    <name>A0A6A7C4W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_199991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4W2"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="109" mass="12042" checksum="054C366DAB2582DD" modified="2020-06-17" version="1" fragment="single">VGVNSSSNGYDLDFESQIKGILLQNGGIRRIQGVLRQRLDEDGWSQSLREYITRLYRSGECETYDQAEAKVMQAIHQGSAAGTNTPNLSIPPTAMEGAVETIKKEIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C564</accession>
    <name>A0A6A7C564_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_212396</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C564"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="33896" checksum="5D1D734D0401F6A2" modified="2020-06-17" version="1">MAQVISSSGHDDMLHDAVLDYYGRRLATCSSDKTIKIFDIDSDTTPPSHKQTHTLNGHEGAVWCVAWSNPKYGVILASSSYDGRILIWREQQGQWQRIYEFTLHTASVNMVAWSPGEAGCHLAAASSDGKVSVLTFENNTFSHVIFPAHALGVNSVSWAPALLPGQLTSSVTGKQPEPQNRFVTGGADNLVKIWQHDAAGGKYNNVATLKGHTDWVRDVAWSPTPLAKQYIASASQDHTVRIWTLLAGKDLSDESAWHCETLDFEVAVWRCSWSMAGNVLAVSGGDNRVSLWKETLKGNWECIKTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5B0</accession>
    <name>A0A6A7C5B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="39395" checksum="33B30B7A38C860CB" modified="2020-06-17" version="1">MRRILLTQSQATILLSSAVIFVFTLVLFLSGYVIQQRTLSGLQAAIKPWVPPAPPRPGQSLPAALASSRHFSGIDKQQLLSLTKDVDWTRLAHVQIARTHHDVCSAIMVLAELRKSKSPARRMLMFPLDWAMTKNTRGDYSDPELSSSRRLMKLAARRYGVELRPIHPVSSVYTIASAFALKEVDRVLALQAPGLVLDAMALDALLAFYEETAPLAVLDGESEDATDLMLLQPDQDAHGSLIKQIHVNYNDSLLPTLLEPARLSFALQTLAPLHSLMPDDYFDGEGFLKNASYLRFRDPKLPGPEYDIPYSERVAARPKNKDADWTWTKLYGRFAQKRMEICGLELETWRP</sequence>
</entry>
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    <name>A0A6A7C5G3_9PEZI</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C5Q4_9PEZI</name>
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            <fullName evidence="7">C2 domain protein</fullName>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="897"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1379" mass="157136" checksum="AED204DA2BE6402C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2862913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="403" mass="45398" checksum="A48C0B87145594E4" modified="2020-06-17" version="1" fragment="single">TSPFFHLPHRIQYLIHHYDKQICPVLVTKDGTDNPYRRHILTLALRNACLQNAVAALSANNIRMRLQSCNSLLYTAHSPSQLTNPAALAEERLYRQTSINQLNKHLSRPDTAQDDSVLATLPILCLFHVSQSGFCHFQSQLLGVQTLLRLRRVSMKRSTETSAWVQLFFTWLDVMTSALNDREVQLHSNFSSNDVGTLELFSGCDRTLFALIERLGTANLLAQGRAVKRSLGAWTGNEVGYPDARTEFWGEWEDIVTKLNGWEGASGDRDIWHLNELYRYGALLYLTRLANPGLSSADEKFQGLVGRAMRHVTALGLGSCVNKFLLWPLFMVGTECTDGGQRSEIRRRCVGIQMESGFYNNLSGLGVLERVWRGQSESGSSNKAHQSRIEKKNLPKGRRNVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6I9</accession>
    <name>A0A6A7C6I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_255762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
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        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
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        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="751"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="559"/>
        </location>
    </feature>
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            <begin position="603"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="1197"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="611"/>
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        </location>
    </feature>
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        <location>
            <begin position="1203"/>
            <end position="1220"/>
        </location>
    </feature>
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        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1322" mass="145960" checksum="5E98EC5DA3F9B6AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6M5</accession>
    <name>A0A6A7C6M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6M5"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="17971" checksum="C8CF716B9F5F3E22" modified="2020-06-17" version="1">MSASAFFYGTLMCEPVLSRVIGRDASTLPQHKALLEGHVRKRIKGMDYPAVIKAPENTANSVLGVYASSLTEMDIKRLDLFEGEEYTRRNVTVKLLEGDEKTVQTQTYIYKATPADLEEGEWDFEAFKRDKLDIWAGKSADGGEGTGGRGIGGDIWTSVSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6T0</accession>
    <name>A0A6A7C6T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6T0"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="375"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="604"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="728" mass="77104" checksum="9C75A55AC2A4A6F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7C6</accession>
    <name>A0A6A7C7C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Shwachman-Bodian-diamond syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_211801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7C6"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="30737" checksum="1046ACD80A4274CE" modified="2020-06-17" version="1">MPSAQINQPSNQIRLTNVSLVRIKRGKKKFEIACYKNTVSSFRSGAETDLDNVLQIPNIFLNVSKGQVAPNEELKKAFPGMSRQDVVLEILKKGEIQVGEKERDAELERIKKEVIEFVSSRVVDPKTKRVYTSGMVEKALDQIAANPKEEDGPKWRGVTTTKSAKLQALEAMKALIAHQPIPVARARMKVRVVGPAAGVKKMIVSPKEGQEESGKVPIKDIILDWVEQVVSEDVSGEEWEVVGFVEPGAFKALSEFVSAQMRGKARVEVLEMAVTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7G0</accession>
    <name>A0A6A7C7G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7G0"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28601" checksum="823ABEC667113839" modified="2020-06-17" version="1">MLEARLEQANLLKKVVDAIKDLVQDCNFDCNDSGIALQAMDNSHVALVSMMLKSESFSPFRCDRNIALGINLSSLQKVLRCAQNEDVLTVKAEDAPDVVSMTFESADNDRISEYDIKLMDIDQEHLGIPDTEYAANVKLPSSEFQRICRDLSALSESVSIECTKEGVKFGCTGDIGSGAVTLRSHTDVDKPEKNVDIQLSEPVALTFSLKYLVNFCKASGLSDQVKLCLSNEVPLLVEYALSNNSYLRFYLAPKIGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7J0</accession>
    <name>A0A6A7C7J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7J0"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="11921" checksum="90C1BDD1A4A3B48C" modified="2020-06-17" version="1">MAGLTVLYHKGTTLDMDHYLKVHIPLVEKLWGPYGMESAKVYKMDDDAAFCAQATLTWGSLDQIKKALAAPATKEIQDDVKKFADKEPIFIFGETLVSTGQEGAKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7J5</accession>
    <name>A0A6A7C7J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_292910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7J5"/>
    <dbReference type="OrthoDB" id="5783575at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19346" checksum="5EBC6C4787D20813" modified="2020-06-17" version="1">MRTHVTPRGPVPVINQDPVHCHCDGHDFFVPRRILNHMGLCRAQLSSMDTLGAVPNAPVALPIHKVSYHEIYFVMQWCSAHVGDEIRSREMREVLRQPYSNIADACPAFTESDHIYFARLSPSGLARVISAAYELEVEGLVLQGTKVLAERVRGISPGDIKRLIVDGGGVRGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M6</accession>
    <name>A0A6A7C7M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_262182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M6"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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            <end position="171"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863440.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="807" mass="91530" checksum="8AC3517EED916A22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C852</accession>
    <name>A0A6A7C852_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="30836" checksum="52946C3B27A59A62" modified="2020-06-17" version="1">MSPSSSSKRPFKRAFEKQVNTNMQKMADADRKLSPATLETGVDCGDEDWSEKRDPPPRFSTLFPAAPPSFPERSVERPAELPPRPSRAPGVFLTTPVFIIIMATLTLEAMILFAYTTIGLYSNLPNRFVPNMRQVPQAINVAPNIVVPAASNGPAETITLISTTIVTTTASTTVTTTEATTATTTDATTDTTTATATTSVTPTSTADESSKAAVMISDILGALSSRWTSNAVSTVTAVPSSTVFLTVVPPQSTVQSVTYLTVNPGGTPITSKTRTTVTSTTVIDATALPSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B8</accession>
    <name>A0A6A7C8B8_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_280039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="443" mass="49269" checksum="D4EE6DF40966C08F" modified="2020-06-17" version="1">MSTPSSIVVVGSGVFGLSTAKALTERDEYKNSTITVLERLEFPAVDGSSVDSSRIVRADYADEAYARLMNEAHPIWRGEFGADGRYSENGLCIVSGKASSGEEALYLEKALESLRDGLGLKIGKKEDGDQVEVLDSPEDVKRAMHGMGGDCGKRGYINWTAGWANAEEGVRHMRRLIEKTGRVEFRQAEVTRLEFSNGLVQKICLANGEPLTADLFILATGAWTPKLIDLTGIATATGQCLAYIELTSDEQARLGDSPTLLCEDNGIYILPPRNNILKIARHGYGYANPIEIPHPELEGKTLTVSLPRTTQDNPDLSIPPEGSNELRDYMVKCMPFLANRPWKRTRICWYTDTKLGDFLVDYHPKYSNLFVATAGNGHGYKFLPVIGERIVDIIQRKDRDELGAKLRKKWRWGGARPDENLVWTEDWRGGQKGMILDDELAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8I2</accession>
    <name>A0A6A7C8I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863750.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16632" checksum="ADBEB093AF10DC9E" modified="2020-06-17" version="1">MSELNTNVASLRVRLAALRTNASTLKKRFTATSTTVISDTTITNEARELFKLHWNTESVGFALAGLILDKLEVIVEHNALEERKLLNDLERNIAGLEKVLVDWGPAVAEYEAFWTSRTRNEQAAVNLAELMERKMVLPKELHCMVEH</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="408" mass="46040" checksum="64E4C16501DA32A8" modified="2020-06-17" version="1">MALNDCPLPDVARALELYIRPRHEVTNIRNALHAHLRDHVCEQDAPLTSVNLDFDHKQAKNPLLLSPSGLTGVRKAYVEALRAHAAAWTEYESMKRGLNQLGTSNEMSARPKTMASDFFPLLKQRERRRKLRILERAIPQINAEGERVVSQRPEDAVDHKVGPLPLPPSNEALHGVPTDVEEQIFQLKRAILTCQKHKDTTKTTVPDELSALQQAHMLLTEWIEDQLSIIGAGEADDPSSNVMPGETLDISHVEAMYERYVAIRQRLIDTVNRTSPPDISREYQTPGPERPTSATDRVAVDAEAVLPYLSRLGAAKRREETAERQRSQLRQVMENGQSDNGRLVARLVDESHLVEPSTMKIDEWATAARERERTTETMVRQQLQTGQAFITQADNLLEERAHINIVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C9M2_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="475"/>
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        </location>
    </feature>
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            <begin position="87"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="491"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="522" mass="58283" checksum="125759322AC8FDE9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P2</accession>
    <name>A0A6A7C9P2_9PEZI</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
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    <dbReference type="GO" id="GO:0005741">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
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    </dbReference>
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        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
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        <property type="entry name" value="Omp85"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
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        <location>
            <begin position="161"/>
            <end position="478"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863715.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9R7</accession>
    <name>A0A6A7C9R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_49459</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="123"/>
        </location>
    </feature>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="167" mass="18993" checksum="4750E6C0280FD0F9" modified="2020-06-17" version="1">MATAVLCVKPFSDADEVNNHPRKARGPTIEWTKNDDFWTRRIGQRWAKHLGLDPPFEEYRLDNLPTGYAGYVRPKIYGDPSSVRLNYLYGHPSGSRYNSGESFWPHFVWLQEGMEGECECKLCGKGKSKKSTPMVWEEGQDEEDAIDDEEEEVGEGVIPINSFSDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA22</accession>
    <name>A0A6A7CA22_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="406" mass="46670" checksum="65536DE823800BA4" modified="2020-06-17" version="1">MQASGNEFYGLKWVEQLADPRPEWTVELDVNAIKYEAEKAVGPENTQVSFYAQGGFNRLFEIVAGNKTYLMRVSLPVDPYWKTSSEVATLSWVEKNTTMPVPHVVAYNSNRKNAIGFEWMLMTKLPGVNLSKEWRNVSFETKRYVTEQIAEYLVALFSKQKNAIGGLHEGSEDRGRIVAMEFFWNKRLSYDVNRGPFKSSHDWMLARLSVVEQDWQETLDHSQDDAETYDAEQIIIVVKALRGILDVVFPPTSTTEPSMLVHDDMHKSNILVDVDSGRVTGIVDWECVSWLPLWKACDHPHFLCDGKRSTEPVRGSYTVGKDGEVNELYWENLMEWESTRLRQHFDNIMQRTCPEWVQIYDRSGLQRDFDGAIIQCSAEYARPGIMDWIKKVSQGDLTARIGDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA89</accession>
    <name>A0A6A7CA89_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_274128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
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        <property type="entry name" value="PAZ_dom_sf"/>
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    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
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    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="306"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="587"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="935" mass="104020" checksum="1BDD343D0C3A07A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAA1</accession>
    <name>A0A6A7CAA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
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    </gene>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
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    </feature>
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    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
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            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="419" mass="45801" checksum="7A8621D682DFC862" modified="2020-06-17" version="1">MATTQLRIRLHTQSEDLKLPSDHGPVVVSTSLARYQLSILVNKLLQTEKPIPFEFLIQSQFLRTSLGEFLAKNGIANESVLNVEYVRALAPPLYVASYEHEDWVSAVDAQDERVLSGSYDGLVRVWNEVNEIVAMGEGHLGPVKAARFAEGCVVSGGMDRTVRVWAKGLRPVMELYGHHGPVESVAVRGSKVLSASADGRVGVWSTSSTALPEASDELVPVANKRRRLSVAENQKGPLDMLEGHHAQVSDVCFDEGDPTVAYSTSWDHCVKTWDLTTGMCVDTRSTAQSLLSICHLQEQSLLAVGTVNRHITLVDPRTSATNVSVMTLRGHTNVVVSLDRAPDSATQLISASHDGTCRIWDLRSIHNDAAEKVSESVYVIHRKSAEGKKTTKVFDVCWDKQLGVLSAGEDKCIQVNRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAB5</accession>
    <name>A0A6A7CAB5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAB5"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="323" mass="35183" checksum="5D22143358F1654F" modified="2020-06-17" version="1">MSAATANFVSSTNDALSRKRGRAEDNQTDDAQDWSTDTFCFCVNESSPGGPETLARAHDQRQHHRPRAATRTPAAPVAPSVSVAGLAGLAFLVVAKLFTFGTNVVRGFYAGGGKGYDLSPLPPREFLGDFEQDNQEATPTKATDVGAETPLSSSKTPSRPPYKRRRSGRDSWVVPDESLLSPTRCGSIPTRSATLGRRSYTNRRSLRLSPSGGSRPLSPVHIQNHSYSHHSPVRRASVASTNSLGRSHSRAASAASAVFVTPEAERLVRRRAKQDRLADAQMTDMSRKLEELIRMGQQALGTKVEVCDDVDDYDENVEEGEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE8</accession>
    <name>A0A6A7CAE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAE8"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="658" mass="74039" checksum="AA5E62AB9617BD99" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG9</accession>
    <name>A0A6A7CAG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_209050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAG9"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025496060" description="tyrosinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="601"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="679" mass="74063" checksum="03B89BDB5A3D6E1F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK1</accession>
    <name>A0A6A7CAK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIM1</name>
        <name evidence="16" type="ORF">K470DRAFT_284202</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="10"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAK1"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
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            <end position="422"/>
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        </location>
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        </location>
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        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
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            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
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            <end position="276"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="582"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2864470.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAM5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_254474</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
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        <location>
            <begin position="15"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2864139.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
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        <name evidence="14" type="ORF">K470DRAFT_297746</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 480.64</strain>
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        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
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        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
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            <location evidence="2 10">Nucleolus</location>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="UTP25"/>
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        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
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        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="211"/>
            <end position="453"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="618" mass="69789" checksum="15CAFBADD96E1BD1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAX0</accession>
    <name>A0A6A7CAX0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3 6">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_209598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cut8/STS1 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
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        <property type="entry name" value="FI02826P"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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            <end position="59"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="276" mass="30932" checksum="1650F62F49087144" modified="2020-06-17" version="1">MVSDGAFAPHLLSRRSPAFPHDRDVGNAHRKRKASEDRDDRMSTSPTASPAMPHIASSHRTKRLRMAPLPASQSLPLNRVLESLPREKLTTLVLDLCETRQEFAAELANRAPRPTVDETMTVLSRYERLFRDAIPKGNVTPNYAFGRTRHQLTDLITALHDYTSAFIPPRETQPFVSLSFLDAATNLIHSLPNWNSYEYMRLKNEAYGELAGPWAVAVVESAKKAAGYRLQFEGWDEKLLEHNAKTGGRFTTAVAELESLGFGTNASSTVTRRTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CB07_9PEZI</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB07"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="63" mass="7280" checksum="7D00A25EA4DEFA19" modified="2020-06-17" version="1">MSLWQSYKTLQPRTRMLLGAGVMLYAVLGMRYSDSFGNLLGITPTARDEEELKEKMKVRIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBH8</accession>
    <name>A0A6A7CBH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBH8"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="250" mass="28124" checksum="F380AACBB4452F00" modified="2020-06-17" version="1">MKRPYEVEDDAQSIISTNSSFKRARGSFPHDNDHDTGGDTDVDMDMDMLYDNKQYDPHDNMAMDLDFSSSATRPVQVRQHVRARHPPQQSFFRTALQSSPLPQSSPLRQRTPPNSSPLHTLSFDDDNDEENYKRFSRLSVSDHLEIMQSSSSVYSLPSSSSPPPITPASSSAPEVNKVLRQRQRSGAQSSGSPYYVTSAKRTASLTELNDSTGEGPRQPLRTIRMGFTPDCKRCQMRIPGHLNHFVYSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBK2</accession>
    <name>A0A6A7CBK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_208473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBK2"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="22880" checksum="2BB9AA9BF51F5D2C" modified="2020-06-17" version="1">MFPGVSLESLNMEDLASSDPILPTFHIYGAPQSAANPFDYTSRNTIPDYTLPNAYRVGNVPSIEARMDALSDETLFFIFFSQPRDVAQQRAAGELERREWRWHTVLRQWMRSDSPPGQSATATGPNLALVDMAPTIPAGAPRIPIDNTTEQGIFIFFDLQQWKRVRREFKLNINDIDGKTMPRGPLSSLAANGVAYIRSQPGHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDS9</accession>
    <name>A0A6A7CDS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleoporin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254143</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1780:FF:000003">
        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="13">
        <location>
            <begin position="101"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="12">
        <location>
            <begin position="659"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150628" checksum="B32BDF7BCD305216" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP41</accession>
    <name>A0A6A7BP41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_14499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006064">
        <property type="protein sequence ID" value="KAF2857123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP41"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11523" checksum="8C3330C1169BAB9B" modified="2020-06-17" version="1">MLESNTQFNRLPAKIRIAILMCLDGDHAAIFIALSVCKECADVLTDLLWKDASPDKFKGLPLAKKQYYANKVQSRRNRSIAQSFLSTLKTLFSRDCAPGIMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPH7</accession>
    <name>A0A6A7BPH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_261029</name>
        <name evidence="14" type="ORF">K470DRAFT_296726</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
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    </comment>
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        <text evidence="3 10">Belongs to the histone H4 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0488">Methylation</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857233.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857938.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11372" checksum="504DA6BE1E631BEB" modified="2020-06-17" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BPW9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Nopp140-like"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="454" mass="51052" checksum="3A70193274F433BF" modified="2020-06-17" version="1">MVLPQTIWTNRIIPSPRMVDVLTQIGHFFDAVGFSRSYTALFDEAKAHGMPLMVKKWKRDMEVNGPSIPLTDLWEEWYDHFKRHPSLPDEAYRPREPDDEDTLSSSYTTYERWSSSEIERSDREIHADNEGHKTGFVDDEAESSSDEDDDESSVSEEDEKPVTEVNGIKISKPAKRVEDESSSSSSSSDSSSNSDSDSSSSRSLPCDRRDIRRLWGLEDKTKTVHPTETKKSKKGKIAVAQGNDASEVQKKKKKKKKKYAASLSIKQKQGEAAPSEKIPAELLSKKKSDMMSKKKSDKVSKKKSDKVPKEKSVEVSKEKSEKTKKTKEMVPATTVDSPKTSSSHNDKKRKASAIEEEDANQSHGINADRLKRMATARTGPRAVKESFSRIPRDIVVDPRFASNAYVPNDYSNQAYKDLSVTRGKGFTKEKNKKKRGSYRGGIIDTAPKGIKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ85</accession>
    <name>A0A6A7BQ85_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_172657</name>
    </gene>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2857443.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22900" checksum="E62B94751F1ED5C8" modified="2020-06-17" version="1">MLDIWERFRMILNQMRENGYFSFRYDAASTARSILFHIDLEPRNIMVAKVIDDVGYKIDKVIDWDRVQAVPAMMTRRPPIWLWDYTNEMWAHQTGVAIQSVRSDFDDDAGHLDPTRYDAGNGRLSPDDQQIRDHFENQLVQGLGKIYQGYDRSDYFEEAYGKGRWIHRIARFAFEGIPCNGAFTSLSTLTRNGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQI1</accession>
    <name>A0A6A7BQI1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
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        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MU006084">
        <property type="protein sequence ID" value="KAF2857045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQI1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="172" mass="18949" checksum="1EEA7D4AD920C682" modified="2020-06-17" version="1">MPNPIVFFDVTLGGEPLGRIKMELFHDTTPRTAENFRQFCTGESKDSRGQPQGYKGARIHRVIKDFMIQGGDFLNGNGTGSISIYGTKYFPDENFTKKHDTPGLLSMANSGRHTNGCQFFITCQPTPFLDGKHVVFGKVVSGMDVVKKIEGTRTNKDDAPSLPVLIAQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR07</accession>
    <name>A0A6A7BR07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_161007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR07"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18518" checksum="101659912B3BA38A" modified="2020-06-17" version="1">MRRCRDINPDQHHRIPPFAVQRTIDESKPDSPSIEFKPGRRPNPSPAVTTPRPPSRPPPAPPATIPPPPTIRIEHSPIRIEYAPLRIEHSEIKIDHGPRIPIHAVGRMQRESDSAMIRQKTECEIVRHIAGMGFPGPMVREVLRKTGTNNIHQVELAVDVLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR60</accession>
    <name>A0A6A7BR60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_160726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR60"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="100" mass="10322" checksum="CBDA54289608BAA9" modified="2020-06-17" version="1">MGRSLSAFACGLVRGSSGAWPWLNVGNDSMGNEVLCGSSGVYFVVVRKAGAERSRRIPLPDGRGPVLVVLCEPSMLVPASPAIKCVQAVVSAGYRALSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR61</accession>
    <name>A0A6A7BR61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR61"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17272" checksum="B3227CF591853152" modified="2020-06-17" version="1">MSSYFGPLRTTIHERPNWYKSHLGLKLHSRRCMKSLSKEGCTKSEVEYLWCAANCVIDPRRVWKSASIICASAHIVTCHANSEVETVMMPDKESYPLRSLKDDLFPLSSTPLTNSLSPHQNPCLPPPIQPSPASSQKGTYAIHTNLIPPSLPGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRB6</accession>
    <name>A0A6A7BRB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_159204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRB6"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="457" mass="49982" checksum="C154FE1F1632FEF6" modified="2020-06-17" version="1">MAPGAIEKTEQAIGATLNATAATFKPAASHVHTESSQAAIETEAAHAAHNYHPLPIVFARASGCSVWDPEGKHYLDFLSAYSAVNQGHCHPKLVKALTDQASRLTLSSRAFYNDVFPQFAAKITKMMDYDMVLPMNTGAEAVETAVKIARKWGYKVKKIEQDKAWVFGVQENFHGRTFSAITLSSDPESRDNYGPYLPNVSSVNPSTGNPIPFNDAAALEEVFKKYGPQTAGFLVEPIQGEAGIVVPDEDYLKRVRELCDKHNVLMICDEIQTGIARTGKMLCHQWAGIRPDLVLLGKAISGGMYPVSCVLGSKEIMLTVEPGTHGSTYGGNPLGSAVAIAALEVVEDEQLTERAEKMGEIFRRGLHDLQKREPMIQTVRGKGLLNAIVIDESRTNGHEAWDLCMLMKQKGLLAKPTHQNIIRLAPPLVISEEQVRDALRIIEEAVHELPQSAKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRG5</accession>
    <name>A0A6A7BRG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006048">
        <property type="protein sequence ID" value="KAF2857355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRG5"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="696" mass="76569" checksum="1CF946DF1C790A79" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRH6</accession>
    <name>A0A6A7BRH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_260885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRH6"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="111"/>
        </location>
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            <begin position="393"/>
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        </location>
    </feature>
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            <end position="631"/>
        </location>
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        </location>
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        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
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        </location>
    </feature>
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        </location>
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            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
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            <end position="439"/>
        </location>
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            <begin position="463"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857365.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="750" mass="82977" checksum="B31C6AFB20AA158D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRS1</accession>
    <name>A0A6A7BRS1_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_253241</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2857455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="236" mass="25967" checksum="A18FE8FA00C8CEC9" modified="2020-06-17" version="1">MPSKVILFDLGGVVFSSPFRGIARFAERHNLSNTSLNRAIAASETWRAAERGELFITKTWFISFGEEVTSLYIKANEDGKGNAKIDGEDLFRSMMDAARETDPHIFPALKRLRRVADAKGFVIAALSNTTAPSREGAKGRDARLEGLFDVFVASADVGMRKPEERMFRFAVGKVGELLGRDVEMHEVVFLDDIGSNLKAARKLGMRTIKVTLGKTEEAVKELEELLGVSLGDTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRS7</accession>
    <name>A0A6A7BRS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_148928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="117" mass="12887" checksum="3CEB4EA0269E9FEB" modified="2020-06-17" version="1">MVGSIVGPTKRQPGKRPTGWQRGYFQGSINGCASKHLSHCLLTFTWQADHPGRIQYVFGVAQIEKKRQKAMASNSGKEVTYWSAIYVSVVLHIRVASFAGHHNMSTISSLTTPSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX8</accession>
    <name>A0A6A7BRX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_222555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRX8"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="205"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="33062" checksum="8FE5C23821FAADA8" modified="2020-06-17" version="1">MATDKPLPFVYQFAAGAVAGVSEILVMYPLDVIKTRVQLQGKVPVPGQDHYTGMLDCFKKILKNEGPSRFYRGIGAPILMEAPKRATKFAANDEFGKLYKNLFNVPNMTQGLSILTGASAGVTESFVVVPFELVKIRLQDKAQAAKYNGIVDCVSKVVKQEGVLALYQGLESTMWRHALWNSGYFGCIFQVRALLPANPTKDKSTQMRNDLISGSIGGTVGTILNCPMDVVKTRIQNSSASIDGLRKYGWAWPALGTVLREEGFGALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRSMKGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSG1</accession>
    <name>A0A6A7BSG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSG1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="54" mass="6005" checksum="BBD9768C954C9EBD" modified="2020-06-17" version="1">MVSRVAIPVLVGMMLLTGVCNTLLTKYQVRIVADSHQTVPINYVYVGYAMCCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSS5</accession>
    <name>A0A6A7BSS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="8" type="ORF">K470DRAFT_259878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSS5"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="57901" checksum="24DC1FBE3D2235B7" modified="2020-06-17" version="1">MQVPEQANGDAMDVTYPDDSSDESHVVPETANAEIAEITARLRRGEPAGWPERGQRCSYSRELDALDPLRHLRKQFLIPSTDSYNKTKLEDTVPDDFTGSESEERSATYLSGNSLGVQPKAVRRYIDNQLETWASIGVHGHSRLMENSPLMPWLDMAERCSRQTAPLVGAQPHEIIYMNSLSVNLHLMMFSFYKPEGRKTKILCEWRPFPSDFYVIESQLRIRGMENITDHIITVRPVNEDSYLSTADILQKIEANSGELALILLPGVQYYTGQVLDMARITAFARNRRIPIGWDLAHAVGNVELSLHDWDVDFACWCSYKYLNAGPGAISGVFVHDRHGQVQPRYRPRLTGWYGHERSTRFDMDNIFRPTPGAAGYQISNPSAMDLAILSAALTAFEHTSMKALRDKSLLLTSYTEHLLELTLAKCPQPYPPFRIITPRDARERGAQLSLLFHHDWFDVTAECLERHSIACDKRKPNVIRVAPVALYNNFKEVDYFVNVVALALGSRFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSY6</accession>
    <name>A0A6A7BSY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_266105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3783534at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1375" mass="153141" checksum="0EE2B200889A0247" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT36</accession>
    <name>A0A6A7BT36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT36"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="45444" checksum="CDABF0BB3895DC2C" modified="2020-06-17" version="1">MTVDEVRQKREKRMVHEMRCTDWTKKEEAVVRDSQADTDEALVEVKGEELAAVTPKKTRFEEVPSSQRTEETSLDAERMSFQTPKRTRFVEIPSSLSSESVIQLSTQKSKRFKSIETPPQKIALSQGDLDATPSKMQSSPLKYCHVLGELEGTPTKRQKLGYASPMQRYSPGQSLAETPIQRRSLVVEGFDVPATPPKSCRSDLNPPRRPLPKGSPTPREFRVVQDSQGTDDVFLDDEVQCTNEQHDDQQDDQEDEQYYEDEEAYEEEELQFTYDPIHSALARDAARFMGVSQRRDSTEGEASEDPTGLKPRLRPSQQSTVIPTQSSPPVPKPSQKNAASSSPYHTPRKPHLQDSVFKSSSPLPAPPWSSPPTAISDKSGKIRETLEDFSLPPPPPLSSSSYLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT71</accession>
    <name>A0A6A7BT71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="7" type="ORF">K470DRAFT_260356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT71"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15683" checksum="5169E9BC1E243F67" modified="2020-06-17" version="1">MATTAVADTTLLLKEVIANLYILVNNAHGYQDEQTKENIANEIKRLVSNLIDLCQTSQRLPTYIPLDIIEYVERSRNPDIYTREFVELIMRYNQELKGRTDAFASFRDVLGREMYSAIPEIQTEVRNIVEAAGGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTD4</accession>
    <name>A0A6A7BTD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_221211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="365981at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear origin of replication recognition complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
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        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="47622" checksum="1B89E5BF360E0C70" modified="2020-06-17" version="1">MDQLQSQWPCRRPQIHQLSALLGADIPTLVVHGPKATGKSGVTRSLLETIPYKWTTVNCRESITGRHLLEHIVAAVHASLDCEMPARCESISALAVHLETMLENESRFILMLDGIDRQREALATLTPAVALLSHTIPSLTVVLIARHPSPRLCNLPGIPHVYFPPYTRQQSMQIMSQHPPDIFLTRESDDDDDDATQEEDKAWLWARFCAAVWDSLGQHAARDLESLRELCDRLWRPFVEPITKGEFGPRDFSRLLVAQRRLFQDESALQDVIVSGMESDSLELPHYTKWLLIAAYLASYNPAKMDQVYYMRTTERKQRKAGARGGRRGRGGARGSIRPLLSTTSFTLDRLLSVLHAILPHDDLRTTVDVYTQIATLTRLRLLVKGGVGGEGLDGKWKVGSAVSWEYVLGLARNLDFGIVDYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK9</accession>
    <name>A0A6A7BTK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_157202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006026">
        <property type="protein sequence ID" value="KAF2857838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTK9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="21100" checksum="E787C3805CA04D45" modified="2020-06-17" version="1">MMKPQKEALFELCGNFLKEQNVSQPVLEGGDRREELVESRALANTKTNHGFATAQMKWSKKCDTWPAGITFEDAFGKWYCHGGSCDEPSPRWYKVMKAIGCSYRPPSCTVLSGHELACTNIKDGIMTLPPRLARGAPSRAAALRAHPRQGNRSSDCGTIPATSTNDRRRPANSDARMVPCLPGRSNGCITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTR7</accession>
    <name>A0A6A7BTR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_237189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11886">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polarized growth protein (Boi2)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035551">
        <property type="entry name" value="Boi1/2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="869" mass="94609" checksum="CC238F83594F1C77" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTV9</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="42920" checksum="A33CA82E0BEE6FA3" modified="2020-06-17" version="1">MYAAALIIIGLSLMHTANAHFCMLTPSPIPESAQKPPLQISGSDFPCHGANIPTSGGATMEAGSTQHLSWDLEGGNSYIIHGGGSCQVSITYETEPAKLKDPKNWFVIYSIEGGCPTNSVENYLNGTYKGPQGDYTGSVLCTDPRSNGVDCINEFDFTIPKGVKSGHAILSWTWFPSLGMGRDMYQNCVNVDLVGGDGSEMGKFPTLFVANVHQIGGEQCPTTKSYDLQFPFPGAYTTTKRPPESATGATVLPFATPEGASCSMNGAPRGDLAAQAYDQPTSTASPQASPADQDQNAPTDITTLPPSLSKSAASVASKQTTQPVCLTNGKPGNCITYAISTLATTAKASPTPTKAGAPTPQHQQPQPAPTQKMCNILVCGYRSTLRMILGIRDCEWQRRACPKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU46</accession>
    <name>A0A6A7BU46_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU46"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="2">
        <location>
            <begin position="166"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30821" checksum="94710492AC32EB42" modified="2020-06-17" version="1">MSTLTDYTTLPLSLPPQPSFPTKAKHYIYIRTHTPNLPTATSNRELFLSNIPLDATPQGLKSIFSGLGGGKIEHITFDEAAPSRGLRKKQLGRRKRRASTAGEEVGTLPRTVERELHPSGRAIVRFVDGVSRDAALREVKRMSKKGMEWRDVPLGVQRYQKMVEMRYPDPVVLQKSVDEFMEEFNREEERERKKRRTSKVDDDGFVTVTRGVKRDEAPREVKKVGKEDFYRFQMREKRKADEKDLIKRYERDVKKMEAMKKLKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU69</accession>
    <name>A0A6A7BU69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU69"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="31604" checksum="29D267430599B20E" modified="2020-06-17" version="1">MDSYEPVSPGKRGRACEIESDKTPAAEAEADNCKGEAKVNPQDKSSPAKEATPAKDKAPTSAKSSSAAPTNPSSASRSEAPVRKDEASTKRPQANQTDKSSSAAVNTTPQVDVKVNCKSSPKERIPQAKSSAVNPSNKSSVPAGTGSSTSTPVPPKENVKISSESPSAPVDSPLSNFATPKVNAKVNSDKGTNSLSPSAPVDSPLASCATPKVNVSANPDKSEASTKLPDAVPVTPGSHGKADTFAKGQETDALLSPLHTAFTQNQEQGFQLSKSGKILRFGGQVDMGMVMSIAEVLQVGLAGRILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU70</accession>
    <name>A0A6A7BU70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_221571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU70"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="309" mass="35594" checksum="57D20F48CA54C455" modified="2020-06-17" version="1">MIKVLERAPGLDLIKGKTLVEIGGKPLLKVPEDERRQAFDIAAEVVADSVKRHYVPPIKLGPHEEATVKLSSETTFHGEFDEFAELHSLSGPPDSDTACVKRIRSRVSNAIKSQADIFFVPPKGITIVSDIDAVLRVSQYMPRLKESAFKPYRPWLNMPQIFAKFKTRCDIHFHYITNAPSPFTDMYMRFLVHFYPPGSFDAARTNVRFPSEVNLNLILEKFPNRKFYLLLDMTKRYRFTTMAPSRLECILIRDIAPLNYREKFKIANLKENWKFIPKTKIRYFTKPDDLMGLDFDAGGCGIPKLQKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUI3</accession>
    <name>A0A6A7BUI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUI3"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="18606" checksum="67B2505B51C86A14" modified="2020-06-17" version="1">MEELKAGLVELYKTRDLADLTINCGSYNFYEHKAILGAQSDYFKTLTNFKEGKTNIINLKAQSDGDEGNDIQNDDPAAIKHMIDFFYHLDYTAAYISPAPFPSSRATKSKGKKCGYARVGHHTKTSSSFQQLEPTYCRYHSKCYGCDDNLEGSPSGFPTQQSDNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUJ6</accession>
    <name>A0A6A7BUJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUJ6"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="32831" checksum="75D9327E7C1C2640" modified="2020-06-17" version="1">MAHRTSDAPTLGGEPPFSSWLAVTPLAFALLPALAGLFFPNGSAFVTDLLLLSLAAVFMHWSIRFPWDWYRSAQAVGLRGVKKESKELRRHELLALTATFVLPAVAAGLLHLVRAQLSRTSTGLVSDYNLCIFVLAAEVRPLRQIARLISRRTLYLQRVASESHDPGDQQHLAALAMRVAELEARPPAHTDAEEMRKRYESRLQALERAVRRYEKRSTTLAMITEQRLNRLDARLQDALSLAAVAARSSNRVCDIILAPVRASWAACTWPLVTILTWYRRATLRKMKPPKAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV38</accession>
    <name>A0A6A7BV38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_220935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV38"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="238"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="490" mass="52796" checksum="333B5ABCB3B0F538" modified="2020-06-17" version="1">MSSPSALETSSFTTAEHPPTATKETAPSTAVSTEEAISTRTVSPRAVSPPTAQETANSTPPSPPPVHTNRIFALFKGTYHNFYPATYLSTVTPTTYSVIFDDTTPTTLPAHQVRSLSLRVGDRVKLDRAGMRKETYTITKLGRHATPSQNLSDINGHISVWVKPHSKKSKSPETEVLVTNIYLTHTLWKAFAARPFTPQGRSHGCASRPTTPAGSGSHPPTPGSRPRRAPSPGNLPSKSAGLFSNMAFAISLGSNTSYKSSLTSTITAEGGTILEGFDALFTPTDFTLHPHYENLGFVALLADRHSRREKYMQALALGIPTLSHRWVKECVGERGVVGWEKFLLPAGESVLLDGAVRSRTLPGCRVANATLGEMLRNRDLLLRGVTVIMVGTKRGGEEKRRTYEFLLRALGAEGVHNVEGAKEGGELARTLGSRVFVYVHGRGVQDAAAGVFGKKGKRKRGENGLCVSDGRVTVVNDEFVVQSLILGCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF6</accession>
    <name>A0A6A7BVF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_219802</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVF6"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Sun H."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF-1"/>
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    </dbReference>
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        <property type="entry name" value="Release factor"/>
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        <location>
            <position position="1"/>
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    <feature type="non-terminal residue" evidence="7">
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13840" checksum="3C6B0FE6DDC26BEB" modified="2020-06-17" version="1" fragment="single">TLSRCLSTTAARSKQPAPLPRLPDIPESEITESFLKGSGPGGQKINKTSSAVQLIHEPSGIVVKCQETRSRELNRKYARRLLAEKLDLMQNGEQSREKVKAKRILDKKKSAEKKRRRKYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
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        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1224"/>
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        </location>
    </feature>
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        <location>
            <begin position="1250"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1283" mass="139675" checksum="67721743D53C4D2E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVQ6</accession>
    <name>A0A6A7BVQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
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        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="13" type="ORF">K470DRAFT_272319</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 480.64</strain>
        </source>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="683"/>
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    </feature>
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            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="783" mass="88611" checksum="7075440CB9117B99" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW60</accession>
    <name>A0A6A7BW60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_249697</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW60"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="236"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="459"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="527"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="809"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1069"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="595"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="748"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2859292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125731" checksum="F3438486E06633D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW90</accession>
    <name>A0A6A7BW90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_258643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW90"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="107"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="265"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="938" mass="104478" checksum="D87117196E1F337F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWN5</accession>
    <name>A0A6A7BWN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWN5"/>
    <dbReference type="OrthoDB" id="3942661at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="47013" checksum="B03924B2BC0C7A1A" modified="2020-06-17" version="1">MSTIPAMTSKQAKAAYRARGCPTMTDKEKRQMERDMELSRREEVIKEQKRKAELRKKKAEAAVHAKEEAKAMVGSQRICDRYGHLSSQYHLGAFFGEKKRKNVADTSKPEEFKSKEPKSKEPKSAAPKAKEPKPDETAFDDSDLEDEVLLEVLDSAKRPKQAEDELPAPANEMPEPDVVKPKPLTKAEDELSSFIDEFESPSQIAREIAEEPPRMMLKDAISARLDEAKASVKSPDAPYEPDSSDLDDPDISSEDLLMLELKASKSSPGTSYARLRPDPGPEIGPHRYASNSLPQPNPLPRNSRIMAGPTQMSMQPPSDGASDTQPRSANNIQVKTLQSKSQENPKTKPTSTTLNKSTPPDAQTRDRVPAVNQAPRRVIFVPRNASRQPRSVRHNPPINQPPPEAVNGYTLSELESLIDEDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR2</accession>
    <name>A0A6A7BWR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_271532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWR2"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="36793" checksum="156FF08ACB7AAA1B" modified="2020-06-17" version="1">MRLWAIADIHVSFKSNRDEFAKLESRGPGDGLILAGDVGESLETMNFAFATAKSKFKHVFWVPGNHELYSSRAHVPEEEKALKGEAKYMSCVMAAQAHGVLTPEDDYMTWVYQDEDGNQLAAVICLVFTLYDYSFRPEHVTREAALNWALEEGVRATDETLLFPDPYATRDEWCARLVQQSETKLAKAAATGLPLVIVNHWPLRQDTIFIPKVPRFSLWCGTTKTERWHIDYHAKVVVTGHLHVRRTDWIDGVRFEEVSLGYPRQWQEAKDDGHTVNTLLREILPGPKTPQRGQEPTTTWRGRGRGWSLSHGLEPPQGLAARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWY6</accession>
    <name>A0A6A7BWY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_258589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWY6"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="15">
        <location>
            <begin position="5"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="248"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2859740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="34891" checksum="8D2C610AB206C812" modified="2020-06-17" version="1">MPPRTVTVIGSLNIDFVTRTPRIPQGGETLTATSFTTGYGGKGANQAVACARLADPTHVKVCMVGNVGDDVFGKGYISLLEKEGIDTKGVGVVSCSATGTANIIVEEESGENRILLARGANYPDTRDGLAGRKDLKREEKGIDSSNASPPDLISSETDMAIFQLEIPLETVLHNVTFASERGVHVLFNPAPAVPLPKEVYRHVSTLVVNETEATILAGPLHIDVAAEGLGKVASRFLEIGVKDAVIITLGEKGLIYATKDGENGQMEAEKVKVHDTTAAGDTFVGAYAVLRIGEKLSCREALQKATHASALTVQRLGAMDAIPTRSEVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX59</accession>
    <name>A0A6A7BX59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_295389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX59"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="33077" checksum="EE12B6B5943ECEAA" modified="2020-06-17" version="1">MPHQAAGFVVRMACTFCSTSHAAKLYVELCSQMKLLDEGLSTEVPHDKEGALAGGKTWFWQYLSKECVEELKALHDLGRRGIARAYKEFALFLGRLYNSRVLKYTQILHLLKQMLGTSIPEWYIVESVTTLLSNCGANIHKTQNDKDMIESSLSRMAKASNGHLTGKHKLMIVELFVSHTSGWKEKKNIESDAAMTFAKGAQYEAKELLDAEKRANEGCHTEISEVPNLSTMSSSVMRVRSFPCVESFSQDRSNDLMERLKTDRAVVAVILGISEKRPAGLVLGLIEWLAQVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU2</accession>
    <name>A0A6A7BXU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_78732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXU2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="119" mass="12818" checksum="629B4B3BC94FB662" modified="2020-06-17" version="1">MSIMDRFRTRRLICGAVLWGTLCPITCAAGPAALLLQDETGLSRGKEDTSLAPLSWGSCPVEWEEERRNLEPIVLLHLACAPGRDAVGGDRRSGRRVKEWACVGVSACAGCNPAPFNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXZ8</accession>
    <name>A0A6A7BXZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_258391</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXZ8"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025478846" description="triacylglycerol lipase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2859867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="541" mass="58707" checksum="40742B5D53B5D58D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYB8</accession>
    <name>A0A6A7BYB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_270742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
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    </dbReference>
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        <property type="term" value="F:RNA nuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="194" mass="21805" checksum="00BFA0235733D5DE" modified="2020-06-17" version="1">MHILKTLLSLLFLSLVSAGPVLPLETDDWDFSVNGSWSNMTERAKRPTRYIPTIIENMDEELVQCGNTPITKEAIRAAIEWGSALNENHDGRETDVKGKSTKWPKGYGNSEKFVWINEIKECNGYRLEFPVIEGRLFGDTPDGKDSPGLYRAIFTHKRGKKNRKDGQLVSYYCGTIYHIGRAGEFAGCDVSNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYH3</accession>
    <name>A0A6A7BYH3_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_72859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="159"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="28198" checksum="377041C79E6D004C" modified="2020-06-17" version="1">MPPRKETARQKETVVYPPSKTKSLPYKPPRPAASAFTTAKTALARTESINTTTSASDIFGATIPTSPIEELDDDPLQQAPPATTKPGFTTASAFNKGIIDNRGFKPPSRTTSNGKAKEKVPKDPPTSTSISLISFDNDANDDDSDKDKSLFTPGQDRKRANSSPSIIFQDSPAATGAALPPPNASGTGIPQPLLIRLLHEHFKNKDTKIDKHAIVVLQRYIDVFVREAMARAAVGKEGEMDIWLEKEDLERIAAGLMLDF</sequence>
</entry>
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    <accession>A0A6A7BYQ3</accession>
    <name>A0A6A7BYQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
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        <location>
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        </location>
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    <feature type="active site" evidence="2">
        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="352" mass="38948" checksum="1CC84A94AD7C2665" modified="2020-06-17" version="1">MTVEYESYTLGDFSLKSGGAIPNAHIAYKTFGNPNNPAIIYPTWYSGSISDNEWLIGSNMALNTESYYIIIPALFGNGQSSSPSNAKGDATFPDILFYDNVRAQHQLVTEKLGISHARAVLGWSMGAGQTYQWATQYPDFMDLIIPFCGSAKTSLHNQVFLEGVKSALLTAKGVASDGVGKSGVSNKPWTDEERTAGLKALGRVYAGWGFSQAFYRERLYETMLGFNDLELFMKGFWETWALSKDPDNMLAMLFTWQTGDCSAQEPYNGDFDAAMKAIKAKALVLPGKTDLYFPPEDSAMEVEHMRPGMGKCIVFPSIWGHWAGGPGQSTKDVQWLDSKLRVFLQYGKIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYV0</accession>
    <name>A0A6A7BYV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="250" mass="25804" checksum="FEA6DDB066F1A7C9" modified="2020-06-17" version="1">MSGPSTLPQAATDPPMPEPDQPLQDVRKGRAKGPKKRNAGGALAGVSAAESPAPKEDSLEALKPATEEAPAAISTIPSAEVSRPQAPAGSAGAIMTASLKGPAPTIPRKQVPSQASPTLAPKSPNSSSAKPNPYPATFNEQHKATTLGGDDKENADDERPMVKSPPGIRGPRPLPPSATRSRPQSSSSKDDEATTRPASQASSAPGFWSGLGRLVGKTNDSLSTPPPPPRKSSRVVSGQLQQDKERQDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ19</accession>
    <name>A0A6A7BZ19_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
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    </gene>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32313" checksum="4F604D63880D937A" modified="2020-06-17" version="1">MPHKHTRRHRNDADFDLQPSVKARPLSTFGKQGKPVMKGSRLGKAGKRKRKSGGGYGDDTPKAFIRLMEYSQSGKRPSGLDDGAMLEKKMKIDAAPNVEVPKPLPGEHMGDYSARVDKALPVAGLVRKGKGPQIEGVKERQTRTERRLHKLYDTWREEEARLKEKEEERKELEEEAEDEQRAKYGEGIVASLPARKGKRKRGTDGDEDDPWKMLKEKRPGPKSMHDVVDAPPSFTALPKEKLKMKGNAKVRVDSVPAAAGSLKRREELSRARRETIETYRAMIQRS</sequence>
</entry>
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    <name>A0A6A7BZ83_9PEZI</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48495" checksum="4DDA7DE47E157C76" modified="2020-06-17" version="1">MDDRFPLAASREPNPLRPYHIPPSIGHQPSRPQRELLPELDLNFTSSAAEAWRGSRSLIDNLFYRYTSVLLAQPLDVARIILQVSLPPELTAARTPFERPLRPSAIPTADDSNSDSDSDSESDSSVVAYFASQSRSRSPKKRETLSKTPTPRLSSPASAPREEHTLQLRKADSISQVLSQLYQTSGAIGLWRASNTTFIYTTLSRMTESFLRGFLYAVMSITDIMPSPAALLASDPSGLASGFTGGLLSGADFSASANPMGHLAVLALATGITGVLLSPLDLIRTRLVVTPLSHPPRGLVANIRRLPSLLPSPSLYIPTILAHTLPPLFSACVPLFLTRKFSFKPSTSTLALLMGCANLMVRLPLETILRRAHIAEIKRSEPLVKTIIPPGGYGGVFPTIGTVCREGTRPNGRKGQGVAGLYRGWKVGFWGLMGVWMIGWGASGAGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZV5</accession>
    <name>A0A6A7BZV5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="39979" checksum="09F36131CB8DB9BB" modified="2020-06-17" version="1">MSRTSGGSLSQEESTLSSPASSLSSAALAQEWKNAQEELKISEAVADVLLRSVNDVPDPETPAPPPGRRPRGRPRGASNRGRGNGRGRKRRRVEGSDDEEDSSGEEVITPGVLMTKSGRSVQKPTSFMPQSDGQPRRQRRKRDLNACKNCSRSVSLEGNRIVHCDSCATPYHRYCHYPPIDDSVISGETPQWLCSHCEKNAQQQGQVPGMVSAAPDMTDTKINRLVNASGVPEHMRRHYFSTLPVNTLVDLLTNLSSKRPTLTLFAPHHSRVVFDSLRRQARGTETPDQSILSHNSEYQMRIEQDEIAFQSNPSYGDHPDHYPRPGYGKYFELPPEQEETYLADNDEGVFLHLYREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C054</accession>
    <name>A0A6A7C054_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C054"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="241"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="487" mass="54994" checksum="A497D5BC3620E925" modified="2020-06-17" version="1">MKGPGYLAVAIQPGPDTDPESFHDWYNTEHGPLRLRLPFITTGYRYRAVDGGKPEWIAVYNVSDLSWLESRIYTRLREERSVREKKVMGSFDSLDRKIYQTFLTVGNVKGPAPVQMIETLIIEKSNLDEVRQWLEKEYIPFISDVPGWRRTRCFQTLVGGLEGLPPAHQVEIILVHDFEKDSGLKDVSWTSKPQLIVSRQCREWQHYLTFDSLKEPPSTVITTDGAELKYQLDGNSYDPVVVFVNPILTTYHIWDEITKMLTTTGIGGKRFRVLRYNARGYSQQAERSNPTSFDILADDLEYLLQRLNIAKAYAVVGCSMGGVTSINFAIRHPAMVDRFVACDCNVASSPANNTAWNERVELARREGMEKLADVTVKRWFMEPNHQSANAKKAQVMVTKANFDGFVQNAGALCNYDLKDHLPKIETPGLLLAGECDGKLPEAMQKFGIPNTIFKSVPKAGHLPMMENPEAFEQLLNGFLGGALKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0H7</accession>
    <name>A0A6A7C0H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_257743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0H7"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="121"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="527"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="648" mass="73034" checksum="BA7CF005E7617716" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0J6</accession>
    <name>A0A6A7C0J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_263928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0J6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="21224" checksum="86C02332852D45FF" modified="2020-06-17" version="1">MSCFNRGNIKMQHTWVFWIATPPANPSDLSDRSPEEKMTFNTLYGLNEAVKELIRTAEMGMGEGHYFFKQGAVPVLHHHSNERGGRWTFEFGDRRLTDLSSFIHTMMTIDRVSGLREDDEILGLAIHLDLSRVSLWTRTANCNSTLQVVGAWFNVAMNLERGQTIAFNSNMDIGTIGRNPDRTATKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0L4</accession>
    <name>A0A6A7C0L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_257779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0L4"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27394" checksum="2676928664A57742" modified="2020-06-17" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGAALGILATDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINHARQAAQRYLMTYNTDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPHRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYDEECNLKQACELAVKVLSKTMDSTKLSSEKIEFATVGRTADGTVYHHMWGADEIDALLKEHSLSGVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C105</accession>
    <name>A0A6A7C105_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_257232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C105"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="24175" checksum="4706AEC93110172C" modified="2020-06-17" version="1">MGDPIGRAFVLPRTSSKVEKRRERNWTEKKEGEIGIDKRRLSVGQILKMVAPRGMSFSSKGPGSVLRFDGKDLRIGIVNARWNNDIIDLLLAGAKKALKDAGVKDENIVIQTVPGSYELPLAVTGMANAGKTAGAPFDAIIAIGALIKGHTMHFEYIADAVSHGLMRVQIDTGCPVIFGLLTLLNAAQGMERAGADGGHNHGEDWGYAAVELGSKRRAWGQGKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1V9</accession>
    <name>A0A6A7C1V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_215023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1V9"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="277" mass="31282" checksum="8479BA1D59AFC534" modified="2020-06-17" version="1">MALRPLSSLLCLRAEASLSKRLYRSAPSPSITTKPWLCQGRTFSSTARPQYKTVDEAKSRHRTGPFSWQAGVIFLLAGAGLTIYFRFEKARMERAKIAEANKGIGRPLVGGKFHLVDQNGNDFTEETLKGKYSLVYFGFTHCPDICPEELDKMAGMIDSVKKEHGNVLRPVFISCDPVRDTPEVLRKYLAEFHKDILGMTGTWQEVKDVCKAYRVYFSTPPDVKPGQDYLVDHSIYFYLMDPEGDFVEAIGRNFTSEAAAKVINDHIRDWKGPIDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C246</accession>
    <name>A0A6A7C246_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein translocase SEC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C246"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7774" checksum="9945E596CAA8CBDD" modified="2020-06-17" version="1">MDQTKEIMEMPRHFLKDGRLFLTRCSKPDKREFLRICQAVGTGFLVMGAIGYVVKLIHIPVNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C284</accession>
    <name>A0A6A7C284_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G protein gamma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_192581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C284"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G protein gamma" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="58" mass="6781" checksum="4375F1EADEA290BC" modified="2020-06-17" version="1" fragment="single">KQESMADLKLERLNELKRWLQADLDKPRVPVSEAANALIDWTDQEPVDYMVPSRWGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C293</accession>
    <name>A0A6A7C293_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_270012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C293"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12849" checksum="F0EC6070E2CDD70B" modified="2020-06-17" version="1">MKDTVSVIRKIEDLRDSFQQRFLALVQLAQITDQEKRNHSAIVQFQNVVELGGLIKTGEDTQKMIRQMQEMWLFGRLHPSESGNDQGEKSDEMIAKLGRAMGGEGEGLGSLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2D9</accession>
    <name>A0A6A7C2D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_263828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2D9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="462" mass="52201" checksum="9AB0E1F2642A0D5E" modified="2020-06-17" version="1">MRKIAYHIMRLATMFDVASNAQAETLGLPWAIIRFLFIVISTFVQVAQKEQNEWILKGIETVLDTRYLLNMYIDIYSQLDATPAIGHLLEKAQAGIDQGVKGVQQTLDLSALQAASGAVYNSMDHRHANKIGELQLCLAGTRVEIRRKIVDWATAASDQRVFCYLKKPERADLQLFEPLPMSCNDIAAASHGLPPVNERPLTNQFDKLIKEPLSRYDTGRAMDIRVIVIDALDECEEWGAIGHAMTFWSKLCAHTSINLRVFVTSRSDNKVGDKLKKLEGKDLQHERLEDLQFDELRQLREKSSYTSSYDTLEDDWQGEVVINELVEICQPLFIAAFTIFRDVASNPRQRLQRWVDWLNFTGSDSLTVIYFEILEHAADLDKEWLRWFNKVVKPITLLLSPLTITAMADLLGEEGNMNGPNALISLSSGIYFPCGKGTKAGSRAAVKIYHVSFSDFLLDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W0</accession>
    <name>A0A6A7C2W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_276281</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W0"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
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    <sequence length="402" mass="45023" checksum="85D5CF668D239485" modified="2020-06-17" version="1">MALQRSSKALRAINVASKQAAPRLQTRTFASVVKVCGRRTWTRPAQTALKQQRGMKTVDFAGDKEVVYERADWPRDKLLDYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKDGTSWKEAVQDGWVPGKNLFDVDEAIKKGTIVMNLLSDAAQSETWPRIKPLLTKGKTLYFSHGFSPVFKDQTHVEPPKDIDVILVAPKGSGRTVRTLFKEGRGINSSFAVFQDVTGKAEEKAVALGVAVGSGYLYKTTFQKEVYSDLYGERGCLMGGIHGMFLAQYKVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDYMYAACSTTARRGAIDWSKKFENALRPVFEELYDSVKSGKETQRTMEYASRPDYRQAFEKEMEEIRNMEIWRAGKAVRSLRPENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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    <accession>A0A6A7C383</accession>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="529205at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11175" checksum="13E88EE1C9DD85DB" modified="2020-06-17" version="1">MSTLLPRRTILTLQRSSFSSLTSLRAGKESELHNENRANEADKHKHDQLEKAKSGKNNWSEKLASDSEESVKADRGDMNGSGESVADLQKQSTEKFRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3H7</accession>
    <name>A0A6A7C3H7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_229929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3H7"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="812"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="958" mass="104535" checksum="868E6B3E3E038173" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3L0</accession>
    <name>A0A6A7C3L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase I associated factor, A49-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_256479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3L0"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43914" checksum="C87D393BD78AADB5" modified="2020-06-17" version="1">MSSKESKKRKRDDSQLVAKYTEPPGPHAILLNTPGIVAPTDITFQAYTKKSDRILHTSSHPRLDYTAHPTPDPHLKHYMVLHNPKTLTTQIRPIEKLTLRAHTRKASLPTAITRNPKSQREALGLEFGTKKAQKALLDKSRNAITSTAPQPEILASLDELDPPPNQAEIQLNAKPIPKPNPAATRVEDAYPFGELIPPQVAKQLSTEKWVKSVHGGEEIKFHHRYPAKHVVAVVRSGDDERLLALRYLHLLLSFHDTLTGRMPKKIPKREVLLKKLGEEFSPQAIEGVRNRFAVGGELPKWNFEKLRIWICALALRAEGFVVWTGELRDDLRVSDEEITKFFRELGCKVAAPTLKELGEVGLSKAQGLGMRVARLRVPLVFPKSGGKRRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Q3</accession>
    <name>A0A6A7C3Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_213668</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Q3"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="399" mass="43354" checksum="FC5ACA9278AC2155" modified="2020-06-17" version="1">MPTAGDNFEDSEKSSWLQEQQASRRRTRLICIILLALLILGAIAGGIAGGILAAKEHSKSSSSSTISGSHKSHGLYDSSSPEVKSLLQNPNLHKVFPGMDYTPLGAQYPECLTSPLDQNNITLDLAVLSQLTPTIRLYGTDCLQTEKVLTGISRLNLNSTLKVWAGVWLGNNKTTNDRQVNQLYTILDTYPQEHFAGIIVGNEVLFRKDLSPAALGEQMDNVRQKVKSKGWDLPIATSDLGDEWDAQLAGASDLVMANVHPFFAGVPADQAAAWTWSFWQQHDASLKSGGKSVIAETGWPSEGGTDCGTDNPSSPSPSSTAVGAVADIPSLNTFLSTWVCQSLTNGTQYFWFEAFDEPWKKIFDTPGKKWESKWGLFDEERNLKDGVKIPDCGGKEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3R4</accession>
    <name>A0A6A7C3R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_281206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3R4"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50936" checksum="AC73F5D23D51406A" modified="2020-06-17" version="1">MAVSGPIWMGQSHIKGSTESMRMMLLTFASLGLQFCWGTEMTYGTPYLLSLGMSKSKLSLVWVAGPLSGLVMQPVVGLLSDRCTNRWGRRRPFMMAGTFAVVVCLLILGWTEAIVKYFVGDEERIRSLTVVLAVVDIYILDFMINISQSACRALVTDALPAEKQQLGSAWCSRMAGFGQMLVYGLGAIDLQHIFGPLLGDSQFKQVCATAAIAMLIAQGTTCWAVSERILTSPPSQTPTSNNSITSILKQISHTTLNLPDGIRAICHVQLWSWIGWFPFLFYGSTWVGELYLLSAPTTRSKQAILTETGRHASQAFMLFSILNLLGSIFLPSLLYDPSSSAGLPAKNPIHSKKPTLKQAWRWSNFSFAALMALTPFISSFHLATILIALCAFPWSVAGLAPGTFLGVQVNRLASLPLDDEQGDAAGIYFGILNIYTTIPQFLGTGISWVVFSVVEGAGRECRFLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3U5</accession>
    <name>A0A6A7C3U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_275533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3U5"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
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    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="558" mass="61023" checksum="4FF6B8F9EF901204" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3V2</accession>
    <name>A0A6A7C3V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_281155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2862043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="51626" checksum="7379F5653FB1C2D8" modified="2020-06-17" version="1">MIPWLALASFIWLFRYLRLIINCLSHWTYRSTPPLEKSSYNAHDVTIIMPTISFDLEQIQRTIRSCLAAAQCEIILVGVDANVAFLTGIAQAIGPKVRVLCTHEANKRGQICHAIPQVQTPITIFVDDDVIWPNTIMPWLLAPFHDEQVGGVGTSQRLVRSTRQSVWFFLGAAYLERRNFDCSACLHIDGGLPCLSGRTVAYRSEILQDPAFTYHFTHEEWRTCQLNTDDDNFLTRWLFNHDWKIAMQYHAEAEVQTTLAEGPLYLTQCLRWVRSNWRSNLTSLIVERRCWRTHPWTTYAVLQTTLTAWALPYDLLIAWAWYRAMGAMSLYDAKIVLLVLWFAFSKTVKLWGHFYRYPSDIIFVPVYILFGYFHGVIKFYGLLTLSETKWGSRAEADTDDNVRMIRLPSYQEQDDSHNHRDFAMLEDEETKVSSEELPPYPTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3V7</accession>
    <name>A0A6A7C3V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_299001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3V7"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="199" mass="20478" checksum="E02EE9FD4A2AB41B" modified="2020-06-17" version="1">MGGLTYGSYGTGSALAVVGLYMLFQGQGEAFNVGSFLESVSPFAWASAGIGLCIGLSVVGAAWGIFITGSSILGGGVKAPRIRTKNLISIIFCEVVAIYGVIMSIIFSSKLQPVSADKLYSANNCFTGYALFWSGILVGTCNLVCGVSVGINGSSAALADAADPSMFVKILVIEIFSSVLGLFGLIIGLLLSSQAQEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4F1</accession>
    <name>A0A6A7C4F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_293527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4F1"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="674"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="703" mass="79723" checksum="C10DBD4783617443" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4G1</accession>
    <name>A0A6A7C4G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_256130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4G1"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="35"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="399" mass="43589" checksum="F8AC7DE9E557BBF2" modified="2020-06-17" version="1">MGEAMATLEGKLQEALEKRASQATLRTLSTGKYAVDFSSNDFLSLGSSEALRKKFLEEVQNAPGLGSGGSRLLDGNSAIAEGLEKRIAHFHGAERGLLCNSGFDANVGLFSCLPQVGDVIVYDEHIHASVHDGMRLSRAGERVAFRHNDVDALEEVLQGVAGRGKNVFVAVEALYSMDGDVAPLREMVRTLRKWKDVHLIVDEAHSTGVYGPNGRGLVSELGLEKDITVRLHTFGKALACNGAILLCSSTIRRYLINYARPLIYTTFLSFPNLAAIKASYAFLEEGRTVDAARRLRELTKELHSRLIDLRDGYPAATQLIHVPQERPNSPIFSVRSSEPKALAAYCQTKGIAVRGIVPPTVPPGTERVRICLHAGNTVEQIEFLVKTMGDWLEAARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4H3</accession>
    <name>A0A6A7C4H3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">DNA/RNA polymerase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_206258</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="6736" checksum="62A3276EBE086CB6" modified="2020-06-17" version="1" fragment="single">PLLSAEPDALKSTLNEGISKGLIKPSNAGKAANILFVPKKDNSLRMCIDYRNLNSNTVTNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4W3</accession>
    <name>A0A6A7C4W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255909</name>
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    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4W3"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="95" mass="10343" checksum="E2F434BD3A1776C7" modified="2020-06-17" version="1">MSLGENSNMFRSECTVNCEIADPTFQRAAGAEAGAQTRSPKGEAAARSKKDPRASVKQLTAESQAKLPRKERKTLGVAIGLPWMRVRSGPKRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4W6</accession>
    <name>A0A6A7C4W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_263202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4W6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="24710" checksum="EE19DA1C43B00C6C" modified="2020-06-17" version="1">MPGKKIHPTPAAESALAVFTLEERDFMALAHHFFAKPLEVDMNAFAQMYRRRASNMRTDWEGIQDKIDGQKEAIDDEIKQEQIDAKEKRAAKRAANREMKKKAAEKKVAKAAQAATVKGSAKGNSGVTMVTTTSPSAEGQGAGKKGKKAARGTKRPAETIDEGAQKMMKHNATYTHGIRFAKHAWERLEFMSVITSMKLLQCYFLMRDCSTPPEGDLYDFAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C586</accession>
    <name>A0A6A7C586_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_192826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C586"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="411" mass="47352" checksum="6A25AE01BEDE1BB6" modified="2020-06-17" version="1" fragment="single">MSTRASNARNVRQRKLNPKHGLAIVDESDVEQNGEEESQPQTTVETGVEKAEEIEFHLQAVINASKAAKQSYIPTPDATKAKGIDYDELYPKVFKPPASNIRFSSTVEDCMSSLYCVDDEDVAFIARLRSGKDFEGHDRHDQLGPCSEDVFEEAINFFEQTSAHLQPFANVDNAPILSFGEMEQSAANEDDLSTDAYRWLSLIYPYWVSRKGSRPLMPTIKARMIDGTDMDDADPYVCFRRREVRQTRKTRGRDAQVVDKLKKLRLEFEQARQLVQMVVQREKSNSSNLEVSKKLFRQRMELNRFKRWMKLTAENDEDLLVDQRRAPKPRPRPSTEQHRSSTIRIRTSIDRPSLPSETFSLEELHAETEALMNAQVENQKKQHKAWNDGWIDGTMRPITPPLEREDPFSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I2</accession>
    <name>A0A6A7C5I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_275234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I2"/>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="14716" checksum="89322F6CE9A8E4E0" modified="2020-06-17" version="1">MSHIAALFRRAPAQAPRIQVPFNVFSNPYNCKRSWPPDFEKLSQKHQFRLERRYRRRTKLKWARPTWVKALKLTQWGSVLFVLVYGVLYMDMDTKGEPTPFDGIRRWYREEVVDQRVQGSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5R0</accession>
    <name>A0A6A7C5R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_255632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5R0"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="21826" checksum="BF2FADAD2069A43F" modified="2020-06-17" version="1">MRYIHSEETLDIPEGVKVNIKSRLVTVEGPRGKLTNNLGHLSVSFKQVDKSRLAIELHHGVRKNVAALRTVRTIINNMIIGVTKGFKYKMRFVYAHFPINVGLENNKETGLWEVEIRNFLGEKLVRRVILRPGVEIVASKNVKDQIELSGNSIENVSQSAADIQQICRVRNKDIRKFLDGLYVSEKGHIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Z2</accession>
    <name>A0A6A7C5Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_298367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Z2"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="26526" checksum="F7F4EDDFF60628F8" modified="2020-06-17" version="1">MIPSNRKHQTFFQVNGIVAVITGGRSGLSLYATRALDANGAKAVYIIGRREETLKEGAATGPCKAKGEKPSINDFQDALWQMPAKRVSSIFELNSTATYFTGVASLFPCKLAQESQIIINSSGLTFSREPTLSFLFTMSKVGLNHLVKMLSIALATYDHHIRCNAMAPGLYPNHMSKYTGPPSQDDAFADAYATQSGKFNPSKRMGSERNFAGVFLFMASQAGSYMNGQIITPDGGSLTQIPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6N4</accession>
    <name>A0A6A7C6N4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_212390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6N4"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="38293" checksum="13F74B9431E06F2C" modified="2020-06-17" version="1">MVAARSAHIVSPQDLESLHNQVHQLADGALHLQDDQLPDERRVLYVLEQLQKLATDLMEGRVSSESPKEKSATSALLGSVSTRSYPSFVSRASVLNLISEKAEAILRHPNIFITPSILSSYVNLQSLLHQPTSFPEIFDLYAHKPIAEKTPSGVTYHAASPEKLTSAIDPRVADAALQSAMNAHNLQLALSIISTSYSRVAFKKRQLVRQGLIPLTGLTLAPLAAWTLAQQFSSWQSTMSESQATGIAFAGIMTYVAAVSTMGYVTITTANDQMERVTWAQGVPLWERWIREGERAALDRVASRWGFKDPERRGDEEGEEWEYLREFVGVRGMVLDRVELMEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Q1</accession>
    <name>A0A6A7C6Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative unfolded protein response protein Orm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_211830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Q1"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="21289" checksum="47C8EEE2597D88FA" modified="2020-06-17" version="1">MGQQGKRRRRRSSSLVYQEPPESLEQQSDQATMPNLNAQWVYAKGAWMIHIILICLLKIVYDVVPSISQETSWTLTNTTYMAGSYLMFHWVRGIPFEFNAGAYDNLNLWEQIDNGDQYTPAKKFLTAVPICLFLISTHYTYYNLTYFMINFMATLAVVVPKLPALHRMRLAILNPEPILSDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7B4</accession>
    <name>A0A6A7C7B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_255090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="297"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="500" mass="57685" checksum="8ECC9CA918F796CD" modified="2020-06-17" version="1" fragment="single">MFTPKAQPRIDSKRRAVLDPRKRQFAKAPWVESDYSHRMNFYLIPPTGDVSLEDFEEWAIARLKVLAELEACQFRNKSAAETEEHMRPVLERHMRLSSNMSRSGDRDWERKKDHYSHWTLRLAFSSTAELRQRFARLETQLFRLRLGQDDGRERKAFIDSLSMNWALVDESEKASLVDELKAATGWHRGEEENWFKTEWEKVSDLVERRQCLLKMGQAYVHVREQQGMVVQEFGRQLESALTMSARFLPQLDEDNRVLPILHHLSQSFVAPDAGYNESSSIGDLTVPTAASIDALSVHFPLCMRQLHMELRRNGHLKHFGRLQYTLFLKGIGLSLPECIIFWRKSFRNLTDEKFKSEYLYNVRHAYGDVGGDANRRSKGATPYSCQKLLTEALPSGGQSHGCPYRTHGADNLMALLQSTGVTDKSLLQAVQEDVGKQRYHIACNRVFEHTHKAQLKRVKDQNLWPASELDTILHPNTYFKRAFMLSNLDKFKSGDIGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7H4</accession>
    <name>A0A6A7C7H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_268505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7H4"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="812"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="858" mass="95171" checksum="4778CD42BB70BB26" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Z1</accession>
    <name>A0A6A7C7Z1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7Z1"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002995">
        <property type="entry name" value="PRK03759.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="30102" checksum="4391E79F8DCFCD5B" modified="2020-06-17" version="1">MSSTETVPVETAPPAVQILRMFPEITANRQPSITSDQDLAGYDEEQIRLMDEVCIVLDNDDSPIGTATKKTCHLMDNINKGLLHRAFSCFLFDSKNRLLLQQRAAEKITFPDMWTNTCCSHPLGVASEMGSTLEAAVAGVKRAAQRKLNHELGIDIKRIPLEKFQFLTRIHYKAPSDGKWGEHEIDYILFIKADVDLDINRNEVQDTKYVSEDELRQMFQDESLKFTPWFKLICQKMLFEWWEHLDSLEKYLNETEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8A9</accession>
    <name>A0A6A7C8A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor Tu GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_255324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8A9"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="78"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="507" mass="55449" checksum="6CAB4A1B6C90F72E" modified="2020-06-17" version="1">MFDVGIDDKGDSQLLTEAEWGTALSRLDEALQAAKADKRLLLTRNVPGSTVDVGNDARKVSGCVGKFLLRRKPEVDSAIEVRIAVVGNVDAGKSTLLGVLVKGGLDDGRGKMRVHLFRHKHEIESGRTSSVGMEIMGFDSKGDIITSGVPGRQLSWEEIGKRSTKVISFSDLAGHALYLRTTIFGLLSSEPNYCLLMVAANNGLIGTSKEHLGIALALNVPVMICITKIDICPPHILQETLSQLTKILKSPGALKMPIMIKTREDCINTATQFVSQRICPIFQVSNVTGESLDLVREFLNALPHHGKYDASAPFEFHINDTFSVPFVGTVVSGVVKSGIIHTGDTVLLGPDGLGQFTTTTIRSIQWKRITVPACSAGQSASFALRKVRRRDVRKGMVMFAKMESNPTVHREFVAEVLILSHATTIRTKYQAMLHVGPIRQTCAIVDIDRACIRTGDRATVAFRFIQRPEYLAVGDRILFREGQTKGLGVVTQLGYDFNHPLTKEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8K2</accession>
    <name>A0A6A7C8K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_81519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8K2"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37978" checksum="D99A54DD365EBC1D" modified="2020-06-17" version="1">MLTRHVSRGLRWSSGISRPGGTNPIPKQELPKTPGHPTIRPAHFVFSLLSLSLGLYAAQLYNLVRQPCHNPEIKHLSSQKDVAARYEDTAENFDTEVGISEVLMRINAKRKHLTQRCWGNVLEVSCGTGRNLGYYDVSKGGKVKSLTLVDLSPQMVAVCKRKWLALHGKKKHLDPGFVVRFVTGSALGDMPPPPGGRKYDTILQTMGLCSTAEPVRLLENMVGCLDTENPEARVFLLEHGRSYLPWLNNVLDNAAERHAEVHGCWFNRDIGELVRLAAERTGMEVVRERRFQFGTTWLFELKPKKKGDGSLLEKGGNTLTEKGRSDEQKSGKTSWNGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C944</accession>
    <name>A0A6A7C944_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_274017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C944"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="194" mass="21968" checksum="36F63D4E6FE9AAF6" modified="2020-06-17" version="1">MAPTTKLSRPIVVSGPSGAGKSTLLKRLFNKYPTRYGFSVSHTTRAPRAGEEDGVAYNFVSVPEFEKMIEQGKFIEHARFGNNLYGTSVQAVKDVLEKGRVCVLDIEMEGVKQVKKTDLNARFLFLQPPSVEILEERLRGRGTDKEDAIRERLAQALREMEFASTPGVHDEKIVNDDLEKAWKQFERFCTQEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C946</accession>
    <name>A0A6A7C946_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_298163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1574" mass="173088" checksum="C6774B844D2E93BC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9H5</accession>
    <name>A0A6A7C9H5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9H5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="125" mass="14483" checksum="293EDB56C34FA1C6" modified="2020-06-17" version="1">MGHEWWLFSFGKLDDKVEESRSKFIGDASKSHHAPKHTTREKLTFSYRSIYTFKMRPLEQCKHDDVLAGIKAGKSQRQMTKDVGCSKTRVLKVSKEFSEKEGRLNTQKQGVQRSSTRSPRRNQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9R8</accession>
    <name>A0A6A7C9R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_273637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="45"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="440"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="675"/>
            <end position="737"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="1193"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
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        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
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        <location>
            <begin position="626"/>
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        </location>
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        <location>
            <begin position="722"/>
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        </location>
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        </location>
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            <begin position="1081"/>
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        <location>
            <position position="1700"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2864264.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1732" mass="193113" checksum="F467F7BC02BC18A5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9V0</accession>
    <name>A0A6A7C9V0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="GroES-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="44"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="42063" checksum="2F91A2B1E2CB1011" modified="2020-06-17" version="1">MATLLRSRNALSLRVFAIQSRQMSSYGYEQAQCLSFAKYGEPKEVLKLHRHSISPAHGNLVTIKFLASPINPADINQIQGVYPSKPTFSGSIGSSEPLAVGGNEGLAEVVSVGNKVSKLRCGDWVIMNGPGFGTWRTHAQTTEDKLAPIRNHEGVTPEQVGTVSINPLTAYRMLRDFVPLQQDEWFIQNGANSGVGRAAIQLGKEWGYKSINIVRQRKSEEQMASLREELKTLGADVVVTDEEVQSRDFPKRVEELTGKAPVRLALNCVGGPLVNFMAKMLAPGSHVVTYGAMSKQPVSLPMGLLIFKNITFSGFWVSQWSKLHPEQRQKCIDEVLDLTRAGKFKDTPMQKVKWTGDGKSLIDAVQGTLDGFRDKSIFIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Y5</accession>
    <name>A0A6A7C9Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gpi1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_240466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Y5"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="643" mass="72324" checksum="50C54EA731E854AC" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7CA05</accession>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Ramirez L."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="497"/>
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            <end position="598"/>
        </location>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="711" mass="77882" checksum="1D4DE00C4871124A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA75</accession>
    <name>A0A6A7CA75_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="10250354at2759"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
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    </protein>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="111" mass="11111" checksum="A92F9386D4D9D40E" modified="2020-06-17" version="1">MSSTAAVPKTCCGRDGGCQCAKEATCSCGKKPAMHCNCEKAQTENAAGGARCSCNQRPAGACTCSRSAEENAKPTGSTCACGKRSSDSCNCGGSIGSYSNLETDFTKSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA87</accession>
    <name>A0A6A7CA87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_254085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA87"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110323" checksum="71A67FD0A05217F9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE6</accession>
    <name>A0A6A7CAE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_279654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAE6"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="30020" checksum="CC5244B39964568E" modified="2020-06-17" version="1">MAQDVRTYSANGTWRVSTRKRPILKAQPIEELSKEIGIPIPEMIFGDNYIEIVHKPTGWKLEFNARDALDRVSKTDKGMLQVAVAEEWKKERSHKDEVRTVVKPFDWSYSTDYKGTTISGQAKGSWMPSNQTEHPIRIDLLSRPDPILFFDTVDLYEDELADNGIALFSIKVRVMPERLLLLSRFFLRLDGVVVRIRDTRVYIELGSKTVVREYTAKEEKYKALRDKLGGSTDNVTSILRDGNRLAPLLPTVEQTTDVWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAP7</accession>
    <name>A0A6A7CAP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="20702" checksum="0EF47D9BF8DB5375" modified="2020-06-17" version="1">MLSIARPTPTTVQYTVSTRSSSKTVTGGLILVRVLLALSLPVLLLPEFHEAFVPQHLQKYTAPTAALLDSHTTQIRRILAALTALFVIFRRFYIEESLLVIRGLGVQTTTSSASSWGVSTRFISTQSIQDIFIHEAFRKFEVRYYLCIVVDGETDAVVVFSDILPRREILEQVWRGARACLYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPV4</accession>
    <name>A0A6A7BPV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_238626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006051">
        <property type="protein sequence ID" value="KAF2857304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPV4"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="12545" checksum="780813209C04E8BF" modified="2020-06-17" version="1">MNWWTTGCVYGATSVVLGAFGAHGLKSRVSEPSRIANWGTAAHYQLIHSVALLLAEQAAPRNVWAKSLFAAGMTMFSGSIYLLVLDPARFRPLGPVTPLGGTCLIAGWLALAFGKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPV7</accession>
    <name>A0A6A7BPV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_177128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPV7"/>
    <dbReference type="OrthoDB" id="4779541at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="343" mass="36673" checksum="7070DFAF563305E8" modified="2020-06-17" version="1">MKRLSGALKRNRNEEISPFSPSSDSAYASSDGPSLRDSKRSSEMVPVSSNNDNRNLAMNPSTGEVVDEDTGELVTVTTTTVTTTTTTRPGKKNTTSHGQGAAEQPRVQSVASSRNEPQTPVTTQQQTITAPENQNANFNSQGTSVTPTHGQNFSYPRRQVEGTDQEATKPKGAMANLKAAAMGIHGVGETLRGTINSEMDSRFAGRNPAKAEAARTRNAAVLQRGEQEMASVYHPGGMQNAYPQAQGQMMPTQTNMFPHQGTTMQPQGHIPENPYGPDPTAPQFHGQNTMMPAGNQMMGNQMPMAGQGGMGSIPEQNEYGYAQGQGHGESGLKKLLKRRPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPY7</accession>
    <name>A0A6A7BPY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_223512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPY7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="66" mass="7074" checksum="823555353C827A61" modified="2020-06-17" version="1" fragment="single">AATCGTPMPTPTQPGAVSGCAVYYKVQAGDDCDTIARNLSATAVDVKAWTPTIGDQYWNLWANYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQF7</accession>
    <name>A0A6A7BQF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_253408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006048">
        <property type="protein sequence ID" value="KAF2857352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQF7"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="193"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="373"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="472" mass="52885" checksum="59FCAC9335837E69" modified="2020-06-17" version="1">MPVDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQHQIHQQRLERKHRIETLKYEKLINDGLLLRVEALLKAVESHKFGDADDVVFDCLTEVTHGGSLGDDMPPPPPGTVHGKEEPLSYSHMVGVLVDQVKASVDKTSGDRFEAYKKEIASHRDKIQGLNDSLLKELDKLEKEDKSKITSESIHTGFDSTRLSKPSGAAAVKEQERVPELLNPKEPAGSEADVEDDEDVNASELAKQFAKIKVGDFASSLQFIGKHSDAILKESQSDGLLAEAFMAQSKAKTQKDEDYARQCVHQALLLQYCRQLGKDGVGIFFKRMQDPKHAARKIFLDDVNTTYNRIRTRTAEIEKQADEGSREVERIQLHAFEPNSKIVVTVPPEKPTTDAEREARRFFDAFPPNLQTALVSGDLDKVNDVLGKMAVDEAEIIVEQLSEGGMLNMEKGVIDATTEEGQKRVEEIEAQKKEGELQVEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQH4</accession>
    <name>A0A6A7BQH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQH4"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="48442" checksum="431BE3F2CAB05BB7" modified="2020-06-17" version="1">MAEQEQPARNHTNEMENMQESMGPLDESGATISDDEEEEEIDDAVAEDIRAFKATFKDIDQRYRLISRIGEGTFSTVYKAEDLLYDYYRNDWDIDQDSSKQSHYVAIKKIYVTSSPIRIMNELELLHDLRNSDNVCPLITAFRHQDQVIAVLPFFRHRDFRDYYRDFTIDEMRVYFYNLFTALRSVHEAGIIHRDIKPTNFLYSPSRQHGVLVDFGLAERDGAEYAHCLCCASEHDRLRKVQSSVYLTGASSSAAARPSYPNNDTRPSRRANRAGTRGFRAPEVLLKCTAQSCLIDVWSCGVILLTFLTKRFPFFHSADDIDAFIELCCIFGKQKMKETALLHGQVLQTNIPTLPEKSHGWDKIVLWCTDRDRKTQSLSSEEQEAVGFLSKCLELNPSKRLNADDALHDPFIEACLSGESGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQJ4</accession>
    <name>A0A6A7BQJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_273611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fido"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fic"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FIDO"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="127"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="400" mass="43685" checksum="E64C229DD7A25E4A" modified="2020-06-17" version="1" fragment="single">MATKPDIQPAVDRGEGIATMQPMKIGEGGSRYRDAVDLALELTAKSAAFRSSLPPAMRTGLADLVRAMNCYYSNLIEGHDTHPVDIERALKNDFSADPAKRDLQLEATAHIAVQGWVDGGGLSGRATSVDGLREVHRRFCEHLPPSMLWIEPVEGGERVPVEPGALRNRDVRVGQHIAVSPGAVPRFLEHFAWAYQKRGATDAIVSLAAAHHRFAWIHPFLDGNGRVARLMSHAMLLDALDTGGVWSIARGLGRNVQAYKRHLAACDLPRRNDLDGRGTLSEEELASFTTFFLKTCIDQVNFMESLVQPDRLRIRIRRWAAEEMDRGTLPAKAVQVIDAALYRGELPRGEVESIVGTGERQARRVTAALTGLGVLTADSSRAPLQIAFPAALAGSWMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQS4</accession>
    <name>A0A6A7BQS4_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_279286</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
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            <end position="200"/>
        </location>
    </feature>
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        <location>
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            <end position="260"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
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        <location>
            <begin position="480"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="532"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="584" mass="64493" checksum="5FC274675EAE6B90" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQT9</accession>
    <name>A0A6A7BQT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_296993</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="447"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="898"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1507" mass="168876" checksum="441B0C7B6CFBE197" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQV4</accession>
    <name>A0A6A7BQV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_222928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQV4"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="315" mass="34076" checksum="9D33C8AC634F2DA4" modified="2020-06-17" version="1">MSRAEILKKVHKMVPPMLDKFHKGQLGRVGVIGGSQDYTGAPYFSAMASAKLGCDMSHVICEPEAAQVIKTYSPNLMVHPYMRQKSKLGKDESAETVAQEVTGMLDRLHVVVIGPGLGRDEVMQETCARVIQEARKRGVALVIDADALFLVQNRPELVQGYKECILTPNVVEFARLAKALKVKLGDDEGAECAALAKAFHGVTVIRKGRADYVSDGETTLVCDGEGGLKRSGGQGDTLTGSLATLLAWRKAYLDKLWDHEGDMTAQELLLYSAFGGSAITRECSRLAYKDLGRSMQASDLTGRVHAAFCTVVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQY4</accession>
    <name>A0A6A7BQY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_223631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006052">
        <property type="protein sequence ID" value="KAF2857297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQY4"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="78"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="23339" checksum="FE69A50F0ED27D63" modified="2020-06-17" version="1">MATIGPTLPPHLVAKRKRQQEAQEKAEKKQRIADSESDDDYGPALPSQEDTVKIQAHSEEKEYKELPKTLRDGWMTMPPDQDDLKARMDPSRRRARGFKMTTASDSGSTWNETPAEKRKRLHNEAMGITEDKAERIEKKSEGPRNVNRGPSLMEQHKTKAAEAEDDPSKRGFDREKDMKSGLGNAQRRDLVKRSSGFASKFSGGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRJ0</accession>
    <name>A0A6A7BRJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_291676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRJ0"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="133" mass="16042" checksum="F81EC3AB830773C7" modified="2020-06-17" version="1">MEMFLPPPYKEFEDVHMLQIRAWNGLNAAMEALLKKYKLGYRAVEAPQRWFNPYQGEQNKTLQYFQIRLGNPLVHFAGVMDRDERMVRWLQRTEDHLDYWEMPVEATIYPQKTKEFWREQSKANELSRCAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS22</accession>
    <name>A0A6A7BS22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_222827</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS22"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="492"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2857707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="882" mass="98652" checksum="3CE0A2A7A4CA6A9F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS36</accession>
    <name>A0A6A7BS36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_194975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="19981" checksum="E4E0BF4F6BE48EBC" modified="2020-06-17" version="1" fragment="single">LNPEIANLSPRALASYMLTQTRRFQPDLTTLELEELTLPVERIRDTTAWKDQRVAGKLPDFIRYLSAPPANNSSPHTEKGAPHTLIISSSGLRSADLYRALRGLKGEKVVKLFAKHIKLAEAREVVRRTGFGVGVGTPRRMLDLVRGGELRTNKLERVIVDASFRDQKQKGVLEIRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS84</accession>
    <name>A0A6A7BS84_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">K470DRAFT_151090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
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            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
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    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="599" mass="67130" checksum="2178E9F66EBDEEC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS96</accession>
    <name>A0A6A7BS96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="134" mass="15209" checksum="DC5FEF8A0C005733" modified="2020-06-17" version="1">MVVHDEVGESIRQKPPCEFSLIFNGLKQDSRHYLGIFAVYSVDGKESPMIAFRGFKDESSYGAISHWGTFNEILAEYNRPLNEVLLIIGDNCSTNRKFARDSRIPAKAAQAIGSKSRWTLIWPLLTRNLIRYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025493017" evidence="6">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="41360" checksum="F3A54C200BD4D776" modified="2020-06-17" version="1">MFLSIAFVGIALGLVFGLSPARRSSLGLPLPTHGHQVPINPALDVNFPDPSLWHANGIYMALATNNAAGILNAVSNITGQDDYGVSNVQVATSTDLLSWTLLDARHDPLPRVGKWAVQGLAQETHIPKAAVWAPSVNQRPDGCFVLYYSAHPHALDSSGNVAVEPASIGAHPPPHCIGAAIARDPIGPYSPLDRPLACPINRGGAIDADGFRDSNGDMYVVYKVDGNNIGHGGDCGNTVEPLLPTPIMLQKLLADGVTPDGEPSQILDRVEEDGPLVEAPVIVQSPDGLYFLFFSSGCTRSPSYNVKYATATNVQGPYTRAPIPLLRTGDFGLLAPGSVGIHREPGTNDYNMVFHARVAEDDTGLVRAMFNTKLSFNGHVVTLEPVLSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT19</accession>
    <name>A0A6A7BT19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_283395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT19"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116631" checksum="0CE480C1C0ACFF34" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT35</accession>
    <name>A0A6A7BT35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_266069</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT35"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="147"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="761"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
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        <location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Magnuson J."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        <location>
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            <end position="494"/>
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        <location>
            <begin position="621"/>
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        <location>
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            <end position="301"/>
        </location>
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        <location>
            <begin position="346"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <name evidence="9" type="ORF">K470DRAFT_120021</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
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        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
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        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
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    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="289"/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUC5"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025522852" evidence="10">
        <location>
            <begin position="28"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="510" mass="58953" checksum="4B36244F35DDBEF3" modified="2020-06-17" version="1">MIRRPLIRWALVASVVILLVTWHVNTSGTIHAPEWLPQTMRLGKHEYQTADDYLADFGPILQENPMTVRQTKQACNFNPEDDIDFQFDKGADWVVQDRSDQEIALKQAAWHDFMRHHLIPFERVKNRFSGRGIVVCAGNERSLLRLWVLLRMLNQVRTSLPVEVHYYGDEELSPKNRTDLSAEYKNLYFSDLSGPNAFLKTGHENFWINYNVKLASLLNSRFAEPLLLDSDNTVVSDPETLYNSATYLDYGTVFYPDISRTRPENPMWAITNTPCRTDEYEMESGQLLINKVRFWYHLQLAAHFGHDKYYQDFLLGDKDCFRFAWHALRTPFGQPDRWLTSIGFVARPQRFPKFPNPEGEMIAEVDLHGNEFQGGRNSYYCGHSFGQHYPDGANASVLFVHGGLVKTLSQEEITHVRSQAGRLFAAYKSSERANLVSFFCPFGEGVSADDDRLGGRLSRCILNGIRRESWGFIQRVRIWGGSCRGCWGMRVHRRWWDLRRGLRMRGGFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUT6</accession>
    <name>A0A6A7BUT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_288882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUT6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="38860" checksum="F7466EF09404C97C" modified="2020-06-17" version="1">MTELGVIETLSQAFADVDILDYDESMDVGYSAGINVENQMISRHSHESQEGGPNIEGGHDSDMESDIEDRVTVEEKKKAGSWEDEAYGQDRRGDQDEAEAEAEEGHRDEDRNQPHYSCSPRSAPPGPALIAEPEHEYSPFICEIDALFFAFDVSTHHQLYHRVDEGVLEIARTTPDGTISIPSVSKLKRYKNVVPSPEIQRRVPPEAKSFHQISILDSMRMEACKPGMKLVQYSEILKPAPAFSGEGKVVANQMRHGDKWRMERQLLRPVYCLRLREGHQDVWISDVLELCTGENAMFYGCEIHTTRGQSALVVCAIKLTLARPIAPSSEKARLLLPIKEGALDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVA9</accession>
    <name>A0A6A7BVA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="30"/>
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        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="17458" checksum="EF8741B2738C3BFC" modified="2020-06-17" version="1">MGDKDTSTLQSYVDKAAGMAQSALGAVTGSTADKNAGANKQHEANIKDSASHAGTSAGGFAIGPTGVAKENPDRQEGSWDQTLGSAKEAIGGLVGADGLKQQGTQQRTEGEAKQASGELSDLGAGVSDRVKGTLGGAAAGLTGDREKQLEYQTMHDQGKALQRGTEDAINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF4</accession>
    <name>A0A6A7BVF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_265827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVF4"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="69" mass="7456" checksum="1B3A0FEB8433BB29" modified="2020-06-17" version="1">MSSNTMETPKVGESQQYEGNLGLTDPHKKSEGQLGDNKERTKDSDGSTVRPSEATGRDMSGKKPEDKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW36</accession>
    <name>A0A6A7BW36_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="777" mass="85547" checksum="6FE362AC49EA91C4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW86</accession>
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    <reference evidence="2" key="1">
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                <person name="Park H.-J."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="26998" checksum="DDC53E1A0349CDE3" modified="2020-06-17" version="1">MSAFTETNRQAFNALAETYRSQAWQVALSHQVSEALRSRREWLGVDWVNDASKSPVRLLDYACGAGAITDALGSWVSEIRGIDLSERMVDAYNRAAQSAGLSTDCAQAVVGDLISDAQPGPELQGKEFWNFDVAAVGLGFHHFEDPPRALARLSARLKPKSGVLIIVDFLPFDISPDQKGMVMGQEMDKTIKHSGFTEGDMKTLFEKAGLKDFKFSVVKEQAVLEMEDGTHRRTIFIARGRKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWB2</accession>
    <name>A0A6A7BWB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
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        <name evidence="13" type="ORF">K470DRAFT_271378</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="19581" checksum="31EF957F53300C11" modified="2020-06-17" version="1">MAARSVALKLDWAALPSKLGLKGSTAQALQTFKKRNDDARRRVQQLSQQEQTIDFAHYRSILKNQDVVAEMEKQVNGFAPKKYDVSRQIKAIESFEAQAVKSAEETKFKVDAELVDLEKTLKNIESARPFEDLTVEEVVAARPEIDERVSQLVSKGRWQVPGYKEKFGDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWI0</accession>
    <name>A0A6A7BWI0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="91" mass="10124" checksum="97CA470EF5C125AD" modified="2020-06-17" version="1">MYSGKDPLQFFAEFQRVVRDCKASRCELDNSERAAETARSVANVETIHLLVQKERSATGQVSVHHDATVMDRQGPASLLGLPQERNETHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWI5</accession>
    <name>A0A6A7BWI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_272121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="435" mass="48262" checksum="37AA024669762FC7" modified="2020-06-17" version="1">MDNDGFRRLFTETQDQIGGGGGPKNRGFLGRATKMNQATEAFAPRSVQPKRSVQTKAAQPKGTKLAKGYTDRAAARQRETSPEPEAGEEVEGGSLATTHLVKGLDWKLLERVKRGEDVYSNTKDDEVSKDDELDAELDALAEKEVERAPTSGKPQGKRTRDEILAELKASRQGELNEKWRKVTGRNPPVQVDKKGREVRYVTMKDGRVKKVVRKVKPQADSVMDDMSKAEEGDRGTSLGEEPPGEAVQADAKGGDEDPMQTHPTTNDKGSSNPNAKIVDKDGSAEPPSPDKVDDDDDDDDDEDIFTDKGRDYNPLSSPSSPANSEGGRAVKVPNPKELFSEPKPSERAPKANLPKNIFPDRKAENKPPLPIPIPLPVPRPSNPEREQEDDTLKRRQEKLQQHLRESERDNIDVYGEDHVSKSEGESSKRRKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWI7</accession>
    <name>A0A6A7BWI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
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        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWI7"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025709962" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="539" mass="59160" checksum="D33BB97867A2EF20" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX35</accession>
    <name>A0A6A7BX35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_93413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX35"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="22098" checksum="98B2A313BA7457A5" modified="2020-06-17" version="1">MFIQRAQTLQLLVPLVPPLRQCTSYKHWERILRRHHKTATKILWLKPSKESRRRRSNASDVWHCSRCAPPPTLSMTGPWCVPSSKNFFACLNVSLFCGEGPATGGGNRTPSPLRGGAPRLDKVTWSANDGNFTSTDRTSPRAAPPLLPLFHHQIVPSKPCNRPRRSCAAAGIPHCPFWDARGRHHNRAGLLPHPLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX93</accession>
    <name>A0A6A7BX93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX93"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22246" checksum="7404D9F33D2A8352" modified="2020-06-17" version="1">MPPRKSTKKSQTRSSHASETSTQESEFREAFQLFSTKPKTREKRYLNNDGEAYLPLTDFRRALSALNFPLPDTKSREWREILSAVNPDEDEEDQRKGIDFETFVGVAELLARRQDDGAADAENEEIESVYHMFTKNRPGAKGISLQDLKHVVGLLKLEDQVDEALLRDMIREAKGGEEGEVSLDEFGDVVRRAGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXG8</accession>
    <name>A0A6A7BXG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_258429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXG8"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="241" mass="26845" checksum="FD10BD284CDB715A" modified="2020-06-17" version="1">MAGHKYSVLLPTYNERRNLPIIVYLLADTFRKNGLDWEIVIVDDASPDGTQDVAKQLMKAYNTDAEHIQLRPRAGKLGLGTAYVHGLQYVTGDFVVIMDADFSHHPKFLPRMIELQQKGDYDIVTGTRYAGDGGVSGWDLKRKMVSRGANLVADTVLRPGVSDLTGSFRLYKKDVLARVIAKTESKGYSFQMELMVRAKAMGFRVAEVPISFVDRLYGDSKLGGDEIVGYLKGVMNCFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXV4_9PEZI</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2860051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="15118" checksum="6F3C19BDC944A1DF" modified="2020-06-17" version="1">MGIKTWAQVAAVANREYKFPAKLTRQLTVNCTDTADDMKNRSEVDILAAVNSWKAIRGVRAVRKLPSGDVNVVFEEIKWETYNSDKSWVTKAFGAGKSLKKRSFAVLVKGVDPGSEILMVPSPLRQWDASQEQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859525.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="989" mass="112248" checksum="86F6C51713954B83" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY25</accession>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
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    <dbReference type="Gene3D" id="2.120.10.70">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2860003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36896" checksum="CAFA90FE2187F130" modified="2020-06-17" version="1">MGGSGIGFASMPFGGIMKNSSQTLANIYYQADNNIDIQVRQLLSNGSWTYKKLPVQYDARLRTPLDAVATVDNNGIVTWNTFMVNYANRPYHHVYQDGGESGWGIIIDVAGYDTLKPPGVYTEGSTPIRACTFHYGEKMSDQSRYNTDGIMVWYASNETLFEEWTYKNYTWEHSKQWSVPSVQAGVGCYSDPADSLAHVMFISSKSAFEFWSIDKNADKPKWRKCPFNALMSAGERFLHNDGEVFYLVDGQNRVLAREVKDAWVCEKEKVVGEPVVIGTALTGTRLGAASVRDGGNGNGMDKGPVVLFQGADGSMLGFERGNGTWDGGVDVLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY54</accession>
    <name>A0A6A7BY54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclopentanone 1,2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_271360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY54"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="561" mass="63696" checksum="3840010A5AA81A8F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYF3</accession>
    <name>A0A6A7BYF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_295572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYF3"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF56">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="371" mass="42565" checksum="E119FAEA098912FE" modified="2020-06-17" version="1">MAINFAEHLRGRLRQGTHGQPPTSGPQTRRSSTSTTRWPDHEPYSTFESKVRALTESIGHFQSVGVQHHNGGSYKRVVVAHMRVGNRIADGIYRISRWGEKPGSPERETFLADEVRDEVAILQLLAKLEIPAPHLLAFDASRGNPLNCRYTLLEFSSGICLEDIFDNMTLPAKLNVVDGVVGFLVAMERVMYPRTGALCAHKQPNMFTKASRFLGGSMPQFKIDIQPFWTLREDETLDTLADLIPKLIRSNIDQEEDVTRKRQLDTVLKICIEMEEHEIFKFQYPEVVSTSSGILYHWDLFPRNIMVAQSGPRQEWKIDMVIDWDYLEAVPAVLTRRPPYWLWDRTEEDKMTHVRSDFVVDTDVDLLDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYT5</accession>
    <name>A0A6A7BYT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_276999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11627">
        <property type="entry name" value="HR1_Ste20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
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</entry>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Lutzoni F."/>
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        </source>
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        </source>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="404" mass="44257" checksum="56C19681C80CB2F7" modified="2020-06-17" version="1">MTLTAIKSPRHVSGISDLRTVAGQQVIGSVLKNFYCKDTLQDAGHLFDVIDEPIPARCSLNLYSQMTSNPLRFDSTIEVLDIAAPSVDMLFREVDWNTSTVNELDSILMSPKSLDDGNLSTFFCPLTPFTRGLMRTGGTFIDTRNSSLATNDDEGVIKEPWLRFPRPSTSSSSTTFFVCGGTIPSKSAPEFGNLSTGSSDLESYFSAETHLPRKSPASSVCSRSSSISNLSRFSDILTDYEALLSDTDSVETPPHEILTFGDRLHSSVSSPASESTIPASSGVGTSFLEWMEEAQNEPTPYADLNEQTLEASTQSVLATISNDKPQSSLADEDPNLDVAEVVQPGMVNTIEGFPYDMGAVQAPAPKEEKVKATGRLENRLRHPRQMVRRGLVKLRQRIDWRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZK7</accession>
    <name>A0A6A7BZK7_9PEZI</name>
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        <submittedName>
            <fullName evidence="15">DEAD-domain-containing protein</fullName>
        </submittedName>
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    <organism evidence="15 16">
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C068"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="15988" checksum="EE7821578CA4D8A7" modified="2020-06-17" version="1">MLSALVAGTFAENGKRSSPLCDGKSYGLRVPYDGAILKQNTTNGMCNEFDMVYCSSQGGNTETLFVDIWMSEHKNGSCAITGQVITRDARPDDNGNGNSYTFKAKVCPSADGYPKGDRVITAYEIHTGWQNPNGVLLSRIDVNMETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0M1</accession>
    <name>A0A6A7C0M1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_270115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0M1"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025394778" description="Glutathione hydrolase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="429"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="481"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="600" mass="64763" checksum="3C4915245B82C703" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0V1</accession>
    <name>A0A6A7C0V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">K470DRAFT_257101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0V1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="25454" checksum="9164D0B8454CD8A7" modified="2020-06-17" version="1">MAVRASFENSNEVGVFCTLTNSYALTALGASEAFYSVLESELRDVVPICRCTVAGTRIVGRLTAGNRKGLLVPTSTTDQELQHLRNSLPDAVHVQRIEERLSALGNVIATNDHVALLHPDIERETEEIIADALGVEVFRQTIADNVLVGSYMALSNRGGLVHPKTTIADQDELSSLLQLPLVAGSVNRGSAVVGAGMVVNDWMAVTGLDTTATELSVVESVFKLGEGPTKETVVESFY</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR12911">
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2860857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="427" mass="47609" checksum="6484BFFEA4129FB1" modified="2020-06-17" version="1">MSPRNRANTYRRATRASAWDDSEYVLDILPYTTPAKPRGNIRRTRLSPVPGLVREPSPARASIGRAIKREPDNSPGKSSSNLEDSSISFNSASFVQGTPQYRATVQPPESPLSIWGIIKLVVAFIFVVFALLHLTLYPSLSSPNWASPSKKVHVPYAGHIDWSKIRERTLWTSPRYHESNSDCITAVLAGKLVNERLSGVRSEFKKELKLSDLAESAGVTLDRAEKLSGNPTFHNQFRALTERNFFSPALGAHVDIGKTSRPLDTIRPIAALQRWDEPGECWCAQHTKNSGTMIQLSIILGVKIHPEEVIVEHIPATAAMNPLSAPRHLEFWVETTPEMTEEIDDAADARMALEDVQKCISQPPTPLHVCAGTGFYNINAYNWVQRFPLHLDRDVAPSGFSKIVVRATTNWGAPHTCFYRLRMKGIV</sequence>
</entry>
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    <name>A0A6A7C0X3_9PEZI</name>
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        </submittedName>
    </protein>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lutzoni F."/>
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            <begin position="540"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861124.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="556" mass="61370" checksum="AFBF96995EAF2F50" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C179</accession>
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            <fullName evidence="2">SUI1 domain-containing protein</fullName>
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    <reference evidence="3" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="557"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="647" mass="71491" checksum="EBEADCDD7BEF49AF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1K1</accession>
    <name>A0A6A7C1K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
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        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="449" mass="51138" checksum="6C48E775B5D183FF" modified="2020-06-17" version="1">MSSQSVNCHPMWLVSWWVDRRQARFGPLASLRAAPVNRLQGKIHAPDYLVKSQEATSGMYKTSHPDEADRNNERNEYIPSFIAKKPFYVDDATQSQDDYLEHQRLQSQKNHDPIATSAWYQRGVSTGTKATKFRKGACENCGAMGHKEKDCLQRKRKRGARWTGRDIAEDREAQNVNLGWNAKRDRWNGFEASDYQDIVGGLNVANEEEAGDKYEANDTDVGRQKAAASTRALRLREDTAKYLLNLDADGEDYDPKTRSMADKPANESLADEGFQRESGDAAEFERAQRYAWETQKRDDADTIHLQANPTEAQIKRKRKADEDLRKAAEKKKALIDKYGDQSAVRAKPTAIPASNDVFVEYDEHGRIKGQKEAVQKSMYPQDVLINNHTAVWGSWWKDFKWGYKCCHSIVKNSFCTGETGKLALAEAEEFSRLDRALGDEDDQEERKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T8</accession>
    <name>A0A6A7C1T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1T8"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="26806" checksum="25BFDA4517E4EB70" modified="2020-06-17" version="1">MLQRTLFRARPLPFPSSIRCTRPIYPSPVLTQRLGRFYSESKSESAAEGEAAAAAATEASPKDTPTSSTTSPPKEPPADLAKQLEAKETQIRTLDDRLKRSVADYRNLQTQTKREIQSARDFALQKFAKDLVDTVDNLDLALATVPESKLNSTSDPPSKDLKNLHSGIKMTADVLLQTLKRHGVEKYDPAAKGEKFDPNVMEATFQAPQEGKEDGTVFYTQQTGFRLNGRVLRAAKVGVVKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C290</accession>
    <name>A0A6A7C290_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_276136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C290"/>
    <dbReference type="OrthoDB" id="3905262at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="159" mass="17042" checksum="2C24F4710CA80E4D" modified="2020-06-17" version="1" fragment="single">DLFYDYYTQEPVHGQGSTVTLTDVAYDTIPLYYRGGSIIPQRIESANTTKALRTKDFELIIALSANGTASGNLYLDDGVSIEQAATSDIKFEYSDRTLKVSGTFAYKTDSVIAGVTVLGGSGTSGGYGGQHSYTGYRGKPQGQVIKQKIPLTGPTTIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2E9</accession>
    <name>A0A6A7C2E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2E9"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9076" checksum="2FB0FADA16F12FDC" modified="2020-06-17" version="1">MADSQPADGFRESDFVPDAEKGQQREAIEQFELDRGQPTQEDTELEQLRNEFPSVDGSLIAALYGDHQNAAAVREVLNAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2L7</accession>
    <name>A0A6A7C2L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_215668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2L7"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="486" mass="56629" checksum="C6AC18F11B256431" modified="2020-06-17" version="1">MDEADAGLGESLLKWVNSFEKVEGWEQLSDGRCLWRTLRHVDPEYFAAALPEPDVGPGGDWTRKWQNLKHVERRLSTYHRDVCHEQPLPASFVPDLQAIASRADAGELQKLIMAVIRSAMASPQSNQSMSQRLMGLGREHAMAVANRLRVMEEPLEQDLAQAYRDPLLEREEELFQAQATISQLQDRHEAARRQLHELRQDKERLQEAFETYRSEMQNGKFDDPLRKLQRQAENDRAYIEDLEQQMQTSRQTIAAYEKQLERNRSGDSVCTLRNEIQQLRAENAQLEHTAKANENLKKKIHALQEQEKGHAAVREELGQARERLEELQQLKQAQAGLEKEIIEKRNLIRNQEYQINELTTTRKHAEHEARLLAQKLEAARERLERDQETSLDGDEDKAALERELESTEARLKRITLQNAQLEERLRQQEEKPPAEGATETDATALQRENRLMATAWYELARKVNNQQISTRRKEPRSWIRQQRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3R1</accession>
    <name>A0A6A7C3R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_202933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3R1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="80" mass="8965" checksum="8FE02E4885448D0B" modified="2020-06-17" version="1" fragment="single">FVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGLIEPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C407</accession>
    <name>A0A6A7C407_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_214044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C407"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="21397" checksum="FEE3AC9E6A9EA07A" modified="2020-06-17" version="1">MSPAQTCSLALHSDRSSLQATLSALLHVIFFHRVMAPLRPVHHHVLDLITLPRVPDEAIERTISGKSAELFGHLAGNSMSAKTTVILQFLDDSRASSAAPLQKRSRGGWFSSPQQDTHPTAEIEPEVWESWAIDISLLPAARDEGDKHRVRKAMEDSLINAALQVGEFAGTARPPPGHSAEGMRGYRILVYPRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4H8</accession>
    <name>A0A6A7C4H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_243438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4H8"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="305" mass="33885" checksum="076449B7D75B0534" modified="2020-06-17" version="1">MAGTLKPERKIELFSGTYFGACTLGGIIACGPTHTSVTPLDLVKCRRQVDPKLYTSNVQAWRKIAATEGFRGIFTGWSPTFIGYSFQGAGKYGFYEIFKYYYGEKLFPNVPKTIVYLGASASAEFLADIALCPFEAIKVRMQTQIPAYSRTLREGWHKVVSTEGYAGLYKGLYPLWGRQIPYTMVKFASFEKAVEMIYHYLGKPKESYNSLQQTGVSFLGGYIAGIGCATVSHPADVLVSKLNSDRKAGEGAWQATRRIYGNIGFMGLWNGLPVRIFMIGTLTAFQWLIYDSFKVYLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4W8</accession>
    <name>A0A6A7C4W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_255809</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4W8"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="408"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="744" mass="79450" checksum="7F211F9FBFF3E05D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Z9</accession>
    <name>A0A6A7C4Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Z9"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="72"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="469" mass="50621" checksum="8AB37D70A0A70A10" modified="2020-06-17" version="1">MSNRAVVRVLRPVRALARPSLAHANGTTFHCATPLRLCRRAVVQRRAQSTVSDYVKPAPTLYTAENPGKTALYDLHLRYGAKMVPFGGYTMPVQYSDLPVGDSHVWTREKASIFDVGHMVQYHLEGPGAEAFLELITPSGVQGLKVGQNTLSALLHPKTGGIEDDCIITRLEGGSNPRFYIVLNAGCRAKDYNYLVAALNEWHNGGNAGVQLQHLEANGEPFGLIALQGPLSHEILGSLLSKECKVDLNTWYFGFVKHITLALPTGESLPIVATRGGYTGEDGFELSIHPSQTVAVTEALLAQGGKDRVRLAGLGARDSLRLEAGMCLYGNDIDDSITLVEAALAWIIPKSRRGVGAKFYGHETILSQLTPKSKGGQGVTRRRCGLVVQGAPAREGAQIVDSSGETVGNVTSGCPSPSLRKNIAMAYVRDGLHKAGTELEVVVRGRRRPAIVTKMPFVPAKYVKEKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5E3</accession>
    <name>A0A6A7C5E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_293732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1948" mass="217903" checksum="A6BC5714B2F14205" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5F8</accession>
    <name>A0A6A7C5F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_243841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F8"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="455" mass="50991" checksum="573288BC72E03DE4" modified="2020-06-17" version="1">MKFGHEYQTTLSTEPFPQTWLNSAIDYKRLKKCIKKVQQEVDSLGLNGSEASLFAEQTDEPQIRVLVDRKTGVPLDAALAVEIRGGREKEAAKAAAKAADAEADAAETIAPDAPANPDPPAAATTGEAEPQDPDGSEEGKWILMPLHSARSFFSSLSPKISQLRALRHAEKDRLANEILELSAAVEDIIEPVREGYEAKRSVSYRDLYFWREMFRIYTDEDVFYPLRGPRGPSTTSKGSGGSMIPFSFTDSKSRLADFDTKLRTVGFYSKLRTPAAKLATQKFLDLNLEILKYMHFQEVNIRATRKILKKFTKRTNLVVPRQVFIKDGLVASIARDLYAELASKVLSITPQPQDWMCPVCGKLAWKPVRLGCCDKRFCVGCVVELQAKGRSHCVVCDAESVMKANGRNIDFEALEFMLKYFRLEVRKREKEFEGADEGRSSAVVEHHDEHKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5K0</accession>
    <name>A0A6A7C5K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_268860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5K0"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="314" mass="36125" checksum="EDBB83A933CC470E" modified="2020-06-17" version="1">MSPAITDDTFNTSRDGQALEEVSDAIDTVNVLKANLYSDEAPKFAHGKTASEFRQYEDACSRVKNFYQDQHTNQTYAYNVAARKAFHSRVRARMTIWQAMEKLNTLIDESDPDTDLSQIEHLLQSAEAIRRDGKPRWFQLTGLIHDLGKLLYFFDAQGQWDVVGDTFPVGCAFDEDSIIYPGSFENNPDMKHEVYSTKYGVYAPGCGMDEVLLSWGHDEYLYNVCKEQSTLPEEALGIIRYHSFYPWHTAGGYGWMMNEKDEKILKAVKAFNPYDLYSKADGLPDVQELKAYYMDLINEFFPPREGETERILEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Q3</accession>
    <name>A0A6A7C5Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_293110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3799220at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="5">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="355"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="895"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1508" mass="168113" checksum="2C34D07BD9B7CD65" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C667</accession>
    <name>A0A6A7C667_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C667"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="334" mass="37803" checksum="948FD53891051A43" modified="2020-06-17" version="1">MESQDRMLPFVFQHLDYQMSLRQPKQPLFAEYMPPRRGFFARHEDDEFEDNADYGEDDLSDHDSFADEDQYSEQEDHDASEGYGAQPGKGDQVQHAEQVQSVLTAMHGVLTYNKCRTTVNGVIETRLTSSAITQLFNQLSKISDTDTETHLYLETQLLAIFTILIINTPALADEFFAANILRRLRQLKVYNDSFVPGLAGMIVLLKYLAISSRKYMERILDSGIVHVVWNVALRDAGLQIASARDLIRIGTASSIRSFLECRYVQVEELHFSVPLLAEILRYDNADFLYDACVATNDFCRTDHRLALVCKTTIPGLLSGCYSTPSPLSCSMRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C688</accession>
    <name>A0A6A7C688_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_212619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C688"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="274" mass="30620" checksum="FFE341BDB69BFD66" modified="2020-06-17" version="1">MIPVQLLRPPVPVRAFYRPSRPFVHRQRLPLRFAPPTRSIFIQTEDTPNADALKFVPNHQILSDDFPSSFLEYLSPRSTLAAPHPSPLAAKLLNVDGVTGVFYGKNYITVTKDSATPWAHVKPEVFSLISEAVTNGQPIVNTIRGESSDQGASEDKVSYAPEDEEVVGMIQELLETRIRPAIQEDGGDIEFRGFHNGQVQLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVTGVQQVMDEEEEVAMREFAKFEEKLRRTKGDVPPTASIDKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6A0</accession>
    <name>A0A6A7C6A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6A0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="67" mass="7762" checksum="C2095876397D3BCD" modified="2020-06-17" version="1">MPSDTFEYPSGLWIRSIKTSCEACWIQASPLARMQGTCITSQRYLLHYQLHPRFFPHRGFPSGSCHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6D9</accession>
    <name>A0A6A7C6D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_212339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6D9"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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</entry>
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                <person name="Bloem J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="176" mass="19570" checksum="D5C55EDF2E7BDD81" modified="2020-06-17" version="1" fragment="single">MTAPVPKNSIPSLSVPPTRTTAPVLEFNCLYTHDIRRKSKRWQDGFLRYHTFNKRVMVYDVSRNYIGDCHWSDEHDVAEGDELTLDDPPVLVEVMEAKGKTETDLTDLRAAVRKTPVRPIAACPDTVRSSTVAPLKARSLPSVAPAKHKSLDALLGVRRGPTGKAVLPINSPFEDR</sequence>
</entry>
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                <person name="Bloem J."/>
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        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
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                <person name="Castanera R."/>
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    </evidence>
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</entry>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="1"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864137.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="88410" checksum="DC84F05F18EF9B34" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CAB9_9PEZI</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="296" mass="32208" checksum="EE0CFAB2DBEEB06E" modified="2020-06-17" version="1">MHSQPQPTRAHAGSVANAAAALVGSPAAIHQTIHETTAKRVKTVDYLRRLHQGDVFHFKTLHFSTASIQHLPSCQPHKLGRRATNYFFLGYSLPLLLDLYPTSPLEYLKALAALLHEFDSYQTITGSDGSSGSLSRAKVGLMLKSHIGLANRSGIRTSRRVSAATTESVGTLDSSRSHATSPPSENSLFWQDVAQPPSLGLDFQYLLTPPLPFDPDFNTTFSTFCLVLEESYSHLLSLLADPDSCTPAVGEAYAKADKAVRKILIQPLVREIEENTRQGIKTEFANLGKLVIGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAL3</accession>
    <name>A0A6A7CAL3_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5393981at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="24522" checksum="523B81A9AC3F95D6" modified="2020-06-17" version="1">MKRHCLTARIDISQSPMMSASFSKITGDALSGRKRDHMPLRPKGEGRGLMVSGFVTPGGPLEVPAIISDEALRELGIQRTSDKFIPAAKGSYGDGTSMGQHVAKVKQMFPFVFGHRKYELLWIFDNATNHIGIAKDALAADKMNLGPGGKQPVMRDDWNPVTNAPQPINYPDKSNPQEIESFLTLLANSVSAGRLPNIERDRAQGFERFYRDYLADSPSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAM6</accession>
    <name>A0A6A7CAM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_206394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28481" checksum="17C591800FF16E8F" modified="2020-06-17" version="1" fragment="single">MRYDGHDERYSYSLHIAQQPLRARMCGYGDKDRRSVTPPPCIQVKINDLRTGLPVNPAEVDGNLFVLMVDLFDETGSNKTNVVQTSGHAASSSHPALSATAPYDYGNGHQPRRLSAARNHPYNPAHTRIAPAATSSYSYSYTAPNAAPTNLFTKNLLGTLTVCANKLRALDGQEGFWFVLQDLSIRTEGTYRLKASFIDLGGPDGILNTGRSPILAWCYSDVLRVYSAKKFPGVIESTALSRCFAEQGVKIPIRKENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAR4</accession>
    <name>A0A6A7CAR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_207666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAR4"/>
    <dbReference type="OrthoDB" id="3913595at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="46388" checksum="2B08C692A16314C3" modified="2020-06-17" version="1" fragment="single">SPTARLLQHSRLFALPRPLPAPSVEALTQAVPQSDTATLPYPTHQAIATQPASRSRGDWGLKRPLPSKANASTSHVRIYAQDTRQHVTDFGSAADHTETQAKWRQMGVPFLAQKTRSMDQSRQHWSAFDSEVDNTEASDGATVQRWKYDGPWLGGMQAGEFDEFITDLTVKRMDEWRDFVALHMVEQHIQKAKEAARADGREIGPQQESRLREEARPNEESLMAYEQQLRKGFQTDGLSSELTKLIARYLDLPSVAVDVESVNQDAMGSQLYKILGDIASDTSSIAPQSTHPSAGMLYTRTNAVMENHPVHGPQLYPSPVEARVLRPRQMAQGPSYQASLGVGGVVTSDSVSAATSNARDRSGKPDPAAATDPDLPGGNKVWVHPLTATINHSGRIKLNVVRADKEAVAVKTGDVELIHEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB29</accession>
    <name>A0A6A7CB29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB29"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="364" mass="41302" checksum="075F6553984A7120" modified="2020-06-17" version="1">MGFIRVVLRRADPARHSLTRAAHCGVAGSIDVLVIAAWGNLPFPRKPISFLAFCTMARYKDDKVDQLTNFIIKQIGKHQQHRARLGWPPKPFIIGVNGVQGAGKSTLVSKLAHTLDTRYRYSTLVLSIDDLYLPHDAQVELAKAHPHNTLLQHRGQPGTHDVALGARILDAIERRERNVKIPRYDKSAFGGAGDRLPESRWETVNDHDTRLVDVVFLEGWCVGFRALCEVDLEAKWLEARKEFAEQGITYNGQLGRVDLNSLLQINRYLAKYDVLTDRLKTFIHLDARDTQYVYAWRKEQEASLRLTTGSGMTDNQVVQFVNGYYPAYELYLDNLRQGGVVRGCRNQITFTLGADRKAQHVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBI1</accession>
    <name>A0A6A7CBI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBI1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20060" checksum="DDA876DD21FDEC70" modified="2020-06-17" version="1">MLERAAAGIGKAECIDDVTEYGILRRLVDVYNAAGMTEQAAHVTGRLWAMDKEVNPSDVDLTSLHLASNLGKFYCRMCQWAKAKLVLEETLRRLEEMSNVEAEAECYIHMNELETEKDKEWRRAEARTEIRERLVLKQLTLQHLHAVLKGQGQEPRAMPYCMSQGMTITGEKSKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBS7</accession>
    <name>A0A6A7CBS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_6356</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="MU005957">
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        </source>
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    <sequence length="1357" mass="147926" checksum="793C8314CD0458F6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP19</accession>
    <name>A0A6A7BP19_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">K470DRAFT_261095</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
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        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
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        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857131.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="257" mass="28558" checksum="729516336509B84B" modified="2020-06-17" version="1">MAVQLNFNLRTSANCKTVHLLGSWDNYTRQLPLSKDSSKSGAWNGAFRFYNSLKPGQRYWYYYIIDGYHVSHDPARPSVQEQTTGRKLNILDIPSSPSSDASKRSSRHSRRPSTQPMSGRSLSPSQIKCPRPVRPTETRRVRGEAFGPGAVDKLSRQFARSRIESESDSDSDSDEDSDVPSLTSRSSRSSRSSVPSVSSSSESGCSCNRYGITRSGHRVKLDCGGKQCGSYDSSSGSECSSDSEPERYPTRRYVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP66</accession>
    <name>A0A6A7BP66_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">K470DRAFT_279501</name>
    </gene>
    <organism evidence="12 13">
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP66"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="179" mass="20033" checksum="5B7C5280092EB694" modified="2020-06-17" version="1">MLRTSFARAPSIIRGPVPVVGRRNAHAISNPTLANIEKRWEGMPPQEQAELWMALRDRMKVDWHELTTQEKRAAYWIAFGPHGPRALPPPNEGRKIILYVTGGLLVSGALFSLTRYSMGGASPATMSKEWQEKSNEYMKENKIEPITGVPSDDYKGAGMVQNVFGLKEPKPQTDEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPF4</accession>
    <name>A0A6A7BPF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_261035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006058">
        <property type="protein sequence ID" value="KAF2857213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPF4"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="62351" checksum="E98A857CAEB001BD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ89</accession>
    <name>A0A6A7BQ89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_253256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ89"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="276" mass="31027" checksum="80D369733400B95F" modified="2020-06-17" version="1">MSQFKVPEADIYYETYGSGDPVLICVSGANGSCEFWRDMAKALTNGGKGTVILYDRRGFARSGLTAAQDYAHRLDVDADDVQRLAKHVSPHCPVNVVGSSSGAIVVIRALERHPEAFEHVLIHEPPAMRLLPDGEELRKNQQHVYQLYLEGGVIVAMQTFAKLVKISPKELQALIPSPSSAPDPYRVGNMTYWFDREMLVYPRADIDIKKMENQKKRVRLLIGSESNEEGMQYRANVELSHKLNLPLHKVPGGHWGYQTDPKEWANKLRDAMRSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQF6</accession>
    <name>A0A6A7BQF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_171352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="137"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="50"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="452" mass="49282" checksum="59EA7E60DE977783" modified="2020-06-17" version="1">MPYSIATETLTGVEKLKRTCLGKLVLSVAKFLAWTPHRARYDEAKPPKFTLALNILYGFAGAFSSANLYYTNPILNVLAKDFHVPIAMVANIPALIQVGYALGLIFICPLGDQVRRRPLVLGLTFAAATLTMGPALIPHLPSFQANQFFIGIVVITSQIMSALVGDLAAPERRASSLAIVTSSMQCGVIFARLISGIMTQYVSWRNVYWLSTAMQYLIFALLWLLMPDYPVTNKNSGPYYRLLIKMVQMFSKHPVLVQASVISFFMSAVFTSFWTSVTFLLSKPPFNFNPIHIAPFALVSVPTMLLNPVYSRRLTDRFTPTVVVFLALGYALFGVSMGMAIAPISIAGAILQAMFADFGRQTSQVANRAAIYAAEPTAKSSINTAYMFVTFMGQVTGTFTGAQLMAWKGWRVADLSALVMVFLAAAAALARGPRERAGSAGRGACSGGKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQI6</accession>
    <name>A0A6A7BQI6_9PEZI</name>
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            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
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    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="275"/>
        </location>
    </feature>
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            <begin position="72"/>
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        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="333" mass="36462" checksum="E950C204ECDAD97B" modified="2020-06-17" version="1">MSKINFDRILNFRDVGATINSLPAQSDSTTTRPVLKQGILFRSARPDAATPHDISLLRDTLGIKTIIDLRTPTEHAEAEKSNAPTPGVVPDARPDAVPEVDTTPLAGENNTSSKSHDHDDDDDRHHHHHHHHKPNQPPTPLTAITHRINLNGPAYTRRLLSHLPFPQKAKLAFLYVTGSPKPAISILGSQVMTPRGLGGLAIDTLLSSTKEIRHLFSLFSEERNWPVLVHCSQGKDRTGLVVLLLLRLVGVGVGDVGRDYASSEDGLVSEREEKVVELRDMGLPEGFADCEPGWEGRVCGFLDEKEGGVEAYLVRRCGVSEGELNRVKGRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR04</accession>
    <name>A0A6A7BR04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Daum C."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19065" checksum="01D631ED030B5A27" modified="2020-06-17" version="1">MATTVRGSLRNIISAPTKYNVCTAKSLLQGRDQTSEDDHNTCCDHGKIAVETPSLPECLLFYGVETTLISQSSFETSTSTATWHRDQRFQGPDSHSTVFSDRSSGSNAQQPTKASSSRASFTISKGRCGQPQHHAPRSNISIALLCHRFLSPEQRRTEGHIPDSSSTCCMSATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRN6</accession>
    <name>A0A6A7BRN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_266495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRN6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="27681" checksum="E51CBB622DB0B665" modified="2020-06-17" version="1">MYTISCIGLGENHFFISLYDLTCLLGFLQHGNPHVFSISGIWSYLKSAEPMPGYDPRFSNWYLSEMALMMQMNKCLPNDYVPMGYDFMSWGDLQVFLEKGFNVFELLRGCVRRVDPQDLSFRGSWVPTGATLQGQFNGGLVPQGQQGDGGANDSVGNQQRQLPRPSLGGVLIPPWPGPSYGHDEDGYGVNGQQRIPGVRSLFSCNFDDDMTAGGHGAENVGGQRLQTPTKPKNGDDDITDSRSEQLRTPNS</sequence>
</entry>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRP3"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="321" mass="35959" checksum="3FAB88C6C4A3C2D3" modified="2020-06-17" version="1">MSKMSTTTPDQNAAAPKYKLHATKSMANSDKAVPKQRCIGQRANQAKAAPKRKRDGQDGVETTEDKAASVAKKVKKTTAGAPQSVKAKTVAQAGSVKENAFGKPDEDADDDCGNVYADSPSSSFNRYVDDNTDDPQPHISDYSDPVQRCPAEYREVGLPRIVQNLRKAMHPLLRPIHALMSQTWWNDIKIEWDYTHEVTPDVHQVSRWDIISHFVTLAELDIACQYEYSSNYDMFWGRLNCKGNIFSIVKPMVDSLIRLGQRARKATPSHEIVLSVADRKGSRFCGIMEILRAKDICTDEQFLMTMTEQDVEENGYPVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRP6</accession>
    <name>A0A6A7BRP6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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            <end position="162"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="17594" checksum="A2301158129CDBA8" modified="2020-06-17" version="1">MSTRSLSTDSPMASSCVIEPTTTWNGCGCSLPPKIIRACPKHNRQTYTEGVKLSSCAPPKPVVRDGDCEIHIAAAKEMVKIKREIKMKKRMSYKMMGDGLGVIEEEELGEEYQAIIDRVLGKGYPGEGNKGEGGNKSKRNGGDKSKGDKGKKENLEFIGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRU0</accession>
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            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6604875at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="8388" checksum="5BB18E9BAB7E8179" modified="2020-06-17" version="1" fragment="single">LRQRASEYDCLPCRLMGSLAFTGLGIYTYASGRKQLNLRAEEIRRSGSRIGVMPRRLATLGLSASLVGIGVYRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRU2</accession>
    <name>A0A6A7BRU2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006020">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27952" checksum="3B109C4928D78DE7" modified="2020-06-17" version="1">MPAPSKRVKGVQVRRHFLIGNEAFPLPHEGFPDPAPEGHTKGWRVYVRPLPNGPDITTWLKKVQFKLHHTFADASRTVEAPGPFEVTETGYGEFAIEIRLFFATESGEKALYREHYLCLQAATGTGPAISERMETVEFNEPAQDFLKKLTSEEQFDWLKTKKGRGKGKKAEMVFEGQCEPSAQLPDRAPPGPTGIEWSTRFERQILEGLKSSAKRLDEAIEEEQQFAKEREKELASLAEKLEAARARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY7</accession>
    <name>A0A6A7BRY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="120" mass="13248" checksum="2236D7D87635444F" modified="2020-06-17" version="1" fragment="single">RPVPFQSSTRGRLASAPTGQPVQPTVTQPGRKRVASSLSLRPAPVTTGEFHARMDELNSDNANYLVKFCREDPNIKLAVLARELLEVKAQNKALTVRFDKQDEIARLAQQEAALGRVVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY9</accession>
    <name>A0A6A7BRY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_147565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY9"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="6427" checksum="D02B6BDF0B0ECACC" modified="2020-06-17" version="1">MGAVLSCVQSIFAAIGSAIMAVVNAVASVCMAIINAIVSVFYAIISCLTCGKVGRRGGGTMTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS47</accession>
    <name>A0A6A7BS47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_222087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS47"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="619" mass="67355" checksum="DF77B656209E131F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="109" mass="12242" checksum="E6761770755426B6" modified="2020-06-17" version="1">MLRNNYLPTLWRVSWLNIAQQRRGNPMNLIFHRVSCASSLWITIGILVSVLPILRNCVVSEILACCTLTFLPEVLKKIAMLKLFLALLGGPSHGRALSPLVLRSTHFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSD0</accession>
    <name>A0A6A7BSD0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_199222</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5778525at2759"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00010">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="60" mass="6870" checksum="F256590353A77CF6" modified="2020-06-17" version="1" fragment="single">STRRRSGRGRQNLTDGEKRHNHIMSEQKRRNVIKQAYSDLERLVPVLSEGRPGLSKADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSJ0</accession>
    <name>A0A6A7BSJ0_9PEZI</name>
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            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
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        <name evidence="7" type="ORF">K470DRAFT_137476</name>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="647" mass="70760" checksum="2DC5CB4580D2A823" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSP6</accession>
    <name>A0A6A7BSP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_259987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSP6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025420362" evidence="3">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="290" mass="31753" checksum="924916715D4FBDD6" modified="2020-06-17" version="1">MASKLLKAPLKLALVQLSAGADKSANLSRACSKIREAKAQGADLVVLPECFNSPYGTKYFPKYAETLEPSPPTNDQSPSFHALSAIARETKVWLVGGSIPERSPDAKLYNTSLIFKPDGSLADKHRKIHLFDIDIPGKIAFHESEVLSPGNKITIIDVDGYGKVAVAICYDVRFPELAMIAARKGAFLLVYPGAFNLTTGALHWELQARARAVDNQVYVAMCSPARDMGADYNAWGHSLIVNPKAEVMAQLGEEEGVVYAELKGEVIDETRKGIPIYEQRRFDVYPDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSV6</accession>
    <name>A0A6A7BSV6_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_272988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSV6"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="595" mass="67984" checksum="954D59AD3FFB6659" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSW0</accession>
    <name>A0A6A7BSW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_144208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSW0"/>
    <dbReference type="OrthoDB" id="5425482at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="11356" checksum="B9A627723D8AB1EA" modified="2020-06-17" version="1">MTLQLARTFNQGGYFARGLLSWEKSWVSSRTIEEGKCGAHPKTRSHFDDEEVQLSGHGFVGEKYDAVICFSGSNYMIKASNGLSVIGRIDDEVGSPLVNSPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSZ8</accession>
    <name>A0A6A7BSZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSZ8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11536" checksum="D1536C4478A35D2E" modified="2020-06-17" version="1">MQPEPSATVHWDITIMPRGFNGNRYAVHFIDMCAHFNMVYCCCSKAYTQRVIPRWAAWCENQHGTCLKEILTDGETWIDKAIKDDIARPRNQFFSNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT88</accession>
    <name>A0A6A7BT88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT88"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="481"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
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        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="869" mass="95409" checksum="59A29C2A701B5E3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTA6</accession>
    <name>A0A6A7BTA6_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Nop14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_251480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="751" mass="86292" checksum="6EEF7CD3F5DEE050" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE9</accession>
    <name>A0A6A7BTE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE9"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
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            <position position="39"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858413.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="18944" checksum="6CB9FAB52CE31244" modified="2020-06-17" version="1">MSSATNFYDFSPKDKKGASYPLADLKGKVVLVVNTASKCGFTPQYQDLEQLYKEIKPNHPDFEIIAFPCNQFSSQEPGSNDEIQSFCQVNYGVTFPVLGKTDVNGSEAEPVWEWMKKSRPGIMGMQRVKWNFEKFLISHDGQVVGRWASTTKPGSLKQPIEAELNKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTN9</accession>
    <name>A0A6A7BTN9_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">K470DRAFT_260410</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="520" mass="57062" checksum="6D657B123AEFD7CA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTP6</accession>
    <name>A0A6A7BTP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_278952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
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    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
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        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
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    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
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    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="227"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="512" mass="56674" checksum="822147164BD28E1E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU5</accession>
    <name>A0A6A7BTU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">K470DRAFT_260353</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTU5"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="27336" checksum="20CAE9530E6FD2FF" modified="2020-06-17" version="1">MTDARPRILCLHGGGVTGEIFSKQARTLIKNLPDFRLVFADGPFFCDAGPGILPVYADYGPYRRWLRWLQEHPAVDDESTIEELDYSISTAKNQDEGTGPWVGLLGFSQGAKLAASLLYDQQIHVEKEGRADTDYRFAVLLAGRSPLVSLSKYSESDACVRAGAVSEGFDYQGVSPHIVKLPTIHVHGLKDAGLHLHRRLMNQYHDPASTTLIEWEGDHRVPIKKADVEPIVEAIYRIARQQGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTY8</accession>
    <name>A0A6A7BTY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_221830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTY8"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="129"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="455" mass="50091" checksum="E0DBF363FD8B9E3A" modified="2020-06-17" version="1">MLPSAGTSNKVLLLGAGFVTRPTIVELDKADIHVTVACRTLESAQKLCDGLQHASAISLDVNDAEALEGNIEKNGLVISLIPYTFHAQVIKAAIKAKKHVVTTSYVSDAMKELDQEAKDAGITVLNEIGLDPGIDHLYAVKTITEVHNEGGRIVSFLSYCGGLPAPECSDNPLGYKFSWSPRGVLLAARNTAQFYVDGKQETTPGEKLMSTARPYLIYPGFAFEAYPNRDSTPYRARYSIPEAETLIRGTLRYQGNPAFIQTLRDLNLLSEERQDYLESHTVWKEAFARIIGSGTATEKDLTWAISSKVKFTNTEEKERILAGLRWIGLFSDEPITPRGTPLDCLCAALENKMKYEKGERDLVMLQHKFGIEWSDGKRETRTSTLCAYGDPEGSDGYSAMARLVGVPCAVAVRMVLNGDIKQKGVIAPVTPDIAEPIRLRLKEEYGIELKEKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU41</accession>
    <name>A0A6A7BU41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_259985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16564">
        <property type="entry name" value="RING-HC_RNF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="479"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="828"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="904"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="912"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="142398" checksum="C12780BDD72D32A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUB6</accession>
    <name>A0A6A7BUB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_116175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUB6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11766" checksum="431E253F11A3FE5E" modified="2020-06-17" version="1">MGGVREGSGDWGQDVLLVWVETYSRGFDWHCVCGHHQVPDRGHELVPVLEKCIWHMRTNYKKAVFSISHVWYRRSNASYAAIRQGDAEQVQAQDANATKPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK0</accession>
    <name>A0A6A7BUK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable lysine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_278314</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUK0"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="272"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="627" mass="71360" checksum="FEB252A84DD31939" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVE0</accession>
    <name>A0A6A7BVE0_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_250251</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
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    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
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        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="240"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858937.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121501" checksum="783D53135064FE51" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVI7</accession>
    <name>A0A6A7BVI7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_271863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="18241" checksum="679D6F36DE8AA115" modified="2020-06-17" version="1">MAPLKAGDKFPQDVKFEYAPITDPDPTACGIPQTYDASKEFSGKKVVLVSVPGAFTPGCQAHHLPPYIKEASKFFNKGVDMIVVIAINDAWVMNAWGKVNGIKPDSKILLMSDTKTQFSKNYGWAAGMGDRNGRWAMVIEKDGTISYAENESNPGQVTVSGADAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVJ1</accession>
    <name>A0A6A7BVJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_108064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVJ1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="35125" checksum="942C7BAA09D87888" modified="2020-06-17" version="1">MSITVAGKPVGPIGFGMISVSRKSSPDEGIATLKAALNAGANFWNAGEFYGTAEYNSLHLLNKYFAKYPEDADKVVVSVKGCFDMASAKALNDEKGVRGSIENCLKILDGKCKIDVFEAARGDPDVPIETTVGAIAEYVKAGKVGGIGLSECSASTIRKASAVHPITAVEVELSPFETKILTNGVADTCREHKIPIIAYSPLGHGFLSGELKKFEDMAPDDYRRNFPRFKSDVFDNNIQVAHQVEQMAKTKGCSMPQVAIAWVLAQTKLVGAPVIPIPGTTKVSRLEENMNPAKLSDQDVAELSDAVAKIEVKGDRAPEAFKKYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVP5</accession>
    <name>A0A6A7BVP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_300615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVP5"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="236" mass="25414" checksum="C444743D6621275E" modified="2020-06-17" version="1">MSQGSESSQLEEPLLGRPGDATQHDAPLYYNLILGTGIIAQISALLIVAYTWGAIFTHDVILFSAHPLVNTTSVLLLLNGVLLLQPTHTAEQKLSGTNFHAVFMAMSTLLALGGLGVIEYNKFSHGGTHFDSPHAVLGFITYLFLVIQVLFGVLQFYAPWVLGGVERGKAVYKYHRLGGYVTLALMVVTVCAASGTAYGFKVLGLRAWVYLLLGVGVLVGTGARVKVRKFGWLAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWC9</accession>
    <name>A0A6A7BWC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_219897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWC9"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="THO1-MOS11 C-terminal" evidence="5">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27235" checksum="AD9A42D47B44807A" modified="2020-06-17" version="1">MTDYAKKKNDDLIALCKARGLPHSGKKADFVKRLEAYDVAHEGDANTAEDEIDWDETAEAANAASTEPAAEAIEAGGVGEVKNPVQVPNQIVAEDAATTNDLIVAAAGDPAPNGEAKPAQEEKKEAEDEDDKANYTQGIAERTIDEEIEKRKARAKKFGLPEDSDEIKILERAKKFGLVEGSKAMGLLNTNLSERRDRKRKSSIGDNDNTFRKKKGNRRGGGGGGSRHRSGANWMSDADRAAADRRKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWU1</accession>
    <name>A0A6A7BWU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_282572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWU1"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025468142" evidence="8">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="142"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="483" mass="53593" checksum="B0DD592A7C5671CD" modified="2020-06-17" version="1">MKPTLLLALPLVFASQQEVLFPRPRSVAVIGSGAAGSSLAYHLSILSNHSMRITVFEQNSYIGGRSTTVFPYGNTTHYEPIELGASIFVKANRLLWDAVERYNLQLSSLHKAPREETSLHDEPEPPALGIYDGEEMVYETSHSQSKLSRLLDLIYRYGLAPLKTRRLVASVLEKFCTMYTGLPWTSLGAVAEGAGLIPVVNSTGELFLSESGVEERFAREIIQAATRVNYAQNLFQIHGLDTMVSLAAEGAVAVRGGNWLIFERWLVDAEVNLRLDTRVRRVDRSADGGVEVTFDRPDGVEAKEAFDAVVVTGPLSQSGIILSDPEEQVDYVTLHVTLITATERVSRTWLNGEPVPDVVLTTLPPDSAKNPGFFSLSLLDILPGPKSGKREYLYKLFSPQPLDEEGLSRMFPSANAVTWLHRKEWKSYPYAVPRAKFPAEQLGHGIYSTGGMDPFISTMESNALMGKNMAHLLMRDFKLRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX44</accession>
    <name>A0A6A7BX44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_207829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX44"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="146"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="267" mass="30476" checksum="3319109CD872FA02" modified="2020-06-17" version="1" fragment="single">IDIDGFDDEKYLAEYGDELLMHLATLEGEMITEDYYPDKQPHLSSSLRGEAYNWLLKLNAQLRVPAETLLVTMNILDRFLAIRTVDERAYWLAFFTALRLACKYTTIKMPDLKWCEQICFKKFTRSEFLTSEAAMLKVLKFRLSCPTAHNFLSRFSKVDGKPDDEVHTAAKAIAQISCLDVGFIGYRPSAIATASVFLARKALSRADWDPMEIGEVTGYVWGEVKGIYDFMLEFLRAPIRHHCFFAPARAGEPVNPIVGIRKWALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX97</accession>
    <name>A0A6A7BX97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_218364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the glutaredoxin family.</text>
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    </dbReference>
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        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2859355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">K470DRAFT_258483</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="672" mass="72454" checksum="C1BE652CE3EA3AFB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXY1</accession>
    <name>A0A6A7BXY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_258190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="BP28_C_dom"/>
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        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1445" mass="160068" checksum="6C6BD2E235636D29" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYA6</accession>
    <name>A0A6A7BYA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein YmL27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_217719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYA6"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11910" checksum="D9C73883CA62C8B5" modified="2020-06-17" version="1">MHPTQPLQKAIRRLPLTTKQGPHDYYKGNRTGSMGQHTKYGGYKIDWRKVRTYVCPDLTDFKLTPFVTPKLKAKKDSFAHTETKQPTDGKEYLKIWKENGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE0</accession>
    <name>A0A6A7BYE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_264998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE0"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="194" mass="21224" checksum="32BCBD9F2231D2D7" modified="2020-06-17" version="1">MSSRLLGMKFMQRAAASSEKDAAEPAAKRQRLSAPAADAPVKNVHWGNGSETKWRLNVRDLPVRNCEPPLRVVPAGFTVLDGEVEDAEDEDGPGRSKMEGRKSYGKFNKSVERQQNADATSLESEESFDEDEGEIDPSSDKNKAPFTVDLDKLTSISANGKPSLANVVCHKCGGRGHLQRNCPDKDSKKRKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM5</accession>
    <name>A0A6A7BYM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM5"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="319" mass="35039" checksum="C553792BD9280EA7" modified="2020-06-17" version="1">MNFTTVLAAIGCLYIGSKILSFLRLLLSVYVLPGRRIADNAPKGSWALVTGASDGIGKEYALQLAKLGYNILLVSRTQSKLDAIVSDLKKGSSIDAKAFAMDFAANQDEDYQKLKAIVDSLNIGILVNNVGQSHRIPVPFAETESREMRDIITINCQATLRVTQLVLPGMMKRRQGLILTMASFGGVLPTPLLATYSGSKAFLQYWSSALASELAEYNIRVELVQSYLITSAMSKIRRASWMVPTPRTFVQFVLKKIGRSGGAQGIAATSTSYPAHALMHWAISNLTPGPMNDVVIDFNRRMHEDIRARALRKEGKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYQ4</accession>
    <name>A0A6A7BYQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_218808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYQ4"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="93"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="884"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="958"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1196" mass="132343" checksum="502F00C745343A01" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS7</accession>
    <name>A0A6A7BYS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_294981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS7"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_lg_ch"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="26503" checksum="9982D19BC0066E3C" modified="2020-06-17" version="1">MADRFPSLDEFDAGQTEPAESTSDFLARERALLGDEAQQFASSDADLLGGEDEPTAPPSKAIDNSNIEVKEDAEDDMMGDFESSFPSLDNPPAGASTSAQTHSMTLPYHSDSRGISGPTTPEEEPKVITDWRNAREESIAKRDKVSEAKKEQTVKAAHEAIDEFYENYNNRKDKQIAQTRKEAEEFLNKREDTASGGTSWERIAKLIDLSGKGSGGGAPGTGKAKMREMLIALKKDTDAPGASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYU7</accession>
    <name>A0A6A7BYU7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_286869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="518" mass="55115" checksum="CA0242C639448AED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ20</accession>
    <name>A0A6A7BZ20_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_264694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ20"/>
    <dbReference type="OrthoDB" id="3930519at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="270" mass="28271" checksum="AD1F8DB4479C376B" modified="2020-06-17" version="1">MSQQTSPHGSQSRFSEEKHCKEASKSATTALHAQKKANQLKQAAAGAADPEERQKLLNDYFQKQVEAEKWGKAAKSLQSGALQGLLAGGGFGTGIGVGLGTITGVLVGGLIATVTGGLGAAVGSGVGAIGGPFLKIGHVAGNALGKISRTIPGWKATDEQKKALEKMLDLIEEQEVPDQAELERIQGQVKSVTNQVGSATKAAQNGPPGCGNINHSDQQTGHDSNGKPRAKPRKLEIRSADQSSATKSPRKPRKLEVRTQQAQWNYEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG1</accession>
    <name>A0A6A7BZG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_270628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZG1"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="40290" checksum="B8E3C78384658666" modified="2020-06-17" version="1">MLDENLPTFYLSGETVLFAINGEEPRAVYSLVGNVLRDAYFSDIIYGELGTHQNGGGHAGTEGDDRGRGDGSRVGAGVGVSSGGGGGSGGSGSKATLSNNAVPERERSLPHPLAITLHNPPLIVPLTHTHTLLREHYTFSLPSQTFRHPSPSALDLTLPSPGELDTTPRVSFTWRERGWGWGCYLSPSTPGSGMPRGKEPPILVAFAKGKEVTFYESNWKRVEVEDWKGLEVVLIISAFAVINAGAAGRDAAATTTGAGLRRRVSFLGRATGGGGGMLRKNAIPEEHVDVKRQEERDRVLAVKLQRELDSKERRTREEELRRETERLRKEFGAKKSFWGLRDRAKSEGQVQKPTGMVKRSKSFFGLKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG8</accession>
    <name>A0A6A7BZG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_71126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <source>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="142" mass="16236" checksum="67C705ABD1BBE9F6" modified="2020-06-17" version="1">MENQSLYLQNLPEKWAKWDLGRELYMLFSTYGPVLDVTCLKTKKMRGQAHILFRDVNCAARAMRACQGFVIGGRKMKISYSTNMSNTLRILEGDCSKPETKKAVEQKADARAPSVQAGTKRSREESDEEEQDEEMEMSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C140</accession>
    <name>A0A6A7C140_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_257136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C140"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="71"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="397" mass="43654" checksum="8D0EEFD5D7DEF0EA" modified="2020-06-17" version="1">MAESDPEYDPNDSDHAPKPSARSKHAKWEAPATSRWTLPPVPTPTSDVPPPPKHQRQLKDTTPLQRGIIRNVLLILDLSSSMSQKDLRPTRQLFTIKTCITLVREFFSQNPISQLGILATRDGICTEISPLSGNPSEHITALAGLRSLEPRGNPSLQNTLEMSRALLYHTPPHSSKEVIILLGGLMTSDPGDINTTIASCVKDHVRIRIIGLSAEMFICGEICRRTNGGAGGYYNIATDEVEFERLVAEVAIPSVVVMREKRGRGAELLRMGFPSRGVGRDNSLASLCACHGKLGRGGYMCSMCGARVCALPTTCPVCGLMLILSTHLARSYHHLFPLRNWVEVPWEKGECFGCLRPFEDGEGQGRYECTACHQHFCINCDVFCHEVVHNCPGCLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C159</accession>
    <name>A0A6A7C159_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_206949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="88" mass="9884" checksum="5109F1C5182FFC74" modified="2020-06-17" version="1" fragment="single">HPALSSLPKVIEGGQAAEPLYNTSKMRRLQDEAEKLQKEIGEKEGRKRKGLLEWEKLARDVDVAALKSQLAEKMCREFSGESEAARAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1A9</accession>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">K470DRAFT_245617</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="MU005973">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_asu"/>
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        <property type="entry name" value="RNA_pol_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF05000">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="575"/>
        </location>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004279"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861290.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1470" mass="162981" checksum="D514E7DA55BCF72F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1W9</accession>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <cofactor evidence="1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="4">
        <location>
            <begin position="106"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="484" mass="52352" checksum="C8FEB908155DB9E9" modified="2020-06-17" version="1">MTRVSVSEIIKHSSPDDLWIVVNGKVYDLTNFAPNHPGGADVLYAFAGRDGSKTYNEFHSATLIERELSDSEKKGELDEGTLTEEWLEAQKTELEKAATGDDDAKPALSSIISLHDFETFFEKSSNQKGFAYISSGANDNLTREANLTSWSQIRFRPQILNDVSAVDMRSSMLGVPVSMPVMISPMGMGKTGGPQGEKALGHCAAASGIVHCVSTVASYDITEVVAAAPQANYFFQLYVDKNRAKSEALLRQVEALPQVKGVFVTVDLPVVSKREADERISSAPQNLVRPGHQGPKIDEKGAGVARTTGGFIDSTFSWKDLVWLKKATKLPIVIKGIQSPLDAVKALEAGCQGIVISNHGGRALDTAPSTLEVLLEVRRDAPHIFDKIEVFVDGGVRRGSDILKAVILGARGVGIGRPFQYSLAWDDKGPLACAEILQDELGTAMKLCGITNLDGVRGRTEWLNTVELEAKLPPPLPMLVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C266</accession>
    <name>A0A6A7C266_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_214553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C266"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="8">
        <location>
            <begin position="168"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="9">
        <location>
            <begin position="354"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="674" mass="74868" checksum="759AB8DBCE6A4A71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2E0</accession>
    <name>A0A6A7C2E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_245187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2E0"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="742" mass="82412" checksum="81D600BDAFC480C4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2G8</accession>
    <name>A0A6A7C2G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2G8"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14486" checksum="B0EB5F22F393FD49" modified="2020-06-17" version="1">MEYSAASHGAWKICDAYLKTAHIFPPDIKITREHVTLKALSHVTAQLGVEIPRVLYHGEWDDKRFIIVYAMKGQTINRVWNTMDDDRKANCVRQVVNFIKVLSTQEADYVGGVMAANFSNPGFRTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3F9</accession>
    <name>A0A6A7C3F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_214298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3F9"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="13643" checksum="D8D7C75D3202AF3D" modified="2020-06-17" version="1">MAAIGSLLFCTDCGSLLPPNPDRKESIECDLCSTMNKADTLSKVVVTTSKPSAFPSTLRTRLRSDVQEVTESDLQTQATIKKTCEQCGHDTLRFYTQQLRSADEGSTVFYTCPECGHKWNENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3J3</accession>
    <name>A0A6A7C3J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="229" mass="24433" checksum="AA601FE4D7D0E68F" modified="2020-06-17" version="1">MLTCSSVRSRFAKPSLWRGFSTLPNNPHIYAHWSDSRREYNLSLLPDASSGMPIGSCPNIPPTPDSFRENNDFLQLVQRVIGEHAVNDPDVQAQAAMYTSQAGASLGSGGLFFPGQRRHKRRGETGPKVAGGGGGSGGGGAGGASAQGGIGGAGRGGWIHVSDQRNPPDLGRVAWPEDIFGSLELDGEGRFVDGTGRYQKNDTYRVVTKEGILGLSPFLRKKLIERLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3P9</accession>
    <name>A0A6A7C3P9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_256181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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            <end position="167"/>
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        <location>
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            <end position="111"/>
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            <end position="99"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="160"/>
        </location>
    </feature>
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            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="160" mass="18120" checksum="5D64B837366A87B7" modified="2020-06-17" version="1">MCTILSVKRKICPQFENHECTDIIEKTYYLRRACTSCVEEVGDPIVNWHLVHQSPGKEAPTAKHEEDTATGHKEGTKTGHKDTTTKHKKETVTKYEKDTVIKYKKGTMIKHEKSMTTKHKKQTTTKHRKEKDSDSSSISDTNLDTSSTTSSDMSSNDSDD</sequence>
</entry>
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        <submittedName>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="WD repeat-containing protein slp1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="283"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="448946at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="159" mass="17488" checksum="D4A2940788B5998C" modified="2020-06-17" version="1">MYRVAFVRAARSASQKLPRAQRSAFSVATRARFIQPSTNKLAAVVSSPRWYSSTAGLDKDEVTGRIMALLKNFEKNDGQDTDSRKISANAHFTNDLGLDSLDTVEVVMAVEEEFSIEIPDKEADAIHSVNQAVDYIMAQPDGKSKSINALMLNLTRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4B0</accession>
    <name>A0A6A7C4B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4B0"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="389"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="563" mass="60075" checksum="E9AA8C1A1E65B595" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4G2</accession>
    <name>A0A6A7C4G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4G2"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
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                <person name="Bloem J."/>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MU005968">
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    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:tripeptidyl-peptidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S53_propep"/>
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    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
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    <dbReference type="InterPro" id="IPR050819">
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        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025630477" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="221"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862115.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="611" mass="66473" checksum="1A9AF97F017C2AA3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5C4</accession>
    <name>A0A6A7C5C4_9PEZI</name>
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            <fullName evidence="5">High mobility group box</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <end position="69"/>
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        </location>
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        </location>
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        <location>
            <position position="72"/>
        </location>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2862640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="8183" checksum="320D52CE9AA3B517" modified="2020-06-17" version="1" fragment="single">HVKRPANAFILFRKAHSQAISRVVGGDNGQISAIAGKMWKEASAEVKDEFYQRAKEEKERHAKLNPGYKYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">50S ribosomal protein L35e</fullName>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F3"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14952" checksum="D457E18712DCA212" modified="2020-06-17" version="1">MARLTAVKAAQLWGKNKEELGKQLEELKKDLVQLRTQKIAGGAQSKLNRIHDVRKSIARVLTVINANQRHQLRIFYQKKKHLPLDLRPKQTRAQRRALTKEESRRVTAKERKRKQHFPQRLYAVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C670</accession>
    <name>A0A6A7C670_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_256157</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C670"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="520" mass="57724" checksum="EC6419E627D0F521" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C680</accession>
    <name>A0A6A7C680_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_227796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C680"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="311"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="49703" checksum="3704FE7DA5467958" modified="2020-06-17" version="1">MPFAVADLSSSEISNVFDTNMPAEKGNYILKVLHWRRMSGALIDVGLDFPPEQHVSRDDALKGLTYLRNLDPTFDEEAAAQVWVEEESLRLTDRIAKRAQELGLYQKEGPAPAVAGEAEQTSIYGESALTRLVAANRAKAEFEESLREAKRLADETSALHAARGPLHLLGGVQPSISLSRGLLGGLTIREAPQSGSLIPSTKPKWIEKYETSSQTIKEGDAIPETSSLKRLAPAFLLTLAVVYAATSLAEGYTPPPSSARVWPDTDPAKATLLTLSSALGGAFILSRLPPVWGMVNRYFTIVPAKPYAVSLLGACVRHDTLSHVATNVAALWLVGLPLHEEVGRGAFVAVFAASACVGGFVSLAALVLRRQWASYVFGSSGAILGLAGASVGIHPEGRMRAFGWECPVPNWGVLLAFGGLEGLAAAGLGGRLLASRVGIDHVGHLGGLIAGFGLVRYLTLKRENGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C698</accession>
    <name>A0A6A7C698_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_212195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C698"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="140" mass="15443" checksum="CB98450DAAC62A2B" modified="2020-06-17" version="1">MELVAAVINLVGVILLSHAVYSAYEFSLLPNTPSPPVIKAIPALLDPKINLPLDIVLETIVSVLLLCLGVVLSSPKLEPIQWRVWAGMLERSKAARKMQDVGVGGNPYVSLDIRPGYRDIRAQRQEYQAWAEGKKEKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6G1</accession>
    <name>A0A6A7C6G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_255477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2326"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2417"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2417"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2449"/>
            <end position="2461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="2468" mass="275223" checksum="CDCAC0936C77E75F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6H1</accession>
    <name>A0A6A7C6H1_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_268362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="32185" checksum="78ED6D855F08D07C" modified="2020-06-17" version="1">MRPIFPLVRFGISCQQRNASILSSLSNVKSSYSHPKRVGRGPSSGKGKTSGRGHKGQKQHGKVPAGFTGGQTPDHIVHGERGFVNHFSSKFSKVNLDKIQYWIDKGRLDPSKVITVRELVKSRCIHGIQRDGVKLLAGGKEELRSPVNIVVGRASAEAIAAVEKAGGAVTTRYYTPWAIKMIMKGLMDPVNSLQSRLISAKETEEGAQAAADEIMEERRRYKYRLPDPASRKDLEYYRDAARRGYLSHLVSEGEGPSLYFHPKTAEGKGKGIDMRKKRKESEREANRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6P5</accession>
    <name>A0A6A7C6P5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative sphingomyelinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_211653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6P5"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2863053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="442" mass="48927" checksum="BA809469C2F1B404" modified="2020-06-17" version="1">MPEKPSSSSPRVLNVLTLNCWGLKYISKHRSARLALIGETLASLTPSPSIVALQECWTQADYRSIRQSVSQILPYAKFYYSGIFGSGLAIFSAYPIVESRMHAYSLNGRPQAFFRGDWYVGKGVASARINLGGGVQAEVFNTHLHAPYGWQTEDSYATHRVAQAWEIARLMRDARDRGSLVIGMGDFNSLPNSLVHKVVVGRGSVFDAWIVAKPDSVRETADVISSKEALEKYGTTCDSRLNSWRWSKNERARKPFTPDPGAPDAGAKRLDYIFFSPPVREVEKGDNWGVKDVKVGMTGMHPGLECSLSDHFSVEASFAIDSIGTVPLTQCHQTPQTDIHDQILFLISSYRAREEQVRKIGMIHLLLSPIVSIGCLVGIWWTPSNWMAFVLALASTLALTTGILHGLIAGLFTGSELRLLQEFEEEVREAKRFEGTSKISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C750</accession>
    <name>A0A6A7C750_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C750"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="19835" checksum="21FF630F1BB673A3" modified="2020-06-17" version="1">MEDLMVISQEKEVTPGLALETWNAQMEAQGAPQAGQQQQQQQQQAQTAVGFAPNGVPMMARTPSMQSMAMSAQAGAFPSPHVAQMQLPNGINGSPHFGYAPAMAASYTFPPGAHAMSPRQGAMAAPLMMAQRSQQGTNSSAASGTTSPTVNNKRRRSAAKGMEDDGGEVHGMQRMKPSPRIAKKSKPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7J6</accession>
    <name>A0A6A7C7J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_255113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7J6"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="407" mass="45036" checksum="AC7A3A210965D374" modified="2020-06-17" version="1">MSSRLPLARLTCLRCARRIHSTARARQEALDRTFFWTNAATKRARRQQCQELPPDASATLSKAAAAAPAKSAKRKFSIYLALTKPRLAFLVVLTTTASYSIYPVPSLLSAAATDTPSLSALTLLYLSSGTFLAIASANSLNMLLEPAYDAKMSRTRNRPLVRGLVSKRNALLFAIATGAFGVTLLWEGVNPTTAILGGSNIILYAFAYTPLKRIHPVNTWVGALVGAIPPLMGWCAAGSQYSTVQSEGVWEEAQELLFSRQAVGGWLLAALLFSWQFPHFFALAHGVKHEYAMAGYKMLSSSNPRMAERVSLRYSLAMFPICVGLSQYDVTDRSFIFTSSLINGWMAREAYRFWKCNAERGTSRALFWASVWQLPIVLVLAMVQKRGLWERLRLSLGDELLYDEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C849</accession>
    <name>A0A6A7C849_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_140597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C849"/>
    <dbReference type="OrthoDB" id="3791653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="176" mass="19462" checksum="81BF059A2884DB91" modified="2020-06-17" version="1">MHNSVGNLNSKGIPSYAEVQGPLQDIIDKRSFKETTNTYHTVTTTRHSGAQPRKDRHHDGGCTWCNKYGYFYKNHVFKTCRRAKPNFQGSKVKKRAHRPDTANQAAVKEEATALVAVMEHGLTSIATNAPSPWIFDTGASRHMTCLDDFSDFRTAHGTIQIAGGQTIPSTGLSPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8N0</accession>
    <name>A0A6A7C8N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_292704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8N0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025417866" evidence="2">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="282" mass="23655" checksum="F3967AC04EBB5919" modified="2020-06-17" version="1">MTKLVFLTSLLTAAALARPYAGGLGSAIPGLGSGSGALGSLGGLSGLGSGSGSLGGLGSLGGSGSSGGASPAGSAAPMNCGGCSSAGCPSCGGGVSAATGMPQRAVTVNYAGGSGGSDGSGGSDGSGSSGGVSGSGSAGGSDGSGGMGGSSGTGGSDGSSSSGGMGGGSDGSGSSGGMDGSGTSGGASPAGSAAPMRCSGCGGAGCPGCGGSSSSSSSAGSGSSGGVSSSGGSGGLDSSSSPGGMDSSGTSGMGGSGSSGGASPVGSAAPMKYKGLAAAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8T6</accession>
    <name>A0A6A7C8T6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8T6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="53" mass="6137" checksum="821CA5DFAFAB3A49" modified="2020-06-17" version="1">MNEYDAWEKKKQPRTPGNHGVCRSVRSGPLRFGPHRIQGPDPDTHAFCTQLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C915</accession>
    <name>A0A6A7C915_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_279842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C915"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="487" mass="54447" checksum="75676CAF8C1BE10C" modified="2020-06-17" version="1">MLSNEKTAGDGATTINDATVNDFNVPQCPPHTTESKLMRRIDLHVIPFLCILYLLAFLDRVNIGNANVYGLAKDLKLKGHEYNVALVVFFVPYILFEIPSNVLLKHFKPRLWLSFNMFGFGVVTMCQGFVKNYAGLLVTRTLLGVFETGMFPGCFYLISMWYKRSEAQKRYTFFFGSTTLAGAFGGLIAAGIGHMDGTAGYKGWRWIFILEGLLTAVIAILFFFILPNFPEDTKWLTPEEKTYVAARLQVDQGKAALERKMTGRDVARLFKDWKIYPGAFMYMGTLVAAYGYAYFSPTLIKTYGYSPIHTQLFSVPPWAAAFVVAMTVAALSDKVKMRMPFALFCTTLALIGFCILVSVHDNIDLQYGALFLVTCGSYSSMPLLICWFTMNLGGHHRRSVGTAWMISVGNIGGIIAVFAFLQADAPKYIKGYSICLAFDVLALVTIVTYAIMCLSANRKRRRGGPSHLTEEEKTDLGDMNPDYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9G4</accession>
    <name>A0A6A7C9G4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_279859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9G4"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
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            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="431" mass="46274" checksum="C3E913586CA18B90" modified="2020-06-17" version="1">MGGTQPGPEGALLGFRDFLKKNDVESSIESLVRLLKLGRIKGSRPCALATCHLLVRVVAAERIRNVRLLTGRIRAVGRRLVAAQPKELTVGNAVRRVLGIVREVAEDESGMHFESPASGIATTPKPAGTPPSYEISADPASRPSLRSLGPSYAGHAAAVHSRLHFLQGLPSTTLVDRSLSASSSPKQDQGDPSLGKVDIKAEVIDGIKDLIEEIRIVDTQISDSALEHVHSNETILIHTLTPTIHKFFTAAAKKRKFTVYHTADCSGADDSDEVYERRKSLTSLGITFVVTSKTAAFALMSRINKVILSPYYVLSNGALIAEPGTGTIALAAKTYRVPVVVLAGVYKISPEYPLPAKIDTLLQYDNSGETLGLSDAGEAGDIQVLSPTYEYVNNECINLYVTNIGSHAPTSLGRVLSDHYRPEDVDLSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9G5</accession>
    <name>A0A6A7C9G5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_254616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9G5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="184"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="376"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="638"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2863719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="764" mass="83656" checksum="1CBBA8126DED5457" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9H7</accession>
    <name>A0A6A7C9H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_81416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8780" checksum="AE829C403F3E0A56" modified="2020-06-17" version="1">MVNVLVQRPADRRSNVAYGQSFRIYALSPRCSPHAENQPLYTAFVSGSTDVINGWDKAMVSLEHVETNRARKKWDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9S9</accession>
    <name>A0A6A7C9S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_199779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
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            <end position="178"/>
        </location>
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        </location>
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            <end position="202"/>
        </location>
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            <position position="1"/>
        </location>
    </feature>
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        <location>
            <position position="801"/>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="KAF2863755.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="801" mass="87715" checksum="BE2AE050AB623950" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9U9</accession>
    <name>A0A6A7C9U9_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldose 1-epimerase, putative"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864346.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="398" mass="43771" checksum="1D48AB4ABFDD1910" modified="2020-06-17" version="1">MFLLSVGSLLLTLANALGSSGNGPDEDGKYTLTSEGIRAQFIPYGASLTNLFVSDVHGIERDIVLGFDNASYYSQTPFHPHLNGIPGRYANRIRNGTFTIDSETYHTDLNERGLDTLHGGRDGWDYRNWTVAVYGGDSITFSLDDADGREGFPGRVISNVTYTLTPYTWKISMTAISLTKKSPIMLTSHTYWNLDGFQNPDTPLALNYTLHVPNAGLRTEVDGTLIPTGNLLANVKGGVHDWWSAPKRIGTAFDEGDALRGQCGTNCTDYDTCYILNRRDGKKTASIATLASPFSGISIDIFTDQAAFQLYTCNNMNGSFALKKTQGFFNDTVAHPRVTKKYGCVVIEVQDWIDGINHPEWGRKQIYAPGETFRFDAEYKFSTVDVCKGNGTTTGTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA15</accession>
    <name>A0A6A7CA15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5586401at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9171" checksum="7865067F3D8B4A68" modified="2020-06-17" version="1">MSGSKQPEKVVSQDVDDEEPDDWDKRIYSTGCAKENTKLNECFFDKKDWRACKDEMEEFRQCWKRQGNDQRTESKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA28</accession>
    <name>A0A6A7CA28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_239312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA28"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="37833" checksum="4DD0858C234CC1FD" modified="2020-06-17" version="1">MASPQQIRTTLTDLLQINHPVMLAGMNVAAGPKLAAAVSDAGGIGVIGGVGYTPDMLREQIAELKGFLKNKNAPFGVDLLLPQVGGSARKTNYDYTKGKLNELVDIIIESGAKLFVSAVGVPPKHVVDRLHAGGVFYMNMIGHVKHVKKCLDLGADMICAQGGEGGGHTGDIPTSILIPSVAALCRGKTSPMTGKPVQVVAAGGIFNGQSLAAALSLGASGVWVGTRFILAEEAGAPKAHQEAVRTAGFDDNVRTIIFTGRPLRVRNNPYIANWEENRQNDIKTLTGKGIIPVEHDLENVGDEVDDETMDNMRPFLMGKAAAVVNEVKPAKAIVDEIVSQAAQVIRDNNSCLVSKSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG0</accession>
    <name>A0A6A7CAG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mog1p/PsbP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAG0"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="188" mass="21116" checksum="5F838C7665180B8A" modified="2020-06-17" version="1">MEFQSTELYGGAIKVDLPKNFIDASHLRDIPDHEELFIDAEGFTSIIIDITEHVAMPTESEAMETHLQDVVEEDRPATEVARLRQAPFAKLPNTMASMLIASTPPSERHHGRPNAPDVVGMVMIRATLAEQNSDVVITINVPHVPGYYNREEVDIQNGRYGTLMEQAIECRDRILATFEVVDWNLFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG3</accession>
    <name>A0A6A7CAG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_208413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAG3"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="146" mass="16887" checksum="029E5CE20571D50C" modified="2020-06-17" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRICDEIAIIQSKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDFAHNSESGQLDVDQETKDMLKSMGFDSIPVNVVAVPSQTITERPRRTGDRLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAN6</accession>
    <name>A0A6A7CAN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254395</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAN6"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="979"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120349" checksum="116471EB8D5A6BD2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAW6</accession>
    <name>A0A6A7CAW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_208813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAW6"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="24461" checksum="DE65CFFEF6D147FA" modified="2020-06-17" version="1">MRTISAKNAAALDEELMSSGQFSIDQLMELAGLSVAQTMYTLSPPSKSQKILVACGPGNNGGDGLVAARHLFHFGYKPAVYYPKQSSKDIYTHLRAQLEQLNVPFVDEFSGQGYDFLIDAIFGFSFSGEVRDPFKQAVAGLEKAGAKVLAVDAPSSWNIDHGPPEDGLGKDYMPAALISLTAPKALSKFFKGRHFVGGRFVSKAMADKYDFDVPDYKGCDQFVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB16</accession>
    <name>A0A6A7CB16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_291976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB16"/>
    <dbReference type="OrthoDB" id="3633909at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="41735" checksum="B1169F844C98350C" modified="2020-06-17" version="1">MSKSYVYLSGPRSLEYFVPGSSSEDSDWDFYVPHSPEHKGELILALQGLGVHWLGRKDEILAVALGEDGGTMKIEYESLVYPRRNGSLNYITQLTGLQFTWAASELARDCKVLLSVEKIGDELWVSKSDRCDYYSGLDLFYLLRGSLTYRKKTMPVQLMIDNRINKATYRVPLKLHSSCVQSFIGAHCACYMYDELASRCESYAWVDHENNADTKLERSGLLLGWVPDPVQSMYKKQWYLGWFKYRTGGYKCVEAEEADKREPRNCGDAASTWVEYLDPVPSAPQSVFSYYIRANQQLAWDDENLVRTIQTNLDGQIDKPLGIPELDEWLKRTDRREAERLLDHYVPIRRNLSPWSYRQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNZ7</accession>
    <name>A0A6A7BNZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_261148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006072">
        <property type="protein sequence ID" value="KAF2857074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNZ7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="85" mass="9599" checksum="F004C1506DD17AFE" modified="2020-06-17" version="1">MFRLSVRSTLFKIVFDTAPQRVLYAAHSENASILFGITACIVVGRSQSTIVTAEEKHRTWKIRQSQLVARSITKLASMRGMMISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPL4</accession>
    <name>A0A6A7BPL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPL4"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="549" mass="60529" checksum="69756455417568AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPN4</accession>
    <name>A0A6A7BPN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_206461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006052">
        <property type="protein sequence ID" value="KAF2857301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPN4"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="10">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="220" mass="24024" checksum="868782BE0C65D073" modified="2020-06-17" version="1" fragment="single">QHAILTSALSHIPTHGFSQTTLSLAAQEQGLPEISIPALLPRGAADLVLFRLQKERLALSRNIQPWFSSPSAPTSSPPSQPHHGRTDAPTLRNIILTRLAANRPIVTHLKQSLALISLVENLTPAVNELELLADEIVYLAGGKDLGPAWYASRMGIMGIYFSAEILQSNPNTEWRDVEGFVYRRVDEFKKVGSVLGSIGEWAYLQARGVVQLGRNTGMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPW2</accession>
    <name>A0A6A7BPW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006048">
        <property type="protein sequence ID" value="KAF2857361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPW2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="61" mass="6744" checksum="F3D3192A5A5E7E12" modified="2020-06-17" version="1" fragment="single">MAIRNITHPAINNVPPPKKTSALNASKKTQPPSNENSHPFTPSAFPSWIELEFEPAFLTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQM0</accession>
    <name>A0A6A7BQM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="132" mass="14195" checksum="4ADA8FC357AEFF87" modified="2020-06-17" version="1">MSWQAYVDTSLVGTGNVDKAAIFSADGTGVWGVTKGFNVDPKEMSEIVAAYKDPGKDGVKQVQSTGLHVAGERYIVLRADDRSIYGKKGREGVVIVKTMQAILVAHYPESVQPGAATKTVEQLGDYLIDAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQR3</accession>
    <name>A0A6A7BQR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQR3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="165" mass="18336" checksum="AB48E9AD4AF69AB2" modified="2020-06-17" version="1">MQSSVVLSRADGMFPRHFAQAPVTALEEGLESDVCICCKGRRSVAPWNMVTYPSLLDVAVGVPNTVEKPIRVVNFGKCKYTLTAVMYSNDLELGNSAAQDRSKTRHFFGHAYFKGAFLFNDGLDSYTRHTLAEYQAAKHAIARVWYQKTSDGFAIDAIFENGVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQR7</accession>
    <name>A0A6A7BQR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006066">
        <property type="protein sequence ID" value="KAF2857115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQR7"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17577" checksum="7B7B6472896D248F" modified="2020-06-17" version="1">MRRGNFVHKTPYVILDNPSEVRKDLNEWNIAAVKHEIAIYKRIWPYPGLVGGFEIAEDCFVIDYLPRGSLECSKEDKNNQRPNDKQMHAWYLELAKTYSYIHKCKVFVADIAARNVLVANDDSLKVVDFGTSDLFPENWEGPLLGDCVSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQV8</accession>
    <name>A0A6A7BQV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_301499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006062">
        <property type="protein sequence ID" value="KAF2857155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQV8"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="27529" checksum="63061351138ED80A" modified="2020-06-17" version="1">MLVRKRSHDDMEGTLVMQMFQSFRSELDEHHDRRERVIKASRDVTAASKKVIFSLQRSAILSQHFQAKRSAGAAVWPHYNTIRTHLSSVAADLQGINAARYERQITWGLQEWMEAVAFETYLEEAKLLTFDDAVARLRSFAEGSAMPLTYKDYLLGIYDTTGELMRFAITTMATGGQVPAVSGQPDRNVVNDLRMLRAALESLNSGRGPFANEVDKKAQVMRTSVEKAEKALYGLVVRGAEMPAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQZ2</accession>
    <name>A0A6A7BQZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006066">
        <property type="protein sequence ID" value="KAF2857109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQZ2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="434" mass="47849" checksum="61B102B3D4D03FE6" modified="2020-06-17" version="1">MLVGASGLLRLVCRVNDIAELVRLVAPLFIVGPRQVGRSSRCGYPSLVPVHSHNNTPTLSIVPLSGTTQLQDQQSNAWPGSRGGARGRGKGRGGKRPLVEEAQSVPNLKRVRITAERYDQSLIESYVDKDYEDNDHSVDEDLVDDEIRDDLGHIGNANHVDFVEDVEDDDNLTEMRASIAPSVTHPTPLPNGGPSILRAQHQRRVTAPLGLSAPRAPPAGTPVPSMSDDPLGIAGSLSQTARVRPSRPTMITADAALPNVALGVAIKYIGKLVTMNKELHIRLQALEAWVNEMHKTKAAEGGICAAMRQLLFWKHARGALWGDNSAVAAELRSRGVMEKAPTQSVLTEISQIKSDLRQNLRKRLRDKWKVSQCFASRADFLKQWDLNYHLLRLIFKRDLQRHGWEKGNGGRGLPGRQGPSRVNRLINNSWTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRN1</accession>
    <name>A0A6A7BRN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRN1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    <sequence length="421" mass="46409" checksum="D7C10F1518256A46" modified="2020-06-17" version="1">MPEGLRVIILGGGIAGLTTALALTKFAPAGQKPQIDIYEIRPEPATIGGAVNLTPNALRLLDHLGTLPIIRERDYGKTIDYLEVFDIYSGKLAESSFQGPEGKGIGNPPYKALRITRGDALKGVLAAVESHPNIRLTCGKRTVKIEEDANKVTIHFEDGGSASADLLMGCDGIHSVTRLKHVEPERKAVYSGVSNAFGFAPIDKGFKVHFECTAINFARRGMLLTSFFNSKQDSVYVGALMQIEDVGSRDGWKSVGADAEKTRARLMERFGDAKIPCVKPLIEKAQDFFLWPVFTLSKHGKWSTGRTMLLGDAAHAMPPQGESTGIVFEDTVLFSRCVARWMEKGCPGSDLKEPFEAYEKLRRKRIEAAFDESKNVVSTVSDAGWFGHTLKTYIVPWYLWFSKGSREQHFIEDVTTVDIGY</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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    <sequence length="804" mass="84282" checksum="06B797A514CD1121" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="217" mass="24261" checksum="283878C0DB6754C9" modified="2020-06-17" version="1">MDILLGLGISLPIVTSNGISVVTGVSQGVRQQQRANAEEKERMRKFHIDVSTEDGSLEGIVTLRDGRLWIESQTSHVHPFTGFFLPYPSPSPPHPLGMVSTISADPPLLNWIYIDRETNQVMYGNRTASIQHIVNFGYNDEGNVLGGDEAWEGFVIVEDEMGKGKWSLFFDISDDRLRHLPNRGKRRTKEVFLKRRMLEDIPETIGVKTVGNIGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BT66_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="17303" checksum="C035FBE89564299E" modified="2020-06-17" version="1">MVAVGRKKAQKTDAKNERAKALIKRNKILERHGVRVQFDVNDIMSKLSAAAQEYFRIEQEIVLEKSRAHIAELRVGNGNIAPEPPVTRLSQLVMSPKTLSWKDPVSTSPVRCRRLTALFSVLCVLRVYFSLIPSGSNTTIFMYPLLPPLIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT77</accession>
    <name>A0A6A7BT77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_221370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="188"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="592" mass="65541" checksum="7A075D74899BBE3B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTA5</accession>
    <name>A0A6A7BTA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_259646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2858566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="27805" checksum="394D49700F195F1C" modified="2020-06-17" version="1">MAQTLTKDPAKEDYITLSDYEKLTPDTFFAHKPILHFHSQAALRVPTLDLSLRPDFASLFPNYTNATEEEETIVDIWVFSTHLDLWSRLTRRGVRFRYQMITMHALENQTVIYEIALSDPNDPGDDEEEREFLHLRLSPIGPGDVKKLYQASVACQELNPSPRDDDGDEDMTAPGATGWITSDNIDNYRNMFDSNGDTSMGNSDVPQQKGPLGTGAGKRRRRETVDNTDSWFHKWQRTNDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTC3</accession>
    <name>A0A6A7BTC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_283556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTC3"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="222"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="337" mass="37885" checksum="3B786971BA4D4501" modified="2020-06-17" version="1">MPLFMTSLDDVDEDNEQIQALRALAYEGTRAEIAENFRKQGNECVSEKNYIDARKFYAQATEALNSPQTEPVENEEEEERKEKAIAEACHANSALCNLQMKNYASCQRDCAAALRLNPDNIKAWYRAASACLAIDKLPEALDACENGLLRDSNNASLKALLTRIENRRDHLDALTKARREREAGLALDQATLKQALHTRGILARQTDDPPDMEDAVVGLDRPRDYKSTLHFPVLFLYPREAQSDLVKAVTEEESLGPHLELMLPPPWDTAGAYHPDNVDCYMETRPGGLIKAGKKVKLLQLLKRGPVDIVDGLVKVYVVPRADVAAWIEDFKKRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE4</accession>
    <name>A0A6A7BTE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_283138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE4"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="674" mass="75107" checksum="BDB162F235A53EAB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTH6</accession>
    <name>A0A6A7BTH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_220952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTH6"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
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    <name>A0A6A7BUJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_283157</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUJ0"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="43"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="511"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2858637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="737" mass="78645" checksum="7214ABEB8473A057" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUX0</accession>
    <name>A0A6A7BUX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase I, D subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_235704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUX0"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="188"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="458" mass="52295" checksum="DCA0437BE1EC226F" modified="2020-06-17" version="1">MASLARLARRSPVWRQTPRFSARWLSSTRSRFADINPYATRLVPEDNHDTYLEGEHVNRTTDDATDPEHRKVRHYTVNFGPQHPATHGVLRLILELNGETILRADPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPERAKWIRTLFGEMTRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVSQDLPLGLLDDIYQWATQFGDRIDETEEMLTDNRIWLARTKDVGTVTAAEAVNLSFSGPMLRGSGIPWDIRKSQPYDAYDQVEFDVPVGINGDCYDRYLVRMEEFRQSLRIIHQCLNKMPTGPVKVEDYKIATPPRAAMKENMETLIHHFLLFSKGYTVPPGETYTAIEAPKGEMGVFVVSDGSERPYRCKIRAPGFAHLSGFDQMSRGHLLADAVAIIGTMDIVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUX1</accession>
    <name>A0A6A7BUX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_135924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUX1"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="12594" checksum="3B63B30B3CBC3A80" modified="2020-06-17" version="1">MANDEPSRFEVELEFVQSLSNPLYIQWLSTMKILDAPEFVEYVKYLCYFRRPEYIRYLARYPGPTIRILELLQQEQFRKDIINPTVVEKMMNEGMEFYAPPDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW03</accession>
    <name>A0A6A7BW03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_282814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW03"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="29819" checksum="2A237A50DFFED54E" modified="2020-06-17" version="1">MADHSQERPLHELLSRDMVDIYVGPENTHWILHEKLLCYRSRFFRKIFYYDNKTAKYKNHTYGVPEEEDGPFRLFVGWLYSEQVPPARHEEDLAWLFDLYLMGEKWEIKSLQLDVLEAVRQYYHDNDTWPELRRVQYIYANTAPESPMRELLMQCVARMLVLREDGLPAHWEKALRHNGPLAVDIILCVQKWHALEADRVPDVREESVMSFVDELEHRAEVIGCPFGHEEKLVHGATTRGWGSGRRVGEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW74</accession>
    <name>A0A6A7BW74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_99008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW74"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="506" mass="57270" checksum="42A0036E0FE20443" modified="2020-06-17" version="1">MLPWRPHLCHVLPVSWLRPHPLCRLPRRDLADHLRLYVNMFRSGWLITTDIIKQVISAMIRCGWEDAGANGQQDPSEVYTFIANQLHVPLITLMRETFHNGQEDMLADHKIELERTIELGIPEPEEGDGGEMALIDLLCNFFSAKVEVGRVLPKKLADLDSQPSTPRAGDSPRAKAPHTVTSETAAPREEIIPAWQMSKFLPFFTYHEESLDPELARHFADRRPVLAICLKRYSASASGTTRRNDFVQIPLEMHPSDLVGGDDLGLEPSASKDFRLVLQSAICHRGKSTDYGHYITLFREHPAQWPGTEAGIPEEKPWKRFDDLNIQERIKSVDIHQALRQETPYLLFYQVQSTNAETALVSEKPGQEIPSTSAEKREIVEGTMPVEVDHEVIWTQTRRGIAGIFFGGYKSEAEGGKPSRLSWLRFKRRTESGATVAVGEDPEPAHVSSRPSQQTEGTNRCSIASEDTLKSQENADSNGQPRRKRVGRRWLRLLPHNSHFRMFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW96</accession>
    <name>A0A6A7BW96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="21"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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    </dbReference>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="236" mass="28165" checksum="6C4129DBBE61C71E" modified="2020-06-17" version="1">MPGDPSFLAALAVEIPTLAKVVANFPHGNRFFDRRSEAYQGWERVKSAIRRTAQSYKERRCSPYVYWFDDLRRSSYGFWEDVPYSFQILIIRERDGTDIWDEIDRERDRVLRVDGWLPVYYSDDSNGDDYDDDDNDWIFDLTYEFIGDVSEDDDELIVDEPEEDEFEEDYTEEDEFKEDELEDDGTEETEFEEDEPEELESEQDDSDKTDEDMDMQDDTKESDYDFNSSDLEDKIH</sequence>
</entry>
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        <alternativeName>
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        <alternativeName>
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        </alternativeName>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="69" mass="8122" checksum="EF5EDD186CD89718" modified="2020-06-17" version="1">MHLMYTLDASGNRVYTLKKNVGEEMTKSAHPARFSPDDQFSRQRVTLKRRYGLLITQQDKDKKVMGRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXE2_9PEZI</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
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    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="288"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
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        </location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="693"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="376"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="762" mass="83513" checksum="5E55EB77AB417D78" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXS9</accession>
    <name>A0A6A7BXS9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_282651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
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    <dbReference type="OrthoDB" id="197206at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR002307">
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    <dbReference type="InterPro" id="IPR023617">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
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    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2859519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="46275" checksum="523D9CDB2AB7B4B3" modified="2020-06-17" version="1">MASSMANTPAEKLALITKNLQEVLNPEIIQAVLEENQRPVKIYWGTATTGKPHCGYLVPTLKIAEFLAAGCEVTVLIADVHGFLDNLKAPIELVEQRSKYYTYVITALLKAIGVDISRLKFKTGSDHQTKNTGYFMDFLRLSTCVSSHDASRAGSEVVKQVKAPPVSAQIYPIMQSLDEEYLGVDAQFGGLDQRKIFTLASEILPRIGYKRRAHLMNPLIPGLQEGGKMSSSDPDSKIDLLDSEQVVTKKLKKAFCPPKQVEGNGVLAFVQYALLPASALKSPNGIPHFIVKRRDGEDLVYSDFRKMKDDYENDILQPQTLKPAVTEALQAILAPIREAFAEDKEWQEVERLAYPPPPEKVKKVKKAKEHGQRPVDKASKDRVAAKPDGSLEGEESRVKEANLGQVPREAVEKLTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU7</accession>
    <name>A0A6A7BXU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_288071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="26757" checksum="6AE95B0B782A0E9A" modified="2020-06-17" version="1" fragment="single">MDLYAGEASDYRFSAIAAASTNNVPRRPAKMASLPDPYETEPDIEREKLMYALYGGGSEEEEGHKTRSEGSKKTDSSAVTKQRKKLNKSSMPPKTTFELDPCRPSFLLVRPVDNYGYLPDGSYFEINPPTDEKATKTPFWQHAAEKHAAGAYEALSEATIQSHIIENSGILDTKDAIKQRDAFDHREGPAMINIFETQCVLRRWPTSASWQLTKGGKTGLMQQTHSRFINAQRVHSLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXW1</accession>
    <name>A0A6A7BXW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXW1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9256" checksum="7729B0027FF63A65" modified="2020-06-17" version="1">MEQSTVHLISQLSSGFDALQAAYRILFSHTKGLERKLATAREQVRTASLYDEYTIALDLQYSIEDKAYTISESKTDAYSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXZ0</accession>
    <name>A0A6A7BXZ0_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 213 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_249077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="19619" checksum="1DA0597163DBD1CE" modified="2020-06-17" version="1">MGEDYQPIDTLRSTLKAGLYTGLGGLFLTTIKASLTRAPIGAFAALRKHGATTAVSGGMGAAYMFAKSATANLRENDDATSASVGGLFAGAVLGLRFGTLPAVVGYGSALAATLGTFTYLGGRLRGFPAFGDEMANKQAMRLNRRRPVEETVRELGEGRGIYGPGYEERRAQRLKDAYGVSVPTTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY38</accession>
    <name>A0A6A7BY38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY38"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="52" mass="5696" checksum="5732B8308EEB3B23" modified="2020-06-17" version="1">MMSRPPTVEGRRYIAEPNMRNPGPNDVEFSVVYPGGDRPVANPSNEPLGSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYP6</accession>
    <name>A0A6A7BYP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYP6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8533" checksum="7B68A1C947BB6E2B" modified="2020-06-17" version="1">MKPSLKPPRRRSLCPKHVYSVPFAWSGFTLVFSPLVWDATAPQNSALIRWSVIAIFSTILGLAIKDVFGGQRGQGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS4</accession>
    <name>A0A6A7BYS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_258384</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS4"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="198"/>
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            <end position="418"/>
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            <end position="809"/>
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        <source>
            <dbReference type="EMBL" id="KAF2859859.1"/>
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    </evidence>
    <sequence length="815" mass="93706" checksum="5574E2491F827BFE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ23</accession>
    <name>A0A6A7BZ23_9PEZI</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="13" type="ORF">K470DRAFT_258468</name>
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            <taxon>Capnodiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 480.64</strain>
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        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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            <end position="156"/>
        </location>
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        </ligand>
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        <location>
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            <end position="186"/>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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            <end position="209"/>
        </location>
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        </ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="357" mass="40914" checksum="6390EB10C0E04CD2" modified="2020-06-17" version="1">MMGMCMSSGGAAEGEGRKRSQAIDRSLEEDSRRLRRECKILLLGSGESGKSTVVKQMKIIHQNGYNLEELSQYRQTIYKNLIDSAKALTGALGQFQIELSTPENQTWAKWIDEYSPEGDTQHALDPKLADAVTAVWGDANIPQLMKHENEFYLMDSAPYFFTNVQRLISPDYVPTESDVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESTQNRMNESLVLFDSVVNSRWFMRTSIILFLNKVDLFRVKLQRSPMVNYFRDYTGGDDVNRAAKYLLWRFSQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ88</accession>
    <name>A0A6A7BZ88_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_299684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
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        <property type="protein sequence ID" value="KAF2860550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ88"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="582" mass="63735" checksum="D66AB4D2CBF5D4B2" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7BZF5</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860493.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="401" mass="43409" checksum="EFB42CA84B1CBC22" modified="2020-06-17" version="1">MPCDRLGHYHQWPVAAGGPTLTVYRCERFCGYCEGEEALKVWEQAARLRRHVLQRHCRPDGRGTHPFVDFNPHWTDDPPTNKPPKGIRKDGQARKKAHRTKESYRQKSRRASARQIVAAHPEVFTAEQRGSTQSKGANVIHPGGDGCQPQGNGSTPEIHPDGDSHDNVQRGIDGNSSAGGMASPGASTSVLGPRFQGSNNPQPSSIMPSPVRPETAQVAIFDQVFGQGSIAYGMPTQGHMPAGHGINNMQNHLATGQSLFTNIHQVTGSSPAVYYSLHYDPQIRQSIFQATAAAGHDQGNIQAHHYLHSTAVPNVTQVQGPQGNLFTQPPVATSASFHPASGNNFPIQNAPITLQGNTNPVNGLERTWQTTNNVSQQGNAPASTCLRWGLDTSILDKELIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG3</accession>
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        <submittedName>
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        <name evidence="4" type="ORF">K470DRAFT_217066</name>
    </gene>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="260"/>
            <end position="412"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="632" mass="70880" checksum="CD288222D381BCD8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZY7</accession>
    <name>A0A6A7BZY7_9PEZI</name>
    <protein>
        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZY7"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="204" mass="22981" checksum="770CBA0D7EEA2A70" modified="2020-06-17" version="1">MAEIISQDPRQLHDDGDDLTPQDARPIKRPRAGADDDDEDEKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEPETNGVDEHVDSPADEHHNPSSAAPQMAPQMRSQPPPYMTPDQQQALQYQAYMQHQHASHQQGTYPIPPTQGLHQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0A8</accession>
    <name>A0A6A7C0A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_264129</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0A8"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="18">
        <location>
            <begin position="114"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="574" mass="64744" checksum="2172A145F9A692ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0H3</accession>
    <name>A0A6A7C0H3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="12">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_257353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
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    <comment type="function">
        <text evidence="4">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
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        <text evidence="5">Belongs to the BCD1 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_HIT"/>
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    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="212"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33586" checksum="F1E8568948125906" modified="2020-06-17" version="1">MSHQTSSTTHNPHAMLCTTCYESASKYRCPACNTRTCSLTCFGIHKTQKSCSGTSSPARYIPKQTLRNVDWLARDYQFLRGVEDAIEKGVKIDERREKSMGEEKEDEEGNMAPQTSVRGSDKVKELIKYLRKNEISVERAPAGMSRHRVNQTRGRMRRGVLKVHWTVEWVYNSPEGKKKREIRHGVHSELRVVDAWTGRDGFQGGGFPGKDAPVEDDKGGKIGHSLREGDASQSEDRDPTQGDAPSLGKKDNLAESQPRFFLQQSGKGEIPLCPKETFTEALKCRAVKEFPTIRVEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0J1_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Auxin efflux carrier</fullName>
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    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_247914</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="508" mass="55746" checksum="AA2F61D8ED854352" modified="2020-06-17" version="1">MAQHPNFLHLAGLVCEAVLEVVFVALPGFVVASNGMFDASSQKFVAELNMMVFTPCLIFTKLASQLTAEKLGDLIIIPLIFIAQTFISWVCALAMVRVFGFGGAEKKRQRNFILAMGVFGNSNSLPISLVMSLSKTISGLHWDKIPGDDDDEVAARGILYLLIFQQLGQLLRWTWGFSVLLKPAAAYETAAIDEVEAAIEEYRDEPDDLEDGLVKSYPDSAFSSGAHSPITPRVSSDADEQPLTSPQHPTLDRARSTGHITTFPNYSSNVPHPSRVTPKTAVRRLFHPVANTMTTFWKNQFRRLPPSLQAPLRKFQYHNAAFWKGVWRQLNPPLWAMIAALFVASIPALQRLFFTPGTLVNNSFTRAVTQTGGVAVPLILVVLGANLARSTLPKEQLAISAEEKAEEQRLLWASLLARMVLPTILMAPLLALVAKFVPISILDDPIFIIVCFLLTGAPSALQLAQICQVNGVFMGVMSRLLTASYVVAILPSTLVLVLLALEVLQWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C155</accession>
    <name>A0A6A7C155_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
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    <sequence length="262" mass="29277" checksum="B4688912A84AA2FC" modified="2020-06-17" version="1" fragment="single">ISAIAKHLDLNSLHELSRTCRQIREALLQNRRLLVRQALRCENDTANSRGMVCARDLVGECRKCGTVVCRNCVVKTTKSDLNGRYRRLCRTCLKAPLERLSRSETSQIQTNIAQTPCMCVERGIWLCRACGQALNTADRQYWRGWLWRTKYSQCGGFGTGLGERQVGVECGRGSDCLAATTMEHEIEVDDEAVSAEAEAAHRRHGNSYTTQEVEGIGGLIKMKMKKQVLVGAAVEEYNDERDGGINRSWCSWCDGVVAETRG</sequence>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Mondo S."/>
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        <source>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the complex I LYR family.</text>
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    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
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        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="98" mass="11452" checksum="BD56FF641661A527" modified="2020-06-17" version="1" fragment="single">TAGNVRSLYRSLLRQGRQFANYNFREYALRRTRDAFREPRNGADEIRETMAKGEKDLQMMRRQTIISQFYQLDRLVVEGGKTGKQTHGGDIVRQKDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C214</accession>
    <name>A0A6A7C214_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_281547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="417" mass="44456" checksum="455118D7471AB675" modified="2020-06-17" version="1">MLYLILSLLPLVHSYSTLLYRVGSTYADVLAPSQDPWYSAPSGWESSAPGTVLRVRAAPGNLTSIITNSSAAYNILYSTTDSNYNATWAVTTLLIPHTPAQPQSGVQSSQPNSLLSYQIPYDSADVDASPSHALYGNDLAEVELALEQGWYVSVPDYEGPFASFTAGVQSGHATLDSVRAVMRTGFGLSDQTRYAMWGYSGGALASEWAAELQKAYAPELSFAGAALGGLTPNISSVLLHINEKISAGLGPAGTVGLASQHPELQAFLEENLKKEGQYNATTFMSVKGMNLAEAIGAFANQDLGEYFVNGLQTLESPLAEAIQTSDGFMGLHGVPQMPLFVYKAIGDEISPTSDTDALVQKYCDVGVSILYQRNEVGEHTSESLNGRVRALMWLSAALDGKLQQTGCQVEVVNVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C261</accession>
    <name>A0A6A7C261_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C261"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="35427" checksum="C5A5C6C697A9CCF2" modified="2020-06-17" version="1">MAAVARTSTSSIPENLAVATVLPNGGTLLDGSEEELWVHRDKLLRIESEEMLAEDGERGRSRSAERLPAPQQHQRAKRSTSSRIPVSVAKLPAERERSATLPLNSAPTSVSSTSPVTSRPTSSSKAKLPSKPGPASKRKQPHSRASSASTRARTPRPLSINRPEGDAPWLATMYKPDPRLPQDEQVIPTHAKRLEMERLKREGHEVPVQDDFPPSAWPPEHDSNKTSTPPPEPPNIAEQPSKNPVVAASRSNSVYFAGTPQGWIEPPGPATGTNAPGYRITPSIAQQGQQSAGSRPPVAAIRTMDPEQVDEKEPRRGFRSKCCCGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C264</accession>
    <name>A0A6A7C264_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C264"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="30628" checksum="FFDB6C01F384BA98" modified="2020-06-17" version="1">MKRVVGSTLVVWRRLYPTDGKYSRRCLRPLQRSSGVIVGRTDSDVVHGRQVTHNPTIYKCYASHIQQRGWGNISSRDHLRPVNVTQREDVDRYNAYLTWMQDYRVDELLAEAAAFQENEVAAVGPSYAIGRVNAQDDMEEFGLTEPASVGNDFQAIMEEDFEVLDEGSSMDGTNSADEDTDPVHDSDASFVATSDSNETSDEDEDEDEEGDKENESDSVSSEIDRNRPLFSSSSLFAPLDSLLIAEPLHQWSPFDIPFVQVAAERSARNDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C294</accession>
    <name>A0A6A7C294_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_263963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C294"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24704" checksum="6256C0C292EC6BEF" modified="2020-06-17" version="1">MIGICARTWRDLWSCVLAEILKGSTGGLGNRRSSQRDRIIFLLQANVQNGSPNHDPILSHGAPIGAAILYGAGAMDCVRRIQPSISHQNPPRLYPIPAFWRGISQTDGRDLHSQPSSLGGMQSAPRPSWDIVWVKVSGHSDSLDTVNVYLHAGLHAPDRFHQLQSATGTFPSRTFMAGDFNLRSRLWEPGASKTAGAQLSHIRRRIKTSLCAIHLKSLLTTDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C304</accession>
    <name>A0A6A7C304_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_214263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="22725" checksum="044D6A695528BB95" modified="2020-06-17" version="1">MAFYQNDFVPMFRFLDDYANHVASSSDRRVEPASHVKSLTSFKPKFDIQETKDAYKLHGEFPGIDQKDISIEFTDPQTINITGHYDRSYEEGERPQQQQQQQQIEHHKPTVEDEKADSKESEPSKEVTQQQQKVQKQQSGGKHTKFWLSERSSGHFSRTFSFPAHVDQNNVKASLKNGVLTVTVPKAEKVSKRIQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C316</accession>
    <name>A0A6A7C316_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_263757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C316"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="115" mass="12499" checksum="C4F7C88E308CFE25" modified="2020-06-17" version="1">MTAEHSAVENSLHCKISADPAVENSVTLSRRCPCGNCITRGVSAPTQFPILADRDEETVKIYPQNMSGNVSQCPLTTWEHGHQLPRASTPCHVPAEPKPKPTCRPMGVAPHRTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C327</accession>
    <name>A0A6A7C327_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_214807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C327"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="29535" checksum="F5DC96DC0849398D" modified="2020-06-17" version="1">MDLSILPLAQPFAGNGVTGVNGRRVSDMSDVSTASPAQLETLLKHYRELFAKLRFLYVDHVTKERFLLAISESPPAYVSVAENAKLESVLFDKDGLKADLKTRKEEVAAMMSELKEQGRSLAQRYEQLQHDMIQMEGIPHDIEALRQTIATLDTIENEPDPLLRLPLQPTEDLVVEREKHLTTLDEEIEAFQSSITSEYRRLEQLQEELDPLDKSRQQAIQELEGEQQQTKSSKYIGHQLGGRGRWLKGENAVLEEILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C419</accession>
    <name>A0A6A7C419_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_243369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C419"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF61">
        <property type="entry name" value="GRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="410" mass="43698" checksum="A79794BD12AFB112" modified="2020-06-17" version="1">MSAAVEAVTSQLSETTLNNPLPTAEGATIGSGGNAPINASQNEAVIASAAEGRRLYIGNLAYATSEGELKDFFNDYLVESTSIPLNPRTTRPVGYAFVDVATPAEAERAIQELNGKSILDRKVSVQLARKPDANTEGEAGEGKPARRQSARRGRNRGRGNRAQGGRRATNDEAEATGENAGGEATASNVPAHADALTQTTNEAVTAEAGAEGASTAKTKGKPNNTRPRKQRGPPEDGIPSKTKIMVANLPYELREEKLLEIFADYSPTSAKIALRPIPKYMVRKLQARNEPRKGRGFGFVTLASEELQKKCCDEMNGKEIDGREIAVKVAIDSPGKEDEDPNVPSKGKDEAAAQAEDKNEKSDAKKTDDESKDKSETKADEKAEKAEKTEKGDETTDGKQAETAKADAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C467</accession>
    <name>A0A6A7C467_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_256678</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C467"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="871"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2861839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119978" checksum="C564D0257EFB29B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C472</accession>
    <name>A0A6A7C472_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 480.64</strain>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Binder M."/>
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                <person name="Salamov A."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M2"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="29"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="367" mass="39649" checksum="27EF9A900E24A299" modified="2020-06-17" version="1">MSNEETPHTTSSKTHPSTTNNDNLGVFTTPTHDLYLSPTPTPALSAGEILVSVKSTGICGSDVHFWKSGRIGPMVVSSPHILGHESAGEVIAVHPSVVTHQPGDRVAIEPNIICGECTPCLTGRYNGCEKVEFRSTPPIPGLLRRYVAHHAKWCHKIGDLSFEQGALLEPLSVALAGLKRAQLALGDVVMICGAGPIGLVTLACARAAGAEPVLITDVDEGRLRFAREFASGVRTLLVKPGTVEEFAEEVKQLMGVEPDLVMECTGVEASIAGAIQAVRFGGKVFVIGVGKEEIKVPFMRLSTREVDLQFQYRYANTWPKAIRLMRGGIVDLRRLVTHRFKLEEAKEAFEVAADVKRGGIKVMIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M3</accession>
    <name>A0A6A7C5M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M3"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="517"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="689"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="328"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="783" mass="87022" checksum="9FC363D2D9CD3F32" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5N4</accession>
    <name>A0A6A7C5N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_268747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5N4"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="377" mass="42375" checksum="4A7C782F4A234532" modified="2020-06-17" version="1">MAAQQIQFAETIRAMKLATRRNAQQRQDVGDDRLPLSSSNRGRKLDEDGLNNTGHKIRINYAGYERPIMSRLPTRYDEDGDVVEEDEMEDEDIDAEPVEDNPFADVQLEKTLAPLTSAAELPHHPSYSRAYTDPGLTRLVKDVEAMLRRERNILWKAKRFLQSLRGDGQWMALQRYQTDGDEQLLIECFNVEVPRLQGAADGTVAQETVAQTVDGAAEAHGGAPRAAATSSASSDGSPPPLNPWFRVPAAARTDHDMGLPPQEAEDTRRAFILYIQKQDITVQHLEMLYAGLQRADRQRREVFRACKAEGHMIVDSRGGVHTEMSDGEDWYDPSDWGLEAGDLHDGKLEKGKEDVEEAGEDEGRRVPRRRRFNNARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5S4</accession>
    <name>A0A6A7C5S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_298404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5S4"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="555" mass="62427" checksum="DAAA1A8010420B12" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C611</accession>
    <name>A0A6A7C611_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_275227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C611"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862499.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1018" mass="118660" checksum="40FE82DAF9C525CB" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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</entry>
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    <name>A0A6A7C687_9PEZI</name>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="38357" checksum="81D9D5BC8B526EF5" modified="2020-06-17" version="1">MLVIASILGTNWSNRLAIDYICFAVAMDKFMGIAKGGWHPSNDPAIKRDTWKSDLKNIATGRRPDPYEASRNHESAPLSSLRDPNSFAPPPKRGSDLGRPAIPARPAFTQSESEPSASTPPEPYRMDTTGLRTDHLPKPPMRQSISAVASASSRTPVLPPRQGSFGPKPGLPPRTNSSSPALPPRREQPPPPPPYQQTVTESPQPTADRQPPFGGLSAAKNYVSGVSTSASAPQSENQSANQSAFSGLTSAKKYLSGGSDAATPPGQANKPATPSPSTLASAGKQLSELQQRFSRMGTGKETLPSSTSTSSSSSTLPPAVTQAAASHISGFKKPPPPPPPKRSSLRSETPAEPPPVPLSSKPKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6B1</accession>
    <name>A0A6A7C6B1_9PEZI</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6B1"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025502061" evidence="1">
        <location>
            <begin position="28"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="449" mass="49631" checksum="12492CE4EF807F23" modified="2020-06-17" version="1">MQGTFWNGTHWPSAIQWTGAFIDTLLAASDISLLASPDNANDDVLKYKRQIETYFNSEDVIQIFGAAYDDVQWVVLEWLEVIKFLRRYDPEADLSRYAHRAHIFYHVVQDKFNTSLCNGGLTWNPALATYKNAITNELFMASSISMYLYFPGDQNSDPYPATNYQNITNATLPVLSSLAAHDSSLLENAQKGYEWFKAQNFVNTQGLIIDGFHISDNQTTCNKPNEMVYTYNQGVILSALRGLWEATGDESYLADGHALVQTVIRATGWSGVQGQWAGLGRNGIMEDYCDAALNCSQDAQTFKGIYFHHLGQFCEPLPTTTALVPGLTKLASSSLAASHAGNCSSMTSWIQHNTQAALSTRNKTGIIGGWWGADDGNTFLSQSLQGAAQLPRNSDDYRNNPQILHEPPWICQNCRTIHRRDANDGGRGRTVESHASGLGVVKAASDFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6C1</accession>
    <name>A0A6A7C6C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_17789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6C1"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="387"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="555" mass="61175" checksum="6DF9443869CEAF1E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6E1</accession>
    <name>A0A6A7C6E1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NGG1p interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_256215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6E1"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20757" checksum="500EE64E30F13767" modified="2020-06-17" version="1">MQRGNVAGMPLYMEKIESPTPTGPLASQYERPIKRKRSETPAGKKPQVLPSLASVIDPKLIEQSHGRCTLEQGRPGITQGCAVSISPSPSQGSRCEAGPASDQQYMSMSMDKAESRKAQNRLNQQRFRMRQKQKIEQLEAELREERRLSQLLRSQLDIYWRLLKQEDMEKLVGPSIPCPVALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6R7</accession>
    <name>A0A6A7C6R7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
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    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="251" mass="28837" checksum="37E1F2D298875B30" modified="2020-06-17" version="1">MFNGDSPRHMLSQLNSRYVYGRYPLLHAIVAFVQIIMVGFLMRRFNASYAARPVFTTMVTNAVLGGIADTVAQTLTAFKRRQRQRQRQRNSDPEAFNPKDDFFSVEIQELDRKVPWPDSSRGKLAPPPFDFERLVRFMAYGFIMAPLQHRWFSFLEKTFPLSGGKATTNAMRRVAFDQLIFAPCGLAAFFAFMTVAEGGGKRAVVRKFQDVYIPALKANYILWPMVQMLNFRVMPIQFQIVSNFSLAVMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C762</accession>
    <name>A0A6A7C762_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_210901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
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        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1718"/>
            <end position="2041"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1382"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1545"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1390"/>
            <end position="1403"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1553"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1620"/>
            <end position="1639"/>
        </location>
    </feature>
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        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="2062" mass="230960" checksum="C436CDFB14DEDE21" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C768</accession>
    <name>A0A6A7C768_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">K470DRAFT_212471</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29148" checksum="B43546850A57E550" modified="2020-06-17" version="1">MPDEIPLSDLPGSAELTRNVTINLSQAQYERMFFQPNQPRHGDYAKRFANPTLLGPIGLTVPLTSTVLCLLGTAGAVPPYSTVGVLGDYYMIGVISMVIAGLAEFILGNTFPFALFVLFGAHWGAIAYQQDPITQNIAAFAKLGGPAGKIYNSSQTFHYAIMALFCAMIAIASIRVNVVFIVFFFALTGMFASIAGAHHGVPTESAEWALHRLKIAGGFGVLAMVMGWYLLLVTMCETVGLPCPLPVFDLSGKVFKGYQEKMLLREQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7E4</accession>
    <name>A0A6A7C7E4_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">K470DRAFT_205964</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7E4"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="51179" checksum="86B611D8308CF946" modified="2020-06-17" version="1" fragment="single">PPRSMPSHSHSRSSPAGMDAAQRYVPYGQKTPTQASNPKAYNISHLQTPTGAPSHSPLSLTAIRSRAVSDAHDGVSTLLAYSDAPANSAYLAPFPTYAYDWCKWPVNSSGSAGKMAVASYLEDSHNFIQIIDSHAAAQDDGLEYSKVAEATCAYPVTRILWEPPGSQKQSTDLVATSGDHLRLWSLPPGPPPQYGNNITSRAAALREPAPQKLQPLALLSNSKTPEHTAPLTSLDWNTLSPKLIITSSIDTTCTIWDIPTLTAKTQLIAHDREVFDVRFCAGSVDTFVSCGADGSVRMFDLRSLEHSTIIYEPAEKDKEASPSSPMKPQGPPSAPPLLRLAASPFDSHLLATFAADGNIVRILDVRQPGTALLELRGHSCSLNSIEWSPNRRGVLASGADDCLVLTWDLVNSYNQAALGPAPLSSGLVPESQAKGPCSSWRCDFEIGNISWAPQSTLTARSGEWLGVCAGRGVYGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C832</accession>
    <name>A0A6A7C832_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vps5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
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        <name evidence="12" type="ORF">K470DRAFT_254747</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 480.64</strain>
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        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
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        <text evidence="7">Homodimer.</text>
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            <topology evidence="7">Peripheral membrane protein</topology>
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            <topology evidence="7">Peripheral membrane protein</topology>
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        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
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        <text evidence="1 7">Belongs to the ATG11 family.</text>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
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    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="108"/>
            <end position="453"/>
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    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1072"/>
            <end position="1227"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        <location>
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        <location>
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    </feature>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367075"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863871.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1353" mass="150241" checksum="32A3F7D8F260AA71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U5</accession>
    <name>A0A6A7C8U5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_267496</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U5"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="60"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="180"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="382" mass="42457" checksum="731ACB20156D18EC" modified="2020-06-17" version="1">MVPHPSKLPTSPAQRASATPLTSKVESQWVFTEEELANSPSIQDGMTRAEELEARSKGIDFMVQAGIMLKIPQLTLDTAAIFFHRFLMRASVKRKRGSMPLLDQFQIAATALFLASKVEESSRRTRDMILTFCCVAQKNAELVLNEKDEEYRFWQQCILDNEIEMLIALCFEFSVESPHKSLCDLLKFYQLDKNKQVRDFAWAFISDSNKTPICLLADSLAIALAAVSFACHKCNVDLPEDWHELWGVSESKLAMVIALMDELYKTEQQKLRNMAALQQSEDDSDGGVMLVENTPQYGPTPLARSDMSNAGRGTTSSYSIAVATPGNTRDEDQVHFEERMRVQTGNQQAFLTASVTTGYPEGQAGAGASNISDGAEEGEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Y9</accession>
    <name>A0A6A7C8Y9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_254600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Y9"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="321" mass="36127" checksum="C567DEAA9B2B59B0" modified="2020-06-17" version="1">MSHQENHTSAITDAPLTTIELSYPKLASGKVREIFDIGSEKLLFVATDRISAYDAILKNGIPSKGIILTQLSAHWFKLLTVKFPKIKHHMLTTELPSSISQEEKSCLTGRCMQVRRLPVVPIESIVRGYLTGSAWVEYQAKGTVHGIQMPAGLKESEKLESPIWTPSTKAEAGANDENISPDMARDLVGVELGRRIEEASLKVYEFARDYAEERGILLADTKFEFAHDPDTGDLVLVDEVLTPDSSRFWAKEKYCVGQGQESFDKQFLRDWLVSSGQKGMSGVEMPNEIVKKTLEKYFEAYRLLTGRQDLRVWFNGEPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Z8</accession>
    <name>A0A6A7C8Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_209822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Z8"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48302" checksum="F0A19ABA1A214E65" modified="2020-06-17" version="1">MPDTEIADLAAGEGEEEEDVDEEEDARASQAVDDDSESGTAAKRGSKNVRKGRGTGRGGRKRGRVDTGSAVVLDKDGQAAEVIDDEVQVDDDAEGNTKVDELGRLQGGREYRVRTFTVGDKGPRLYMLSTEPARCCGFRDSYLFFAKHPKLYKVVLGEEQKKDLIERAILPNSYRGRNIAVVTARSVFKEFGARIIVGGRRIIDDYKVAEAREAGFVEGELADPEDIVPADKNKYNRNRYVAWHGASDVYRTSMNVNAHNKQTATVKRKSHVTRENWQLEHAKEASRFNSRLTTMRRANQNGIYDVNTNLMFYPQTMQPTHAKWERVTNSSNSTFPPLPEKIPQNFFVADMQCLGAPQAGAGYPGPDGHIRDVASGNVGGLCGIADEIIAELPPSCRKAFLKAKKVEQGWKNYWSTETTDAHRQDLIIGLNGYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C929</accession>
    <name>A0A6A7C929_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C929"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="31"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33975" checksum="E6CF9EE265B1BA7D" modified="2020-06-17" version="1">MQSLRSARVLSQCGRRAFSQSSSLAAAEVKKVGVVGAGQMGLGIALVASRMAKVPVTVVDNSSKSLDKGLSFAEKLLAKDVGKNKITQSEADDTRGRLYPTTSMDELKDVDMVIEAVPEIVDLKKSLFAQLARICPPHAILATNTSSISITLLARATTEDPTDLSAPSRVVSTHFMNPVPVQKGVEIISGLQTSPETLETAVEFCKRMGKIPSQSADSPGFLANRILMPYINEAIICLETGVGRESDIDSIMKNGTNVPMGPLQLADFIGLDTCLAIMEVLHTQLGDSKYRPSVRLRQMVDAGWLGKKSGKGFYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9D6</accession>
    <name>A0A6A7C9D6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_143094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9D6"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="11370" checksum="FCFAFB0A71765A36" modified="2020-06-17" version="1">MLTITNHNCGRSPFEDWLAVAMPNAKAGLQMHLLHLIPSSLVIIMSSSNHVKNVAIIGVSLIFPHLLPLIKYTDSKQGRGNLGSYIITQLLKTGKHTATAITRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9E4</accession>
    <name>A0A6A7C9E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2349068at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="36419" checksum="C850CFAE1C42BA4B" modified="2020-06-17" version="1">MHSKSSYPWTKQPVIASAPMRLIALSDLAASVSMAGGIGFIGAGSDVSNLDSELTRVRQLIDNVPGLHSSQDVLPVGVGFLLWAGEELLNVSLPILAKHKPAAVWLFAPRQSDDLVCWTKGVRGVSPATSVWIQVGTVSDAVEAVKSCSPEVLVVQGTDAGGHGLERCASLMPLFPEVDDAISLLCKDASVDKPIMLAAGGIADGRGVAAAMALGADGVVMGTRYLASKEAIISQGYQTAVLKAADGGSTTLRGKLYDTLRGTTDWPLRYGGRGVLNDSHFDAEKGMGIEENKKKYDEAVEAGDWGRLTTYAGTAVGLVKEVLPAAGITETVRLEAQECLRRTSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I8</accession>
    <name>A0A6A7C9I8_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
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        <name evidence="5" type="ORF">K470DRAFT_85490</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
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    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
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        <location>
            <begin position="275"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
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        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="837" mass="92851" checksum="CEB1ED43623F77C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N3</accession>
    <name>A0A6A7C9N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267692</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9N3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16842" checksum="FA5281D79F219E7E" modified="2020-06-17" version="1">MDCPRKEAPLPGNIHPTRHVYTREFLLRLQRACTAKPRKNWDQTVGKLIISAEDSIVSPPTPRNDTLSQEIKVFSLSRPRQQTQNAKANTTPEDVKQSAPAWKPQRVVAADITKDDKTKTIAAPQYFQDEENPQRSAGQGNNIKGKLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9V5</accession>
    <name>A0A6A7C9V5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4267 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15138" checksum="15B6194B941D71FC" modified="2020-06-17" version="1">MSFQTFRAGLPPPSTAFAIAIGLVDITIFGIAGLANPREFGNAYGLPLGREHDNQQDESAQKKGYILALASRNIQNGVLLLTLGCYLRDRRALGASVAVMAISAVADAWIVGKFGVKEMVWGHVFGFCTAVGGGGWLLRGLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA45</accession>
    <name>A0A6A7CA45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_48158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA45"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="353" mass="39970" checksum="7432DA9558B32D31" modified="2020-06-17" version="1">MASPVVTTTELAAPAIDEKDEYAKFFWTYTEEPHMTRRKAIIKAHPEVLKLCGPEPLTIPLVLAVVLLQVYCAYSLRNTAFFSWPFFLTAYIIGATANQNLFLAIHEISHNLAFKSPMANRLLAIAANLAIGIPYSASFRPYHLTHHKSLGVDGLDTDLPTALEAWFLDSVAGKAFFATFQIFFYALRPMMVYKVPLTRIHALNIAVQLAFDYTIVKTWGGKALAYLILSSFLAGSLHPCAGHFIAEHYVFAQHSKSLERGKPVSPPPPETFSYYGVLNLFTYNVGLHNEHHDFPAIPWSRLWKLNSIANEFYSELPYHRSWVGVIWQFIWDGKVGLWCRVKRKEGGRMVIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAC1</accession>
    <name>A0A6A7CAC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAC1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8476" checksum="A7AFBAB76186FEC6" modified="2020-06-17" version="1">MQFTQVFISLCTSATHPSTPFTPAKDQAKRTQDHQPNNSDHHKILAQARSSLQKQPPLQPCKSPSKDRPLYTSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAS1</accession>
    <name>A0A6A7CAS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_254434</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAS1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="197"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2864105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="385" mass="40836" checksum="0245CCA43AB4077D" modified="2020-06-17" version="1">MNNSRVYRASTFAPVNIAVIKYWGKRDAKLNLPTNSSLSVTLSQDHLRAHTTASCAASFDSDTLKLNGQQQDVSGSRIQSCLAELRRLRHAMEDADGSLPKLSDMKLHVVSENNFPTAAGLASSAAGFAALVRAIANLYELDASPTELSRIARQGSGSACRSLFGGYCAWDMGKAADGSDSVAYEVAPASHWPDMCALILVASADKKDVSSTAGMQQTVASSSLMEHRIKHVVPERMQEMEQAVRDRDFAAFADLTMRDSNNFHATCLDTCPPIFYMNDTSRAAVRVVEAINKAAGRPVCAYTFDAGPNAVVYHLASNRAAVAGVFKLILGGKPGWEGNQGATIGSTAAIPKGAEAAAGVLQAGVSRVILTAVGDGPRKTDQHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBU6</accession>
    <name>A0A6A7CBU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_254224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBU6"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="376" mass="42484" checksum="7BC5ACFB29550507" modified="2020-06-17" version="1">MEAHFLSLGFGGILALGIEVFIYTTVSVTIVFVSKADSTGFVPVSSPRFSARAVASAFLQWLVMLQDGRRRVVVSLFARAQPQYLFAGSSECEEKHILDDRQLIRWWARVLDSVISANAERRCFMTVPGYSAHELRQFYPLGSTSWQPGYPLVEVLGRDDVPIRCLLPRFPDDPKARFMQDLDDEVGLLEGSPSKKRNGQWANIRSLDQFWTAMEFRQECSSGRMVGFIWVLYTPHLALEATPQPSETDRKSSQKKKMRREPRKGPIIPRQPRVKVPAAEEKGPDHALVLSREKYDKAIQTLLTLDFANAEIATQSTRKWAAEVCTMSGLPEGEDFQAEVEGCAAMEGARDQNNRKRKEVNVLDASMVRKRRKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBW6</accession>
    <name>A0A6A7CBW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBW6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="91" mass="10092" checksum="70CA76133B4AEBDE" modified="2020-06-17" version="1">MDNKHYRIGMSVLSIMAKVALNCKYFAWPMSECLEMNEASHIVLQIELTASNHSVLARFAKGFVALTVFETNTPIGPCCQLPVSSSFRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CC54</accession>
    <name>A0A6A7CC54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CC54"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="81" mass="8757" checksum="DCF0B4FF6A08FEDE" modified="2020-06-17" version="1">MGGRSFFIQTRQSSSLPIKGSLSSHEQCSQDRSATHFLSHTRTKHPASAVPFVAIGIIIMAQQAPYPANALHGLREADVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCZ0</accession>
    <name>A0A6A7CCZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_224141</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCZ0"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2864278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="17185" checksum="F06776761DAF41D8" modified="2020-06-17" version="1">MSTPARRRLMRDFKRMQNDPPAGVSASPIADNVMTWNAVIIGPADTPFEDGTFRLVMNFEEQYPNKPPVVKFISQMFHPNVYASGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNTSSPANVEASNLYKDNRKEYTKRVRETVEKSWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQV2</accession>
    <name>A0A6A7BQV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_273176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQV2"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025612812" description="FZ domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65308" checksum="3094B6C0C0BCE714" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR43</accession>
    <name>A0A6A7BR43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_237956</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="MU006032">
        <property type="protein sequence ID" value="KAF2857680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR43"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="207"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2857680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="483" mass="53355" checksum="53D9132FDD4C52C2" modified="2020-06-17" version="1" fragment="single">MASRRLALGLQQSARTQRALNSVRSHAKLGLTRGLATPVHTTTTESTTLANGFTIATDHSPYAQTSTVGVWIDAGSRAETDRTNGTAHFLEHLAFKGTQKRSQSQLELEIENMGAHLNAYTSRENTVYFAKAFNSDVPATVDVLADILQNSKLDKGAIERERSVILREQDEVDKQTEEVVFDHLHATAFQGQPLGRTILGPRENIKSISRDDLVQYIQTNYTADRMVLVGAGGVPHAQLVELAEKYFSKLPATNPDAQTGSFHRGQSSKPDFVGSEVRMRDDTMPAAHIAIAVEGVSWKDDDYMTALVTQAIVGNWDRAMGNSPYLGSKLSRFVHEHKLANSFMSFSTSYSDTGLWGIYLVSDALTRLDDLTHFALREWSRLSFSVSDAEVERAKAQLKASILLSLDGTTPTAEDIGRQIITTGRRMPPEEVERVVDSVTAADVKRFAQEKLWDKDIAISAVGPIEGLFDYSRIRADMSRMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR96</accession>
    <name>A0A6A7BR96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_260841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="MU006045">
        <property type="protein sequence ID" value="KAF2857407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR96"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="763" mass="84261" checksum="696883B1D8C767C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR98</accession>
    <name>A0A6A7BR98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_238687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="MU006053">
        <property type="protein sequence ID" value="KAF2857285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR98"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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            <dbReference type="ARBA" id="ARBA00049348"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857285.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRJ6</accession>
    <name>A0A6A7BRJ6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="93"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="434"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="50494" checksum="94949A8116116E16" modified="2020-06-17" version="1">MDDGSAWETGTRPKDNKKSRGIIEVLGGDAEASVQPALVQDQDNNTTWNKFGTVGKKERIIGKKAIGEEEEWTVESLIDDPTSAEPVKEEPTSSGIMSSMWSSLGVGKSADKTKSRAAEKKEKEAAKKAAKDAADKEAAEKAEKEAAEKVEKEAAEKAEKEKAEKEAAEKAAKEAADKQKADEDAFGAALDESHTDFLGVGTSAAKKKTTIKKAGTKETKTKSVTEPAKKTESAGWGFLGRGSKTATPKEEVVPDILAGVQAEEDMLDFSAPANIEAINVKPKEEEKKAKSKEDDKKAKSKEDDKKVKMKEEEKKEDKKVKINEGEKKVKIKEEDKKTKSKEEEKKAKKAAEAASAPSTPMEPVVEKKSKSKKVVEAAEPPPPPAPPRSPLPGEFPLEEAAPPPTPGVAAVVDEASKPSKRSEKHKSSSKRASKVAEVEAPPKEKKPRVQLMGILGCNLPSPKDRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRJ7</accession>
    <name>A0A6A7BRJ7_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">K470DRAFT_260430</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the UPF0507 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1258" mass="138676" checksum="6E943899ABA931F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRK9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857871.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="258" mass="29084" checksum="A0AEFD637F9F88D3" modified="2020-06-17" version="1">MDTTMSTPSTTQPSSTRQGRKRGMLFAKDARSDRLCTCQVCANRQSENKRDSRGYVSDSSVPHIYMERFEHKVPRKVPYEMKSVMKKYVVYARAKHYDAVLPDKALRTNVVDHYGCLFRSYTRGPFRNMCAHEHKRVCIGPELSLATLDMADSPAATGENYIHFTYFEQDDPESFMISHAGQSHVMTFVENCSTGTIREVAQSLYVHHIRLGTLYDYVPRLVLDGMTVDMHKVGQTTRFGLCGAGSPSQCLSVVGEAS</sequence>
</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <subcellularLocation>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="12"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="110" mass="11742" checksum="151F26B78B1628DF" modified="2020-06-17" version="1">MLTKRRAVSVAGIVLPLLLAITAVILCVLGIYAGAKKHRAEQARGRQQIEERRASRRLSNGLPDWWGVKADVRGLEGGVVPAAGGGIQPAMVLAAPAASQKLHTMRKTLR</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTJ3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="233" mass="26002" checksum="8131767201CADB45" modified="2020-06-17" version="1">MLLDTPISRRRQLVSCSNSYMSCPLCSASYQSGSSDRPLWPTHINAGAELATLPANGSRDWQNICRLAAPAVLLFLTRLLVPCKVIVYLFLTAKIFWFGRVLRVRFDNNGDLTLEKVPARALKPGDLIRIRDRQPLTSDVLFICNVSSLRDHAAIHHQHKSIRNGAKSLPIQVAVPAIDQDALAINDETWINGHLLTTKYKSSVGYLATHCFQSRAYASVISPSRVHWLGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ0</accession>
    <name>A0A6A7BTZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_288850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTZ0"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25867" checksum="422F754291AF1B38" modified="2020-06-17" version="1" fragment="single">TTARSVRGITAVGLAFKSPLPPQQHRNLTAATMANLRTQKRLAASVAGCGKRKIWLDPNEVNEISSANSRQTIRKLYKDGLIIRKPVAMHSRARARELTAARRIGRHRGFGKRKGTADARMPSQVMWMRRLRVLRRLLVKYRAAGKIDKHLYHELYHLSKGNTFKHKRALVEHIHKAKAEAQRARAIKEEMDAKRAKTKAARERRQERVAAKRNLLPDDGEEPVGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU93</accession>
    <name>A0A6A7BU93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_118554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU93"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="24812" checksum="836BF1F25D4DDBBC" modified="2020-06-17" version="1">MNSFRPESTFGHNGNECRKQCYRSHNKNRKKRGPALSQWDDVEKAVRNWNKEQSDDPLEAKETFSTDSFPVFFPPSALEAPNRNGLNSAVRNLRNLVVGADGRFFNHSAHPDRNTWFFYCVQDRDHPYASKSRNIRDAFLEHRQNCGSMLCMKLSNDRQVLEVLLNYKHHPARFEMRMTDECKEFSAMTNVERLGYRKVLAFLGSSAPCGGKCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUA4</accession>
    <name>A0A6A7BUA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_272175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUA4"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="620"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="668"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="800"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="937" mass="105442" checksum="09360EB397E7266D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH6</accession>
    <name>A0A6A7BUH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUH6"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="15844" checksum="02E5F9BA89F9E096" modified="2020-06-17" version="1">MSTITRTLRNLWKGGIKQYGHNLQYIGDTKFGTIVGTDKFGNKYYENIDELPLRTRWVDYKDKEFDPSQIEPGWHAWMSYMVDKPPTEDKLLQREVRAWEPKEHLPSMTLSRSAYRPYSTTKSKNSAWQPVAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUI8</accession>
    <name>A0A6A7BUI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_200089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUI8"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="492" mass="54035" checksum="4CFED1B0953966F9" modified="2020-06-17" version="1" fragment="single">YGNLVDFTLAGTYDPDKPVIIDAETPSRTISLRQARDGVEYFQRFFSPRTTVCTHLQNDVNYPLYVLGIMAAGAIWTGTNTSYTAAELKHHFTTSNTTCVITEIEHLDTVQAAIHASGIKIKILVASDLANSAVKMRGPRPYICPTSTAVMMNTSGTTGLPKIAARTHRAFLAELLGTGALEGVKHYEVRRLFCIPIFHGFGAPEMIFNALHYGHVSFFMRRMDETFAQKVHDFGITETYGAPPLMLRLVNDPSHHHLLQSLRRISFGGAKLTPELRKQTLSMFKIAPRIVPVYGMTEGGWFTTCQGNIDDEGAAAGSVGRPIAGITIKIEGQFRLSDGNTGGEIMISGPQLMTAYFRDQAATSETIINGWLRTGDLGYIKNGHVYLIDRLKDLIKISGFQVAPAELEEVLRRHSGIVDASVFGAGVDVDEHPVVCVVRRPGASNTSVAEIKAHLRSQLTRYKVNRCEIVYVDSIPKSAAGKVQRKALREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUR8</accession>
    <name>A0A6A7BUR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUR8"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="401" mass="44464" checksum="408957DCA6E2B4C9" modified="2020-06-17" version="1">MATRESMAESLKTELKAWEREFFAANGHKPGKDDIRKDATIRDKYREYERLRKPQTEAKIETKPSLATPRKKTRPAADFALKERCRNPILATPRKEKEVADEEDEVEPTPAYIRCALGPTPQRDGQVLGIFDIHPFATPAKSIAGTPSKAAPVKDLMTPSKSTAATPSSKRKASALPDCTPSKRKLEDDEEVAKALFETPAFLRRTYSLPATKDGLYVPSPPPFKKRKGPVRSLSSMIQSLRKQEEERMDDELDVLNEMEAEARGEPVHNKPDGKTEVEMPLGPDGVVDAQKEPEGDQSGGKPFKKKGLKRQTKRAIMRPVLHNPTKAVEVQGAEADNSADDAEDNIAKQKAKTTAQKGVKAVDKAVKKVSATAHANFRALKIKNKNSKARGRGRFGRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVA7</accession>
    <name>A0A6A7BVA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_109860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="728"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="263"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143296" checksum="155CB9604266CF42" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29078" checksum="7AED0F7CD652A539" modified="2020-06-17" version="1">MDANNTTNSTGDPFESAQSRKSIWIGLLWPALYLTILIGSLYAFSSLHRKRQLAKSTRLEPWFPPHRQRDIYLSLLHQEADGTDEKQAQRAPDSVLAAALLQRAFEDIKRIVQLRTSKQALQMLLQRGSVGEELWQRYQHAEQEMEAELKDVIEEDQANGIAPNWGNFIFQSANEMNQNRLLRERIEDAQRPLENERQWWANKKSGMAAELMRELDEDGNSSEAKKATTSDDDAVLVESGGPTQAQGSGKKKKGKK</sequence>
</entry>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2858789.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1215" mass="127038" checksum="1D1B212CB119818B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVN1</accession>
    <name>A0A6A7BVN1_9PEZI</name>
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        <recommendedName>
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    </gene>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="22983" checksum="842291D61A4A8784" modified="2020-06-17" version="1" fragment="single">RIETCHFCSHPVYPSKGMTFVRNDAKVFRFCRSKCHKNFKMKRNPRKLAWTKAFRRAHNKEMTVDSTLKFAQRRNIPLKYDRNHTAETLKAMERVAEIKAKRSRQFYKNRMKSNRAEQLAADRKLVAEYQHLLPPKYRDIKEVDMMDEQEVAERMDAVEESILEEERLREEARQMSRNKAPQKMKVGGEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVZ1</accession>
    <name>A0A6A7BVZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_249299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVZ1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="16949" checksum="E9C1D84DF7632653" modified="2020-06-17" version="1">MPTRLSKTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGMRHFHKLGNHYWKPVINLDKLWSLVPLEQREKYLAKGASGDTAPVLDLLPLGYSKVLGKGRLPEKCPLIVRARYFSKDAERKIKEAGGVVQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW43</accession>
    <name>A0A6A7BW43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_265838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW43"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025430672" evidence="2">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="498" mass="49606" checksum="1E20453A74D264A9" modified="2020-06-17" version="1">MFARILVGALAGSALVNGQLTGLITPTLTVPTNIGNAVSSLVSAQTSALSQVNSAYQSVATVSPAILSDVSNAVSSLAAAPTSLVSALTDAVSSLVALPTSVASDISSLVSSLGTTPTTAAGDAASIVSALAALPSSLLTTVSDVVNALVVVPTGLIDSIVQAVATVVKDPLCLATLPSTFTQDLQLVIDSLNALVGCLLAEIQALLKSVTDILSLGLPTTGAVTDAILQQVIGTVQTILSLPSSSVDTILQRVVALQSSLNGTSQCAPISLGVSSLTPYTSTVTISSSTTTTLPAETTITTTLASSESSAAATSGEASDATTSSEASVAATSSETSAAVTSTVTAYITIMAPASTVTESVATVTTTIPVTVTATTVLVTTSTVTLVSIETETQVTTVTVTRDLSTPTPTSVTIATKLITAYVEQGDDSMPTSTTTVAPSQSSCETEQTGVSIAGYCVWNCQGGAKTTSGKSKKSAGASNRIEKGLMVMGLLLSFAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWE4</accession>
    <name>A0A6A7BWE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_287786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWE4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17168" checksum="31B068083C875CF0" modified="2020-06-17" version="1">MSVPSHGQTALIIWDKAPIQHKFNIVAVDTTWGTYWIPIIFPAKNVRACAYYFRADEMSSSESIRRCTLCPTMARKRCETGHSNLMEHITRAHREWESVVERYIAMSHKLEFNNRPTPRSNIQYEWMRWVFDECLPISFVESKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWF1</accession>
    <name>A0A6A7BWF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_249012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWF1"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="51942" checksum="18C01677514F126C" modified="2020-06-17" version="1">MATDRTPSSHRREPSLHPSPAVSHRSSFAENLRGNPRRMPSFTGGLNDLLMYPPTKDGAESRFRGRDWRSVQVSEIIDTADARFVELDTSIEETTKLLIRSGSPNVVLVRESHKTKTCIDTFDYSDLNAYLLLVLGLSSPPESQDMVRRARGGEAIPLRDLLHHLGPREPPIAMPRTADLTRAMEVLGSGMHRVVITKEGTSEAVGVLSQLRLVRFFWDNDQNFAATSDLYARSLKELQLGTKDVMSIGGDRPLSDALLLMHEQGITSLPVLDAQRNVVGNVSHVDVRLLTDTSSIPLLSSSCLHFISVILSERGLEDGKDSYPVFYVTPLSTLAQTVAKLCATRSHRMWIVDQQASPSGSVPPSPGIVASSGPPGTPMARRASHDIGSTAPPTIIPGASLSGRLSGVVSLTDILNLFARASGLSPCDPDEIRKRRRRSSSSSQRPNLDSVRASMERPRGDSSAGRSSRSTSSNRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG5</accession>
    <name>A0A6A7BWG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_282894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWG5"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000021">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="199" mass="22563" checksum="FA808C376964F4BB" modified="2020-06-17" version="1">MAQGDLWLFGYGSLIWKPPPHYDMRLPGYVTGYVRRFWQASSDHRGTEEHPGRVATLISRPYWEKLTDGHTSAPERTWGAAYRIPAVHVAEVKEYLDIREINGYSVKYTDFHPSSDAAIPAGVDVPIKCLVYIGLPTNPQFLGVQDPQKLAERIAISRGPSGENREYLYQLETALEALSKDSHDQHISDLVRRCKALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWJ2</accession>
    <name>A0A6A7BWJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_300455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWJ2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="114"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="51990" checksum="AC02CF0894C808E5" modified="2020-06-17" version="1">MSQTFSQYKVQRISFPPRSKMSLKLKGPKRPAGDSQPESKASSPMRAASGGPKLKLTFSQPATPVEQTGGFPEGHQPRKKLSITTLNTKRPPPPRPHGVGYDSEESDREEDPAIQQGVILRMQPGPDAELVRAAISNNKIGSKEELGVDVGLRFLTSDFRRATLRVQNRLYAAVLVDLPCIIESMKSWDRKGWWKVADIHQMLLVLGRVQSDEEAKIYPLPREVDSEKMQYPHGLTPPMRYVRQRRFRKRMGNKQVENVEDEVERLLREDDEWESKYKDAKITLKEFTPAEYERHMEVEDMEMDNVVQSPDAIDEENEDEDDVAFQHDLEAAFAEAADPHAGAESPLVSATGFDSPVAFADGDIAMAETPVETSTPMHDEESESESEEDDYDDEDEDAAAQAAEKAQQLEEVADLEREIEAAKVKANTMTNQLLKRREMEKIAKLGDDLRMKKATYGLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR9</accession>
    <name>A0A6A7BWR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_94773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWR9"/>
    <dbReference type="OrthoDB" id="3792237at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17366" checksum="FC612819CB759145" modified="2020-06-17" version="1">MATALGYLHEEKLVIHRDIKPEDMFLKFSTPDDVPPVLVLGDFGLSSPMNDTHGVSGSPGYFSPKCKQSLSLEEHARDKGVQTPKLDMYCFGAVLSCLLTSELFDNRREESKSHLLRPKLARAKAPDNTREFTIRCLSEQPEDRPETLEFVQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX13</accession>
    <name>A0A6A7BX13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX13"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="54380" checksum="A568294F5FD6DDFB" modified="2020-06-17" version="1">MTFLYFLAPIVALVAYIGYNVITDPLKGIPGPLLARWSRLWLVWHSRKGDMPTVMIDLHRKYGPLVRTAPDEVSISDLAAVKTIYTPGTRFKKSEFYRPFNNDREFDLFGGRDERLHAQQRRLVARAYTMDSVRDNEDGVDSIIRIFLKCIDNHAGKKMDMANWLQLFAFDVIGEVTFSKKFGFLEAGKDNGSFAHINAALKSASWIGMVPQLYAINKLIQPYVGVLVDSDRSFGPMMNYAMSAIRDSQGEKNILGKLRAVHKEKPNEFTFPNMANMAVSNLFAGSDTTAISLRAIFYHLLTNPEHLQKLLHEIDTFAAAGKLSDPVQYSEAEKMPYLQAVIYEGIRLHPAVGMNLPRTVPEGGMALAGVFFPENYTVGANPWVMHRDKEVYGDDVDAFRPERWLGEGSSDMLRYYMAFGMGARGCIGRNIAWLEISKLVPTLLRRYEMEIVDTKWEYDCHFFVVQRELNMKLTPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX56</accession>
    <name>A0A6A7BX56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX56"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="261"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="620" mass="70111" checksum="E9AF26B5D808B995" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX83</accession>
    <name>A0A6A7BX83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_248965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX83"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="28078" checksum="35F3E99F36F890EB" modified="2020-06-17" version="1" fragment="single">MLVEFPLIEAYNFVRPSDADVLVVRNVPLDAMKQDVLKLFDNMPYQIVEQPIGTGYRAIHLVPCHRSGTKLSAYVEFRTPCAARAITKHFINRAKATSSGAGGGYYIGGNRVRVYVTTQSELMAALFPWARGVLWVGSIPHISPKQWNTPTGFRGFMHEAETNAMSRAYHLRSLEHCISIIHKYPWGAAEHIFLLERDALFTTAKLILSLGINSLVAEPSSMPKSSRTRRVVQELAIAIFTCPGFNEAQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXH2</accession>
    <name>A0A6A7BXH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_258891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXH2"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="514" mass="57235" checksum="81812BCE2EEE5E93" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXI5</accession>
    <name>A0A6A7BXI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_277921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXI5"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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</entry>
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    <name>A0A6A7BY88_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="Pfam" id="PF12896"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2860174.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="741" mass="81071" checksum="2913C966DC203E02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX7</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2860441.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="181" mass="20094" checksum="BC231AE5F8AFAEB4" modified="2020-06-17" version="1">MNSIGHSLRHRSRWAAEKETKIEDTCILKTILGLGHSHDANVLRLMLEAVYIKEKYWSASTISSTPQYATPSKDSATPMSYKTPNASTFSGGEEKLDTSITITDMCGCTNNSATKIYSECEKVKAIGISSFLKSGKRRATCNAHRGVTHLKHSKAKEMKPHLAQPKNKRIFVWENVPLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ14</accession>
    <name>A0A6A7BZ14_9PEZI</name>
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        <recommendedName>
            <fullName evidence="14">SWI/SNF chromatin remodeling complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_217030</name>
    </gene>
    <organism evidence="12 13">
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="190"/>
            <end position="357"/>
        </location>
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        <location>
            <begin position="578"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860481.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="90983" checksum="4DE46B47B26C177D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ22</accession>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="174" mass="19141" checksum="25E070B9408C824A" modified="2020-06-17" version="1">MSTICKVCGRRCTSRKDLEFHQVIVHAGEANAASESPTKGTHDDNSGKGKDKGTGEKGTTTSMVSVAEHNDPRKKEGTVEDKVNENVCSKSSLPEGSAESAVSATDFDDPRLETQLEFQAALRQHRQWVSHMLNTDGIQDRDDIMEESLHHQGGLWLEEELMSDGPQPVLHNET</sequence>
</entry>
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    <accession>A0A6A7BZ70</accession>
    <name>A0A6A7BZ70_9PEZI</name>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="19" type="ORF">K470DRAFT_282014</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
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    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
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        </reaction>
    </comment>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="RG7MT1"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="PANTHER" id="PTHR12189:SF2">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
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    </dbReference>
    <dbReference type="Pfam" id="PF03291">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="97"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <end position="401"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
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            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="45"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51562"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860530.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="538" mass="60752" checksum="D24A7917C58C73DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025646872" evidence="2">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17716" checksum="8554D117B607C1D4" modified="2020-06-17" version="1">MILALMTAVFLPGSDGSRRSKRDSFRMPCAWISPPSDPAHSAGLGPQLMILTPRPSWQCPQTCKSGLLGPKLFHQRPTPATIPMTTFIAQPFCWDAWNYDVNCQRYHGPKAVCVCVCVCFCFCFCVSVCICICMCKFRWALKRPARCSTFPRWRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZX2</accession>
    <name>A0A6A7BZX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZX2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="8430" checksum="B3C37D808B954F73" modified="2020-06-17" version="1">MKTSHSSSYPLIVGTLAVEGSANFVAMLWIHLMRTGTTFIFKMLVYCVRSTKFFKVVRCIRMGYYPRRTLCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZX6</accession>
    <name>A0A6A7BZX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_199980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZX6"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="232"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="50394" checksum="520EC5A26C5E1B58" modified="2020-06-17" version="1" fragment="single">SSYYTSRPRFDRLGNPMPDHSTKFALPGDLGPSDPRWTDSPASLPGDLGPNDPRRSGSPHVTITSEETPKEGAIEGAASEGDGDGDTEGEEGTRGRGRGRKRPEPGVTTSGKAVNVQNEDDDESPKVKPDPTKGESKFTGLRVPKIKTPAAEGKRVHPSTAFDAAPSGASTPFGSDDERRSELREAQKLTLTMSAIHNTPAAHRVIRQIIRGDYVRLQQEAAAGKRRQRMYLVATDLSPESEYALEWTIGTVLRDGDTLFAVYASDLESLAGGADEGGVEIGHGAEMVKDTAQIVNALPNANVPQSPGPSNLAPRSLSRGQFSPAVSERYRAIEDISQRCIHLLRKTRLQVRIVVEVFHCKSPRHMMTELIDYLSPTLVIIGSRGRSAVKGVLLGSFSNYLVTKSSVPVMVARKKLRKHSKSKRNKDGTLNPYAGTGRSGMFTNVIQAPKRMGLRVQGWDQVGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C005</accession>
    <name>A0A6A7C005_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_276578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C005"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025620181" evidence="4">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="379" mass="39869" checksum="B742222661A80A42" modified="2020-06-17" version="1">MLFNVVLATTLASLGASSPTRVPLRQHPAQPNAVRPVVHALHKHAYKGAVASKPAPETLDSGFWFGSFDVGNAKNLSLLIDTGSSDVAVNPGLYKPGSESSDLQHAGDLGYATVNVNGCGKAKIHYNTFEDAVTQGQLTAHKQALGNIVATPPPDNGTITTLPHDGLVGFGVPQAGQTQMGGKPFFSSLCEQKSVDKCRFGLAYGTDGTGAQILGGVDNSLFDGDLKTSSSDTTWNAQCSVKINNKDSVSENQKVLFDSGTANVVGPPSQVRQLFSKLGIQAVEQNLPGCTSVLFGYYDCAAPPTVGFTIGDETFNIAASAFQQAKNGPNNCTAVITGIDFGSDFWIVGQAWFQGKYVDFDVDHSQIGVASLRKAHQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C034</accession>
    <name>A0A6A7C034_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_232048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C034"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF404">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025705119" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="712" mass="76339" checksum="8B9DA859D5A1DBEE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C083</accession>
    <name>A0A6A7C083_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C083"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="8302" checksum="8EE5CDD19E5CDF5A" modified="2020-06-17" version="1">MSATHHCPSRRQSNAKDLDFDQEFRQAFPQGTRKQYPHKEVSRSYQFVTELRGKGSISPNNEDNPNCYLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0U7</accession>
    <name>A0A6A7C0U7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_276730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5367052at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="49074" checksum="3CD9986BDFFF5971" modified="2020-06-17" version="1">MPTLEPYNPQEWSQRSRRPYPQAVSGTAASTRDLTGMEDVLPPPAPPYSPRDQSSTHDASPREMIDCYNPLDSPPTFSQVSSFPPPQAQYDRRSRDLTPSTNRLLPNGQRQQPSNSLSISAALTPTASRRATSMGPAASHMSTLKDWPSNVPLPPPPPGPPPAGPRSRSLNRYSTSAIHDRRDAENVPSRGAAVATNLVTIPPTPTDESLTMDEALGEDQGFEWDFLRNDSEPGSLYRRTAPREVTGETNDRRPRGQRAQSTDCGLDRARALMPVSSGSISRRRSKNRVLSDLSTTDTNVEARRPSPGPASTANVLTPPYTPANDFHNLSQRRMAPDSASSERFTSQIEMPLVSAGPISALESTRLDAFALQAIKRHRAFIEKEAAAASDEERLRLFSKYIVNESRLRRDRYASTYAGMAGEIVDLMRDMWRSYHVRADCSCSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0X5</accession>
    <name>A0A6A7C0X5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_47298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0X5"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="38"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="372" mass="40916" checksum="C2BF7BCA291320C8" modified="2020-06-17" version="1">MLARRVLRALPRATNARSYATTLETDASKVTKYGGRYTVTLIPGDGIGAEVSESVKTIFRAEAVPVDWEQVDVSGMEYGAKHSEDLFRESIASLKRNKLGLKGILHTPVERSGHQSFNVALRQELDIYASVSMIRNIPGYDTRHKNVNLCIIRENTEGEYSGLEHQSVEGVVESLKIITRAKSERIAKFAFSFALANNRRKVTCIHKANIMKLADGLFRNTVARVSEEYPTIKTDDMIVDNASMQCVSRPQQFDVMVMPNLYGGILSNIGAGLVGGPGIVPGCNVGRDVAVFEPGCRHVGLDIQGKDQANPIALILSSTMMLRQLGLEDHSARISKAVYDIVAEGKVRTRDMGGDSTTHQFTRAVLDKLETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C126</accession>
    <name>A0A6A7C126_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_281669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C126"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="27"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="493" mass="54517" checksum="AAC8FD965FA0DD7E" modified="2020-06-17" version="1">MAYPGSLERPNPTLLRSREYPQLTQCTYLDNAGTTIYARSLIEEFSADLVQNLYGNPHSACAPSMFCGQRVDAVRAKALAFFKADPEHFDLVFVANATAAIKLVAESLRGYATARGTQLWYGYHKDAHTSLVGIREVVDLSRCFSSDAEVEEWLNSRGPQRPLRLFAYPGQSNMTGRRLPRTWPARARAMRYPAYSLLDAAALASTAQIDLSDPHTAPDFTALSFYKIFGFPNLGALIVRKAATHALHHRRYFGGGTVDMVVAVDDTWHALKDTSTHDRLEDGTLPFHAIIALDHAINVHKRLYGPEPMKFVSEHTSDLARQTYEALAGLRHANGTPVCRIYTDASARYGDALTQGATIAFNIRRSDGSMIGYEEIERAANARSVYIRSGSLCNPGGVATYLGWTAPQMRSAYAAGHRCSKPRQIVAGKSTGVVRISFGAMNTIEDVQALLRFMNIYMSVLRVSHSPPNPARNTFSARRFGRSLADKFKPLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C158</accession>
    <name>A0A6A7C158_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C158"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="40424" checksum="50DDF7402D494192" modified="2020-06-17" version="1" fragment="single">QFPRDPNTRSNAWPGGRGGARGRRKGGRGGKRPLVEEAQSVPNLKRVRITAERPSANTHDSYEEFGYVDGEVDKDYEDNDHSVDEDLIDDEIRDDLCHIGNANHVDFVEDVEDGDNLTEMRANIAPSVTHPTPLPKSVSIRRVTAPLGLSAPRAPPAGTPVPSMSDDPLGIAGSLSQTARVRPSRPTMTTADAVSRVRAADTSSHFLLEDVVELVTMNKGLHTGLQALEARVNEMRETRVANGGIRAAMRPLLFWEHAWGALWGDKFAIAAELRSRGVMVKAPTQSVLSEIPQVKSDVRQDLRKRLRDVHEETLQRAKAASLWKLKVSQYSASRADSLEQWDLNYHLLSADNKRLIFERDPHSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C174</accession>
    <name>A0A6A7C174_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_294932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C174"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="408"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="770" mass="89533" checksum="FB530FDE383E0A0E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1H9</accession>
    <name>A0A6A7C1H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_299297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1H9"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15200" checksum="1461FAA54E874924" modified="2020-06-17" version="1">MSSARFWQVTGLAAAGGVGYYLYQSGGSAKGAEKRAEADAAKLSREVKGHLPGAGKEAQKQGEVFAADAGRKLDDVVASAKDGVSNIDRKLEQYRREAEKNIDGKMKEAQDKANSAIDQFDKRVTDGARQAKSGVSSWFGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1P2</accession>
    <name>A0A6A7C1P2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1P2"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="28116" checksum="421DD3DF96A1A57A" modified="2020-06-17" version="1">MPPTLSDEEVASMLVDEADSAASRRDKNAPRPNMTFLKNLVRNADSHNAALRRARERDAARARRDGDKKIWESNDRRKLPSDRDRADRWMRTLPRLSNSSPKRPAKDDKSKYCAKRRRTEPCHSSFDPPPRGRGAYRSSNHIDSRFASDYNPETDYGDEDDNGEDSDAATEAFRLRKAWEFQQANRLRQAGFTDDEVRRWDDGGREKDVNHVQWNKRGQSREWDRGKTVDAEGVVTVEPLWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1U6</accession>
    <name>A0A6A7C1U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1U6"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
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    </dbReference>
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        <property type="entry name" value="GPI2"/>
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    </dbReference>
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        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
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        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="148"/>
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        </location>
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            <begin position="151"/>
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        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861546.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="43145" checksum="63898D68F4FD599A" modified="2020-06-17" version="1">MQPRTHPTEQIYLHPEDAKSSRPRKSSPLRRTSIPPSTQKKSKNHRRHRPNLPQWKKLLWVKQNFPDNFTDEDTFLDHLQRNPSLRPYEFWELVADSTVIVQHICSVVIFVCCFTAIFQERVSPQTVVWWATFGTVLAWGGRDLWVGDEGPEGREGHGEHGEQGQGGMKFTTDTPSTTENASTMGSNGTPPSLVPSRMQYRLSTAKSAVLIYCFLLGLSPILKSLTKSTSSDSIWALSSILMFTNVFTFDYGAGPEAKFPASLSTNAALMASTVLASRLPSTTHVFSLTLFSIEVFGLFPVFRRYLLHCSWRGHVLLTAGLVVGASGGLSMTISGRGIGVGIVGVVLGGLVTCLSMGMTSWWLIGLQRYKNEIHGPWDPARPVIGRHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1X6</accession>
    <name>A0A6A7C1X6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_42854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
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            <begin position="325"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="481" mass="54232" checksum="ADBB1E88349A5C85" modified="2020-06-17" version="1">MAEQCIVCLNDLRGSESSDAPPVVIESIQSVDCDGVIAHVLPCKHNFHDACLAPWVERANSCPICRSKFNKVELSHVVGGKVLSSYTVEDKKQEAEVDASMLPNVIEDELYAIEHWEQCVICGVSDESIEHTYCDNSSWTCNDCSQSGVHAQIRRYARSNGYATWTHIWQEVSRFRDIDLGFDLDRNPSAQQLLELERWRRRLLIARTHPATAERLRNMAAARLQPQPASDCTEELRAWSDFDKARTSLESHATNQRKRKATSPPESPREEQRPRPPLKRARARRIPVAAEASEPGPSNMTLPCENSTFLTSLLKDVEKQPPMLHIPREQPASRDYSPTRSPSSSGQSTPRMLSPSPPPLSSSVLPLSPMSSSPFSACISDHGRRQRGRDISPSPCPPTHTLSFSSKEEVQRMVKKSLRPRYQEKEITKDQFTEINREVCRKLYDRIGSASSLASETERSKWQEVANEEVRVAIQALHLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C229</accession>
    <name>A0A6A7C229_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">K470DRAFT_246666</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2573941at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25880" checksum="234A536301756403" modified="2020-06-17" version="1">MPPGGSKSIAALNKAELAACVAPSASWHTDYRDTAYIYIGNLPHALSEGDIITIFSQYGRPVHIHLARDKETGKSRGFAWLKYYDQRSTDLAVDNLDGADVLGRGIKVDHARYKLKEGERETVGETDQEDEGGSDGRGGTPERRVEDVDNEDPMMGYLRERERERKGRDALRKRGGRDASRRRRTEKGRDESRRRRRRRRSTSPLGSSDSDERGYRRRRRRSDSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C232</accession>
    <name>A0A6A7C232_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_269962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C232"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025504047" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="516" mass="57331" checksum="685EBFFE0F15E86E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C245</accession>
    <name>A0A6A7C245_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TATA-box binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_276505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C245"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00652">
        <property type="entry name" value="TBP_TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="230" mass="25131" checksum="B1AB61BCAA63F703" modified="2020-06-17" version="1">MSNRADLTAALCGSHEDVAKAVGKKYLFKLAAEASVSRVPGEPVPPVLHNVVGTVDLDIIIKLQTVGEKAINVEYNPKRFTAARIRLREPKSCTSVFTNGMLVVAGATSRANCRLAARKIARMMQKIGFKPYFLDFKITNMVANAHLGYRVHLTALKASLEEHVSSCFFEPELCSGLTYRLAKLSVIVYATGSVLFSGASSEDDIMEAYNHITGVARSFRLKDGTNIPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C260</accession>
    <name>A0A6A7C260_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_257033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C260"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="892" mass="99800" checksum="BDAE44F55EB9AD7C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2G0</accession>
    <name>A0A6A7C2G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2G0"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="37828" checksum="7053A037CF445D14" modified="2020-06-17" version="1">MSLVAGPGRGHQKTGELKLAVEEHVSYIQSLNERQNELEYHLTEHLRIPGIYWAVTVLHLLGRPDALNRKDLIHYVLSCWHEEGGFGAAPGHDVHLTNTGYAVQILLMLNGLEELESQQPNSISRIGDYIARLQQPDGTFTGDTWGETDTRFVFLALYTLSLLRLLPHQRPEHPPLINVSAATSYIRACQNFDGAFGVFPGAESHAGQVYTCVGALAVAGELESSLGKAGKDKLGAWLSERQLPSGGLNGRPEKLADVCYSWWVISSLAMIDRLHWIDRSKLTNFILQCQDPVHGGLADRPGDMVDVFHTNFGIAGLSLLGYPGLAAVDPTYCLPVCVLDQALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2R4</accession>
    <name>A0A6A7C2R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_256612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2R4"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="317" mass="34415" checksum="49350EC781EA51C4" modified="2020-06-17" version="1">MDPAGLTAYGGAAAGHEGVLADASGEIIVKPCTQAEADFYQETLLQHEDFTRFMPSFMGTLQLGAPANVAKTAAAQEMVAENAGSEVLPGSKAHSKQLFGTKIKTELAIVLENLEHGFKHPSIMDIKLGSRLYDDDTAPDKVERMKKVSAETTSGSLGFRNTGMRVWNGQTTDVYDKFYGRQLTAENVGESFQTFFRGLKAELPASAAARALKDIEADIRELRKALETKESRMYGASILVVYEGDGSALREVMADQPRQTSKEAEDSEDEEAPPVTSKVKLIDFAHAHWTPGQGKDENVIAGLINVEKQMQALIQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3J9</accession>
    <name>A0A6A7C3J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3J9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="19567" checksum="BEB684637D5016F5" modified="2020-06-17" version="1">MFLQNPIDFLRGTANPPSCREQILPPAAAGAASVGAPVGGKLTMMHDEAVGIPPNRSRPSVHPTRPPETVQGPLRDLSKPGNTCSFHQPSPSFGQVGADTKNMIQCLLLLPVGARRVYIGDANPGQPLVKPQVLCAWQTLVAVPPSAVTSPSNVCVRGPDLAKGSFDVNCHFVVPALHGFLRSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3K3</accession>
    <name>A0A6A7C3K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_263029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3K3"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="213"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="648" mass="71800" checksum="9810C546E062682E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3T5</accession>
    <name>A0A6A7C3T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_293713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3T5"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="247"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="56017" checksum="7CC420F8C1ED902A" modified="2020-06-17" version="1">MEVDMVKTEKDEEAVAPAPDVTASHIILNSFGLIHAAINSFDPRFTLRALRSISTVRKAPDFPNALAAGIRIAFPKPRSAARQKLEEMLPADAVGDQSGASTPTQSVPDVAEMVEVWAYLGLLVQVYLYDSQQFEKGAQFSSDFVDQIRSLNRRSLDAMGAKAYFYLALFFEQLDPKPPVKHARATELRPKLLAALRSAVLRKDADTQAAVTVLLLRNYISTADITLADLLVRQTDFPSTASNSQVCRYLYYLGRIRAVQLNYSDAHETLESATRKSPTAGSAVGFYRQAMKLLVVVELLMGDIPQRAIFRQPNLEIALFPYFKLVQAVRVGDLQSFLKCVSVNEAQFKVDGTYTLILRLRQNVIKTGIRMLSLSYSRISLRDICTRLGVDSEESAEYITAKAIRDGVIEARLDHERGHLVTRSQRDTYGTTEPSEAFHARIQALLGMRDECVMAMRYPMNKHRQEIAEAAKAREREKELAKEIQEGEADAEDGDEGGFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C496</accession>
    <name>A0A6A7C496_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_284851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2862062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="10144" checksum="FD79269A74787CFA" modified="2020-06-17" version="1" fragment="single">RRPNIEREYDAGFERLYRDYFSDSPTFGHKASHRNLCMTRRIFLKITDALAAHNKPWTSFWPVGRNELDATVKLGIHPILKVTAATR</sequence>
</entry>
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    <accession>A0A6A7C4B9</accession>
    <name>A0A6A7C4B9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_275558</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01722">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="9885" checksum="2C3450431D32A428" modified="2020-06-17" version="1">MAITPDQLRSRIETELQPSHLEVVDLSGGCGQMYNVTIVSNAFEKKTALQRHRLVNSKLKDEIAAIHAWSTKCFTPEEWERKKTGDT</sequence>
</entry>
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    <name>A0A6A7C4D0_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="86"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C4E1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASCC2"/>
    </dbReference>
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        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="574"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="637" mass="70603" checksum="AD2CD3CAA5457969" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C615_9PEZI</name>
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            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
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</entry>
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    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="97"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="404"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="786"/>
            <end position="904"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="296"/>
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        </location>
    </feature>
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            <begin position="555"/>
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        </location>
    </feature>
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        <location>
            <begin position="623"/>
            <end position="659"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126271" checksum="5CF72331B2427969" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C733</accession>
    <name>A0A6A7C733_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_197596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="91"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
    <feature type="non-terminal residue" evidence="5">
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            <position position="389"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863250.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="42340" checksum="FB4E016CBD4413BB" modified="2020-06-17" version="1" fragment="single">HALSIPEGRSVSNLASPISISTSVGSAPWPPIRNTGPGSARSSRRSASATTSISPAHAFLTGLTRADPEPSPDDPKPDDEGQEIGPDDDRWVVGRTISRGGFGVVKEVQSISAAGVPIARAVKVVRKAIPDRSASENERAQQSLEHEVSVWRHLIHHHILRLRTVHETEYATYCFMDLVVGGTLHDVVIQSRQAVGGGLSPDTARLYSYQLASALRYLHQDVRVCHRDIKLENCLVDRSGSEVRLLLCDFGLADFIDNVPGDKSYQALKHAAAEMGKPTTSSVIGTLEYASPRGLSVRRKLFETAGDMWAFGIVVYTLCTGDLPFRGPFPAATVERIMRADWDETILRAAVEQGGGVADEVVELTKGCLELDMEKRLDIGHALQCAWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C764_9PEZI</name>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">K470DRAFT_255202</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025619026" description="gamma-glutamylcyclotransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="218" mass="26002" checksum="DB88D791F7071D0F" modified="2020-06-17" version="1">MMLTMLWLLSVLMASVILASSPSRGETNDQVAVPSHKGLYFGYGSNLWRTQMEQRCPTSEFLGIARLDGYRWIINKRGYANVVQFNLTDPHTGYPTNDTTDNDVVWGAVYYLNKQEEAKLDREEHVPWAYTKEYMPVKFWPKNTREPSIKDLPMLVYIDRKRVVPGKPRKEYLYRMNMAIRDALQERIPRKYVDKYLRKYIQEDWWRCDNPWRYPCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7K2</accession>
    <name>A0A6A7C7K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_241059</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7K2"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="307" mass="35453" checksum="3BE9F0657A8A0E16" modified="2020-06-17" version="1">MPSPTDPSWADITPLSAPAEPNGSLASISYTPNYAESISYLRALMAANEFSRRAIELTSEVISMNPAHYTVWLYREKCLERVGEDLLKEREWLDGIAEANEKNYQIWGHRIWLVTKIAGDPSTPIEDLCTTLTHERTLMQSMLNRDSKNYHVWGYRQWFVEHFSLFSSPSELTFVESMISEDVRNNSAWNFRWFLLSNRTPTENQWDQEMKYTREKINLAPQNQAAWNYLRAVAAKMGSSVKELKGCVERYVEAGDVVSLFALELMAEVKLQEGDKAGAGEALDLLAKRYDPLRRRYWEFRKASMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7K5</accession>
    <name>A0A6A7C7K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_103241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7K5"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="20499" checksum="28DF713564F6D52A" modified="2020-06-17" version="1">MDQVDELTRRFAQSIALQPVHQQYQLQQEAERQAVCTSNNVGLIYYASGHYTATAHIRSETVMFEELLQQNSINPSTVSSSQMQLFHQVDQPQRDLLIELWKVPPLSGTLNDGSPTSMEREKAEAVSRYEVHTRQYLQSIGLVREGESKPLEDGAPRADGNNGASLLGSHTGLSGIQAEDEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8G3</accession>
    <name>A0A6A7C8G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_103811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8G3"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="425"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="64281" checksum="9589C672A945903A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U8</accession>
    <name>A0A6A7C8U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_47470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U8"/>
    <dbReference type="OrthoDB" id="10664136at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="17991" checksum="B5F4C07B9AFCE389" modified="2020-06-17" version="1">MKIFLSKCLHSEEHPGQFSAVFPQILNGRAEAFYSGWENQRTNYKEVWPRRRVGLRTPLCYAHITAIASKPRAVKEVIKVDSGLAICSHWELVRLHNRTMENDVLALSQAQVSRRDSVKSRRVTNAATGLCSTMSKSACKKPTFQWPNMAPRSSFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8X2</accession>
    <name>A0A6A7C8X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_205735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8X2"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8919" checksum="792872A0E9ADB546" modified="2020-06-17" version="1" fragment="single">CACCSKTFRCSTNVVQHMQTHRPSRALPYACDFDSCERCFGRRTDLVRHEVSVHLKKKDHSCDLCGSRFARKDTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Y7</accession>
    <name>A0A6A7C8Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF689-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_254273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Y7"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BAR/IMD domain-like"/>
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    </dbReference>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="677"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="121277" checksum="DC352276340BD6E3" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9B8</accession>
    <name>A0A6A7C9B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_255344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
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        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
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        <property type="protein sequence ID" value="KAF2863228.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
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    </dbReference>
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        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
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        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
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        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="27360" checksum="30EFEBE8D1A369E3" modified="2020-06-17" version="1">MPGVNSATGLDFTNTSQIPLPPPKPFTPSLRQSSARKSIYDRNLQRPPAQSSLPAFAFLFNTIINYHHRHSASVAEIETRLNRAGYPIGVKMLDLIIYRLGNGNSSFSSAARGLTGSSSSSAGPGRPIRLLELLQFIHTHLFRTLFGRPADALEQSTTKKNEYMLIEHEPIVNTYISIPKEMSQLNCAAFVAGIIEGCCDAAGFSMEGVSAHWAGNGGGSGSGEEEMWPDKTIYLLRFSDEVIEREEARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9D3</accession>
    <name>A0A6A7C9D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_254493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
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    </dbReference>
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        <location>
            <begin position="408"/>
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        </location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="927" mass="102277" checksum="8861481B9F004412" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9H4</accession>
    <name>A0A6A7C9H4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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        <name evidence="2" type="ORF">K470DRAFT_50583</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025612152" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13342" checksum="AC457EBE8102C918" modified="2020-06-17" version="1">MKPTLILAFLAGAYALTDEEHCHKKNKYAPEVIRQLCNTDTMRVPNSRAFAGITNQGAMVTIDGTTCKSEWIPQKYCLSQFFNMCAHGDRNGQATASYGTHGCQKWQIQGIGKYSYVGGW</sequence>
</entry>
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    <accession>A0A6A7C9M0</accession>
    <name>A0A6A7C9M0_9PEZI</name>
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        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_240407</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
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    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4037694at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12796" checksum="5142CB18BB5A7934" modified="2020-06-17" version="1">MGFTTGLLGGFTLTAAVVYSTLTLHTHNRAYQAALIRQQTMLMQNIVDPQPPVPLSETRIVRAGLWETVKDGWNEEVERGVRRVQNVRWDEVYERLGAAAGRAWRRLFEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P6</accession>
    <name>A0A6A7C9P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_253955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9P6"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="338" mass="36628" checksum="8E6F69CC37DDE9AD" modified="2020-06-17" version="1">MPPKTSILIVGGGAVGSLAAYALSRSGQCHITLVCRSNYAAVSHDGLKISSITHGKNITYHPDEVVNTVPSAPSQNPYEYIVLTTKNTPDLTPTAAELISPAITPNHTTIILHQNGINIEKPFEEKYPHNSILSGISLIGASETSPGVIQHDEPDVSLIGPFTPTSTSISSAQKFVALYSHCPGVKCSFDENVPFTRWRKLLYNASYNSSAALLGLDVIRMRMSEFLISDLVKPVMGEVRAVAKASAGVELPAHLDEEMILSDSVEGNFMPSMGQDVRKGNPIEVENIVGEVVREARKCDVQVPVLGTVYTLLRGVQLRILEQKGLWGPGWREGNPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9V6</accession>
    <name>A0A6A7C9V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_209030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9V6"/>
    <dbReference type="OrthoDB" id="3780108at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="57" mass="6518" checksum="6D2B85524A24C9BA" modified="2020-06-17" version="1" fragment="single">SARFMKSVTSKNTWEAMRLVWMDVYQGPPDVIEHHVGINFSSNSEVKPISWKPNSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9X6</accession>
    <name>A0A6A7C9X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9X6"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="472" mass="50332" checksum="4398CA9819D8A1A7" modified="2020-06-17" version="1">MAGGSGRVCEYFLQGKCKFGGNCKNEHPRNNTRTFGGGGSGSGGRVRKLSPIGLPYYLNEDVIRSDLTVDRPEWKLSAYGPGRDAPRQLIGGAVEISPEEMRAQERLANSYGRSDEYKQMERNAFDQADREVRGVLNKIPEAIDYVIAGANNHPNRLDGVLKNSKTFAQHGASGMPQNLPPAQSSAFGRTNNSFGKPSPLGNQPAFGIPSPAAASSPSQNPFTAQLQAQRANSPQAPAANQSPNHNPFGAGAQVGTRTGPNPFAVNTVAASLFTQPKPQLAVATAQARNIPMAQPSPMNLTTPSPSTAVFPNKPSFNKPAFLSPAGGINLSAPATPTLSGAPAAPGRLTPALAPNLAATASYTTRDANGKLLTWKGHRVEWESDSVPGAIIVPRIEKAYIQNPQTGKQERIWHPNGPPTTGHKYAEAAPETYDGPIGSLLKSAYEYARETGWFKDGVMPEIPPKREWVAWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA62</accession>
    <name>A0A6A7CA62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_267161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA62"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="655" mass="72712" checksum="E40B62583A4ABF7D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAN1</accession>
    <name>A0A6A7CAN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAN1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="643" mass="72012" checksum="1D4988615986AE0E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAN3</accession>
    <name>A0A6A7CAN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_226304</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAN3"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="IRE1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5025567948" description="non-specific serine/threonine protein kinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1097"/>
        </location>
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        <location>
            <begin position="654"/>
            <end position="952"/>
        </location>
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        <location>
            <begin position="955"/>
            <end position="1096"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="453"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="509"/>
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        </location>
    </feature>
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        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122675" checksum="E68C91EB87EBAF4A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAQ3</accession>
    <name>A0A6A7CAQ3_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_224800</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="367" mass="39461" checksum="31B4EB0687A35EE9" modified="2020-06-17" version="1">MPFDTALTRKLGIHVPVVQGGMQWVGYAELAAAVSNAGGLGIITALTQPTPEDLRREIRRCKQMTDKPFGVNLTLLPAMVPPNYDAYAGVLLEEGIRIVETAGNNPGPMIKLLKGATPPCVIIHKCTSIRHAQSAVGMGVDFLSIDGFECAGHVGETDITNFILLSKARQVLKVPFIASGGFADGQGLAAALSLGAEGINMGTRFMCTVEAPIHENIKKAIVDAQETDTELVLRRWRNTNRLFKNKASMGAIKVERESTTGKFEEVAPYVSGKRGRQVFLNGDKDYGVWTAGQVIGLIHDIPTCADLLTRMEREAAETLKQRLNLFVESPPRPGQIAGKPAGDTSSKPSGNKVPGEAQIYDIGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAT3</accession>
    <name>A0A6A7CAT3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">RalA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
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    </dbReference>
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        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="142" mass="16087" checksum="633A97B44419BD6F" modified="2020-06-17" version="1">MSWVQKHINLPARGRGTFLITSDIVKSIPEVKNYDVGLLNLFIQHTSCALTLNENWDSDVREDMSDALDRLAPEDERLYRHSAEGKDDMPAHIKAALIGASVTVPIRDGKLDTGTWQGIWFLEFRDAKQERRVVATLQGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPM1</accession>
    <name>A0A6A7BPM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="21"/>
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        </location>
    </feature>
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        <location>
            <begin position="45"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="87"/>
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        </location>
    </feature>
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        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="19056" checksum="8DF2576F41B79AB3" modified="2020-06-17" version="1">MGGDTYGSGRGTGAGTGSGLTGSDTYGSSGRDTYGSSGSDTYGSSGTGSGTTGGTTYGSSGSGDTYGSSGRDNYGSSGSGRDTYGSSGSGLGSGTTGSGRDTYGSSGSGLGSGDTYGSSGSDSYGTGNTGSSGGRHGASDYGSGATGGGIGSSGHKGGDSTMGKVQEKVGDMLGNRDMTEKGREKREAAGLNQGSSGYGGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="56" mass="6301" checksum="0EE81C775092786C" modified="2020-06-17" version="1">MTNPLLTQHTHENLCLVFSAPFHSAPPPAMSQRLSTLPRLTPPNQLPQRSILRQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BQA1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_266864</name>
    </gene>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="1">
        <location>
            <begin position="180"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="626" mass="70685" checksum="ED7B374016B378C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQM4</accession>
    <name>A0A6A7BQM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_169733</name>
    </gene>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
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            <end position="119"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="229" mass="26420" checksum="FB2D3B48D6712021" modified="2020-06-17" version="1">MNTINTKAICDVGASANLEQENKEKRAQIFKRAESYVKEYRDAEREKIRLARVAKAEGSYYVPDEPKLVFVVRIKGINKIDPKKRKTLKLLRLLQINNGVFVRMNKAMSEMLKIVEPFVAYGYPNLKSVRELIYKRGYAKTAEHQRIPLTDNAIIEEHLGKLGIVCMEDLIHEIFTVGPNFKQASNFLWPFKLSNPTGGFRPRKFKHFVEGGDLGNREEHINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQT5</accession>
    <name>A0A6A7BQT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_260647</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQT5"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="17820" checksum="A69D1A1642ED7680" modified="2020-06-17" version="1">MASTLDHEKLVRLQNAQRTGGKGTPRRPTKKVHKSAGTDDKKLQTTLKKLNVQPINAIEEVNMFKSDGNVIHFAAPKVHAAVQSNTFAIYGKGEEKELTELVPGILNQLGPDSLASLRKLAESYQTLQKAEEPQKKEADDDDDEIPSLVEGKDFENKDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQU7</accession>
    <name>A0A6A7BQU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_13511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQU7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="188" mass="21685" checksum="E252EC2C02257287" modified="2020-06-17" version="1">MSSQIHYSLAFIRTDVFHYLQHRDLPHCSNETIWIALVAVTEEVPRSRCNLHNRVEVCCSLVSSQYNSMFCHSTQYGCSICSQWRQVSKWIFDTLTCETKVAGQISIKARKSEPTKDLLQSSICCAPIKLFISSRLEEATQRANSSKSDLNRRVIQGLVPEASDKPQWHTMQYFKWDILVRIKSLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR02</accession>
    <name>A0A6A7BR02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_223573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR02"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="207"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="337" mass="36404" checksum="5C611CB45218B4FA" modified="2020-06-17" version="1">MAVTFTCLWQPVACQRLPLLFRSAARRGFCSGNGLRTDYGFIGLGQMGFPMAVNLGRHTPDADKLHVYDVNEKALDSISTKVGEKLRVEESVHEVAKKSDVIITALPEPSHVKSVFEQMLHPRLPSKQRLFIDCSTIDPMTSQEVANEVDSTGSGRFVDAPMSGGVVGATNKTLTFMIGSAPELVEQATAVLSMMGKRVVHLGPPTSGLKAKLANNYLLALNNIATAEALNLGVRWGLDAKKLSEMINTATGKCWPSDVNNPVPSVDPRAPASQDYRGGFGTKLMLKDLTLALKAAEEANVAPLLGGHAKDIYTAVEATDGCQNRDFSVVYKYLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR11</accession>
    <name>A0A6A7BR11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_296925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR11"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="601" mass="66541" checksum="0C0701ED997DEE6D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY6</accession>
    <name>A0A6A7BRY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY6"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="613"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="755" mass="84137" checksum="C689961EABC5609F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS15</accession>
    <name>A0A6A7BS15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_171347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS15"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="80" mass="9080" checksum="BE401C54D4A9DD91" modified="2020-06-17" version="1">MAVKRWGCVCHVEVSLLPLGMSLISLRIWSMSNYWAFLISGNRLRYGVRAEPHTPDPRPQTPKPGTCNKVFMVLRTFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSG4</accession>
    <name>A0A6A7BSG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_191400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSG4"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="18887" checksum="600CAB0757646C66" modified="2020-06-17" version="1" fragment="single">LQNISQLLRHINHRNKNQHRRSVWWRHFSTFRKELERLRKEAAFLLESPTTHVERQRKKARSADLARQIDQRIVFWQDIQVPKWERAFSQIVADIRFSSIGLVLLASLAESCRTCGITAKLNHAESKKVMDQFSQKTRTTTSAEDEDLGEAVARETYDSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK2</accession>
    <name>A0A6A7BSK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSK2"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="257" mass="28288" checksum="3D0AA54FB85CC197" modified="2020-06-17" version="1">MDAFYAAPPVSRTLTAAAVLVSAPAWAGLVSLYRYVWITRRVFTLSHFPQVWRLATAFLITGPKLSIVLDPYFLYTYSSQLEQSKFADPADFVVYLAFVCSIIVLLSGVYLGGVMLLGPLNLALAYTWAQENPNRQITYFVVSFSAKFLPLVMLAMAFVMGSPEDALNQLPGLIAAHGYEFLTKVWPEHGGGRQYITTPTFVKNWFGGTAPRQRGFGTAIPAAQPGRQQQQQQPGRGWTSGLAGSWSQRGPGRRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT11</accession>
    <name>A0A6A7BT11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_221746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT11"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
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    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="353" mass="40782" checksum="E31392442B0D65D0" modified="2020-06-17" version="1">MGCGQSSESKEGKQRNEEIENQLKRDKMNQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFREIIFSNTVQSMRVILEAMESLEIPLEDQQAEYHVQMIFMQPAQIEGDVLPAEVGQAIKTLWADAGVQAAFQRSREYQLNDSAKYYFDSIDTIASPTYIPSDQDVLRSRVKTTGITETTFFIGELIYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFTKTSIILFLNKIDRFKEKLPLSPMKNFFPEYDGGDDYNAACDYILNRFVSLNQHPTKQIYTHFTCATDTMQIRFVMAAVNDIIIQENLRMCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT91</accession>
    <name>A0A6A7BT91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_221559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT91"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="31270" checksum="C3DD2852CDBB9BB3" modified="2020-06-17" version="1">MADPFDAALDLLRRLPPSRTSETLTKIISLRPELEEDLLSSVDVSLTSQRCTKTGRDYLCCDYNRDGTSYRSPWSNEFEPPLPDADDDDLKPSGRIRRMEESLNSAIDVYRELYYDGGISSAYLWALDQAQSGFAGVILLQNRTPKGGEWDGIHVFEVEEAATKRSALYKLTSTVILDLQGQQKLTAGPAVELAGNLTRQTQADMQLTGFREAEIEKSHVANMGRMVEDMETRMRNMLQDVYFGKARDVVGDLRSLVPLNEVASERAAHRDVIEKMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTD9</accession>
    <name>A0A6A7BTD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_221308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IM_YidH-like"/>
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        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="64"/>
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        </location>
    </feature>
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            <begin position="166"/>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858403.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="21163" checksum="6D65007E609778FF" modified="2020-06-17" version="1">MESNAQHQSESSASSVHGNSPEPSDQDSIDQKSWWKRILDKYGSIELENKGSVARDHLALERTFLAWLRTSLSFASIGIAVTQLFRLNSSLNSDSSSSPPSYSSEAKLDLRSPASREAHPLKQAGKPLGATFLAISILILLIGFHRYFESQHYVIRGKFPASRGSIVLVSLVAFGLIVSSLVVIIAIAPSVLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BTI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_251005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
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        </location>
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        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858571.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="631" mass="71132" checksum="41927064AFCE2DC7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_207402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="14431" checksum="A3446540D2F83449" modified="2020-06-17" version="1" fragment="single">DDGRHRNHPLYGKGPHPDGLYHCPFAEEAHCEQQHPPIKLKCQYDKYIDSHIKPFRCRAETCANAVFSSTACLLRHEREAHAMHGYGANPHLCFYPGCERQIRGFPRRYNLFDHMKRVHQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTM5</accession>
    <name>A0A6A7BTM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_128296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3142434at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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</entry>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42583" checksum="470DB61516006523" modified="2020-06-17" version="1">MSDFSFLGSFEPNAILRGAQLTLVGANRALQNPAIFTNTHYRQAAYAVAAGIVIRLILLIPTWSVRALIVIAGLFTDLSQVTWDEKLVNGTRFLEHSVLQLPFFLMSLIRYMSPAMDQMFMDSLAWVDRTYVQKHHSEDPAALRAMYYPNLRLYDTRGSEVERKPRHSTSDAVTAFLKRFGKRTATSLVVYLASFLPYIGPLVLPAASFYTFNKAVGWQPAVIIFGSSVFVPKRYLVRFLQSYFSSRGLMRELLEPYFSRLHFSPQQKKMWFKEREGVLYGFALAFFIILKIPLLGVLIYGIAEASTAYLITKITSPPPPPAEAELFKQRDIKWVNKHEFLSLPLDKLDKLNIKASGRLLHPEMVGSPVPTKQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUE5</accession>
    <name>A0A6A7BUE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_300651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUE5"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="584" mass="65019" checksum="DC0EE55122C8F545" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUG7</accession>
    <name>A0A6A7BUG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_289540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUG7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="377" mass="43013" checksum="57173C7B936F4E48" modified="2020-06-17" version="1">MKFPDGPLDMTDTFPTEILLDVFGRLACHPDALYNAIRVCKDWEDAGTAITWHTVNSELLDGIPLERRQHYAVKIFDLSCPADKQMLVRTGGLSFPRLNSLQITLQQINNERAQPSEIRGVQPIQAMENLLDLMPARMPRLRHVVLHGQPDDWKMVQEFFMKIDNLQSVEISNPVGMSTTIADSLVGHFSQRPSFFSLKGPIPVTENAVQRASQSYATYFSQLRELEMVASAATVSIFSKIAQDLRSLRVNLEGPLEEVFKSVSALHNLEHLVLCIQTSLSNGIPTFTKDDFKHLQTMHKLRHLEVVVRNRRVPLPRAHSLKDEDFGLLFYNLRSLKYFYMECDNRLTSKTLDYINELCPHLTACWYGPDSVKGWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUR0</accession>
    <name>A0A6A7BUR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUR0"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="336" mass="36942" checksum="5CDD0BFCFC7E803A" modified="2020-06-17" version="1" fragment="single">MTHLDLFLQRGPPNGDLAAGLEELRRAVLLDGIPSNSDGMSELRMYIWLVLLNVPPMPTDTYLDLTRQGASPAYTKIRNDTFRTLTTDPLFRRRVTENSLTRVLNAIAWKLHDAHEARVNGWTNLPTLGPPSGPDLGFNSPASMTPRGRFGSVAGTECSDSADTSGYVGYVQGMNVLAAPFLYAARSEAEAFAAFDRCITHECPGYVRGSMEGVHKGLALVDQILGIVDPKLSQHLLSKGMKAEIYAFPSVLTMCACTPPLPEVLLLWDFLFAFGPHLNILCIVAQLVLLRDSLLASPSPKPEFKPLRARKVIDLTVNFARKIPDHVYQSMLTHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUX5</accession>
    <name>A0A6A7BUX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_296328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUX5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="170" mass="19759" checksum="28755C6596B0FB5A" modified="2020-06-17" version="1">MTGHPLWLIRSQNIEPKRQFKREVKEELEETIKEIREELRRALGKEVKQDPSQEIEQQSRDGNSVPIDSVKPAKLKAPKDQQASDQTSTENLDTPRPARPNELDPLDDDMRKDRDDSKVGIKQGHDPWAPEQRGTKQHERDNSLKHESKSASRPQGSERELKRRKEHDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVD5</accession>
    <name>A0A6A7BVD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_265549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVD5"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="121" mass="13214" checksum="3F13BA5C747EBC69" modified="2020-06-17" version="1">MHRQRMTTWDWTIKALRPGTQIDGRLVEASQGHLYIGIQAVTYCPASAGHCLNNNTIYARSILGTVSQSQLIYVQTDGAVVYTEAGGNYTNMLIGGFGGDYYAIDAPPYVVDQEYKGGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVH7</accession>
    <name>A0A6A7BVH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_112168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVH7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="26731" checksum="218844BD221AD17E" modified="2020-06-17" version="1">MLPPTIVIIHDAFAHPAPYTNFIAQLHAEGLTEVRVPHLPSTEGGDPERDVPVVKRTIESCLTSGRDVLVLAHGYGGSLIGDAVTGVNVTAGKSNNAKLMGIVFVAGVIASPGESYLDAFEGGMPSWIQKDGTMCTINDPGAVFFNTLKDAEIHEDLVKHTQPQALSALERRVTSTNWDRVPCAYIICRQDHSMSVEEQQRMVKKLQRFRPTTVTTTLDYDHCPMHCVSARMASIVKAMVGQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVM6</accession>
    <name>A0A6A7BVM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_259716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVM6"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVZ7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025459557" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="107" mass="11768" checksum="64B8475AB47A8E98" modified="2020-06-17" version="1">MSEATSLLTLTLIYVILHDMTLETEDFRLTISRSAVAIRGGSFKALAASTRDTAGMIPMKKHMAKDVGFAAFHASTLRTIWAMSVYQCLRISKTTEKHSSGDIRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWC3</accession>
    <name>A0A6A7BWC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase, alpha subcomplex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_218723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10581" checksum="4F14A3168E9D5F63" modified="2020-06-17" version="1">MSGKYAFSSALKELRFLHCQTSEHSNAVRSFLTRSYPQMKKQNPHTPIMIREANGTEPRVYARFEYGREKMVDLKGLNDGAIEDKVSSLVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWE0</accession>
    <name>A0A6A7BWE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_218652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWE0"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="656"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124795" checksum="88A1ED40E43DDE87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWZ6</accession>
    <name>A0A6A7BWZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_93701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="22955" checksum="E43A7B837A8A99E2" modified="2020-06-17" version="1">MVHFAYHQDYAPGLLQHQPAPLELSRICSRCQYTMRLRIDPMYLSQGFEYVQNNDEGDCGNVILNMVMHAKVFAVAIKYQFPSLETIAIEKFRDTIIWNWNHDTFAEAISSVYHRTSDQETGLREIVAETLANENGILDEPDIEAVVKEIPDLAYQVLRKVRKKTNLRNPLYRSSNKWNMQRPGLPPLYANASFAYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX84</accession>
    <name>A0A6A7BX84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_258321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 480.64</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
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    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="124"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="457"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
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        <location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2859976.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="106931" checksum="82860AE189BF5854" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXD0</accession>
    <name>A0A6A7BXD0_9PEZI</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 480.64</strain>
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        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
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        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXD0"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="26">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF2859369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="659" mass="72990" checksum="3110E7019EC96D00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXG4</accession>
    <name>A0A6A7BXG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_217813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXG4"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="679" mass="76781" checksum="1A004E1C03EFCBE0" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXM8</accession>
    <name>A0A6A7BXM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_218070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXM8"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="531" mass="60823" checksum="DE618BB456F3EEBE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYH9</accession>
    <name>A0A6A7BYH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">K470DRAFT_258375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYH9"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="369" mass="41126" checksum="137666A2CA361E09" modified="2020-06-17" version="1">MLEFMDTVLAAFHVQTRWDVDQSYATLTATAHNVLDFHIPNGVKIHASSLSSPNFATSYTLGSRGVVDGSLSFLYSSLGLHLDSQSARVPLESVVKGYRQLRRRQPLEEGNSPRSDHKKDSLLYGRVYLPGNSLEALYLRRISARRLLRLNCVSDGQIPNSSTLLAVLQNDNGRYSTEYLYSTDSSLLGVRGLYNFGYNERSGRLSAGAEAYFSPVNKSGGMSCGLRFTTLPAHGAFPYTMTLTVNPLMGNLSSAYAVKAGPDLAFCSRFDFNVYSYESQVTVGMELWKRGWASPETAWMRQMIRPGWKRNEEDITGVFKARMDTHGKFGLLWETKYKDLLVSMGTGLDLKSEERMVMGNVGLEVSYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX2</accession>
    <name>A0A6A7BYX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE/PHD zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_196952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
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        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="17040" checksum="4C0E3DC5ADF80825" modified="2020-06-17" version="1" fragment="single">ELDREALRQRLRAAEAACVYADPSDITGPPTTAHWKPDAASVQCAVCNRPFTWSFRRHHCRHCGHVVCDADSSKLVPLDQHARLHMYGTPSRACDPCYTEWTRVKQRILDGAADASARETPWDIPRRQRPEQLDQVGSPARSEEMVWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZS9</accession>
    <name>A0A6A7BZS9_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_202646</name>
    </gene>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860826.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="278" mass="30599" checksum="E04FD7348E4336BB" modified="2020-06-17" version="1" fragment="single">MLVSLTVGKVDAGVAVLLTEDKRLIEFPALLLPPEIQSGSIVEINVSRNRPAEHLAEQKFNTLQTEILDAFGSASPSPPQLRCRNTTQTSVVLEWDPIDTASAELRSLTLYRNGSKAGAIPAGKTTTKISGLAMDTEYTFYLVLKTSAGRYSSERVTVHTHKLTDLHGITVTPGVMPEQLKESLRATLERIGGKMIDSLRIDTTHFVCTEPRGPGWEKAVEMNVPIVVPDWVKGCEREGRMVPARAYYLDADPSKRMLGPVKDMPTIEHTPPTPERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZY5</accession>
    <name>A0A6A7BZY5_9PEZI</name>
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        <name evidence="6" type="ORF">K470DRAFT_281811</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="linoleate_diol_synthase_like"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114191" checksum="7488511DED67EA06" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C075</accession>
    <name>A0A6A7C075_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_215996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C075"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="19288" checksum="2DF2B85B448C1E41" modified="2020-06-17" version="1">MKAPNSAPSHQEATKDAPTLEDVPIPQKQDANLRDFLAKMNDYAPLIPDAVVDHYLTMAGLPPPPATDRSLARLLALTTQKFIADIAADAYQYSRIRSTNTTSNNPLSGLGGAAGFGMNLPAGGGEEGGKGRKEASKNVPLGGPRAGYGGAPTGGQGRTVLTMEDLGMAVGEYGVNVKRSEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0R2</accession>
    <name>A0A6A7C0R2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0R2"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="360" mass="39267" checksum="504156D58350D486" modified="2020-06-17" version="1">MDIAYDRVQEGTLSPTTERPTNSNVAETLEGSSAKGNSNTSGQAGSTLQTDLSSAFMSFSSTPWGNRLGGMLQHGAQWVEELQREANAAVEEGLETLRKRTGSFATASPGPQSMVPGEEGVPTTRAAVTVSNSTEASSSTQLSDSKSSQPATSSDKPESLPADILKEAGSMVNSLRTSAAARLRQLQAGEQTPEDIASRLGTNLRNLLKEAIAVSPPREGEGKKELLFETSEASGKKVFHATRLDAALHEIHTNDESFLFDLKPTEESGEDVKTPGGKEADISALTERISSDLEKYPDLRAAMERLVPEQISYETFWKRYYSIREVIEDKERKRREVLKGMQFLASHKLYAHPFLYSTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0X7</accession>
    <name>A0A6A7C0X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_60797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7C0X7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="HSF"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="82"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="225"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
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        </location>
    </feature>
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            <end position="214"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="499"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="529" mass="59574" checksum="9008B1F70EF5BDFD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C197</accession>
    <name>A0A6A7C197_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="488" mass="53188" checksum="DF042098E6E0E5B0" modified="2020-06-17" version="1">MSQDLLAAFGEAPPSDRLPKATIDDDNFDDFGDFEDASTVAAHAESSRAPAWKNENPFESKPSFSTQKVVAPGSSKKEESVAPNPLPIRKATPQKTGEDSKIGRHPFAGNMALLFDDNDGDYNAGVDEIDNLAMNPEAAMAYSKKVIREQMEKQDGLPTASDSNILFDVDDYTKEDKGGNDLLSWENDVPTSATAVEVEDDGGWDDFEAAPAAMGANNQAETEDWWDEFQPAASKDIQAAHEEAGGENRSSPSPTAKGSTVDPDPSELPPTNIPPPSLLLSLFPPSFTEVNTILLSPLSKLPISSTDRIAFLSDPATHQYLSSHLQTARVLGHIIAGRKARWKRDIFLSQGMRIGASSGKGGMKLAGIDRAELRKEDREVLDVLALWGAQVGKVRAAVAGANSNARSKGQTIQPPPELSVNMKVTCLAPAEGGFRASRQCALCGLRREERVDKLDVNIEDSFGEWWLDAVLMHTECWAWWRDNRDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1K4</accession>
    <name>A0A6A7C1K4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Osmotin, thaumatin-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_299293</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="40695" checksum="C6D669F8FCC3E54E" modified="2020-06-17" version="1" fragment="single">MPASTSTKPSTWRPSTLTKPTASPATVEVKPSMLSNTESTRTLLPKLLTTLLALATCLGLASAEHHMKRQPTLEARQSVNTVPLTINNQCPSTVWVGVYTTGNDVDLNTGFALDAQQTRAFNVPTHWQGRVWGRTNCTFGSMNSVGGYGEACVTGDCGGVLDCKTPGNPPATLAEFTMNGSDSQTFYDISLVDGYNLPMAIIMDPNGVPALEKINLASTNPSCVASIGDFGPMDWNPYASGQSFLGTTLTNPLPFVKTLTAALVAAWCPWDLQSSMPEGPANGVFRYPDMSVLRPAFDPCVSACYKHRTDEYCCTGEHNLPSTCSASYYSKAAKTVCPDAYSFAFDDTTSTFITPAGGGYEVRFCPGGFSTDILKDTKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L1</accession>
    <name>A0A6A7C1L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_215756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF447">
        <property type="entry name" value="FK506-BINDING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="125" mass="13227" checksum="97F68A7752061065" modified="2020-06-17" version="1">MSPSKITKKQILPGNGVDRPKAGDTILMEYTGNLYDPNAPDGKGKQFDTSVGRGDFETQIGVGRVIKGWDEGVLTLDGGMTLGEKATLTIPGEFAYGSRGFPGLIPANATLIFDVQLKGINGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1P4</accession>
    <name>A0A6A7C1P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_299703</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1P4"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2860608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="399" mass="44544" checksum="19C96C8694F199A9" modified="2020-06-17" version="1">MDDAVVKATDENLTSENWALILDVCDRVSASSAGPSKAISALIKRLAHRNANVQIYSLGLAYALSQNCGQPLHRELASKAFTDALLRLASDRTTHPQVKQKVMERMQEWTDEFRSNPDLGIMESAYGRLRTQQSGLMPPSKPGKREISSEDRRREEEELQMALELSVQEHKGVKATQQGSGQTEKDDGGAYESVQHATAGAQSARGTAATVSRVRALYDFVPSEPGELAFKKNDVIAVLESVYKDWWKGSLRGETGIFPLNYVEKLPDLSKEDAEKDAQLEAEVFGEIANVEKLLALLSVGGGRRSERDEEEIADLYHQTVSIRPKLIELIGKYSQKKDDYTQLNEKFIKARRDYEALLEASMAAPQHYHSAASPHGYGQMPYDYQNQQWPGRPIQHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1R8</accession>
    <name>A0A6A7C1R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_257077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1R8"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="99"/>
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        </location>
    </feature>
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        <location>
            <begin position="150"/>
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        </location>
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            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="184"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="532" mass="59742" checksum="A952492B2885DAA1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2E3</accession>
    <name>A0A6A7C2E3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
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    </reference>
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        <text evidence="1">Protein modification; protein glycosylation.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OGT/SEC/SPY_C"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="894"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1387" mass="154094" checksum="8EDFF24CB86DEFB1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2N0</accession>
    <name>A0A6A7C2N0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_207978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2N0"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="23304" checksum="0E8E7C7E034E0492" modified="2020-06-17" version="1" fragment="single">LECCSGGDLHRCIKHWHRLQREQGWLVPTIFTKHFVADMATALGYIHLGIKDIHKPDRTETNHHQILHRDKGSQNVFPRWTSQNHNGMPDIVLGDFGLACLGAASRGACGTPGYNPTECQAVYNLPSVQAVRRQVQALRLDMYCFGATLWSICTTAQFNNSTEQCDADRINRHVGSWPVARDPVLISLLTRCFDDEPSVRPNSRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2T4</accession>
    <name>A0A6A7C2T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_269418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2T4"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="668" mass="74677" checksum="488FD6475181B649" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2V9</accession>
    <name>A0A6A7C2V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_214573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2V9"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="90" mass="10446" checksum="47705FA9B9BE683F" modified="2020-06-17" version="1">MRPTTILRSGGPKVPYPKHVWSPAGGWYAQPKNWKQNTMIVGAAMTGICVMLWGVSADREQRDRMPDPDRFYPSRYWSRQIIEHERGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W4</accession>
    <name>A0A6A7C2W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_281182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W4"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="47187" checksum="721FB28D93A729BA" modified="2020-06-17" version="1">MTHLLILLHGLWGNPSHLHSLRTAIETEHPTLEVFIPSTTSHYHTYDGIEVCAERVAHEIETHITSNPSVTYAKLSIVGYSLGGLIGRYVIGLLYANGLFTTLQPINFTTFASPHLGVRSLGDKGLGIWNYLGSRVLSTSGTQLFLSDTFRETNKPLLEVLSDPTRIFIKSLRQFKKITLYANTNNDRSVPYYTAAVTDKDPFLDLDAVEVHPLWEKVVLDPLNPASPITPSPVTWQERYIMSNRTRANLPFYAVLAGVLPIAVPIFLANAGYQTYKSAQRVREHERGDVGRFRERILEEVREGMDNVEAETREMVQGEGGFLPTPPPERRGKQQSNPPNEQQTKPEEQPEDWPPTLSLSKTQKTIMTNLRKNVNFTAYPVHITKVRHTHAAIVVRREDENFTEGWEVIGHWVGGFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C317</accession>
    <name>A0A6A7C317_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">K470DRAFT_46571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C317"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="362" mass="39821" checksum="DFD21EA81B930501" modified="2020-06-17" version="1">MTLEAISYQPGSLQILDQLLLHHKSNYISIRTAEDAHNAISKMQVRGAPAIAIVAVLSLAVELHNNKDNFPQSAQAMADFVNQKLNYLLTSRPTAVNLSNAVRELAAQPYPNATSEDVVKEYTNRAEEIFRADLSTNKSLSSHGTEWLCKASLSPRRLNILTHCNTGSLATSGWGTALGVVRSLHSRGALERVYFTETRPYNQGARLTAYEVLSDQLPGMLIPDSAVASLLRSRQIDAVIVGADRIARNGDTANKIGTYGIAIAARYHGVKFLVAAPLSTVDWELEGGEQIKIEERAAEEFVKLGDVRLAPEGTEAWNPAFDVTPAALIDGIVTEEGIVERDGDRFNLKAFRRRVERERKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C395</accession>
    <name>A0A6A7C395_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_215490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C395"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="116" mass="13462" checksum="8A051D16740D95D9" modified="2020-06-17" version="1">MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKLEKSEIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDGVLPPTAAQMNSVYEEHKSDDGFLYITYSGENTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3A7</accession>
    <name>A0A6A7C3A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3A7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="125" mass="14324" checksum="D9AE29E46E10D23C" modified="2020-06-17" version="1">MRSPSRHCGRPFVSRWSTPTRRTTTASSGKLKGWRSCCRWRTAPSKTPADIPGAGKRRNRLLPAIIVDVSICKGIAMLRQIPKAKNYKPDYGIGWRWSSGTTHHGADRRYNSQRSDRYRRCSKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3C3</accession>
    <name>A0A6A7C3C3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_256497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3C3"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12538" checksum="CC859620382925A9" modified="2020-06-17" version="1">MRLLTGGQFPCGRVKRFLKSQTQNKMRVGVKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKRKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3C5</accession>
    <name>A0A6A7C3C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3C5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="209" mass="23291" checksum="37E5FC5D0140C7DC" modified="2020-06-17" version="1">MPLCGSGKTVQRKLVLLGDGACGKTSLLNVFTRGFFPTVYEPTVFENYVHDIFIDNVHVELSLWDTAGQEEYDRLRSLSYDDTHAIMLCFSVDNPDSLENVEAKWVGEIADNCPNVKLLLVALKCDLREQRADEEDSVVATQSSTEPKRPMVDYQQGLAVAEKIKALRYLECSAKKNRGVNEAFTEAARIALSVKIPGVKDRKGRCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C430</accession>
    <name>A0A6A7C430_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_285270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C430"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="18820" checksum="852C8C8F76F60A0B" modified="2020-06-17" version="1">MPSRPSPTSAGGGNWRASSTYVPIDDVPGRYFGFNTYNEARAVCKSLRPVNNTKPSNHGINKVGGARPKVALPKKKNRMIIKGVCCSSCTLLVPARKTAKKPTKAMSPLVSAPQQPSEKMVANKKAIREEASRLLPPVLIDVCALAGSWCDTIALQIELEPKAHRWILGVGMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A9</accession>
    <name>A0A6A7C4A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_213523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A9"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="264" mass="29728" checksum="CE07D0B5661F7BE0" modified="2020-06-17" version="1">MAAVNLPDARRLKSYLFRIPLATRLIILLITVFYIATVFVPWLRQWGALVPHEISLSTLYRLNTFPLLHRDFVHFLSNILVLVPLLDRFEQEHGTMVTLALFTGQFGLLPGGLYTLLERHVFRLDSSAIGASVWVFLLLSYEAVRTSKTHPHLVIMNYKIPTWITPLAPLLLISFLIPHSSFLGHSCGAVVGYVWGLGYIRFLAPPDKVLRWLEARLNLLGRLPRYVSVDQKTYGRYGVLPTSSNGRPGTANGSKPGQRLGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4J9</accession>
    <name>A0A6A7C4J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_280943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4J9"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025341690" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35030" checksum="E586078B098B1794" modified="2020-06-17" version="1">MRPTTLPLLASVASLTAAVTPPPYVLTYAPIHYLHPDEKFLPSDISTHLLNVIPYKNNTPIPSPNPLTPTNLNTLSGDVYLTSRSDPTLFTSPQNAWEHGSLTAHQSSVIITTHPQSNPTTIDAYYFTFYSLDYGGIYLGHNIGNHVGDWEHVMIRFVNATPTQVWLSQHANGEAFYYNTLEKEGVRPVVYIANGTHANYAVTGTHDHAIPDLNLPAGVVVDHTGKGARFDPTVGGYYAEFDAATGGFSGETVGFLGFRGRWGDRKYEEGFRGQDCPLGITQLCKWTDGPTGPWDKDLKRDTVCPDNGILCIVRWVLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Q5</accession>
    <name>A0A6A7C4Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Q5"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="464" mass="50353" checksum="32E0E8F8E1121DE3" modified="2020-06-17" version="1">MDRLRKLFAQDEVGYEPINTGTGPTEHESLPSTPSSSTKEVGSFRSAKVGYAIYLLMGVSMLWAWNMFLAAGPYFRKRFRTSDWILVHFQAVETSVSTIINLVAVIALTFFQSTETGGTKSETFKFSYVQRIFASLVLNALVFLFLSFATLPVFALGAESYFSFLICMVLLASLATGLCQNGLFAYVSGYSNGVREVYTQAIMAGQAVAGVLPAIVEICTAASRRNTKGSGKVLAYFATAVGVEVAAFFGFAYLLLSTHKAHDEDADANTPTMDGEVENEESAEVTSHVPIFVLWRKLSLPATAIFLTFGITMVFPVFTERIHSNNAAQEWFFAPPEIFIPLAYLFWNTGDLLGRLFAPFCADRFIPHPGSLLLLAASRIVFVGLYLLCNIRGHGAVVKSDFFYLVVVQALFGASNGFLGALCMMGVGTWVGREERSAAGAFMSLAMVVGLASGSLTSFAFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T5</accession>
    <name>A0A6A7C4T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_213533</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="45"/>
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        </location>
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        </location>
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        </location>
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            <begin position="1157"/>
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        </source>
    </evidence>
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    <sequence length="1657" mass="186536" checksum="3500B6F4E1D49AC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="77"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_227327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C645"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="132"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="58909" checksum="871AD4296B19D63C" modified="2020-06-17" version="1">MESDDDMASVTSSGLDDTSSVGFGADESDEDFVEYQSDDSDAYEAEKPKKSAFEVDYTVYSPSAIQEQQDKQVSEVAMLMNQPREAAAILLRYARWNKEWLVDKYVDNEENLLKSAGLGEASKTPPRIEKKPGFECEICCEDGSGLDTFALSCGHRFCVNCYRHYLDQKISEEGEAARIRCPGEGCNQILDARSLHLLLSQKLLARYNELLTRSYVDDREPLKWCPAPECVYAIECSVKPSDLKYIVPTVTCDCHYAFCFGCTLADHQPSPCTIVKRWLKKCADDSETSNWISANTKECPRCQSTIEKNGGCNHMTCRKCRHEFCWTCMGLWSEHGTSWYSCNRFEEKSGSDARDAQAKSRMSLERYLHYYNRYANHEQSARLDKDIFHRTQRKMEHLQNKSGLSWIEVQFLKDASQALQQCRQTLKWTYAFAFYLARNNQTAMFEDNQKDLEMAVENLSEMFEKPTEQLADLKLDMLNKMAYCQRRRVILLDETAKDLRDGKWEYNVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C671</accession>
    <name>A0A6A7C671_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_290545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C671"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17205" checksum="84BFD41DBA4AD0D6" modified="2020-06-17" version="1">MINIDGLNDEHFIDLFACMPNLRNFHLKNDGPIALSLAKFIAMGESCPKLVNLMMNARFDLRALPLTSPPLFPCLKLLKLNEALPGNFDKFERLGKWVAKVEKLLHNHMPRLKSLFLYDGWNIRNILLEYTFGQRVEEKDSAAPLPSVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6A2</accession>
    <name>A0A6A7C6A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_195487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6A2"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="243"/>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862218.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="531" mass="59074" checksum="F6383B1EC3D84988" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2862615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A7C6N3_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2862645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="18691" checksum="BEB00DA64653C9E7" modified="2020-06-17" version="1">MDNRSQSNYSVSSTATTVVSCGDVSTLNACDKSPIYVYNHRDGTRLKTSQAELSALLEKDRQLRCSIKPIPRGAFFMDVYQYDLWLPEERIAYVRKPNYNTNLAGVRIPWSVYIRRLFSGKSKDLYILSSDHPQPSEKEVQQGVAEISHIPKDLPRPGLPARVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6N5</accession>
    <name>A0A6A7C6N5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="75343at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="19243" checksum="B3DA8E2263469ABB" modified="2020-06-17" version="1">MALPNMPGVLPSPAQDMDPQQIQEQMMIKTMQTAMESCVGKTVVSGTMGFGLGGVFGLFMSSMRYDTPLGAGVPGAAGGTSIADLPIKEQLRNGFKDMGRSAWSSARNFGYIGAVFAGTECCIEGLRAKNDLYNGVAAGCFTGGWLARSGGPRAALVGALGFGAFSAAIDAYMRMEHIDRGADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C774</accession>
    <name>A0A6A7C774_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_280386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">trans-Golgi network membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:Golgi vesicle transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin 10"/>
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    </dbReference>
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        <property type="entry name" value="Syntaxin 6"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin-6/10/61_N"/>
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        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
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        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="241" mass="26943" checksum="F97B54D5D9327B62" modified="2020-06-17" version="1">MADPFLSAQQDLLNLLDQSRTQLQSYLRIRSSATNSPELIEARQELEATLVDLGADLQDLVDSVKAVEGDPARYGLKREEVERRRKLVTDVATEVDAMHHQLDATVHRQDAQKAAAKPTVEDGDPLAGRNDDDDDDDDDYGAWEEQRQMKLMREQDDALDGVFSSVGVLRMQADAMGRELEEQADLLDDTENIADRVGGKLQRGLKGMKYVIEHNEDRWSTLCIGGLIFVLIILLVLVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Q9</accession>
    <name>A0A6A7C7Q9_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB11a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_197663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006366">
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        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="119" mass="13341" checksum="FA8FD66CA26FC3BD" modified="2020-06-17" version="1" fragment="single">NDPPPTCEQFLRKSGAPMCTFVVDQSAPNTCIFTFEKEDHTLLNLMTCQLQKSPNVLFAAYNISHPLFPVGRMRVQTNGTVSPRMALIIAARETLAELAKLLNVFSEEVALYKAMHKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C834</accession>
    <name>A0A6A7C834_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_241196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C834"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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            <begin position="116"/>
            <end position="325"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="364" mass="40084" checksum="1D07296919152D13" modified="2020-06-17" version="1">MVNITFVDWHHLATSLTYAYSIQSLTNASTDAVSFISYTDKFTNSILGANATSELILHLPYQAFHEAGAFYRATGKLYASSNWANDLENPINVTVIDVLNGDKVTSVRYDGLQNANGGATMYYADPEGGVNGTESQKLVFCDQGDFNHPAQLIEVDPVRNKTKVLLDNFLGRNFSSINDVTQHPVTGDLYFTDVPYAYWQDFRPPPELRPQVYRFSPTTGVVVAVADDFVAPNGVEFSPDGTYLYVTDTGKLTKEIDATRPSSIYRFEVTKAGRLRNRELFAYVDTGFPDGIHTDTEGNVWSGCGDGINVWDPEGVLLGKLSVGNGGSNNFAFIAGGIYVFNNYRLFKVGMKAVGRNVRKDFGV</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
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        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22847">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="162"/>
        </location>
    </feature>
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    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="787" mass="84213" checksum="9E92527346D29100" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8F5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="62" mass="6997" checksum="142EE7AA8E1DC166" modified="2020-06-17" version="1">MLDFTFLQDERECLFPCVENLILHGILLKGAKEKDTTSEAERVLETIAPKLRCLRLGGVGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8F8</accession>
    <name>A0A6A7C8F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8F8"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="27071" checksum="A33EE44FA4910E91" modified="2020-06-17" version="1">MSWGNVHTPDLQTILANLARLSGSQPPQQPVPSSLPWPAPAHDQGSSDVSRFVNSNTIQQQQIPSPAEGPVIAPAQITTWQAGYRCVHKIARDDGQFAAKIRKLMAHQRKTEMRWFSERRDLKQRLAARVDSSAQVTSILQSLGSSGHQSETTAQTDGGKALEEYDRGLYAAQAAMDEYLASELKAMGVPFFKTNPALVKPDGEDLQDASSNTRPKWSPFIHQSELLRLQRRMVDHLEDLYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8H2</accession>
    <name>A0A6A7C8H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8H2"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="8587" checksum="61CB79695E7E2631" modified="2020-06-17" version="1">MVLGRLAHYTFDAVLFSAFLAGVKRSTGLTPSIRTETFSDSPSVKKWVDNYLWFGETIMDQSVALMSASGYFERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8I6</accession>
    <name>A0A6A7C8I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_280083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8I6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="12258" checksum="F9D7366ABE2A71D8" modified="2020-06-17" version="1">MPKEKTTSRKSAKASKAEGGKKRKDPNMPKRGLSAYMFFANEQRDKVREDNPGIKFGEVGKILGEKWKALEPKDKEPYEAKATADKKRYEEEKAAYTAGNDDEEEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8J8</accession>
    <name>A0A6A7C8J8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_274629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8J8"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="52580" checksum="2D73CBAA427E28BA" modified="2020-06-17" version="1">MALFSLPNELIHQVLAYLGPEDLARVGQVCRLLSAHAADEKLWQAQVNANLAAPVRQPDVYGSFRKLYATHHPRWFLPRHRIWFSDGYPFGKLLIARFEPSTGLIAAYTVVATRGSHVLQTWDRQPRTSVYDFQPQVSLDLEMPIVVLDGKSTLRPDGTCAQCSKETYMNTQNRMVHCSFVMCQDLPPDPLLEFVSFWPPLVFPAETRVRKFEANQSFRESETRNVSQHHFRVRRWPHHRAPGEHWCSHRLSQSLDPAADFTIRVLSGMLGDRFSGLPGELNTFSTLPASLYTPTAEKPWQGIWVGDYGGHGREFVLITQPDRKDERQLPHDMDKLQDLLRSRDDSSAIEDASQDVPLAGGRLEAIKLTGDINVPRGEYTFIAPEIGNGGLIRIADESLFRGARIVQSMGHIAEREFVQDCYIPTQLIMISHNRLAQYWESFRHVSYYQRINLEALETFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8R9</accession>
    <name>A0A6A7C8R9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">TAP-C domain-containing protein</fullName>
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        <name evidence="2" type="ORF">K470DRAFT_255080</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
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        <property type="entry name" value="NXF_fam"/>
    </dbReference>
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        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24048">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="30215" checksum="89EF7B7C97EE7B0F" modified="2020-06-17" version="1">MVIKVASSDANAFARLDRYQWAGVVVRIARLDAPASSIVQTAAQADAENTKRMLLSVLERRYEFKSKFLDLSALRADEELQKQDIFAKTSTTHKFFPAMMRVLELSFDSKTARDEAVSSVSLANNDLTDVSLVTSLSQTLPKLVNLDLSGNKFENISALGNWRRCFPDLSHLIVTGNPMESKDPEYWKTAMNWWPKLRFLNGLPVRDDQGMSLAVMPYELMAQLSVKTNMVPSYSRLCLEQTNWDLEKALDAFHNVKHTLPGEAFTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8T4</accession>
    <name>A0A6A7C8T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_193144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8T4"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="528" mass="60020" checksum="A286DAFB8F559D3F" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C937</accession>
    <name>A0A6A7C937_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase 4</fullName>
            <ecNumber evidence="4">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA ligase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Polydeoxyribonucleotide synthase [ATP] 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_211166</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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    <accession>A0A6A7C9F6</accession>
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        </lineage>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61673" checksum="AE98BC255245B2F5" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <name>A0A6A7C9H6_9PEZI</name>
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            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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    </dbReference>
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        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A7C9T3_9PEZI</name>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Z5"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="152"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2863825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="38823" checksum="E8E6ECE239AF1408" modified="2020-06-17" version="1">MTPTPIFVASIGTGGVGKAFLAQLAQLHTRLSRQTPAFDIRLILLRRSSSQVLTKDYSNLGFDIQLQSGASQVTEWPEVVKFLSSAPGKVVLVDNTASAEVGEWYPEFLKKGINVVTPNKKAFSSSQELWDKIQAASPGKVLHESTVGAGLPVLTTLNDLIDTGDKVKTIEGVFSGTMSFLFNSYMPLGGSAEGGFGGEVFRAQKLGYTEPDPREDLNGLDVARKLTILARICGLKVASSQAFPVESLIPAELEQVSSEDFVKRLPEFDSVMEKRKKAAESEGKVLRYIGKINVSKSQLEVGVKAVEKSHPMAALKGSDNIICFTTERYGELPLVIQGAGAGNDVTAMGVLADLLRIARMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAC8</accession>
    <name>A0A6A7CAC8_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_279643</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_regulator"/>
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    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="184"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="184"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="652" mass="69864" checksum="32AC595A8550D39E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE0</accession>
    <name>A0A6A7CAE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_279633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAE0"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="261"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="456" mass="51705" checksum="4D1C2D1E2E000658" modified="2020-06-17" version="1">MIPTESHPPAKPTRTPQWSAEVRQYVQRSFDPGNVVPGLAHAEVMEMLKKIITRAADEGILDTIDWNTHPLPQQLLLYHNHVTPGSGTKRRCEEVVHSGDQKVKKARAEADKISDNKGVAPDGKLFNISIRSAPFYPDAETLERRRQRFGIVNEEDSPAPMEETNNEDRHNMGPLVGTCQNLEKQYFRLTEPPPASSVRPQAVLEKSLVHVVNLWKQDHNYLFACDQLKSIRQDLTVQHIQNELTVKVYETHARIALEMKDLGEYNQCQTQLRALYRSGVNGNREEFTAYRILYVIYTCNRVDMNTVLADLTHSDKETPGVRFALDVRAALAAGNYHRFFRLYATAPFLCPYLLDMVIERERLSAMAAICRSYKPSISIRFLANELAFDADIGDKVSHDVDTGARRCLEFICRYGGEELFEEQADGNVHFLSGKAGRLFEQAKVAAFQSVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAR0</accession>
    <name>A0A6A7CAR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_253970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAR0"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="475" mass="52325" checksum="87392D7405735E6A" modified="2020-06-17" version="1">MTTEKSDSVAVEDAPAFQEDAGLDDRFRRKFDLHILPWIFLLWLLAFIDRSNIGNARIDGLAKDLHLTGEKYNVALTVFYILYILVDIPSNWVLAKVGGGHYLPILAAAWGIIGVCMGAVKSYTGLIICRLLLGACEGGMFGGIILYLGMFYKRYNLMFRLGIFYCAAPLSGAFGGLLATGLARIHFHGYNGWPWIFFIEGAMTILVAIVAYFFLPHTPSQANFLTPREKDHAMRMLHEDMHGAASPTHLREENDHFTLSSIRLALLNFNTIAMSLIFFLVLIPIYSYSLFLPSIIKGLGYSNVKAQLLTVPPNFLAFLSVIFISFLSDRIKMRGPLILSCATIGAVGYIMQLASHSPGVKYAGTFFVAAGMFPCSPLCLAWLSNNLAPHYVRATGLGLQVAIGNCGAFVATFTYLSKHAPKYIEGHAINLGAIGLLLIGTVITLGYIKMENKARLNGKRDHRLEHGNEDLGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBH1</accession>
    <name>A0A6A7CBH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBH1"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="542" mass="60572" checksum="0DBD2C7E3A7475D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBN5</accession>
    <name>A0A6A7CBN5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2864577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Ribosomal_bL19_sf"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="21284" checksum="B49CF269BF4F566D" modified="2020-06-17" version="1">MRRSYKTAQPPTLESIYGRFRPQSPPEKGLKVPVFPPHQTLMDVCQDPDSEATKSQLKQLDPDGTRTSLFSSKNPDRVRTGDTLSVRLSSGKVVTGVVRAIRRKLAPKHWGIQLRLLDTEAEKWFLIFGRKVKGIELMQRRIQVPNFSGLRKPRQTTHSVERTVQRHLKLQGGVFANNSMRFLAPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBV9</accession>
    <name>A0A6A7CBV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_279646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBV9"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CobW-like, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
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        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="39628" checksum="812F737BB188340B" modified="2020-06-17" version="1">MEDDEPPQLIATVPTDEESEGAFPKVPITIITGYLGSGKTTLLNYILTARHGKKIAVILNEFGNSGDIEKSLTVNQGDTQAEEWLQLANGCICCSVKDSGVNAIENLMSRQGAFDYILLETTGLADPGNLAPIFWLDEGLGSTIYLDGIVTLVDAVNCIKSLEEPVAEERAETDHQHTPLSIAHLQISHADVIILNKSDLVSSAGLQAVKDRVRSINPLAKIEVTNHARVTQLEGLVLDLHAYDRVDVDFASKGHSHLDPSITSASLHLPVLSVGQLAKLDEWLRALLWAGTRQETTTQDTGEVYRIKGRLPLVNGEMKLLQGVREVFEIFGAEDKITAERGDIVVIGRKLPSSLQQSLTDALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNU5</accession>
    <name>A0A6A7BNU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_261165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNU5"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025331778" evidence="6">
        <location>
            <begin position="17"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="521"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="692" mass="75573" checksum="628577DD95C58E17" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNW2</accession>
    <name>A0A6A7BNW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_279516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006066">
        <property type="protein sequence ID" value="KAF2857110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNW2"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF103">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="35027" checksum="A1BA23DA30A9D893" modified="2020-06-17" version="1">MRPHSLLLRSLSHKRTPPTQGFNPRPLYQAKAPTHPVQSGINDPHRDAHRSNSSILRALPPILSKFTLVGKHAVVTGGARGLGYSISQAFCEAGCERITLFDVQASLGREAARRLGDDTGVKAEFFAVDVRDEEAVCEVVGALERVDVLVNCAGVADSNIKAESYPIPTFRNLIDINLTGTFIVSQAVGRRMIASSTKNSPTAVSPARSSIINLSSIAGSIVCHPQEQSAYNASKAGVRHLSKSLATEWAKYGIRVNCIAPGYMDTALNRVPELDALKDSWREGIPMRRLGQVDEIDGVAVFLASEASNYVTGECVTVDGGFTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ28</accession>
    <name>A0A6A7BQ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_273325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006046">
        <property type="protein sequence ID" value="KAF2857393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ28"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="38833" checksum="F6FD51833E30EE90" modified="2020-06-17" version="1">MPEFDPSSYPPFPSSPSYPCVSLSTISLSALESHSPTEESRAFEAFKTRGFIYLDLSSSPNGEAILHGSETIGRIAEETFSLPLDEKLKYLPASKDLFGYKRAGATKADPSGARDTAEFFNVSKNDMLKPPSEMDRKWPEVILKEQEVFARYCRAAHTVGMDLVRMLGRRLGIEEEELVKRHRIDLPSGDHIRLTRGPARKDPKMPEIQTPSHTDFGTITILMNWLGGLQVWSESARSMGPLEPDTPGEWVWVKPKKGCAIVNLGDAAVRFTNGVLCSGRHRVTPAPEKQGLYTRYSIVYFVRPNDDAVLQVLEGEHVPKAEKDEEAVPAKEWIYRQTAALGNNTLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQD1</accession>
    <name>A0A6A7BQD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_171302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQD1"/>
    <dbReference type="OrthoDB" id="5421637at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025546851" evidence="2">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="314" mass="31951" checksum="0D149A08BA851C05" modified="2020-06-17" version="1">MMQKTATTLALLLTAVAAECPEGHKPGQHHVSFTLPYRYEDVVNVVGDYSDLSWAGATSAVDVEDEWKPGTSRSYTMLGEKFVDTLTTFMRSQSGPYIQVHSVGPVEFAHSGLKLRAESSAQAWWPACEGRATWADINVDYCATDLEDAEKVWSTLHSHAAASVRNKLGGQMYTGCEALGVFARDVNGTTNGTNTVQPLHTVGSGTVGNTVGNTVGNTVTGGGSFKTSATGSRIGSATATASSAATSSAGGAGAGAGVGASSTGASSPAETGGSGSDECGPQSTTTCAHNGASSTNINSFMAAAAAFIAVSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQP4</accession>
    <name>A0A6A7BQP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006059">
        <property type="protein sequence ID" value="KAF2857207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQP4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28715" checksum="F7F16EAB2E450960" modified="2020-06-17" version="1">MAAAEYYNQQQGYNAQQAYPPQQGGYQAYTPPQQQGYAGGYVQGYPPQQIAPQQGYQQQFAPPPQQQTTHLAPLGGNPPYPLGGTPYGQSTPRPHSSPGHQDRYSRRDSRHRPEKHARFADEEKYRTSSCTPTCYEDGRKGRGEYDRRGRARYSRSQSRSRSRSRHRDRNRSRSRSRSRSRDWSRDGSRDSHHHHNQKGKNSGVGTFLGAGGGAVLGDAIFPGLGTLGGAILGGLGGRRFEKEREDYRYHEGERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQU4</accession>
    <name>A0A6A7BQU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_261152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006073">
        <property type="protein sequence ID" value="KAF2857069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQU4"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="451"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="702" mass="79352" checksum="392D32B4C769DFB5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQZ3</accession>
    <name>A0A6A7BQZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_223617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006051">
        <property type="protein sequence ID" value="KAF2857307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQZ3"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12978" checksum="C0A30F6A10092247" modified="2020-06-17" version="1">MTYHAHTGFRIGMALAEALDEMITSRRIEPLLAMRLMEKFDQCMSSVLSQQVRNKMSFKGKIDRYRFVDDVWTIILNDVSLNVADAGIRTDSSPDITVARIKIVAIRSKEARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BRG3_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRG3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="425" mass="47690" checksum="8DB5155F2B456984" modified="2020-06-17" version="1">MFFRDNPSKRSAGLSRYSLSLYSTTAEQAIDRLGSTPKARRLPQNLISLHEEGFIRDEEDLQNIDKALAALEGRPVEVEYRSPPRKQSFSIKPPVPLPQILAPQESPPKQKKCGILRSLSTRAFGRTTKKTAPTRSNSNSTRPKIRIVPGTFIDGANDEHTRTSPMNIRTISLEEACQRQVDEINKYYNVPSPVPWKDVGLYETKSGASSRSVLNRETKWEDFISPPAERETGMRVSSYSFLSTTWDERGGEFAAGDESPAREDIDDEQYIPALQRVLSFDELSLKPAPLNVAKENDKRSQPSGCRDLLKDVERNLPFSPTSPDLDQSISFDLSDISAIGLPTPKKAKLRAEGARLRELVNWGNAHPSSPVVDMLEHDGHTSWRVTEWKGMGVVESYRVKVKKDEYGQEYWRQAVGVLGGMREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRL5</accession>
    <name>A0A6A7BRL5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRL5"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15078" checksum="52462751BEB92C93" modified="2020-06-17" version="1">MHTGTHLLTIITNGLWGLCIVKLTVPVLPFKISAEIHHHRSLQILAQMPVMGNAHGIPARPTPPQSVESSTARRGRGLASAYKGTKQGPFLMWSGGDDHIVNCIGSPEKATNSGARTDCIAQLSNWERWKFEQIHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BRT0_9PEZI</name>
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            <fullName evidence="3">L domain-like protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRT0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25270" checksum="D500B72E29CAC58E" modified="2020-06-17" version="1">MIDRRSNYFLEILKQLNQLQSLDVKSQLPDKRWMDYNFLFHVFDPRTCIRYFDAIQCYATTSTWNKLAHNLSSASSNLTDLSIGLRSRDARHLVTFGRSLRALTFSILDVGDGPYEAIGDLQCLTSLKISFQGELPLYPHHLESLRSPVNLQLLNNGAGRSELPLSEGLADMDFTLLFLSMNDLRDLSLNMWDADQITPKMIFTLGKACRKLKSFRAMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY3</accession>
    <name>A0A6A7BRY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_148527</name>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="25511" checksum="AF8914B190183DDA" modified="2020-06-17" version="1">MARAVGPRSLKEQGDANAHAHPDHPLRPFSSAKCRSVGRFVADTTYRLTCHPPDVSSSGRASSQFPTTSLIPDSLISLFSDYLAMNTRQREKRKALEHFSDSDDADVPQESTSASKKQNMQVGSGKKQTKTTASGKKAAKSVTKPSKKGGKGQRPATGKGKEPGQRATSNSADEEDIVSEGSEAFMSQTSQDSHFKSSESGLDDIDLCRRGEPPRTRAEWMSTTKVFTQLLLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS39</accession>
    <name>A0A6A7BS39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="84"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
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    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="584"/>
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        <location>
            <begin position="662"/>
            <end position="772"/>
        </location>
    </feature>
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            <end position="1047"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131534" checksum="FCADF1C67BD0F936" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSE6</accession>
    <name>A0A6A7BSE6_9PEZI</name>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR005062">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
    </protein>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSI7"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000059">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="286"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="577" mass="65375" checksum="D8CAF07DD31A37D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSJ3</accession>
    <name>A0A6A7BSJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_205608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSJ3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="120" mass="13384" checksum="4DF27E0F2EF7C89D" modified="2020-06-17" version="1" fragment="single">GHIIDYCVSKILFATSGVCTKLDTDSDHHTLPIHVPGRETEPVERLHYRVHDKKLPEFADVIALHMSGMLSNASTPKAVEQQLRRFEGLWEDTLSAVGHLAQERARSAPGLTPECQHAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK3</accession>
    <name>A0A6A7BSK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_221567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="9">
        <location>
            <begin position="1974"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="10">
        <location>
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            <end position="3185"/>
        </location>
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        </location>
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        <location>
            <begin position="1951"/>
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        </location>
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        <location>
            <begin position="97"/>
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        </location>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="3211" mass="361296" checksum="21FDD28F6B493D2B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSP9</accession>
    <name>A0A6A7BSP9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
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        </recommendedName>
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        <name evidence="14" type="ORF">K470DRAFT_260500</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
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    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
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        </reaction>
    </comment>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
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    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="156"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="194"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="196"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="231"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
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        <location>
            <position position="243"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <ligand>
            <name>Mg(2+)</name>
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        <ligand>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="269" mass="30476" checksum="BCBF7C232EDF0E19" modified="2020-06-17" version="1">MAVAASVIPPLNERPYKNTICLFDVDGTLTPARRTVDPSMLALLSQLRHKVAIGFVGGSDLIKQQEQLGTPSIPVSSLFDFCFAENGLTAIRMGKPLASHSFIKWIGEDKYKELVKFILHYIADLDIPVKRGTFVEFRNGMINVSPIGRNASVQERIDYEKFDLEHNIRKTFIQKIQEKFPDLGLTYSIGGQISFDVFPKGWDKTYCLQHIEADQKLPDGVKFDKIHFFGDKTYKGGNDYEIFEDPRTIGHTVTKPEDTEELVKKLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSY3</accession>
    <name>A0A6A7BSY3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14104" checksum="E207785FE92660B7" modified="2020-06-17" version="1">MARFNEAHPLQHRGSMSSFGSVPSTPTSTRSRSTSISSLDTIADAPDLESEAAEAERIERLQKATEKLVEQSQSERAIIDDVGRRSSLDAPRSASWSLSRASRERKRWSVCGGERGLLEDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT23</accession>
    <name>A0A6A7BT23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_272580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT23"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="204"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="395"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2858283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="598" mass="65387" checksum="AA995154AFE3B1E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT94</accession>
    <name>A0A6A7BT94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_133409</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT94"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="255" mass="28215" checksum="A3B5286DBA2A640A" modified="2020-06-17" version="1">MDKLPPPFSSTTSEDTVLISQGAEALIFRTPFLDTLAALKVRSPKKWRHPTLDMRLTRSRVLAEMRVLVKLAGGVQMGAKGKKNPGPTVPKVRVPVVLGADWESGWLALEWIPGKSLKQTLWDVHPAEKERRVEELLRQLGVLVGRLHAAGVIHGDLTSSNVMVSEDPHSALEPAKADELVLIDFGLATNSVQDEDRAVDLYVLERAFGSTHPLLEYRFQTVLDEYVAVLGSNAKSVLRKLADVRMRGRKKTMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTC2</accession>
    <name>A0A6A7BTC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_133994</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTC2"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="14">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2858383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="460" mass="49866" checksum="90848543CD1F05B2" modified="2020-06-17" version="1">MTISKIHARYVYDSRGNPTVEVDIVTETGLHRAIVPSGASTGSHEACELRDGDKSKWDGKGVLKAVANVNEKIGPELIKSKIDVKDQSAVDAFLNKLDGTENKSSLGANAILGVSMAVAKAAAGEKRVPLYAHLSDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSDAPSFSEAMRWGAETYHQLKSLAKKKYGQSAGNVGDEGGVAPDIHTAEEALSLIAEAIEKAGYTGKMKIAMDVASSEFYKTDAKKYDLDFKNPDSDKSKWVTYEQLAQQYKDLAAKYPIVSIEDPFSEDDWEAWSYFFKTSDFQIVGDDLTVTNPAFIKKAIETKACNALLLKVNQIGTITEAIQAAKDAYGAGWGVMVSHRSGETEDVTIADIVVGLRAGQIKTGAPARSERLAKLNQLLRIEEELGDKAVYAGKHFRNSVNIRAVARDFSKLGLYTSLLQSICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF4</accession>
    <name>A0A6A7BTF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_127680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU81"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="516" mass="58037" checksum="BBBA5C0177A28319" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUB4</accession>
    <name>A0A6A7BUB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_259647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUB4"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="9">
        <location>
            <begin position="659"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="950" mass="107535" checksum="C530E25BAC5C4705" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUQ3</accession>
    <name>A0A6A7BUQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein FYV10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_278553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUQ3"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="400" mass="44852" checksum="BD5F4871880DD661" modified="2020-06-17" version="1">MDENRLDADVQQALERALLRVPHERLRLNLKSAQRHIEVAKTQKTFAGDKDVLQADRAVEMIDVTLGKARTLKQKLGSLVQEEQKLCSQQRARIEHLQDLHAISSVADPRYDGWARTRLNRLLVDHMLRLGYVEAAQKMAQETETENLTDIDLFVESSRIEKSLRKGELKPCLAWCTEHKQMLKKLKSTLDLDLRQQQLIESARSGDSSVLVDALKHARTHFSSKSAPGDQKFGLEAGGLLAHSPDMAVQPYHGLYSPSRYAELADKFVQTQLELVGALDVALLHPVLLSGISALKTPQCSSARREINNTKALSMAVTSSTCPICSPELNELARPLPFGHHDKSHVDEDLVVLPNGRVINHGRLQLLNQKLKVPKGKIRDPFSTTGEEWIESVVRKVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUT4</accession>
    <name>A0A6A7BUT4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Pathogenesis-related protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_196524</name>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="17032" checksum="A5DFF3FA7F2E8324" modified="2020-06-17" version="1" fragment="single">SYKGKCLSAHNVHRANHSAPDIQWDDGLASTAAKIAATCNYAHNTEMDGGGYGQNIAAGIKPEHVDAVITNLFYNSEVSAFDGNYGQANPSSNFESWGHFTQVVWKASGQVGCATQDCSSQGLANAGGGVPAFFTVCNYKSPGNFAGEYDKNVGRPLGHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUV0</accession>
    <name>A0A6A7BUV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="485"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="351"/>
        </location>
    </feature>
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        <location>
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            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
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        </location>
    </feature>
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        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="591" mass="70354" checksum="C3A17DF341F5A324" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVK9</accession>
    <name>A0A6A7BVK9_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="29823" checksum="6B2CC65F88EFF7A5" modified="2020-06-17" version="1">MIDFDNDDLGISPLQDELTSVLTLRFGCEVWPVTLPSSSSSIWAPMYSMIGVFDRLIQAGRAKEGNLVILVFSGHGKLCGKIYSAVALLAANGDFSRNTLSWHNMTELLDSTGCDQIHLLICCHFGEVSSPNTEVFAATSATKATSRSLQTDITRALIDELKVANEPILLPSLYAEANYQQQESRVRSSASLCRPTLDADDVASFKRPLQKMVPNATTGLELAVEGVFHGDSSVDLITVPVQIWCYLRPTTKLNFVAHVKSGNELLRWAEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVX7</accession>
    <name>A0A6A7BVX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVX7"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="14724" checksum="226CBE757A3BB98B" modified="2020-06-17" version="1">MAKTLNPSKSPLPLTASQEAQVQEIYHKRVRAKCADEVRDFALCCKAHNFTATVVCRSAQRVMNACMQQFATLEELDAARKEWFERIPERQKERELKEAKRKEQEKFHKDWWDREREWKKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWH6</accession>
    <name>A0A6A7BWH6_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Putative siderochrome-iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_300311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWH6"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="589" mass="65094" checksum="543AA4271F274494" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWI1</accession>
    <name>A0A6A7BWI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_271648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWI1"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="391" mass="43252" checksum="D705E016FABDDB93" modified="2020-06-17" version="1">MSSSTKGVHFGAGNIGRGFVAEFLHNSGFEVVFVDVMDAVIDSLQKTKSYTVTEVSDEGEHDFTIDNYRALNSKTDMESVIQEIATADTVTCAVGPNILKFIAEPIAKGIAARKAEKPIAVIACENAIGATDTLRRFIEEKMDSETKDKIGELARFANSAVDRIIPIQPDNAGLNVRIEKFYEWCVEKSPFLPMEPPAIKGVHYVEDLKPYIERKLYTVNTGHATAAYYGYQYGVKYIHDTLANQDLKIKVVEVLMETSDLICTIHPHVSREEQAEYMKKIISRFSNPALRDNIERVGRAPLRKLGRRDRLIGPAAQLADLGQSCKALLGAIEMALRFTNVPGDDESVQLSKILKSDDATTATKKITGLEESHPVFNGVSDKVKKVQNEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWK6</accession>
    <name>A0A6A7BWK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_100337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWK6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="42594" checksum="C7D544625B4C5568" modified="2020-06-17" version="1">MSSAADQGSQKRKRGRPRKRSKLSAGRDTSPQSSSQSSEYDGPPRTRRRTVSKTTASKKQADSPPSQDNILKNDAADTRDTLTKSGSTTSLKSRLKSSASTASTPAAAVSGKRVTRKSVNVSFSENVNDTPGTNTRSSTRLQNNSNVSATQAEGDGNSRRSSARLNKGVAPSPSATSAESPESNRRVSTRSQKAAVPASSVAEVTSKVIDSEPASQEVQESFQVKNPTANRPWARKGKEPARSPSPVRTRRQRGSNVAQAIVETQSDGADEADVAAGAENSDDDIDEGSIHDSDVRSAEFEKQYDPVNDDKKIQSSTGHESKGEGQTTNTSRTETLYDPLRPWRIRGFTTAMRAEQERMYNREERYTLAGGWACTEEYQKLKVCKSQIEVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWM8</accession>
    <name>A0A6A7BWM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_248849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWM8"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="311" mass="35512" checksum="AE0609E4738B15A3" modified="2020-06-17" version="1">MLPLQKIHPKNARTKRYLDNKAPQLNENPRTTLFLRYTTCSQILQLVLTDLYNIKKPLAVRFSKKNDIHPFESESSLEFFSEKNDASLAVFGSHSKKRPHCLTLIRFFDYKVMDMLELLVDPETMRTLSQFKNTKPKAGSKPLLGFSGSAFDSPTANAYTLAKSLLTDLFKGPDVDSVNVEGLRFLIHFSVDEVADEEVKPMIHMRCYLLKTKKSGTSLPKVEVEEIGPRIDFRVGRSKAADPETWKEAMRKPKTSEMKTKKNIGMDIMGDKVGRIHMGQQNINQMQTRKMKGLKRGRDEDGAEEEPQSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWY1</accession>
    <name>A0A6A7BWY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_207937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWY1"/>
    <dbReference type="OrthoDB" id="3049701at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1870">
        <property type="entry name" value="Fic/DOC protein, Fido domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053737">
        <property type="entry name" value="Type_II_TA_Toxin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="5890" checksum="838C89021FC23225" modified="2020-06-17" version="1" fragment="single">NAAHYGSETRLHMLVAILASKLILNHACFNGNKRTALVSANMFLRLNVYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX87</accession>
    <name>A0A6A7BX87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_271248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX87"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="413" mass="45178" checksum="2FF35BCA7E911522" modified="2020-06-17" version="1">MSSTDTSDYIGDIIKAGQSEMSEDGGGPKVDKGTKGCQVHGVGNVTGGGQDTVPAQVTEAGTRAVGQSIKAGTSLGAQYTEACTNTGGQPTKTYSIAGRLFTEEGKGTGHQGTTVGRNVKELKPPPEFYSNDLDDQLQALVELFPIMREGRPLTKSAIPRLVEFIKISNKVLQFKALAIISLMAPELKEDLIAAGAAPALENLILAAPVLSQRAICILAVLSGGGKACCDAVIEANVLTKTNLSDLLLLPSIETQRAVALLFRNVCYYEYFGIEPDWEKIRPAFAYFPRLIISPDPEVLVHICYAMHSAMRGGIKFRSEFPRYLVELLSHSTWEVRCAAAHAISRMTVLMSDKLRNHLIDECKVLEPLETMWHGNGPEVEKDIDRAMENLCKTDDLWIPERWRAITPDMLDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXA8</accession>
    <name>A0A6A7BXA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_282854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXA8"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="19230" checksum="00EA99772F875D4F" modified="2020-06-17" version="1">MFFVKQLEHRVTLHPSFFARCAEEVVLNKLYEDREGQHIGNMLIIAIIDVLEISEPKIMPGSGLAQYDISYRAIVYRPFRGEVVDAVVTNVLHTGFFASAGGLTIFVSKSLIPENLKFTVEGATPCFSDNEDQVVEQNSQVRLRIIGIRSEPSKMYAVGSIREDYLGPFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXG3</accession>
    <name>A0A6A7BXG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_271576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXG3"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
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</entry>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXU0_9PEZI</name>
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    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="3">Telomere</location>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR16308:SF13">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
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    </dbReference>
    <dbReference type="Pfam" id="PF02845">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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</entry>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYJ0"/>
    <dbReference type="OrthoDB" id="3911405at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="57000" checksum="044364C72107993E" modified="2020-06-17" version="1">MDNSVMPSSPPSSSRYELDLDALQGASETFNPAMMPRIECVQSDDIEGPTNFTIDMMRLMHSRRPAHGEHDGNHHQNGNHHQRDADHDDHGDNTEHEQELRVPSSPQERLCPSASSRHTPDESPPKESANQQRHEDSVWPTLHVNTPPPKPKNIAMGEEEFHSDFTPAKPSSPTLSPNIARRAVPSAQFVDQDLILQLETARSRCNALEKHNAMMEEGIEREKRAHAAEVQRLRQEILSAQRAKKAETTRRTEVEAQLASTRDELRRQTEDRDILLAEVDRQRKIAKVFREASEESATELAKSRVKESAAERAAERTVERAADRPSSPREKTEAGERSSTRKMSQPNSEASSSSDLQRALTLAEKLDAQLKKAQALLQSQQVKYEKALATTESAHTARLNAAILDRDQVADKHTEEIKKLKDIIKAKDEVNEEVDRRVDNAMRKRESAWKQKEKDWLEERKLMVDTLFTLWGEKECGVENNKDGKQQYRYKYVKRSGVGNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ17</accession>
    <name>A0A6A7BZ17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_277069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ17"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="157"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="45263" checksum="076FDDA4089A5669" modified="2020-06-17" version="1">MKGSRSEFCRDLLNNKCYRGRGCQYRHHGPERPAGFMASCELYPPPEKCLTLVVDRYTEGVFSDGFITIDVRCLSFPKYMRPPKQDKVGTQTHRLRCPKKTPYDVFKRRFHESQQKHGKEVLFWVDHADPPSAVICGDTELLRTVQREFDPERKLASAKYCAICCEDCADFVRLLYCKHSCCIYCFRRFCVTQDGSKLPIECFDPNCDKLVPMRQMRLHLSYKQLLDLSRLSVARHVVQHPARFLRCPTPDCQGKFRLDGKRVQTCKLCSKDICAECHSKDHPGESCEDFRKRTGNDPEQLANWMSRNQTKKCPNCDTLIQKNGGCDHFQCMGCHMHLCFKCLAVFKDQNPAYKHIISKHGSYGDTEVEAEVARINAIHRAEEDVDNALLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZB5</accession>
    <name>A0A6A7BZB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_247655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZB5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="419" mass="46677" checksum="0A31B43935FD8269" modified="2020-06-17" version="1">MTTRYRVEYSLKTHRRDQFIEWIKGAMAVPFVLLAHPGMTGTSVDREDHETTGSVDQSLTRSRYGQILRDIERLIAEHRSSAGSGATSRLQALVPSIGQFFTQLPLQDAFEYQDAKRIISARRFVAPSFNDIRLILNTAQIMALVREARLELITFDGDVTLYNDGEALTPTSECILRIMALMRRGVRVGIVTAAGYEDAESYHGRLYGLLEALAADETFAKVDKGNLIVMGGEANYLFAFDADTVPSRLKRVEDGQWKLPEMAGWTEEAIADLLDVAEQALKRITSMLRMKVKVVRKPRAVGIIPADPKARLPREQLEETVLFVQRTLEHSAQGRKIPFCAFNGGNDVFVDIGDKSWGVRACQSFFGGIHPGRSLHVGDQFLSAGSNDFKARLASTTAWIANPEETCQLLDEAVEFMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZI1</accession>
    <name>A0A6A7BZI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_264772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZI1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="26085" checksum="E439582392C8F862" modified="2020-06-17" version="1">MSSRTRLTFAVALDDSGRTVDLHISDPSRIAADNLALATWGSSQVLANTLHRLHVDNAKTILELGAGTGIVGMTAAAVWHSKNVILTDLEPILPNIAASIKLNEQTLAEHGGAVEFGLLDWYDPSTLILGASQNKVSLLDVGVILAADTVYSEEHPQLLVNVVSQRLQKSSAARFVMCYPLRIGYLDHIRDLWQRLEEAGLECCEEGREQLDKSWDDDTPYEWCVWQWQHLKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZU6</accession>
    <name>A0A6A7BZU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_197914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZU6"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="272" mass="28030" checksum="5CC23AEAAE71D092" modified="2020-06-17" version="1" fragment="single">MSAQADVELRNFDRIFRLDGKVAVVTGGSRGLGLHAASGLLQSGCSLVFITSRKKTACEEACAALNALGTSGKAISVPADLAMPSEIDRLVAAVSKHTAHVDILLANAGATWGSPFDKHPESAFAKVMDLNVKSVFLSVQRFAPLLRKRATLEDPSRVVITASVAGIGVGAIGEHATFGYSASKAAALSLARNLSAELGPQHILTTAIAPGFFPTKMANGLLEMSGGAQRLAEATPNGRLGTADDFAATVVYLCSRAGGHVNGSYIVLDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0K4</accession>
    <name>A0A6A7C0K4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_216975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0K4"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="422"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="778" mass="87701" checksum="42628F87D3E43999" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0V0</accession>
    <name>A0A6A7C0V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_257471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0V0"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="28190" checksum="0237965D4A1B4AAA" modified="2020-06-17" version="1">MASNLQQPGQVIQRAPSCRVGPGYRPHDEKPAATVSSTVLHENVHIMQQTPQLIALLTMIRDKRTTRADFIFYSNRVNRLLVEEALNHLPVLPQTITTPVGRTYAGVRFEGKICGVSIMRAGEAMEQALRECCRSVRIGKILIQRDEETSKPQLFYDKLPEDISQRWVLLLDPMLATGGSALMAVDVLRSRGVPEDHILFLNLIASPEGTENFARQYPKVRIVTAFVDEGLDERNYIVPGLGDFGDRFYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C129</accession>
    <name>A0A6A7C129_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_215667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C129"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="32599" checksum="3FDCA326642ED8FC" modified="2020-06-17" version="1">MRLFTTFRTISPQVFNRHFSSQRTTCAKRPYRAALVLIAGGLTTYTFTRPSQQADNFIPYTLTHKELVSHNLAIFTLRPSTAQQLNYPADSESKIQSIEIKQPQLQISRRYTPLPPMSGDEIRLLIRNAVNGEVSSYLHRLPLGVKVHVRGPVTEFALPQDVGKVIFIAGGTGIAPALQVVDASSDGMDVLWGCRTLDERQGAGEMVERYMKAGKNQVSFFVDQEGSIISPKDVTLRLKGRDASRGLIFVSGPDRFVEYWAGTKIWRDGRETQGPLGGCLAKMDLSGWEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1F2</accession>
    <name>A0A6A7C1F2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_216851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1F2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="26939" checksum="A0EC974B8FCBA82E" modified="2020-06-17" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAVGVTTATGTVLGVEKRITSTLLEASSVEKVVEIDRHIGCAMSGLQADARSLVEHARVTSQSHAFHYAEPIGVESCTQAICDLALRFGESASGEDEASIMSRPFGVALLIAGYDENGPSLYHAEPSGTFYRYDAKAIGAGSEGAQAELQNSYHKSLTLADAEELVLRTLRQVMEEKLDAKNVQLASVTKDRGFRVYSDDEMRACVQRIEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1M5</accession>
    <name>A0A6A7C1M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_269928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1M5"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="412" mass="45794" checksum="151F154B08C9BEA6" modified="2020-06-17" version="1">MSWLCSRCRQQLLFRLPRRWTRLQSTASLPEVPLGLLSRAQQLAAEHDSLNRKIAEKYDAAVAKRIGELSPTVSAVREYEKARSAWDELCSLLQSPDRELRKMAEDEVDMAKERVSLASAAVKSSLVPVHPFAHLPCLIEIRPGAGGDEAALFAGDLVNMYESYCAWAGMKTTRLQYETRVGLVAGTGNSGNNAHVQNAVIEVDSPGAYGRLRCEAGVHRVQRVPATENKGRTHTSTVSVIVLPAVPVDEGGADNFNDPKSDYYVAPDEVKLEVMRASGAGGQHVNRTESAVRLTHLPTGTVVAMQETRSQMQNRERAWKLLRARLAQRRREEREEEMAKIRRSAGAGQSGRESKVRTYNWNQQRVSDHRSGLDVRALDAVLEGGDALERVMDSVRGWMAERDVAEEVDFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1R3</accession>
    <name>A0A6A7C1R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1R3"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="427" mass="46339" checksum="D998FAEB78470318" modified="2020-06-17" version="1">MDHYRPPGRSNRTGRNQTNNEVFEGLPVKQWSRQETRVSLAAPALGSSDGKDDRWGELPMPQDYQLLQPWTQHILRLARTGRTGRTGSSGAKRKTDCADEEDAAEEDEAAKENNNRAFLTRRWKITPTALQKPEHKHFEFLARRRKGMPSLYGPAGADGVAPMRRAKVRKTAHDGEVLVYEALVPQGQLAEGEITDAAELAELPPALTAPPGTYVEGLGIANEDGIVIVAETRRKNRPPPKKKGGPGRGKKRVTFINPDGSTYTTIVPNATKIVPQPGQTVKHVSKGEEIPVDVTPEQAALQQQESGESDSEDSTAGVETATVKSGTPSRRGMRRISSSPDEPLIQQVDQKDDTVQPDDGTDVPDKLGIDPVPMDVHVSVSDPAQENIVPLGPGVLDKVEDIPTQPPGASQEDLPALEVGEDLFGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C212</accession>
    <name>A0A6A7C212_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_215011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C212"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="262" mass="29397" checksum="66E8949303FA9F56" modified="2020-06-17" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGAYAPKASPGPHKLRDCMPLIVFIRNRLKYALNARETKAIVMQRLIRVDGKVRTDATYPAGFMDVIGIEKTGENFRLVYDTKGRFTVHRITAEEAEYKLGKVKRVQLGKGGIPFLVTHDARTIRYPDPAIRVNDTVKIELSTGKIQDFIRFDTGVIAMVTGGRNMGRVGVITHRERHDGGFNIVHIKDAVANEFATRESNVFVIGKDKPWISLPKGKGVKLTIAEERDRRKAYAQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2D8</accession>
    <name>A0A6A7C2D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_299480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2D8"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="292" mass="32760" checksum="7135D09266338050" modified="2020-06-17" version="1">MSQDPRALLQQADKAAQSASGGFSFFSSKTDKLENAVELYTQAANAFRLQKDGRMAGQTLEKAAKIQQSQLNEPDDAANTLVEAFKGYRKEDPESAARCLEQAINQYTIKGNFRRAAGHKQTVAELYEIDLEDMKRAAAAYELAAGWFEEDGAEALANKLYLKVADLAALDGDYAKATSLYERIAKSSINNNLMKWSVKDYLLKAGACHLCSDDNVAIEKALSSYRDLDPSFPSTREYQLLIDIKDSLTECDDEKFSDKLFQFDQMSKLDKWKTTIFLRIKEIIESRGEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2L0</accession>
    <name>A0A6A7C2L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2L0"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="116"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="624" mass="69675" checksum="338C42C19B4F7EF1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3B9</accession>
    <name>A0A6A7C3B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_215436</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3B9"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="24201" checksum="87DF0DC1D3F4E9FB" modified="2020-06-17" version="1">MTQQHWQVSSLSPKRLYLILYNLVSSFLWSIVLSRAASFALTKGFNHTYQGVGEFTKWTQTLAVLEILHAALGIVRAPLMTTVMQVASRLLLVWGICHNFPQVPASSLAYTTMLVAWSLTEVVRYSYFAINLSSGNVPAFLTWARYNAFFALYPLGISSECWLVGKSIGPAAALNPVNRWLLWAVLAIYIPGSYFLYTHMMAQRKKVMRAQVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3H5</accession>
    <name>A0A6A7C3H5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_213883</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="250"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="500"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1042"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="62"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1226"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1246"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1283"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2861903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1308" mass="149453" checksum="5E9EBDD185BE26E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3W3</accession>
    <name>A0A6A7C3W3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_275548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
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        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="548" mass="61170" checksum="50686509BC28926A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y9</accession>
    <name>A0A6A7C3Y9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_275691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="9209" checksum="0FF960D18BBBB8A4" modified="2020-06-17" version="1">MRTTVMRSAGMKFPGLYRPNRVPEWQRLFQNHDGVRQWNKGPRAKMMLYPYYALMITTSGAVTYMMCRMVLGHKTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C439</accession>
    <name>A0A6A7C439_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_255981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C439"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19465" checksum="D5F97A63F4C7FE64" modified="2020-06-17" version="1">MATGLPAGWEVRHSNSKNLPYYFNNQTKESQWEPPADTDSETLKHYMGQYHTAKSGPTSIAPTNLEGKIRCAHLLVKHNGSRRPSSWRQANITRSKDEAMNTIKSHESKIKSGATSLGDLAALESDCSSARKRGDLGFFGKGDMQKEFEDVAFTLSPGEISGVVETASGLHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4C5</accession>
    <name>A0A6A7C4C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_228495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF732">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="621" mass="68669" checksum="9FD6BD932616E647" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C522</accession>
    <name>A0A6A7C522_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_206490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C522"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="78" mass="8715" checksum="40D525F5F029740D" modified="2020-06-17" version="1" fragment="single">KCSEAEDWNTKALQRCEAWPKPQHSVLHIVLSSLGVLLAEQNEHEKAVAVYEKLLRSDESTLGPNYKGALETLRELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5K9</accession>
    <name>A0A6A7C5K9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="383" mass="41575" checksum="B3FC1760212063EF" modified="2020-06-17" version="1">MGGLLTLDSFVAVFPEIDTRGATGTSASATKQGISIGSYNLGCFTGAIACIWLGDKLGRRWTIFTGSSIMIIGAAIQASSFSLGQLIAGRLITGFGNGLNTSTVPAWQSETSKSHRRGQMVMIEGAMITCGIMISYWIDLGFSFAKGSVSWRFPVAFQIVFAIIILIFILPLPESPRWLILKGREDEAVQVLAALSNLPPEDEYIQSEFLAIKESVIETSQGGFKDLFTMDRDRNFHRAVLGYVNQAFQQISGINLITYYAATIYEQSIGLSGFMSRLLAACNGTEYFLASWIAVFTIERFGRRQLMIFGAAGQAASMAILAGTTSLIGNTKAGIVAATFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPSAALSTSANWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T5</accession>
    <name>A0A6A7C5T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_262661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5T5"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="356"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="706" mass="80283" checksum="1F74C9F95760EF1F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5W4</accession>
    <name>A0A6A7C5W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5W4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="12239" checksum="38AC30D74D7089FF" modified="2020-06-17" version="1">MSHHKQTPIYAPKLRHAHHLRSPPRNHSRSPSPAKGQQRRPLRLPGEVIGAITHHSFAQRDFVEIINLATDQQESGPGRYLMDKFKDYIRSIMGVTHIIGYGDLEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C694</accession>
    <name>A0A6A7C694_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C694"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="26915" checksum="0EE6CA4458A50F50" modified="2020-06-17" version="1">MSFHGRRQSPGSLDLSEIPPLSHPSPPSNTLLITNLNAPEIFTTSNLESIRAAINANAPLHSFSPLKSFRRIVCTFYTSADATRILQALDGETVLGNRTRVFFGAETNISPDEEQRYLKAPPAQKQFFISPPPSPPVGWEMRNEEPPNAMTHADDLVAALAKLNAQPSSPENPHHQEDEEGEVPRGRSVRRRRAGTGTLVYEPEDNQLPAIAVEDLSEGSPEGVITPAESIAPLHHTARPPVELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6J6</accession>
    <name>A0A6A7C6J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_275050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6J6"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="171"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="542" mass="60702" checksum="3F3969F1B225B3C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6M6</accession>
    <name>A0A6A7C6M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_262343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6M6"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="441" mass="48612" checksum="F49A053783B16162" modified="2020-06-17" version="1">MPFVRSLLSASRALSARGNVNPAISVWKAQGQLYNSARAYATVFQRDKPHVNIGTIGHVDHGKTTLTAAITKRQAEKGFASYLEYGAIDKAPEERKRGITISSAHIEYSTDKRHYSHVDCPGHADYIKNMITGAASMDGAIIVVAASDGQMPQTREHLLLARQVGVKRLVVFVNKVDAVDDKEMLELVEMEMRELLSSYQFEGDDTPIIMGSALCAINGKQPEIGEKKIDELLEAVDTWIPTPERDVEKPFLMSVEDVFSIPGRGTVASGRVERGVLKRDSEVELVGKGATPIKTKVTDIETFKKSCDESRAGDNSGLLLRGVKREDVLRGMVIAKPGTTSAHKKFLASMYVLTKEEGGRHTGFRDNYKPQLFIRTADESATLHWPPESEGAQEHKMVMPGDNVEMIVECHKPLALDQGQRFNIREGGRTVATGLITRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C705</accession>
    <name>A0A6A7C705_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_211083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C705"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="13791" checksum="83D85CA17F14E709" modified="2020-06-17" version="1" fragment="single">QKRYSEDHEWIDTTNSESARFGITNFAAKALGDVVYVELPTVGSEVSKGDTIAAVESVKSASDIMTPASGTILEVNEELDNNPALINSGAEGEGWIASIKTSSTAEWEDLMDAEAYRKYTEELDSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C788</accession>
    <name>A0A6A7C788_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_124572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C788"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15596" checksum="A510AA89C3790AD6" modified="2020-06-17" version="1">MTLVWGRPRCKKGRWTMELVALSQAARGANWKNSRECVAQRKDVPLRFGPEGALGLASAPGMELYYTWPAASIKLSIKYVRDPDSPQKQPSDCKRQTMFAIFDSIYPPSPLRNRDIRSLELDFMIKRPILAHVAHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C799</accession>
    <name>A0A6A7C799_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_226890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C799"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="468" mass="50383" checksum="74DC544C2F7509AE" modified="2020-06-17" version="1">MAPQTTQWTQPTPEIVAVVKNIVVFSGGSAANNLVDVFKSVRAAKRCTLSYVIPVSDNGGSTSELIRVFGGPGIGDIRSRLVRLIPEDTEEEVALKRFFNYRLPREYISAKDEWQDILESTHKLWDGVSSPKKELIRSFLTAVNGEMLKRIRPNSRFDFSGASIGNLFLTGARLFTGSFEAGIYLLSSICALPSTTAVLPGVNTNFALHIAAGLADGSTITGQNNISHPSEPTAAVPGAGLNTLNEDNEDDKAEDANGPGTLATLRKPALAVSKGTEEDLPARIERVWYINPYGQKIIVPGNPRVLDAIAASSCVVYSIGSLFTSIVPSLILKGVGDAIASPAVKTKVLILNASVDRETGPSTCPFSAKDFVQAIANACAESRGRERPRPEEFATYVTHVVYLDTKYSPKVDREALNGLGIEAMRLYGRKNDKGGMGYDVKALTQTLEVIMGVSTREGSFTRRNTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7B5</accession>
    <name>A0A6A7C7B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7B5"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25310" checksum="33C930E99F6D4B46" modified="2020-06-17" version="1">MALRCGGDRLGLKRNALMNELKPHFGPCLGFIWTIEYQKRGLLHVHTYLFLSRDVQFHDPAVDDDFIRAPARIPMEVSCRSSIRKYGTSVASVTANDHKVREAIDMGNEWAVPYNPQLILPLTSMIASLLTLFLTFTSPVARGFMRLYRTGPAVPTLKAFEEARAALLARARRGDNASQFIYPTVVEADTLGVPISARPGSDIAAAALDIAETWLGLVGYLNSQWRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M8</accession>
    <name>A0A6A7C7M8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_268274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15254" checksum="4DC058F39E83F157" modified="2020-06-17" version="1">MTTGSIIHWYKQTSFTDPVFEQRVTLNRGKFVRFHHDQIGKVERIFTYRDPGGDARIFLRVIDTVSHPCGQLDPITGCPIRQLVAMEARIIGLPASHSKRLYTIPIAMDDVSGAMEEQADSSDLLHVDWNIQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7P5</accession>
    <name>A0A6A7C7P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_143800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="MIP31509P"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="12"/>
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        <location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2863272.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="772" mass="86309" checksum="94085845E81B5673" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Thaumatin"/>
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    <dbReference type="InterPro" id="IPR032477">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863099.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7V1</accession>
    <name>A0A6A7C7V1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid aminotransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_254866</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="38885" checksum="82875988905F58E7" modified="2020-06-17" version="1">MGAKFPPPPTSQLDWGTIGFAVQKVNGHVEARYSTKTGGEWSDPTFVEDPYLRVHGLATGLNYGQQCFEGIKAFRAPGDGSIHIFRPRQNVERMAKSAAFVSMPPVPTKVFMKCLEMAVARNAVFVPPHDSKAALYIRPLLFGSSAHLGLSACEDYTFVVYVNPVGVYHGTEPVAALILEDIDRTAPEGSGAYKVGGNYAPIMRFSTAARADGYNITLHLDSKTRTEIDEFSTSAFIGVKQSSESGKPVLVVPDSKNTLMSITADSACAIACSWGWTVERRAVYYQELKTFDEVMAAGTAATLVPVKSITMKSRNEAVRYGHGGQAGPITIKLLTKLKAVQSGDEKDEWGWLHQVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7W5</accession>
    <name>A0A6A7C7W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_267957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7W5"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="378"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="549"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="700" mass="77557" checksum="785908789604C6BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C873</accession>
    <name>A0A6A7C873_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_201398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C873"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="97" mass="10198" checksum="F2A303A53620BB73" modified="2020-06-17" version="1" fragment="single">SHGRGGAGNISKEHASVEASDLKTPTIKAPTYTTGRGGTGNMAVNDPSHPEVARAAQDTEAPICHEKLAKGTYHWGRGGEGNMVTIGSADRREEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C891</accession>
    <name>A0A6A7C891_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_127004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C891"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="180" mass="20132" checksum="0076FE40C98C7582" modified="2020-06-17" version="1">MQSNQSGQRSSRHVQLPTTIASLLSMPLQPFDTQTCPWLCRPPLLHGGSSAHSPYSVCKNLGNERLKACRFSWYLLPIDFPCRAEEWLHVPSLQQFSSCTWLQMTITTSSNIPQPSGRLFDPPDVNTCIIRALSMAGALHSWRHRRIQVCVATVHCSCQTPAHRGGWTTSGQKPLFSEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C0</accession>
    <name>A0A6A7C8C0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_297893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="290" mass="30792" checksum="C4948F3DC92572C1" modified="2020-06-17" version="1">MTSIGTGYDLQNSVFSPDGRNFQVEYAAKAAENGGTAIGIRCKNGVVLALEKLVTSKLAKKGANKQISTVDRNIGAVSSGLLPDGRHLASRARDEAASWRSTYKAPIPVASLADRMGTYVQAHTRFNSVRPFGVTLLVGGWDAETDIDVDGAVGAGPSVGAGGRAKGAKHGGPYLYMIEPSGNCTGWLATATGKGRQAAKAELEKLQLDANEDDCITLEEGVKEAARIIHVAHEDNKDKEFELEMTWVSAVSGPTKGRHEPVPKTILDEAERLAKKALDGDDDEDGKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8X4</accession>
    <name>A0A6A7C8X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_255137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8X4"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="17654" checksum="4A5D90F0ACBACE13" modified="2020-06-17" version="1" fragment="single">MVHRWGTNGSGLIIYCLFVPAFALLSLLYLIPASTKEKFAGHRMIPLALDVLNTLLFLTAAIAFTVKLGAKSCKNSVSFGISVPADHADFKHRTIWRPTTSSWARASAAARLVPPTHSCGSPLLHSSSPRWAISSSAAAAKPSSAIPTRPSWHSPRSRCSRKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C939</accession>
    <name>A0A6A7C939_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C939"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="7792" checksum="5DDC08928AB9F6E4" modified="2020-06-17" version="1" fragment="single">MFAPVCAMTSLGGARSRSQLRGPPSDLIFRVCVAQRRRLPWGGCKGARQSRSTPCDSPTADVPCHNPPPQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9E3</accession>
    <name>A0A6A7C9E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_267652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9E3"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="41497" checksum="3F2F140831451F05" modified="2020-06-17" version="1">MVAAVSIQLDLEAPGGVPIRLGDSILKPDGARRYISLCYNHKPQLRPDSKGTVLREQTGSLLSIDEGGTSNVWRWTGEEVGGDEGGYVLTFQGEGKTRTAVLEKLDGRFVWNLQSTPQAGPDETQKQHAHITAADMRGASGPDADNPYDYRHYLQEEAAPAVKTQASPAIGALKPDSKPVEAPSRPAAAKTLPLDRKRKAPVSADESVKKKPKTTVTEKKTTEAKGAAKARPANGTRKAPSGGKPKSAEPRPTASGSAKATVEKKEFSAKEPTPQPKSRADTPTSVDAAGSDFGELILDNPTPEEERRPPLLNKSDGAANPAPLVLPKREEEVIDVDEEPADDDDGDVEELPAAAIAEPDSDGDDLGAQLAAALEEAQRAEEEEEISEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9J7</accession>
    <name>A0A6A7C9J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_192747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9J7"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="22234" checksum="55B2F71018F00564" modified="2020-06-17" version="1" fragment="single">IPPLSAPTFGLIQESLRSEPFWLLVACSLLNKTNSRSALPIFHTLKTTYPTPEDIISADEETIKEMLRPLGLFNKRAKTLKDLAGEWVEHPPQRGKRYKVKDYPDTGDHNGNAAHPNGTNTHPPSEENCKGALEIGHLPGCGRYAYDAWRIFCRDELRFSGGVVIGEPEWKRVNPQDKELRAYVKWLWAKEGVVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9L9</accession>
    <name>A0A6A7C9L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_267126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9L9"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="315" mass="34509" checksum="A673E5D348AE9FE8" modified="2020-06-17" version="1">MASVFATLNRLIGALDSEPFNNDEWGFQVLSSQTPLLDPYFDFLTTLNARRITDGSIPPFLAEISTTASRTGGVNLGVYSTKTHRTRDLYLPFDGDGKLNLTLQWCPLGVVEKSTWHVLDIAPNSPAEKAELLPYSDYIIGSPEGLLFGEASLANLVEGFLERECRFWVYNFEFDVVRLVRITPSRGWGGEGALGCMLGFGALHRIPTPLEEGPVQEEGEMLFDVNGRGGSVYEAGVGDAAQKQVEMVSAAQTQRQMAVTAQTKGGKKQSKATAGLDEYFKEGEEKSRQIDRPSSAKPADLPPPPKRKTKGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N1</accession>
    <name>A0A6A7C9N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_210176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9N1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="159" mass="17311" checksum="6CB998F23E1E4F3C" modified="2020-06-17" version="1">MSNKTLTFVRSVWDSFRATSGLEPRLLNNLQILTARPGNVTFSLPIEGHHTNRLKILHGGTIACMTDLGGSLAVASNELHATGVTTDLNVTYLSSGGKVGDTILAEAICDKIGKNLAFTEVRFKDEKTGELVARGSHTKFVRRAWEEKEKNNNNNKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9S6</accession>
    <name>A0A6A7C9S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_202464</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9S6"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="54"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2863972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="317" mass="35423" checksum="F144A729D65B3286" modified="2020-06-17" version="1" fragment="single">PPPSSSGGNGLLWGGVAAALLGGAGYYLYATNDPSTKTTGVFKPKWEDYQKVYDAVAKKLIDDDQYDDGSYGPVLLRLAWHASGTYDKETGTGGSNGATMRFPPEGDHGANAGLKAARDFLEPLKKQFPWISYSDLWILAGICAVQEMGGPDIPFRPGRQDRDIGFCTPDGRLPDASRDQKHLRDIFGRMGFNDQEIVALSGAHALGRCHTDRSGYDGPWTFSPITLTNDYYKLLLDEKWDWRKWNGPKQYEDKSTKSLMMLPTDVSLIKDKSFKSTVQRYAKDQDEFFKDFSNVLVKLFELGVPFGEDQTERKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA82</accession>
    <name>A0A6A7CA82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_103630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
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    </reference>
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            <dbReference type="EMBL" id="KAF2863518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19036" checksum="7B29D8FB4B29AD03" modified="2020-06-17" version="1">MEQLYDLFARSIDLKHVSLLFHLQQSHIKELAIPLIRRNNLRRLTVCSCACRRLLRYFADLDEKFSVAEAMKVQSSVEIVSATIKMPSPIFFDALATIRSVKELYLVVTNGSDCTVPLIDCHAFYSIAKLSNLTSLSLGKTIGFFPVKYSVSCRDWMQLFQRLPSLV</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864370.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2864556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 480.64</strain>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2863778.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBA2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="29474" checksum="6259AB4AF70F8AE3" modified="2020-06-17" version="1">MTPPLYSQPPLTILFILTNQPTMSEPKPFNPPLGPQPYTPALYLPTPTNLLITKTPTKNFLARTNNTTTPLLLTKRNPLTSRLKFFTPNTKKPLFALDPSPKKSQTTHTKYPFIITVDDSPSGRHSTVSFANASAESRSVQLLCRSNWDLSLTEVLLGERFVAKIVPSEKVNSREVMVEPMVDLSMIMAVVVVVAEWKVKKGGGILAGLEEEMLGRGGKESSRKGRKERELVVRSAKRSGNAGGIGTGMQLNALAHGDGRGDGGGHGDGGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBQ3</accession>
    <name>A0A6A7CBQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_208512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBQ3"/>
    <dbReference type="OrthoDB" id="4540844at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12453" checksum="86817F4988107052" modified="2020-06-17" version="1" fragment="single">SIVFSTSLNSLYEYKSGCREHKDCYGHLCSVNGATLPPHSMSLRSGSKATEYNKAARLVFDVDTKGYVSAIQRTNFTKHGTMRPTMSTPISGSGRLIATPQWQFGVSCVAISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBU5</accession>
    <name>A0A6A7CBU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_239323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBU5"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="426"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2864385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="703" mass="78301" checksum="5CEFA45A080E9771" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNY0</accession>
    <name>A0A6A7BNY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_224031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006072">
        <property type="protein sequence ID" value="KAF2857073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Velvet"/>
    </dbReference>
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        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
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        <property type="entry name" value="Velvet_dom_sf"/>
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        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
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    </dbReference>
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        <property type="entry name" value="VELVET"/>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5025637741" description="Velvet domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="154"/>
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            <begin position="1"/>
            <end position="148"/>
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    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17363" checksum="B2247D49D81AE3D6" modified="2020-06-17" version="1" fragment="single">MRVIYRIFTTASYFLFATLESVPPPDDAGPTRQTHESHPQRLTVLTGTPVAGIIHLDRPSPAGYFVFPDLSVRHEGYYRLKFSLFEGLKDMNSDTGPETQGETAHVTNRLEVHSTVFLVFSAKRFPGLTESTALSRLIAEQGCRVRIRRDARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP22</accession>
    <name>A0A6A7BP22_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_223893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CWC21"/>
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    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="12190" checksum="0F58D2A66C460981" modified="2020-06-17" version="1" fragment="single">DAEILKHERLRRIDVKVFELRAKLEDEGVSICSCYICCDHLRKKLQSNVSQTSTKETKGLKSHQGHEIARTKSEESERLPRAFGIPRDYGEGQHWRTQQRQDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQP6</accession>
    <name>A0A6A7BQP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_273569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006068">
        <property type="protein sequence ID" value="KAF2857095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="180" mass="20616" checksum="DCEC3BF080DD95B5" modified="2020-06-17" version="1">MLEKRVLQELRYVGLLSTGEVPHYELHEDDELSARLRTLQHELRNVSRINHVRKARVRELVEERMAMQEYNQVADDLDNQVIEAYVKRNRSQGKPAKKTTSLASRGVVQKGVATSSAVKEGMESIRTVVAKRKNWHEMLGPAVNYGRPDLPDEFTNIFDDESMKRLERAEAEAVAAETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR59</accession>
    <name>A0A6A7BR59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74010" checksum="7B6FEB2D3A5702D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR77</accession>
    <name>A0A6A7BR77_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
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    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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        <location>
            <position position="107"/>
        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="13119" checksum="D2562B7354D5E37F" modified="2020-06-17" version="1">MLLFCPNCSNTLSVTTNHAAGGNCFTCRTCPYQKPLDDGIYYERHYMPKKKRLDGDILGGADAWKNVDRTPIRCKNDRCGSNEAYFRQVQIRSADEPMTTFYKCCRCGTDWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRD8</accession>
    <name>A0A6A7BRD8_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025407368" evidence="6">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="420" mass="46704" checksum="49B5208A9B07C54C" modified="2020-06-17" version="1">MTLEISIIGSGMGGLALALSLSCQNFQNITVYESASNLGFVGAGIQLAPNLARILNTLGVWEDVEREAVDLRSTSIRLGRTDGELGFVELGDVRRVGCERKGVGFCFGERVTNVVSYGPRPRFRVEGREGVREVQCNVLIAADGVKSLVRDGMMRRAGKEVKVEETGQAAYRIMLRREDMEHDPELLELVDGESVTRWIGEKRHIIAYPVARHRIYNLSTVQPDRNFAAAPSEMYTTKGSKRQMMEVFADFCPKVRRMLDLVPNGEVCEWKLRVHEPLPFWTWDQTALLGDACHPTLPHLAQGAAQAVEDAAVLARVLAKLPNESPEAIAKGLRVYEAMRRDRAYALVELAAASGRALHLGEGAAKEERDRQFAALKQGKGPVPDKWADEDVQKMIYTDVVCKVDEEFESLYRNLSDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS37</accession>
    <name>A0A6A7BS37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_168824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS37"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="18463" checksum="AB7EF804610046B5" modified="2020-06-17" version="1">MEAPHAILFLDSMPLALAQPALIRFSRKARETVSARRLCWQRRSLFLPVHPNEATPGAELNVAQPAPPLSLPVGGRGGLLAGPFASATAGKEPRGLLPPKPGHPAEGSQGQKKNEKDDRQDVGPAGDVALKQSCGSFFVLVVGKHVMVKMKKPIRIPPLCVLCRTSTTYDASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSI0</accession>
    <name>A0A6A7BSI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zf-U1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_204428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSI0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="59" mass="6764" checksum="18878AA9918CF313" modified="2020-06-17" version="1" fragment="single">MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVTDYYQQIGQAKAQSIIDSITSSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSZ2</accession>
    <name>A0A6A7BSZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_195048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006034">
        <property type="protein sequence ID" value="KAF2857628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSZ2"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="57" mass="6388" checksum="2E967FEC780C4FE4" modified="2020-06-17" version="1" fragment="single">LNLLTPSFAELSDGLADLEANMMHLQLLNESVSRFNENFSAFLYGLNMSAFCVDFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT20</accession>
    <name>A0A6A7BT20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_251997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT20"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
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    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="467"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="605" mass="66406" checksum="188F9E3EFBD3B00B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT45</accession>
    <name>A0A6A7BT45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_251342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="545683at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="45629" checksum="BCBE29BB94F256ED" modified="2020-06-17" version="1">MGREPVIALVGKPSSGKSTTLNSLTDTTAKVGNFPFTTIEPNRAIGYLQIPCACSRPELASVTSSPLRKLCKPNHGACQDGVRSVPIELLDVAGLVPGAHEGKGLGNKFLDDLRHADALIHIVDVSGTTDAEGKATRGYDPSVDIAWLRDEIVRWILGNLMQKWGGIKRRHTAVKATAVETLRAQFSGYGANGAVVARTLDRLRLKEPLQDWSDQTVESVVNAFVDERFPTVLGLNKIDHPDSANNINKIAKAERPESIVLCSAIAEVFLRKLVKQSYIRYIPGSEFADTRKDLIDAGEPDGGGLKEPDEKLRNRIENVRDMVLFRFGSTGVNQVLTRASELLGLIPVFPVRNVHSFGSADAVFRDCLLVKNGATVADVCRKVMGDAPMAYAETVGGLRVAEDDPILPGKNDILSFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTB6</accession>
    <name>A0A6A7BTB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTB6"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="42218" checksum="8D45EDC28E96C816" modified="2020-06-17" version="1">MTTPVKATFTQRACISFWLFGLINNLFYVIILSAALDLVGPSIPKGTVLLASIIPSLATKSLVPYVIHVAPYGFRILVLALLSVGGMLMVTMASPKAVAVGIVLANLSAGAGEVHFLSLTHFYGPLSLAAWGSGTGAAGLVGAGAYALATNVLHMRVRTILLLSTLAPVVMVLIYFSTLPLEPLAREGGGHAAEREGLLAQTSESQSLGAKLRSARALIWPYMLPLFLVYVAEYTINQGVTPTLLFPLEDTPFKHYRAFYPTYGAIYQLGVFISRSSLPFVRVRTLYAPSLLQVGNLGLLIMQSLYMFIPNLWIVFLIIFWEGLLGGLVYVSTFAAIREEMPAKDREFSLGVTSVGDSLGITVAGFLSVVVEKTLCLWQVRHGIDWCTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF2</accession>
    <name>A0A6A7BTF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_222262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF2"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="35483" checksum="B7DB5C5658A18061" modified="2020-06-17" version="1">MVAHAAVTLSPAELAYIHDSLAQQPPIRPDGRSPTQFRPLVAETDILPSANGSARVCFGDGTEAVVGVKAEVEREAEFPFAGPQPVGEDEWLEVAVNMPGQRDNDALSVFLGSMLTEALRADGKLVERLRINARFHWRLYVDILLLSAPSSYPLPLLSLTTHLALMATRIPALVSEGEEDALFNDDWEAATPLYPRPPKRHSKHASYRRPPVTLLVMSVGDNLFFDPSQEELAVADAVFAVSVMRESNNDKLRVVALRSVDPPSRSTTAGVSLATGQAAEAKQAGDGASWRPPPRGGIGRNLMLSLIEAVTEANGVGEEVLQGLADARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF8</accession>
    <name>A0A6A7BTF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_259720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF8"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="30273" checksum="4EAD9612455FA035" modified="2020-06-17" version="1">MHTVLITGCTPGGIGHALAREFHARGLQVFATARQTSKISDLAALGISTFELEVTDAQSISTLRDAITAETGGSLDMLINNAGRNYTVPALDVSMSEIRSVFETNLFSVMMMCQAFAPLLIRSGGTIVQIGSVAGVTPYVFGSVYNASKAALHSYSDALRVELAPLGVRVVTVITGGVISNIARTHISLPPNSYYLPLEKEYELRQTHSQANGIPNEEYAKFVVQKVLGSKQNVLWAGGKSWLAWFGTYFLPKWVVDAYMTRMCSLWKLKQANMKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTN1</accession>
    <name>A0A6A7BTN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_221118</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32574" checksum="C217ED0204489ABA" modified="2020-06-17" version="1">MPFVLAHGWRWPKAFTGLLVFELLLIVGCLVLFGLADNNAYRTKLWQNGFDEGFNSAPDQIIYEYANHRKAHTPLIWSSKLVQYNIVISVLSLFILLVKSCAFAVKCWFPVISALVSAAELALYAVSIHNETSHDMSDKQHPNPGLPWYLSKGCKYATKGNHSYCVQAQSAFALTCLMVALFSIYLIFSILNIRATPEEAEKRKTSREFDLEMKKIHASYHAEKDMSKEERREMNRQLFLNLPKTPATPAFGAPTPRTAAFTQLNGGAPPPRGAASGPRGGLRFREQYGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU1</accession>
    <name>A0A6A7BTU1_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5385072at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="37"/>
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        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="32339" checksum="60937B4432FE0C4D" modified="2020-06-17" version="1">MSTAAMNLSGRSPHQKPGPAHYPDATAMSSTGSYAKRSLSNATSTTTSSTSAAPPRRSTSSRSTASQSPTSYVALMRKQKASVWCDRAQHEDPRMLAAQRAAKQRAAMEVAGGQHRTNTARTATSGSGMVDGVRSKIRHHGAPKASTYTGSNLMGGGGGVPMRLSASEVDDAGSDEDTTHKYHSRASSGRSSLASAIHHQQQYQQQPQSYARRTCSSDSTPASHSPSMSPGSPAGARTPMPNHYTSESQDYVSHLPSQPVPRMTEIEQQRQFSEELKRRGSVDDRAMTMSAGRLFVANPDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTW6</accession>
    <name>A0A6A7BTW6_9PEZI</name>
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        <lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="PANTHER" id="PTHR24345">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858624.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="524" mass="58586" checksum="22B43BC4DB042FC2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTX7</accession>
    <name>A0A6A7BTX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L28e</fullName>
        </submittedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="155" mass="17212" checksum="C793EC3DDA07E501" modified="2020-06-17" version="1">MSSNISADLIWEVTRPYNAFLCKRKQSGGVQFSRDPMNLTNVHNRKYAGYCNTEAIGINAKGDKLEVKTKLPKKANYPAKMYHTTTFSSSTPSRKIYKSVVNGTTRKGYRSDLRAEAVARASAVKRSQREVKAKSHPVKLRGKKAKQAKEAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTY9</accession>
    <name>A0A6A7BTY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTY9"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="20959" checksum="EF81E99AC2823D2D" modified="2020-06-17" version="1">MVRYAATDIEPGKSARARGSYLRVSFKNTRETAQAINGWKLARAVTFLENVKEHREAVPMRRYAGSTGRTAQGKQFGVSKARWPVKSAEFLLSLLKNAEANADTKGLDTSKLVVTHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEGSEVIQKGPQVVRREDQHLSSRQRARAVHGAITQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU17</accession>
    <name>A0A6A7BU17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU17"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14129" checksum="1F1355770BA6615B" modified="2020-06-17" version="1">MAGLKTIIILSFVLAIGILLVILSSALWQNYLPLLVVGVYIVAPIPNWICSRAGQRFDILDAEQGNYEDLGRFLTAFFVVMGIALPLVLFHTDQIRTEAMIMSIIGGLLIYSTIVAFGLFFSREEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUM2</accession>
    <name>A0A6A7BUM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_221698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUM2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="192"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="486" mass="54946" checksum="F338D8F4A7055B56" modified="2020-06-17" version="1">MDRSFDLLAYKPSLWQSIRAPCQGTEIAATPNGPELQELATALAWQTKLISRHPYNPQNWIMRAKTLEKLQYPELVVGDAHKAVLLCGYLATQARHSSQWRLGYGMDFWMSDDQTSSDDETEKIQSHILHIRHQAEELWSNHLPRGPHLASEGLYFQRKYPWMEPRHGGRDEGLISAINEEFQTKAPKGKTPCCVLRRDAVGDAGSEAIGVFATRGITAKSTILMDKTQVWGCTGPGVGKSPRKIEYGCANPMHPNITGEDTPNLGWIRDELGGDAAEAIMRCRLLFYCLRDGVSHPLDHPLVARLTPNYYQLQPGRFQADYDIELPVSWLQRCGMDIFAAITKQNYDTWVLFTLWARISNNSWSDPIHTGLQPLFSFFNHSCEPNASWSVVPHDHTTLHVVAARDISAGDQIFIHYAGYNSDDMCQVRRKTLRRWFGGDCLCTRCVREEKEARLEDPKTPTTTSSSWDLGPKPVFPEDLVGSSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUR1</accession>
    <name>A0A6A7BUR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF292-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUR1"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32734" checksum="99641FF2FB9F0E23" modified="2020-06-17" version="1">MPNPQVLIPKLRIQLKLSISRLRLLQSKLTALSKSDRRDLATLLESGKVSSARIRVEKVIASDVYIEALEMLELYCELLLARMGVFELELNQSKSAPQTSNSKLGQAASNSKTASKSGQTSSASTQKPSNPGSGSTPISGSNQVSTSSNLGSPESHSPSPPSNEETPLDESALYESISTIIYASPRVECKELLLARNILAELWGKERTKAASEGVGVSEKLLRKLKVETPTRELVEGYLNAIGGAYGVQGYGDHGGKDIEGEGPVEVSVPQLKTDDVESKIKEDKLGRIPDADELAARFAMLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUT3</accession>
    <name>A0A6A7BUT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_220076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUT3"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="44802" checksum="54A908E6A6F51752" modified="2020-06-17" version="1">MTGRASNKADLTSGSRPSSVRNSEDKLRSGPTTVRANETTAGAPVQTDSGEGNAKGGGWWGSMFSAASAAVKQAETLAKDIRGNEEAQRWAEQMKGNLSSLQHLGKDLQSRAIPTFTSLLSHIAPPISAHERLQIHITHDIQNYPPLDPLVYSAFSRVMAQVEGGDLMVIQRGSENRSKDDELQGYRGGMLGGASGWTDGPWWREEHAKRQLGTVPGLKEGSRLARVSAESYAKEFLEARGGIEEAAKKATETLSKSNPTRSSDIFLAVQAVSYTADKSLFAGDGRQKAEAAPSGVVEPEETAEDVVAFAIYLHDPIHSICFSTISQSLPQKWVDWIDARPSEGENLPESIQEIINSGGVDPREWVAEWLEGSLSIAIGVVAQKYVARRMGVGEGGLGHGKKRVEEEGVGGEAARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVG6</accession>
    <name>A0A6A7BVG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin, gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVG6"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="375" mass="41623" checksum="0520F989D2EE6D5A" modified="2020-06-17" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSALEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVY7</accession>
    <name>A0A6A7BVY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_265364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVY7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="26084" checksum="9F0CAF65C968A854" modified="2020-06-17" version="1">MIVALGEMMACMPRRETPTSYVARFIHPLLGGCHELDLLSPVGTNLWRWNGRPTFYRVGQKFGLSVLVFFRVLLIFNFLPTRSYGMAELGFATIKGLTLNGFLVHAICVFADAVNHRIVAWPDDENHLREEIFSTFHTRVRPGAFAPLLVDNNDALGKFVGFCAVSGVAGFSYQGTKLVIIALGKAHEGPSTAIPSVIKQNHLSGPVHPRWSSFLRPHGFERLPILGCCLHGQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW31</accession>
    <name>A0A6A7BW31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW31"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="22082" checksum="9A62928F3FEC7FCC" modified="2020-06-17" version="1">MSIQANPSTPPPATMLSTPFKNLEKYLTTPLPIQSTKKKRRRSPLHTCRIYLNHNISPLYHAVISKQRRFVKDEAGNQEPAKFHRAVEKLKIILAGLHTLRRVYLHQVKARQGITESEKFRAGDCEKRDLQLVDSVLGDSWNVSWVVYFLKNACDLVLVEGKIAFPMVEYWLDAAIEEGKRVKLAIKRLMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW41</accession>
    <name>A0A6A7BW41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_200922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW41"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="16574" checksum="E7DA994EFEB040F0" modified="2020-06-17" version="1" fragment="single">MFSLPILPPPGDPATALRFPQARPDSPPPFSASTAAPQLTHANRLAQQRRDEERKALVAKSAAAQLAAEEDAVEQRKVAIQTFGAAWIRPPGISKTLQAMNEEEAERLEAEELARQEQNMADLQARQQQEEARAAGQAAAEEATTEHNLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWA3</accession>
    <name>A0A6A7BWA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_282633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWA3"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="40329" checksum="424082E9CD08AA3B" modified="2020-06-17" version="1">MSTIPHLSTLGAGSRRRTRLRGQGGRNEGDVIDPDSIIQQTDCDASNSRISAVALGYLDDKFAKEFSAPGDEPQRRYPIINRGTYVRTTAIDQLAKSFLRTTHDGQRKQIISLGAGSDTRFWRLWKESNHQEQVDYYEFDFEPNVSRKRSAIQQSSVLSSVLVKAREGGWNYHLHALDLRQLAGDEPPNLPDISINAPTLLLSECCLCYVDPDSAMGVLKYFTTTLQGPCSLILYEPIRPFDAFGKTMVSNLGSRKIHLQTLKRYGTLEAQRQRLRLSGFIDGQGARDVLHMYQDDAWVSPDERARLEKLEWLDEVEEWKLLASHYCVAWGWRGEVFGRAWEALEGGRTDDERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWD6</accession>
    <name>A0A6A7BWD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_220514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWD6"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="329"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="428" mass="47672" checksum="7404915D3E92A92D" modified="2020-06-17" version="1">MRQLERQTRQKEASPPRKPKEPTPDLDGVVSILERKRRMTQWDIKPPGYENVTAEQAKLSGMFPLPGAPRQQPVDASRLQAFMNQPGNQATKSALKPSTARQSKRLFVYNISASATAEKLQEFFNSLLNGLNVTKQNDPCISVQVSEDHSYALLEFRSAEDATNIVALNPTIMETKGTQDPRLNGAHGMQIRRPKDYIMPTVTDESENDTGSLSDMVPDTQYKMVITNIPEFIQHEQVRELLTSFGELKNFVLVQDMNGNSRGIAFCEYSDAKNCTDMAIEALNGLELTDRKISVKRASIGIQQVGGEVSVNAMSVMASSSNDDQLVGRVLCLMNMITPEELMDADEADEILEDVREECAKYGEVVDVKMPRPTSGNRQGNGIGKIYIKYEHPEAAQKALAALAGRKFSDRTVVATHFSEEYFDINAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWU9</accession>
    <name>A0A6A7BWU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWU9"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="458" mass="49519" checksum="7A54AB26BF608B54" modified="2020-06-17" version="1">MDLTPTPSPARRALQVTLAVIYCLLSAGTVFGFAALKPVFVSEGIYHELCTPDEVRKGVWVCHAQDLRLNLMFTVAAVSTNICALPVGSVLDRFGPRISSCIGAALLALGALCLATADKAPVDGVLLGFWLLALGGPFVFIASFQLSNTFPDRTGLILALLTGAFDASSSVFLVYRLVYQHTDGGFTPSRFFLVYLAVPAFILIAQLTVMPKKSYKLVAERGGGMAAKPAALKGRTAVQQILTPWFALITLFTVVQMMRINYFVATIRMQYTYMLASPEQAARLNGFFDVALPLGGVFSIPLIGLVLDRTSMPFILGLMTTLATLIGGLGIIPQVWASYANITLFVVFRPFFYTVVSDYAAKVFGFKTFGTVYGLIIAIAGICNLGQAGLDKVTHEVFRNNPLPVNVALMVVGFTIGTALTLYSWRTRNEAARELLEEEAEEARETLIPSEGRGYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWW6</accession>
    <name>A0A6A7BWW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_282627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWW6"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="9">
        <location>
            <begin position="180"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="44928" checksum="8B8FC3E63F0AA2AA" modified="2020-06-17" version="1">MAEEIVGSVDMDTGNDEIMLAATNHDIEALTALFKTHGANFKDPDTGFSPLHAAIAACEPDDDVPVNGEGDALHGQALSEDSALATIKLLLENGAIWNELDHNDETPGCLALRLGLKSVYSAIVDAGVRAELLFGRLDKFQLLADDESDDDDIVGFEPAPASMATVRPPGASNGPKPVLSNPNVNNEDYLKSELTYSGDRLLDSDKNAVMMDWETEIMKTSADQLCPKPGLRTMNVGHGMGIVDSMFLENKPEMHHIIEAHPAVIKRLKDTGWYDKPNVTIHEGRWQDVLPKLIKQGVVLDGIYYDTYAEDYKDLKEFFQEYVITLLDQKGRFGFYNGLGADRQVCYDVYTKVVEIDLYDAGLDVEWTDIKVPDLKGRDEWNGVRYPYWGTIDTYRLPTCKFVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX80</accession>
    <name>A0A6A7BX80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX80"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025666701" evidence="1">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="160" mass="17576" checksum="C5DBE4F437997AD1" modified="2020-06-17" version="1">MKPTVLLPLFLPLISGYITINPLQIELHSGKYNLNFTQTNSEGYPDGPSKQPDQCNLSWLSFTQPATCYKSCEGGTRARITPGTFKGLDDFSLDVWQDYHGIGSWLDVHGTARVSTKDLLAGYTCKGNVCEVKKGGRGFRTEEGVVGRDEGPMPDIPICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXB3</accession>
    <name>A0A6A7BXB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
            <ecNumber evidence="7">4.1.3.27</ecNumber>
            <ecNumber evidence="9">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_258560</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EC" id="4.1.3.27" evidence="7"/>
    <dbReference type="EC" id="5.3.1.24" evidence="9"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXB3"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="20">
        <location>
            <begin position="144"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2859712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="419" mass="46194" checksum="00075994E25DE625" modified="2020-06-17" version="1">MGEQCIYSLFGGVVDQTGEILHGKTSTLCHDGKGIYRGLPQDFAVTRYHSLAGTHPTLPECLEVSSWVPSDVSNGKGVIMGVRHKKLLIEGVQFHPESILTAHGRQMVRNFLHMQGGTWQENDSHAVTSGVAATNGDANETSILEQIYAHRRKAVAVQKSTPSQTWDDIQGAYKLQLAPTVIDFAARIRDSPYKISLMAEIKRASPSKGVISMTVSAPKQAHEYAMAGASVISVLTESEWFKGNLDDLRYTRKVLDKATDRPAVLRKDFIFEEYQILEARLAGADSVLLIVKMLDSETLKRLYDYSQSLRMEPLVEVNNEEEMKAAIALGAKVIGVNNRNLTTFQVDMKTTTRLLDLIKGQEDVVLCALSGIATPQDVIDYRQCGVGAVLVGEALMRAEKPVKFIRELLGGPDCQSWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXI2</accession>
    <name>A0A6A7BXI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_271591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="13">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="1235"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2859419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1536" mass="173149" checksum="42168C1F75FC53B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXI9</accession>
    <name>A0A6A7BXI9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_258450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
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        <property type="protein sequence ID" value="KAF2859924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="542" mass="61887" checksum="F524C9DE81AB0B54" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY01</accession>
    <name>A0A6A7BY01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_249091</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="MU005991">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
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            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140780" checksum="84F75F5F751DF48E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY50</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_264633</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY50"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12993" checksum="8F586B9E0CE6F0FB" modified="2020-06-17" version="1">MSFSEILVIWSVICPSNGGRSTYLAFATHFCNWTSAFRQKSGAPRLVGLFMDFHRFTDVKLHQIGLNNTVNVPKWQPRQPSPRLWYETGSPDESQPAPFVQVTRPAQQHCRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY58</accession>
    <name>A0A6A7BY58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_204911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY58"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="451" mass="49990" checksum="11F969F632AD6E15" modified="2020-06-17" version="1" fragment="single">FNKLTITLLERATENKQSIAEVANMESVVPALVMLWLKASAIGVSVKASQTLLDLLRADQNPPGAMWNRIFNDRNVYNLFFRICAPKTLGNTFAQSRLLAWLPDIAHMNWTTVVSSHCPEVESEYGIKGGGLLDFASLHMIDDQDELMQVNLVEYYIRLLKSNQAALSYLQGNGSHDRILNKYYQGVQWTFLLGPIVEYITTYITLYPNHTDCLKTANTLNKTLCEEFRRANFIHNDQTPYHISILSSLPRKALMRKPWSSSSLSLLTTQVTTPKVLYALAEIFSGDAASPGESSAARALYYKNLSMSPNMWKDIVAHARSVALVDLALAAIAFITAIINAPWPSSAKSPPEDYSARMSPPHGIATPETGTQAILAPPALEFVLPFLLEDDVSFLKLGVMGDERNSAQRVADAKRRALESLATGVQALIQSNDHDTKPYEMILGTITQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS1</accession>
    <name>A0A6A7BYS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_218427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS1"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="26291" checksum="270A5CABF939B1E4" modified="2020-06-17" version="1">MPSLLRPRSSGSTTTRPRTEVVINIYDLLPPGRLSSILWTVGSSLLHSGVVVKDREYAFGGHSKRDTTGVYYTCPRFEPPGGTFRCSLSQGFTDRSDEAIDKIVREVSEEFLGPRYNLLTNNCNHFTSVLSERLTGRAAPSWLNRAASIGIVLPCFVPKEWISPPDFETVDGELVDECAGDECVDGDATENMAMLNHQRRTSNCRAAQPARLVGLKDSGRRDLPAAERAPLPRHARSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYW9</accession>
    <name>A0A6A7BYW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
            <ecNumber evidence="3">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_232583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYW9"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="35668" checksum="B0E83548C1AB3327" modified="2020-06-17" version="1">MPSSLDQLKAAGTTVVCDSGDFATIAKYKPQDATTNPSLILAASKKSEYAKLIDDAITYGKQHGKSIDEQVDSALDNLLVQFGSEILKIVPGRVSTEVDARFSFDEKASIEKALHIIDLYKEKGISKDRVLIKLASTWEGIKAAAKLQKEHGINCNLTLMFSLPQAIAAAEAGAFLISPFVGRILDWYKANQKKEYSKEDDPGVKSVKEIFNYYKKFGYKTIVMGASFRNIGEITELAGCDYLTISPNLLEELYGSQDAVPQKLKAAEASSLNIEKKSYINDEALFRFDFNEDPMAVHKLSEGISKFAADAITLKGILKQKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BYX0_9PEZI</name>
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            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="170" mass="20235" checksum="7D7D9FCBE263B9B5" modified="2020-06-17" version="1">MSLDAQTSDEDLVHKHFATEAVVERTQGYAKRKEREFLSEEMEEGSRNIKQRTPRFFRCHLKRKLKHADIPTEVSILRNILFDIVDGKMLELAHQKPQQRKYPCVSWKGVVNMRYITRIISNRRSALDFTRQLVFRRDFNRRSALDFTRQLVFRRDLYAGTHLLTIIIKG</sequence>
</entry>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="250" mass="28124" checksum="C32ABC92B8CE20FF" modified="2020-06-17" version="1">MAWHPIKQVYDQFKLALHELQAIHAQGESRKTLCTNRFRTQWDLPWRHEIMGILEEAARNNQEAALSMDSIGRHWHQDADMMPQSEADRGIRAENDSHALPGWRRGPRGVAPMPTKHSAGTSMRREFSLDEEGAELLAQVNRDATTKGSRVAPARLQAPSSRGITGDRIDRRNGSTRARGSGRRRGRVGSGATRGRVRAADPSVLGQVCERLEAIEQKQQKMLRAQPPQPAFFQQGPPQQWQQMPQPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ52</accession>
    <name>A0A6A7BZ52_9PEZI</name>
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            <fullName evidence="2">DUF1264-domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ52"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="23862" checksum="7E42281BBA8C4D92" modified="2020-06-17" version="1">MSQESSSKQIFAPPQRLCAHLNAFHTYASEPGVRSVEANHYCAHLNDDVRQCILYDSDKPNARLIGVEYMIKPHLFEKLDDEEKKLWHSHVFEVKSGMLFLPKPEGVSKEEWEKEELKEMEQVVTLYGKVYHLWQVDRGDELPLGPAMLMTSFTEPGQFKDWDGAVGGRDRRFGIDSAKKAELRKGIKEPEIVKGADWAWEKNKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZH1</accession>
    <name>A0A6A7BZH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_70095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZH1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="566" mass="64124" checksum="E254F441446F3CF6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZK9</accession>
    <name>A0A6A7BZK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase regulation protein NCA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_218171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZK9"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="635" mass="71664" checksum="45E3A5D38AB1699A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZQ8</accession>
    <name>A0A6A7BZQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_277136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZQ8"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="11">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1M6"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13262" checksum="E42A24B1C03E18B9" modified="2020-06-17" version="1">MSHLVPLNELHSVQPGTKVRFLACVHGYNGTNGTLMLCTRFPTKSRTPAAIVGVTNVLETLNHELVTVGAWLNIMGHVGTKQKVPYVEATMVWPAGVVNLDRYHAAVEGFHKLSNDSDSTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1V6</accession>
    <name>A0A6A7C1V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_269887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1V6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18293" checksum="531D7971DBB4E01D" modified="2020-06-17" version="1">MSQVSNPCYTIAEVANAAHRFDPKTLSQGYELYRAGDLSVEGVYAPPEEALIVLEHSEFSGHYAMSKAAYSREKGLNRTCNPEGAIIRHDLAEILSSVQAPPAAQTGLNIPMTDTDVQYIQQRLKQTKYGPFTATQRFLDQLEKSKQHHGIHYRIDRGTDGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C216</accession>
    <name>A0A6A7C216_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C216"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="503" mass="52982" checksum="541740A89BAF7175" modified="2020-06-17" version="1">MSYPTSFTMDAMAEPGTPVTVHKEIKSQATLLGSPTWGFDGAFSDGQASASSPKHASTGADDGTAAKIAQADKDLVTNVENAMKSPTQPLPANLCLPASMPVGPYLLSAFQNHVSNRNTSKVVEKGSATTDKNGPAETHTCVPTEGEHVFVGVRTGANAHNTYAPDDTKGHEHTAIKGNDEIESGKTYDEVEASEQCIESLQADDVLVTHQLDANNVDGGVDEGTDGLKATQNENGDNYMTMDVGMGSSRQDAGNNGVPDEGKSPKNSSHDTTSKDTGLKDNTSTGTTLKKTTINAAAIEDAKTLDDKGTGHGETSIGCTGIVSSNKEPANSIKVQSSNPKHDCQETLPNAIGHAVSGGYPINMETVTTKLSDVRVSSDGAENDPASAKKSGKTGDIDGISNKRKSQRSDLSPGGQPARKKRKSNANALLLAEARFFTTGVWEDPGHQSHQRLRSHEIVALPQRARTPLTRHDATTQALRIPVRQRGIIGRGRGSARGRGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C248</accession>
    <name>A0A6A7C248_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C248"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="468" mass="51563" checksum="C8D3FBCAA7D8F5A5" modified="2020-06-17" version="1">MSREMSSSTIRQRSQDESPILSLLSVEEDAPRRSSFLKIMTTLCNIVKWVPPTARFDSEHPTRFSWYLALLFCFLSAAMNASLFWTVSVLKYVASAAAVPMAGDVPSFSLGAYASSLVLLCPIADQYRRRLVLLILILSGAIFALCLATTTSSEAYQAFLFLTGIPVIACQVLMAVIGEVVPVRERPARVAMVVSATQVGAIYTRVISLVLPRYSSWRYVYWVATSVQFAALLLTWAFMPDYPSNSTGLPPHKQLWSVWKLLGKNPRVLQASVLAFCVGAVFPSQWGLLRGAVFSGDGSNDWEHYSLVGAACLPIVITPLYAGTIGKYVTSIVTVCVGIALCFTGLTFSNFSKPQLLGPILQVFFAELGRELMQVGIRLSMFSGATQFQNGMEAIYVFWGVIGTMTANFFRIPAVTDWTSISTSTWRGKIPTLLFLMSALVVALARGPRERRWVGWCGGMQWRGTSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C255</accession>
    <name>A0A6A7C255_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
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        <property type="protein sequence ID" value="KAF2861015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CDC5L/Cef1"/>
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        <property type="entry name" value="Cdc5p/Cef1_C"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SANT_CDC5L_II"/>
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    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
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        <location>
            <begin position="1"/>
            <end position="56"/>
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            <end position="52"/>
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    <feature type="domain" description="Myb-like" evidence="11">
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            <end position="102"/>
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    <feature type="domain" description="HTH myb-type" evidence="12">
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            <end position="106"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
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    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="681"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861015.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="81304" checksum="E5E354B426FD26D8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2H6</accession>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_229741</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 480.64</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="129"/>
        </location>
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="36787" checksum="5D9E548087755BFC" modified="2020-06-17" version="1" fragment="single">MNAASQGSACKAKNGIRLFHSTTAKFGRRRPAFPSVKMAELEAQAAENARVDRLSQHLKPYTEEEKKALSQRYTPAQMEAIEAGEKAVSARDMIAQGRLRGDAFRPTYIDDFATRRPVVDWPDPNEKPRPQKGRGQLLPNVEYGSEADSYQRLSQMTGMSLDEIKNIRVKNVVCHRVANQTHMGKIRQMYFLSIAGNQNGMVGIGEGKAQEMTDGHRQATINAIRNMRPVARYESRTVYGQPEAKVSGTVVQLFARPPGFGIRCQPLIFELARAAGITDLAARTPRSRNKMNVVKAALKALTDQRLPEDVARSRGRKMVDVRRVYYAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C2I8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2I8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14310" checksum="4D450BCB71E169AD" modified="2020-06-17" version="1">MVHRNGPVKRSLSSARTLQRHVSKLRQLPWLPYFLPFFLFTTRNAASLSMADGSLLGLLLATSFHPLAAGAFEIADVSTRPLSASFLRRRYSWTKCLESIVDDAWCTVSVKPSASVPSIASASTTESASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2J5</accession>
    <name>A0A6A7C2J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na/H antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2J5"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="25"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="474" mass="52843" checksum="C9452703FDE4A185" modified="2020-06-17" version="1">MPTLTLTNFNIVCAVLGGFITIFGLISYLLKEHFYLSEALISTLAGIIFSPHATNWIRPSQLVGRDSDPETLEQVTLYFSRLVLGVQLVLAGVQLPSKYLYKEWRSLSLLLGPGMCAMWMITSLLVWGLTPHCGILQALAVGACVTPTDPVLSNSIVKGKFADKNIPVRLQRVIIAESGANDGLGYPFLFLALYLIRGRGMGIWFYETWAYVILMSVAYGAVVGWLAKELLHWAEERKFVDRESFLVFAITLALFITGTCGLLSTDDVLACFIAGNVFTWDDWFRLETEDDSFQPTIDMLLNVAVFMWIGATCPWHKFAHNEVIGIGRLIGLGICVLLLRRLPVILTLKRWIDQIGSWKEACYMGFFGPVGISAVFYLFVAREFLREEKPHKHSEDTLAEMLEVEVWFLIICSIFVHGLAVPLTKLGVALPRTLSRAVGENSSTSVDERRGVEGLRGEELRNAISAPVPARVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q8</accession>
    <name>A0A6A7C2Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_257335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q8"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="91"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="515" mass="57405" checksum="BD46C354B1665F41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W8</accession>
    <name>A0A6A7C2W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_256655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W8"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="284"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="924"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115691" checksum="0835DE0DEC7176A5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Z9</accession>
    <name>A0A6A7C2Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_256426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Z9"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="58655" checksum="8225074AB812D853" modified="2020-06-17" version="1">MADNTSPHDKNSNAGTVELKDDTVVIVLGASGDLAKKKTFPALFGLFCNSFLPKGIKIFGYARTKMDREEYLKRVKSHIKTPTKESEEQLEKFCECTHYISGQYDQDEGFDELENKLEEAEKGQKRNNRVFYMALPPSVFIPVSEKLKKWNYPKNGIARIIIEKPFGKDLESSRALDRALRPNWKEEEIFRIDHYLGKEMVKNILILRFGNTFLGATWNRQNIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLTMERPISFSAEDIRDEKVRVLRAIPSIERTNVIIGQYEKSVDGSKPGYKDDDSVPKDSRCPTFASMVAYIKNERWDGVPFILKAGKALNEQKTEIRIQFKDVMSGIFKDIPRNELVIRVQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDALKGDHSNFVRDDELDASWRIFTPLLHYLDEHKDITPMGYPYGSRGPAMLDDFMASYGYKFSDAATYQWPQTSAKGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C350</accession>
    <name>A0A6A7C350_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_204517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C350"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17993" checksum="38E60391AC9196F3" modified="2020-06-17" version="1" fragment="single">SEIRLPRAIQATYLDPLRRRPEGYHTLPVTCDLQIRSYSVRNLEVYSDFAMRAAYYLNLVAIGPLPLPKLRTLTTVIRGPFVHKKSQENFERITRRRRIEIRGGHPDAVAAWLAFVKKHRYYGIGMKANVFEYSGLDVGKDMDAESVRISERLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3M2</accession>
    <name>A0A6A7C3M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_284898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3M2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="13338" checksum="98EEE93115ACD9B0" modified="2020-06-17" version="1">MLHSLARAIFKAFGSLLGATNGFHALLGSTLALGRRSRLCLWRSISILLSSDLHSRSLGSLLLLLIRCQFLGLFVRGALCTMFLLAIDLLLLSVNLILNPLPVSAHVRDSLSVQVGEKSEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Z0</accession>
    <name>A0A6A7C3Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_243924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Z0"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="47708" checksum="3168AC0849CC593E" modified="2020-06-17" version="1">MAQDQTVRRKDAAKKQSKGQLAKSEEEYKEILSKPPGANDRSVREWEEALMDLGQLYLDGKRVEDLTTLIQQTREMLPSFARAKAAKLIRQLLDLFSEIPESLDAQIKVTQSCIDWAVAQRQGFLRQNLEVRLVGLYMQKQSYYDALTLINRLLKELKRLDDKLVLVEVQLLESRVYHALGNMAKGRAALTSARTSAASVYCPPLLQAGLDMQSGQLHAEDGDFNTAYSYFIEAMEGYHSQDETEKATSALQYMLLCKIMVNSKDEVDQLLASKHAVRYAGPNLDAMKAVAQAHAHRSLDEYEGALHAYRQELGRDRFVASHLQHLYDSMLEQNLIKVIEPFSRVEISHVASIVGLDAPQVERKLSQMILDRVIVGVLDQGAGVLVIYDESERDRGYDAALDTIEKLNNVVDVLYQTQASMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C456</accession>
    <name>A0A6A7C456_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_281090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C456"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="212" mass="23327" checksum="2E865F5D060BE952" modified="2020-06-17" version="1">MTANERPKTSGPASGPESPFPIRLSGKVVNGFGRGSKELGVPTANIPLSGLSVGGHENIQSGVFFGWAGLTPCQATKQSPPESVGKYQLMSADVSKALYKAIQDEKGTGQSSGAVYPMVMSIGWNPFYKNEVRSVEVHIMHDFETDFYGEHMNLCILAFIRPELDYVSKEKLIEDIRTDIDVAGRSLARSAYLRFRKDEYLVEFRDKADVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C482</accession>
    <name>A0A6A7C482_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C482"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="141" mass="15760" checksum="E5D5235D11FFBB8D" modified="2020-06-17" version="1">MSGSESLLVPYQEAFHHLASLSVRVTTPHPPPEERVAAGFWPHTQPSEEEYSDSNDDPDDGEEKMDAKSKSYEVSAEGGQTFAGQGRNLPAFLMHNRIKEFLDSELRDQSIKCAYAANQLRGPAQTWFVRTVSVQPILLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4D6</accession>
    <name>A0A6A7C4D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_269360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4D6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29933" checksum="79D0C478FA5DC1A7" modified="2020-06-17" version="1">MYLRVALEVAIWGIHIQKSGIVVFLRSFLSVLRLLPPKYVKEWKKQNSKSDVFGAGLLVYGCMHLHHSDYFQFDWDIKAGRAPNPDKPIKEPLFPPELEKNYSQTLLDLVKQMVRIKIDERPYFREVLDRVQKATAGEPLRTASPNVPRFRPVDHQFYWILLEDKFPLNKKPIDPVIPKNSRPLTHLTPLAGDKGPGGTPGGKSNPSSAGAPQHTKQKAAPAPDPAQPHPHAAARPGNALAQLAARRAAKAAAQPAPAAHQPAQAPAKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4N8</accession>
    <name>A0A6A7C4N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4N8"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34611" checksum="058F6C9592492D08" modified="2020-06-17" version="1">MRLFLLPVSTRRSLVYCERARAPVAADAKLPVTERATRYASQTWAKWESAEKGWQKHVTVYGNRLLNRIPYTEWGLKSLPPATDKRRQAIDDGSLTVDCFYPRAFLPGGADGAIPALEKLATERQALDRRRLWSCVFWTPFTIPFQIVPVLPNLPFYYVVYRAYSYYRSLYGGKLLEQLLQKQRVNITDSQLMDNMYAAGLLHPTRPVAREAETPTADETTKLVKDIERRSNAGEEVMLLRRWNGKLIAEAFGLPEMEVEIERAVDQIEADLRAKAEGKAREGQEAAEKGTVAKTPMHGHKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T0</accession>
    <name>A0A6A7C4T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_256214</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4T0"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000004">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2862257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="763" mass="86938" checksum="40C5BE1556B85775" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C523</accession>
    <name>A0A6A7C523_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C523"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="16403" checksum="5830E653C1E370E8" modified="2020-06-17" version="1">MQCWVVKCGFQTIYQLRFLLKELGTANRVALLEEPDATMPEEDQNYFFALCGFSPCASSKNAEEPPAHPLELFLIEGDIIYTQPDACRPSSVPVMMHYGCLEDARISFDVSTNHPIRGELEILHFGSPHLTGFYLVSMAVSQSSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C577</accession>
    <name>A0A6A7C577_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C577"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="388" mass="42336" checksum="4B41FD9FD921502F" modified="2020-06-17" version="1">MAIERAMSTALSRSIRRTTPQWRYAAAASLIQPRVFTSSAWDSLPLRGKRFGGLSDAPSTYFQRPSLPANTIIKFVPQQTAWVVERMGRFHRILKPGLAILAPFIDRIAYVKSLKENAMEIHPQKAITSDNVTLELDGVLYTRVFDPFKASYGVEDADYAISQLAQTTMRSEIGQLTLDHVLRERVTLNTNITQAINEAAAEWGIRCLRYEIRDINAPEPVVEAMHRQVTAERSKRAEILDSEGQRQSAINIAEGRKQSVILASEAEKTERINKAGGEAEAILLKARATASGIDAVASSIEQGKQAAQGAVSLSVAEKYVDAFGKLAKEGTSVVVPGNVGDIGQMIATAMSVYGKVGESQAKAQAQRLIQQSPSQPEGEQTKIENGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5L1</accession>
    <name>A0A6A7C5L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_256535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5L1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="46176" checksum="C7154F98390439D4" modified="2020-06-17" version="1">MSKTRTVPVVTPNKVTLPPNELSEPKSLTAAEIALYDRQIRLWGRGAQELLRGSSILLIGLRALGSEIAKNLVLAGIKSLVVVDSESERCADGNGENGGRQGHVDDQDADLTEDDSRGCIVVQQDLSAQFLLREGEVGLRRLDAALPRLRELNPRVEVTAAETLGDVGSVGGFSVVITTDVTYPRACEINALCRSAGTAFYYARALGLYGFIFADLVEHEYALSREAANVETAIGRETATRSVISVEVVRDDQTGKAMETVRKRESYVPLKEAARSLLEESVRRNRRRLGNVPPLLPCLLALFEYESLNGGRIPVLGTQGDLKTFTELSMRKTKELGLQPTIVKAEFLRQLLQGLECEITPTTAFVGARASEDVVNFLGKREATIMNFAVWDGDALDGRVFALTGIEEKEDVGGTPMEGIVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5S1</accession>
    <name>A0A6A7C5S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein ish1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_268782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5S1"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025497214" description="Stress response protein ish1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44020" checksum="D122949183ECDF32" modified="2020-06-17" version="1">MKFGFSTITVVALASQCVVGNILGTDTSRHAYNKWHETELERWLSDHDVSFPTPADRKELLDKVQANWEDNVVKPYNKWDARQLSHYLQSQGYEIKKGTENNKDSLLKQVQAAWKDTANNVNDAYSQVQTWIFDSWTESQLKAFLDNHSIPNPSPRTRDSLLHTARANYHEAAKKAGETSAYPGNWLYKAWSDSELKEWLDERGVPVPQPGSRDKMIAQIRRNSKLAADRAQAQYSSLSKSAEAAQHTLSDALLESWSDSQIKEWCDRNGIKVPQGSKRNELIALARKHAAALSGNNAASSASKAYGAATTSAGNMYAQATAGLYGSFQNFYDQIMNNLGLASAEAKSSLSSASVRAASSSSSISSLASKAASSASKSASKKGENAAAAASSAARKASAEAKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C621</accession>
    <name>A0A6A7C621_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_211624</name>
    </gene>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Q6"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="366" mass="39718" checksum="DAE91DB58C738305" modified="2020-06-17" version="1">MFDALPGSVLVVHVLPYPLSTKEVIRDPPSRRHLFFDEKIEVTVVWKISAKQADIETLLRFLELTLSAHATDAAPQGPSSAGAATNHDIFVQTQPAHKSTEILTLDTHVYTLWRITVHLKCPLARRLLRPAIYFTATLTPSTTHKPSVSKELTPFEPLPANILAPLNRTLDFSNAPIYLGEDKLNKLSPPQSSTHGTPIRGATRRAFPALQALGTTIRYVPTSERSLLLLALRLETSQHVAGTFTLKRVDARVPEAQIYSLQAAAAEADQAVREGRVAASSPESHPTLEPLNGISLPLALAAGDVIVWVYGLDAHPSGVLVEMEVSIALETGTKVEIRTEGVHEGFASLVKEGVGLGIVEGRGRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6S1</accession>
    <name>A0A6A7C6S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6S1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8457" checksum="C5F048C53F111E90" modified="2020-06-17" version="1">MNALSQRGYCTCSGIFAPESIIIPRAPITNTARNIPHICWIQASPLARMRGICIAIQRYLLHYQLHYFPSGSCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Y8</accession>
    <name>A0A6A7C6Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_208208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Y8"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="19957" checksum="1B780CE0CDFD60FE" modified="2020-06-17" version="1" fragment="single">MGVDLDKHHVRSGHRKAPKSQNPYLRMLVKLYKFLSRRTDSSFNKTVLRRMMASKINKPPVSLSRIVSVTANPHSAKAYEGKIRAIVGPVTDDNRLYEVPKMTVCALRFTSTARARIEKAGGECITFDQLVQRAPTGSGVILLRGPKNAREAVKHFGMGPHTNKKPYVESKGRKFERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Z2</accession>
    <name>A0A6A7C6Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_211388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Z2"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="880" mass="100759" checksum="C5D3274D38B45D4D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C721</accession>
    <name>A0A6A7C721_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Meiotic expression up-regulated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C721"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39136" checksum="5133C3A7DD38ADBE" modified="2020-06-17" version="1">MHRTYSMRQSRAPTASQIQNPPPPSSSTKTNRLFGKASLTHSFRKTTAGAFGPDLAKKLSQLVKMEKNVMRSMELVGRERMEVARQLSVWGEGCDDDVSDVTDKLGVLIYEIGELEDQFVDRYDQYRVTLKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFAYQFDALREHSEKMAIIAGYGKHLLELVDDTPVTPGETRDAYDGYEASKAIIQDCEDALTNWLEQNASVKSKLSTRARTLSQRRRQGRVHQGEAMDLSGQDQAMEGRESGLWIPANQLRDGSYEHDDEHDEDMSSARGREEEREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7J2</accession>
    <name>A0A6A7C7J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7J2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="32633" checksum="A370F4E8C8FE0E26" modified="2020-06-17" version="1">MPRSWLSSECLHVWFPCIQYLRLTQTPLSWRHIIPLLKDKFSTWAPELPGYGLSSIPPSSDTRTVGHILIDALREIFPHQSIIWCGHDRGARIGHRLLVDKDPPIVASVLIDIVPTVEQWKSFSSPLASVAYHHWPFLAAPTTPRLISLMSGREYCLNRLKQAHGKSEEGTSKFQENNAIEHYCALFDKQEAIDGSCADYAAASTVDYEAQRKDQEAGRNISTATCVIYSVANLGKMHDVEKVWKYWVHGGMKFQCIGIGDQYGHYLAEECPDRIAKIILDWLEGLNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7U3</accession>
    <name>A0A6A7C7U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AICARFT/IMPCHase bienzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_210287</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="595" mass="65092" checksum="4526A6FC0E839DEC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C826</accession>
    <name>A0A6A7C826_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">NADH2 dehydrogenase 14K chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_241844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="10264" checksum="197AEFE1D765EA6E" modified="2020-06-17" version="1">MVSKILFWSGFGLAVRFWQLGIEMRPFMTKPYLYPFYCAIGASFGYYLQGVDEKQKRFLEEARERLMQKRLRRLEREGAEMGIGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C835</accession>
    <name>A0A6A7C835_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C835"/>
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        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="22756" checksum="D417B3960F31243B" modified="2020-06-17" version="1">MTQKKTVRFIDEVDPDELHIFHRSWSTERRESPYRPPPQSYKPRRHSPYHPPQPLSSTPRREKFSSFYNPSCPSSYPPTQSPHHPSYPLSYTSKKESAYQSPGRYVPSVDWRSSSARTHSAWQRESRNPSSSIWQGSATSRSGSRSELVEAERAYDSTSSTLSSYSTSRGGDLREGYRRERENYRRYGLKDGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8S5</accession>
    <name>A0A6A7C8S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_203897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8S5"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endosome organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25939" checksum="056C71CCE6001D0B" modified="2020-06-17" version="1" fragment="single">IDTSSVLLLPDLEKFREGTILVSERFGFKYDVFRSYTAARDTKGTIKTLHKYDSEEPQLYAAALAYFTSSTEILKEAGDEVEKVLKKIDEDGLMASLQVIQTLSVTHVATMGLVKRYLSTVVQREQDEIANNRRLIDIYRKDTTTKLGEIEELSTTPVSFSATRCSTCDMTLDLPIVHFLCKPSHHQRCLKELECPICAPKNATVRQVKKAQEESASRHGLFWDDLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Z1</accession>
    <name>A0A6A7C8Z1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_280161</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:6-phosphogluconolactonase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="364" mass="41010" checksum="4321D875ECDA6675" modified="2020-06-17" version="1">MKYNLIVGTWTPPGALFIFTFDSVTHRLTLLKRTPIPHDEPISWLTPSHNRKNLYGAGMKKWGSYTINNTTITHDVSLPLTGDPRAARSETKTRAIFCLAGRKSPYYVYCNPFYDHAGYINVQRVTPSGTLDRTIQDVRLEEKSAVHGMVFDEGEGYLYSADMWANRIWTHRKLPNGELEYVDSTPAPDPNDHPRWVSISRGDRFLFVLMEAGNRLCVYRLSSHKPGYTGEAYDLVPKGYNTTYPGMFRSDVCVVSPSGKYLFATARSNDKNFSGYLSVFELGDKGIERRVVMTPTSTSGGHSNAVAPCPWEEEFVALTDDERGFVEVYRFNAMELGRVARVEVNEPGFGMNAVWVEGESRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C911</accession>
    <name>A0A6A7C911_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C911"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="62" mass="6832" checksum="6D5ECE0D880CA16E" modified="2020-06-17" version="1">MAIRSITHPAINNVPPPKKTSALNASQKTQPPSNENSHPFTPSAFPSWIELEFEPVFLTVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9G2</accession>
    <name>A0A6A7C9G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9G2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19760" checksum="6CC8069D2190B83F" modified="2020-06-17" version="1">MASTEAVLLDFPLINDSSPPIEDLDPFDLNESSPKIQDEESMAEDLINQHKATCDSDICRNAYELITSSFFDLIQDLDARDIDSGNEERIADINEACLNNLLRKLKLLAGFQQYLQKHCPSGATSSSPDAERASKGLRLFRVSTLWSQETSPKRRAVRDPSGEMPMMKRRDTHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9M1</accession>
    <name>A0A6A7C9M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_255024</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9M1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="54"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1013"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2863338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127795" checksum="5AD12910C486EF22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9V2</accession>
    <name>A0A6A7C9V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_224199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9V2"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="314"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="663" mass="74180" checksum="C025E567E2945DBE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA10</accession>
    <name>A0A6A7CA10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_267703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="28281" checksum="BDD2C058D01B67B1" modified="2020-06-17" version="1">MDKWTLLQSAFRKGDLPETNNSPPLGELLEEVDGIQDRIWELGARYDLRGIHEISYALSLNLNAEEDDGSSDHDEPQVRCLLEDRSVMHVQLDKGYTFYPVVFNPALGNFGANAPPDFLKPTCERTEQRLSRAKNGAGVVSPGYWQAYSNVKKALKTEIANSEYSYSMEQVIALRVDQMFRERRSFKAIALPILMTMGLHLADQGKCDYTLRYLDLGASEIKAILDRLGGYVFTGRPRQSETNRLAKASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254116</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="258" mass="27791" checksum="8FC39C4E1AE2B3B7" modified="2020-06-17" version="1">MTDGCSDTGEHITDASGQLTYIPFPTCNETGRPLELLFGVEKDINCTIDFIDDAFFHLLEFYVHNDAPLTCRIPTKPLPPSALKDEFEKGATDHTDGQGSLSEVYTPMIVALAGVLQLSHVHVSTSLNVLVHAVPKRIAPGTIAAATAYSIARDPPTRIVIGDSLPLRFSVRWYPNTNLPSGWTGVGGHLTFSTLVYCLISAGASAAICLAYFRGVELPRRLRSHGKDRLGGMERGGLGGYGFANGYNGYGYNAGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CAG8_9PEZI</name>
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            <fullName evidence="14">Ergosterol 28</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sterol biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
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    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
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            <end position="30"/>
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            <end position="131"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864430.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15063" checksum="498A6B56ED7A22E8" modified="2020-06-17" version="1">MDLAKLLPPHPGYLPLWLLFISVVSIGNSVQAYISTSGTRQVYSSPTVVVTALNARTFGTWTAISSFVRLYAAYHITNKQVYELALWTFVVAWLHFIIEWWGFGTARWGKGLAGPIFVATFSLGWMLNVWGDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBM2</accession>
    <name>A0A6A7CBM2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A7CBQ2_9PEZI</name>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="24"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8852" checksum="F2BCC7AF6A636027" modified="2020-06-17" version="1">MLTHTLACKPVLILILIFVLTHTHTHTHTHTHTHTHTHTYAQAHTLSLSPYLSLTPSQTFLTVVDHQPCHASVTWAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CC20_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <dbReference type="Pfam" id="PF25545"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="438" mass="49618" checksum="FB2EB43F56F4AC96" modified="2020-06-17" version="1">MAPHRDLTADAGPKRKRDDGETPESPWPRKQLVTSVSNVSETQDSEEELDPVEHWILETNWPAAMSGKASSSLKRAREDGTVPVEVVDVRRGTLINDFSKNISKEANKAQALKLWADNITTSEFETALADMSGSNESAVVRFLNKFFFHDIRTLRKYLGEDKFPYLLQDSSALWMWKMGGTYPMPDLFYGVSEVFFDGNQQLGRLQDYMRNQKPAKCTASQYFPLLVCEFKSSSGSLLKGNTQSKYAAATVVQAIIELCEVADIDKLKSLEGHFLCYSVVANNETIKIFGHFFRQGTDDKITHYCYTIAVRNFFDETSSANADDIYKSHILGLIIDLLERAYKEHLKLLKDLVERLKSSDPAKDNERPTRLVLGDRYPNGHTKKRTISGKSRTGKSSMANTQQNNVTEIEADQNARRSAELMEEHTKNMNLISRLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Methyltranfer_dom"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="276" mass="30294" checksum="FFAB7D945C654D1C" modified="2020-06-17" version="1">MSSNKSTYAPGYVPSQITHHEWRTVENSAAYLLPTLRALSSKSDTSPLLLDIGCGSGTITRSLASHLPNGKVIGTDISDEILSRAKELCHGTDNVTLKLANVYSLPFEDGKFDVVHASMVLGHLDNPVAAYREMLRVTKPNGGIVANREPDLSICTYYPRSKPMDEFHALQLKVMGEGAVIGPKMVHLAMEAGAKREDITPSFGTWCYASPEERKIWGGAFLERLREGNLGKTALEKGYATKEEIEGMIKAWEKWSESEDGVYGCMLGEILIKKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRA8</accession>
    <name>A0A6A7BRA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_283713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006034">
        <property type="protein sequence ID" value="KAF2857632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRA8"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21746" checksum="27601B21437DCEE0" modified="2020-06-17" version="1">MAQLNKVQKSLQKKKKRTITALHPKSRDAHRLSRAQARDDRVAKTVSARQKANRPWLERVEFFQSKILPAEWNEMDLDDRSTGDARSLIKEFIARHDDELASLQKDRRPGRPPAQRQVLLEQQKERETSEFKSGFWVPDLLDQKTREKLMEWKKNDWLGLSNLNFKRVDDEGKVRESDFPPKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRC4</accession>
    <name>A0A6A7BRC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_261151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006073">
        <property type="protein sequence ID" value="KAF2857068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRC4"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="23546" checksum="A7B6124E06E18411" modified="2020-06-17" version="1" fragment="single">TRQLVFRRDLYAGTHLLTIIITSELLTSVPSLIYSEETVDTFSGPSTSYACSNSRGYDLPNECVIDDPQIVGRKLDCPFYFLGCTKQIATFDNWAMHCKYHFRTKLPKRLTCPFENCLWPVAAVTGEEAWEKLNEHIQKEEHQVHSKIDTKRRPNEDLIKHLWNCRIITSVEQKELTSYGTLERTTYVLTTGKGRNSNERIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRS5</accession>
    <name>A0A6A7BRS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_222412</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRS5"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="498" mass="55956" checksum="E135E763D81AACF0" modified="2020-06-17" version="1">MSTRKTVARSVSTRSRPKVGEAHGYEFGGPIGAALISFGLPLVCYAFTFLCNDVSGCPAPSLRFPLRLFSSTISQSPLEHALQTLKSETGWPGFCGLINAPAFLGSVAWYVLSLLLWAFLPAKEVRGVKLQTGGRLRYRFNAFLSATVILAACAAGTWVQGSSFPLWTFIQRNYLQLLTSNIVISYLLATYVYVRSFSVTPDNDEKRELAAGGHSGNVIYDWFIGRELNPRVKIPGFDAKVDIKSFMELRPGMLGWIILDFAFMAKQYHSYGYVSDSMILVTLTQAIYVLDALCMEPAILTTMDITTDGFGFMLAFGDLVWVPFVYSLQARYLSVHPVMLGPKIALGIVAVQLIGYYIFRASNSQKNTFRTNPHDPSVAHLTYMETRAGSKLLTSGWWGAARHINYLGDWIMSWAYCLPTLLAGYKIRDSILHPGTRLVSTDGMVGTAIPITYFYLLYFAILLIHREHRDEEKCRRKYGKDWDDYCRHVPWRIIPCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS54</accession>
    <name>A0A6A7BS54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_266493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS54"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="321" mass="35900" checksum="5EE7665EE8DC2E87" modified="2020-06-17" version="1">MLPRFEITNNTLDQVPASWLPNEIETQRRLVVFERRRHLDTIYTRTLPCSETSTSSSWLSDNMYAISCLWLGENYFFISLYNVTCLLGFLQHGNPHVFSMSGIWQFLKAAEPMPGRDSRFNNWFLSDLALRLQKNRCLPNSHVPMGYDFIPWGDLQVYLEKGFNAFGKLEKCVRRVDPGDQSFRGAWVPSMEHSADNQQDHSSGGLTSLPHIQAQHGEGAGGTNDPAGNNQQQLPCPSLGGISIPPWSGPSHRHEEDSYSRVNTASTDQQKIRDPLSFVSCDFDNHTTADGHGPKAAKEQEPQATKNTNTGNDDVNGSMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS71</accession>
    <name>A0A6A7BS71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_222032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS71"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51376" checksum="291CB45B9DBB4662" modified="2020-06-17" version="1">MPRFLALTHDKPTVSIELSSTKTIYTTSDQIQGNVVIYTPVALHVEDLRIDFIGATRTHVERGTTAVAVSGRTEAFHQFLKLSQPDISGHIPSDGILRAGTTHSVPFLFAIPEHLLPRACRHRVCHPSVRDAHLLLPPSLGGTGEDLAPEMASIKYGVYVKLTCCTIARVSEDGKREVQVSKARILRVMPRVEELPPLDTDGGGKDYTMSHVKTLRRGVLKGKWGTLTMRGSQPPAICLRPSIDKRHSTVATVDLQFDPHDELVSPPRLGSLHTRLKTITFFSSTARGDFPTKRIKETQDLTRGFHAESISLSHRWLAAVEWTRSEGRSYHARITVPVTLPVDKTFIPTFHSCLISRVYKLKLELGVQNMLGVNLTIKIPLQVTSVLAPSSPGGEPERLPVRAATPTPDYTEQPPQVDTPQAVDGNYVGEYFSTEEAWASLLGPNVLEDAPPGYNNTSTMLYVSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSC3</accession>
    <name>A0A6A7BSC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSC3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="212" mass="23007" checksum="EE61E05075B58421" modified="2020-06-17" version="1">MSSHGQPDFLGGGPPAGVTTGDLSAARLGQKNQVIAHALLACVTFAFIFPVGGILIRLPLPYYIHSALQSLGFIFYLAAFALGMDMATNTDLMHRTHVQLGIVILVLTILQPVLGIWHHLQFKRTGRRVVVSHFHLWIGRAVIALGIVNGGLGLDLARDLRTVAPSRGALVGYSVAAALMWLVYVAVAVMGETRRKRETGGQRRRERNLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSC6</accession>
    <name>A0A6A7BSC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSL2</accession>
    <name>A0A6A7BSL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_283682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSL2"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="4">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="896" mass="99426" checksum="B8C02C4FBB94EE3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSP7</accession>
    <name>A0A6A7BSP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSP7"/>
    <dbReference type="OrthoDB" id="5368821at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="661" mass="73023" checksum="1ACA56B979E17D49" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSS1</accession>
    <name>A0A6A7BSS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_260270</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTG8"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="100"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="23025" checksum="21FABB107DF07B12" modified="2020-06-17" version="1" fragment="single">RGMIATLMICIIDQVRLPKEILLHGIYIVDRLLSCHPSINNDRMELMGLTALWLAVKFEYRNAPSAESMVSVLHSGYSATELIESERFACNALEYRLVYPSPASFLREYLIATCWGDDIHTLAWCLIHVSCFENGFVGAKPSLVAAAALMFTRQVFLLDEWTSKHSEVTGYTAEELRSLVGLYKAVIASSNGHRPFEEPFGSPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ2</accession>
    <name>A0A6A7BTZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTZ2"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="16763" checksum="5EED92DFEDCF6558" modified="2020-06-17" version="1">MAQSGVGVAPECVEAFNELKLGKSTKWIIYKISDDWKEIVVEEKSTDPNFDVFREKLLNAKSKNKRGEEGVGGRYAVFDVDYDAPGGEGKRSKITFISWVPDNAPQYPRMMYSSSKDALKRALNGLAADIQANDIDDIEHSSIVSRVSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU00</accession>
    <name>A0A6A7BU00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_221323</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU00"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="315"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2858437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="508" mass="55690" checksum="F3AAAD54B3AB34C6" modified="2020-06-17" version="1">MAQTKRKIDAAESKATKRVKVLSASGNGAQDKEEAKAVKQAKEVKEAQKGQREQKVQETDKGHKSHEEQKVQKTEETKEAIKNFADLGVTASLCDACDACGFKTPTPIQRQAIPLALEGKDIIGLAETGSGKTAAFALPMLQALLDHQEPFFGLVLSPTRELAFQIKQQTEALGSAINVRCAILVGGTDMMSEQIALAKKPHVVVATPGRLLDHLENTKGFSLRKLRFLVLDEADRLLDMSFGPAIEKILQQLPRERRTLLFSATMNKLDKLTRAALRSPTRVSVSASDHQTVKNLVQRYVFCPYDHKKVYFVALLNDFLGKACIVFARTVNETQLLAFLLRSLGRSAIPLHGQMSQSARLGALNKFRSGGREILVATDVAARGLDIPSVDLVVNFDIPQDSKTYIHRVGRTARAGRSGVAISFVTQYDVDVFQNIEKALGKKLEAHDMDKASVLSLSETVEEANRQAIKSMKEYHDSRKKDSKKIGISGGRAKKGASKGGQMDLDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU67</accession>
    <name>A0A6A7BU67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_259618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU67"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="13">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="157"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2858622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="433" mass="49149" checksum="1184BB8EB69C0740" modified="2020-06-17" version="1">MDDDERNEELSALQAIYPDEIAIDLSNYIATLDVNVILAKPITVHFSSDETAVLTRLPPLRLRMSLPPGYPGRKAPIIIITSHHNWLHPCERDKLEAAATTLWEESGHGQMLYSYIDHVQQTAEQGLGLDWLVLPGHLKAPLETYEEAAKRDEFHQTSFFCGICLDPKRGFDCYRLEGCGHVFCNSCLQAFYSDAIAEGNVRAVVCPDATCTSTRRALHPRELLAMGLEDAIARRYVVMKRKKRLDADKTTIYCPRSWCQAPARGAKVPPIPPNLNDYIDIDDDDDVDKPIPIDTPNEIDRLSICEKCEFAFCRICHKSWHGEFTRCRPPNSEEEISAEDQASFDYIKYHLSACPQCSAPVQKTYGCNHMHCNLCQTHFCYLCSAWLHPANPYAHFNQVKSSCYMLLWEGEEGDETAERDVGEEEMIDVVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU98</accession>
    <name>A0A6A7BU98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_272233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU98"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="38026" checksum="2B54AD76BB891A85" modified="2020-06-17" version="1">MLPYTHELRIALLAVQRATILTRSVFHRNAKGTLDKSDASPVTIGDFGAQALIISALRKNFPGDKIVAEEEAKDLRENGKLKELVFGLVKESRLKDGEGERELGGGIADEESMLKLIDEGGYEGSGKGRFWAIDPIDGTKGFLRGGQYAVCLALVVDGEVAVGVLGCPNLPVSDSEPLTEGIGANASDEEGRFGVLFSAVTGQGAQSRPLTQGELKEGHTIKMRPVNKLPEATFCESVEAGHSSQSDSARIAEKLGITNPSVRMDSQAKYGSIARGAGDLYLRLPVRKDYIEKIWDHAAGDLIVREAGGEVTDVDGKRLDFSRGRTLLHNKGVVAAPKSVHAEVVKVVEEVLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUE4</accession>
    <name>A0A6A7BUE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_221958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUE4"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </ligand>
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    <sequence length="878" mass="96413" checksum="62CC2298BF195616" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Crous P."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54931" checksum="07E76A723B9C320A" modified="2020-06-17" version="1">MAEDDKEKAEKLAAAKKRFEQLKKEQKKGKKKLKEEDDGVKTEEAETAKAEEPKAAVTKTDAAADGGKLPQSKSRSASMRSVSGPSEEVRELCKKQSARIEELERENKSLKVQNEESAARQIKTEEELEKLRENSSEIAAIRSKAKEADSLAAELESAQRQLVQAQHAAKGASRRASFVTPDANDQLASKTAMVESLELETSNLRLQLKKAEEKMAERDGKIKAAEEKTRTAESATEELKRKLDQLKASSTKPEGESTVSTKRVGELEAELREMRANLDAARSKASGLEQKVETLAKLHRDAEKEKEKEKEKEKEKAHSSPRPDQGSDFELDSHELEVEKLRSHIRELESENADLRRGVWRQRRAELQPSMDDQEFYEDVDLDSVSARRSSFRQSSTFQDVITSGFSAFARRGRARTQSLGLLDHDGEIDPEAFRQAQEEEAKKRVERVREIKRGLEKWRGWQIEGLKEQRMDYPVPDWGVVFDV</sequence>
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    <name>A0A6A7BUW9_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2859000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="20741" checksum="B7DA45A1D8D2DBE4" modified="2020-06-17" version="1">MQLCEPRCFSGYAGESLDSGHEGASFSYWTNCATNQTSSRNPMANHSPKTSYQMRVISTPPCTTTTWCTGNGNLSDKQYSVVCSLVGSTLECLNLYHVGYCLPTRARKFGLWLWNCLVVLHHVPSIAEPMAISVHHSIPSGLICKRTRHQYWQDLSSEFVTAQPRDGRYQFEQTITVSSSYLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV64</accession>
    <name>A0A6A7BV64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_300749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV64"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="362"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="570"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123587" checksum="7627DF16957C5065" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVG7</accession>
    <name>A0A6A7BVG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_295748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVG7"/>
    <dbReference type="OrthoDB" id="5420377at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14706" checksum="AFE5D734FE10692F" modified="2020-06-17" version="1">MPSNTRCQPLIEITNQRKSRHDIFEWQGGAIVARYNAWEGPVNVSNAEGLPQSTVTNIIRRAKQDKSVENRPRSGRPKKANKRDERAILRCIRLKPKMTYQELVQEVGLTLSRQTYRQILQDSKIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVI8</accession>
    <name>A0A6A7BVI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_259131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVI8"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="330" mass="36833" checksum="057BD473CCA7076B" modified="2020-06-17" version="1">MVLHNPNNWHWVNKDVSSWTNDYLSKDLVGLKADGDDGTHVEVSKLLSMDGDVDVSQRKGKVITIFDVRLQLEWTGTLPGEKEDDVSGTITIPEVAHDTDEDEYVFEVEIYSSASSKEPAKDLVRKALTPQIRKRLQMLAPALISEHGKDLQHPPGTDPSANFAKSTVLQSSSVAKSGNRPAGKTETTSSDNVNVTKFSDTQEFRTTAEQLFQTFTDPQRIAAFTRTPPTVFEGAKEGAKFEIFGGNVSGSFVTLDKPTRIDQKWRLAQWPSGHYSLLKLKFEQNDVDGVTVMRVDWEGVPVGEEETTKRNWNDYYVRSIKTTFGFGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2859250.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="9934" checksum="D3E409701381B8C2" modified="2020-06-17" version="1" fragment="single">AIDTWAHPHTIRSFLGFKNFYRQFIPNYAEVVLAVERLAEAGSKEKHRTKNQRAVEVFVLKPGQKRVRTTARGLSKDIGHTIIVYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW08</accession>
    <name>A0A6A7BW08_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_265263</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA-bd_8"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="506" mass="56393" checksum="FD376D751C98D7F0" modified="2020-06-17" version="1">MAERMDVDTEPPAAASDQPQLNLVDPKTAEGAVAVRSIEGWILIVSNLQEETTEEDVQDLFSEYGQIKNLHLNLDRRTGFVKVWGHHPFQLEGYAFVEYSTLDEAQAAVEGVRGTKMGDNIIGVDFVFVRPPPGKVLARSRSGFGKDRRRGGRSASPEGRTRGGRSASPEGRTRDLCIYVEPLDLIFCIMPRQEKQHKRESTSFNQGGNEQSKKDTQDSKSRIGKKIDELLPWKLSPPKGASNEENKPQTQLQSKQRGEEDSRFDSPNTLFKPLEQTNLQDTFKGEAEAKTPQSSSSNKFKSKVLDFWKKPITNRLTKGKPEPAAPERPQPTTPTRGRSLSANVPPRPPLKPDDYSPPSALSVRSGVYRTSSERRIAHLYTPSVPTRISTVKIKKPAPFDESQKEPAPENDNNSRAEPTSAPDNDAKTKPASVPYTEPQTEPAPVPNTEPQNVPDPTQHESEMEQAETKRTAEEARRATEQEGESKQEGQHHQERTPEKEKVPNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW15</accession>
    <name>A0A6A7BW15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_295690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="81" mass="8980" checksum="2C1924668112E725" modified="2020-06-17" version="1" fragment="single">LPKDAGMLPSHWPWNHKIASIPGRKRAIRGKCPFSPSELQCNKKWVDDMLLKGFILRSTSPVTAPLFSATNPGGVHICHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW69</accession>
    <name>A0A6A7BW69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_258785</name>
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    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
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    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00116">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="463"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="440"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="655" mass="71086" checksum="74E91F50124C18C5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWC2</accession>
    <name>A0A6A7BWC2_9PEZI</name>
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            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="13" type="ORF">K470DRAFT_220604</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="33082" checksum="6FC4F1A7E6F2EA41" modified="2020-06-17" version="1">MSLPSHGHTFTARKVGAPNTLEHRIYIERDGQPVSAFHDVPLYANDQQTVLNMIVEIPRWTNAKQEIALGEPLNPIKQDTKKGKLRFVRNCFPHKGYLWNYGAFPQTWEDPHVVHPETKQKGDNDPLDVCEIGELVAKPGEVKQVKVLGVMALLDEGETDWKIIVIDVHDPLAPKLNDIEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNKKYAMEIVRECAESWEKLITGKTPKGDINLTNVTVPHSQDRVDPSSLNIPAGENKAPAPIDPSIDKWFYISGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWL6</accession>
    <name>A0A6A7BWL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_97121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWL6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="11227" checksum="98D74348A47295DA" modified="2020-06-17" version="1">MPLSMNETMTRLRENFLYRGKNPEKFRLLSMVLVMLVVALGRSCRALNKCISPAELDLELLRGKMGLDFPRLMHLNTCASWRFWSSEHLIGFKHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWP9</accession>
    <name>A0A6A7BWP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_218511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWP9"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="325"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="736" mass="81610" checksum="78D00A91580C067D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWT2</accession>
    <name>A0A6A7BWT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_277565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWT2"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17194" checksum="CEEA7A1EEA918D7E" modified="2020-06-17" version="1">MASVPLPKRIIKETERLHTEPVPGISAQPHDDNARYFDVIVEGPAGSCYEGGVFSLELFLPDDYPMCPPKIRFLTKIYHPNIDRLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPEDPLNEAVAKQWKENQDEAIATAREWTRLYAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXF1</accession>
    <name>A0A6A7BXF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_93031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXF1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="204" mass="22770" checksum="A7F8118C09850BFC" modified="2020-06-17" version="1">MFCHRTVDKHLLLENPPLSSLIYGKREHPVRIDLIPQSARQAKFLSTTTTTTTGQHHIRKKETTEMYMPLVKGSYPLLPSTSSTVSAKQQPFNNHPKTLPNNTTSLKHPHTSRRHHKRDKMSSRQHKTKQSSSSSSASNTSSASTGTGHKYLRPHELCAIELWNNEILSSKSGAGEKSRDDVVKEYVEAKMAFLAGRAQEGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXH3</accession>
    <name>A0A6A7BXH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_218769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXH3"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="21395" checksum="E0A4FB57C4A8CD25" modified="2020-06-17" version="1">MAEAESTPASSNEEARPPKQVIYCGICSLPPEYCTYGGTTKKCSEWLEQNHADLYKALYSADSAAEGLSTLSVDAQKRAERDAAKKAAKAEAAEQRETEKRAASRVLVRRVERSKRKCATEISGLDHFGLDLKKTAKELGKKFATGSSVTKNAAGTGEEITIQGDVGADVVDWISEHCPQVPDENVEMVEDKKKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXL9</accession>
    <name>A0A6A7BXL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_97460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXL9"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025424978" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="181"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="558" mass="62236" checksum="27E319895A5197F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXM1</accession>
    <name>A0A6A7BXM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_271698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXM1"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="40923" checksum="B67BE52605769FC6" modified="2020-06-17" version="1">MDDLDEVESLRRFLEEQRKVASPEVSTGVLEDAEFIADNAIDVFPDLNGTRSAAKLIAESMEKRGYSLRSWSAHSLHPSREESSDVELVDYVFMLDLLNFSFWSVRDEKERFKVEYRDKVWTGYDSLLAALRRALDEGIPVTRPQFWGEASDEKLRHVFRSATDEEMPLLSERVDILRGAASVLKGLEMGSVYQLIEQSNHSAIRLINLLTKHFSSFQDTAIYKGRKVHFYKRSQIFVADLWGAFQDSSIGHFTDIDSLTMFADYRVPQMLHTLGVLSYSPPLLEAIKDGKEIPSGSDWEIQLRGCSIWAVELIRRRINKSNAVLIDFYLYDLAKEKERSGVKMLPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYA5</accession>
    <name>A0A6A7BYA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="532" mass="58205" checksum="790BB814660A80F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYB5</accession>
    <name>A0A6A7BYB5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_219075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="289"/>
        </location>
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        <location>
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            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859518.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="92154" checksum="E50B632CABA8A04D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BYK9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_233072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Proline utilization protein PrnX-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="420" mass="46518" checksum="E53BD9C805A6A6A0" modified="2020-06-17" version="1">MMPLTVLRDADVDRILHSYTREDILELQRTLADALHWYSTSSDANDYCSDFQPERIALNRKDGSTTFFMPASCIDGQAVKVINLSGCVNPKPSSNASEKYVDGERLDAKGAISGSLTLMDSAGNTTGLVHATELTAFRTALASTMLLKKRSSVHTLTVFGAGLQAYWHIRLAMLLRPGEIHHLNVITRNFERATKCLIRLYDPQPNDPNFTNNVDERYNSKTKSTILTTVHSEFQRLRKNHIRSADVIFCCTPSTTPLFPAECLTNPEGQKKGRYVACIGSYKPDMIELDPDVLRFAVSQPQKHHRLHRRSREGGAVIVDTVTGALSQAGEIVQAKLLPEQVVELGELVMLSKEAKARRAAVGQSVDEGCNFQDDEALQDWVTRGNVLYKSVGLGLVDVVVGNEVIDRARQTDIGVTIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYL2</accession>
    <name>A0A6A7BYL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_258121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYL2"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="331"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="603" mass="66159" checksum="08B781AC1842D003" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYQ5</accession>
    <name>A0A6A7BYQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_233719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYQ5"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="674"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="817"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="962" mass="107176" checksum="5DC22369935D11D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS5</accession>
    <name>A0A6A7BYS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_194830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="16885" checksum="5739229C409E3DD4" modified="2020-06-17" version="1" fragment="single">ESYHSYEPDEYHTVHFGNILHNERYRILHKVGYGRNATVWAARDEQKGLRCVAIKIFKASARPNRETGIMRILAANRTKHPGLAHIPVLLDEFELVGPNGTDPCIVTDIYGGRVVPDSSDSSAEYTASTASRLQKQVLQAVDCLHQHGIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYW8</accession>
    <name>A0A6A7BYW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trihydroxytoluene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
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    </dbReference>
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        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="33964" checksum="953A91649BAFB93B" modified="2020-06-17" version="1" fragment="single">MAHGVTVPDTKGLSPYDESLAQWRQRNGIDPTKLINLTRISHVRYQHPDLDRITTFLIDFGMVVAKRTPTEAWFRGYGTDPYVYYACKGERKFLGGVFEVDDYGEMEKASRMKGAGGIVSLDYSPGGGYMLTLHDLEGFPISLIYGQERATKGEFPEKIQYNYEDEKPRIRRFNRFEVGPAAVHKLGHYGFCSQKFERQLDWYTRTFNFAPSDFLYVTDGEGKRDIGVFMHIDRGDEAVDHHSLFITQNETRHVHHASFEVHDFDTQHIGHQWLRKRGYESVWGIGRHILGSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ36</accession>
    <name>A0A6A7BZ36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_270721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ36"/>
    <dbReference type="OrthoDB" id="3643499at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="271" mass="30745" checksum="54C00399520C58FD" modified="2020-06-17" version="1">MANSESMAKLFANLIADMEQNVHVAKEKFCIAKSQAAVQGIYFRKDRVLREENRQQNKQRRHDKPADTLHPQWTAQTFYDTTRQYYEEYQQRWIDLSPSDPNIPFPVQGLEADNLLNSTNITAPTCRSAPSAWSPGTVMKANTQVFFLKGIGLMLTYTQSSETANVNIGFNKTRATPEQIRKLDAILKETEHLPTIENESGLVAFATARAGKVVLWTLEVERRKHLQWKLVDLRIEISPSLSGVSPTPACWARRKVVGKGEEVMDGARLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ43</accession>
    <name>A0A6A7BZ43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_218033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ43"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00652">
        <property type="entry name" value="TBP_TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
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        </location>
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        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="216" mass="24222" checksum="9D8207EC6F10A71B" modified="2020-06-17" version="1">MPFKYPVQWRSNFVNAVAPARPATTPATVPDPRYLIPTVQNVISVVTFDCQLDLETIASKAPNCKYDPDRFPAVVMRTRDPSTAATIFESGKVVVTGARSERDSRVAARKYMGIIQEVGFRAKFKNIGIHDIVLLYNVGFPVYLEGIASTHHMFSSYEPELFPGLVYNLLLLKVRLIIFATGRIMITGARTRGAAYEAFNLFYPVLLEFRRARGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZC1_9PEZI</name>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="30474" checksum="9AC2C7FFFBE215DD" modified="2020-06-17" version="1">MFQKRTYQLSSGGQTATHFIHEECTPSDITTYKKEAPADSKTANTHANINTGPPSLNQSTIADNNACIKLAFASVLESSVTKPAAFPIAAANFAAMQRRLVLNAERYQSTGFRSSKTLYPNAEWSELWHYGILACTSGMAYYLIKFYGRKVSKQVFGRDKIAAKTILDSVWHYMGVVCSDRSRKVARISLSKAKARVNQFKYVMDNFRTQTSRLELWRPQPTFTSQIIKAQMGRSAQLQRLLHCNGGDVNAAMKLYTSEGYLGHKSLLVTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="18329" checksum="CBD47CEC64E435DB" modified="2020-06-17" version="1">MTTIYCAYTEPINPSGTQPVLTRSQVWAGLQRKIRRAQDFVPVIIACEVLEEKKDEKDVPTVVRDVVFKGKDEKVREVCKSYWPSRVDFHQSSGAVITNTLSSGSALDETDLYMTYSFEFRHDEAVNYAEKEKEYKNLAKMAVHESIVSLREMGKKGELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0D8</accession>
    <name>A0A6A7C0D8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0D8"/>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="500" mass="53930" checksum="F1ECD54C078D5B3F" modified="2020-06-17" version="1">MTLMELQVRLSSYTQQFNMQDAGRVDPHFWTVFEPLLLSISESRNLQNIEILYNQCLALSNSFAAASDVCFNAKSRLTAAPAEHMISTRSGLGNIAGPAPRAQPRSVFSTQNLHGSRPLPPLPCENQEANRRLSDEGLAPSSDDSGAGRTKSESSTKTLDEFDTRPLPWIPGFHGSKVANDLGFLIPAEATVGPMSRSPSPDSGRAPRAERTTTGASYTETADGLTLFDTRPLGGLPGFNGSRLNEPGFPIPPFPSNTPLSASSVFSEHSTATHEHGTNRTTSPVRPTIRSSSEILLDSTTYSSPTPPGGASRTPTRRVFTETDANISSADRNGQRLPISNSRPQYIAPQPYKTRYGTYITNELGTTYRVRMPTSETPPELPSRSQINAPTSEPNDILTLAREARMRTYSDISTASTTPPGSPLHYQINGPTPDTRGLLTAAREAHMRRMNGKTSPSVPPLPLAQPSASASTSVEYRPNRGNSVHVMERIEEGGGSKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q4</accession>
    <name>A0A6A7C0Q4_9PEZI</name>
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            <fullName evidence="5">WD40 repeat-like protein</fullName>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Q4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <sequence length="1008" mass="111623" checksum="A84CCFFED03AC870" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C137</accession>
    <name>A0A6A7C137_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <source>
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        </source>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="187"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="21"/>
        </location>
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            <begin position="22"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861059.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2861149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2H7"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="107"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="319"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="395" mass="44352" checksum="6584276AB5F66F14" modified="2020-06-17" version="1">MRNSMEEGDTERGTGLPGYNDVNDPFKLRDALMTDEQMAAIKANSRRKRIPLGKSPRAALHAHKLRGFYRQQNEKIERWLKPVHEHVQDARDEQGSDALQYRIAVGASLIANILLAVIQLYAAIGAGSLSLFATAADAVCDPLSNLTLLLCHRAVNRVDPRKYPSGKARIETAGNITFGFVMACISVILITVSSIQLLQNEGRNELKPLKLTPIIVVGVAFLTKFSLFIYCFALRNKYSQVRILWLDHRNDMLINGFGLTTAILGSRIAWWIDPAGAIAISILIAGIWIRTCYSEFQLLIGQSADTAFLQHVTYISMTHSPLITQLDTVRAWHSGPRLIVEVDVVVDKVRTVEETHDVAEDLQRKLESLPDVERCYVHVDYETSHAPEHFWKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W1</accession>
    <name>A0A6A7C2W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_245608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W1"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="90"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="39648" checksum="0F6CB298E4264FB7" modified="2020-06-17" version="1">MSSPLQHLRGVILPAAADMHVHLRSGTMSELVVPTIRQGGVNTVFVMPNLQPPVTSVEGAMAYKAQLEKLEPGVEFLMSLYLHGDMTPATITAAKKAGIAGVKSYPQGLTTNSDSGVVSYEDFYPVFAEMERLDMVLNLHGEVPSSQDVGRDVTVLNAEEEFLPILKELHARFPKLRIVLEHCTTAAAIETVKACGPTVAATITAHHLFMVVDDWAGDPHCYCKPVAKLPRDRWALVKAVVGGNKKFFFGSDSAPHAIESKRADSVAAGVFTQPHAVGYVVEALAEAVRQRVVKEEEITEEGLANFLSGFGRRFYKLEEDKGERIRLVDQIRVVDVLRSKDDGLEVVLFKRGQMVWGVEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C300</accession>
    <name>A0A6A7C300_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Poly A polymerase C-terminal region-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C300"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="855" mass="95659" checksum="D602704ECB78DE75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3L5</accession>
    <name>A0A6A7C3L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_245115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3L5"/>
    <dbReference type="OrthoDB" id="3943081at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13381" checksum="4D82FD8C1478F13C" modified="2020-06-17" version="1">MPTHRSNLSEPQEHWHDLKKHPQSVHFREAAQKEYDALCNRENFEVLKAKLCARGDLQPVTKDDAYSATLVAKVFRVLMSITAACGLETAQLNAANAFVNAPMTETVYVRNPPAFHKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C414</accession>
    <name>A0A6A7C414_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C414"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="289"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="499" mass="53817" checksum="8C8B6E80006204B8" modified="2020-06-17" version="1" fragment="single">MNSRRVYRTVAATSSRLQRKKQHFYRSLLVVGIAGGAVATLSSKKSLAEVPPSKEEYRNLISSQHRQITQSREEPGVYAWGNNSGRVVAPDSTEPVIKTPRRIPYFDGKLLRDIKLDQNFGAAVDQHGDLLQWGAGYSTDNTNPVPTLTGKNIISISLSKDRILALSRSGAVYNLPVSATEQASGPKPHESSWLPLWNPQSPISYKLITPNSLNYSEKVSSIATGLDHILLCTNKGRVFSASTSNTPPTQGQLGVSPLPPTPPYELTTLRSITQIACGDAHNLALAQSGRVYVWGSNASGQLGLEFTSETPIITEPCLLPLQKLYREGPWKATRVAAGGNNSYITVDVETSNRLVADTLAFGQGIHGGLGNNRWTHAQHTPTRIPGLSGLREYDEVRGVTVPIRLAELVVGGTHAAAVLDNITQTMDGGGGRDVLFWGGNGSFQLGTGKRNNVPVPMYLAPLGGDEGGVVNRFHLAPRGREMEQRVHCGRGATCVFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C481</accession>
    <name>A0A6A7C481_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_255960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="555" mass="60628" checksum="265A35BBC86F9007" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Goodwin S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2862374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="61" mass="7137" checksum="4B9C3BFAEC111EF3" modified="2020-06-17" version="1">MFSMLTFKMKPFCAYVEADLADKIHPHMPQQTMTLSRVETQNHFYGLTKPSSHDGMMRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C5E5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5E5"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="217" mass="24275" checksum="890CA9C213E436B2" modified="2020-06-17" version="1">MSKITVAGVRQNVQQLLQYSNEEKKRNFLETVELQIGLKNYDPQRDKRFSGTVRLPRVPRPNMSVCILGDQHDIDRAKHGGVDAMSAEDLKKLNKNKKLIKKLARKYDAFIASDSLIKQIPRLLGPGLSKAGKFPTPVSHSEDLSNKITEVKSTIKFQLKKVLCMGVAVGNVDMTEDELVGNVMLAINYLVSLLKKGWQNVGSLTIKATMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5F0</accession>
    <name>A0A6A7C5F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_163618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="22357" checksum="C1FCB8828A1BCFAA" modified="2020-06-17" version="1">MPRRLLMARWKSFVELKDVPRRKDLNIRMPHTSLCNLKLSWVYCLPLPHSPPFPSLLLSLLSSFPFSPPFPSLLLSLLSSFPFSPPFPFPLVPLTASPLVRDARPSLGAVHRHTTLFGWYYSTGAIATSAPLTVDCTFHIMVVEPVSIMHQLSHFSVTSTFRAQKSHSKIERVIMSQEYSHRTRRPNKHRLGRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5J5</accession>
    <name>A0A6A7C5J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_275239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5J5"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="11"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="39718" checksum="572858633C061D2F" modified="2020-06-17" version="1">MSTSIASVLHGPKDLRLEPRSLPTPAPDELQIRITATGLCGSDLHYYHTFRNGSIYVLEPLSLGHESAGIVVAVGSSISPSTFSVNDKVAIECAIPCSTCSFCTSHPSRQNLCPNLRFRSSGKLYPHFQGTLQQRINHPARWCYKLPEQMGCEMGALLEPLGVAVHAWRRAQAERGERVLVLGAGAVGLLCAGVGMLRGMDVTIADLDVGRVGFAVENRFAGRKVVLSPPEKDAGVERMEGIAREVGEFDLVMECTGVPACVQLGIYAARPGGRVMLIGMGHPVQTLPIGAAALREVDLLGVFRYTDTYPESMEIVSKALDDPKAPDIGKLVTHRFRGLESVPDAFERAGKSRDEEGNVVVKVMVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5J9</accession>
    <name>A0A6A7C5J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_262545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </feature>
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        </location>
    </feature>
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            <end position="135"/>
        </location>
    </feature>
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    </feature>
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            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="473" mass="52511" checksum="9BDA3877C7D36469" modified="2020-06-17" version="1">MSGCLADMPLPGLPASEMEYQDGCASPVWSRMQKPPSPSYLKPAAQQATPHSVPSLSDGTSDDPDSAFASSPCPMNQRDSSSSLDSEELAGLPAFLAKYKKDGDDMSESDVASVMAFSTIDDDYPSQKKRQEMREQQSAMLSQRAEKILANAKSQLSQMEGNLRGARDLCQPLTAANLQRASTSYPAPGRFVPDGYHCEYQNRESVAEIPRREPVRPQGRRIPVRASYSSLNQSLRSSRSYDSGMRKESSPKADELREQMSCLRGKISTLRDRAREDSIRRRSHMESRNISPLNNAEAYYRRDSGATMSSMEKSLPRKLILPGAFDVPHEERDDAFDYQQTVIDHPPTEKSDPAEKSDQTATQSSASVRSSETARPESPPSKRAASRASVDTFATATDMPRRSRSLSRSTAVTLKSLLSSDLRTLSQQDQALIRSVIGSLRETCLGLQEQDEDAYECRIYRRRLDEAKRILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5K1</accession>
    <name>A0A6A7C5K1_9PEZI</name>
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            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">K470DRAFT_269508</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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            <begin position="28"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="525" mass="57490" checksum="60172A0029C7B60A" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7C5L6</accession>
    <name>A0A6A7C5L6_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="23836" checksum="A45533E0F0FC0F42" modified="2020-06-17" version="1">MRSSAIFAAPFVAAVYAQSNMDNSSATQSAAAASSDVATTSSSYVYSNPNTAFLTMTNSFGVITGQPAPITAASSQDTAQPTLATIPAGLPDGTTAIVMNISSTLTSFTVQVSGSSTAVLGAGGVPVVVPTAAGGASSSASGAAAASGSDSSASGSGASGTDAAGAAGATGSGATASGSDSTATATDSGSASTDSAQSSGGSDSQSSGGSQTSGGSGADSTSSGSGSSASSSGGSGQKSSASTVVVSAGLLGLGVFFAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C5P2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5P2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12723" checksum="9083CC6BBCE0A52B" modified="2020-06-17" version="1">MGRVGFELDRRCLRRRNFDGRRNGWRGRLVRQKRGLRRVGRLKPAKRESKPEGKTPPAKDSPGRRNPPAAKPSSASGPNEKKPSSANGEKKPFVANKPKSSNESKHAKQPSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Q1</accession>
    <name>A0A6A7C5Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_280738</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Q1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="183" mass="20925" checksum="A2A24D6C409EB596" modified="2020-06-17" version="1">MGLTFSKLFDRLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIVFVVDSNDRDRIVEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRSWYIQSTCATSGDGLYEGLEWLASSLRKAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Q5</accession>
    <name>A0A6A7C5Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Q5"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="46968" checksum="2A09148828FD34B7" modified="2020-06-17" version="1">MASQDDVGPKVPRKRFVGRKKAENRQHTDSSSLETAIEPAVRRTPRLLNTVPEEIRNNDAINEAIALLPPNYNFEIHKTIHRIRSSGAQTVALQMPEGLLMFATIISDILSEFCPGTSTIIMGDVTYGACCVDDYTARALGCDLLVHYAHSCLIPVSTTAIKTLYVFVDIQIDAEHLVATLARNFEPGRTIALVGTIQFNSTLQGIAPRLRAAGYNVTVPQIAPLSKGEILGCTSPRLAKDQQVGCILYLGDGRFHLESAMIHNPTMPAYRYDPYSRRLTREVYDHTTLMSDRGDAMRKAASARKWGLILGSLGRQGNPHTLTLIQQHLEQRGTPYLNLILSEIFPGKLATMSDDVDCWVQVACPRLSIDWGYAFPRPLLTPHEALVVLGGRQHWHDGVYPMDYYGKDGLGRVRQEDVSCKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5V5</accession>
    <name>A0A6A7C5V5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_10331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23020">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="568" mass="63141" checksum="8714E0124DAABC5F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Y6</accession>
    <name>A0A6A7C5Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_167058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Y6"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="372"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="454"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="700" mass="77955" checksum="00AC081F3903F179" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6J4</accession>
    <name>A0A6A7C6J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_211248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6J4"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="526" mass="57917" checksum="6F239F1C917484E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6W3</accession>
    <name>A0A6A7C6W3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9 11">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_211405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 480.64</strain>
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        <text evidence="8 11">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 11" id="KW-0926">Vacuole</keyword>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="546" mass="59343" checksum="4DF2ECFB79910F35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C6Y9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="180" mass="18748" checksum="FB184A008A6A2BB9" modified="2020-06-17" version="1">MPSNCNTILPEDSVSQVAARMSKACCPKPPSKASAPKSAHEVIPAMIPAEIIMPVAKAPSKASSYKSKEKAPSKVATKMSTKEASKAQTKEPSKAPNKAPSKKASKAPSKLPSKDPSKAPSKEPTKAPSKAASKEPSKAPSASAKSAGAAAVSTCHDNGCYSLEMTYKLRRCSGKCQHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C704</accession>
    <name>A0A6A7C704_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Peroxin 26</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_293597</name>
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    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C704"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38643" checksum="8AD6BEBF0CBB7957" modified="2020-06-17" version="1">MAPRSRSPNSTNIIRAYKSASQLYLTKRFGEALTTLTPIITPRKDAPAAVSFSARGTRTKVWVFYISLLHALVELGSEDGAAAVGAVKWQSLASHVRSGAVWNEVVESGYAGKEEAVDEDVVINLTTLLLAHMSNQRTNQRRLETWWVAQERPESIHSAARLKILELYALHVLPTNGEWSEAKAFIDHSDALDEEQREAFKLALEQVREEMLLTEQKERELVQRREREMEAELQKAAEMAKIQQPKQPAKRSPLQKKSPQHQPPPEKQKSRSVAPPSGLSTRLSVLLKEVLPASLSSTRLAVFVIALLCLLARRDLRFRLRAALEAAWLKVRRTAGMATKVTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C745</accession>
    <name>A0A6A7C745_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_268442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C745"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19717" checksum="C8C629938BC4F312" modified="2020-06-17" version="1">MAQHGTSSGYPIAVLNHDIIDRLPAQSPILFAAKKEKNLSFETIANALGRSEVAVAAIFYGQAKASPEDVTNLAKVLEIPEEELLQTEITGWPDRGRQVEMPPREPLMYRLWEIVQNYGYAYKAVINEKFGDGIMSAITFSTKVEKEVDDKGEWVKITLRGKWQVLPLCHKLQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C794</accession>
    <name>A0A6A7C794_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_139735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C794"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="19234" checksum="4C64E78B5975343B" modified="2020-06-17" version="1">MLDGTADPETRDYRRCRPPRKRILGGYSICLCRQVSLMCFKYLSRGGPTISEICRLWVSSDRIPTQHSWMVQVAIPRRYTTGSVCYPFGNIIVVPVILKSLLTLLSLEKPTEPTERYVMESRQASGTRNSSRLYASHPALLDGTGCGTRGRASGSASYPSGRNVLLGCRELLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7P0</accession>
    <name>A0A6A7C7P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_196971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7P0"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="264" mass="28520" checksum="3C9F49864CBCC15C" modified="2020-06-17" version="1" fragment="single">AFVLSAAAAVSAADCNPTKASCPAIAGFTGPYSVDFSNNKALSSSDWIVAAYEDPFVKPSAQGLQFQLTNYTDAPNIWTSKYFLYGTVSVVMKSAPGKGVISSAVLMSDTLDEIDWEFSGNNFGKNVPTVQTNYYGKGIVGSYDRGTLPTVNGEMTTAFKNYTLVWKADSLTWMIDNKVVRTLKRSDTGDREHQYPQTPARFHLGAWDGGSPTSPDGTATWAGGRTDIHGFPYSSYVRSVSIIPDKHCAQYSYSDKSGSEGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C824</accession>
    <name>A0A6A7C824_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C824"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="425" mass="47039" checksum="6C81E45208D69A76" modified="2020-06-17" version="1">MAQHEDAESRPLDGHSLGGDDVESIDPVAFPSGSNGKRKRGETVCGPSTAKSKMKLELPEEEGTQDEESDYISELRSVGIQDFLKRHLWNLNELAQAFGLDPTTVDPGRLISAVRRAFYSRTKLPQYNTLDDAVSLLKSSHKILVITGAGISTSLGIPDFRSPGTGFYDRLQSMGMLEPEDVFDIETFDSDPSIFYRLASLLLPDQNRFTPTHSFLKLLQDQSRLLTNYTQNIDNLERLAGVSPACVVQCHGSFATATCRRCKQQVPGETIFPDIRAGKVSLCTQCPAPARKKRSQNDDDDSDEDVGPGVMKPDITFFGEKLSDSFFARFESGDVHDADLVLAIGTSLQVAPVSEMPGRMKPGIPHIYISREPVRHIDFDIQLLGDCDDIVQELAVRAGWREGQLTGKWEFAVDGESHVHRLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C877</accession>
    <name>A0A6A7C877_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_210001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C877"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="225"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="413" mass="44637" checksum="1658D7F5894255C7" modified="2020-06-17" version="1">MTSPLVSNFKLVEQSYPQAKDADNTAVKLSSAIFPNTDYNPQDVSEMEKFITTAHHIAAPSEDKLKTEERLSQLNTHLSTRTTLLGTKPSIADVALYERLAPVAKGWTDEEKTGEKGLHNVVRWLDFVQSAPLFGLRVNEDEKVPVDPERVVAYIKPVNQKAEKERKKMEKEKEKEKAMAGGATAAAGGAAAAAAGAATNKPDSKPKEKKPKPPKPSPAAERPLSPALIDLRVGHILKAVRHPDADSLYVSTIACGDAPGTPHTSEYEGQIVRTVCSGLNGLVPLEEMQNRKIVAVCNLKPVKMRGVVSAAMVLAASPRGEDEKVVELVIPPEDAPAGEKVFFEGWEGKPEAQLNPKKKVWESCQVGFTTTEERVVGFETQAVEGIEGGRGVAELRTKQGVCRVKSLVGASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="10802" checksum="8FE9F4A05FFA7C36" modified="2020-06-17" version="1">MPSGHDFRHRLDFHNCSSNLDGKYYKIIAKGSTNDIDKKVSVTCTRPSGGNGGQGGQQGNHCHYPNADECSNPNGSTDDNDKKGSVTHTPPSGGNGERGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8K3</accession>
    <name>A0A6A7C8K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_82354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="272" mass="29750" checksum="F69A4F4D2AC84133" modified="2020-06-17" version="1">MTSDKDSRRPRLRGLFSNKKDKKQSSASRGPGDRRPVDSAHGSNNIPGLISADDSRTNSDAIRKLSVTDTSVDSDAGTSDGRQRVMSSATSGSSLLRQPTLSDTMDDTTDLTWSQSSTTQDLVDNRGQTSPTQTNFSYPHRGDARFARSTSSVARPTTAYNGSRRNTLEKEALPANNKSIGAVAASQCSGRSMEGKPDRQNTVRLHDNLRAVRYPPRPQQQYPWAQSHAPPDPLYHPSYIEGPAKPYGTPGTEQDPKGSRRSFSGKQRKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8X3</accession>
    <name>A0A6A7C8X3_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8X3"/>
    <dbReference type="OrthoDB" id="5399183at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="470" mass="50839" checksum="888970F0F54AACFF" modified="2020-06-17" version="1">MASAPVHQDHYRFNFAQATTGTGIANKKVGVDQSDNSSVDSEHDDNAGEEEADASALSGADQDWNLAGLSPNVFGSFEDGLGLHGLEEPVLDCRMLEPHLRAEFVALERQQSDGYTGANFDGDFGDFMMGPHLNPINDSAPSKEFRLEDMIHTGALYDDDTGDDELQGQEDRAPLEPFPLHGEVQEFLPHLIDAPFTGYIHDSDLGECESDDGTPGAPMVAEANLAGGNTTEDEDEVDRWARCGDLVKGEAQPTGVDSKLARPKSVQRRSAVVEPARMSFEAGVSRGIVSSQYGDDFIALKPPSSPSNEQASFWHQQCGSNSCVASPNSRVTYAIVTPSRDFRDRPFTAQSTLSTSFDSHPAAFGIVSSRRASDPCRGGLFGSPQPGMAASPSPLPFTDTLMQILDVPSTECADDHADDVEGSMAHLVNRPDLLLAFSRNQHRVTQRSSMPSSPIGANSRRRRTRRPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C963</accession>
    <name>A0A6A7C963_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C963"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="BAC60DAD1569370B" modified="2020-06-17" version="1">MAQPDSNSFTSLSRRAWPYWNMQFADGPKSDEHLVVYDTSSDVCAPTVDGFSHVPADYLSIWCRSPVLSAISVTTYVEAQVRTILVRCQFSQLSTTFLIHVTSQRPTTCACSRDGLTKVAHATMSTPTCRSDMLASKVVRVGSVVSSKDCRDFRVLLRLLLRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P8</accession>
    <name>A0A6A7C9P8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:myosin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
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        <property type="entry name" value="Vezatin"/>
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    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vezatin"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="129"/>
            <end position="150"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="142"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="431"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863368.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="577" mass="64390" checksum="695D84EAE2FC4620" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA80</accession>
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    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_polI_A34"/>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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        <location>
            <begin position="286"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33554" checksum="0F85603B5C888AB8" modified="2020-06-17" version="1">MAEKKFKSEETVSSSEESEREDGARDGSAESESAQSASEASDAESKSDAESDVEPGADAESSSSNSNSDSKPKSKNETKNDDNSNPPTTTTPQKYSPPQGYSLSTHTQPPLPDPESEIYILTAPSSLPLSELTAHLKLPAPQKLKHNGREYNLHSREIQSTVLFPLEGGRYGEGRTVKGGLRIEESVQLVGRKDLGSAAAASVAEPAVERSREQPRGLKMRWRPPGTGEGKRGWESEQEEEEEKEEEEEKREEGLQFPSALGGCNTELEGKKNKTKKREKHGEKHEKKRKHKDDKDSRKIRKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAM2</accession>
    <name>A0A6A7CAM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">K470DRAFT_254100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="527" mass="59839" checksum="0FEE948C3324FCFD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB36</accession>
    <name>A0A6A7CB36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumble-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_210060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB36"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="432" mass="47362" checksum="FA3D0B7974FA165D" modified="2020-06-17" version="1">MEPPASKRRRISSSAADIEVQFARPGSIKINSTGAHIADHEDSDGEPVPGEEPDHSFQQDIRLPNQTEVVSHVAVDIGGSLAKVVYFTHSDAEPGGRLHFISFETNLIDQCIEFLRALQKRHRKASRSNSDLSIQATGGGAYKFYDRIRDTLGIELQREDEMECLIIGLDFFITQIPLEVFTFNDSDPANAVEYQPSKAGVYPYLLVNIGSGVSMIKVSGPSSYQRIGGTSLGGGTFWGLLSLLTGARTFDEMLAMAEKGDNSSVDLLVGDIYGKGMGYEKIGLGERTIASSFGKVLQRKRNAEQRAEDGGGLENGSEERASAAPGSDGRMFPPEDLSRSLLYAISNNIGQVAYLQSEKHDLARIYFGGSFIRGHRQTIHTLSFAIKFWSKGSKQAYFLRHEGYLGAVGAFLKRRPVHWVSAIPENSIDDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB75</accession>
    <name>A0A6A7CB75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_267309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB75"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="779" mass="84907" checksum="53D4A7A56BF8B59E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNK1</accession>
    <name>A0A6A7BNK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_191393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006086">
        <property type="protein sequence ID" value="KAF2857040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNK1"/>
    <dbReference type="OrthoDB" id="5039078at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9932" checksum="9CFCE279BB4149FB" modified="2020-06-17" version="1" fragment="single">RLGHVGTTILSRTKHVAVGLEGLDLSELAHCEPCHLGKAQRVVSRKPRPIPKTPLDEIHVDTVGPVEHDMLQQHRWIFILTDANSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNZ1</accession>
    <name>A0A6A7BNZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_20032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="MU006070">
        <property type="protein sequence ID" value="KAF2857083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNZ1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="98" mass="10333" checksum="8F8675DAE7025093" modified="2020-06-17" version="1" fragment="single">MAPGAIEKTEQAIGATLNATAATFKPAASHVHTESSQAAIETEAAHAAHNYHPLPIVFARASGCSVWDPEGKHYLDFLSAYSAVNQGHCHPKLVKALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP83</accession>
    <name>A0A6A7BP83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006060">
        <property type="protein sequence ID" value="KAF2857186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP83"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="291" mass="30796" checksum="38264D3D5B698E17" modified="2020-06-17" version="1">MIELAGLDEFADLSACISDGPLPWIIVAEGTRLVVGGLGQRDRRGERTAALALIPLLHVRGDQAIALRNAAAKSVSSRRDAEGLAVDRGDPAGERCQVGQGVPFDAEGVGTDPDREHAREPFNHGDEPLRAMDDASAHASDADNGARQEHALDRLEAADVVVGRSALQDRHEAIPDTKVSSAGETLVVGRNRTGDPVENLFAVRRDAVLAAIVDRGHAPERVRGGKRHVVGYRPRQTAVAHHHRVTGAVEVEADEAVGVVEGSRAPPRPFAPAIGLAPARQAVGGDQHRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ44</accession>
    <name>A0A6A7BQ44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_279431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ44"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="581"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="671" mass="74678" checksum="8E0E9E56D3BDB647" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ53</accession>
    <name>A0A6A7BQ53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_172978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MU006045">
        <property type="protein sequence ID" value="KAF2857413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ53"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="371" mass="40412" checksum="09DB298ADEF1932E" modified="2020-06-17" version="1">MSEFFLPNSHIGDRDQVEDWRIRGLTPLTPPDLLQHEIRHSDAAAATVIRGRKEAVDIVQGRDPQQRLLVVVGPCSIHDADAAREYCQRLLKLKEQYKDNLLIVMRAYLEKPRTTIGWKGLVNDPDMDGTFNINKGLRVARGLFRNLTEAGMPLASEMLDPISPQFLADFLSVGAVGARTTESQVHRELASGLSFPVGFKNGTDGTLGVAIDAIGAVRHPHHFLSVTKPGNVAIVGTVGNEDCFVILRGGSKSTNYDAKSISAAKEALNAKSLRAAVMVDCSHGNSEKDHRKQAKVASSLAEQISKREDGIMGVMIESNINEGAQKIPAEGKKALKYGVSVTDACIGWEETERVLAMLAEGVKARREKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRD2</accession>
    <name>A0A6A7BRD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_273017</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRD2"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2857764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="512" mass="58891" checksum="9771C463E84090A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRF8</accession>
    <name>A0A6A7BRF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_261132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006068">
        <property type="protein sequence ID" value="KAF2857098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRF8"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="97"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="360" mass="40134" checksum="43E0467D456CA7FA" modified="2020-06-17" version="1">MASFRLYRPIMVQNKGLFYKAHPSGMPVLGKDLVLETHEFDENQTPPSGGITAKINYVSFDPYQRGRMRPAEVKSYTPAFKLNEPITNDAIITVLKSDNDKFKPGQTLHTDSANTEEYIVMDKKAADACRVLNNPYNLDPKMFLGPLGMPGLTAYSSFYEIGQPVKGETVFISAASGAVGQIVGQLAKHRGLKVIGSVGDDKKLEFITKDLKFDGGFNYKKEKPLDALRRLAPQGIDIYFENVGGEQLEAALTQMNDHGRIIACGMISQYNKPPDQQYGIKNLMYVVSKRIRLQGFIVFDPNFGPKYFQEHQKNVQEWLHDGTFKAQLCVTQGIDHAGQGLLDIFEGKNFGKAILEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRP7</accession>
    <name>A0A6A7BRP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_192949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRP7"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9547" checksum="0FCB45F2F9F71DD6" modified="2020-06-17" version="1" fragment="single">HPSPSCLACGRIFPATHILDLHIREHHDPFVSLQRARGEKVYRCFVEGCEKVCRDGRRRRLHCIDKHGYPWGWGWGVVDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX5</accession>
    <name>A0A6A7BRX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_253566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRX5"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35981" checksum="E7A5AD163EBBF46A" modified="2020-06-17" version="1">MELFSLAPTPTSTHRYTLPLSPSWTIGSVPHGGYITSVLLSVAKLHFATTLSSCNQPDTLSVQLSFLRRTQTGPATVTVQDLKLGRQSSVIYVSLEQEGREEVVGFITQTDFGREEGVGFGMDWGIYPPPPVVTGSFGEMDRGRDANWGERKVWPLHRFRPAMGMMRSWFPRGGQLGKGIVDQWVCPRDDDKRWTTDCLGFIVDAFPQIVESLEFGGDLYGVELEERYTQEEQQEMMDKKGAGRKWYPTVSLNMEVKKRLPEEGVRFLFVRVQCKVMQNGRYDLEVIVKDMEGDVVALSNHVVLAVPAERNTAKRRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX9</accession>
    <name>A0A6A7BRX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein-like protein NOP52 variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_283519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRX9"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="230" mass="27003" checksum="76BF64C4D1196CF8" modified="2020-06-17" version="1">MATETGPSDTTFIKQLTSSDRQCRDRALEALRAFLHHHKEPFTTTDFLKLWKGLYWSLWLQDKPRNQQQLARHIASLADELPDRAQQRRFFEAFWLTMARVWSSIDSHRINKFMYLVRLSLGKVWECCVQSEWDVAWTDMLQAGPLDAQDASVPDGLRFHLVDIYVDELCKADEKRQSPLNEALRPLRKLCMETSNKALRRRAQEALQDERLAEWPSEIEDDGEEFEGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS31</accession>
    <name>A0A6A7BS31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_222818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS31"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2857717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="36921" checksum="0AF149C1E8377A8B" modified="2020-06-17" version="1">MENYQKMEKIGEGTYGVVYKARDLTTPDHRIVALKKIRLEAEDEGVPSTAIREISLLKEMNNPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPESQGGRGKPLPEGIKRKGHMGLGPDMVKKFTFQLVQGIRYCHAHRILHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMATRKPLFPGDSEIDEIFKIFRLLGTPTEADWPGVTSFPDFKSSFPKWERKGDEEIVNRDAIKVLGTEGLELLDRLLVYDPASRISAKQALYHPYFQDVPGVGEFTNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS32</accession>
    <name>A0A6A7BS32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_290290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS32"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="15940" checksum="71CC76E9220F7B3A" modified="2020-06-17" version="1">MACPDQHKRTPTVPRNSESVSQLYPPTRHQGGPILRTYRQGGFPLDDNGMGSPATSPHGSLRIGTSHQHPTTPLNMPFCKKKMRSPSTSTSLNGYQQMWCGCRTESMLLTLVAFLPSQADSIEMSSSCYDRPFQMDQLKQPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS33</accession>
    <name>A0A6A7BS33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_266350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2858041.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="573" mass="61015" checksum="B1881548C830DAD4" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
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    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="486" mass="53149" checksum="7B5B738153DA8487" modified="2020-06-17" version="1">MSSVYVIDSSARRTTVKVTPGTFVRTILEEACTTRRLNPEKYALKWNHKALDLAQPFRLSGLMPGAKIDLVLASKSPGVVSVALQVEGEGERVVDRFGSNVTLWVLLRKFEDGVAGNAGKMNLTQRGRKVNGRVVYEEPELNVGGRRLQGFEDLQKTLAQLGFNGGSVLVRLRFRTTERALDEVMGDISAYFAGIEGAGGDDGRRETGHEREAALKEEVGLQAGGIQAATPKTSSPQAASPQAASHQAASPQGILPATAPNDVPVDEIKVYRPPPGTTPAAVLQKLPEPEAEPTIDHLRGYQASLKQQGLNKRLPSEPELAERENTRKQKLDSIRSVTVQIRYPDQSRVERNITQSDTPKTLYESVAATLAAGPEEPFELSYYNAKGRKEILPRDSAATLIRSYDFVDRVLVTMSWLGTTSSKIRTGSSLKAHLLAKAEDLKVDLPVEDHQPSHSQIDTPKPAEPTKPHVNAEEKMKKFLGLGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSF2</accession>
    <name>A0A6A7BSF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSF2"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025448128" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="13929" checksum="933A0A4FDCFB10F6" modified="2020-06-17" version="1">MMNFLMLLLLPAMAMAATVQLNNHCSSSIYVTIANASGTAVPGELKSGQAFLTPFTGLGNSFGITTTQDAYWSPTGEKLILGASVDGGSIYWTLSSVNKSPVTPYQVTGCGGTKEANGVVRTCGEGEGIVLEVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSR4</accession>
    <name>A0A6A7BSR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_221849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSR4"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="146" mass="16808" checksum="F710F629198C573B" modified="2020-06-17" version="1">MAYFYYTLTFFFMLTATVLYVTRDKWKPYAPPIPYLTAPGTIPEPLFRTSEYFNSFRYVRLPTSATFAEDAEAGLHSSTFNLAENIGDGDSRSGLDMHSKQQVYRIMKLRGVNFDEARRIFVEERFGREGIGADGRPLDRKAIMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSX2</accession>
    <name>A0A6A7BSX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_162743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSX2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="16374" checksum="DD78CFDC5388F7C1" modified="2020-06-17" version="1">MPCYCRPVGTCSCCHVPLGCRSPPKPVMGHKYPSPGASRSRAIARRHPGAWLQLDMPVLDRGAFRRPIRFGYNTSRLDRVNNGPIGGVGNGHTVRSVVGVAAFVQKINHVVLLHQICILERGLNDKHAILDKDILVGVGVHSNWPFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSZ9</accession>
    <name>A0A6A7BSZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSZ9"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="51597" checksum="95E05BF1126974CA" modified="2020-06-17" version="1">MDTLQDTDWDLVISGTGVPQSLLALALSRRGLRILHLDRNPYYGQNEAALTLNEAQEWAQRHTCDNFSPFTQASVSTPATDGKLGSSRAYALALAPQFVYSWSQLVPALISSQTHNHLEFQAVGSWFTLPKSGSSLLHVPNGREDIFQDESLNLRTKRSLVKFLRYVADYEGQGDWSEKKGRSFVEELSESFGLSDVSYSPLLALALSSEPAHDTTFGSIIPKIACHIRSMGAFGAGFAAVMPKWGGLAELAQVACRACAVGGGVYVLNRGIESATQLSTGQLSLELAGGDRVTTKWLVGSSADMPQELQPQGETISTADYAKSICIVSSPLPTLFPPTSDGVVPAGAVVYVETERAPVRILAHSGEAGECPSTQCVLYASTLAEDGFEVLEQAVQWLLASLNEQAEVLWKVQYRHCGATLAAPTFGDGVCLLPTVSPDVTFDDKVLDQVKAAWLRVSGEDEEMFMQLEARQDNVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTC6</accession>
    <name>A0A6A7BTC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTC6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8157" checksum="912CA1221B4E5AD1" modified="2020-06-17" version="1">MRPLTTSQRVPFRGRPTSSFRKANITDDLQPAPATTDGAGSGSRTALATKNAWQAVFTNQYTWTFTLGGIKRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF5</accession>
    <name>A0A6A7BTF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_300986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF5"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="80"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="310" mass="34207" checksum="CC955829C531400C" modified="2020-06-17" version="1">MKLLLSTSNILTAGSPVHRTKSGSNTEFVDFLQANFVSRAEAIVETGNGLNDNQIYQKWTRHKGDVLEIPALDLTSSGLREASENYDITVKLFYLPDVSLAQREVHTRDALQLVLRELHVSSVNLLIVSFSGVFFDEGEDCPGKLSTRGPVEAQAEPIEVQIETWRVLESLHDEGLVKKLGIAELGHDRLLEFLQRTRIPPAVDQINLRYCCSVPPSLMNLAKSRNVELLVHNDTSNILPRGTVRELLGPSGANILAEHDQGDAHGHRTANAGMKGEVLPLWVVKYTAVVSNRGVVENKGYFAEAELLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTG2</accession>
    <name>A0A6A7BTG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTG2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="336" mass="37884" checksum="E6834481D1A61CA2" modified="2020-06-17" version="1">MCGDEAAIARSMLQITYPMENGIVKRWDDMQHLWDYTFFDKMGVDTQGRKILLTEPPMNPLKNRESMCEVMFERYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESTVLNHLTRRLDVAGRDVTRNLISLLLRRGYALNRTADFETVRAIKEKLCYVSYDLALDQKLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVEQPGIAEFLFNTIQAADVDIRSSLYRAIVLSGGSSMYPGLPSRMEKEIKQLWLTKVLGGNPERLGKFKVRIEDPPLRRHMVFLGGAVLANIMADKPDMWVSKQEWEEQGARSLEKLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU9</accession>
    <name>A0A6A7BTU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_127284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTU9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="25544" checksum="33CF6FCB55AFD24D" modified="2020-06-17" version="1">MRRPVTGVSTGFGPAWQTWAVFGQRASASTFTDIIISVVRNKKFVLTRCMRNLSRGVGAQQLIDSRCNYCTFPCPFYTVAKASLPKMPRQQHVFAPLSRMESRRAKQIIIWGAETAFYTCWCMAVELRSGCRLQRRAIYEEQTMEDISEGEIGTSILVEVVLVRGKGRDSKVGMKANVRVIISMESGRSISSTPYSMHEVRWEEARSRAGTKSNYDWRSKHLGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUB8</accession>
    <name>A0A6A7BUB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_220802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="13"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="628" mass="69553" checksum="A918259DDBCB1939" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUN3</accession>
    <name>A0A6A7BUN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_251722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUN3"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="492" mass="54390" checksum="F6149D2017E5CC2E" modified="2020-06-17" version="1">MSMTITPALVPIVMNGQKRRSARLSGEVADGTEPPPKKSRGNSGETNATSTTKPSQERRKAKVYDEDVDGFTFSKKRTRSRKAPEPAAAQTGKDVPETGPAKQADCSDQPGSQQAKEKAPRKARRTLPPTPEREIPVRRSKRLSSDKMQSQVAPSRQPSVQNPSPLQKVVSTQFHRDQTPPPLTVGKRRKQDADGPKKATRIALHFDETPVARRNGGVGKSSAENRRSSTDMRGRRASSLMEEGKGNGLPHPEVPTAEFYQHISPGLTEPRRMRCLLGWCGTRALPPRSEENSGPETRARQTAFAIQEELSKELISNGRLSDWFSRDEVPRPVRRKKAHPRNIANAANAEKLGRELERLKRERTEWDEIVKAATIPSLGDIGKEELSSPIEPNLLIGPYKTSIGRIQPMSEETLASTARRLRERRSELQLQVDSYANGGHIVAMTRGKAQQAADDILSGAAEHLDAKDRRAQAKALEPYDVLRALGKVINAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUZ7</accession>
    <name>A0A6A7BUZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_271920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUZ7"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="231"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="571" mass="63651" checksum="1B5AFF4D4E5F5B7C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV56</accession>
    <name>A0A6A7BV56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_278427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV56"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="338" mass="36132" checksum="B836E286A06B5E71" modified="2020-06-17" version="1">MVTTQSMPRVPFATLGSSRLGRLSSVKNCQNGEVLKASTGKAGLGKASLKTPVNTTKLAPVNPAVDSLKSSGKRSFDFSIFEDVDSENLDPETVASPAKKSKITSSAFTFSLSSNSNTSNTMAPPPVPKRILTPMSPRKPSTAPAGRSPKGSRRLSKGIKSINPPFGIQDTSLPFSLDEALRGALDPRPAPGTASAEPAPTTKPSYSIPEKEPMSKSLIFEIYQDSPSEEAANLMEHGTLTLDLSDDQGSKIGLGKENTPPPDYDAVRASQPHVPAPRRHRAPLSPEVMDDGQRTPLGELDVPSSGDDELEPEGKKVDAIETKEKKLETVEEFTIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF9</accession>
    <name>A0A6A7BVF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_259529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVF9"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="288"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="368"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="504" mass="54626" checksum="34C78C3D2BB63A76" modified="2020-06-17" version="1">MAFSKSQRILLLLVINLIFFLVEIIVGYMVHSLALVADAFHMLNDVLSLAVGLWAVRIAGSTKNSKTFTYGWQRAETLGALVNGVFLVALCVTIFLDAMQRFFEPQEVSNPKLVLIVGCIGLTFNILGLFLFHDHSHGHGHDHGHSHSHDAVKNAEEGHHSHGPDAAVADESGNVADVLPQTRVAGLSKPAVEEERPTSARRKTRRTSALDEIYVNPNAFRQSIIEASRASFDDSEAVEATGEGQDANQGTRTDDPLLNKVGKKASYGTLQPVDHSSHQHTHPRPAAKGHGHSHGDLNMRGIFLHVMGDALGNLGVIATALIIWLCHGKWRFYFDPAVSLVITIIILTSAIPLCRAAARILLQAMPAGLSVDDIKDDIASLPGIISCHHLHVWQLSDSKLVASLHVQISFDFKGAGSARYMQLAHEIRKCLHEYGIHSSTIQPEFCLDPQHNHSQQQLQVDGPGDTETAPSSKTPSVCEGVCLLDCSDNCSKAGQTCCAPAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWC4</accession>
    <name>A0A6A7BWC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_258848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64833" checksum="331046EB366725EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX05</accession>
    <name>A0A6A7BX05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_205954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX05"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="335" mass="36846" checksum="7DBA5600F6CECF79" modified="2020-06-17" version="1" fragment="single">SNFFREARFSSDGTSIVTHNEDQTLRTFVLPTDLLQHEEQHLNVYSNIFSPSPIQSFSLYPFFNLSDVSTTVVLVASKDQPIVLRNALHYETLHASYSFIHPQRETYMLSYSLAFSSDGQSFVAGSKNEIAAFDLSRSGEGPVTVLKTAGGRRERKFQGMRCQGPVSALSFGPDGLLAAGTFEREVGLYSNGEFVTAFALPHGEGTGVTCLKWSPFGTHLIVAERQSDVLQVYDVRNTMHRVCTLRGREAFTTQRLGFDIRSVPDGYQIWAGGTDGMVRIWDKPGSKADACPPNGEFNMHSSSVSSTLWHPSCAVLATCSGQRLKHDPSGDGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXK5</accession>
    <name>A0A6A7BXK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_90780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXK5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26160" checksum="27A1D7125AEC013C" modified="2020-06-17" version="1">MTAKDLYIPASYCHVLFFFHMSGSRSSVFMRHPTEQYIHSRRFSTVIHPDNFQRTLQSPGGLGTDYNTSMTTSRIINEAKNCERQEKKRRRNRLAQRKSRQLCKAKIAEGERNKDHVQKLQPALKACVKKLIQHHVNLDQQTLWTTPTHGHAEMLLQLPAQPSSVFQMEEVLAGITALWATEADVTDLEFLLAAGGFNVDHNSPPHLPSADYTAEDFTNGHMTHSDTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY02</accession>
    <name>A0A6A7BY02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY02"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="84"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="22954" checksum="1203E0FBD8E9FD81" modified="2020-06-17" version="1">MSSEDIMGSGETGRPSGNASSTEKNLSGLKTSLRGGLRQFPDFPSKGVLFEDIMPIFANHELHNSLIRALELQVAQAFNVVTGGKDKVDVVVGLESRGFLFGPTLALRLGAGFVPVRKKGKLPGECATVTFKKEYGEDVFQMQSDSIKRNQNVIIVDDIIATGGSAAAAGELVRNLGGNLMGFIFLMELDFLKGRDKLDAPVYTLLSGQEEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYA0</accession>
    <name>A0A6A7BYA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_233249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYA0"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
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        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022664"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2859967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="51254" checksum="3FD72F176F23C5BD" modified="2020-06-17" version="1">MLCAISGETPEHPVASRKSGNVFERRLIEAYIAENGTDPVNGEELSVNDLLDLKQSRLVHPRPPQLTSIPALLSTFQNEWDAATLEAFQLKQQLAQARQELSTALYYNDAAQRVIARLQKERDEARDALARVSLTPAAVGAEADGEPMQLDGQGLAPAVLSHIDEVQQKLSSTRRKRPVPNDWATGNKIQHYQVKSTADSQFTGAKFLAAHHTGDFFLCGDSDGTIGVYDLPAQTFTTRCSLGSGAVLDGTWAHNKAVVATESGAIVVTQDGAVQAKLHQHAGPAVAVATHPGGEIVASIGADQSYVLYNIHDSKTLTQTFCGEILTTVAFHPDGHLIAVGTASGSIKLYDVKTAQLAHTFPASTPAPIASLSFSENGTWLASAVSGQALITIWDLRKLSTLKSLDAGFEINTISWDYTGQFLLVSGPAGIVVIQYNKSLKKWSEPLRNDFLSVDAKWGSKAESLIALSTEGIVNVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYA2</accession>
    <name>A0A6A7BYA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYA2"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="421"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="530"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="677"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="838" mass="92287" checksum="A385004DB3996793" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE5</accession>
    <name>A0A6A7BYE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_271003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE5"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="28252" checksum="755F571F36A620F1" modified="2020-06-17" version="1">MEFYPARFFTASKSYNEWNRLSIKDVITLRTLAGLGFQQVYYYLNHPIQYVRVVGVVVDIEQFCEGKFTVLTIEDGSGESIEVRITARQGDDFAAPSNTTVDNVNAYVHLGLPLVKLNGCDVVVGSVVKVKATIRVFRKQKQLELKRLFFVNDTAAEMKAWEETAAWKRDVLGKPWKLTREEMREVDDKLRIEDERRFEKRKKTARYEQKLKERGLKKEQKRAAQEREFDAGALPGSSRLPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE9</accession>
    <name>A0A6A7BYE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_217152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE9"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="101" mass="10876" checksum="AAD3284F0C79992C" modified="2020-06-17" version="1" fragment="single">SRSDRAGVIFPVGHVQRNLRKVTCCRIHRAAPVFLAAVLQYLVAEVLEIARNNASLRGFSTLRTQHIPAALGSVDFSELVRNVTFARGGQSSGAFAADALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM0</accession>
    <name>A0A6A7BYM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_295053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025637170" evidence="1">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="279" mass="31895" checksum="663FCA083EA2D0B7" modified="2020-06-17" version="1">MFKILIYTLFTAIAVAVPLRLAPEVVGRAPLTLNISAADPSAGHLKRRHANDLLAQCMHDRSLKLRRIEHSQDFDDFVERAVESHIAPLMAMTKKFDKTRERTDYLQELTQWISKAEEVFADIVARTKDGIVAISEMQYAGEKLVAQNIERIWGNKPQDYCQKLLDLYLTVPKLEPIYRELINRLTPLPSRASQQLTFYLDDIAVAHKMPENLKGINKRLSKDFRADIMRPRKSARTILKHVDKTIKMIAATTDRATYADAVAGKRNLKDLKKDPFKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYN8</accession>
    <name>A0A6A7BYN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_70453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYN8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025524551" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20725" checksum="58669FA0F905E6BF" modified="2020-06-17" version="1">MKKILPRIVFIVISPIVVATCQQKHSIALYSLKIVEKGHRDNQHNSGFHQEPQRGLAPMVALVGPVTPFADARDHGVPIGQVPFDYHIGNPHAHYPPSDGKLIFSSCTRIDNNFHMSLLRPATMRSPGQQSTCPRQVHILLSGWNSKHQLSSPIIFFAEKVTTYLHGSTKCKSPTLAIDHGPRPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYP7</accession>
    <name>A0A6A7BYP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_218378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </source>
    </evidence>
    <sequence length="320" mass="29678" checksum="FA62CF80453DE420" modified="2020-06-17" version="1">MASFIPGSGYIASCIHLPHYNPGGNTVNSSVPISGQAPVSSVTGSSTSSPAGSSSPASGGSTTAASVSSPSSLSASGVPSSVAPTSSVTAGSSSAPVSFAASGSASSSGAVLSSALPGSSLPAGHNSSSLSASFEGKSSGSDIGSTASPSGFIFSGSVSASRSVIITGALTSFISASATESSSGSVPSGSVSASIPSSNSASSDSASATGSAPGSGISGPTSATGSTSGSVVSGSTLSTLTLGSTATLPSGSAFPRFTTLTGSPGSATSGSTPLASVINVTVCAATNAKATTVYARSTLTQCPTGVCSKSTATPSLVARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C146</accession>
    <name>A0A6A7C146_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_72303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C146"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="92" mass="9780" checksum="2D8DD96736AB8F8B" modified="2020-06-17" version="1">MRAVREAMYCAISSVCSAGWWSCDMINDILSVGRFSEVGVVKREKGKGSGRPRNPTSAAQSDVDNTTFGSTKNTSQGAAPNNTPPRGHDTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1C7</accession>
    <name>A0A6A7C1C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_281562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1C7"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="33130" checksum="AA52C968D7BD12C2" modified="2020-06-17" version="1">MFAYEAVKGFFWQDEPGTDPATFDHISSNFGLIERSYPETRHSDTRVTQWQRFYDYLEHLIASSPSNVTYKLIYMGRHGEGEHNVAEALYGTNAWDDYWSKLDGDGTLFWSDAHLTSVGQAQAREARAFMQKQIQTQKMPAPQSYYVSPLYRCLQTANLTFGGLELPADGQFRPVIKEMLREVLGVHTCDRRSSRTAILHDFPNWTFELGFQENDRLWRANHRETWDEHDARERALLSDIFTNDPNPVISFTAHSGTIASLLRVTKHRVFALPTGALIPVLVKAIKIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1J7</accession>
    <name>A0A6A7C1J7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_299571</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1J7"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="117"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2860815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="310" mass="33838" checksum="B3956B2C0BD27284" modified="2020-06-17" version="1">MLQGKKTVMGMPGFVVDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIRAGRLDRKYDGIMDCFRRTTADEGVLSLWRGNTANVIRYFPTQALNFAFRDTFKSMFGFKKERDGYWWWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSASKGGTRQFNGLVDVYRKTLASDGIAGLYRGFMPSVTGIIVYRGLYFGMYDSIKPVVLVGPLEGNFLASFLLGWTVTTGAGIASYPLDTIRRRMMMTSGEAVKYKSSIDAAQQIVAKEGVRSLFKGAGANILRGVAGAGVLSIYDQAQLLLFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q3</accession>
    <name>A0A6A7C1Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_245428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q3"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="56"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="3">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47184" checksum="CF117A05AC0C67E1" modified="2020-06-17" version="1" fragment="single">MSGVDVAHCVASLDAFKRADGQHQQQRDALLQQFEALLKEHQLLKILKTNSDASGDQKPFVMVAIDGDSYAFDDNLIGMGAEGGRQAATLLRDAVRKSIQKQGLDDCPIMVKVSANLARLSNRFDRMTGNNKGGRSVAAFAADFTRSNELFDFVHVGDSEGAAVFKTAGLVQHFLGIPQCRRIFFGGCTEPEYIPTITSNRGNLKKITLMNIPGSLPQYSQLGFETEDFSPIFTSASGPGSAQKPLPDVSQAWNALPQQVEAPQQQGYESDSSASDPGHPFTVDPNVRQRQTYNPLNDVSVLPSPDSIAPGQIPVNMNGWRLDPLFPTPSIQDTLAYKDFRANKTFCNSFLALGRCIDADCSLPHEPVPEGIANAHRQFLYSRPCQRKGRCRRQQCQFGHVCQNANCAFRGGRIYCKFSPLNHRDSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Z7</accession>
    <name>A0A6A7C1Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_216092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Z7"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025361213" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="255" mass="28284" checksum="488003307D5E682E" modified="2020-06-17" version="1" fragment="single">MFARTLLLASVLAGLAQSHSWVEEYQVIGPNGSYTGSRGFSRGYVARTDSTFNGFSMSYQIPSDESARIRLSSSDHVCHPAQRTSNYTNPDYPMLQVQPGSWVALKYLENGHVSLPWSQAGKPKAGGTVFVYGTTQPSEDDKMVDVLEWTADGSGGNGKGFLLAAQNFDDGRCYEMNCGNISLTRQVLYPNHVPGQPQSHIEQWCESNVQIPTSQPAGKLTTYWIWQWPTNPGMDCIYPHGKDEYYTTCADFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2F2</accession>
    <name>A0A6A7C2F2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_263944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2F2"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="571" mass="63540" checksum="1C99945EE9BFE8BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2G2</accession>
    <name>A0A6A7C2G2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_281486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Apc5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAPC5"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="7">
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            <begin position="240"/>
            <end position="334"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="395" mass="44801" checksum="E362629624B4D472" modified="2020-06-17" version="1">MPRYLTPERLCLAVIVQLYLDTKYPHDTQLAVLSFVASRILPVPQLAKLRIDELLDAKGIGAKVFARKLSQLPSNVSNRSVYDNFLAQIWGYSGLDSLQVLFQQLGTFVNPQTISGSLQLSGTGLSRASPIGQYIRRCVLEFMRLQFNDALDIWKDFAAFRGPTYGEWARKNGYVGSEPVSLPSTQSFASTWSAEDADVLLSLSIGQLQKVGTRLPIQVKLKLQDWIANQWQSGALSRQHLLAFFEHWKAGQYNMALESLHRYFDYSLVTKEGSEELRDHYQYALLHLSMLHAEFDAWEESIEAMGECIATARENHDTACLNYALSWLLYFRQTRALDSETTFKGMPELKGSGGNDEDEISFLKAKAKESRNWLLLASTLMDEARIEVYQHHQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2H8</accession>
    <name>A0A6A7C2H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_281744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chaperonin-containing T-complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chap_CCT_beta"/>
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        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="560" mass="60185" checksum="647708C5801B7473" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2I1</accession>
    <name>A0A6A7C2I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_197998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2I1"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="188" mass="21158" checksum="BC9D73B25A55DABA" modified="2020-06-17" version="1" fragment="single">DEVNIGLHPTHKLGRYVALDCEMVGAGPPPYRDHVLARVSLVNFHGEEIYDSYVQPPAGVVIGNYRTAVSGIEPHHLSADVARPFEEVRAQVAELIRQRILIGHGVRNDLSVLQLTHPWGCIRDTSLFRKFIRENGGKKPALRDLVRRELGLSIQNGEHCSIEDARATMLLYVKEKVAFEEDCRRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q1</accession>
    <name>A0A6A7C2Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">K470DRAFT_214953</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q1"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="395"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="575" mass="64476" checksum="A66EAA7D2CCAADC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3C1</accession>
    <name>A0A6A7C3C1_9PEZI</name>
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            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">K470DRAFT_256266</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 480.64</strain>
        </source>
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        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
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            <end position="152"/>
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        <source>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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</entry>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6251714at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="267" mass="28741" checksum="AC5B1FC68787ACF5" modified="2020-06-17" version="1">MSSSAASRLNGKTILITGASSGIGRAAAHEFAQTAPEHNLKLILTARRTSNLDEVSNSIKSSFPQVSVHTAQLDMTSSSAITSFLPSLPKEYQEIDILVNNAGTVRGVAPAGEVPEDHISSMIDTNVSGLIHMTQAVLPGMKSRNRGDIINIGSIAGREGYPGGSIYCASKAAVRAFTEAMRKELISTKVRVMEIDPGQVETEFSIVRFSGDEKKAKEVYKGVDPLTPEDIAETIVWVASRRENVVVADMLVFPNHQAAAQVLHRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3F5</accession>
    <name>A0A6A7C3F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_213876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
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        </location>
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            <end position="134"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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            <end position="1132"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
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            <end position="96"/>
        </location>
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            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131692" checksum="41E3DF8B437F2DE4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3F7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_256530</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="115"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="519"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861994.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="637" mass="72735" checksum="305D7F787C0850D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3K1</accession>
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        <submittedName>
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    </protein>
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        <name evidence="8" type="ORF">K470DRAFT_214164</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005970">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
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        <text evidence="1">Belongs to the calmodulin family.</text>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="EF-hand" evidence="6">
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    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
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            <end position="159"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862471.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="159" mass="18122" checksum="30060AA06C631BB2" modified="2020-06-17" version="1">MADSLTEEQVSEFKEAFSLFFPANTDSFSQDKDGDGQITTKELGTVMRSLGQNPSEAELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDTEEEIREAFKVFDRDNNGYISSAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Y5</accession>
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    </protein>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
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    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
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        <location>
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    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1305" mass="146079" checksum="F8AEEEEE8DA00BFA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C526</accession>
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        </lineage>
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    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1202"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="375"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1288" mass="144303" checksum="7B08D3705CDA17D6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C551</accession>
    <name>A0A6A7C551_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C578_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_262766</name>
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    <organism evidence="1 2">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C578"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18626" checksum="78252615EFD3CBA7" modified="2020-06-17" version="1">MIDAHWHSTFRKLYGLTWQARECKAYNRLSGLYGCLFGSFVRYTGHGAAVFRVKHFLRRSIGVALLEEWTESSLQTEEVFCGSEGYKLLTSAGHYTRSLIEDISDVLNVQHLCGHGCKVTWRTSARVVEGETSEGSLWTHDEEGSMKWILNSYMLSTRNAPAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5B7</accession>
    <name>A0A6A7C5B7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5B7"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="312" mass="36128" checksum="453498239B8119BF" modified="2020-06-17" version="1">MSLFSFSTPLDIDIVLTDTDERPTVDINDAKGRREKAPLYLDGETVSGIVTVRPKDGKRLEHTGIKVQFVGTIEMYFDRGTHHEFLSLQTELASPGELQHPVSLPFAFKNVEKAYESYSGINVKLRYFVRVTVSRRMADVVREKEIWVYSYRQPPEANHVIKMDVGLEDCLHIEFEYSKNKYHLKDVIVGRIYFLLVRLKIRHMELSIIRRESTGAPPNQYNESDTLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFRDVNKKFSVRYYLSLVLIDEDARRYFKQSEIVLFRQPPENSPLALEQATQIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M7</accession>
    <name>A0A6A7C5M7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_268696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M7"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="408" mass="45671" checksum="6A01BE66DB2D2C63" modified="2020-06-17" version="1">MANESHHRAVRSRQNSLAHARNITNTPVKPEEDWTKMTNLVERRRVQNRLAQRNYRKRKRLSECSVRRTELEPKSEGHVAMTPASSSPISPSYTLEAESTASSTLATSPLELTPYQQQLPSYCSLPINMNQSVGYFDYLPWSMDPATFTGVERTNSSERDVTSPLEWDAISPLECYPPMMNPPSYGNALMADLTPLGEDELCSAYGYYDKSHLTPHGTTARFWGTLDTKTLGGAGFASQYTTGHWDLEPYSAIEITIRPSTEGNGEGEEGSSTGGQKRLHTNEQPSPKPQSPSNPHQRNPTPLPNKGNSTNAHPRRFTFVIHDHPPSLRPDGRLKSQISWEGIFEPPPSGEGRVRLSFDSFRPFYRGREVEGMLDRGEIRRMGFMMRSYFGEQEGGFGVEMGGVRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T0</accession>
    <name>A0A6A7C5T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_212075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5T0"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
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        <location>
            <position position="171"/>
        </location>
        <ligand>
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            <label>1</label>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862844.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="383" mass="42290" checksum="2FEC3CC7DF99DE91" modified="2020-06-17" version="1">MKWWTAFIASLAVANEQDKGTSHKPDKDLDGKWGTDWAFSGISTFAHLPHMRCLQMPEVEYDIAILGVPFDTAVSYRPGARFGPRAIRAASARQTPSRAYNPRAGLNPYREWAKMVDCGDVPVTPFDNELALRQMTEAFTELSHRAAPGKSARSHAKYRQKSKLFTLGGDHSIALPTLRALNRVYGQVAVVHFDAHLDTWHPTKYPSVWVNTEEYEQSYFTHGTMFWLAYNESLLLPNKSVHAGLRTRLLGQGDNEEDDAQGWMRIASDEVDELGPATIAQRIVSHVGRETPVYLSVDIDVIDPGLAPGTGTPEPGGWTTRELIRVLRGIEDLNVVGADVVEVSPSYDGTGEATALAAAQVAYEILTSMVKRGLAGDEIRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T1</accession>
    <name>A0A6A7C5T1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="237" mass="27059" checksum="CB0B29ACF9DD25F0" modified="2020-06-17" version="1">MPPFRLPLRPSATQIQLTRLYSTPPPKPRVLAKPERFNPPSHPSRRRDPTSYDRPLGAQEKEMQKTRRYPHMMPPEGTFLHWFLTNRNIHLFISMSVLISLCVTLWVQDFLLNTPYRDLLPPKSMIFAHPIRFLGRWFEVYGMHVRYVSDQTAERRRRKLEDVEKRAAYRKAHGIETGGSFRTEDSSPLADDASPVAAHEPQAASGTAGQVQGSSQAEVTKPAAGVSQPARKWFGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C665_9PEZI</name>
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        </alternativeName>
    </protein>
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        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">K470DRAFT_293294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2160599at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="335" mass="36793" checksum="4A96A1271DFB64CC" modified="2020-06-17" version="1">MNAPAASVTTAKRCLRDDAERDEGPLAKRQRLHTFTPQSSPETKHQSPSQSVYMSWQAHNENSASFPTPPSTSGFAGQLNGSVHSNVNNGDVTMTDATLVQPHGDGDDDDDSKSDVPRLYRLRPEPPTLSSFHCLPQQDVLELYGLRSIQASVARFDADGNKINRLRKTYAGKVKDLDISGKFEPKKEAWELVGLIDPAWDTAPSGDKTLWQEQKLSQYPSMDLEGSSALLDKLGSALGGMVKGQLPAKEHKHWADQLGPERHLTIKPFTCVKQRASAPVSPRGPIARPNRVNKKRRYDESSYSGYADGFIDDEGGYTTAGDAKRHKTGGLARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6H9</accession>
    <name>A0A6A7C6H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_255752</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6H9"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Tubulin"/>
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    </dbReference>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="448" mass="49897" checksum="04DBF46B01287EB7" modified="2020-06-17" version="1">MREIVHLQTGQCGNQIGAAFWQNISGEHGLDGSGVYHGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLNNPTYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQVRNVQNKNNAYFVEWIPNNVQTALCSVPPRGLKMSSTFVGNSTSIQELFKRVGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVSDAEEEDYEDEAPIEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6R8</accession>
    <name>A0A6A7C6R8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="17989" checksum="0674F422CF1E2F91" modified="2020-06-17" version="1">MDDSTTFSPTSHKNDESDHIINILYPNTLVSSSASFENAHPSSQETVASTATSSFIVGTTFNPTSHNCQSNHLVSMPFLNTAISSSTSFENAHPSRQNVVACTAASTLHTGPSRYYQVNSTSVSGFNAAHSSQSARPLLPSSGTPAAFAQASSYHSMPSTESASGKNIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6R9</accession>
    <name>A0A6A7C6R9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6R9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="78" mass="8404" checksum="8B9FFA2F023060B6" modified="2020-06-17" version="1">MSKFSKVKPLYRLHLTHQAGCLAAALGALYPPELDSLWPFPDVTLSANGVPDALHGLSRLETLSITVQTGPCNEHIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C718</accession>
    <name>A0A6A7C718_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_211020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C718"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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</entry>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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            <end position="196"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="218" mass="24230" checksum="C496ED8300E32A26" modified="2020-06-17" version="1">MPALPQQGGSSSSTSTSNQQTQTQQQGAVPTTYIGSNSSPAPGAVAGIVLGSILAFLFLVWLFWQLTNSRNSGGTEEEELYVRRERSRSRSRSRSRPRRQHRRHHRHHRHRSPPRTERIVRQIRTVRDATAPAAVPVAAAAPPTPIMREASRTREATAYSVHETRVEGDDMVEVFEDESSVSGAPVPRRKTHRRSGGYRSVDPLQPGGGDYPRHSIRV</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="18">CBS 480.64</strain>
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        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7S2"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044216488" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="30832" checksum="33F2CCF503C881C9" modified="2020-06-17" version="1">MKLLQSAAVAALSLSACVGAIDTWSFEDAILSIQGKGSGVGGGLKEKYGTRKPLASSPISLPAGETVKVTLTTTEGKTGKKAHQAFLMLQDKETGLEDSYPFTLKENGKGKVEISLKDIPHQFVSSVKPLQASIVVASFGSSTPYKAPAFDLFVQADPGASPFEHSAPERYGQKPEIHHIFRADPKSPPRIISLFFTLAVLSTLPALIAVWLFLGANLDHASKAFTASPVAQGLFLGSIIAMEGVFFMYYTTWTLFQTLPVAAVVGTVAVISGSRALTEVQIRRFAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7V0</accession>
    <name>A0A6A7C7V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_255010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7V0"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="52"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="399" mass="43630" checksum="63F1F9AA82A51DEC" modified="2020-06-17" version="1">MYRAASLLSRTSRRQITTLAIETSCDDTSVALLTNDKSTTEVHFHKTLTSDNSAYGGIHPLVAQSSHQRLLAPLIREASLLLPKLPPLDMVAATRGPGMYSNLSVGLSIAKGLAVAWNVPLIGVHHMQAHALTPRLAASLQNKPTPSFPFMTLLVSGGHTLLLDTKNTVDHFLIAETKDIAIGDCLDKCARAILPSEALKSTVPYGRALEEFSALNSESYKPPKSRSEEITPRESEWDWALPPPLKSNRRLEFSFSGLLSSVERIVFTSNEISLRERRHLACEVQRVAFEHLLSRILIRLEAGVDTPKALVVSGGVAANKVLKTVLRRGLDVRGYANVELVFPPMELCGDNALMIAWTAVEMWELGFVSELGIEPFRKWPLDGMVAGGGVLGVDGWIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C870</accession>
    <name>A0A6A7C870_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MSTA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C870"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
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        <source>
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    <sequence length="511" mass="56207" checksum="54D622FD79FA1D40" modified="2020-06-17" version="1">MEVIEAPVGQLRSYVICVFAAFAGTLFGYDSGYINSVLGMTHFLRVYGHENPNDPGQFAISSAQHSLIVSILSAGTFLGSLFSGLLADGIGRRTSLIAGSIVFLIGVIIQLATLNIPGISIGRFVAGLGVGLVSSVNIMYLSEVAPRKIRGAIVSCYQFAITIGLLLANIVTYVTRNRDDSGAFRIPIAVQCLWAVILIIGLIGMPESPRFYVRKGRLDRALTALAQVRGQLHNSEPVMQELIEIQAHYDFEKSRSGRSFLGAPVDRSTIRKFILGCSLQMFQQWTGINYIFYYGTTFFQQIGLGAGNSYTYAFVVSMIMTAVNVGASPVSFYAIERFGRRPLLIYGAIGMMICQLVVASVGTASPKSSAAHYCLIVFVCFNIFFFASTWGPVAWVIVGEIFPLPIRSHGVAFSTASNWLWNFILALISPYMVDNPGNLKYKVFFIWGSLCACCAVFAYFHVPETKGLTLEQVDHMMEETSPRSSAGWGKRQDWTRNTSQEQIMVDMPNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8M9</accession>
    <name>A0A6A7C8M9_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="415" mass="46279" checksum="FA4C7BB88A58BE4D" modified="2020-06-17" version="1">MTVLSFFLIFSSPVALYLLVLKLLLIHKLQRFALYAHKFNTLFLGDNLASGESFGFLSRQVTPFIVSTHDGEKLFAWHILPLNSYIKHGPDILEEKTQGKDKFLEKKEFIRTKAFGYLTRAERVVVVFHGNAGHVAQSYRPGLYRSLINQANTHVLAFDYRGFGHSTGSPTESGLIADGISFVNFVLHVAGVPAERIILLGHSLGTGVASAVALYFADSKSQMVPTEAKPKPELKDDDGISPTTFAGVVLIAPFYNLPLLLLTYRIGGCLPILLPLRPIFPWVTKILNQKIVDRWRTADRLAMYYGILINNRKAMKTMGNSKLLGGVHLIHSRRDWDISFRQSEMICARILGADDKAWRKSCVDASRGPAFAEYIPDTDEDFVGPNWRVDIVEYGGHNKILTFAPVAAAVLRIFG</sequence>
</entry>
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    <accession>A0A6A7C922</accession>
    <name>A0A6A7C922_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OrsD"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="663" mass="74387" checksum="600A95D28C128A38" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C926</accession>
    <name>A0A6A7C926_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255187</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="26"/>
        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="62" mass="6017" checksum="E531F275E012ABCB" modified="2020-06-17" version="1">MSSLAILLGVLGTIAVIAAGLIFFVVQRSSGKGGGGGGGGGGGGGETTTESETVEYWVRSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Alpha-taxilin</fullName>
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    </protein>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <text evidence="1">Belongs to the taxilin family.</text>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863649.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40579" checksum="763D3E3A8ED2913A" modified="2020-06-17" version="1" fragment="single">ARSTAKQGKKAAAQSDPEMAHKALLSKISQLEASNTETANEAAEIESEVTKSMAEMISKMGPHTNRLEQVQQKYSDLLKEMKRMEREYTRTKKRGDQLQKEKEEAVKDRIKERGLKEKLEKLSRELTRENKRLKEEARDVREASVGMSAELHDRLEALVGDVDRVTNSRGASDPPPVELAADNKFAQHMESLVQQYEMREIQMQGEMRLKDLEIAFHQKRHEQLQRAQETELSKSSQLTRQVSTFSQTENELRGQLNVYVEKFKQVEDTLNNSNDLFLTFRKEMEEMSKKTKRLERENQTLNRKQEATNKNIYQMAEERAQNEAERAQLRVENEKLKSLCRAMQKNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C9I6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
    </feature>
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            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="19863" checksum="F89646487331D54B" modified="2020-06-17" version="1">MASPDENRGNHWTPPSEPSQTTSKANQSEQRKTSKWEALSRTQMAARRGPTQAALQDERRRKFFRQTREARDEKRQDARGEAMLRSEFVAAKKDYEKQMHEEANRIGQMHEEEQEMMDHDQEAEEMMSYEDAETAALAANAPSPLSSKRWSSGTDYSALFATIDDGEGEAMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA08</accession>
    <name>A0A6A7CA08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="23914" checksum="809DD2B3168D712E" modified="2020-06-17" version="1">MCHIYTPYYTACKHYGVQQFFYGAPCIRGATLPGCSRTGCDQKTDMGIETIPTPCPNCLKLRDQNQSLDARIGAWRRRESVEDDDNDNDEDEDEDDDDDDDDDDDDDDDDDDDISSECTSVCTQVIADGEKTLRTKEHCDDDNTLDEEDLRSLEKTTSKADSGTTISVTSGKGSSVQQGCTKSKKAFCRLPHAPSVSRQISSLQTKILRVVRPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA91</accession>
    <name>A0A6A7CA91_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3257981at2759"/>
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    </dbReference>
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        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025681974" evidence="1">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="52266" checksum="571774079B013DFE" modified="2020-06-17" version="1">MRVISSAAAVLAVAMAQVAVATDVFAHFMVQNAYAYDVNQWKQDMNDAKSIGIDGFALNWIPPNCQWGLAWTADRIDDAFEAAEQVGFSLMHSFDMSYSECDIYWNQTYMQDVLTKSASSKAAYKWNNNILVSTYGGDQVDQYGDDFFAGLKRNMAYSNMYITLAPALTKYSLAAQDDPTGSASKLMSDYKSIDGYLNWQAWPLNTGQNISTTPDQAFKNAIQSNHRSGPYIMAVSPWQYKDLNNGNPLDSWVAYSDTLYPTRFQSLVGNNAFQPDLIEILTWNDFCESHYLRDLPDQYDTSKKDYIQLGEMGAYVWGQDHSPWRIMTKYYLTWLKTGSPPPIFNDQVIFWHRVHPKSAVCIGGSSQQIRNTQYPQDAVFAWALVKEPSTVSMSVGSNQYWNFHADGMGPVMNMVPFPSSLGGGVTPQVSIIRNGQTIHFGNSSHAISSDCAYQNFNPVVSLVGDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE4</accession>
    <name>A0A6A7CAE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="26525at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="144" mass="15950" checksum="8DB3368E94CD6422" modified="2020-06-17" version="1">MADQAAQSTNFKEAFALFDKRGQGRVQRDSLGDLLRACGQNPTLAEIRDLEAQVGGEVDFDSFTRILNRPGGFRDPGPAEEYCRGFQVFDKDLTGFIGVGQFRYILTNLGEKMSDEEVDELLKAVDTSSGELNYVDMVKTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG2</accession>
    <name>A0A6A7CAG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidylyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_240102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAG2"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="288" mass="32615" checksum="8297EE9174AA362D" modified="2020-06-17" version="1">MSDQDENYRLLELRFKDDLQDFQSSSSTFRKLRTIDPSATNEAPETLFILDSSFNPPSVAHHTLALAAIHNCYSENFPKPARLLLLFATMNADKAPEAASFAQRLTMMNLLAEDIIKSTRGRANEYPVMPIDICVTTKPYYTEKSRAIQAEGQEWYSGAPKHIHLMGYDTLTRLFASRYYEGFHPPLSALSPYFQQNHRLQVTLRPSGQFGSVDEQRSFVERIRDGHLEPEGGKREWAKQIDLSPPSSKVGVSSTTIRRAACSGNDETVSELCTPNVAKYVLRERPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAL2</accession>
    <name>A0A6A7CAL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAL2"/>
    <dbReference type="OrthoDB" id="3644474at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025509674" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="32491" checksum="2F7655A3559C3734" modified="2020-06-17" version="1">MWLITLVPFLAKLASALPQNVADACTTVTTAVVIPTTTATYKSTPVVTVHETTPKDLGTFTHVTTISSTTTIGTVTSTSIHCTAQTQLAPRVTVYASAPTNHRRSPLELEARACTVTVTTTTHYGQTQTFVQVSGVTSTYSDYTEFTMATITQTKYNGKAYAMASAVATTDAQCGSTNSGLKPTSTVTMDARCAPSAMTSAYNGFGIDYADNVPAGGATYTATTDDASQCCQLCAESQSCAASSWDIRNHRCVLEFPVDPNKGTLNCGEGILAFYNAGPNHPMKPGTGLFVRAMCGDVEFGNTKPDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBD3</accession>
    <name>A0A6A7CBD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBD3"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:SAGA-type complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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    <dbReference type="InterPro" id="IPR017884">
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    </dbReference>
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        <property type="entry name" value="TADA2A_B-like_dom"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
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    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="50466" checksum="68CDC80FF975B125" modified="2020-06-17" version="1">MTLSKKGGGTRFVCNFCSNDISSTVRIHCANPICKDFDLCVECFSKGAEGSNHDARTHSYQVIEPHSIPIFVEDWGADEELLLVEGCEKFGLGSWADIADYVGNYRSKEEVEQHYLDTYIHSSKFPLPERSNPNDTSLSDAIPRDEFQARKKRRIEQRKTERAANASASAAVNKKPASSVPSCHEVAGYMPGRLEFENEHLNEAEEAVQHLQFTPGEGIDPSTGDFDPDTKLKLLVMNIYNDRVSLRTDRKKIILRHNLLEYRKNTAVEKARLPDQREFYAKLKPFARLMSPANFEQFTRDMMKEHDLRQAIKQLQTWRQQGITTLRAGKQYEMELANRLAQQTKKQDQAAAVKSFALPYRISPTTAYPDDDASNTTLLLPKERELCSEHGISPQAYNVVKAEIFVQSSQNDGKLSKKKFKAMVAAPKAEVIYEFACRMGWIVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBS2</accession>
    <name>A0A6A7CBS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_208460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5391043at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BNN0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="176" mass="19669" checksum="9E87CA1387358773" modified="2020-06-17" version="1">MLQRIFLSNDESSWPRCSYIERTSPLFGALWIPQRDSHRHALSPLRPTLLPQKNSARLVITQRVEVSGHVVRNTTCTAPVMIRFVTFSASNAMILPSTRELIMYLAGVHAKPPIQFNDPSLQGTVLGTLDLFYTIVPKVDCNLHDVEGFFCNQIPSIEQEGSGNLDGEALHSLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPB6</accession>
    <name>A0A6A7BPB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_223852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MU006058">
        <property type="protein sequence ID" value="KAF2857216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPB6"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="161"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="301" mass="34646" checksum="2C79A475523D4C0A" modified="2020-06-17" version="1">MTDPNTYKLNHTMVRITNPEASLKFYKFLGMSLIEKKTFPDHKFDLYFLAYDSDKSTSKGKHWTDREGILELTHNYDAEKPSNGNDDPLGYGHIGLYVDNLQAACKRLADAGYKFQKYWSDGSINVIAFVVDPDGYWVELVATKPIEETASITTTDPEEYKLYHSMIRVKDPKISLKFYEDVMGMKLVTTMELPDSGSTIYFVGYGDDGEGLVELTWVHGSEKKEGQVYHNGNTEPKGFGHLCISVDHLQKACDRFDEKKVKWQKRLTDGRMKNVAFLLDPDEYWIEVIQNERFRQPPGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPM5</accession>
    <name>A0A6A7BPM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_202462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006051">
        <property type="protein sequence ID" value="KAF2857306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPM5"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="410" mass="46486" checksum="C9BC9A7CFD31BF43" modified="2020-06-17" version="1" fragment="single">YRQQGNLTKARAMLEFALTGRERLCGENGDAATSSANELAHVFFCKGDMDKAEELYYRTLHQRIASRGSKSPRTIETMIDLATVYNRRHPELARPLYLQALRSCRETLDPKHRISLKAISSLAAHYVDGGQNDLALPLYLEAYLGYNHRLGRRHPTSLQHAHDFAVCLMNLQRTAAAEMLLVKLQEWCSAELGEADELTLAVTHSLGKNALEYADFRRAEEQFWTAWTGRKQTLGERHVLTIESLYQLVPVYDRQGKQQQALDACVHVLQARERSLVLMHPDAVEVMLNLAKRYGEQGQLIEAERLFRKAQKGCDLNKGPKHKMTINASHMHALILAILGKLGEAETLLRKCVHLFYEVYGVSHVKSVTVTFHWGLVLGKQGRFDDAIKSLHLARRDFGRTLGADHHMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQB2</accession>
    <name>A0A6A7BQB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_266821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQB2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="16204" checksum="A8A07A2B40BC04A7" modified="2020-06-17" version="1">MAQTAKGMDIRTMVDCARKTSPSLIQRMSLITAGTLVDSHASKAETSVMANSSSNRQLRMTRGETSVSCGIMACVRQSAFCKTMSGLTVRAVNTAMGRVAARSSSIKALVKQVGNEADPSSVAEVAAKILAWGRAASQTSSNSICVAGRPQYRL</sequence>
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</entry>
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    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8701" checksum="423F125A3308687E" modified="2020-06-17" version="1">MNDKLVAQGMLAFAAIRKSRNYHVYIMFRDICLATGLFNTLMLRNAIWKFHAGSPDSCCGGLEERSTKMLDVQEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BSF1_9PEZI</name>
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            <fullName evidence="11">TMEM1 family protein-like protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </evidence>
    <sequence length="1320" mass="148294" checksum="25C7A04E8D9D74F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03798">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="31"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="92"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="460" mass="52542" checksum="CFB9FA17108DBCFB" modified="2020-06-17" version="1">MLRRLLVHHQLSLSLNLMLVGTLFYVLIPSLRSWLRAFAQLSYADAVGGFSPGPRDLYLVCSFIVIFTAVRAFCLDYVLIPLAVRCYVRTRKARLRFAEQGYMMVYYLLYWSWGLHLFIQNTPPEVHDINSLLISIWTGYPRLYMSQGVKLYYLSQFAFWIQQFAVLHIESRRKDHMQMLLHHVITAALIAGSHSYRQWRAGNAILVCMDIVDFIFPLAKCLKYMELQNACDVAFGFFVLAWVSSRHIAYNAICYSVYSQVSNVVMPYGTYSTRTGAQLSTEGGHEITANLLQPFLYPESETVSFNASIRFFFLALLLALQGITIAWFIMICRVVVRVLHGKGAEEPRSDGEDEEEELEIDGKDGSVNVDKIERDEVEAAQPLDHAFGPALSRQDKRRFIEVESSSEEIVTSSSRISGTRKKPKGISSSLNLGEHKTILNRIGCLSEEQLAREREKREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSX0</accession>
    <name>A0A6A7BSX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_272682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSX0"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="379" mass="41413" checksum="76ABF26A1B80C75B" modified="2020-06-17" version="1">MRRLATRCFSTSAWKQEIRRLDELPSCVRPSFTEIPYHGLHSLKWPQPPHNILLVGKSNDQRVQGALVEFSRHIKSTYPDTNVILEPEAAQNLHAEIEFAVSAQGEGDAQYQDTVDMISTFGGDGTVLHAASLFATAPRVPPVLSFSMGTLGFLGEWSFSDYQRAFHTAYYSGIDKKSMSRVIMRDRLRVGIFGPDGKRIPHEPPFTPTGQQCNDVLALNEVLLHRGALPHMAHITILIGSPPHQQTLTTAIADGFLVSTPTGSTAYSLSSGGSIVHPLVHSLLLTPICPRSLSFRPLVLPAHTPITLRIDAENRGKEIEVSADGMRRQRGLGAGMEVRVVGENGTSGVPFVLSSNGDDYWVGGLNGLLKFNNQFGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT41</accession>
    <name>A0A6A7BT41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_272755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT41"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="477"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="580"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="701" mass="78592" checksum="8D6EFB3349F0D718" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTL5</accession>
    <name>A0A6A7BTL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </source>
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        </source>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTW1"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="68592" checksum="7DEA2E9B731607CC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTW8</accession>
    <name>A0A6A7BTW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rheb small monomeric GTPase RhbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_221907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTW8"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21059" checksum="5E0E62E29A0C69E7" modified="2020-06-17" version="1">MANPLRQRKVAVVGSRSVGKSSLTVQFVEGHFVDTYYPTIENTFAKSVDYNDEDYALEIVDTAGQDEYSMLNSKHFIGIHGYMIVYSVASQHSFDMVRILRDKILNHLGADTVPIMMVGNKSDLSEVHRQISPTKGRELAKELGCGFIEASARYNRNVTQAFRGIVAEIEHGSSRREVPNPGAEKCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH5</accession>
    <name>A0A6A7BUH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5581181at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein K11-linked ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAPC2"/>
    </dbReference>
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        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
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        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
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        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="481"/>
            <end position="757"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="873" mass="97716" checksum="8BA3A2C5E8C3A2EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUM5</accession>
    <name>A0A6A7BUM5_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_221313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5364946at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L30e-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="128"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="247" mass="26811" checksum="AC5AA73A86336827" modified="2020-06-17" version="1">MAKSEVKEKKDRKRKSTDALDEVKEKKVKKFKDIKEVDGKEAIVEKKKKKSKTAKEDEADGEEKVKKNKKAESALVTEVAEPAAKADDSDEEADGGADVDEATKEAAIKKAAVPFANPLCDDPKMQKKVFKAVKNAAKNKTLKRGVKECVKSLRKCKASTGQDVPAVVILAADISPVDVISHIPVLCEDKGVLYLYVPSRAELGAAGATKRPTSVVMVPAPKKGDEDGEFFSELQRVALKLGQHVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUQ9</accession>
    <name>A0A6A7BUQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1771-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_236906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUQ9"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
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        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="27586" checksum="D4ADDE1FC7B1CA41" modified="2020-06-17" version="1">MASLGGKAFNHGPSAQAEAEYDRLRAAARNEKGQRQHFAAQARQAYERGDGARAHQFSQQAQEHGAAADQFNRQASEFIFRENNAVGKVTPDTIDLHGQYVEEAEEILEQRIRYAQSTGQTHLHVIVGQGNHSAGHVQKIKPKVEQICAELGLQQHTEPNQGRIFIDLTGGQAGGPQPYNYDQAHQPQAQNYGQPYYQTAYPMGGQPTYDHGAAAAGYPGAQQRPHGNDYEQPSQDHSGIRICGIKICTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUW4</accession>
    <name>A0A6A7BUW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_265503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUW4"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30098" checksum="1F273A665AFDFD09" modified="2020-06-17" version="1">MTSFSNLLSTVGGQSNPAKPTSTNVSLKATNVAAGVKRRSEEKDVSPTKNVKVERSMPANRFQLSKPAAQSATAGKNAPAPAQSQAVAPASPKKGYAAVLAKAKAMQEVAASAGRIKHKPMEPHKKKERERFKEQAQKSSGAIGTKPSIGNNAKGVNKQNPVVAKEAVKRIHQPLSYKGTMRATVSSTKERAVQKAPSRRDQNEYASWSDVDSYGDEEEDENGYESESDMEGGFDDLETEEQNALRVARKEDREAQEEEERLKREKMLRKKASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV07</accession>
    <name>A0A6A7BV07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_112118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV07"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="298" mass="33179" checksum="FC84FE9834ACAF46" modified="2020-06-17" version="1">MSIDPRRRAQVAPTPPPSNESVSQTQVVSHDTTNGSKPEDDFKLRFFCASNNNRSMEAHLRLTTSPSPYPTISFGTGSLVRLPGPSISQPNVYNFNTTSYASMYDELAAKDLRLYRSNGILPMLERNRGVKWGPERWQDWRIGHPRTGKRWMDAEGVAHAPDAGQVDYSNDKGYEGTEAGVVDIVITCEERCWDAVVDDLLTRGSPLNRPVHVFNVDIKDNHEEALVGGKAILELADRLNAAAAEERAAWIRTNGVPNGFDSGHVLARSGFDERVPDILAAWQEKWPTLPALWTLAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV55</accession>
    <name>A0A6A7BV55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CheY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV55"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="267"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="48759" checksum="8EF62E7B9154C9F4" modified="2020-06-17" version="1">MRKVWVKRPGASATLVQVNDGDLVDDLREMILKKYANSLGRTVDSPDISMHISPRPAGDAARTLRLLGPDEDVCRTVDRYYPDQQRVDDALIIDVRPPDRRIVFSPRMCSVSMRPDDLAPVEPAGDYFPPMGVVPEVGGIDAQTRTLSVLNAGQATPLLSPAATRRARPPINRQHTTSPGRLMQQTTQTSRRVDSDSDAQQSDDAPAPPPLPSPPGTEAPNKSGPPTPMATTGQQTPGPRPSRRSKTQRPVPSAVSTILDVSVPPISVLLVEDNNINLRILEGLMKRLKVRWQTAVNGQLAVEKWKKGGFHLVLMDIQMPVMNGLQATKEIRRLERINGIGAFSKPQPTANGAADEQGKGGDKDILPKGDGLFKSPVTIVALTASNLQSDRHEALAAGCNDFLTKPVNFVWLERKVKEWGCMQALIDIDGWRRWKDFASKRESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVH5</accession>
    <name>A0A6A7BVH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cwf21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_300424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVH5"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15178" checksum="9127B2883EF05C53" modified="2020-06-17" version="1">MSANIGLPTPRGSGTSGYVQRNLSSLKPRDQYPTSNQSQEEVKKLEKRKPDAAILEHERLNVLEDESWDEDQIVVRCEQLRKELHGKAIQTSTKETKDLKSHQVHEIAQAKSERLRRALGISREHQQRQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVL9</accession>
    <name>A0A6A7BVL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_282667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVL9"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="213" mass="23213" checksum="21C38E553546E476" modified="2020-06-17" version="1">MPPPRLFVVRHGETEWSLSGKHTGETDVPLTAAGETRITATAAAMIGEEGKLITPSNLAQVFVSPRTRARRTLQLLNVGGNVPVQVTDAVREWTYGSYEGLTSAQIREKNPDWDIWRDGCPGGESPGQIKERLDAFIEEVREGFHRPVFEGKKEKGDVLVVAHGHILRALASRWVGQELGTTRLLLEPGGVGSLSYEHDDIKQPGLVLGGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVP2</accession>
    <name>A0A6A7BVP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVP2"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="10626" checksum="9434F8133FB58768" modified="2020-06-17" version="1">MAKYTQKELLHLRDSPLVKRPAHLPAIEQWIEYVFDDSNGTRERLRIPHSEGKSNARQPRTSGAAVAMGSFGHCNLAKARAARGGLFHAASFLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW28</accession>
    <name>A0A6A7BW28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_114072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW28"/>
    <dbReference type="OrthoDB" id="5399926at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22909" checksum="ED7CD1346B5CA0C3" modified="2020-06-17" version="1">MAERSYLRDSTGPRVIDSCVGGSNAGRRTRPSRTTTSQRHQKNERPSLELDFVNQPPEGVALGYPVGISVKVSLRLPPTFAADRRMAASTIDTSHLLAVASLVADNPRNGERVPLEANILTGQKLFDSVHRDDQQQMPALSSRVVTLGYLSFPSLLIRQSGLFRFRITLFKMQNHNNAGGTSVVAVDSEPIKVDRRCVPVQPRRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW39</accession>
    <name>A0A6A7BW39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_300352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW39"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="39049" checksum="10C7C72FC421F450" modified="2020-06-17" version="1">MGNQKNPSFLLEKPNHFTYADRPIPHLNNPEHAHSVLIKVQWTGICGSDVHYWVDGAIGDFVVKAPMVLGHESSGTIHSIGSKVTKVKPNDRVAIEPGIPCRRCARCREGRYNLCAEMQFAATPPVDGTLTRFYRVPEDFCYVLPESVSLEEGALMEPLAVGVHIVRQAAVVPGNRVVVFGCGPVGLLAMAVAKAYGATTVVAVDVNEKRVRFAEGYAATCGFVSGREDAPEELAGRIVGDAALGDGADVAIDASGAEACVQAGMHILRAGGTYIQGGMGKPNVVFPIGLLGPKEPTIKGCFRYAAGDYSTAVMLVATGRVKVKELITAKFPFEKAEEAFVETRDAKGIKILIKGPEDEFTLNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW82</accession>
    <name>A0A6A7BW82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_220098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-mannitol + NADP(+) = D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16767"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="5"/>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW82"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="265" mass="28262" checksum="BF0D83CA82AACD97" modified="2020-06-17" version="1">MIEVPKTDSLKEMLNLKGKVIIVTGASGPHGIGTSAAYGLAELGADLAITYASRPEGGQKNAEDISKKYGVKCKAYKCQVDKYESVEELVNAVTKDFGKIDAFIANAGATANSGILDGSVEDWNHVVQVDLTGTFHCAKAVGHVFKKQGYGSLVITASMSGHIANYPQEQTSYNVAKAGCIHLARSLANEWRDFARVNSVSPGYVDTGLSDFVPKATQDLWKSMIPMGRNADPKELMGAYAYLVSDASSYTTGADILVDGGYCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW97</accession>
    <name>A0A6A7BW97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_282629</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW97"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="375"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2859490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="550" mass="61172" checksum="D1284C9476D183EF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWF7</accession>
    <name>A0A6A7BWF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_219965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWF7"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="29384" checksum="A7D9413309EAFE7C" modified="2020-06-17" version="1">MPLASRRLAARLYSTTTSPLHRIQSSCRKVICIGRNYAAHISELKNPTPTQPFFFLKPPSSILLANKNDPKGSEPNRSSPKESPPSILRPKGVSLHHEIELGLVIGSPIRNLPTTIPLKETLSYVNNYVLALDMTARNVQDDAKRQGLPWSIAKGFDTFLPLAGPVDKSSLPRPEDVEIWCDVNGKQRQRGRTNLMLFGITRVLAEISSVMMLEPGDVVLTGTPEGVGEVKPGDVLECGMRDPESGEVLAEMKVGVEEREGGFVYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWH7</accession>
    <name>A0A6A7BWH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_258757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWH7"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="13387" checksum="5DBE93A104F7A43C" modified="2020-06-17" version="1">MPPPRRRKAQNDPLAILTQIALLQLGFYAAAAVLITFSALAAGWKLSPDLFLDWRSVRTDAATGWTLALCWILVAGVILGMWACRWRELQPIEFGFGRAAEVEMSLLGNTGRESGGVEREGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWL9</accession>
    <name>A0A6A7BWL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_93617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWL9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="100" mass="10763" checksum="BFA217FEB5A7D052" modified="2020-06-17" version="1">MAPAVAGGGIILVAHFAHTKLIDPQKSDGMLNRPVIIQTCPVSKWGSGKRSTHISATVHCGDTVGGGVAVAVREERGTETRQTPCFRPDMNPYLLQIRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWQ9</accession>
    <name>A0A6A7BWQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_93953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWQ9"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="21785" checksum="5A2423DFAAE0D244" modified="2020-06-17" version="1">MAPVVTLETSMGPVVLELYSNEAPRTCRNFATLARLGHYNNTIFHRVIHDFMIQGGDPTGTGQGGMSIYGDRFADEIVDSLKHTGAGVLSMANSGPNSNSSQFFITLAPTPWLDGKHTIFGRVMEGMRTVQRMGLVKTGADDRPVSEVRIMKAKVVGDIPEDKEHDPKQRQKQLKESWDVKRELKREEKVKQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR8</accession>
    <name>A0A6A7BWR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TFIID-18kDa-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_277699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWR8"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="325" mass="36885" checksum="A226787A2D2E0DFD" modified="2020-06-17" version="1">MAQQNNKAKYRTEIQQMMFVCGETGEVGAETTTMIEGLVQQQVMEMLKRASETAGLRGSRTITTEDLFFLIRHNKAKTSRLKTFLSWKDVRKTAKDSDEKGAGGGDGGGVDEFELADPTLGAGPSVGTRTSKNKKAKIRLPWDVNSFYNVQVPEREDEEDEEEEELTAATLQRLKQADERTKSMSPEEYLHFSECRQASFTFRKGKRFREWAGFGVVTDSKPSDDVIDILGFLTFEIVTLLTEKALEVKAAEDAVKRGADDESEQRKRKRRRVEPGLFDQTADTRTPVGPRHILEAFRRLQKPDLRGRYMSGVHHGSWQRPFKLI</sequence>
</entry>
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            <authorList>
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                <person name="Bloem J."/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="212" mass="22458" checksum="55989EC96B083CDE" modified="2020-06-17" version="1">MPGPEVEVHSNTKISPPKPPWPHLSDTGPSYFPFPPFPPPPPWRYTPSLPRNPSPSPPSSARTITHQKTPPHLTPKPPPSQPHLNPSLPPATQTGSGNATSAHESTDWAQPAVFSTTATASAPAHSHLHPQPQWENSGAKGARQIKPAPANSTMKGGLNTDSGGGASNRGRETIAGEVVIFPCNVNMGKVSLVMEEEEVEAKPLKVRGKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXE6_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BXI3_9PEZI</name>
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            <fullName evidence="3">Glycoside hydrolase family 23 protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="22548" checksum="036C888B9208C8D7" modified="2020-06-17" version="1">MPTAAPLPKPFSGYTVYKGDGTVAQGWPAQSSWVSSFSEAWNMNLARLKTSCASFNVPSNSPSELVALQAAILSSAASSGVDARFILAIVLQESGGCVRVPTTSYSVSNPGLMQSHEGSHSCNSGAQVTTPCPLDRLQGMITDGVQGTASSSVYSLQGGIAQAGSTDVSRFYKAARIYNSGSIPAGGDLTSTAGAATNCYSSDIANRLVGWTSEVSGCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXP2</accession>
    <name>A0A6A7BXP2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
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        <name evidence="6" type="ORF">K470DRAFT_219433</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="168"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="21645" checksum="FF58E278CDBDF794" modified="2020-06-17" version="1">MHTLATLLFLLTTHAAAANWAERHMSEEHHIDAFDAASFFIMHDFSNNNEWGRDDILKMYGLKDASTNHITKVQKESAVDRVISLYDRDRSGTISFAEYTVGAAQGIELPDFGFGSGHHGDDEYEYEIHHFEKYHNEDAREEDLTHEEDKKHFKQHDEIERQAERQSQLEKLPIIESNIPSKFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXQ5</accession>
    <name>A0A6A7BXQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_271157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="209"/>
            <end position="540"/>
        </location>
    </feature>
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    </feature>
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            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="760" mass="85536" checksum="A95F3683DD858782" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU3</accession>
    <name>A0A6A7BXU3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_217595</name>
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    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
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            <end position="22"/>
        </location>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="16724" checksum="F8899B3CAC9B9FDD" modified="2020-06-17" version="1">MRLLAFLQVILSFLLLTPTVTAVPVASEPSPHLFRRASVTDTFREWTKFLRHSRELFPGESYSNVRISLIRAMGALFTCYGDGKSYEECDEVRYHLKKARNNWRKYLNYVGNPWIPKDLEHLAFRKDAQPDVFKEDGYYPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
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    </gene>
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    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
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            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
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    </dbReference>
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            <end position="15"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">WW-domain-binding protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860127.1"/>
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    </dbReference>
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            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21475" checksum="98D75AA685253876" modified="2020-06-17" version="1">MQQPTAALPFAPLPQEQLRFTSKPRVSLSLSTPAHFPGRQQQAFNITASGGKVYLTNRRLVYLPDKPKDGFQNFAAPIMSVHDSRITSTIFGPNSWTAVVEPVAGGGIPVPPSGVVELKLTFKDGGVFDFQTELELIKERLHLAADLGPEAEFEDLPAYQEHGGPLPHMEDGARPEQMFSPPLDPPPGYEDTRMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYT1</accession>
    <name>A0A6A7BYT1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">K470DRAFT_300022</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="42133" checksum="0AEF7B9C50EEFF0C" modified="2020-06-17" version="1">MGLKVEWKLVPDDVRLEEETRPDYDPEQWYPVCVGAMLGTRYQSFVWLCRDSLYGQFENVMSELKMERELSASEKIRVKSIPGKETLSTVLNQFDIIHRDKFHRCLVFHPLGLDLITQELFYERAIVEVLRGVDAMHPAALYPDNDRLATSDSDEFAFIARKQFWNPLPRKFLKDRIMCSTSHYIFPHGIPLRFYGDLTNRRFRAPEIILGMEWDYKVGMWSMGEMVLSLFGFSPYDFRESDKEHWSDKKHLHRWNHIFGPPPKAMRLFRWNVLNTNISTGVWIATAKVWCLESKEFMGQRVKGCNKILFINMMRKIIRWLPEGRLDEAELMSDDFLSRRKCEGVEIKPIQFAGFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ69</accession>
    <name>A0A6A7BZ69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_74795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
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            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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    </feature>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="849" mass="94335" checksum="6EAD6514B51BE5F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZJ1</accession>
    <name>A0A6A7BZJ1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Piedraia</taxon>
        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="27175" checksum="AB8B82AA76BBD948" modified="2020-06-17" version="1">MADPLSPSNLLHSGLWTLAYLKDDPKILETALKANPQRVIELYEEALTAASLRCSGCSLGKAKKVHKPRHHDGSRRTRRSRSNRQPTRSDREPSHKGQATLVQATTSNANRLIGTATNQPTGMDALAALPASSSNQIINCQSKKFRALDRISRKRHADGRITREASRARVALQRCVRCNTHGHMADNCLQRQHAVPDRRLISGGASYQNTSMQNNEAMQKIQREQGGKQWQPSSLLSSAIPAFKR</sequence>
</entry>
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    </gene>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="12539" checksum="18A6F2821E245891" modified="2020-06-17" version="1" fragment="single">ERPPPSKQHVCDELDEDGKICGSRFERSEHLKRHKTKHSLQRKYPCPLEGCKGAMARGDNAGDHFKTHLKGPRKGQRNRHIKWPELHSCLLMAYDEREATKMIAKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C081</accession>
    <name>A0A6A7C081_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2860864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="66" mass="7399" checksum="AE178329239D105E" modified="2020-06-17" version="1">MLPRLREQGWPAFSVNWTGSFMTKRACSVRLGGHTTQSAPLQCELPQGSPISPILFLLYVQPIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_276659</name>
        <name evidence="6" type="ORF">K470DRAFT_276666</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAF2860777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="38"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="627"/>
            <end position="719"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="81332" checksum="7CE8154F7260364D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0N4</accession>
    <name>A0A6A7C0N4_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">Putative cytochrome c oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 480.64</strain>
        </source>
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        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
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            <dbReference type="ChEBI" id="CHEBI:13193"/>
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            <dbReference type="ChEBI" id="CHEBI:61715"/>
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        </reaction>
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    </comment>
    <comment type="cofactor">
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            <name>heme b</name>
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        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
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        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
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            <end position="160"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="437" mass="48574" checksum="ECE1BA547A47D5D9" modified="2020-06-17" version="1">MPPLLRSFHHLFQRTFARSIPKTRNNSTFFSATLPRNAPLSREASLSRWPATSSPSVGRFLVLSSASVFGIVVFGGLTRLTESGLSITEWRPVTGTLPPRGEEGWEREFELYRASPEFKILNSRMELDEFKKIYWMEWGHRLWGRVIGLMTVGGAVWFVARGRVARRDAWRLLGICAGIGVQGGIGWWMVKSGLKDPVGEQPRVSQYRLAAHLGTAFVVYLAMLGSGLRILRDGKMLKEPGRALERVGRLRDGRLRPFRGAVLALAGLVFVTAMSGALVAGLDAGLVYNDFPWMGQGLLPPRREMMDPLYAKKPDQSDLVWRNMFENPVMAQLDHRILATTTFCAVLGLWAFSKRPHLKNLLPRDVQKAVLGTVHLVTLQVCLGITTLWYLVPTPLAAAHQAGALALLTGVFVLAGRMTVPKRTVKLLEAAVKSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q6</accession>
    <name>A0A6A7C0Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="16891" checksum="75652E63A04F4A5C" modified="2020-06-17" version="1">MLSINNEADLGCCREMQNDPVASSTHANGDNAIAYPDRAKKVSENPVVNSECVNGDAHPDTSKETPDELATDANDDAVNGAAHNESTNHKTDVNVTNVHDTFDEDEEREGIKIRLDELDQRLNEDYKFYEGMARFLAEASRYLEHMSNSCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0X6</accession>
    <name>A0A6A7C0X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_276542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119428" checksum="9EDE9C2B188696F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C169</accession>
    <name>A0A6A7C169_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_276483</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="24140" checksum="C71C467BAEA60D24" modified="2020-06-17" version="1">MLPRNGVTRIGSEITAQGAPSTYRGSISNQELVGAATVATQWPGTQTALAQAQIDMFPSPSPAKGLPTYSQPLQTQASTPGPQRMSSTSMTPQPVFPSTQAVMNNLWTPWSGNRNTFVRSPYTANQSSTRSPLVQTRHSTNSPTQHQTSPSPSPQQQQQTQQPAQEPQPQQSARTTLSPAEATTIEVKDDHHNEEDDCVVCGDVVFQLEARSCLRPKRTAKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q1</accession>
    <name>A0A6A7C1Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_257008</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q1"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="109"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="40886" checksum="2A599C82EDA3B3C7" modified="2020-06-17" version="1">MDPYLSNTTTLQKYLALPQRGQVIAEYVWIDSTGSTRSKCKTLPKAPSSIKDLPHWNFDGSSTGQAMGDDSDVYLRPVAMYADPFRQGDNILVLCDTWMASDKPNAFNFRHDAAILMEKHAKHEVWFGLEQEYTLLDPSGWPYGWPKNGFPAPQGPYYCANGTGRVFGRDIVEAHYKACIYAGINISGTNAEVMPGQWEYQVGPCTGIELGDQMWMSRFLLHRVAEDFGITVTFAPKPIPGDWNGAGLHTNVSTKEMRAEGGIKAIEQAMQALSKRHAEHMRVYGEGNEARMTGRHETASYDKFSWGVANRGASVRINRAVAEEKKGYFEDRRPASNADPYQITGMIVETICGKAEGADMFGRATDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C1</accession>
    <name>A0A6A7C2C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_281652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2C1"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33495" checksum="9BC88B55FE219941" modified="2020-06-17" version="1">MPGKTAYGNFHDFCRDTGSRHSTLPVCNLFKESPVQGGRRPWYNGCSLLGVHLGGGRFLANLGSIIVAFLAVLTALFLLFRSNRKRAAVGRREMQMFLGSFMLVQICEILSVGHFPLNSSVQKAFSAIHIAAIVSTAWILMINALVGYQLLDDGTPLSIGLTFGSAAAFFIATGYIALDTGFDFTHTWNDSLTGQNRHYSLYTLYLLLPLVFLVLFFLLEAVLVLKVLGEKRPMIYLVSATLLFAIGQIFQFIASPHICRGTHGKINGSLFETLFTLAAVVMAWIFWDSITEDDWPSATGDGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C325</accession>
    <name>A0A6A7C325_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_281226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C325"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861910.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="438" mass="49215" checksum="6061EB26432D754A" modified="2020-06-17" version="1">MEFDPPVEPYSTSDKTSFAYVSARDRWPVILTGAIDDLHKAVSATEDPSRQEEGKHITKALATLKYEVQHDRRLTPLEGNGPDIEIYNHELSQRGNPKWFNVSWLYAECYLYRRLATLFSQSQRWQGYDVFSTQKTQTFHSSRSAVLELAERYVSILHTLSTQPPTLEASETLFTEILKISLWGNATDLSLLTSLSPDQLTHLQSSNHRTSSDSKILVNDSADAFVHLTSEPPGRVDIILDNAGFELFADLIFAGYLLEAGLAREVVLHPKDIPWFVSDVVPRDFAGLINALASPVWELDGKEREVLGELVGHWTKLHAEGKLVLRPNAFWTQPGSFWRMPHAERGLYGELCASGLVVFKGDLNYRKLVGDCMWEPTTGFREAIGPLKRGNVLALRTCKADVVVGLPEGKDEELRGGKKAREWAWSGEFALVQFNKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C389</accession>
    <name>A0A6A7C389_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="7791" checksum="78F12E499D4CC029" modified="2020-06-17" version="1">MSYSTSLSGLSGDWAEMCASPDWSRRQVYGHVMSRFVTTSDSWSRAVTTPDSCSRDGTPTRAAIGRMGGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3C8</accession>
    <name>A0A6A7C3C8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_269385</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
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        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="781" mass="87007" checksum="7B54B07ADB375D60" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3E2</accession>
    <name>A0A6A7C3E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_299185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
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        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
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        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="26922" checksum="7A193D560293F047" modified="2020-06-17" version="1">MAADTADTVLLPGEQVPGNELPRSKKGTVAIGPGLYNIPPTTVCATTSGVLQTDKRRGGLWLEPSRGRYQPAVGDRVIAQVQRSGGEQYSCSLTPHTPYALLDNLAFEGASKKTRPKLEVGDVVYARVSKASRYEDTEIECVQPSSGKAEGLGPLRDGMVFSISPGFARRLMMGMNEKTKGGLVVLEEVGEKMRFEVAIGRNGKVWIDGDSTKAIIAIGRLLRKCDEEGWDVETQRQMAKRELKGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3M3</accession>
    <name>A0A6A7C3M3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_26477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
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        <property type="protein sequence ID" value="KAF2861963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="288" mass="30931" checksum="B04B49755C232F86" modified="2020-06-17" version="1">MPPPERISYLGPAYSYTWEAAQCLIPDGGQTVPKPTIAQIFSSVCQGEAGLGIVPFENSSNGSVHVTLDLLRDCIQGTYDSIQVKGEVQVPVRHCLAVKKSETTTTEIKKVYTHPQAWGQCKTFLATLPQETERIDTSSTSRAAELVAASADGDSVAAICSRSAAKGYDLTISKEGIEDRPGNGTRFLVLEHSGRGSAPPAPPEDGQVKSLIAFTVREDAPGALAAALAVFHNHGLNLTSINSRPSGESNWNYCFFVECVSPNTVLDVTMRDLGTSTRECKWLGSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3R5</accession>
    <name>A0A6A7C3R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3R5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="25851" checksum="1C0D33853DAEDFFB" modified="2020-06-17" version="1">MPNPQIITQAIYPDPTMDGTIEDHIRVADPQPHKFSVPYTDGCVESVSAVRNRFMGREGSGPTESSISRSSINESNRSCSRCRSNTGSRVRDPYTKKQQRSSGTHSQYDKDSHRDGYHHDGNRVRDSYTKKQQRSSGTQSYHGKDSHRDGHHHHDKHEHHNERREHGKHHHHNKHGHHGQHHHHHKHNHYDDVQYDERGMPIQTDEERAEAGAQAAVAVINMIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3T4</accession>
    <name>A0A6A7C3T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_33788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3T4"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="414" mass="44257" checksum="0AEC86D4AC09775F" modified="2020-06-17" version="1">MAAERLSSVLTHLKPGQNPVDRITQKNPDDVVITLALRTPLCKAGKGGLKDTPLDGILFKLLQQVLQKSRLDPQLVEDICVGNVNDSKAAYYTRAAMLAAGFPNTTAGSTVNRFCSSGLKATQDIANQIEHGDIEVGLAIGAESMSSGGDRLERVFVDDIMNSGVSDAVDCLQPMGQTSENVAKDFNVTRELQDRYAAESYRRAETAQKAGWFADEIAPITVTRDGKSVTLTQDEGIRPGTTFEVLSKLRPAFPSFGDRSTGGNSSQVTDGAAAVLMMKRSKALELGQPILAKYVGTTVAGLAPRIMGIGPSIAIPKLLGKYGLDLDKDIDVVELNEAFASMAVYCRDTLKLDWQKMNPRGGAIALGHPLGCTGARQIVTGLSECRRRKAKVLLTSMCIGTGMGMAGLFVNEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3V4</accession>
    <name>A0A6A7C3V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_16248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3V4"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="152"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="287" mass="32535" checksum="7FD06139D9A2E6B8" modified="2020-06-17" version="1">MDAPGKRKRDNEHSGNQKKRTITKKQWRVLRKNEYPAKQSATIQPGDSGIWATCNKGKEGKCVTELRELFNVYAEKLYPTAATQQTSAASQELIADDEDIEQAIQREVAEIRKPSTPQLFTHVHINMPCVVFFKTIAPVDPVSLVRQICEDVLEHRELKRTHFVMRLSPMTMIRRASTEGLEKVAREVLYTHFHQGPASPKKFAIRPTIRNHDTLTREEVIKQVASIVGPNHSVDLKYYDLLIIVEIYKNVCGMAVVDGSFERLKRYNVSELLGPTPKDAIGQMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3V6</accession>
    <name>A0A6A7C3V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_256135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="27544" checksum="B1728F4AF6390930" modified="2020-06-17" version="1">MSKAPPTLINLPPPPNEMQTPVDAPGTPNSTTTSMSELSMVAIKDGHRGHLPHHYQPLSSARNNQLDAERADRISRLAGMERVSTTRSMTPSSLTPGAVAPPQPAQSYFDSSGNPAIIRERSTVGSASATGSVGGRTTWAGSEVGDADKMSESQDMELDGSSVGGMSEDQGSLVGFGEGARTPARQPVVKATTPTARDVKHDTHMIDANDYTARKRDISSRGGAEQAERIVNEHMDTSGDERMRGGNAQQADLGKFGFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Q7</accession>
    <name>A0A6A7C4Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_213418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Q7"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="485" mass="53431" checksum="9903895C1DF738BE" modified="2020-06-17" version="1">MTVETETVASVPQSGLAERAASGRNDVSTLRLKPSSETIRPRKDRRKPGAKARSINQGTASTKADLFEARVASAVDEANTSDSDETFVYESNPEPRRSRHHSRTPSVASLHSIVDTQRAMLRTAGEMDTPRVTGKRSFKFSNPPFSDVDSADNGGGTVRAYQPRYIGGKYGRGVSHASTVEDSPFTQATKSRSTHTLRPSRPPSPRSPSGQQRVSLFSRKDNLFDFDPEACDDERTPLVGSIRSPRGLGRTHRTHYERHPRSRFRRFGGCLLGACVLMAVVLSTVAFLALSNRPLSDVRVQRIDNVLASEDELMLDLVVSAVNPNVLGIAVGSMDINVFAKSPHVAAMTGGVDDGTDPPGEDLGRDAHTMLLGRIFDFDQALSFGGSPLKHHAHSSRGELRLAHPGNVTKAGEQNRWERTIQHPFELIIRGVLQYQLPISNHMQRVSVGASVMVHPEDGIDETGRMRVKPLRPREREGMRLDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C550</accession>
    <name>A0A6A7C550_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_255792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C550"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="499" mass="55297" checksum="E7D3E8CBC4D9DE51" modified="2020-06-17" version="1">MRRRTLQIALPLRRHVTTTSSPLNIAVIGSGPAGYYTTHRLLQRLPTTNFQITLLERLPCPYGLVRYGVAPDHEEVKTSGETLTSLAREHNGRKFHFIGNVSIGDSATQLPLRYVQQNFNVIILAYGASEDRKLNIPGESLRGVHSARDFVGWYNGHPDFADAAPNLDCERAVVLGQGNVALDVARILTTDPTTLRKTDIPSHALKTLSESKIREVQVIGRRGPLQAPFAIAELRELLTLPGLGYKPPPEPWEELVPYPEKELPRQLRRIVQLLKKHGDSPAPCTGAKWWQLGFLRSPVEFLSTDSTNLSAIGFDKQSLNHTALTGDPEKDLYDLRSIRVVPTGEKTLVHSPLAFRSIGYRSTPLSGLEELGVEFDEIRGIVPNDPWGRVMGKEGRPVKGLYCAGWVKRGPTGVIARTMEDAFATADSVVKDYKLGVLGEESKGGFDGLSKVLKERNLRPVSWDDWLAIDKVERQRGGEKGKEREKLTSVWDMVGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C612</accession>
    <name>A0A6A7C612_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C612"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="59" mass="7054" checksum="A62D9CEF60EF027C" modified="2020-06-17" version="1">MPLSMNETMTHLRENFLYRGKNPEKFRLLSMVLVMCCKTSLLRHNLAQHRLQRTRGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C630</accession>
    <name>A0A6A7C630_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_213091</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C630"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="22">
        <location>
            <begin position="330"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="20">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2862435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="642" mass="71480" checksum="912E7BEE9D57ADB2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6A6</accession>
    <name>A0A6A7C6A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_291421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6A6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17196" checksum="E2E8F8960BCC6440" modified="2020-06-17" version="1" fragment="single">PTSSFCYSSSSLSLSTAPHVHLQSNTAISYHSFAVWAMRTYPDIMNSTMTSISAILGSSHFSVEIMGRNAAYGSVSRRRTERHHATLCGGFAIFDSNFNVRNTSVTSSWAGGCRMNTYYDSYVRLKDEGALDVREWQFGWSELSSRYGKVERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C769</accession>
    <name>A0A6A7C769_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="235"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="310" mass="33049" checksum="210BF10ECA39DA0A" modified="2020-06-17" version="1">MWSTWDVLQNLNSSDRVINYLHDLRYRQTKHPAQELDEAFGPVGEHGAAIPPPTSRDPSVANSPKSTKASSVAGSPISARAPNVAQSPKFAEATSVADQPVAADSHDTTDNQSVGDDKGVVNDAIDNDNVAEHHSPRHANARSVSATPQHDPLAELEAIPENEPEAMLEDEPEDEPEAMVEDGPAAELDAIVKAEPEGEPEGEQRLCICEGAVQSDNLLACDNEACPIERFHFECVGLEKKPSKNRKWYCSQCKPTVASKGKAKAKTKATTKGVGKGKDKPKPVKAAGKENVKDGGKGKGKGRGKGNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7L8</accession>
    <name>A0A6A7C7L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_211715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_1"/>
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        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHIT_BIND_I_2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
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        </location>
    </feature>
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            <end position="286"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="593" mass="67024" checksum="DE3631740E2D4790" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7V7</accession>
    <name>A0A6A7C7V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_280143</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7V7"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025367248" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="21">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="22">
        <location>
            <begin position="327"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2863493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="468" mass="50232" checksum="D372899443BAFC25" modified="2020-06-17" version="1">MARLRSLAAVTAAVRLVQAVNTGFNYGAIMSDGSAKSQAEFEAEFNRAKSLQGTDGIFTSARIYTTIQAGTPNTPISAIPAAIKTKTSLLLGLWASAGPEVYANELIALKAAISQYGSAFTDLVVGISVGSEDLYRISPTGIENHSGVGIGPDVLVKYIQQLRSTVKGTALAKAPVGHVDTWTAWINGTNSAVVDALDWVGMDTYPYFQTTMENSIETANHTFFAAYDVTIHSAKGKPVWVTETGWPVSGPKENLAEASAKNAEKYWYDVACTIVGNVNTWWYTLRDAEPTTPNPSFGIVPSDLNAGPLYNLSCHHSSTSATHSHPTEPNRVCGKSYNVTINSHRNTLLNFDIPASYEGKTCSLVMLLPEHSQLQTSAYTFNNKGGITVNYLTHAVTEKVTYNSMPKDSHNGVGKVESVRAGGKWVLTSSPCKAGTTQCFELVGTGGLELEFFQDYNPSPIGVFVTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C812</accession>
    <name>A0A6A7C812_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_210396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1664" mass="184526" checksum="3B99DF626C51472B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C867</accession>
    <name>A0A6A7C867_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_274261</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
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        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="450"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2863766.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="482" mass="55360" checksum="104001C05B1BF947" modified="2020-06-17" version="1">MSVRQAYEYQQGSAERQMNDDSDVEEEALANDYREQVGYQDGEDYDLDRSASLGGAQDLQAQLQAAATPLEYQASTEMKMQSYDSYCNLFHFILNSEGPVDIELPSTYWAWDVIDEFIYQFNSFCAHRQRVAFQQTSGQANDEEIALLRDNPNAWGCYSVLNVLYSLIQRSNIIEQLEARKRGQDPAQFAGEYGSKNLYHMLGYFSIIGLLRVHCLLGDFSLALKTLDHIELNKKAMFARVTAANVDTYYYVGFSYMMMQRYADALRMFNHILVFVSRTKNFQKGAQYDNIHKRVDQMYALVAICVALSPTRLDDTIHTALREKYGEQLTRMQRGGPESLPIFEELFQTACPKFIAPTPPDFDNPASNIDPLEHQLAIFMDDVKNNMHCPLVRSYLKLYTTMDLKKLAGFLDVDAETLRSWLLINKQRSRQIRHSEGGLLEGDVVNSSDLDYTMQGDLIHVSEAKVGRRLIDWYIRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8N2</accession>
    <name>A0A6A7C8N2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_209948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MU005959">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025706228" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="558" mass="60780" checksum="40F2F090B51F2242" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8W4</accession>
    <name>A0A6A7C8W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_125602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8W4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025495184" evidence="1">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="369" mass="39854" checksum="D1D68D5AC042E19E" modified="2020-06-17" version="1">MKLQHIGSTFLIALLASFTAAATIPSLIKTGRRKVRDSPRESVLQLSRGEQAALPYPPDMLPGGRDMNTPYGSVRVYEWGPVTGHKVLFVHGISTPCPVFTKVAQSLAEKGCRVMLFDLFGRGYSDAPDPSAYPQDIQLFTSQILLVLSSSELSWKNFTLIGYSLGGGIAASFTSYFPNMVENLVLIAPAGLLRPHRISLTSRIVHNPLFPGVVTKAIVRRRLLASQAEEEIDPGHPALSSDSLALYGDKPNMSPAKAVAWQVESHPGFLSSFTSSIQNAPVTGENARWHLFGQRLSAQRAEGKLVNKVLVLLGRDDDIIIADEIEEDAIAAFGAENVSILRLDGGHDVPIVSASGCVEAIVQLWGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Z7</accession>
    <name>A0A6A7C8Z7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_279825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Z7"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="507" mass="54994" checksum="523BC954A3DA702E" modified="2020-06-17" version="1">MPPKKGLSLYAHLIGDQNNTISSAPVKYDVTKTEEKKKDASLQFQPIRRPQVQSKSAKPKVPQPPNANLNSASPAAGSAGAPPPAEGQNQIEDWLGDDDEPVQYEKPKYVRGGRKKKKKAQQERVEEDWDDIYDPSRPTVFATYKGSEEQFREIQDWKARLYHHQSVVKAKEKAATSREYIDNDCGIVADMVSDVQVPPGMSFAPPNFDDPPMQQAVDDADDDLPPPPTHKPVETVSRPPIAFAPAETVTQTPKSASLRGNGESVDMATKKADALAKVAAFKAKMAAQSAAAPAPAQPSATVSRAPVCYDVAQPETNVEPTQSNRPGQKGFAERLLKKYGWEKGQGLGAQGEGITTAIVAKAEKRKKLAGSEGGGYAAPKNMGRLVGGKRRKVEGAQEDSGPGTLSEVVKLQGMCHDMDLDHEIQDKDLFGEIGQEMESSYGKVERVFIWRREQGGNDDVFVKFTSPLSALRCVTDATGAAGGMTFAGNEVSATFFDAEKFEKAEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C901</accession>
    <name>A0A6A7C901_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_267760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C901"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32245" checksum="5A8CCF3BE2E59D7A" modified="2020-06-17" version="1">MTFADAYGSYYWQDCGSMGSCLARRSDEIYPSSVGGNTFLACIFLACLIAQLVFLVGFRGRRIFCAFMCLGLHMECVGYGGRIGIHYSWTEATPWIYLSTLLIAPSFFLLAIYMITKDLIIYYGSETSRFTRKPNRLPLSLAITTCLIILLFIIGLATHGYGPGLVVSIAMIFQAFSILVAIGFAVHVYRKGEKRKNSLRHTSPPLPKYRYFALACAGAMVAILVRSMFRFAWMLYYDHSEPLDLFFDGAMTALAAILLTVVHPNVFFQDVSLLRSSRLKNGEEEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C902</accession>
    <name>A0A6A7C902_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_268260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C902"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="90196" checksum="D9B42FE01DAC9505" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Q8</accession>
    <name>A0A6A7C9Q8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_267719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="18407" checksum="A25818D695A8081D" modified="2020-06-17" version="1">MQGQTGRRPPWDEESAKILKHQYLAKQLSIEYDKNPEDVTIEMHLKANWPLVIRLAASRWTAAQLWSASYLQKALTGHKVPVLPTVNGNADPRFTATNGERLCVPLIETVVEPFNNFIDKLLDPRGHPPKESYCRFNLHDGTQTAYPCPIFWTELPQTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAD0</accession>
    <name>A0A6A7CAD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_239632</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="13791" checksum="882A41A8FF146BB1" modified="2020-06-17" version="1">MLGLRAIQRTALPIGSRHYTRVADNAFTRERAAVKAHAAATSDVWRKLSIYVVIPSLMIAGVNAWRLWLEHWEHKAHDVPLEEKTEYPYQNIRSKNFFWGDGDKTLFWNPKVNYHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAQ2</accession>
    <name>A0A6A7CAQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254415</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="217"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        </source>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864155.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </subcellularLocation>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBB7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="44242" checksum="556DAD25E5D8DC2F" modified="2020-06-17" version="1">MEPSIAYIAGTAVVWLSLLFAIPALRDGFRAVQRPMGLIHQDYRAGIQWTTYEPPKLVFANNTFYANFPNKETISEPVLPPTGPTGVHVYSPAVTTYTSYDTTQSNWFIENFPWHILILTGVAASIILLWLIWKYINNTKALEVSLGDYQKLEAENKALRVENQKLQENVEWLEERIRQLDKEIEHIKKEAKDKLRTVREDLDVKLPEAVEMIDVLIKFLTHYLEPDSEPENSDGDNGDDHHGWGGDHGHSGGHDEGDDGEPDPEPEPELGPKPGPEPEPTLPVQPPPRTTETEAEPIVESDSSESDAPLPRDIEDIETEETKALLPPAHFEGTMTNWRHQWDGTAERLRQEVQKRAEVEQRSAARGDAGTNATRKQRVTQLRLDRFRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBL6</accession>
    <name>A0A6A7CBL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_292022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBL6"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025710702" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="50939" checksum="91411EAD28B094D2" modified="2020-06-17" version="1">MFLSKVLALVAAIPLAFSLPTIEVKGSKLFLSTGQQFFVKGVAYQLTPDDPLVNTEQCKLDATLMKELGVNAIRVYHVDPEARHDGCMQAFSDAGIYVWIDLDTFATYLNPTKPEWNRTLYNAYSRVMDVFHRFDNVAGFFVGNEVMNNGANSIVAPFVKAAARDMKTYRNYKGYRNIPIGYSASDITVLRPNLQNYFACGKDPMDRMEFFSLNAYEWCGASSFQTSGYSNLDQLASNYTIPIWFSETGCNAVRPRTFSDQAAILGPDMNDKWSGAMIYEWIEEANDYGLISYKASDNNKVVDGFARGGTPIPVSPDFENLKSQWATLTPTGVMKDAYTPSNSPPICPPYTTGAWEVSGDVVLPTIGVGRQAVPMMVTADVVTESVSVSKPVFTPDLSSHSYRISTPTLFETTERTRTGTATTSTTATARVTATATASAAQAIGFQTVAAAAMGSVAAIAVVFVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBR1</accession>
    <name>A0A6A7CBR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 299 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_208266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBR1"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24954" checksum="79EA102DABF920C0" modified="2020-06-17" version="1">MRPAARLLATLRTSSGRAASAAHYLEAGAPTGLTGIYTHPAPRSALLYVYNQTLQKLSKLPESSVYRQATEALTRERLRAVESKRPEGLREWQERVKSSVELNPETFSKVYISSNPKGEDYNIVWDLRDEEPAMDEKLSEEEAAHVKELTTVQIEPEPALTAEQISELEKEIGGGLIEEVILAAKAECDLVDTMAEERVWEDLVEKPVEGQWTYFERGRHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBT5</accession>
    <name>A0A6A7CBT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
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        <location>
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            <end position="107"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="17897" checksum="C65985C6A7EADD43" modified="2020-06-17" version="1">MPYHNVHEVTSAFPEEDHVVIDASWGSHWRWDLEDDARRIDLELPSNANCVSVSPNGPYAAWGLVTGEIYIWDADKDAGQMVEGHSSSVECMAFSSDSETLVSGSTDIWEWSPQAAPEKLCQVGTIIIKCIAISPNGKFVVFRSDTLLVFHCTTHEVEQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNY8</accession>
    <name>A0A6A7BNY8_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Cwf21-domain-containing protein</fullName>
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    </gene>
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            <taxon>Piedraia</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="146" mass="16757" checksum="68E186492E78D615" modified="2020-06-17" version="1">MSANVGLPTPRGSGTSGYVQRNLSSLKPRDQHPSSNQSQEEVMKLEQRKPDAAILEHERLRAIEVKVFELRDRLEDEGLDEDQIEVKCEQLRKELHGKASKTFTKGTKDLRSHQVHEIAQAKSDESERLRRALGIPREHQQRQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ92</accession>
    <name>A0A6A7BQ92_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="18095" checksum="F3640436B186D380" modified="2020-06-17" version="1">MQPLTTLTSLLALTTLSQAYFVVSPITARLQNFMYTVEFTVANPVGGIDGPDPMPTYCKLQWPTFLPAPNCYTACPGNAGYFARITSDSSISTADFSLDIAQEFSNLVTIVHQNATVKVSTRNRVAGYKCQGDVCATAPGSQGFKVEGKGGTGELENEILCVPRPDPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQP1</accession>
    <name>A0A6A7BQP1_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BQR2_9PEZI</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006057">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="13150" checksum="934E43D1935E6030" modified="2020-06-17" version="1">MPSNRLTYRRRQPYNTKSNKVRTIRTPGGELRYLHIKKRGTSPKCGDCGMKLAGIPALRPREYATISRPKKTVQRAYGGSRCANCVKDRITRAFLIEEQKIVKKVMKEAEKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQX9</accession>
    <name>A0A6A7BQX9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_223220</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006039">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
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    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025489326" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="28549" checksum="45165D2271EE9525" modified="2020-06-17" version="1" fragment="single">MFSTVNTLTLVSGLLSSAGPALGHSWIDEFQVIGPNGSYTGDRGFARGYVARTDPSFNGFSVNYQVPSDESGRIRINSSDLLCHPSQRASNYTNPSYPMLQVQPGSHVAMKYLENGHVTLPWNQLGKPKAGGTVFVYGTTQPSESEKMVDVLRWTKDGKGGNGRGFLMAAQAYDDGRCHQLNCGNVSLARQVLYPNHVPGQPTSSLEQWCESNVHIPASQPEGRLTVYWVWQWPTEPNADCTYPGGKDEYYTTCADFNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRM3</accession>
    <name>A0A6A7BRM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_160225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRM3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14775" checksum="326F21F05E07E30A" modified="2020-06-17" version="1">MLNSLFSVFGVCIPTVRGSAQRDVVFGQRTTGASRSRSLRLQLVQCTRLIGASRRRSWLEIPTYRNVQSDETAVRGDMHQRACVLFETHFARSLPSPVGWPLVFRARGQYEAVWCAVNKFSVAQCMAFTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY8</accession>
    <name>A0A6A7BRY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006026">
        <property type="protein sequence ID" value="KAF2857832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY8"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="22376" checksum="F091486642CFB1CB" modified="2020-06-17" version="1">MPTAPQIYHLTTAAWLTLQSLPTLITPRLITTLLALEPRRSTDLEVYLSRSLGLTLAALAGMSIIVSGILTDQGDQPPVRTSQSVAATDVGTPPRTTGGNGISYPTALLTTAYFFSSTFYLYMQFVARMNFGFTMGLVLNACCFAFGVWILLFGWDKGHVSKRTGMDKRVGKFPFGEKKEKERDKDKEEGGRRRRKGLPKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSE9</accession>
    <name>A0A6A7BSE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1297" mass="145461" checksum="7FC288B700BACB52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSF9</accession>
    <name>A0A6A7BSF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2108at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
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    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="78"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="52759" checksum="8C9F70159F5DB6B3" modified="2020-06-17" version="1">MASQPTNSNPKPRDRRFSTAKEPSTNELKSGMHRQFRNAHEGHMAHAGLNPSRASTGVVWTTERAAEHGFLDDPSSWANLGQGAPEVDDEIEGCFERPKQVEISMTGREYGPTAGIKPLRKAVADLYNAHHRQGKKSQYTWENVCIVPGGRAGLIRIAAVLGSAYLGFFIPDYTAYNEMMSLFRNFVSIPIPLSKVDGYHIHPDKIEEEIKRGTSVILTSNPRNPTGKMVTPQELAEIQDLCRDRATLIMDEFYSGYNYTNNCDGTVISAADNIEDVNEDDVLIIDGLTKRFRLPGWRVAWILGPKEFIEAIGSCGSYLDGGTNVPFQEAAVSMVEPTRVRHEMKALQRHFCEKRDYIIGRLQKMGFNLHYVPDSTFYLWLNLEQLPEEINDGLNFFQACLEEKVIVVPGIFFDLNPSKRRDLFDSPCHHFVRVSYGPRMVHLKAGMDGIERVLKKHNAFPNKQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSR2</accession>
    <name>A0A6A7BSR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_297007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006037">
        <property type="protein sequence ID" value="KAF2857558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="338"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1245"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1329"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1604"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1638" mass="183264" checksum="9283B1B9CB461EED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSR5</accession>
    <name>A0A6A7BSR5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_237738</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BSU7_9PEZI</name>
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            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        </lineage>
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="232" mass="27044" checksum="06674D1798E62E06" modified="2020-06-17" version="1" fragment="single">WPSPLPGNEAPTPYQIFAMGRNEHYTKTRFLQLAKIYHPDISHHSGLSRQVRLERYRLVVAAHHILSDPVKRSTYDRLGAGWERAIEVSERRSKRQDPIWQNATWEDWERFYQNCNDECTKKKCTAPVYMPNSHFAVLVICLAILGSTANSWRAQESGSRIVEKRDNVHDQAARELRRLRHQASGLSDRDERIQWFLRSREAASGKLPPTEVDAWRDESIKRLLPLNDTCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSW8</accession>
    <name>A0A6A7BSW8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="22777" checksum="D1221219A4594A70" modified="2020-06-17" version="1">MSNRLDPTTRWKEHTNIRSFRHLSQKYAIPLVEAKAGIDRVIMSIPQRSSYKSQLSSSTGNILPSAHPSPLPTKTHDERRQTFPILGRADVTLNEAAAISSINKFINAMTRPHNSHRVACAVSSMMQAICDTLCPGSQRSQPASSNLRGIIAQSPRRIRLAEYVSHRSTPTNRELCSFEAWIAIPWTARDGKDSTVSPASDESNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSY7</accession>
    <name>A0A6A7BSY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259921</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSY7"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF2">
        <property type="entry name" value="C4-DICARBOXYLATE TRANSPORTER_MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47078" checksum="FD7DF0B59BC95630" modified="2020-06-17" version="1">MLAQSEISSKTEEEQPKSSKPSINEEPVAHTRPQVSIDNRNERGWRRIVRNFSPSWFTVNMGTGIVSIIFYMIPWKAKWITVFSIMFFGLNIVLFTLALVISILRYTIWPEIWSVMIADPNNSLFLGTAPMGFATIAEMWILLCSPAWGNWAVKFGWALWMIDSIVAVIVTLVLGILLMSASHERGLHNFTAAQILPIAATTVAAGVGSEVAWTLPNAQYALGTLVVSFTMWSMAMPMIFCVLMTYFHRLAMHRMPPRETVASVFLPVGPLAFGGFGALQMGKLAMKLFPKTKTLDPMTGQIFYSLGFLTAFVLWGWGLVWFIYGLASIYISWPIPFNMGWWGFTFPIGLYAITTILIGEELPSLFFRVAGTIIGASVLLLWMVIAAGTIKGIWTGKLFHSPYLANLQTKREYTTSEKSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE8</accession>
    <name>A0A6A7BTE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzoquinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_221553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE8"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="21966" checksum="24F88A6DC1ECB4B8" modified="2020-06-17" version="1">MAPKIAIVFYSMYGHIKTLAEAESQGIKEAGGSCDIYQLPETLSSEILTKMHAPPKDQSITILEDPATLEKYDGILFGIPTRYGNFPAQWKTFWDRTGSQWQTGAFWGKYAGMFVSTGTMGGGQETTCISAMSTLVHHGFIYVPLGYKTTFPQMADLSEARGGSAWGAGTFAGADGSRQPSQKELQIATAQGKAFYEAVAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTI2</accession>
    <name>A0A6A7BTI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF/SAR superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_259809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTI2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="183" mass="20532" checksum="E229C07DC8AEF35A" modified="2020-06-17" version="1">MGGSVSKVMAKLFGSKEMRLLMLGLDAAGKTTILYKLKLDSDVTTIPTVGFNVETVTYKNTKFNVWDVGGQDKIRPLWRHYFSGTQGLIFVVDSNDRKRIQEAREELRRIIQDREMKDALLLVFANKQDINGAMSPQEVSRQLGLDEIASDHIWKVEPSCATTGEGIFEGLAWLSTNVKLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTI9</accession>
    <name>A0A6A7BTI9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_272237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="200" mass="22892" checksum="D96880D9C71B886C" modified="2020-06-17" version="1">MGSSRHRIETDVMKMLMSDYEVELVNDNMYIPPRPLEYLADKFRQEFHVKFPGPPDTPFSGGRWKIHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMYNMMNIFDSFLPHLLRYPNASDPLNGEAAALMLRDSAAYETKVKEYVARYASKDPVDDTVETRDEDTLSSVGSLGEEEEEEDEVEGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTL4</accession>
    <name>A0A6A7BTL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_135969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTL4"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="53242" checksum="D4FCC073204DBA56" modified="2020-06-17" version="1">MASSSCRRRRRRRSGRSASTKCTSSFAPTVMFDCTAGPRALPRTVVWRPCRRPTARAAARPRGRMALKRHSRPLQAPRRQLRCQSRPHRRPPPLPPTTPTTPITPTPPPLLTPTLPLTRPPSRRRLRPHRLSRRRGTAPPPHPVSTTTSSSSSRATTDSDSSTVDLSTAHPPSTTTSSTSEETRTSDSSVNVIPLISATLSDGSVTVITRSSVPFTTTLPDGQTSTIEAVSSSLTTLGNGATSVVYMTDAPPAAGAPSTLTSTTVVGAPASATSTSSSSTHSASNGGGSNTNTPPAGTIAGGVVGGAAGLAVILVFVMLFLRWYRRKAIHHHALPPNSGASVDDQTTHTLRGPGMAERAGLAPVIPSLFRHSDRSRETISGQGSERGFTRVSGRKLPSNFSPGMSRDGALSIPERNLSSASFYRDSTGFYGGDGSLSPITPTMDGSIVGASEGIALSPGPQRRPTVHAGGPYTTMNVASPQSSHFERSETPVSLEPNRGSRFTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTS6</accession>
    <name>A0A6A7BTS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_145014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTS6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="124" mass="13435" checksum="4790C1D3D6273FA4" modified="2020-06-17" version="1">MSCHLQWSFLHVASTSSPSSLTSSNASPTPTMPGSSLKRDEESFPTIIPFRNVWAVTDLGASGAHSAGGYSREEVWLQRGSEIAVPDESCKIPTFGARCSRTNTRFRQECEATEGYENAMPSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU2</accession>
    <name>A0A6A7BTU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_259472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTU2"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="78" mass="8946" checksum="CE931A6AC162D84C" modified="2020-06-17" version="1">MPQAQPELKRYLDKRVEVQLNGSRKVMGTLRGYDVFFNLVLDEATESKGDEKVRIGMCVVRGNSVVMMEALDRIDDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTY2</accession>
    <name>A0A6A7BTY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTY2"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="915"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="460"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
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        </source>
    </evidence>
    <sequence length="160" mass="18380" checksum="FB0F7FB885645F5A" modified="2020-06-17" version="1">MLRWYRTALTTHPLLTQSLTTSLLFATGDTLSQHLVERRETHFYPRTLRMAAYGGFIFGPAATKWFGFLQRKIVIPDRPNLEIAAKVATDQCVFASTNLFVFLSTMAVLEGKDPMERVREKYTEVLKKNWMVWPLVQAVNFKFVPLDQRVLLVNVVSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK1</accession>
    <name>A0A6A7BUK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_282971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUK1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="527" mass="59852" checksum="51D62E9CC84F4AD2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUM8</accession>
    <name>A0A6A7BUM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">High osmolarity signaling protein SHO1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_282948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUM8"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="33057" checksum="1CF07206BFDDD94F" modified="2020-06-17" version="1">MDYNGYGRAPAAKKFRVGNIFGDPFSLATVGIAICGWLIAFVSSIIAQISQRNQYPNYSWWALAYMFCVIIGVATAIGMNAVYTYHVAIVGFLAAGLVFTTSSVNSLIYWAQGAKEAAAAGFILLSMVSIVWMFYYGSQPTAAHRQTLDSFALHKDHAPTSRNSRHMTQAYGRPETTHSAGPPQMYNSSQLAGFETSSPVTGYAGGPAGAPARENGPNFPQPATSQSNLAPHSGPGTGTVTPAGAPSTEYPYRAKAIYSYEANPDDANEISFSKHEILDVSDVSGRWWQAKKENGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUT9</accession>
    <name>A0A6A7BUT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_296371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5371646at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33067" checksum="7C82CD204969DC6D" modified="2020-06-17" version="1">MGDPSPWTNHEKNELLAEIIKVSEPHPTKLFDFIVYHQIQPRWPDTPLPRGRTLYQCQTIYDEFVRRFPGTAPSHVHAAPYQGWVPSNPYKFPGHADPSLSGGREIRPKPLPPQHTPPLASEPLNKRKRGRPTKLEAQAKASVAEAAAAAAAAAAAQEQSLTTLHSQPRSGYMASQSSSLYAPSAAVAGGPAVRSPSASKMPISAVLTPQPSDLSVDHGSPSGKRRRTRFSRSSPEGSLRSHRPGGSSTYQSPYVDEEAEVVVKPASALGIIQSDRGASQKKPETQSTEPHEPEPPPDPLTQHSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVD4</accession>
    <name>A0A6A7BVD4_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_259087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="498204at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="38407" checksum="D7A17FB4E56B4993" modified="2020-06-17" version="1">MSESKKIVIVGGGIIGCTTAYYLTRHPSYDPAKYKITLLEASDIAGGASGKAGGLLAKWAYPASLAQLSFDLHAELANQHDGASKWGYRRLNCGDFSCAPSSTKKSHPAKNIPSDITTWISSPITSYEPIGTTNDTAQVLPYEFTTTLASLASTSGVEILTNSRATQIIPSERKVIYTSSSSEEEVTLSATEIILTTGPWTTALLPTAPISALRAHSIVIRPSGEASPHAVFTSIKDSPTSPEIYPRPSGEVYACGEGDTTVSLPPTTREVEIDFTRCAKIESAVGEISEIMGKGEVVKRQACYLPVGGPLIGRTKRRVILAAGHTCWGINNSTGTGRVVSELVFDGKIKSLPGWEDKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVI2</accession>
    <name>A0A6A7BVI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_101062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVI2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="155" mass="17241" checksum="C0AF4A604173B3F1" modified="2020-06-17" version="1">MSVTALTHGRATVYHVDGCHFGYHVSLATVCFVITTSSNCWVTVSLPSRLTRCTKPCQDSRLDNDWRETISYHCLWNTFRIQCTSNLNWRAVGFQSAAKSSVLNAPVSYLPNLFLTTNKSTSPACAYMPRETGTNDCLRTTKLSESLALCLVQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW10</accession>
    <name>A0A6A7BW10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_121249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW10"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="238" mass="26984" checksum="E9CD5BA691F99AD4" modified="2020-06-17" version="1">MIWRGHRRQARPRTAFFLCPTKPVGFSFFKTLLAPATAQFFYIATMIVYKDLITGAELISDSYDLKEIDGIAYEVDCRMINVGGEKFDTGANASAEEAEEGVDDNVQRVNDVIHSFNLEELQGAFPKPVDYGTYLKKYIKTIKAKMVENGSSEEEAAEFEKNANKFTRDVILGTKTIPSDDPAKKPKVKHENFENWEFLGGEGWSGENPGMVMLKNYREDGITPYIVFWKHGLKEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW11</accession>
    <name>A0A6A7BW11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_219571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="120" mass="13070" checksum="453CE6B5B26597E9" modified="2020-06-17" version="1" fragment="single">MRGKFVAHRLRAILSGQLPLSAKESSRLLDALTGSFRQHLDEVYPPAAADKPTVRSSAALADKHIASILTSLLLSQNPAQPSAQPTASRTDPVKFLRDRVKDGTATVEIAQLCFDNYRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW72</accession>
    <name>A0A6A7BW72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_259254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2858965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="167"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="646" mass="73137" checksum="21CCF2282F0F42A3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWB9</accession>
    <name>A0A6A7BWB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWB9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="88" mass="9566" checksum="17D1B79F46B21ED5" modified="2020-06-17" version="1" fragment="single">VSVRAKFSTSVEESTTSQCSFDLQTTGAPFSIMRDPAVDLDVDGLPAKSASEYATTFVPSCCFRQNMPLIRRAATTWSENGLAKNRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWN6</accession>
    <name>A0A6A7BWN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEC14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_220231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="334" mass="37467" checksum="E7A9A1DB3A086219" modified="2020-06-17" version="1">MAELDPKYDRYDYPTISATTQPGHPGHTTNEQDAAVHQLRSMLEQEGYKQRLDTLTLLRFLRARKFDVQATKKMFTECEKWRSEFGGGVDQLVKTFDYKEKPQMFQYYPQYYHKTDKDGRPVYIEQYGNLDLNAMRKISTDERMLQNLVVEYEKVADPRLPACSRKAGSLLETCCTIMDLKGVGITKAGQVKQYVQKASAISQNYYPERLGKLYIINAPWGFASFFSMIKGFLDPVTVAKIHVLGSNYQTELLAQVPKENLPKAFGGSCECPNGCAHSDAGPCMYYHKAEWLKPQGNTINNTAGEIVQGQPDAKAGAGTTTLEQPVGQTAPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX30</accession>
    <name>A0A6A7BX30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_300385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX30"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="27703" checksum="D11A625B53D60EF9" modified="2020-06-17" version="1">MATTQENTTKRKRFLPLENNPDVMTKLLHTLGLDSDLEFHDVFSIDDPDLLAFVPRPAHALLLVFPVSKTYQAHRQEEDQDRADYNGSGADEPVIWYPQTISNACGLMGLLHGVSNGEARNHIWPGSNLDKLIKEAIPLQPKERAALIENSEALESAHNAAAVTGDTAAPDLNEEVDLHYVCFVKSAKDGHLWELDGSRKGPLDRGPLKVDEDVLSEAALDKGARAFMKREQQTEGGELRFSLIVLGPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXF4</accession>
    <name>A0A6A7BXF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_218084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXF4"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="383" mass="44164" checksum="6CBA89E318F39C86" modified="2020-06-17" version="1">MSTSNDQLNPTIENPPRPKPTRPKRPNYNQVHSKPLPVEVFPLPDFYPSQPLSILKLCYTWISHFISPPPQPPPHCIGYFSPETRSVHVTEPNQVRKLWEMGFFGKGSLSRSEPSWLDREKARLKAQRDGTRTAEEVTEARRQERRKFKLERARLERLKIEAQRAVERGEKFESDILTKEGEEPTESKSEQTVAAPAPEQPTNNSPNTPGSPDPEIVNHEHLTLTLEEAFFLSYALGALTIKVANLAHPTPWDLLTIFTTNSTFPPSPSPTFQPDAPFLLNYVTYHHFRSLGWVVRPGVKFAVDYLLYNRGPVFSHAEFACIIIPSYTHPYWKSEQGQKERSVGKNKDWWWLHAVNRGRVGGLLRGYRVREFVVRRWVLNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXI0</accession>
    <name>A0A6A7BXI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Abscisic acid G-protein coupled receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_258446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="318" mass="34306" checksum="9C31A89E89488213" modified="2020-06-17" version="1">MSAIVEEGHESAPETVKVLVAAFDGMDMLDATGPMEVFSNALHDKNNPDSKAFNITICGPSGKVTTSQGIGIAANTSYDDATKRLGDFDLLVIPGGGTDAIIKSKGQPLPIIKAFAELQKRNPSRERTLMSVCTGSLFLAETGILSGLTATTHPDFMARLEIICSNVAQRDMSDRTDVMDARYVVNNLRFDLGNEEEKNPYIMTKKEYQAHQRRKSATSLSSPIEEGTNGATGTRRQSNARKGSMSFKISNMRRESVLKRAELRLGGLRVLTSSGVTSGVDGALYLVGALVSDDAAEETARKICHEWKKGVVVDGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXZ9</accession>
    <name>A0A6A7BXZ9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_218978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 480.64</strain>
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        </subcellularLocation>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Smc hinge domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="765"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859565.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1446" mass="161093" checksum="832FA4DE0FD67EB6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYR9</accession>
    <name>A0A6A7BYR9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="232" mass="26131" checksum="F943CCB0A5EE7F6A" modified="2020-06-17" version="1">MFDERVTYGIEEECEEILPLEVMKNIVEMVKLPTTGETTIDIGDDFSDSNLDNEEEVPPNSNNNHETRSVARRVEELFRIEFFACVGISSGHTEGQALQRSVTVSTPHRRPYFVKPLPPLPVAQPAARPRHSPPPSSSLLTPPPKRVEPMAENLQGDHQRKGRITLALAELDDEQEPAINSDTLDCALDDLVDSTLLPVCAFCFFSQVQKDKPRRRCAKKHKYGRDLVIWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="547" mass="61936" checksum="60CA9031E98D23E9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ63</accession>
    <name>A0A6A7BZ63_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_277436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="21709" checksum="3BFAC0F58AE264F4" modified="2020-06-17" version="1">MFKKDPTPGPKTKLKSSAQRSLRARLAETYPLLEPHLDDLLPKRSQVDVVKIPAERVTVYTLDGEGLFYSYAEPGTKTELLLPHLKTVHKFPWAFQKVRIDRGAIRFVLSGATLMVPGLTSPGGRLPNSNQNDDVYGNDGKDLDAGQIVVVDAEGKENACLVGVLRMGTSEMKEKKKGVAIDNGHYLGDGLWKMDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZA7</accession>
    <name>A0A6A7BZA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial 2-oxoglutarate/malate carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257774</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZA7"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="151"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="249"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="343" mass="36984" checksum="82E5883402D81F45" modified="2020-06-17" version="1">MTPSSEAAKRTTRSGMTTAKELAADTPEALEHVVDEPAQATASFLRTPVMQAALPFINGGTAGMVATTVIQPIDMVKVRLQLAGEGIKSGPKPTAFSVAKDIVASGKTRDFYTGLSAGLLRQAIYTTARLGFFDTFLKGLISRAEKRSSKVGFGERATASIAAGGLAAMVGNPADLALIRMQSDGLKPPSERANYRNVLDALVRVSRNEGVYRLWAGATPTVVRAMALNFGQLAFFSEAKSRLQSTSLNPQTQTLTASAIAGFFASFFSLPFDFVKTRLQKQAKSTSGTMHYSGMLNCFAKVMREEGPLRFYRGFPTYYFRIAPHAMVTLIVADYLGFITKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZD0</accession>
    <name>A0A6A7BZD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZD0"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="251" mass="28431" checksum="A9E31B2DBC86C94B" modified="2020-06-17" version="1">MSGQADREPVFPTRQSLGAMKSKLKGAQTGHDLLKRKSEALTKRFREITRRIDDAKRKMGRVMQIAAFSLAEVTYAVGNSQIGFQIAESARQAKLRVKTKQENVSGVFLPQFESFQKEGVGNEFGMTGLGRGGHQVQRCRETYTRAVETLVELASLQTAFVILDEVIKVVNRRVNAIEYVIIPRTENTIKYINSELDELDREEFFRLKKVKGVKERARAAEEAESKENKENKENAETTNVLGDQDEEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZD2</accession>
    <name>A0A6A7BZD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_270544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZD2"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="26284" checksum="557A36BFF8E70E65" modified="2020-06-17" version="1">MDKDTMTFQSLISDLNTLLGPSNGIDKVSISSLKSLMRSYNSQRSEWTPYAFADYSRAYTRNLVSHGNGAANILVLVWSPGRQSYIHDHANSHCVMKVLHGRLTETVYSWPCERGEQNSPIQASPIQASPIDTCETEHKCSSSETEHKCSSSETGTLRVKRAKTYGEDEVTYMSDRLGLHRIRNEDPDDVAVSLHVYTPPNAARHGCHIFDEETGRKSHVLQCSFYSELGVKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZF2</accession>
    <name>A0A6A7BZF2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_217840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZF2"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="25263" checksum="3446A8338B87BF12" modified="2020-06-17" version="1" fragment="single">MDPTDAQNAAALERFIRSPVTPEMITHLARHASRVIRCDGQAPVEAPLTPPHTPPSSQSSLPPLPEFITNLVRQSRVRVSTLMTTLVYLARLRQRLPPNAKGIRCTAHRIFLAALILAAKYLNDCSPKNVYWAMYTNVPGYPDFGFSNGEVNTMEVQLMGLLDFNLRISEHDLYWHLDPFLLPIREKEARKAEQERLCMQLAKMEQQQYSAVIERQQSAQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZJ3</accession>
    <name>A0A6A7BZJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_257693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZJ3"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="538" mass="57409" checksum="1F1FB9AEE8B6D926" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZK4</accession>
    <name>A0A6A7BZK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_276781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZK4"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C079"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="667"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="263"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="545"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2860910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="720" mass="81052" checksum="1EF2E4401A8962B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C087</accession>
    <name>A0A6A7C087_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_276737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="F-box-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="680"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="796"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="878"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="918"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113042" checksum="0627CFEE35F7C6BA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0D9</accession>
    <name>A0A6A7C0D9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_264528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C118</accession>
    <name>A0A6A7C118_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_216659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C118"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="238"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="448"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
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            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113974" checksum="63C02FCAF5BE988E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C156</accession>
    <name>A0A6A7C156_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C1F6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="377" mass="41937" checksum="63CAA4F6273B2DFA" modified="2020-06-17" version="1">MAPKTTALILAHFHPRVGYKLTFSRSDPTLSLSLAEIEYKLFPSGLHAVPSDVIYFSHADQIGVAVFQQRKSGASQRGAEFSSLGVLIPRTAGGDLWKYIPKLRELVDGEEEELEGFWGTCTLKDSLEDPTPEAENPRKRFGALVRLLGERVFMLLRFVMQGKRVLILDGPPVKRGGEVCFLLGSLAGTGRCLFSVGVRDIPLLEGEGGYVATTTDGILAEKRGLFDYLVEVIGENRVRVKGRDGREVKVGKRDWEKWSMLKGEGGILGESSDKIEGHFRDLRETFLRKLERMVEDRYSDEDTPRVVVIGADQIRALGLDPSAEMDREFVVDMVRIHLGKNGVVQSGRRRSRKVRVCGVVLGISLSVIAILIYVNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L2</accession>
    <name>A0A6A7C1L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_257091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L2"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="232" mass="26052" checksum="96DD542B48A23249" modified="2020-06-17" version="1">MDIPLLITSPNSRTERRITPSWTLTHLKSRLEPITGIPRSSQKLILQTSPPIPLVSPTEDTTPLSIFPLTPGLELQVQDIRPPGLRPNYTDVSAVEKYSMPPAEYESRSDTVLAWKKKNKLGRFDENAQHDAEEVRRRHDAAAERVKVGRRCRLRPETDQRRGEVAFVGDIGELGGGAWVGVRLDEPSGKNDGTVEGKRYFHARAKCGVFVRPERVEVGDFGVEDVDEDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q8</accession>
    <name>A0A6A7C1Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein L43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_281640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q8"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="92" mass="10216" checksum="B089780D712A40C7" modified="2020-06-17" version="1">MTKRTKKVGITGKYGTRYGASLRKQVKKIEISQHAKYTCTFCGKTTVKRHSVGIWNCKSCKKTMAGGAYSLSTPAAATARSTIRRLRETKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1V8</accession>
    <name>A0A6A7C1V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_216139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1V8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="179" mass="20050" checksum="093FF3A73B33C590" modified="2020-06-17" version="1">MSSTTYPSPLQPPRSPKRGGPQIAHSGLATVDKIWLHILPLRSSSEHTTRAPTGPIPIRMPVHQKPATRHRYSQGHALQANRPPDKRAIFLQSCVSLHRRGEGTIQAYCIILRLDCLATASGAPRQSMPCFGLSQTTWTRTMDDVDRMDYWNNDICLMTHCPVTPAVLSYNSGHRRWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5425161at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="9085" checksum="E9043878D98A091E" modified="2020-06-17" version="1" fragment="single">ATHHLQPLNFGLFSPLGNYYSQGLNSFTNMSLRQTTMTKSFFGISWPAFEKALTKENVLSAWRKTWIFPFDPEVVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2V0</accession>
    <name>A0A6A7C2V0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256941</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
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    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0140662">
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    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chap_CCT_epsi"/>
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        <property type="entry name" value="Chaperone_TCP-1"/>
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    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
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    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
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    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
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    <dbReference type="NCBIfam" id="TIGR02343">
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    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
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    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="552" mass="59284" checksum="CB529D961ABE1E76" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C328</accession>
    <name>A0A6A7C328_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025415507" evidence="2">
        <location>
            <begin position="21"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C3D6_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17271" checksum="A99FB5D508BF8F35" modified="2020-06-17" version="1">MAAPSVLLSDVLGTERATTIFAGFTRDVDSVSQRLDSKRENSTVLAPSNSALHDLPHKPWEDPAEYSQMGAEAYQGQAGEDRAARNLRRFTEAHIVPVSPWIEGEKVKTLGGKELWWESNQEDKTIIQPVNLEVEKIISRVANGEVWMVNGVLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A5</accession>
    <name>A0A6A7C4A5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A5"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2861879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="15388" checksum="AF58AC32A1BA5D1A" modified="2020-06-17" version="1">MAPTATKQRRSTGGKSAPSSSKPNIFGKSLLKPEKKKMRYKPGTVALREIRRYQKSTDLLMAKLPFARLVREICMNMVVSAEVKRWQSQAIQALQEATEAFMVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4C4</accession>
    <name>A0A6A7C4C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_213628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4C4"/>
    <dbReference type="OrthoDB" id="3642993at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025436282" evidence="1">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="17495" checksum="BFC0227A7C02BD83" modified="2020-06-17" version="1">MHYSLILISLAAATQGLYFHVSPLTITDKGKDGGCVDFTVNNPDAVYEQGGHDSATCSLPCSGSPPSCWSHCDSGHGSSAYYARVTPGSYQSASKYSIDIWQPYVYELANHNNGTVEISTDNANAHYECAPQGQYTTCETKDGGAFDTAVHPYYGGSTPADPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C588</accession>
    <name>A0A6A7C588_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_212454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C588"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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    </gene>
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        </lineage>
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    <reference evidence="10" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="507" mass="55394" checksum="DBFFFFE486435D13" modified="2020-06-17" version="1">MSNDVEKNIFLSAPEVDGVGAVRGEAFNHGTGIWARCMRVAGKFGVEQRGIERVPEDERPDRGTKALLNVFTMWFSANLVIPSFALGLLAKSIFKLGVVDAMLTVLFFNLIGTIPVCTFSTFGPAFGLRQMVLSRFYFGWWGVRLVAFFNVIACIGWSAVNSIIAAQLLHAVDNRIPGWVGIVIGAVCTLIITLFGYEVVHIYQFWSWAPALFIFIVILGVFAHTGDFQNLPMGTGEAEVGSVLSYGSVIFGFAIGWSSFAADYTVYQPATQSKKKVYFWTWLGVVPAMCFTQMLGIAVMSATAANGGDNRYQKGYDASGSGGIIDAIIVYHLGGFGKFCLVILALTVIATNCPNIYSVSLTVQVLTRRAQRVPRFLWTFVATICYVAIGIPAYLRFESVLHNFMIFIGYWLAIYGTIVLTDHVVFKRGVKGYRPEMYDTPKALPSGIAAVTAFCVGIVGMVAGISGTWWTGWIARAAGGDIGWETAAGFALVTYLIARPLELKWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T4</accession>
    <name>A0A6A7C5T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_154182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5T4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="204" mass="23780" checksum="10D47A1E20CA7DE5" modified="2020-06-17" version="1">MTLSCRLSTSLIARRFLSFEVLHLNPTVLHPRDMTPGINYSPLVMLSHIKGRQCIFKRSTARLIQMRSSGHASSWLLFHNPPHKRTHTIALVKLTRHPFARTAVRREHCPYRCRIHRNHNARLRLIRCLPVAAPWMSRLSLDWSHPARAPVPAVPLSSSSSLQLRRRRLGQAGPLVYWLQALQHQHRCRRTSHRLRSLRPPWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5V0</accession>
    <name>A0A6A7C5V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_255409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5V0"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="477" mass="53048" checksum="0F25406E18E97334" modified="2020-06-17" version="1">MTSLRPRDPYNPTELAELYPNQLQLQQVQVLLRHGERTPVSARFQAAGLPSDWPCCEAAKRMRSTVLSTDKSWDTLHWGRQIETFGPGDKPVACKGPSGETESICLPGELTDLGRATTLALGQRIRHLYVDQLGFLPDSLDSASAIRLRATPIQRALESVQQAFIGLYPPAKRLPGVDPPTVVTRTHPQETLFPNEANCKRFGQLAAGYAERAATIWNDSPELAYVNKRIGKWMPKESPVAKVDSHPRLSGIMDSINASRAHGAPTLLPREFYDDQLLANVDKICVDEWFAGYAESTEYRKLGIGSMVGDLAQRMVERALDQPSFKMSLAGCHDTTLAATLASLGGFDPKRDSWPKFTSSIAFELFRHQDARPRPKSWFSVFSSELDTRRPVSDMSAAERQRLDGHYVRLRYNDRPVILPHCARPENHFANDPAICTLTAFKQIVDSFTPADWSAECRSSLGQPTLKGEVEHPLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C659</accession>
    <name>A0A6A7C659_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase iota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_212420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C659"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="63874" checksum="2502A82C27923B67" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6N1</accession>
    <name>A0A6A7C6N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_153198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863192.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="355" mass="39947" checksum="861C2E4A5343840B" modified="2020-06-17" version="1">MSVRSNTASASGRHHARTPTFPLYHSTRKKPRRWPLVLRVIKGAIHMDVAIPVCAHGAFAALICYLDHNTSGHLGIPSSVLPSLSIVVGLMLVFRNQTSYDRFWQGNQHLTNVASCVRNLTRAFLACSHDIGKTLPTEVQTADTERTVRILVAMVYAAKHHLRAEWGATELSFLVSSRNVERRRQESESLAKPEYYDLLPTGTRSYEGHGLGLLLQLSVHVETYIKRCVDRGWFHPPQASQMSVQLNQLVASYGNLETIHLTPLPVAYLIHMRQVLAIFGAVLPFALVEDMGWWSVLLTAFITFTLYGIEAIGAQLEDPFGYDRNDIKVDAIVEDLRVETFVLLDEWRRGSNIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M0</accession>
    <name>A0A6A7C7M0_9PEZI</name>
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    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="18084" checksum="7F56B61D7CEBC86B" modified="2020-06-17" version="1">MKVRFPQDSCFRPANDLLTIYIQVWEVVPQNRSVMQTHTQWEKPKARFRPVKPSRIRYPSRSSTYCDFPTPYGYSKTPPTYGQGAAYVHRTKTFTHSASCRTKMRLEFPEEGGKEDNEGDHISELGRAGQDVLPDSVLAVSQTAIWNICKLLWTDQGA</sequence>
</entry>
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    <name>A0A6A7C7X7_9PEZI</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="35"/>
            <end position="107"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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            <end position="178"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="20127" checksum="422DC3B5D0060ACD" modified="2020-06-17" version="1">MEPQRSAFTTPHGTKRARPSPSSSSWCSSSSEQKIPRPRNAFIIFRQAHSQQVMRQLRDTNGQASTGQVSAVIGKLWRDASAETRKEFFDRANEEKRVHAIMYSGYKYQPKRKEVGKGRNASQGGGSKKRVTRASKRLGVEKEGAEEKVEETETEESEIGENQDRFSDSNCDDPTWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C874</accession>
    <name>A0A6A7C874_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254606</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9J4"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="236" mass="26376" checksum="E85A34894C749A8C" modified="2020-06-17" version="1">MAQEKFYKLSAVDSLLYPEEDTHHSPHDGPPHDGPPHHGPPHHGPPHHCPGHHGTSNLTVYQLIDKSKYTTKLAKLINEHDDIVEMLNSTKAKYTVFAPTDQALKHIPCDGDHEPSKEQLKDLLLYHALDGLYTAKRIFFTHTAPILLQSTRLSSKKEPQRVSFQLTLRGLSVNFKTRITHPNIMAVNGVIHAIDRPLMLPLEKASLLSLLPSRFSTRELALHKTGLIETLTSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9J5</accession>
    <name>A0A6A7C9J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_287161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9J5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="216" mass="23598" checksum="0725F5BBE0C17F1F" modified="2020-06-17" version="1">MSVFKTHMQHHRVLYAGLGLGLLVSVAARSLASTTVTFWGNRKRDDKKSSEEGSNVLKGDGSDTYFSALVVLALNPDKEVSEAAIEAILKEYCHHGLHSADFDAENSGDIDEEAGRRLRTILPFLRRYGITRDPVQEEQNEVNTEGAQQNGSTVEGAQQTGLTQLNSQPTSGIPEGAITALRRRRNASSAYDFEQEAARVTIEQGSGRASYTNVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9L6</accession>
    <name>A0A6A7C9L6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase-like protein sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_297576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9L6"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="254" mass="26810" checksum="B14BD055F21C80A0" modified="2020-06-17" version="1">MPYTLTNRTLLITGGSRGLGAELSRAFASAGCNLAINYASSTGPAESLLAELQSSHPDQKFTLLRGDCSSTSACAELVHSTLRELGALDGIIANAGYTKFAPFGDLNALEEGDWDACFAVNVKAPLELAKQARHHFEGLEEGGFVLVTSSVAGVSLSGSCMAYSVTKAAQVHLVKCLALAMGPKVRVNAICPGLLLTEWGLRYGDKVEELKGQAVLKKETDVKECADAYLMLARNTAMTGQAVVVDAGLQIQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Q4</accession>
    <name>A0A6A7C9Q4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_279952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Q4"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="127"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="517" mass="57063" checksum="DE66EB4063BD1F6C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9V4</accession>
    <name>A0A6A7C9V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_297714</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C19 family. UBP8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9V4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="151"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2864173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="490" mass="54511" checksum="B8F0A75FB13C8EC4" modified="2020-06-17" version="1">MAITMAASDRPLKKGSGCYHVQRLMEAAHQDAVEGYTKIVKALKAGPGIATQTYRVPQTQEVRISIQPSYICLQCGHVSKNRERHIKQHPFAIESTEGLVYCYDCHDFVYHREFEEIRTGGRVKSARVNAEEEQMISSHTSKLPCSAVGLRGLYNMGQTCFMSVILQALLHNPLIRAYYLAEGHKSSECERETCTACALDDMFTQFYGDEKHEGYGAVNMLQASWKGDGGLAGYSQQDAHEYLGFILNSLHGALTEGDEENTSNRDCHCAIHQTFGGLLRSTVTCADCGAVNSTVDPFMDLSLDLKLAPLNFKKKKLPATQQTVKEILPLDLADCLGRFTGAETLGRESEYKCRSCASASGAKKHLEIERVPLVLPIHLKRFSHSRSLKESKKIDSKVRFPLNLDIAPYVVGGTLDSFSAADQGLQYTLSSVIVHKGKMDSGHYISYARQGPHEWFRFDDSMVVEVDEREVLGAEAYMLFYVNVAPPIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAH1</accession>
    <name>A0A6A7CAH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAH1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23377" checksum="490AF45763C16CD8" modified="2020-06-17" version="1">MFTPEERRLRNRNAQAKLRSDRKKKAETLEKYVRILRWGLKECLEQRKQGGNCQGPGLGEVPKGPDPESTYVPEAVHGLENFGPIFLPLTPAKLEEILQRTADMDPSPIESLEPETPSIWTETPLSTGPSLEPIPCPTVGFGDEIFPGFDPSVFPSYGAESCPPWLPEWMVGPLYTDDGEEWAERDTANNALFPEYNGWMHSCNGTGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAZ0</accession>
    <name>A0A6A7CAZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_274263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAZ0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="271" mass="29551" checksum="15A11362B2247EB7" modified="2020-06-17" version="1">MAVMRVMKVMVLTVERAELVDSLDNPANLAEEVAIPAGRATAGMSTAAILPTTAVEGTTRGGGAAGQSHRSVQSKTALGGASASHRPSQNRGLQCGNPSHIGPSNVDGGSASYRTSQIRTLQGGDPSHVSPSASTRLHQPSASEEFSYPFPLRYKAVALYNEKHPNSQATVPSYEVMASKFWSVSLPEGLLKAHSSIFDNFDIARDPNVTVEKWFRERYICTFVLLHALRRRMERQYDLSPPSDEELVEMDNWVAGHAQHLHMLLEDVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDE9</accession>
    <name>A0A6A7CDE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_208950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CDE9"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="438" mass="49714" checksum="809A8B1B77C352C2" modified="2020-06-17" version="1">MRDVQSNIDGLWILNLSMQFRDRSQREKFFVTYADPSSKWYRVTVSVDYGNIPKSSELGGLDCLISQEEKACKIYEALRESLHKIPFYNTVTNLRVEYDEGERMCIHVEEDANEIVEYPTLSLFMHIQTLHYRENELQFDSHLSGYVYKVKVDGLALIKKEIPGPYALDEFMYEVNALNNLQGCPSVVQLQGLVVDDPPGEEENQDQGPLVKGLLVSYASKGTLGLILERATGLDELSWDRRVKWAQQIVQALSSIHEAGYVQGDFTLSNIVIDENDDALIIDINRRGCPIGWEPPELKPLIKSGQRIGMCISTKTDLYQLGMVLWAIAKICSEPEREDDLTPLSTTDAPEFYCDIVDTCLRNRPQERATASTLLQSFQHNAKSTSESRQDDAAVDVADDEIRKSRRRMDSGLGDIDIDEDNFSVTCDDDRFRPGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPN7</accession>
    <name>A0A6A7BPN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_12776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006062">
        <property type="protein sequence ID" value="KAF2857152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPN7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="224" mass="25763" checksum="CF260A69074779C2" modified="2020-06-17" version="1">MAPHPRMKRREINEGRPFYQLDTAGFLRMEARIPGLQVAQHPEVLKPSDSEIVSTAKPAELSGTWQEAQWKRDPRLQRPVGIVLVMGERKHVELGDVLKFFLRLDMRYAFFYGREVHRSRGKMAGVKRDIIMRPIEECDTPSLIIEAKNGRPNITDDTVLFLEETDILEAYPALEFGIALYGVHSTVRLRRFSHTPIPTAVLRPTRDWRYCTSLSTSGMMGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPU2</accession>
    <name>A0A6A7BPU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006052">
        <property type="protein sequence ID" value="KAF2857294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPU2"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="8128" checksum="36CFA6BDB07E46E7" modified="2020-06-17" version="1">MDAALGELYALIENGIKPNSAATAKKHLVDRTTLYKWFQGLTVGRDTALEARRNLSQEQEEELVSNYLVGYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ03</accession>
    <name>A0A6A7BQ03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_273341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ03"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14622" checksum="8E5721725DD136C8" modified="2020-06-17" version="1">MSVLVAPFDPSYLRIGDDDSLTPVDIMPLIELPPDVLFRIIDELADTEDVAYFRAPPHWRGKSLRRKSNDLIACRLVCKAGTTVALSVLWCNAPLYALVNIPNTSHRQEYASRIQELVLSDVERSVLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRK4</accession>
    <name>A0A6A7BRK4_9PEZI</name>
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            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_223459</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="298" mass="33676" checksum="04AF02782B5AF94E" modified="2020-06-17" version="1" fragment="single">MVSKEQRAWVEEQLKALEKAQAEINQGVKGVRKFLDLSALQCAEKAAYDSRDYSGDNLDGDFQLCLEGTRVDIIETIRNWATTDNEQRVFWLSGKAGTGKSTIARTVAHKLAEQGYLVGSFFFKRGVGDNLSNAPYLFPTLAHHMADLIPSIGDRIADVSSRANSKALKEQFEMLIEGPLSGYNTGSATDVRAIVIDALDECDAREGVGQAMKFWPLLSAHTSMNLRVFVTSRSDNAIWRKLGQLDPKYFQYRKLENWQSSTIKDDLRRYCEIELEKIREERKNNMIPDKLGNEWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRL0</accession>
    <name>A0A6A7BRL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquinone biosynthesis hydrox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRL0"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="35096" checksum="346C4C714E84D4BA" modified="2020-06-17" version="1">MCENNNLTSALLELVAGSRIQVWDKTKVESIKLGESHEGLDLSQWPLVQLSHGSPVATRLLVGADGGNSPVRQFVNIPSPGRDYGQHGVVATLTLDQYLSPGATRKAYQRFLPTGPVALLPLPCNAASLVWSTSPEHAAALKNMAPEVFVAMINAAFRLRWDDLEYMLSHAVTVDEIEWRQSATASTGPAVPSVTAVEPQTRASFPLRIRHADTYVSPRVALVGDAAHTVHPLAGQGLNLGLADADCLARRIAEATAQGMDIGSTWCLDEYTRKRWPANHAMLGAVDKLQILFRLGGPVPWGRGVGMDLLQNLGPVKKAIMKFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRP8</accession>
    <name>A0A6A7BRP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRP8"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025661855" evidence="2">
        <location>
            <begin position="20"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="651" mass="70206" checksum="F58D9E802632E3A4" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRQ5</accession>
    <name>A0A6A7BRQ5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_223488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1517790at2759"/>
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    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31003" checksum="5357CE186ED3DFE7" modified="2020-06-17" version="1" fragment="single">LAGNYLKRLPSELFSLSNITVLSVRNNSLELLPAVINQLSRIQSLNIAGNKLKHLPWELLEIMCHRGHHCKVIIRPNPLVQPWELGEWIASADPKMISGKDNYSGRLTRDDLDLRLKSVIRSLDLDHHISDGNCLIYLASSTIKYFTIDGSRVSAAHVTKAVHCSVPSLFELKLRTLQALDCTRSVLTSLEPYISPAMMSILDRTISFPAEFCSVCGHPFIVARAKGMEYWFRGQHGQVGQQELRPDAVLPFLCKACSWACAQPRKLGRVCLSQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRS3</accession>
    <name>A0A6A7BRS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_266408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRS3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="315" mass="33906" checksum="6D9823AE251E0A67" modified="2020-06-17" version="1">MHHKTWASKDDDDAAKTSTARKVSTGRISIGGVAEEKGSENKDTCASILVDNESSDVSNNDGVKTGAATAPKVKEETQRPNNPPKPRRSRSVGSTPAKESKKSTVTTTSAGKQNKVVKSSARSSQSSKPTPKKNAPPPAPARPAAASPTPPPPSDEKVTWGYVRAHPNEVFHFARGGILARGPPPPDSAINVTIGPTPQDGSGQYARRQARIHAEKNPTYEEDDFPAVKSLVMKKMGPDRFPKVTWYYRGAGYWSRSNGDGHEDEEMAESHGEGEEQDKDEEMTDADADSEEHEPGEDDQESDGSSEDSMQVIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS18</accession>
    <name>A0A6A7BS18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
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        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS18"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="414" mass="45822" checksum="8FB3F6E6B5BC35DD" modified="2020-06-17" version="1">MRRLAGDQAALRSKELPPYYLFAPDSEDNDDLAQLDILLAGPSHTPFAAGVWNLHLSIPSSYPQQPPEAYFRTPIFHPNVDPRNGAVCVETLKRDWDASLTLRDILVVISCLLIQPNPDSALNAEAGALIRDSYDSFARRAKMMTSFQARVPDAIKDAVIEAQNRGQERPAPPRNRTARQRGTAASSRHAGDQSPSVPTRQFVVPQSADDVFDAPLPRVPRADENDESLSSPKPRSLPGRLPTIRRPNGAPVPLGELVIEPAPFSSDEEESDSSRVDGDDHDTDDDDGMEYPPSPTKSPSPRKRVVALRDGVRRNHKAAAMDITPPGNYPNPLAFASPFTAPRSTGLKERDASPSPMKGLLFPKKVTRQVERDREETEAVKMNRTLWEKCGHDVHRWNNGDFDGGAIQMRLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS42</accession>
    <name>A0A6A7BS42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_260938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS42"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="38833" checksum="B670E445AA30641D" modified="2020-06-17" version="1" fragment="single">MAKQQESNKKRQRNVEEGKLVIDISLPEPPSKKAKRLEKKKKSKTTTNKPPNPPKQESIHTKETKETPPKKNPSPSIHSIWIANLPFSTTKSTLRTFFASAGITAESITRIHLPTPSKPSNAKNKGFAYVDFTSPAEVEIALSLSETLLSGRKVLVKRASDFTGRPDEGNNKGGDEKRRDAPTSRRLFVGNLGFETTLEDLREYFGTEDCHMATFLDSGKCKGFAWVRVPSVEVAKGFVGGDGGDLLHGRKLRCEYAEDGAVRYVRRFGGGKGGDTKGERKQEGKDEWIEEVDGSKKADEMKKGKGVLNAEQKRAERRKRHDLKVAQKEVQAPSVKRTGAIVQGSGTKIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSE5</accession>
    <name>A0A6A7BSE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_237110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSE5"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025708390" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="310"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="51215" checksum="0A86F8CA493457D4" modified="2020-06-17" version="1">MRLPVLGLLLSLLSFAASLSATGSNVLVVIEEEADKNKYRQFWTDLEQRGFNLDYKSPKESSLSLFAHGEPAYSHLLLMAKSKGLGPALTPNLLVDFINRGSNIMLTLSGDAQVPSAIGNLLAELDISISPDRNSVVIDHFNYDVKSAGAKHDVLLLPSPNFKHDKNFFAVDNLVAMPRVVGQALGNASPLLASVLHADSTAYPSNSNEELEEMFAVGSQLSLVTAFQARNSARVTVLGSAEALEDKWFSASVQLPGGKAATRTSNQEFIKKLSQWAFKETGVLKAGPVRHMLNEPVKAGERDTAAIGHAYSDIYRIKNDVTYSIELSEWTGDKWTPFVPPFNDSVQLEVSMLSPFHRLNLKQSSQTENSTIFITSFRLPDQHGIFNFYVEYRRPFYTNVEEKRTVTVRHFAHDEWPRSFAISGAYPWISGIWVTIFGWLAFVNLWLFSKPAALQGKQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSJ1</accession>
    <name>A0A6A7BSJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSJ1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025637167" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21755" checksum="599E58169D300B10" modified="2020-06-17" version="1">MHSLQTLFLLATAASAVPLWFSEQSSCDISSASMPSGAILPPPSGTLYHVALGVGSQNYTCSSIGSEPTSVGAVATLYNVSCMAGNEPSILSSLPSLAVSLSGSSLSTLALMGAEQKSGSHYFLDKTTPYFNLDSAGHQYGEAAMHKAASADAPDNTYSVPWLQLQGSEQFKEVYRVNTKGGMPEQYCAEVGNVEVPYSAEYWIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT26</accession>
    <name>A0A6A7BT26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_278985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT26"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27107" checksum="1F38654362D3A268" modified="2020-06-17" version="1">MASRFAKTALGATRVRPTALPLRSFAPTTFATTAAPKAETPKAPQVPQKDPKSTAESFLDALPGNSRSSKAAILSAGTGLSAVAISNELFVVNEEAIVMVSLLTIYWALYNYLGPMYRSWADGMADKYKNILNAAREHHTNAVKARIGTVKDLSGVIDITKDLFAVSKETAQLEAQAYEMEQKTALVSEAKNVLDSWVRYEAQVKQKQQAELAQTVIARVEKELKDPKVLEQILKQSVADVERIVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT83</accession>
    <name>A0A6A7BT83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_221214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT83"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="309" mass="34806" checksum="8EAB806B3BE40EE7" modified="2020-06-17" version="1">MTPEEKITNFVFKSLHNVTQNGLSIILLGTINSEPALVIIKHLPFPLSPTQLTSLTKTFTSPSLIGQNDIYTWLTAVHLGPVKLDIIHPATAKHISKYASQQYRSVLETPSIYTTHTLPRITRLRSNGSVTWVHNILSGAAEQDSILFRNEDFILAPDLHFDGRSREGFHLLAIATREDIASLRDLKVGNLEYLKNLERDIRTAARDLAREKYGWRDVEDEDLLVYVHYFPTYFHFHVHVTFVGGEVGAAQAVGKAWDLRSVVVLLEGRKEAGGRGLEEVELRVTVGVESEFWKEVFGPLREGREPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTA0</accession>
    <name>A0A6A7BTA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTA0"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28850" checksum="353599EC322E82F0" modified="2020-06-17" version="1">MSDDSDRPNWQKPQDEQSRDEAPAEKYSAPNASEFLRTHQPQQPQQPQAPIITYPEFLVEAHQPAPLITASRVVNTIYAASGVVALAYGVSKFLIQPMVDTLSKSRQEFALHTISHIEELNDRLEKLVSTSPSFLSDSSSTVSDDPAELYHRDVGTQTSPQSSRSPSISGEFHNTLSAQVNVLSNLKKKLAEANDSNNPNEAPLREIDELKEYLGTVIYSPPIFGTNQGQRKDYEDLKKEMRAIKGVLLSTKRFPAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTB5</accession>
    <name>A0A6A7BTB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTB5"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="137"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="46084" checksum="3D264081C53AE2EE" modified="2020-06-17" version="1">MPLTFCHSADPVTLSTSSGSVLLPQFVQEITPPCDLNPFLFNGHLQTAWTAYKTPGPPVHYKRRVFSSNNPSFPGTFAVDFVVSPPKPLPAKADDSQVEDVGLREDPTGVGHISLPPRTTYFTNEEFASLPSDDTKPLLITLHGLSGGSYEIYLRHVIAPLVAQRATSTQSTKGEANFGPSGGEWECLVVNSRGCAGSKITSSILYNARATWDIRQIVQWCREVWPNRPLYAVGYSLGANILANYLGEEGQSCSLRAAALVSNPWNLELSSYVLQSSWLGLHLYSKVMGENMKKLFLTHREAILSNNPEISEERVMKLRYLHEFDREIQGPTWGYPTESAYYRDASSCDVLLDIRVPTLALHAKDDPIAADAGVPYQEIERNPYIVLAASAGGGHLGWFELGGGRWHVKPVRTPPIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTH1</accession>
    <name>A0A6A7BTH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTH1"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="24429" checksum="19FB0B115FB74B59" modified="2020-06-17" version="1">MASQWLPSWFSSKATPDPAKDDDDAESTPKAKPSIPTLECPPLSLNSNDEDTKLMPPPSRPKPDRPKPAATSLSVPTTGPSPQRGRPGDSTQRAGKGLTPNRGKTNARGQVTLAPGHSPLDWSALSRSKNLSGVASLQRVKPSELRKMTGRKGKPAWSSWQGKVYNITPYLPFHPGGEAELLRAAGRDGTALFMDIHPWVNWENMLESCLVGALVPEESSTLDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTP2</accession>
    <name>A0A6A7BTP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTP2"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="419" mass="47284" checksum="65B1C9AC61518F46" modified="2020-06-17" version="1">MLTATLKRNLPPCKASLEPPTKRVHSSISKSRPKKYHCTEPDCGKSFDRPVRLTTHLRSHTNTRPYVCPVEGCGKDFLRTEHLKRHEKDKHSEIKNHVCGICERAFTTGTRLRRHEAAHERKKQLSCTECDREFRSADTLQRHIKADHEGQPCHACEECSRGFNSTKALGRHVQREHSAPAYHCSMCSSSPFRTYAELQVHLKSEHPATCVECGLVCDSNRALRAHVEIVHGMSGTKKAHPCPIDGCDRSFSKTGNLNVHVQNVHLKLREFVCGTFDLSNNAKVSGWDGMGCGMACGTKATLENHVRTQHLGLPNPIKPSRRKAREEKDGKKALSMLTGVGYEENKDIECLVPECQFRFTKDYHLGTHLERTHGWSIETISDEINTRRAYDGTWGVPIDPRLESDQVGLNGCDDELMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUD9</accession>
    <name>A0A6A7BUD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_200416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="255" mass="28652" checksum="BBBA4C9B29E27111" modified="2020-06-17" version="1" fragment="single">IHSHNDYTREIPLYSALAAGARSIEADIWLSGKDLLVGHSKWSLSKKCTLKVMYVDPLVEVLERGGGWVYPSRKGYVEGDETAGHERSKEETVYLVIDFKSTGPETFDALREELHPLHQRGYLTSFNGTKIVYRAITVIATGRVPYKSILSWKDGREIFYDVPILDLPSFAQDENHGLVSLSTSGNYKKMFGELLPLSSEHKAELHRVVASAHEKDLMVRFWNVDDSAWSTLTEAGVDWINADDFNAAISFLETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUF9</accession>
    <name>A0A6A7BUF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_296256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUF9"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="623" mass="68861" checksum="A3F18AE36A7ED83A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH8</accession>
    <name>A0A6A7BUH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_259401</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUH8"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="415" mass="46456" checksum="8CDB13CFB5451BA3" modified="2020-06-17" version="1">MAAADTISTSTIVAPHAQMPDAASMDDLTDSGDQYVSYKKLQRQLEYIRLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDNNTGIVQSSTGSNYVVRILSTLDRELLKPSSTVALHRHSNSLVDILPPEADSSIAMLGRDEKPDVTYADVGGLDMQKQEIREAVELPLTQFELYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQQDLEDAYTSQVKGTGEGDKFDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH9</accession>
    <name>A0A6A7BUH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_259623</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUH9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1069"/>
            <end position="1091"/>
        </location>
    </feature>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="24358" checksum="2B4F874FDB9579EB" modified="2020-06-17" version="1">MPLYRTFPGLPDSPDRPEGPVSPFNFLDPNDTLFGFADDEGPRPLFGDSLGQSAASWRNFPHAASGARTEPGKPYSMVDEVTTTTLSMMNEHADQAELARVDALIRAQKVPGYCILDDCLKYYTTTSAFKRHFYQHVKPFLCRGPDCIQRFANGNDLDRHRSSVHQQRCPGKKRYRCAECPEPVDGKKKVWPRKDNFVSHCKRKHGDKVNATVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV43</accession>
    <name>A0A6A7BV43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_107370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV43"/>
    <dbReference type="OrthoDB" id="3508922at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025533179" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="176" mass="19059" checksum="F21A4EA18257DDB7" modified="2020-06-17" version="1">MKLLNTLILALGLASASPAQDTYKAPSPSKPTPTPPVTNGHIPKGYKWHVTSWSAGCARHGCYYDFNVTGTADRGMPDFLAYCSGEDSGFFADCKLLKSGKRKDGPPSVAARLGHYDVEKADGKARLGVSLAFEERLSKDTLATWNFTGRYNATFNQFVAPLEEFYVTPNEVSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV72</accession>
    <name>A0A6A7BV72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">K470DRAFT_259115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV72"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="386" mass="42157" checksum="C35385CFFB0E3428" modified="2020-06-17" version="1">MSKAPEPDDEIVISRPEVVHWWVTGFPHSHGFPNPSWPSDDRFVHHYLSELQFFDFTTKNGAAFSQATSDLASWNRVHDRDAFEAALRKQVGTEYIIAGAAEPIQVKKTGPGANGTKFIAAGGTPGAPAPTAGVWVIRKQDRIVQDRRPDPDNPFPETDILETYYIVGENVYKAPSVADVVENRMLGVMTSLNAFYTKARSLPRFSPTKGHTYLTDEGKKNGKDGVVDLAGADERSQRSSSVNPLQQDAPAAAAAAAAANDDDEAWQDGLIAQTLRMCGQYEGEYMDENPITGEPWNFKLTSTFNAVKKKRADEAAATAAEALKKQKEKEKAASSRTVLPQPFTSGNATKVKDRQLSKEERRKRRKSRQGTATSTPVSTSASASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVM2</accession>
    <name>A0A6A7BVM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_249619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVM2"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Cannon C."/>
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                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33770" checksum="8396E5DE0978B210" modified="2020-06-17" version="1">MQPSEDEIVRCLEQVTRKALANNEEITVNSARALAVKELGLDQDFFKDGAWRSRSKAVISAAAQDPNSPQVSKSRKRESKEAFGEKKRPKKTRTPTSSTPRNQIDSDNDQGSEVGKHDGDTESFGRGINGGAGAMKFDNPEEEQAAVGDESDMSSLIDEPPRKKRQSRSEDPKPKGKKAAKKNKDMSSDEEEIKRLQGWLSKCGMKRVWGKELKKYDTNKEKIRHLKALLHDVGMTGRYSLDKAKQIKVARELAIDLEDTKEFNAKWGQAVEDESGNERGASRLKRLPPKGLVDIGDSGDEGSD</sequence>
</entry>
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            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_249864</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="82"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="183"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="22282" checksum="3EDB28760BBFAB72" modified="2020-06-17" version="1">MSQERDLHRALLRPAVIYTLRAAGFHSTKPTVLDTLTDLAERYLSLLASTTAAYTASSPLPREANLTDVRLALTDCGAIRPVAASAAEEAWAERLRGPAQPDLPRKQQEEDKADLRGVRDFIQWFDGPQFAEARRIAGMPVPSGDDFLCALRKKFAKTGDESRLVGTVLGREMEKKEEGEQRPPDILVSEWRPKNGGDAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWJ3</accession>
    <name>A0A6A7BWJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_300575</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
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            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="403" mass="45080" checksum="51FFA43FB30A930F" modified="2020-06-17" version="1">MNRPTTWTGFASVAARGLGLRPSLRPVVYKPVRNGPIKQYHSQIESVKSSEERKAARSSTSLRRVALEAQRSQSIIQRRGTRAHINPENAIRDVTAYCAAETYNLARAKQLMERNNFVVDPFNTSLYPQVLHVQLSTREAQQRDEGDIFIFPSGSVVTWNVTEELARRVVEQILPGAAENGHLKTLEAEDLEYVEDPTRDTSKIVGETIILGTKATKDAETAGDEQVPQKHGADVVLTKIAFSSALARSTKLAVLENLLSDYFATTRSIPSTLSAGSKLPFNRKFILQKTGQLLSLRAQLNLYSELTDALPDMFWDSPHELGLEGYYEQVGRALDVGSRINVLNERMDYASEIARVLRERLSEKHSNELEWLIIGLIAIEVLFECLKLWKEIGVSQQTQATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWJ7</accession>
    <name>A0A6A7BWJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31097" checksum="35B88BC540672F64" modified="2020-06-17" version="1">MSNQQIPNEAPPSYYQATGTRPQDPNHLGVPGSSNNSGIPTAHRRSMEDESRPLPPGWVRTFDPATEHQFFVDTNRDPPRSIWVHPYDDNEYMSSLPAQERDRILQESRHLPNRDDIIASHTDDEDSASELPPRPESSKKGFGRKFKDKMTGTTHEQREQKRQQRAQEEQRAYEQHMRIRRAMGEALRTGQPQCIGQDRQGKDIYIEPPGYGGGMGYGSGYGYNPYGSGIYTTPNARYVRPAAPYGRPYYGGYGGGLGMPLALGMGGGLLGGMMLGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWK8</accession>
    <name>A0A6A7BWK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        </location>
    </feature>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="14272" checksum="9492DD30F9AA8981" modified="2020-06-17" version="1">MSNANSPIVPSSNEPCSDKPAGGLSTPKQSDMPGQKVEACCIPTKSSAPESLTATCSGQSQSFSVKKPGTQDDGPQLGMWTYSTQEYEYEIIDLDKGDESKKSGDKFGGGNESDSEEDNEEGGVPIGNGKWKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX11</accession>
    <name>A0A6A7BX11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="22481" checksum="7A0B46B00F6A7173" modified="2020-06-17" version="1">MRHLRRTFATHTRRLEDVHNPNSKLPRVASTTFWSSLAPKPFRRPTNAAEAAERAQARAERPSFWASPYSTFAFLGLLVGSNAIQIIGLRNDIANFNRKTDAKITALREVIQKLRSGQDVDVKGFLSTDDTAAEVEWDQFVRDLEKMPDRKRDEKRSSEEGTDGGRLGRETADRKRNEKMSEPGRPDNDQPKPKFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX95</accession>
    <name>A0A6A7BX95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_271271</name>
    </gene>
    <organism evidence="18 19">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005988">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX95"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025459825" description="alpha-amylase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="34"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="58"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY46"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="29849" checksum="548CEDD3467ECF42" modified="2020-06-17" version="1">MVLEATMMVVDNSEPSRNGDYLPSRWEAQRDAANLIFHSKTQSNPESSVGLMSMGGAGPTVLTTPTTSASYILEGLHRTKIGGHSHLYSAIMVASLALKHRPNKSQRQRIIVFCCSPIDDDKDRLVKLAKRMKKNNTSVDVVAFGDLSDDNVEKLRAFNEAVKGGEGSHLEVVPPGPDLLSDIVISSPILAGEGSGVAAAAAAAAGGDGGENFEFGVDPNVDPELALVLRMSMEEERERQARQQREQEAAQGKTALESVVEEGQESSKKDDDDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYJ7</accession>
    <name>A0A6A7BYJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_258056</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYJ7"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="315"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="831"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="833"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2860301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134303" checksum="F176A63537C42671" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYP5</accession>
    <name>A0A6A7BYP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_295517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYP5"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="769" mass="85599" checksum="E87F93A204E4D6F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ95</accession>
    <name>A0A6A7BZ95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_286916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ95"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="37699" checksum="598C216DC621BCDA" modified="2020-06-17" version="1">MHVVEPQKGALICKQCLEDPSNLAKDDTKGDTTCGRCGIVLSERGSLNGPQLGTAHDNVKERENHARVDNANDPQYNNSDAPNPTAIGDGVNSPELPRTRNKPSKQNKSSAEKNSRGLTHAYKHITSLCDRWDVPNTVTDTAKHLYKESSESLLFRGKNQESLMAGCIFLACRQNNVPRSFREIMELTKISKKEIGKTFKLLESFLLQNSLGNAASGSVVSGGTAVPSETYKGSVAADPADLCNRYCKMLNMDQETTDVATELARRITSVGVLAGRSPLSSAATCIFMASHLMDQPKTAKEIMVAARVSDSTIRQAYKVLYHEKDALLSEKILDHEMHVSKLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZI0</accession>
    <name>A0A6A7BZI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_270701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZI0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22404" checksum="0301798B20B2C7EF" modified="2020-06-17" version="1">MPSQLVSSPPYLPPELIALIISHLTPRRQPIDSKATKREKVKALLSSTLVSSTFCEFSSAILWRFAPANAIARIPSTRRANHSRKLGRLVIGPVTEPTPPVDDGILFPRPPSFADTATRVHSALHGLPFPRLRTVWDMRYSCDGPFTFDNYLHPELRELELRGEYPPPEELKRVGLRCVKLEKLTFHPLWWTENPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZJ6</accession>
    <name>A0A6A7BZJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZJ6"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="16270" checksum="24C32035FC7D5485" modified="2020-06-17" version="1">MSDGEEPTSPVETGEVEVAADSGTKSGGMDVQEALKGVLRTALIHEGLARGLREASKALDRRQAHMCVLNDGCEEEAYKKLVVALCNEHKIPLIKVPDGKQLGEWAGLCQIDREGTARKVVNCSCVVVKDWGEESQERSVLLNYFNTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZX8</accession>
    <name>A0A6A7BZX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_246775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZX8"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="326" mass="35878" checksum="26A62814360F1F6F" modified="2020-06-17" version="1">MADGKGLAPLTWALLQERITTTLYSTEKFTYPLFLNTIQSLFASLLGFLYLKLTTPNVPILPTPKILPPLFLVAVTTSLSSPFGYASLNHVDYITFILAKSCKLLPVLILHTTLYQRRYPWWKYLVVGLVTAGVAVFTLHQNPSKKRKGSQGSSLYGLGLLGINLLLDGLTNTTQDEIYARFRFSAQQMMCALNMISTGITGGVLVVGPWLVETGFGRMLGVRDELGDAVGFVKRHPEVGWDLMGFALCGAVGQVFIFMTLSQFGSLLLVTVTVTRKMLSMLLSVVWFGHGLSGMQWVGVGLVFGGIGVEAELSKREKRKKMKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C029</accession>
    <name>A0A6A7C029_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein, ARP8 class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_282179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C029"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000201">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="692" mass="78021" checksum="9B555B4B960EB936" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C078</accession>
    <name>A0A6A7C078_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_74418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C078"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="16725" checksum="DAB69DEC16B57F0A" modified="2020-06-17" version="1">MAHRATARYQSPAFTLHFLFYHFSVLPLHSHIILVVTCDATLDRLTLHCTQRRSSTGLTFCSGAVDSETLYFVSHLGTKRKSALVAFSLVVTSEIPALDAKPGGCLCLSGFDVAEGSCHIQRGSSSHNGASASLPSRVDVQHVILLEYLLLCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0A6</accession>
    <name>A0A6A7C0A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_216484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0A6"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19172" checksum="CAC46F57EBC29448" modified="2020-06-17" version="1">MSYFFTIVSPLDRPLFSLTFGSSKPGGDGTAHFPADATAHWNEFLTHASLDLVEESMTTTRDLYLKRVDSFQNNHIHAFVTPGGVRMLLLMNAESANSASSYSEGKSAAPVTALGPNSLAANPLSQATEDAVKSFMNEVFEAWVKCIMNPFYDVNMPVRSPVFRSKVVNAGRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0F5</accession>
    <name>A0A6A7C0F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apses-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_247374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0F5"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1F9"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21584" checksum="B794DAAFDA66F215" modified="2020-06-17" version="1">MARGEPSNQQVSHTNEPGKDKSGNPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPAIGIYGMDFYCCMTRPGERVARRRRCKSRIGASHRIDQAETVKWFKNRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1G3</accession>
    <name>A0A6A7C1G3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_281587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1G3"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="106" mass="11485" checksum="DE708D76B9ED9335" modified="2020-06-17" version="1">MSTPGPLDLVDPADDVSTIDSLPSPTTTFSSSGSESDADAEWTESIRQLELLLTMVLVPLVGKYYGRKVAYWGWAKFMEWKFPVTVEIANPKSFKAVGAVEAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L8</accession>
    <name>A0A6A7C1L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_264392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="47"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="314"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="401" mass="43910" checksum="439C9097F44D96B8" modified="2020-06-17" version="1">MAVQQTSHPRFLSPATALSLTRLVLLPVAGAAPVWRRQTEPEPKSPEDASLWIYLSIAIVLVLTGGTLAGLTIAFMGQDETFLEVQRMSADTPQDQKSAAKVLKTLKKGKHWVLVTLLLGNTITNETLPIVLDRSIGGGWPAVLSSTALIVIFGEIVPQSICVRHGLTIGAIMSPFVCVLMWLLAPVAWPTAKLLDYLLGEDHGTMYKKAGLKTLVGLHKTLGTSADRLKEDEVKIIQSVLDLKDKPVGRVMTPIEDVYTLSVDAVLNEKIMDEVLEQGYSRIPVHATDKPTSFIGMLLVKTLITYDPEDCKRVSDFALATLPETQPDTSCLDILNYFQEGKSHMVLVSEQPGTDNGVLGVVTLEDVIEELIGEEIVDESDVFIDELRLDGRGEVVYGRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1N3</accession>
    <name>A0A6A7C1N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_35433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1N3"/>
    <dbReference type="OrthoDB" id="2447802at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17926" checksum="8F22D073E51FA5DB" modified="2020-06-17" version="1">MPTNIQEWTDGMKHFPGNTSDLSQVELKGFELALCAHCDKSTKDFSVNGFFRRCEVHFKRSVTTVAKNGSIIPAMETTSFRDLAWSLLPDQPYEDFRDEVEHMATTCLQIKPWLYWFVSWSEFIFKAMSEIRISGCRTRPISRSSSKGTSKGTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1R4</accession>
    <name>A0A6A7C1R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_257085</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1R4"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="394"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="458"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2861177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="734" mass="84038" checksum="467488B9BE53B751" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2A2</accession>
    <name>A0A6A7C2A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_191479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2A2"/>
    <dbReference type="OrthoDB" id="5424021at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9224" checksum="A7B169AC4FD798F3" modified="2020-06-17" version="1" fragment="single">PNIWILTSSPIPRGRCDHKGSFSLLTSCPCHRFMQHPARAGSTFLCDGCGHHACFHRLRNREGDGIAEREKLPRKRKKVGEG</sequence>
</entry>
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    </gene>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 480.64</strain>
        </source>
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                <person name="Ezra D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
            <begin position="85"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3J5</accession>
    <name>A0A6A7C3J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_31494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3J5"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025357374" evidence="7">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="336" mass="35977" checksum="2AE6AB1A85A957E6" modified="2020-06-17" version="1">MFFSVLLLALPALALPLDDATDATTANITERAASSPIMGGLNFPDPSVIRMADGWHAFATNAFVDGKRIHVQVANTPDFKNWNYRRGYDAMPNLPDWIDKTSPRLWAPDVNQLPNGKFIMYYTAAMASKPTLHCVSYAISDHVEGPYSSGPAQPWVCPTDKGGAIDPSGYLDRSGSRWVVYKVDGNAIGHGGVCGNTLAPIVPTPIMLQQVDATDGITKIGSPIQLITNGKWDGPVVEAPSLTKLGDRYVLFFSSNCFATTKYDVSYATSTHITGPYTKYGPLFVTGSRGMTAPGGLDIAVNGDHVIWHANIGSGRASFTGVLSMSGNDVRVISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Z6</accession>
    <name>A0A6A7C3Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_243810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Z6"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="232"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="440" mass="48978" checksum="CE70119CCC152EBB" modified="2020-06-17" version="1">MTFLYDVLQQGRRAVVQALNGASIEHDAPFSPDVPDDLREWLPDLFDRFPVVLPWARAEPVDPALHNVWIFDNTAFRTPQAGDHRPDLAKLANPQTTQPTSNGKPTRGGSGWEVEFVAAYFVKDSQNDLSQAVAKLVKALNIGREDIATKKLIASRLEPFASKILAHRTLRISIASMEEQTLGPSSLAGVSSELHELHIQPPDNKTVQSTPLDLPPPFGMSSTTVFAGETGWGLISDIDDTIKVTGSNDPVSVLHTTFAVAEPEPVTGMPELYAHISKTLRNPATFYLSASPYPLYPFLRDFERAHYPQGTIILRDASWQNLGGLVASLQEGVEKYKVDRLVKIHAWLPHRRFVCVGDSLQSDPEAYGEAARRFPGWIRAIFIRRVGTNAEKVKQERFEEAFRGLDRRLWHVFTDAGELSERIDELGRDDEALVGGEHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C440</accession>
    <name>A0A6A7C440_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H1 small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_30926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C440"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="128" mass="14214" checksum="970229651EFA1375" modified="2020-06-17" version="1">MWSLSSSQAPEQKVNLLPCSIKHDGPIQVPERLWSPCTGTDGDKTVYFRGRQLRGQSVKLPEGYEGAVLEKTDQAAPDCGEEDIKKMEIKGTFGEFVVWAHDALPSKEDSHVKAVEEWMGFAAAIHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C463</accession>
    <name>A0A6A7C463_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_21526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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</entry>
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    <sequence length="513" mass="56657" checksum="A1B03E90190E7DC1" modified="2020-06-17" version="1"> </sequence>
</entry>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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        </source>
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        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="583" mass="65344" checksum="BD226AAF56E62575" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="73481" checksum="3E1B8E7B4AC5D91E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6E3</accession>
    <name>A0A6A7C6E3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_211146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6E3"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="22513" checksum="5244A83EDF2D4F36" modified="2020-06-17" version="1">MASRKKILLKVIILGDSGVGKTSLMNQFVNKKFSASYKATIGADFLTKEVLVDDRLVTLQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNAKSFDTLDSWRDEFLVQASPMDPESFPFVVLGNKVDVGGDKRVVSNKRATAFCQAKGGIPYFETSAKEATNVDQAFEVIARNALAQGESQDFNPDFPETIPINIGDRDQGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6L3</accession>
    <name>A0A6A7C6L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import translocase, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6L3"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="15961" checksum="25903F95C0CB6073" modified="2020-06-17" version="1">MVQLEEVADEELTSSQPYNNRSDEDDWNTDDESVVSVSSDDSSVSSLEGETLADRIAALKDIIPPTYRKSLSNASAKASSTAKSVWSWSGNALWVVSTSALLLGVPWALAFSEEQQVIAMETEMRMQQNAQQMLTQGSGEQSAKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6S5</accession>
    <name>A0A6A7C6S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_211173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <authorList>
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</entry>
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        </location>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 480.64</strain>
        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="666" mass="73892" checksum="3DB84BBCE35CFDBC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8E2</accession>
    <name>A0A6A7C8E2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_202322</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2399539at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="54" mass="6283" checksum="9E2F11E1EB01A7D1" modified="2020-06-17" version="1" fragment="single">RSRVSRACDKCRASREKCDGARPCCRTCFIQKRECSYDDPAKKRGIQPNYIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8G5</accession>
    <name>A0A6A7C8G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8G5"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000037">
        <property type="entry name" value="L-galactose dehydrogenase (L-GalDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="414" mass="46345" checksum="6E7F79BC86F36329" modified="2020-06-17" version="1">MATEARPPLSSVLPPLIFGTTTFNYLYNEDPYELNADALVHRALEHGVRAFDTSPYYGPSEEILGAALAAVNHKWPRETLHVNTKVGRIAADRFDYSRDWVKQSVQHSLRRLRTNYLDLVFCHDVEFVSESEVLDAVAELRRMRDDGVIRYIGISGYPLSVLASIARRVLRETGEPLDAVMSYAHFTLQNTMLATVGIKQFQAAGVDVVLNGSPLGMGLLRREGVPVGSMGDWHPACNKLRAAVKRASDFCDVYDERLEVIAIRYSLEQWVLRGAVVGSYGDPASGVPNRRLSHDRSQRLGVSLMGISKISELDKTLKVWRSILDGLEDGEETARRAGRWSRDHEWSLNRRRAIEILADGIREYLDEFIDYSWPSPPVGFVNQAASLSAELPTPAMSLPRDDAPREEGKALPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8T0</accession>
    <name>A0A6A7C8T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_85348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8T0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="264" mass="29731" checksum="0961127FB0084CEB" modified="2020-06-17" version="1">MATTRALTGLILDSTDTLTLLQRLRDQITYTPTSLNRTASAITTSLDRLATVRRYLKLIRDEANEGFFVASRRDWDLFVPSLQMSLDDLLSIGERMREGGSARALWGLIASGMTVDEGVSLIDRLGVYVRFLRGEVGVLRGEEGEGKDVSRRDLVELVERQRGSSQRVVGRGVGALGRGRGRGREITEVSVQRFRSRSISTHKERFRSGSRRGLIRNRTLSPSTERKKHWISKVWDWSHPRTSFHDKHTMSAASPLPSLLILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8V6</accession>
    <name>A0A6A7C8V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_267883</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8V6"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="296"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2863870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="554" mass="60543" checksum="9FB503174395F250" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8X9</accession>
    <name>A0A6A7C8X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_240506</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8X9"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="468"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="790"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2863697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="942" mass="104622" checksum="A2488F39A8D80476" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9F4</accession>
    <name>A0A6A7C9F4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_267869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9F4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="115" mass="13603" checksum="F10814EF997E7753" modified="2020-06-17" version="1">MFRNFEARRVPWAQSWLFTMRVPTTFLEGLTMEELYWGQHYKEYVWVSRKQMRSRPYLRYAYLDGLHVMKGHILKGASQARTIDSVGVLGDPTTERLEEAIGQIIYIQIHTLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9G1</accession>
    <name>A0A6A7C9G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_225308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9G1"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="43161" checksum="B51CD896E821B403" modified="2020-06-17" version="1">MTANLAQLDASRLTRQLTKEPRPVPSPNGPEAWAQNTCTDHMIAVKWTAEKGWDAPELKPYGPLSIMPSASVLHYATECFEGLKLYRGYDSRLRLFRVARNCQRMRQSVTRVALPDFDPVQLEKLIVALSAQDGSKWLPPSRTGGFLYVRPAIIATDPSLGIQRPKEALLYIILAVFPDMSLSDLTDGPPSTGLKLLASDENTIRAWPGGFGYAKVGANYGPSLVAQGEARSRGFDQVLWLFGAENFVTEAGGSNFFVVIRSSESNKVELITAPLKDRIILEGVTRASILDLARERLQTSNDGVEAVQVVEKQYTMAELIEAKNQGRLLEAFAAGTAFFIAPVSRIHFRGQDIDIPTDGVYARTIRRWLEDIQYGRTQNEWATLVTEAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9J3</accession>
    <name>A0A6A7C9J3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_240088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2864063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="14755" checksum="70D8E8B66B47ECCC" modified="2020-06-17" version="1">MPMPSKDTRVATTADERGLTQYLWKWGGSSVPPSVLATFITAQHLRPFQTLPMLFPPVLLLSSYLNLQGFQKDAAGVTAAWSAAYMALASRRKLAIRQRFNVRGIVRGATMGMCAMNVVACGWVYAFGKRKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9U6</accession>
    <name>A0A6A7C9U6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_253961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="218"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="484" mass="50565" checksum="35932C8D45F0AE90" modified="2020-06-17" version="1">MADKDYPPHGTLDPAADSKYPENLLSSKGASTTHNSSSLGADIKSGLSSFDDSADGRTSLGSSGIGTTGWENDLTARPSGSSGLGHGTTGTSSLGGTGLDSGYGTGNTGRSSLGGSGLNSGTTGQSTLGGSNLSGSGTGRSSLGGSGNPFSSGTTGTAGYGSGYDQHPGSLSEGPVADKARREMNQTQNEFSNLANSRHTPHTPAATGQNLTHYHSFFYNLLNWSNPRATGITYVAIASFILAWRFLPLTRYALRGTWMVLGLTAAAEVAGRLVLDQGLTSKLRPRKYYTIPRETLETTMDDLTELINFFVIEFQRVLYAENVYVTIATCLTALLTYFLVKVTPAWGLALMFTTCLFFAPLIYLSNKQLIDTQLANGREIVRKQTRQVRDLASHHTSRAMAVSSNTMKDYSAKAQGALGQKTGSTGLAGSNTATAGKTAGLTGTQSTGSLSSAEEQLRGAPSVPSSDLKSALGSQERTAKPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA58</accession>
    <name>A0A6A7CA58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_267260</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA58"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="410" mass="45238" checksum="1B9C65DF75F2E514" modified="2020-06-17" version="1">METTFISIHDLTEEARILYSSDSVVDILGYTPEEIVNRSAWDFFPSSDLANARHVYQHRVATDKAAVLVYCNIRNKQDQWVGCEVVFTIVYDVMIVCTSTYTQGEASQRRAIDAPIIRRMFSSSPNDPRYHMLSHLSPKFQQDSAPELHEPRAALFLNRFTRTLTIMYATTGIQEVLGIPAADVRGRSFYFCIAENCLADAVRCLETAKANCSIAYLRCWFRDPRIDDYSPSVSQTHMSDPPLEIEAVVSCSSDGLVVCLRRARPMLPSVAGRGVFAAPWAEQPILPPFEHRQGFENTRFAPSLGPRSAQTPQQPSLQHQQDFLNAIRQQAVFAWAITGTNGSMASYARSKPLGGAVPPSGISVWENEAKAGGIGAQVDGSNDRKSGDNGRLTPQFFGDPGVGHGSGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAX9</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAX9"/>
    <dbReference type="OrthoDB" id="3906011at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28809" checksum="9DFB4115459CF934" modified="2020-06-17" version="1">MDRMGKVQESRRNFSFLPTLGFVSLIQGTWEGLLVSNYPGLLNGGRAGLFWCTIAVWILTNGSSASMAQMASTAPTAGGQCHDVLRHWKRDFWMRNACDLFVRPCFDLLHPTANSLLRFAITDVEKQIMNAENKVLVLFIIHSATNSKTGTCILGTVSIILCFFCTLTNVASSSRQVWASSRDHGLPYASVIRQVHPEWETPLKAHLICLAISLLLGAIHFGSNVASFIFVASFILTITYYFISGRHHYVPPVRLVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CC67</accession>
    <name>A0A6A7CC67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_284208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CC67"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18125" checksum="F5A5F3F2DE1BAF67" modified="2020-06-17" version="1">MTAATAPVTLPINNDTDGIGVASFPKPATDKPCDSWWLKGIGLLWAADLGYSWPVKNFVLDRLLDGYAGYPKTHGHGKTRKSHYALGGYPSGKEFRNLKRFYPYFQWLVEGKQGQCVCSLCASEQSHDVEDVAGDDDDDDAEFRKHVRDINFAVVQRSLKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP35</accession>
    <name>A0A6A7BP35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_198643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP35"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="169"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="37741" checksum="559D916E51FE4F94" modified="2020-06-17" version="1" fragment="single">KYYAVRVGRVPGIYETWEECAAQTKGFPKATFKSFGTLNEAEEFVKVKDAAEKWYAVQRGRRPGVYKNWGEVLEQITGFKNSSHCAFPTKVEAELFLRGTREATEDAEEGPRSKKAKLDEYPPGEAPLSTGASGELDANILLDPRSGGLRYKTGAELTRTKLAVTRPTVFAPVRIYTDGASLANGRAGAVAGVGVYFGPSDKRNISEGLAGPKQTNQRAELTAISKALEFSPKDRKLVILSDSMYSIKCVTEWCFKWRQNGWIGSLGKPVENKDLIQKIISQLEERLRINEGRQVAYENGTGPWERGPAGVRFEWVKGHNKDEGNEAADMLATAGARDARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP82</accession>
    <name>A0A6A7BP82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006064">
        <property type="protein sequence ID" value="KAF2857134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP82"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="12558" checksum="17CF641AF8A95973" modified="2020-06-17" version="1">MFGRQSTDFISEQTRIIELEFHERREQKMEADQEKRKLDWMANQERLDKAKHDIINDLKQQITQLDEEIKVIDEGHKAQIRELNEDHKEHIKKPEEDHKKRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPA8</accession>
    <name>A0A6A7BPA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_267013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006059">
        <property type="protein sequence ID" value="KAF2857201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPA8"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025332955" description="V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="211" mass="23652" checksum="F1A226CDEC02C1C3" modified="2020-06-17" version="1">MVRILLGLTAFTALATADQFFLYSTSPLSTRQAPGPNIADASEVETFISHEVGQCAHENYLFFTGNVSRLGGWTPKGDNRVEVDNVLGDVYMDTLRRDAARCGQVVDIDLNTWKGALKHMLDDLKGSYLLIYASQQGRTEPLREEVHTHLKRKAKETKKSLFEKYQFLTPVSLLLMMLMYVGISALANLKVSYEAFNKEMGPQAQNKGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQH0</accession>
    <name>A0A6A7BQH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_170612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQH0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="14749" checksum="1D40CED8373DB705" modified="2020-06-17" version="1">MIAIPSAKGRATKYELSLKEPAISIFSPTADVIHSSLLDPAHSELSGVVAESHKLLLHAIFTIQDRITYFISAPEQTHGHREGTAIFLENDESPPGLDGSTLFHLFFVGGSARGSIRLCDGTWLPKIVQTAALLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQQ2</accession>
    <name>A0A6A7BQQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_194383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006058">
        <property type="protein sequence ID" value="KAF2857217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQQ2"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
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    </dbReference>
    <dbReference type="Pfam" id="PF20669">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cullin repeat-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="630" mass="69634" checksum="B0BE3FF2E299522D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR49</accession>
    <name>A0A6A7BR49_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">K470DRAFT_208081</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="261960at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="175"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="387" mass="44038" checksum="F5CD2F596C5C1285" modified="2020-06-17" version="1" fragment="single">RTFPSEHNEQRPLFGVYEHLTSQPSSSSALLMLRKAASAVKPIMLKRSWRVKVLTEFLPRDNGLLGLNINHGEKICLRLRYNSSKSFLRQEEVIDTLLHELTHIVWGPHDHNFERLLRELRGEYAILRGKGYTGEGFLGKGHKLGGRRMPVEEMRRQARVKALEREKKRKEESDKKGRRLGGLPPHLVGNDTRRVIADAVERRNRMKKGCGSTWKDPAQKLAQEGTRGQTVQTTQADDDDGIAEALFELLQEEEGRLINGLDALPSEEEQLAWAIEESNKHVQGMGEVVDLTGDDDKEEQWTCGTCTLRNPLTYLVCDACGTERELVPREKKQKRDPPQKKQNRSLEASQIRPAPKTSLGWNCASCGTFMEHCWWTCSRCSKMKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR87</accession>
    <name>A0A6A7BR87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR87"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="21256" checksum="36ED668FFC6A203C" modified="2020-06-17" version="1">MSERVTTLELQFVNQTLEVEILKQELAQKNELLAKMGKMYYETSLKLPEANRHIQAEEKKWADADARVRREAPKRGKKDHTIAEAYATVNEARQAKAKLDEAEKAMEAMREKLATKDEEANLVKGQLAAAQQEITGLNNRPIYRANKLQIELDAGIQHEQESRKAVESQLQEVQKTLGDMKLAAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRA6</accession>
    <name>A0A6A7BRA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRA6"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="310" mass="34437" checksum="A18D72EC9CE3693D" modified="2020-06-17" version="1">MIVRPLRLCNAKSEAQQKLMAIFMPPSPANIGYIRRWLSSEGPPDTVKQDWEFFQFQKRLLDPIGSQVAPHYRPHELLSRPPRAQDVSLELLMASQAHLGHATGLWHPANAKYIYGVRGETDPIHIIALDTTAAHLRRAAKVVKGVCEQAGLVLFVGSRPGQARAVVNAAELAGGCHLFTKWTPGTITNRQHLLHRCQKKAVDNEDQEVACSEDELRDHGALKPDLVVCLNPLENYVLLHECALNNIPTVGIIDTDCNPAWVTYPIPANDDSLRSVYVIAAVLGQAGKEGRDERIRRERMGADGWSQNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRL7</accession>
    <name>A0A6A7BRL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_151604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRL7"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="76"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="568" mass="62161" checksum="7005939C3DB86EF8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY4</accession>
    <name>A0A6A7BRY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006032">
        <property type="protein sequence ID" value="KAF2857667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="58" mass="6524" checksum="C1188027E918D3BB" modified="2020-06-17" version="1">MTSCIFWIPEAVLNEGYEVLRSLIATLRCPRALKQSARLHADLGESNPTRATLTRTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS02</accession>
    <name>A0A6A7BS02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_237292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS02"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Atg17"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="446" mass="50392" checksum="1946217B49FF458B" modified="2020-06-17" version="1">MDESSESSVGSPTYLKEVPTLERLILHFIAAKRSLSCISQVQRAGELVNKSSCLVEEIAILKARNSFARKCIDKQLSVLDAISDGIEQSGEATKGEFNATVKSLDESHRKLERALNRLKETIVDSSLQEKDASSKTLFDFIDEQGHEAVVGSLHGSVDDFSKAYETWQKEVKRFESDIAHVRDVIFLENRPIYDDPRNLGELYSSMEAHAVDMASLLQSLTTHYDLCVTALKHTEGGGEAAKQAAAKLDSNAVEESLYGKTVPEPIDHDEKMDMLRVLEEDAEQVNDVVEEIKDHLSDLESQFTLLSSQSSETKRINQSLHSALEQFRQIKDKLPFYLKASTTFSESWSRIHGDIQQQREELAELTDVYAKFSESYAHALAEAGRRKRAEANMRRYVSKVQKELDLLYREDAAAREEFMAQVKDTLPRDIWPGAGEESVQWEVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSQ2</accession>
    <name>A0A6A7BSQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_222271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSQ2"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="455" mass="51888" checksum="4F2C0A509055EEED" modified="2020-06-17" version="1" fragment="single">DPEELRQSPPPPATEVSFPAYPASSPEPVQWDRQKHPPPDFQTLFLQIRKPSDILPSHLQVLNINFQPQCSIQEMIPLSPDGGSYIPYLSDIIRPLPREAPPSPPAHRMWEFEHRIAEISLDNDLAYRRLSRSPMHSDGVRLTHMARFFDSLENLGQHWDSSLDRYLKVDEFDKPVDESEDGREVYSGRRTSDGKSMPDRFRSETIRRLVESIARVFNCAVAQPRRPPQIKLGMMNLPIRQTAALYRFPTDHRRAREGHLQGPILAVQTRPEFDFASEGGDTRSELDLLRELGALLHLAQERSREGTSEVKPGAGKWWTSAPRWGGGVVNAENFPDHDAKKPNTWATVKCGSGNWDPKTEYLALGKRRDSAYDEVFLVSAIVHHVSIVKLTVHDEYIRLLSSGMLLPDNELEDLPKDWCKPLFQRTGWYNLLDPGERSEAYAAIWGVVSYLMRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSW4</accession>
    <name>A0A6A7BSW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_251767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="233" mass="26200" checksum="1EED1F3BD744326D" modified="2020-06-17" version="1">MAGNVLFGSEIFESLQKKIDEDTAVKDILHDVAQALEKNDRATQAILSRVHSTPSHQRRMIVEQAESEIGNEIATLQDLSKIASRYPYYKFSHAWTRPVQDACLSILFCGWLGGFGQDKVGKLLTIDEVGAIMKVPVNLKDKDAFHLTIEEYLLALLSLLDELARLARNSVTLGDFNLPQQIAQFIKDVHSGFQILNLKNDVLRKRSDGLKYRVKEVEDVVYDLSLRGLSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT73</accession>
    <name>A0A6A7BT73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_266016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT73"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="190" mass="21297" checksum="69608553B2A881DE" modified="2020-06-17" version="1">MMRFFALDHEGFKLIFRVFLASRFPGVLHPHCRLIHLAQQAMLERFLAGGKHGLDPFSSESVPYSTGLAGTSSATTQGISRSGFWLEWAASSITDWRMPVIESSPQDPYTRENFQPVIDAFASVNLAINTHPRSALGFAKNLVKVLPTIKLLAILSFDRLVIGCIFHRFQADSSKAMDKNFVMMKEKVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTX5</accession>
    <name>A0A6A7BTX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_278384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTX5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2858634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="450" mass="50008" checksum="2FB6422440B578C3" modified="2020-06-17" version="1">MREVVSLNVGQAGCQIANSCWELYCLEHGIQPDGFLTPERKATDEDHGFSTFFSETGSGKYVPRTIYCDLEPNVVDEVRTGPYRSLFHPEQMITGKEDASNNYARGHYTVGKELIDEVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFCVYPAPQVATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPNAENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYSPIVSAAKAAHEAHSVMEISINCFEPNAQMVKCDPRNGKYMATCLLYRGDVVPKDTHAAVAHLKTKRTIQFVDWCPTGFKLGICFQPPQQVPNGDCAKVNRACCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSGEGDEGVETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ9</accession>
    <name>A0A6A7BTZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_272626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTZ9"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27543" checksum="B935E7814C79AFC5" modified="2020-06-17" version="1">MSTMMSTRLGLWPQRTVICSAVSAASAASASAHCLAQQRRLSSSKASCPPASSNGPPAKAPSAAAPGRPRTKYAASLPRAPDVQHLNRHQIEIASFFALHRPISVTSAIPAPASNETFHSIFKARKRSAVAGTGDEAPQMHSRQVESWVAQLPPFQPPHPPLPESELVQLSPEVENKQQQQRRFRATFELVETTSEDGHTTYTATSWPTEVDMQLISVRRQRKLKMKKHKFKKLRKRTRTLRRRQGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU01</accession>
    <name>A0A6A7BU01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PALP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_220444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU01"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="10756" checksum="FEEEB96CE7E5EBF3" modified="2020-06-17" version="1" fragment="single">MSFHLRTLPKHLRPLTTQSLAGISPTLTSSIGHTPLLRLTHLSRETGCTILGKSEFQNPGGSVKDRAAKYLVSRAEARGALLPGGTVVEGTAGNTGIGLAHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU09</accession>
    <name>A0A6A7BU09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU09"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025569091" evidence="8">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="6"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="435" mass="45684" checksum="C138CA5820993659" modified="2020-06-17" version="1">MALLASLLIATIGPLLFGYHLSELNAPQHVISCRSNKDSGDCIPMSAFQFGLVTSIFTLGGLIGALSAGPLICRSGRLWGMKYSAFFATLGPALEAMAPSIAVMASGRLISGLGAGAATVIVPIYIAEIAPVGRKGFYGALTQIGVNVGIFLAQLLGLFCSRGGLWRVILGVGGLISLMQGGALMILGTESPRWLTDNGKLEDAKSALQRIREPSADIEAEIRAWKNCSDEEQPLLEEPPEPPKTSTALDVLRPPYLRTLIIVVTIMAAQQLTGINSIIMYGVGLLSDILAASSGLLNLGVAALNILLTSASAPLIERIGRKKCLLISIFGTGLSSTLLAVGMTRYISILSAIAVLVFVASFALGLGPVPFLLASELVEPEAVSAVQSWALAANWLTTFLVAQSFPILHSELGGNVYFFFAASAGVFGAFIWFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU66</accession>
    <name>A0A6A7BU66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_283130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU66"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51103" checksum="14C21F9488F4C7DA" modified="2020-06-17" version="1">MSCSDNSRVDHLLDQLERNLKHDGMPIKEQETVLGELKILGRNSASAGSIFSRRGIDVLAKYGFRRETKSTSHEALRCLANAFLLSETTRQLFVDLEYSTDAAERLKSNDCNDEFLISRIIFLLTYNTSADLDDMVNKHGLADSVNRHLTRHAERLTQDQTASSSMKDMALTETLKLLFNITYYRPHTSTNFTPSIEPIISLLVHHPTLSPPLQPPINYLLNALLNLDLSSAVMPDQDTNSTPPSHTENVIDKLISIFDQSIRSYPERELDQLAAPLCTLIRRWYELTTSHQKSNIRSALLPQTQDRDKPLGQGDSLSARLLRLSIAPGLPTLRENISCLLFELSDKDADKLIKNIGYGFASGFLMSHNIPVLASKDGTLQGDDDGVEINPVTGQRIAEETMDQPDSPEMSQEEKEREAERLFVLFERLRATGVVDVQNPVQKAVEEGRFEELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUE1</accession>
    <name>A0A6A7BUE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_192565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUE1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="26345" checksum="5574A32548514D63" modified="2020-06-17" version="1" fragment="single">RGISVGDDALIASHNFLGANDGVGAWATKQNGRAPLWSRLLLHFWAAAIDTDDGTDGSAAPRLLQSAYDITKEGLAKGGWLGTTTTSLARLVNNGAVAELEVTHLGDSKIMLIRPVAQEPIVFQTAEQWHFFDCPRQLGTNSPDTPLVNAVVTRMAVKEGDVVVAMTDGVTDNLWGHEVASIVAEREESNSNGDSVEDTALSIVTAARNVAKDPFALSPFMERAVEEGLAAEGGKLDDISVVVARVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUG4</accession>
    <name>A0A6A7BUG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUG4"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="395" mass="42880" checksum="997AE9781D767BF9" modified="2020-06-17" version="1">MSASRSLFARELGRDALSTFQSKTSDRLISLLQPSPAGPPHHHRGVNSIAIDPLTGSSLLSAGADSSVALWDLYGANAPVASNPRTTPDPPLSINKVSYYPFDANAFLLSCVDGSVRFCETERLAPRVTFPLGNAVNSHDTSAELSVACALAAPVARLVDLRTGGSTHTLPHSRGEVLSVAWRPQRMCVLASAASDGRVRIWDTRRADAAVAELDLEVWEGREGRNYASRAKAHEGPVNGLAWTEDGRFLVTVGKDERMRVWDGGRRFVNTLVHFGPRVKDEKRGVLNPVVAPSWTGANYVAFTASGGLEVFDLMSGTSVKRLFLPKMEGRIMDIQWRTGSVEVYAAHGDGTIRMWKPEAGGDESGKKRKRDDGDEANVLEDIVRGLTEQQVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH3</accession>
    <name>A0A6A7BUH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_207422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUH3"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="286" mass="32665" checksum="2721B91EA06BDCD6" modified="2020-06-17" version="1" fragment="single">ASSMTEAATMEIHNHTRVSSASSNAGSASAGTSVCVICASDITHYSVGICNHRTCHVCALRLRTLYENKTCAYCRMETEVLIFTKDASKKFEDYITADIYQTDNNLGICYENVGAYISTTQLLRFKCPHANCEAACKGWKELARHVQSVHKKKLCELCTKHKKVFVHEHELFTDAELQEHRCYGDDKPRGTADEKGFQGHPFCKFCSCRFYDDQALFNHCREHHDICPLCKECPVAKDPVYLIDSAALERHFREDHWPCQEQPCIEKRFIAFGTEDDLRKHEAEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUS3</accession>
    <name>A0A6A7BUS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUS3"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="382" mass="40582" checksum="5042CD4CFA5CC0E6" modified="2020-06-17" version="1">MSHPCALLLPRPPSTSTSCAPPPAMLSSPAAAPSTATVPSGPPVCSATSAPSAPAPAPASAAQSAPPSSAPPAEPSRHGSPDRAVKKEPASPSIPARPRPKKLDLSRPPSTRPSAPLTAAIQDVGLACLSPGFQTNDPGLRSQLQRSLDVRDQQRLIIEARQRGQKVDERTPASSRRRGPPAGLTINAPSAAQFAHDRVIQSAPMNQTFTGLRPDDALTRNRLGQTSHMHHVPQPTTTRLPPIADVFANDRFEPPAPGPVVQPSPGLPPPLSLAPPRREYRSAEEAVRDLSGGREELMPKVVHYGGVQPPTPPSPMPPGHQRATAPTNGRVRGREEYERDNGSPPSSWNRSGAKRASYGMSNSERKDEFLRLCSQAWDLFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV80</accession>
    <name>A0A6A7BV80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_259813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV80"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="557"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="663"/>
            <end position="722"/>
        </location>
    </feature>
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            <end position="512"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="722" mass="79436" checksum="3D27EA78E57E6369" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF1</accession>
    <name>A0A6A7BVF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2858709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15160" checksum="3E7A1B79007849C9" modified="2020-06-17" version="1">MTTGSIIQWYKQTSFTDPVSEQRVTLDRGKFARFHHDQIGKVERIFTHRDPGGDARIFLCVIDTVSHPCGQFDMITGRPLRQIVAMDPRIIGLPAAHSKRLDIITIAMDDISGAIEEQADSSDLLHVDWNIQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BVJ6_9PEZI</name>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Sun H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
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    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
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        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
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    </dbReference>
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        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="390"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="497"/>
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    <feature type="domain" description="SSD" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858997.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1127" mass="120939" checksum="3BB842FD79EAD93C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVU7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="6">CSN7 COP9 signalosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_234602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVU7"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="28683" checksum="7C3B8E8BFD8364D2" modified="2020-06-17" version="1">MADQSSALNALASFIALSKTATSARAAAELIERATSDPNTFVFGELLQQPNIRALNDDAEYRAAWEVLKVFAWGTWQDYKATPGLPPLSDAQARKLRMLSLITIASEKSPSPDAAQHLTYLALCTRLDLSSFTELEQLVIQANNAGLITCNLDHASQKIVVRSVAPLRDLAPGSVKFMLSELSAWSDRNESALAELESRMNAIKKNASKRARQQSRAEKQLQNALQFENPMTKASSSRQPEVMDLDGQHRNSSKLEAAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVU9</accession>
    <name>A0A6A7BVU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVU9"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16291" checksum="328895BA5549BAD6" modified="2020-06-17" version="1">MAEAAQEEPFPARSRTVAGSVKDKATTVTTLSFSDKLLITITQNDKLSLWVHVPLSYSSTGEAAATGLVEDLSLSAKGENVLLPRLSLTATTVLGGTKREDEMVAQTLAVNLATALLVKDPKDGRLLVVGMGLDGAMDKEGFDEVVGLVLDCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW88</accession>
    <name>A0A6A7BW88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_112828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW88"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="212" mass="23736" checksum="E7DE4BFD82DC495B" modified="2020-06-17" version="1">MDCCRQCLDNPQHTVPLNEWEAVQGVSGRCWLGLLNMKEFLPQLRQGRNKGRQSVLMYEPRDRHCRACYAQRQRMQAKHKAAHLLTTPLHLHRHGCIAPRAACKSSLRERALAHSPASPTQLFLSGNKQLGLKRDASKEHLCAQWTGRPIRRKTIGSSPSLKRNMCACLRVCVCMCGHPNADIVNGICPGARLKPWRQNACIATKVACVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWL7</accession>
    <name>A0A6A7BWL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_258997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWL7"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36514" checksum="33F4CB20C0CC3B4A" modified="2020-06-17" version="1">MDEADGDSPSTQLKLNVFHSLVDSLAIRRPILHHLNADSSWLLQLPVPTSALLNGSRGYYNILLDPWLSGRSTTPWLNTQEHIIPSAIQTISELEELAREVDLLTPRPAPRRRSHLFRDDAGTFLDAVIISHASPDHCHKPTLLHIDRNVPIFASPPAVQLITSWNHFRTIISIPGAEDEDWKSYSLPPLPEWIGIARFAPTGDHHSAIAVFFNNRCCEMDEEECEAVFYTPHGISASCLDYLGDLRPRVHILALLHGVDKVGFGPVTVQLGMGNGGLLREVLGAKYWVPTHDGGKIESRWLRWLGWRVRGDAKGVTHVGNGESLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWT9</accession>
    <name>A0A6A7BWT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <begin position="126"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <cofactor evidence="1">
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        </cofactor>
    </comment>
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            <end position="24"/>
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    </feature>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00155"/>
        </source>
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    </evidence>
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        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2859901.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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    </reference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="6012" checksum="866F0D36F90AAE82" modified="2020-06-17" version="1" fragment="single">ELFNLRYAQLRGAIKRCFGVFKRRFQIFDAAPEFDTGIQIKLICVLGALHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXN6</accession>
    <name>A0A6A7BXN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
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        <lineage>
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        </lineage>
    </organism>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYA3"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="764" mass="86955" checksum="340B62CE63FAEE05" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ79</accession>
    <name>A0A6A7BZ79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_294860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ79"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025367246" description="Cell wall protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="51021" checksum="35D9EBC4A68D995B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZQ5</accession>
    <name>A0A6A7BZQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_258123</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZQ5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="181" mass="20925" checksum="91C7E5078C71EB77" modified="2020-06-17" version="1">MLSILRKARFKDKEMRILMLGLDNAGKTTIVKRIMKEDVHSVSPTLGFIIKTIEFDGYKLNIWDVGGQKTLRTYWKNYFEKTDTLIWVVDATDRERLGDCRQELAGLLPQERLMGASLLVIANKNDVAGCMTEEDIRQGLQLDRIHTHKWHMLHCSAMTGEGLQEALQWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZQ6</accession>
    <name>A0A6A7BZQ6_9PEZI</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Ramirez L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18804" checksum="E65ED7932748CA29" modified="2020-06-17" version="1" fragment="single">PSQVFNQQDHKAQFVSCLVTTTTDLVQHIWPNSANADPLPLDKFIEEVLRRSRMSYSTLQTALYYIADDEDNHPHPQQKRPHQKQLPSPLLCGRRMFLTALILATKYLQDKTYSLKAWSKMSGLRIAEIVALERLFLQTVQWNLHIPATKFRCFTSSILKYT</sequence>
</entry>
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            <fullName evidence="5">Uncharacterized protein</fullName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Ezra D."/>
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                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="324"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C052</accession>
    <name>A0A6A7C052_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C052"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="475" mass="52673" checksum="0CD1847E58037263" modified="2020-06-17" version="1">MEQDVSLHLHDGNFAEDLSSFDFLNGDTSSLVNTSSVEAGHKKRKSLGDHVSGDGGSIKRQDTQGVAKVSKKPGRKPQTDVPATKRKAQNRAAQRAFRERKENHLKNLESQIAELTKLHENDVRVNEALVAQVKSLKDELNEYKRRSLPLQSPTSAASRPHSYSENGGFLPFPDLNLDQYFGEQVPDSHLNFADPTGDFQDLAYPPVVTVPETGSHKQSLGSTGEFLELFVDEAFHDDSYHDVSNDKSPHQDGTLKSRGNSSSDDSRRESLSECPTGISNPGENGPATPYVKHTPTAAPVDATIDDFHVPSLDSFDPALFANYRDPKQDLNFDLALSNYNWDDPAINALPLYQSDIFNGALPSMPSAPSADLISQVDKARDGLIDEQKPRHPELKSRLDNRENFVSCEQILQKINSIKSDDLDINDLCKDLRTKAKCSENGMVVDKDHVKQVFDDYSSKNKFAFGNEGYENVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C058</accession>
    <name>A0A6A7C058_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_264503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C058"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="21185" checksum="0C32BBA40AF0E1AE" modified="2020-06-17" version="1">MACPLPELCTITIVRILNPTRTPSSTDPPFVTHPVQEPLSKSHDLYRTIILQAISYNAPPLTEPPKPHSFDLLCQVNQQSIPSAETGDHHTQKANSPPRQQHICPTQVTSLNPQPCNVPTNAILQLEYLQSQRQLIKTCSRKPSPGRGFIRHGIGHLQVRGAPSFESELVCKLAVLRPVSTNPPGLDHSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0A4</accession>
    <name>A0A6A7C0A4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0A4"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="208"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34208" checksum="F2C0882F87AAE212" modified="2020-06-17" version="1">MPDALSKTVPIWICVMNRLLFPHDEEASVLHTPSSVVSPSEHSQIEEQMSRFVQNAKSLALDIGGLKTKLGTKPMMPLWVTPRWMEGPDISSKYNAIILYAASSCVSEPLISLPYIQGAGDDSENWACGLDAATFWRHQEKLLTTAEDDLARVIHELISQSQETEFQEPIAINVAGNVHIATNAAAKAVSHQYSLVISCGPDVPFQSHQLDLSSGKVGSRKLRTELAKLIPLLPILRKNTTKTLVTCETGRDLSIGVCLAILCLAYSDDGTQRPNTVLNKTAIKQRLSWISTSFPSASPSRTTLQSVNAFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0H0</accession>
    <name>A0A6A7C0H0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_232362</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0H0"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="453"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2860425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115919" checksum="4E5A92C95B0EA37F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q1</accession>
    <name>A0A6A7C0Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Q1"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="539"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="860"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1051" mass="114890" checksum="E338906078ADFA1B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0W5</accession>
    <name>A0A6A7C0W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_215701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0W5"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="209" mass="23814" checksum="AAE51CF3CE709F09" modified="2020-06-17" version="1">MPGSITLYFDIVSPFAWLAFYHLTRSLPASATLNLTPIFLGGLMQMTHNTPPIRILNKGAWTEKERKRLAKKYNIPIAEYAPKNFPPNTLKAMRALAAVPEGKLRECVEALYRRIWVEGNADVQDEEVFGRILRGVLGDDEGKRVVERSKTEEIKELVKKNTQKAFDEGAFGLPYIVMEDDKGKRDAVWGFDHVDLVWEFFGEELKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L6</accession>
    <name>A0A6A7C1L6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L6"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025375812" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24840" checksum="94793A8669C8345C" modified="2020-06-17" version="1">MARLFIAITLLSSIVASLPTQACNASPTLPLGEVANSGPSPLPTLSGPPKFIALGLGTQNYTCNSTTGNYTSTGALARLFDAKPYLTRNKNEVQSLPRAYLDRYLEFPCSQQPSDCSEEDEQCEELVNASFQPLSLRVLGEHYFDSAGVPTFDLYKGQGHPLLHGKKTGESPAPSKEDVHWLYLTCNGSTDDRVVSSVYRVETAGGVPPDSCSGDGSIVVPYAAEYWFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Z9</accession>
    <name>A0A6A7C1Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Z9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="71" mass="8168" checksum="A6F3E240A6C085CA" modified="2020-06-17" version="1">MTNPLLTVPFYTVYSWPSRRNEQHTHENLCLVFSAPFHSAPPPAMSQRPSTLPRLTPPNQLPQRSIIRQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C247_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2" key="1">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="68" mass="7637" checksum="4514EB9237F68D68" modified="2020-06-17" version="1">MVPLILIHSVFGSSFLGAVLDLFKSIRGRVRGIASRASKLSLRWLLSETCTQREQENDPSQGKLPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C0</accession>
    <name>A0A6A7C2C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_216319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="27503" checksum="F03FEA93C1BC0431" modified="2020-06-17" version="1">MDSSADQSTPSLNRTPTKAPKLQPANRTEPKASIQPDKGSELGPLGSPQSTNSLDFVRRIRPAKTFQAQDAEKSVEAQKAKKAAETVENAEKYQDLSELPIDIRPPEPNSTATKFITHVTSSLDLLVRNEQLSDIYKPVNVARRPRLLERGHWLMVSDGWPPKLQCQFWLFLVNFVGQGKAGWGVWCRRETQSSSDLGTVKVYCWGELVRHIYLLLYVASNSKVKKLGLKWVDAEGKVVVEMQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2E4</accession>
    <name>A0A6A7C2E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_256773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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            <begin position="104"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="16271" checksum="BFDA745378826531" modified="2020-06-17" version="1">MIAEADTETFKKWVIANLEHIADADSDILADYVLALVSTNEPEPIAKANCVAQLSDFLGNKTGSFVDKLFAAIRSRSWDPKQQQNVQAVQTAARANAFAPAQGSKRTLQQAGDGQSMQQLQTVDSNGRPKKQPRRNDDRGQQNGQQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2H2</accession>
    <name>A0A6A7C2H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
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    <gene>
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    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
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        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02752">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="178"/>
            <end position="333"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="44180" checksum="E0DE9F4424B1B278" modified="2020-06-17" version="1">MSAFVRVSGPANENFVIGYPGVDATKARIVGTVEIRPRDGVTAPVLISRVDISLRRRNSINRTVDSLFQLPTARRDTTHPVCHELLLFKCAAGRESEPVYLMDLPFVLFLPNGHDTPPASLQLEKRAAETYYELVVTVQQPVTDMRRNEFLFDVPIRRYNTLSSFGMYNNPKTGEETADHLVKLSVNLPRWSYGPADPVSVYVQLTPNPDWLVRARKVKVQSITVSIVEETTYDRGDEAKLYSKDLARQEHQVKANLSDAGYSTNLGLVFPEKKLRDSDGLLPRSQRKFPMYAVSGFTTITDLYRIDYYLSVKAKLSSSRDIVLRMPIDVCPFDRTRCREELDAISQSVKEAEAVDIARPRAPPPTIIRADDPSGLLALGFAMVGSEKRPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2N6</accession>
    <name>A0A6A7C2N6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_294407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2N6"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="107"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="488" mass="53745" checksum="79CEB710C13CB344" modified="2020-06-17" version="1">MSDEHPRRRSSSTHPAPTFAKFPDLTHEQLHTPFEEYEDAPPLPNGIPTLHSSERWPVRKSRHGGGAGRGRQKSLSEAIHTVRNRQASITENAHEIAESLKAPVSIRLVILCCLWFASSILTNTSSKAILTALPRPVTLTIVQFLLVSFWCLFLSAIAKHNRSFREAMPVLKNGIRKPSREIILVTLPLTAFQIGGHILNSDAMARIPVSLVHTIKGLSPLMTVFAYRAFFDIQYSLPTYLSLIPLTLGVVMACSASFAGNLIGLAYAFGSAILFVTQNIVSKSIFNDAAQAEADGAPIQRRKPDKINLLCYSSVLAFLFTLPIWLWSEGLAMAADYLQDASITLTNRPGSLDHGRLALEFLFNGTFHFAQSLLAFVLLGMVSPVTYSVASLIKRVVVIMFAIVWFGSPMTTVQGFGFLLTFLGLYLYDRTVERKPTKRRIDPLLPLTTGEKIPIDGTLPPGTKAQETWSSQDRHLSVPQHLPASGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2P7</accession>
    <name>A0A6A7C2P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_215431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2P7"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="46049" checksum="78742E4702ECFE51" modified="2020-06-17" version="1">MKPFLRLHRPPPRFLQESQRWTSSKTTPSPSTPSSNLIIASAVGGAFLALSTTLYYTHTPISLESNSSTTLATQDATSRYTSGVTPTSSMRLRMEDFIYRTQHTIVSALEKVDGKKFMIDEWKRPDNGGGGTSCILQDGNVFEKAGVNVSVVYGKLPPKAVKAMRANHRALATQPSSEEGEREFFAAGISLVVHPKNPFVPTVHLNYRYFETVGPEGEVAWWFGGGSDLTPSYVFDEDVVLFHGELKKACEKHDRGYYPRFKRWCDEYFYLPHRGERRGVGGIFFDDLDGSEEEGKKDKEEIFAFIKDCAAAFLPAYIPIVEKRKDWTFTEREKVWQQIRRGRYVEFNLVHDRGTQFGLNTPNARVESILMSLPLTARWEYMHAPQNGSREERLLNVLKTPVEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2R5</accession>
    <name>A0A6A7C2R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_30779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="7906" checksum="07CC6D85347200FB" modified="2020-06-17" version="1">MHRTCLVPVEARCGVMAAWGLLAASKRKSILSKMSSMLCGSPRCDPQVMTHIPYQGSSTQKFSCVALDTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2T9</accession>
    <name>A0A6A7C2T9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_35295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10835" checksum="38A5E9A72CC19129" modified="2020-06-17" version="1">MDPISLTGHIIPRAKQAISALGRCFRCDCPGHFATQCIRHPSHSAYHHRYFRRVEQQNGHKPSVLPRRWDYRGPTGQTCHAHTHFHYQPFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C321</accession>
    <name>A0A6A7C321_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_202062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33220" checksum="2FC6B01CFCAA43B4" modified="2020-06-17" version="1" fragment="single">NLKSLPGIWHIRVLLGLLRQLFFPQKPQKILPPLSIFYPMITHSRTSLWETDYNFHKSNSTYFSDFDIARSQLLGYLIREGLERLNRGDETGLPAGSKEGKAYSFVLGSVSAFFHREIAPLQRYAIVTRVLAWDRKWLYLVSHIVPPEKAKGGKYWLQPWKKGKEGAGRAEGKDVLATSVARYVFKKGRLTINPEVVLQRSRLVPEKPVGVGLPPRGGEGIGKSSGDRNSNGDGDGDGDGDGDGDVNGHVDRDVQTGDDPWETMEKERLRGLRLADHFEKLSACQGECITENILGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C330</accession>
    <name>A0A6A7C330_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_25768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C330"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="23071" checksum="DDC2FDA97A09100F" modified="2020-06-17" version="1">MSAPNQSGKQGNVPSSSSSIVSSNTIPVAPSPGPTRRVVRRVMHAPSTTGTVPATPIDEEKPDSSSVAPEDTTSPTAPEAPVDTPPVSSVRRIVCRSASYVPSISETEYTEASPAQKSRLPSIARESINPLEAVHAKFIAQWFAENMGGDATYSEMIQTTVEENVVGTDFSQSVLSYIRSRLRESTGYDAYDEFQQPESGTTAWCKKSFNEIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C343</accession>
    <name>A0A6A7C343_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C343"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28774" checksum="19BEB992EC3C2EFF" modified="2020-06-17" version="1">MVKIILFGATGKVGGEILDRCIANYYVSRIICLTRRPLDQKYVRDPQARAKVHEIIHTDFNEYPEELLQRLKAEGAECCIWALATKIDMNNYKKLEDAQEVGIRYPVAAAEAFSKTLATALSPQDMPKKKFPFRFVFISSWGAEQDQFRPLWVWNDSRKIKGAAEKALFEIADGSLLIQGHRCFEVIAMRPGQIIPGGTALSTLIWEATVPSCAVDQLAKTALKTAMMGTMRERERIMENGACLGDDWAMINSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3I5</accession>
    <name>A0A6A7C3I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3I5"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="21986" checksum="52F8FBBC5FF2C271" modified="2020-06-17" version="1">MAFYEIQHHILLTSSQQDELAEAITKIHADQFGAVKQFVRVTFTDTSNTRSYIGGEQQGENRIVARVRHGQASAGQDWDQVCAQISAAWQSVVGVGLPKVRRSEPDQDTSLGSVIVEDSVMGGREIGIPVHRNQCDAEWMNENWEKLEARANDGDEKCQKVVADARQRQLLEGKFGWESKEAQRRLEEYLGWGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3W2</accession>
    <name>A0A6A7C3W2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3W2"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2861947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33744" checksum="487A0D51E94D2F59" modified="2020-06-17" version="1">MRCNVDILKPIQIGITIWSPEGDLPPPQLDPALIEELGGDPKKSWPPFLPCSWVFNFQFSLSDDLHSQPSIEMLKEAGVQFERHEAHGVPLHDFGAALTSSGFVFNKDVNWLSFHSGYDFAYLIKLLSASPLPKTQEEFFSLVPIYFPKLWDVKTLWREIQRRKTCGRLGVDATHIVEAVGSKSGLQDLANELGCKRHGIQHTGGSDAWLTGTVFWAVRQKLFNNDIDPKLSDQIYGLHNVQAPANPQLRDEFLAATQGQTPSQVSQSYNPTTAAYAPSTPTNSHTAPASHTTPGHYLGSYYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C464</accession>
    <name>A0A6A7C464_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C464"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44949" checksum="9AD766457389E0B4" modified="2020-06-17" version="1">MELVLDIVGNLHPENDRNTLAKCSRVNKKWADVASEVLWSHPQYTAFARLSPARKKYYAPLVKPLDVEEDLPRHLYVATSRLQFPKLRTITFTLKLRQNGTLIPFKQFFKPTLEVIRFNGLMELGKILHTIPVKCPDLKELHLSRLSAHWRAHMIRDLVAKLPQLEAFSINGMPGGNLLVAPIIAAIADNHKIHTLSLKKNLTETGADQLVAQALARTTSFLGLKNLNINLEGPVVARVPHFAQHVRSLTLHIHYPDYKVFDAAEAMPKLQSLAIVHGRHPGPISRMDLRKLHNLKSLRYLGLRAANSVSLRPQDLTALFYSLQQLKEFHWLVPTPNAPSADIFIELGRHSQSLRALRTNQPFDLLSLYRSAPAPYFPQLEKMHLARELVSPDAFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4M6</accession>
    <name>A0A6A7C4M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_263062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4M6"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="394" mass="42114" checksum="A182B908A8B7C9A9" modified="2020-06-17" version="1">MGLHHQLNHGRVFHGAEARQHLRERKRDSHGTEIKMNIPKDHPAHQKAAAARPADPAQKAHYKQAAARPADRAQIDSILAKHNTPNKYQDGSRVADNAASSSISDAEASYRAAKSAAHAGPTLPPGHDNKNRFLNPPTSAALPTTSSGSNAIVGTPLSHSPQAVVGTPLSATRGPESNAGMTGGAMAGMALGIIFGFALVAGVLFFCWRRKRNPAGHREMADNKVNSIDSVGADMSEKDGGSKMVSSHAASTAPRLALRPNAQFLPNVNDKRSSAGSTDSKKPKSMWERRSTNDPFADGQNAEEIDEKASIKSAKPNNVHRVQLDFKPSMDDELELTSGQLVRILHEYDDGWALCIRMDRSQQGVAPRTCLSKQPVKSRDGSTGSNRSSAASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4U4</accession>
    <name>A0A6A7C4U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4U4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="19058" checksum="EF8FF40BC3F0D160" modified="2020-06-17" version="1">MAPSLLASYQPRCTINHSAMSTGDQTHCRPTEPTLDIPENTNAPESFKVNGLIERREDFSSNHAWGPCQPCNGECGSLETIDTHLHRLSFATPVRNEYAQNLRDIYKQAMEVRRREREKRKRKFDQLEEDHSSKRQEVGYSLVQDGGELLSYTVYYTEEGYSDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4W1</accession>
    <name>A0A6A7C4W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_256249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4W1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
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    <sequence length="1164" mass="128584" checksum="64439C35EE4A0AE1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A7C5H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Alfaro M."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
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        <source>
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</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50973" checksum="FC9A9FC7A9C663AB" modified="2020-06-17" version="1">MTTDYSTFKVTELRELLKERGIPQTGLTRKQQMIDALVQSDAKEDGPTSDAKQTEDKDKQEVVEDADDEKEPVNGDSVEANTAETRDAPEENVTDGVAAKAQDTPKATSEAPEVVSDTKKRKRRSPTPPLSDDAVSKKLKAAQEATVPAADAPVADAPIEDTNSPPSLHPPTRAIFIRELIRPIQPGLLREYLTKAAAPPGAQPNDKLVESFHLDLLRTHAFVIFTTVHAASRARARLHDTVWPDEPSRKPLWVDFAPESLVSEWIETELSDGTSRRDAKRYTVVYDTNNGSVTATLKEVQSGSAQAKRQPSNFEDHRPETTRRPSDFETDRADTRGMQRPASSRRDSDSFDILDQRFHFTTAKPKLYFQPQPPDIVEHRIQQLRHTVSRDWPQRRYDLSNYADGELRRYTFDDGYKFVDGGPDRGAFGNLFWGRRGRGGAPPFRGQRGRRRF</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="EMBL" id="KAF2862368.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Gonzalez J."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AFD_class_I"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="562"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1173" mass="129502" checksum="E58ACCF6F9F184B6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C755</accession>
    <name>A0A6A7C755_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:arachidonate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="29359" checksum="4CD82B0709425E69" modified="2020-06-17" version="1">MGINLLFYGAAFSGRPLEEAIGKVLAEHSQAEDPWRDYLVHPNSGMMFVCATLQDKGESMLLRSYAQPKDACPITDAAKAASESGAVSRIDIISAARATSAAPIYLPAETWQGIRFWDGGVLNNNPVDQLWNARYDLVAQGEPPPLVECMVSLGCGLSDMPQKKWWWWLRVAEVASRYVQTFLVNSIARHRDFARLVQRMRHRGDSYVNVRYFRLDCPTGPKFLDISDPSIMSDLEERTRDYVKGEAWDDIEAISQMLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A0</accession>
    <name>A0A6A7C7A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_192873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="426718at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="307" mass="36017" checksum="98E2C72DDCA58C99" modified="2020-06-17" version="1" fragment="single">TIALIIPRLSHESTSWVSELPSTIKPYIYTVDSPTSALHPPKNKGHEVSTYLTYIIDHYNTLHPLTIFMHSHRETWHNNILLPSAPELLSHLKPSHIQQQGYVNLRCDWDPGCPEWIRPGASLRDSRKTEEIILAESWAEIFPKDPIPKLLAQPCCSQFAVSREAVLRTGRERWVELREWVYRTEMEDALSGRVFEYLWQFIFLGRETLCPPAAECYCDAFGFCFEEGGLERWLELREQYGHFVTELKRWRDRAERIEEYLGRSGRLNGDEEIEIPEPGRDLFLQKRVDELGRELERLRKEALERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A4</accession>
    <name>A0A6A7C7A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_121712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7A4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="18943" checksum="387E324AFC282BFE" modified="2020-06-17" version="1">MRIDDNEELSKLSHPIHPPLILIDSHSIDGLLFIATGSAKRNNLRRDPPLHFLENMIPSPSRRQHSDYLTSIDPAPSSYNYPQLKPHPPRNQRPSDGGKPNTYSNGNDFTSHITGFDPEPRSPRIIFGMKPRTFCVVATVMCLVVVACAVGGAVGGRNLRFEGGSNRGSGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7E7</accession>
    <name>A0A6A7C7E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_211584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7E7"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="199"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="353" mass="41100" checksum="A89B8E5C697E0B6E" modified="2020-06-17" version="1">MDFASLMKEQIAAAAPSDKRKSTKRSELEAQREAEYRQEQEAKERARQDRLDKKRRAEGEEEAKQAERQAKRKRMAEESRRVAEEEAFEAENKRRKRIGLPELERKKEDSPLPEGEEDIADDELQDRLKALDEPRRLFGESHLQRLRRYRAVATPVPAKMTDGPIPTSLELVEEKDMKVPERVPIDPKDRFFLRRQIASYFDMLLLEWQLALARRPQDVKDSAPGKQAHGYFEQARDSLVPLFRKLEDDKLAEELFNAINEIVHLAQLRKYVSANDAYLRVSIGKAAWPIGVTMVGIHERSSREKLHERERNKAGTAHIMSDDTTRKMLQGIKRCLSFAQTRWPPDEAWQMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Q6</accession>
    <name>A0A6A7C7Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_280247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7Q6"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="101" mass="11399" checksum="3BA34F0858152E30" modified="2020-06-17" version="1">MEALIRSKVSNFLALMEALEIFNDSHRHAHHKEMQNVTSNETHFRVYITSDAFRGKPQPARHRMVYALLKDELAAAGGVHALQLRTRTVEEEERANASGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C827</accession>
    <name>A0A6A7C827_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_226160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
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</entry>
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                <person name="Lutzoni F."/>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9J0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="25071" checksum="A67366BFDEF7330E" modified="2020-06-17" version="1">MSSASSAAGPCLADEIGLHILQYLEGDAASLASVARVSREWNSPATEILWRHVDLKAFKGASRRNFSYFSGQLRTLAIHLDNTVQPDLSNLSFPRLEHVTIVFEDVPLGPMAPDVDTLMHIPNDVKHLTIEGECNNLALLSQMLDRLTQLQTINVEYLDCVGVSTWSLVMLLSSHSSLCNIYVDPQEHKRLLENFARHAPSRPPNTKALKARSMLNSKVTSLEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N5</accession>
    <name>A0A6A7C9N5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_209277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9N5"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="146" mass="15835" checksum="356D3D6C557ED1B8" modified="2020-06-17" version="1">MSRQITRTSTPVASSGSQTIVQAGPSTAPTATLRLRANAEPDDTPHVRWDDSVVDNEGMGKKSSKVCCIYHKPHEPGDSESETSSSDSDDSSEGEDLSRAQRAGNGGRKPKKNTKREDDKGKAKERRPSPNAYERQPKHSSNKQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9S5</accession>
    <name>A0A6A7C9S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_208677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9S5"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="28884" checksum="1D0B35A3EB960DBF" modified="2020-06-17" version="1">MRERKRKRGRGRDSIDKVDDGGEEVVGDASPGSSRSLPPSLALAYKNNWSWIATAPPPTRSESTAQFHFESHPEFTPNKSPKEILRQGSFGGSFFRPLTPRSLGGKVTISDDWMELPTSWTVGLDVERYLTSSVYDPSVNRYGVACGQSIEEWEAAGWINAEFDVRGWFQWYCRFFMGRRCEDDERQVGRWARCVGPRGRWRKALFKKYVEKGVRVITDEEGDGEDVSPVIHQTCLHWAFEPRQEDLDELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA94</accession>
    <name>A0A6A7CA94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_208465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA94"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="577" mass="64133" checksum="70B15A82C8B571C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAD8</accession>
    <name>A0A6A7CAD8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29121" checksum="98EF1C6785881034" modified="2020-06-17" version="1" fragment="single">MLGPLPTFESISLQRWENSGAELVASLKLATNLRELELDESPPFFCCNLDALLVHVPRLEKLRCAIHYDSPHPTLRQFAISPSLKALHLTIVNQLMFEIEPMFIASGQLLELESLIVHHDANTHGSWKHIDLEACISLKHVDLRNIIRDDTQLALSVTVTDLTIKYAMRTNFEGRVEHPSRDLHGLGIPYRLPYLQHLSLDFHPHGRFHIRQILQSGDGTCVFSLKSLSICTTTMNIDCILSHTHLQSINHLGLHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAI4</accession>
    <name>A0A6A7CAI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAI4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="407" mass="43940" checksum="1CE8260293810701" modified="2020-06-17" version="1">MGELADLEDMIGVLADPDDVSVEVNPEVPVAELYGDGLGDALPEPEPELVKDAALPVDAEYEDDECGTPVSVPDLDDVPAVPLETPGEDELADDPVNTEETVLRLNEELAGTPVLVLRLEVPTDADPDEVPAERDDEAEAVPLLVPYWLPLDDKLAGTPLLMLRLEVLVDAGPDEVPTGREDDSEAVSLLTDWLPLDEPDRSEAVELKLEDFEKTVSLLGPRLPLVVPTIGVELVLDDGADADVVAELKPLLLGALEVGVNKEVELNPDEPLNAEPVETLDPKLPVLELLDVPGEEVLELSDPEAELLLDVPAEYEETEPGLKDDTDAELLLDEAELNEPDVEPLLDVPSVYDELGPYEEVEAEPVLESDTLLLTLDVAGEYDDAELGLEEDAEALLERKLLDVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK2</accession>
    <name>A0A6A7CAK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_254917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAK2"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="67"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="352" mass="38596" checksum="5A002387A3FFD18E" modified="2020-06-17" version="1">MSDLFEPQEDALPPLVSPVGTPPRTPRGGTKASADGLQPSIAVPSPTSSEPRPSALDAPLPVVRCEVRARIPTKWRQDMWLHLYSNNVDNKEHLALVFGPYIWSKGLFEERPGETESDRLTRGAYHARLYPGRISSAGPEPKESPELANVPPLVRIHSECYTGETVQSIRCDCGEQLDEAARIMCLPATPTDINGGVIVYLRQEGRGIGLQEKLKAYNLQDLGHDTVEANLMLRHPGDARSYGLATAILQDLGLGGDRGIRLLTNNPDKIRAVEGPNREVHVAERVPMIPLAWQTGGRNGIQGPEYTSYLATKIKKCNHMLPDPMESKDLSDGDQSSRPLKKAKTSNNENPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAS8</accession>
    <name>A0A6A7CAS8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAS8"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38077" checksum="1844B30F025192F1" modified="2020-06-17" version="1">MTCAWSGSLLLLGGMSATLWILMRSLSTFLRVCFDKDMSRGWITALHVMAWGGAASFMGISLKFASPVYGLGPVCSPRGKPAFTTWFAWVLAFSGLAAILQFVTSVFCCGLFARHRFFANGVLPGPIGGPQPGGLSYGGEQMAATSDNSSGKRQSIFSGKAAQRLSAHMSSSTCSNSRWTYPRVRKQMMMQWRSVALSILVTVETVYFALVFVAITHQKRDAEETKEWIRCLIIAKGEKEKCRHLISGLGFGEKLIVSSFYMSAIIGVVTFMLMVRWDMFVGWWELLARRGKKREEDQFVILDSIPKRNAGGQVTTLQAFVSDDEDEDGKEWRRSSTLAGKSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAY0</accession>
    <name>A0A6A7CAY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAY0"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="316" mass="34816" checksum="23F76E22988B17AF" modified="2020-06-17" version="1">MSTTWSNIQSLVLLLGPILLPRLIAYTRTLTQQQPSTTRRKPPPQLPLALLTLTTLTSLILTLPIFTPTNIYMETSLPLTAPAERLQSRLRRSLTSPEQTYLSFLKEHGPPASKLYSLYGPAAFPSWTDPKDHLGNFIYALPGILTPHLLHLAIMGVVTGRQASRFRGRAVAACIALLGSELFYLHRGEGEFKFWKGRVVRLLGFAGVDVILGGMVLLAREGVSERVEGVRDGMEGLVKTLRGLGCVRNTVVRSSKLRGREGEFWETETDLMRGVFENEGVVVAQKGVLGRIDLEGVREEAGELVDSLLGRRDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDA4</accession>
    <name>A0A6A7CDA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_199820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CDA4"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="146" mass="17139" checksum="4B8B782B765B3A7C" modified="2020-06-17" version="1" fragment="single">KSYGLQWVENLFELRPRWTVNLDIVAIKSEAKKALYSECSQVSSYAQGSFHRHFENFSGNKTYLMRVSLPVDPYWKRGSEVATLTWVEKNTTMPAPHVVAYSSDRKNAVWFEWMLMTQLPGVNQSKKWRNISFELRYCITELVVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNR7</accession>
    <name>A0A6A7BNR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006073">
        <property type="protein sequence ID" value="KAF2857071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNR7"/>
    <dbReference type="OrthoDB" id="5947726at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="281" mass="32428" checksum="D0E7C035289EC377" modified="2020-06-17" version="1">MPKIQVTDEEIAALLRHDGFSIEEHTVGCMRREAGLFKRTSASDVPMLEDKIREVLVSEFDKGTVNSYGRNDLYDYVRWEHPQYHNTGRDRVYQIAREFNPDAVESRAKGVRGPNFVWSMDAHSKLEFWGVQVYAVIDEWSRCVMWTYVDITGRSAVSVLKQYVSTLAEGTRMPLWLRSDRGAETTLTADCHYDRSLKTHNKIPEELAFADCFRYGTSKANQRIESWWDQLSKSVLVDRGPYFENLAASGDYNNESDVDRIAFLAVYVPIMRIVVTDFDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP52</accession>
    <name>A0A6A7BP52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_279521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MU006066">
        <property type="protein sequence ID" value="KAF2857114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP52"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="52161" checksum="0189654F79AE8C7F" modified="2020-06-17" version="1">MAGKLWGGRFTGATDPIMTQYNESIHFDRAFYAQDIRGSIAYARANLKVGLLTQHEFTEIERGLNLVLKEWENRTFEIKEGVDEDIHTANERRLGELIGAEIAGKLHAGRSRNDQVVTDMRMWLRDQFLLLEKHLTTLLQTITSRSAAEISILMPGYTHLQRAQPIRWSHWLLMHGSFFLTDIQRLREVYTRVNRSPLGSGALAGNPFGISRESISADLGFGSVLPNSLAAVSDRDFVLETLQWGSLLMSHISRFAEDLIIYSSAEFGFIKLADAYSTGSSLMPQKKNPDSLELLRGKSGRAFGQLAGLIMSIKGIPSTYNKDLQESVEPLLDHVKTVSDSLQIATGVLATLSVDAARMHAALSPEMLATDLAEYLVHKGVPFRETHHVAGRVVALAEKRGVAMDKLGVEELRDVDPRFEDDVLRVFDYEASVERRDVTGGTSREAVKKQIERLKREVREGGLSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPE8</accession>
    <name>A0A6A7BPE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006060">
        <property type="protein sequence ID" value="KAF2857184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPE8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="18862" checksum="AC6804E5383E39A5" modified="2020-06-17" version="1">MRIQQAIAIAKADENRLIRFISRRDRFLDALDWDALPEQMAREAAMMDELLATELAEAACYVIWLEECLSYGVEDVIGAHHLQPVSVIRAVASFLIRRPVSALAVVFYLAAMICAQNMWLLGSDPEPATVTSDALVNMVLSVSHATATWGFIGGFLVVGFLIQLLALRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQA8</accession>
    <name>A0A6A7BQA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-related protein, ARP1 class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_223284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQA8"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="Actin/actin-like_CS"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Actin"/>
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    </dbReference>
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        <property type="entry name" value="ACTIN"/>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="42406" checksum="02ECBC2DA19C341D" modified="2020-06-17" version="1">MADLHNTPVVIDNGSGTIRAGYAGEDLPKCFFPSFVGRPKHLRVLAGGLEGDVFIGSRAQELRGLLKIRYPLEHGVVTDWDDMERIWQHIYTDELKTLSEEHPVLLTEPPLNPRSNRDTAAQILFETFNVPALYTSIQAVLSLYASGRTTGIVLDAGDGVSHAVPVYEGFAIPNSIRRIDVAGRDVTEYLQTLLRKQGSVFHTSAEKEVVKAIKEKTSYIALDPKKEEKEWLTTSSRGGEGKSVSYTLPDGQKLKIGAERFRAPEILFDPEIIGQEWSGLHQMVVDAIGRTDMDLRKSLYANIVLSGGSTMTKGFGDRLLHEVQRLAVRDMRIKIFAPPERLYSTWIGGSILAGLSTFRKMYVSIDDWHENPDVIHQKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQB4</accession>
    <name>A0A6A7BQB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQB4"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="209" mass="23760" checksum="B31C681E73E000A0" modified="2020-06-17" version="1">MVTVFDDPANFNVKHQLQHTWTLWFTKPPQAGKSEWGDLLKEVISFDSVEEFWGVWNNITLASDLAQKSDYHLFKKGVRPEWEDPQNKNGGRWSYTFRTCKPSDDIWLNVVLAAIGEQLEDEHDNEVMGVVINIRKAFWRVGLWTRTNGSRKKGKEGDTSGEDGEARLKKIGKRFKDALQLPPGEGIEFSSHSDAAHSGSTRAKTKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQT0</accession>
    <name>A0A6A7BQT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tricorn protease domain 2-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_179526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006055">
        <property type="protein sequence ID" value="KAF2857247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="5">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="340"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="901"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857247.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="22054" checksum="1EA728C78EBC98DB" modified="2020-06-17" version="1">MDSSRPQLITNQLSLALPPNLQPCATRPQEAKASSFQENSLQAHLPRDPPPHSRAEQDLALVRVLEEQIGPPPTEPQTEKQRARRTRALDAAFKCIGKDSFTMAWLTRHPADTNLPFERRPFRTQLYDYQADVEDTGEDFIQDAQRDLFGEVWMSSTIPQGTWWKGERRLSSSSLSEPPTLGVSKNEDSSHDSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSN3</accession>
    <name>A0A6A7BSN3_9PEZI</name>
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            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
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        <name evidence="21" type="ORF">K470DRAFT_222298</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
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    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSN3"/>
    <dbReference type="OrthoDB" id="844at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:1902975">
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MCM_OB"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="468"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2857947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="821" mass="92177" checksum="A456559948FEC1F9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BST9</accession>
    <name>A0A6A7BST9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_272722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BST9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="218" mass="23061" checksum="B73486658A3EFF01" modified="2020-06-17" version="1">MGLFKLLSKLPAKAKAASKFRHLGRLLKGGGAREVACPAVMNSPQLSLSSYVDTELDGGVPLLFFAADSTFNTQGGNISSDDSSDGGVYISSPPASIVNLPVISNGGNSVRSSSKGEPLSGQELDKALMSSPGGPWDAYAACQHEGVPSSVLASITTAGAQERCYRLEGRLRPLFCEVKQVYLARMATGRAFSTPGTDLRRVVNMFGPEAHLQRDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT29</accession>
    <name>A0A6A7BT29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_131661</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT29"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000014">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="74"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="214"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="481"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="580"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="709"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2858486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1160" mass="130154" checksum="0CACE19A924885C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTM1</accession>
    <name>A0A6A7BTM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_133386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858432.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="37290" checksum="A9F138B7D9D9C364" modified="2020-06-17" version="1">MTTTLPSPPTDVISSLHFCPSGSLLAVGSWDCKIHTYILTDGSWTPSAAHPTRAPILDLCFGDSDNLIYFVGLDRDVRSLNLDNDEQSVLSTHEKASNKIAYSAAHGLLISTAWDGTMHIHDLETGQVAKVALTTKPFGLALTEDKCVVAMAERKVSIYTIQSLRDAVDGRTADPQPWQRRESSLKFMTRAIAAMPNGTGFVTSSIEGRVAVDWFDEGHQSDAYAFKCHRQTESLPSSNGVDTEEVDLVYPVNAIVFHPSLGTFATGGGDGVVASWDANTKRRIKNYSRLAAGVTSMCFTPDGTVMAVGISPTGEDGMESESVNPDKVQIVMRTLGPNDFKGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTM6</accession>
    <name>A0A6A7BTM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_152433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTM6"/>
    <dbReference type="OrthoDB" id="3713149at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="67" mass="8130" checksum="210ADD2964FF9414" modified="2020-06-17" version="1">MFCETIQPSWTNFKPRLFAVYFVGVTARNVYDIWLPQSDSVVRVRYVVLEESHFFNPERRSNRRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTQ7</accession>
    <name>A0A6A7BTQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_193012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTQ7"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10766" checksum="354A5C15CC692D30" modified="2020-06-17" version="1" fragment="single">MFFLFTCGQHSFNKPLKGGEGITVQCPNCHNHSAKLESRWEWFTVCFVPLVPFSLKPWHEVHCNICQYRQDIKYRPDVQQMLNGGQPMPMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTW7</accession>
    <name>A0A6A7BTW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004222">
        <property type="entry name" value="Os02g0288700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
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    <sequence length="1518" mass="169148" checksum="C9933A9F912FD43D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="223" mass="25774" checksum="BDB8B1F0E47F491E" modified="2020-06-17" version="1" fragment="single">MESYHGWIRTPNDAILLFEACRIGLLPRVQRRLSEKERRAIRPGSVFVWDEQEAGMRRWTDGKSWSASRVSGSFLTYREMLGKREVQNMESDRQGGKEIDLADDGFHYKSDGLIKQSFSITTSENQHLHLISYVSRNPTHMSDLKQPSQDPRFRHIRPDRGRYPESTVQEPQTIPAVTRGPLMSSAPRPALHRSPSSTYHHSMPQYGPYFDHSHHYPGPRHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BUD6_9PEZI</name>
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        <submittedName>
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        <lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="cullin-3 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
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        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
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        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
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            <end position="685"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="816" mass="93897" checksum="33A607FF76D0CB1B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUV3</accession>
    <name>A0A6A7BUV3_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="8346" checksum="9AA71BDEE415E748" modified="2020-06-17" version="1" fragment="single">GGYVYDCNAKLPDLAVSIGDYMAVIPGSAITYAQQGDKCFGGVQGNKGQDVQIWGDVFLKPFLAVFDGGNKQFGVAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUV5</accession>
    <name>A0A6A7BUV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8017587at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:2-methylcitrate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="407"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="470" mass="51987" checksum="A76495C135B3D74A" modified="2020-06-17" version="1">MSASTVSRTTIRRSLASTAFSSRNVAFRSYATAKNATLKETFAASLPEKIEQIKKLRKGYGDKVVSEVKLDQVYGGARSIKSLVWEGSVLDSEEGIRFRGRTIPECQKVLPKAAGGEQPLPEGIFWLLLTGEVPTEEQVRQLSAEWAARSEVPSFVTELIDRCPSDLHPMAQFSLAITALEHESSFAKAYEKGMPKTQYWEHTFEDSMDLIARLPTIAARIYRNVYKDGKVPAVQADKDFGYNLANMLGFAENTDFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPMLSLAAGLNGLAGPLHGLANQEVLRWLQEMKKSIGNDLSDENIKKYLWDTLKSGRVVPGYGHAVLRKTDPRYTSQREFALKHLPDDPMFKLVSQVFKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEQNFYTVLFGVSRALGVLPQLIIDRAVGAPIERPKSLSTEAYAKLVGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF5</accession>
    <name>A0A6A7BVF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_277896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVF5"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="277" mass="30388" checksum="C0322EFEE67F9762" modified="2020-06-17" version="1">MSYTHFNLTTPTEWVAHVEINRAGKLNSFHEEMWHELGEIFTKLSHDPNVRCVIFSGAGDRGFTSGLDVQAASKGPLMSSEGSDTDPARRATFLRRHISDFQACINTLETCEKPVICVLHGIAFGLALDLASACDIRICTKNVRCAVREVDIGLAADIGSLTRLPKANLPFSWIKDVCLTAREFGADEALRVGFVSEVAEDKNKAMQRAVELAGTIAGKSPVAVQATKEVLNWSRDHSVQDGLRYVQVWNSAMLQAGDVKSALMGGIQKKKPRFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVH3</accession>
    <name>A0A6A7BVH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_282798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVH3"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="557" mass="59722" checksum="B1458A61C2E89AD7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVK8</accession>
    <name>A0A6A7BVK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVK8"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35791" checksum="05D22C5150E408E2" modified="2020-06-17" version="1">MLPTKRSEKKPQTRRFPKPGIVQILTFLSILITAVAWILSLLCMYAGHRPGVLEKYAIFTLNTTRIGEPLLDTIDGEVQNLTTKVNDFLAKRDLKQSRAFPTIIPDAVSSHAAQLTAAAASHISAASSEVQSAKSAGASVVASAGSTMESKVMEVIDDAYRGAVQQLHLQGFYSIYPMATCEGRYQYPNGTNVTASDDPMVPSKRHTSKCSRHSDINLVEVSKILYVMAIALVGMALLLAIVGLVTFRSHWPAMANVVTNALALIILALASTATHGVAVGAEHLVNKFGKEFGISAKAGGSFIALTWTDTILVFVNLVMWVVIFLFSLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW34</accession>
    <name>A0A6A7BW34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_218969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW34"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="311" mass="33247" checksum="8987DE54BF26D03A" modified="2020-06-17" version="1">MHAGRGKKLTTVCSYESLPPNFSLAANMAAGAFAGIAEHAVMYPVDVLKTRMQVVSPSPGAVYTGIGNAISTISRLEGYMSLWRGLSSVVVGAGPAHAVYFATYEVVKQSLGGNAQGHHPFAAAMSGACATIASDAFMNPFDVIKQRMQVHGSTYRSIAQCARSVFHNEGLRAFYISYPTTLTMTVPYTALQFMAYESLTTAIQKRRRNNGYDPLTHCVAGGVAGGVAAAATTPLDVVKTLLQTRGASSDAQVRLATGLWSGTRVIWDREGARGFVRGIKARVLMAAPSTAICWSAYEVAKAYFINKREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW56</accession>
    <name>A0A6A7BW56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW56"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="60" mass="5985" checksum="864372DCCD07F03A" modified="2020-06-17" version="1">MNAGVPSQSSPSTMPSICSCGPTCCVRGSCADLSPSSPVVNGLHGTGSSLMKRTHDDMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWE2</accession>
    <name>A0A6A7BWE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="13" type="ORF">K470DRAFT_277777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWE2"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="18525" checksum="776DEB08F268447F" modified="2020-06-17" version="1">MDRPLQDVPHAQPAPVLQGQTLIGAPSVPQLPPQMFTTASQLLDLTDKKLVVVLRDGRKLIGALRSWDQFGNLLLDDTIERIFAQNLYADIQRGLYLIRGENVSILGEIDLDKDDYIPPPFQRAPYETVESMKKAEDSERKRINQIKQKKLAATGFEGDVGGEATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWS0</accession>
    <name>A0A6A7BWS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_90235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="267" mass="29084" checksum="7607D7F3910AE51D" modified="2020-06-17" version="1">MMANANGQRQSVRDLQTTATTRRAGKASPVTTALRSRDPVSAIARKYNTSNAVSAQATTTQPYRQKRLSDLTTLYQSGRDVVKREISSRDVLAGVDGNLLSTLRDRCSTFLFVQSLIILCEATLLSISLLSRTLAVNTGDPLGHSFELPAPIHGLDLHLLFSLHFWVPFLIWAATSVLLPAAAGSIFNFTRRRTQVDPVGFNLVKAILAIFMLGQGLAGPGRVARLQIEKAFPGGWRFILTDCLVAGIVAFWDGVQLQGQVINHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWS8</accession>
    <name>A0A6A7BWS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_265525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWS8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15203" checksum="9DC2E4422BD3E088" modified="2020-06-17" version="1">MWQKNNTITLKYTTQMRKGMGYSQNFYKDPKNHPAPTTRRKINITPLSSLVSKRMGTPRKNRFYEPPLQTASTNRPAPKTPMQATPQHQIPHHQEGDTCLAPRQSPLLAPETPALSRTTSARVQNVEYVPLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWX4</accession>
    <name>A0A6A7BWX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">K470DRAFT_277914</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXA0"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="25716" checksum="50880FA2CC5620A2" modified="2020-06-17" version="1">MPQNELYQFSLLNALMDGVASHGLPCRTLSHHGTIGLGTFHKMDGEMIMLNSKTYQLKSGGDVRLADPDTPIPFAVVTNFSPEKKVDDLSLKVKGDLEKVLGDLCPGTKNLYLAFTVRGVFGRVKARTVKGQEYPGERLSELGKKQSVEVYEDVKGTVVGFRTPENWQGFGVAGLHLHFVDDERAKGGHVLELEGKYLGLEVAVISRVVMDLPRTEEFNAASLVTDREGVKGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXA7</accession>
    <name>A0A6A7BXA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_218423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXA7"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="46618" checksum="29701B6B764AD3AE" modified="2020-06-17" version="1">MGLSSPPSSPLSSIPSSPLSSLACTPEPPADFKLPLSPPSTRSPKKPNYPTPPSSQSTSNNCSPTPDGSPSNAQRPEKRREMSSPPADAPPKKRRTVSRDRPPRTTEYLDLRRKEIEPCQQEQLDRLMEVLNKRQKIVVIAGAGISVSAGIPDFRSSTGLFQRLKEEHNLKGSGKDLFDASVYKDSDSIRTFHSMVTSLYKSTKKAKATPFHRMLARIADEGRLMRLYSQNVDGLDTGLKPLRSRIPFRKGDDGKWPLTVQLHGSLEKMVCTKCHQLSNFDPQTFQQAGPLPPPCPSCLEFDEIRTVQAGKRSHGIGCLRPRMVLYNEMHPDSEAIGSCTKHDLRKRPDAVLVVGTSVKVPGVQRIVREMCATVRDRKDKSLAVWINPTPPPSTKGFDKCFDMIVQSNCDEVARRAAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXQ7</accession>
    <name>A0A6A7BXQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_277295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXQ7"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24393" checksum="B9EC4F5080161350" modified="2020-06-17" version="1">MSILQVFLTLSRPKHPPINLTPLRSLSTKPSPITNESIPSRLIALINPSGKLTGVFHKSTILSQLTSEEILIQKGSGPVPVPKGEENRDGGGNEDGSGEKITLPICKIVKKKELYLRDKEKKKKKEGKERAKTIELNWAIDGNDLAHRLGKLKEFLEEGRRVEVLLAVKRKGGRRASTEECKRLLEKIRGTVGEVEGAGEMKPMEGKVGGFVTMTLQGQVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYC8</accession>
    <name>A0A6A7BYC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_217664</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYC8"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2860214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="263" mass="29414" checksum="5C7BBC27DCC8EA04" modified="2020-06-17" version="1">MTDENIFLFWPNLIGYARIILAIASLNFMPLHPRRCSFLYTVSCLLDALDGMAARHFEQSTRFGTVLDMVTDRCTTTCLLVFLAAGKPAYAIYFQGLICLDVASHWILMFATLAMGGQGQSHKNVASRASWIMKVYYSNKTVLFIVCALNELFFISLYLLCFSSPLITPALLPSAGLASDGTTPATPHQPEPSLFFPSPFSAAAMEMARANKMDSTVPWILTLASSPVMLLKQYINVEQLVRASMWLAEGDRRDRMLRQMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE2</accession>
    <name>A0A6A7BYE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_80200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="101" mass="11161" checksum="AB4900250538858B" modified="2020-06-17" version="1">MVQPSPGATTYSEHLTRRGDEVFWKAGRKAMRHILFWEPFGAELWGDNHALTTCAISQLETSAYGVLGKQNCQPAVRGEAPPPPPPPPPPRIHRAQLHDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYF9</accession>
    <name>A0A6A7BYF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_218099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR38790:SF9">
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    </dbReference>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
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        </source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="351" mass="40201" checksum="A357F3AFD122CA9D" modified="2020-06-17" version="1" fragment="single">EAGNSQDPRKWAYITIEDFRATSNWTVLGYIWLWIMALAAVAVYALDTFTAVNLLVLDQWSSQVKPAIPMKYTKWIFAACILFSWALCAYEWIRAIRVIRRGGVADSYMDYVARNLQCIRPGGWRRFLVFAELTKSKKGVDYIAFFVYFAFTGAIRIILAEGPRQFVNAITLYSVMVAKIEVHGKAVGRSQFDQFFFNLQQLAHSNPEEMLILCSMLFTLVIWMFSMLCLIAAVILYLVFLWHYIPHSDARLKVYCRRKVDKRLERIVQVKIKTAVEEDERKAERLASKRGHPPTLKRQPTLPEVGKSPDLPTWDSSGVPPLLRSNTSTTVSTLPLYPGRSGSQRTLPEMP</sequence>
</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
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            <dbReference type="EMBL" id="KAF2860195.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="567" mass="62101" checksum="79323C51A50BD5DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C046</accession>
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        </submittedName>
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    </gene>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="228" mass="24816" checksum="524518010FD474CE" modified="2020-06-17" version="1">MNPTIDSGICMVSQATPSHTNKPSFCAGNYPTCPVPDISNYTDHVSSTCRKAAYVSGYPQSINPCLDFEAGHEAERGYDNSHWVCPFQGIIQDPSANHPPHHKGIMLNDDPDATDDESWLLSLRQHVERLGDQSHKTTSPISGNRGLTSRVPNSATGAPRKVSKRTQRPSGPNIATFSFNPSRAAVVPVPDRSNPAAAELYIPTDPTVQQQDFWQQSAACTDSGFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C069</accession>
    <name>A0A6A7C069_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_270853</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2860325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2860325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="115" mass="13382" checksum="232E48083E7FE595" modified="2020-06-17" version="1">MPTFPTRPFRGASYTSSIAGKYRNSLNRHPFLLFGLPFVLTIVASSFFLTPATAIRYERHDQRVRRVSEEEKLGLGKDRRKVDVREEYFKLAAKDLENWEQKRVKRLPGEPDGIL</sequence>
</entry>
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    <accession>A0A6A7C088</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00505">
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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    <sequence length="570" mass="61977" checksum="C567C08E4597872D" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR36168">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
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    </feature>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57075" checksum="0FB5805C07673985" modified="2020-06-17" version="1">MPTPPDEPEGPSSSSPKPSNINWRETAFKMSEAALTTLASVLVLGLFGYSYNLYYKAQVLSKIENAFAPGDPLLDLAGSSPPDDPKEGWVPRAEQTLIDNIIGGKLTGQYHLLVGEKGTGKSSMLIDAMGKIDGEGCSVLECHSDPEIFRIRLGKALDFEFHEDNIGALFSIRGPREGNALLDVERAFNKLEKIALRRRKKLGRPLILIINSIHLLRDDDNGRDLLELLQQRAEAWAAGGLATIVFNSDDYWVYERLKRHATRMNVIPIFDLEKDKAIAALRDYRLRYKSEEPDGKLLEEVYNLVGGRLTFLNRVARSDDMVATCEAIYEAEKTWFLNNCWILGSEMDDDVMDQQKYASAAMVLAKALVDCEKENMGGKCYDEEKGWILPEIPLHKAREIMTRADFIQSYDSINLFAIDSHAMVRADSVPMMRAFREICGQEGFEEYLNATLQRIGDIESLGRTRELTIKDLWDNGRYNVRFDEEGKRVTFEVGEKKEEEEGDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3916525at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="37895" checksum="AF9A5F1378089B8D" modified="2020-06-17" version="1">MRKPVVDGPFLLKSVRCDNVTSIMDPDKRTNTKYLRLCVEQHECTLEMWHASPWVHEVNRDLYSYAANAEVVYGRGRGRVVELFIMNDGKETPALRRQLVSHGFEVLPPLLVDPAYAGYRDYCKQHINDQVANQAKVYQSPMPAVLLADTLEYGTIVDSDCPPRALRAVVVEMSEFKQVTMAMWAQKTTSDEEPVPMEAWPTITANGVSYPVIGFHRNGTTGFLCGDEDLPAWFGGQTFEILWNNRLHDREITDNGLGNGEVATGNENGNGNPAGGNEVRNDKPAADDEQEHSTPATNNEDGDSKRVKEVGSGDGSTKSEEPVPKNATRMAEQRGCNPIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C180</accession>
    <name>A0A6A7C180_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_294527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C180"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="30757" checksum="FDFF045F693D6F99" modified="2020-06-17" version="1">MQSVSAVENHDGHHSNPRRKNSSSRTYVVRDNSYNRRSTRGSDGTASTTASSGARTHITAPPEYSKKFVVVGDGGCGKTCLLISYSQGYFPERYVPTVFENYITNVEHKPSGKGVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPNSLDNVLDKWYPEVLHFCPTTPIILCGLKSDLRHKRTCIELLKAQGLTPITQQQGRSVADKMGAMYMECSSKEMNGVHEIFDTAIDIAVRGPEQIADDKHRRTASAGGAQTGGFAAKKKKRSNCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1K3</accession>
    <name>A0A6A7C1K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lem3/Cdc50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_230945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1K3"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="417" mass="46834" checksum="BB067473623BD4DB" modified="2020-06-17" version="1">MAQGDEDKDDKKQKSRRPPNTAFRQQRLKAWQPILTPKTVLPLLFTVGIIFAPIGGLLLWTSAKVQEILIDYSQCISKAPACQSGTTPPSTAYVPSEYVRSMFKNKTDPADAPTWCRTTTMDAQTFGGRRRLRSNVCHIQFQIPDNLDPPVFLFYRLTKFYQNHRRYVKSFDQDQLAGQARSGSDINGSDCSPLQGERGADNKWRPYYPCGLIANSRFNDTFTLPRLLNAVASSATNITYNMTSKGTAWASDAKLYKTPPGYSDYSEVLPPPNWRKVYPVYDSSTGWPDLHGDDHFQTWMRTAGLPTFSKLYFRNDNETMQAGRYQVDVYDYFPVTNYDGTKSIYFSTRTVMGGKNPFLGIAYVVVGGLCILLGTLFTITQLIKPRKLGDHAYLSWNTDQPSTATASGRAPRAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1M4</accession>
    <name>A0A6A7C1M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_286316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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            <begin position="74"/>
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    </feature>
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            <begin position="85"/>
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        </location>
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    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="371" mass="41186" checksum="703D558FAB1E97D4" modified="2020-06-17" version="1" fragment="single">MTKASVEANTSLFLRLPNKLLKLIDLVPDTVIDLGKPGTVPSNALVGRCYHRTYEVLDASPYLQPISPSLLNAETVESSPDDLPKTNQNTIDSSTRQNLTQSEIESLKRGPITGTALITKLVENHTALAEKTSYSKAKYLLRKRTKYLKRITLLPMSIPNLTTHLLDKDPSRIMHIRPETLSLLLSHANIHYSSAKRYLVIDETGGLVVAAMAERMGLLSTHYRDLPTSHGRDSPPSRYRDFPLPARGNSITLLHTSIQPNISLLKHFGYDSNSPDSTHALHTHLKPLSWLQLLHPGEDGMYTEPPGVGAEELGGYKPAKRASYFRKRRRWERCRSIVDETRRGGFDGLVVVSCLEPVGALGHLLPLVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T0</accession>
    <name>A0A6A7C1T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_256855</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="106" mass="11675" checksum="25C5D0B332501292" modified="2020-06-17" version="1">MDFKQGAKRDPELFVLFGIMAGAAGLVGWHFSRNPTSASSESPVAKAPDSEPWKTGGDARYQYHPGGDERRGRRDAPSALSEVTIPNVNLPKSLHEKYNKWGKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C217</accession>
    <name>A0A6A7C217_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_256887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
    </feature>
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            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="16673" checksum="54147FB58C17D8F2" modified="2020-06-17" version="1">MNTTAQMRECADDLRDKIDALEAAFAPILKAGISGSASKLPLMDQAQLYTLTTYAIESLLFSAIRLDGSEDAKKHPVFQELNRVKGYFAKIKAAQTTAEGKRSRVDVEAVDRMIKHGTESVKKLQHGPPMRERKRKRAEGKDEVNKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C286</accession>
    <name>A0A6A7C286_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_270003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C286"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="20529" checksum="00A008B97A00BF34" modified="2020-06-17" version="1">MKAVIQRVKSASVTVDGHLVSQIARGVLVFAAIGRDDTKHDAESLATKLVKVKLWEDDNGGKWKRSVRDIDGEVLCVSQFTLLATTKKGNKPDFHRSAAPDRARELYDTFVAKVRSEYVAERVKDGVFQAVMDVALVNDGPVGVDYRSDDSAVTIEIETNPPPLNVPEPVVQGQRETFEYPESLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2B2</accession>
    <name>A0A6A7C2B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_285955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2B2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="230" mass="26335" checksum="00959CC1FFEEA9AB" modified="2020-06-17" version="1">MPSFCPIGLQGRSNKLFGPKHAVKHIVSAKHDREKRDLRIGSEKWQEKERWEEANRSKARQNASKAALRISRQQAREMAALRDARAANSVPSFAIEDGHTEGDFLEFGMLDITNALVENCHSKDNLPSFSICSMLRSHAYKILKIYQKKWIFRMTTVSSKARFTAAKTRNILQTTLTDRLITMAILCMGRTKWRRLNLDLVGRNLCHSQSLSLCHSRDLHSKNFLIHGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3M6</accession>
    <name>A0A6A7C3M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3M6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="501" mass="57571" checksum="195126D008C1C2BF" modified="2020-06-17" version="1">MNDFVLRLPIFLLIAFICYQTYNYITLSAKRRAFQRSQGTLPAPWLPGTVDKLIGWNHFRDDAQALQEQRFLSRQQSLYEDNNLRTFQLINSGRHMHLTIEPENLKHVLAIDFKKWGLPKSRMDSFRPFLGDGIFTTNGTAWSHSREMLRPNFVRAQIGDLSMFEVHITHLITSLPTDGSTVDLSERFFRLTMDSATEFLFGESTNSLLTQNHESFSTSFNRGQDHIARSARFGIFAKLAQDNTTWPHDRKFVHDFVDYYVSKGLSKKCSPSERYVFLDELCERTSDPIHIRSELLNILLAGRDTTASLLTNVWHVLSQNQDIFSRLKSEVDALGGAMPSFEQLKQMKYLKAILHECLRLYPVVPGNSREALEDAVLPLGGGEDGKSPIFVPKGEMLGWSVYTMHRRKDLFGEDAEVFRPERWLDEDNKRGLRTGWEFLPFNGGPRICLGQQFALTEASYATVRLCQTFDRVECRDPTPWTENLSLTCRNFNGAKVGLFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3N8</accession>
    <name>A0A6A7C3N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_213729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3N8"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="41038" checksum="5AA571B4CE9A21A4" modified="2020-06-17" version="1" fragment="single">VIVAETISLGILSLPMALSTMGIIPGVILLVIFSAMSIYTGFAMTSFKIAHPQVTTFADALELICGRRVGRLLGSSMQALLLILIAAAHIVTFGGELNILTDHATCMMVFTVAGAAISWAMSVPSRTFDKAKYVAVASCISIACATAVAMGSIIHSHSSPFTAGITHPKPASSFAKGAVATSNMVLAYNGQMAYFSIMDEMEKPEDFRKSVALLGVVSTAVYVASAVVLYWFIGVDVKSPALENAQPVLRKVAYGLATPTILVAGVIPGLVAAKMICEAQGSGESTLTPPPWLVWVIVVTGIYILAWVLASVVPVFSQLLGLIGAALGTWFSLGIGGIFWLHLNWKAERDVKYWFGVAWALFVIGVCAVTCVLGVWGTAVGLQGGRVFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Q8</accession>
    <name>A0A6A7C3Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_213452</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Q8"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="31885" checksum="00698C0D90259130" modified="2020-06-17" version="1">MALPGNPAHLLPPSWAKVVQAWLEEDTPSFDYGGFVVGEGPAEAHLLAKSRGILAGVPFVDEVFKQLGCKVEWFAQEGNEVGRIRKQHIATVTGPTRHLLLGERVALNVLARCSGIATRSRSFLIMLRNADYKNRLAGTRKTTPGFRLVEKYGMIVGGCDPHREDLSAMTMLKDNHIWACGGNIRTAVAAAKSVGGFAIKVEVECQSEEEANAAIEAGADVVMLDNFSAENVRAASKSLKDRWGRGKFLIEVSGGLTEDLVGEYVCDDIDVISTSAIHQGTKHVDFSLKIVPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3S8</accession>
    <name>A0A6A7C3S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Distribution and morphology protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_213333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3S8"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="9028" checksum="725D13A0BA0DF573" modified="2020-06-17" version="1">MSSSLAPECNDVKDRYDACFLKWYSEKYLKGAASADECEGLFNEYKTCLNKALKDRGIDKMLEDARADAKANDEEFMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3T0</accession>
    <name>A0A6A7C3T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_214472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3T0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="469" mass="50856" checksum="2E1B7FE89F0A1A4A" modified="2020-06-17" version="1">MGEQGKITTISPVTNKGIYERQEPSDEALKHIPKTAQAAFLSFRQTSLADRQKIVKKALELITSRKDELAKELTEQMGRPISAAAAEITTAVARGEYMLKISDECLRDTPGEAQKGFKRYVRKVPLGPVLVLFAWNYPYLILVNSLIPALLSGNSVILKPSPQTPTVVERIHGIFNEAGLPKNVIQYFHCGNFGKIEKLIQSAEIQLVCFTGSVAGGLAVQEAAAGRVDCRVGLELGGKDPAYVRSDVDVAWAADQIVDGAVFNSGQSCCSVERVYVAKEIHDDFVKAVQKVLEGYALGDPNEKSTNVGPVVSKAAAERIAEQVAAAKTKGAKDVTPANKTFTSPPSGGNYVAPTVLTNVTHDMSVMRDETFGPVIPIMAVSGDDEAERLMNDSSFGLTASIWTKDTECGERLADRIEAGTVFVNRCDFPSPDLAWVGWKDSGKGQTLSSFGYEQFSRLKSYHVKFLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y0</accession>
    <name>A0A6A7C3Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_256185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Y0"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="431" mass="47968" checksum="7AB95C1C27EA1E1D" modified="2020-06-17" version="1">MPDPSSLYISADYRPRESLAVRASADGIPATPTGPRADQSTFASTLGGNKPPAYISNDVDTTITARFARVSLTGNGEFSQVYRVQDPLVSGIALPSRGNPAARIWAVKKSRKQYLGNRDRMRKLKEVSILRALRGNEHILEFIESWEAESHLYIMTEYCENGNLKDFLLQAGFKSRLDDFRIWKILLELAQGVKAIHDANYMHLDLKPANVFIDWEGVLKIGDFGMASEWPAPADFEGEGDREYIGPEVLYGKVEKASDVFALGMIVLETAGNIVLPDNGLSWQRLRAGDLSDLPSLTWTSESSLNRDEHGNPLDTPESSREAFSSYPDERSDDLGFLRPVEAGKCRNTCRDLVTPPNFMVDQTDPDSLENVVQWMIKPDPARRPTVDQLLMTGGVQWVDKRRRSGATIYEGSWGPADAVVTPQDVEMVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C413</accession>
    <name>A0A6A7C413_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_256513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C413"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="146"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="503" mass="56888" checksum="80B320B09F19DB00" modified="2020-06-17" version="1">MLDINDFLAERGGDVEAIKDSQKRRGAPVEAVDDVIASFRDWMSDNHNATTLLKEKINKVQVDLKANKKNKGSPEDFQKLLTQKQELEKEQKEAAEQARAKLPVYLRKLKAIGNYVHPSVPVSNDEANNALIRSWSPEGVTPSKKDCLSHHEVLTRLDGYDPVRGTKIVGHRGYFLTGNGVWLNQALIMYGLDFLASKGYTAVQTPYFMLREAMAKTAQLEQFDEELYKVTERENDPVSDKYLIATSEQPISAMHEGEWLHKKDLPLKYAGYSTNFRKEAGSHGKDAWGIFRVHQFEKIEQFRFCAPDESWKHFDEMIATSEEFYQSLGLPYRVVAIVSGALNNAAAKKFDLEAWFPFQGEYKELVSCSNCTDYQTRELEVRYGQKEGGKPTATGEDGQQQKTNRKEYVHALNSTLCATERALCCIMENYQTENGLKVPEVLRKWIPGQPDILKYKKELPKDSTSLKAKGKVDGAKGPKLPKEGDMVERPKHPKGVLGNASWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4J0</accession>
    <name>A0A6A7C4J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_228099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4J0"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="793" mass="90700" checksum="A4D74994861043DD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4K5</accession>
    <name>A0A6A7C4K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_280941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4K5"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000094">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="68"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="476" mass="52474" checksum="8761970DF8EE88EB" modified="2020-06-17" version="1">MTATNGTSSHKYRRISPQEQTENPFVKLIPDQQIAIIPEFELESGYTLRNVPLAYKTYGTLSPGGDNAMVICHALTGSADVGDWWGPLLGGPGNDEEEAKAFDMSRFFVVCINSLGSPYGSASPVTAVDGNPSNGIYGPEFPLTTVRDDVKIFKLLLDDLGVKQVAAVIGGSMGGMLVLEFAYSGPEYVRTIVPIATSARYSAWGISWGEAQRQNIYTDPDYQDGYYDLERPPKSGLAAARMSALLTYRSRNSFETRFGRNSPNPVRQQTINGYSPFAIHNEGHRKAGSPRPRPSIIDAQFSSTATPLPTPPPSAKRISTYYSANSYMRYQGEKFTKRFDANCYIAITRKLDTHDVARGRTSSPNPTQDEINAVLGTIQQPTLVLGIQSDGLFTYDEQQQLSAAIPRGELQTIHSPEGHDAFLLEFKQVNKLILDFLRRELPDLMKREPVLQAIEPTHEAKTSTFGEAEVGEITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T4</accession>
    <name>A0A6A7C4T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4T4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="26500" checksum="EF1CFEBC628AC699" modified="2020-06-17" version="1">MDATFYPGGTRSLTSIAVQSFCLGLCFGISLTTVVFHTQIWRLPTFLSLLCVFHFLEFFNTARYNTIAVKASSFLLFSNGIAYNTAHSLAMLEILLRSNFSLPRLLPYPAATGMIGGILVLVGQSVRSMAMAQAGTNFNHMPAKERKEGHVLVTNGVYRLLRHPAYFGFFYWAIGTQLLVGNEVCLLGYIVVLWRFFSKRIRGKSFISFLRWGLIERFRGRGVTGVLFRDRLCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4X3</accession>
    <name>A0A6A7C4X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1741-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_212608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4X3"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="396"/>
            <end position="620"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="626" mass="69874" checksum="6CFD1752678B3A52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C598</accession>
    <name>A0A6A7C598_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">MBOAT-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">K470DRAFT_229438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="KAF2861878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7C598"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
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        </location>
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        <location>
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            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="557" mass="63047" checksum="8DE94762DDF36F93" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5A6</accession>
    <name>A0A6A7C5A6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_255689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5A6"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000008">
        <property type="entry name" value="Cx9C motif-containing protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="8818" checksum="85BEFD429B4AEFC3" modified="2020-06-17" version="1">MLPEEDVGNDPPCHAHACAIQACIQKNNYNENACQKQIDALYECCNLFYQRNGEDASTVSCPKASLLKLKMKQRANDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5E1</accession>
    <name>A0A6A7C5E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862467.1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tim10-like_dom_sf"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="83" mass="9234" checksum="5D8795E5F16510E5" modified="2020-06-17" version="1">MADAKQTLIEAVRQQTAMANTRMLVDKLNEHCFERCVASPTTSLGSAETSCVKNCIGKYVNSWDTVSKQYAGHIQRKTRLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5N9</accession>
    <name>A0A6A7C5N9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_212385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="595"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="595" mass="67620" checksum="35E0B0127E0762A5" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Q9</accession>
    <name>A0A6A7C5Q9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10267127at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="500" mass="55966" checksum="7106722E746C340B" modified="2020-06-17" version="1">MDSEDEPLSDVRARLIGDGELRKVGRNRGLLSKVTNKWREEEPEFPDAVKDESFWQMVWPSGAPTEKSPDTIKRKFWQRWPRTLLSLLHARRPRRALCMLFLLVIVIVTIVHYVRAPRRIDWDLSGFLRAQEKGTFGIADGGDFDGTFLKELSSDVLPGGPLDPKGQRRLIFVGDIHGCRSELQALLRKAKFDPAKDHIIAVGDVVSKGPDNAGVVDELIKHNAQSVRGNHEDRILSIASSLHPDSHTSVQGDKLSQLLPPVEAGVTSKNYFDDATVLRVLKQEHIRYLKRMPLMLRIPPLPLAVAEAKKSASVISSEIVVVHAGLVPHVPLLRQEPYFVMNMRTIDRDTHVPSALRQPRGGHFQPWSHTWNWYCDRVDRGKSLTKFYDFTRGGPPFVPKPKRKSANGKGASLKEATHRAKGKLAEVMDDALDTAKQALGKNKKVRPITVVYGHDSHSGLKLSRWSKGLDTGCVKGGHLTGLILDATGHTRLVQEVCREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5U0</accession>
    <name>A0A6A7C5U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_212265</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="248"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="555"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="627" mass="71767" checksum="F89F4FD47D27F553" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C624</accession>
    <name>A0A6A7C624_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5407645at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="39"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C655</accession>
    <name>A0A6A7C655_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_212101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:MAP kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:MAP kinase kinase kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:p38MAPK cascade"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:stress-activated MAPK cascade"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1323"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1326"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1075"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1351" mass="150811" checksum="05716BF31E5660D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6C3</accession>
    <name>A0A6A7C6C3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="181" mass="20990" checksum="F7D5B96D7275EED1" modified="2020-06-17" version="1">MFDKWPHGALRRTRTLQRKFCLRLSSKKALAMRHVTDRKENVFTTGGPGTGKSAILNAIIMKCRKRRLENLHSVAVTAIWTSLVLLLRSKGADRPWKMADYGDPCHRRGFHDRRCIVHDAGRTCPRHSPKRRGFWRYPSHRVRRLLAADTVQHEKQSQEVGFPKLGVEQGLRQDRRLEGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6R1</accession>
    <name>A0A6A7C6R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_280508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="236" mass="26688" checksum="286A37C4022AA25F" modified="2020-06-17" version="1">MSAAQDEFDQLMRSGQHRLKRTQSDDECSNSEEGASPEITTAQQRVGKSRDKIPKTRYQANTGPKGVISDAQDYADSRQRTQNGTRACDSKDDDDFMRKWRIGRLQELRSGRKAEIEPRQWGGMPTVDGERYLEAVDQSPSGTVVVVFIFDDRSQVSTVIEGCLRNLARRYADQTRFIKMHYCEAQMERAGVPALLAYEDGEKFATLVPLIDELPEEGEVSPKTVEAVLKEHNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6V7</accession>
    <name>A0A6A7C6V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_262332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6270329at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLX8"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
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    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="21653" checksum="FE56186BCA900F54" modified="2020-06-17" version="1">MDTNTRSRHRPGSSTGPVDLTASSPAQTRTPAKARPVPKRRVTKVTDGERDKKRRRSVKATTSTSPSAAATAPPSPLEAEPAGDDPQGEDEALRAEQLKSLTAQQTDAQPNSRLKIGQRTCIICMETFTNITVTHCGHIYCHECLLQALKIGERNAAGIGHCPMCRQTVRQKKGRSQGQIYPVSFMKRSEYKRRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C708</accession>
    <name>A0A6A7C708_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C708"/>
    <dbReference type="OrthoDB" id="5401962at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="68" mass="7919" checksum="CF4EE84A6D276CBC" modified="2020-06-17" version="1">MQETKALMVAGIPRILDKFLKFGKGKHWAGDSMSNHITWVKRMFPLVFDRRNATANDWPQPPERHRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C765</accession>
    <name>A0A6A7C765_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_210886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="35701" checksum="EDC66586519696C5" modified="2020-06-17" version="1">MFGYAPSFFYSQFLVTPPVPTTSCAGKTIIITGANTGLGREAARRYVQLGASKLIIGCRNLDKGRDAAEDIASSTGRDRSIIDVWPLDLTDYESVKKFADQTRELDRIDIVIENAGIHATKFHEVAGNESNITVNVISTFLLLCLLMPTLRKQKGNGITPTLTIVSSSLHFTTPFLEKNEANIFEALRDEKKTNMGMRYQTSKLLEVLALGGLAKQHPVEQLGVTINTVNPGWCHSELGRDMHSALFDVAKKIMCRTTEVGSRNLVDAGLRGPETHGKYLSDCQVEKRAPMVEGPGGDELQDRVWKELGVELEKIEPGVLNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A3</accession>
    <name>A0A6A7C7A3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_212336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7A3"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11971" checksum="60DAA99BEBC89018" modified="2020-06-17" version="1" fragment="single">MSVLRTLQAPRLNRKLSHPATGRVISYSDVGDPTGKAVFVCAGMGLTRYVSAFYEELASTLRLRLITVDRPGVGGSEPYPQSDRRGPLAWPDDIFVICQHLGIKELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7H8</accession>
    <name>A0A6A7C7H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_211380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7H8"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="208"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="348"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="657" mass="71232" checksum="BB2CC55D550F98D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7L2</accession>
    <name>A0A6A7C7L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_280179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7L2"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="68" mass="7709" checksum="7693171DA44E08BA" modified="2020-06-17" version="1">MDSAKVPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8F7</accession>
    <name>A0A6A7C8F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_209804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8F7"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21046" checksum="FF65A391207F5FDA" modified="2020-06-17" version="1">MSLSPTLKPLLDSSIWYLLSLWPAVEIACSNGWGGPESYSKKDWFAAEIVEYITNGQDGSTPREKQEDLEVFLLNVMADEFETVLEDESEVDVAAGMLKIYDDLLNGDSGAARQIKARWEGRGRLVTDVRVEEPEGEDGEEGEDVEDYDGDSDDEMMDVDDNAQKKKKREKPKAEVDEDGFTKVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8M5</accession>
    <name>A0A6A7C8M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_254885</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8M5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="13"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="454"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2863592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="631" mass="68862" checksum="A232CC95C52014EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8P2</accession>
    <name>A0A6A7C8P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76345" checksum="61786B97F30398B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8R3</accession>
    <name>A0A6A7C8R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_210058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="231" mass="26250" checksum="C5BCB1CF55CAD303" modified="2020-06-17" version="1">MTLQLASQDDLPSIVRLQLSSFETHPRFLCMWPRGLTPDLYAFQERLKRQNHGTIFKAVDSDHKMRGFAEWAFPDQSTRARVEEDEGRGAISKPSAWEAPPDDWPQGGNFPLTRHYKQTWLEWKGEKYGGGDVIELVYLAVAPDAQRLGIGRKLLRSGLEEADRLELPVCLESTPAGLKLYADNGFVIDKTVEASSELLGREVREEEGIGKRFYMIRQPRNALEKMNENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8S6</accession>
    <name>A0A6A7C8S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_268058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8S6"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="315" mass="34600" checksum="9290784F47287A32" modified="2020-06-17" version="1">MDVWDLAALRGQHEDITIDNFVQKAPDLNPAGSDKSKVIGGDVLCDFVSVAQKPPKAARTRSDNVEILFSTSVAQPEPTAAIPEPESESAPVSAAVAAPTTTNEVNMPDVDADADDAPNETVFPPESQSKRTAHITSKRSIPVPPHRFTPLKRDWSKIFTALVEHLHLQVRMRTHTRSIDLRTSRKTTSADALQRGADFVQAYCLGFELDDAIALLRLDDLYIQTFEIKDVKALEGEHLSRAIGRIAGKDGRTKFAIENATRTRVVLADQKVHILGAYKNVNMAKTAVVNLILGKMPGKVHGDLQKISARLKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Z6</accession>
    <name>A0A6A7C8Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Z6"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="85641" checksum="AE25B71648A4B9B0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C906</accession>
    <name>A0A6A7C906_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C906"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="113" mass="12430" checksum="9045E880455C5113" modified="2020-06-17" version="1">MTEAAFSNRGAINEEDTGDEGRARKSPVVRFKLPGSEPRDVLSLRETWKIQLPNSKALLRPEALEVAYCCPPGQSQRLDPFLVAVTDIHANGIPHGFLIWFPALSHLPSLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I9</accession>
    <name>A0A6A7C9I9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
            <ecNumber evidence="7">4.1.3.27</ecNumber>
            <ecNumber evidence="9">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_210543</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EC" id="4.1.3.27" evidence="7"/>
    <dbReference type="EC" id="5.3.1.24" evidence="9"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I9"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="20">
        <location>
            <begin position="247"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2863665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="514" mass="55600" checksum="3CED1E630856C9A5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N2</accession>
    <name>A0A6A7C9N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9N2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="256" mass="29727" checksum="38742554C2F2821F" modified="2020-06-17" version="1">MDVVREAIPKGYLEGIRKRPPENVPKSSSANFNMVSEETIEVYTRDRLRLRLQYLDSVENDKLSPPLFHTRIPIEIDLYMRLVTLRQPKYLANYGRYLGRTPEAIRSKLRATEENAPDPETAPTMLDRKSRKAWTKLYKELEGTDWKETKKHHSLAAHCLGYNERALGRLIDEWTENNQTLHDNVSLYINQGDWLALSCLLARDIRELLLVSLKDETASEHERVLLLICDEYLDLLPNEHAKKLAEAKGIKESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9X2</accession>
    <name>A0A6A7C9X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_261234</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
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</entry>
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                <person name="Bloem J."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAA7"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="539" mass="58602" checksum="BE9253931BEA8451" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAH8</accession>
    <name>A0A6A7CAH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_240399</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAH8"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="17">
        <location>
            <begin position="285"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2864212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="768" mass="85983" checksum="DD59C203AB065435" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAI9</accession>
    <name>A0A6A7CAI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_254076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAI9"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="263"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="753" mass="86630" checksum="5D67FFF20B5F5BFA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK6</accession>
    <name>A0A6A7CAK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_239693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAK6"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="216" mass="24002" checksum="C4E911672EEE58F4" modified="2020-06-17" version="1">MLRRIALSGPAGLRLSRTYVSRTTTDNPVPTNTPSVTPQTPVSATNDTATSPMGAKDKPLQESVATAEELRSWQAPNRKDVWSTNQRPRNEAMTGPRFEQMIMADQPLPWSAMELIHQQPVRWTDSRVVSCDGGGGPLGHPRIFINVDKPQICFCTYCGVPFAHEHHRKHLENLPSTTYPLENPNEEGTLPQSHTIRSSGSTEPLQSSTQKPLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAR5</accession>
    <name>A0A6A7CAR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_284085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAR5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="212" mass="24284" checksum="5CACD6EBAA29C2CF" modified="2020-06-17" version="1">MSITFAQTSKLQLQRLKTPRRLLMADNSASEAGYVTHFVQSWFQIGNHHWASNSVIFDSSNCCFNCLKDGQPCRLEGRSERAHKRYQATVEDCAEDKIGTLDISVLDPDSILAYCRSDGVYAHLVTLTELSEDRMDEDPITIHRLTQDDIDKFLEKQRRSPYTPEELERKIPKEHHGMLKAFSKQAANQLPPHRATDTKILLKQAMAPPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAW8</accession>
    <name>A0A6A7CAW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_254551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAW8"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2864229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="42991" checksum="52ECFCF43538E36F" modified="2020-06-17" version="1">MLSHLCVYHSYSGDFLSRFWLPFLFGSASLFFRQTNIFWIAIFPAAVRIIREMDRGHDAVRCSMLRKADGFGDSLYNVAKSSWKFDVVYDQSATDARLEDYIKTMASLAACLLKTLFNFRRLTNLLAALAPFIALLTCFTAFVVWNGSVVLGDKSNHVATLHLPQMLYIWPLLAFFSWPLLCPLSANSLALLYRQRPGIWVMFAAIGLACAAVWGNTIVHPFTLADNRHYVFYVFKRLLRPWWLRYAVTPIYCLMSWLVIRAFGDGPLTNNRLLLPDGQHATTTSFVLVWLTTSTLQLVTAPLVEPRYFILPWLFWRIHIPRGISTSRPRLRLFIEMLWYLTINVLTCYIFIDWGFQWPQEPEKVQRFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBA8</accession>
    <name>A0A6A7CBA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_1675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBA8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="18331" checksum="1F0635AF6DB48918" modified="2020-06-17" version="1">MCVTPQPFELIGLEPLAWRGMAPVPVVTDLHGRCRLLLQEALGGARNTPPSIILAHFIAAGAVGGMPDDYVIPRPRVPKPGKGGPNKSVDTVAWSFHLLPWANAAVACQISDFSSSFKVRKMLLEKGHKLRARVAIVVRTTSVSSCREPPPTPTFVSALPSTSALSIARYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNT3</accession>
    <name>A0A6A7BNT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane drug efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006071">
        <property type="protein sequence ID" value="KAF2857081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNT3"/>
    <dbReference type="OrthoDB" id="5575708at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1430">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1440">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1320">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB TolC docking domain, DN and DC subdomains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063:SF18">
        <property type="entry name" value="CATION EFFLUX SYSTEM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82693">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain, PN1, PN2, PC1 and PC2 subdomains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="Multidrug efflux transporter AcrB TolC docking domain, DN and DC subdomains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="998" mass="107576" checksum="9FE5A26E46826690" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNY7</accession>
    <name>A0A6A7BNY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_297302</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="MU006066">
        <property type="protein sequence ID" value="KAF2857111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="103"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2857111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1305" mass="140968" checksum="9EAC9BAFA4CE15E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP16</accession>
    <name>A0A6A7BP16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_223918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP16"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQY1</accession>
    <name>A0A6A7BQY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_260595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQY1"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="83"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="50520" checksum="673D884059E2DFB3" modified="2020-06-17" version="1">MASSRSAGVEEQLSKIHIQGVYSEDEPPKIIPDYLQPQALSLFARQLSTMSSVSSLQTLSDCLPLLKNPIRTCNLNRYGIPHLRREEHIHYIHSLLGTLPSHFQMLDASRPWLLYWTLNALSTLGENISSYRERLQATLQPIQNPTGGFGGGFGQYSHVACTYAAVLTLASVHGLELIDRKATWEWLGTLKQSDGSFSVAQGAEKDIRGAYCAMTVIALLNLPLELPSSAPARSAGLTTFTDKLGEWIGKCQSYEGGLGAAPGNEPHGAYAFCGLATLCIYGPPHESINKVLDTRSLTRWLASMQTGEGGFAGRTNKLVDACYSHWVGGCWSLLSAAQEDSSNRVLWNRSALVRYLLCCCQSTRPKLGGMRDKPSANPDAYHTCYSLAGLSAAVNTCNFRVGGSDASGARNLPAAFQWTARGATDAELEELLLERQDAVECVHPVFVIPFHAVEYAGRSFVGMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRB9</accession>
    <name>A0A6A7BRB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_266564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRB9"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="226"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="596" mass="66380" checksum="7D9F60409A7226D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRC6</accession>
    <name>A0A6A7BRC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_266542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRC6"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="206"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="331" mass="36115" checksum="19F7AF74CF8791DA" modified="2020-06-17" version="1">MANDIPPWGLAIAGSTGALLANALVYPLDIVKTRLQVQVKTDKSADHSDATHRHYEGTLHAIQTIIQDEGIAGLYSGMAGSLIGVASTNFAYFYWYSTVRGQYVSKVSKGKPPGTVAELSLGAVAGALAQLFTIPIAVVTTRQQTQPKHERKGILDTAREVVNSEDGITGLWRGIRASLVLVVNPAITYGAYERLREILYPSKKSLAAHEAFLLGALAKAMATIATQPLIVAKVGLQSRPPPARKGRPFKSFTEVMKFIVEYEGVLGLYKGVMPQIIKGLLVQGLLMMTKERVELLFVLLFQYVRQIRRDKLDKLVTATAQKIEEGRALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRD3</accession>
    <name>A0A6A7BRD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_223582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRD3"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24924" checksum="271F119CDC1918AF" modified="2020-06-17" version="1">MAFSGFLFLAWRLFEIITLIPVMGMLAWFVHQYVKANLLTPTYILVLFIVSVVALAWALFTTIAYLRARHDAAFVALFDLAIMGGLIAGVYYLRNIAKQNCTSLRAQRQNLGGSISYRADKQCVMLKAAFALSIINIISFFITFLLALLVHRHHKKEDRVVVKRQYRGSSRHGSHHSRSRSRSRDHHHRSSRDYDYRPSSRHHSTHRSSRREYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRH8</accession>
    <name>A0A6A7BRH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_296825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006026">
        <property type="protein sequence ID" value="KAF2857841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRH8"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="394" mass="43794" checksum="53F2CACBC6F559CE" modified="2020-06-17" version="1">MAPKKQQKEEKILLGRPGNNLKSGIVGLANVGKSTFFQALTKSNLGNPANFPYATIDPEEARVIVPDERFDWLVQHYKPKSQVPANLTVYDIAGLTRGASTGAGLGNAFLSHIRAVDAVFQVVRCFDDAEIIHVEGDVDPCRDLDIISEELRLKDIEFVEKAHENLVKQTRRGGQTLEMKKLREEQATVEKVLELLKSGKDVRKGDWQPKEVEVINPLFLLSAKPVVYLVNLSEKDYIRQKNKHLPKIAEWVKEHATGDPIIPISVSFEERLTRFETEAEAQEECNKLGTKSALPKIITTMRKALNLGSFFTTGADEVRQWTIRNGTKAPQAAGVIHGDFEKTFIQAIVYNYSVLKEEGDEASVKAKGKVMTKGKDYVVEDGDILLIKAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRQ6</accession>
    <name>A0A6A7BRQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006060">
        <property type="protein sequence ID" value="KAF2857188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRQ6"/>
    <dbReference type="OrthoDB" id="10261737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="94525" checksum="68B0135AC359C69B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRT6</accession>
    <name>A0A6A7BRT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_200913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRT6"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="430" mass="47320" checksum="82ADB9A06E03761B" modified="2020-06-17" version="1" fragment="single">QTYRPKHQVVINKCYPRLPKNSTIDAKPNGSELSALCFYMANRPVKLPKVASYLERRTAREVAKQQSAPVLVTLQILSALMQINVVDGSALALIAPYLMRILSLILSRAVDVSLFEASCATWDVFCQHQDMAVLEGKSEYKLLYEQVLRQYASLGSKHTGKRLGSSTSPVEAQTAMRLRRVGLSALLSVLRSETLALESAQVLHDTIVPAVISNLRGDAKSLSRLFARAREGEEEQKSPRASMAANRDEVPADPRAAEGSIKDADDLEEEKAALMAVACLKAIFNTSCKPLLHAGAGATLEVLGRDPDSQAWAVELFAQCAAWTAVQDRFLVVVVAINRVGQLENMRQQYLLLAIIEHIFHSDLNLIGLSIMDVLLGLLSQTARILREGSESNPAMLEMLQKCVAHLATHVYYQEQITDMVSAILTRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRW4</accession>
    <name>A0A6A7BRW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_200694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRW4"/>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7371" evidence="1">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="19291" checksum="F91D94987A8B7DD7" modified="2020-06-17" version="1" fragment="single">DIHQFPPVMRPYKHLTFSDGWVYASEAREPFTPRSSPNVGVLLSGSIKRTMTVPLGRISTGPYRALSAFWFDAFDGWFGCVTFGIGPCTFAIQGYVFDRNLGEELLAFAKNQTVPACEQARGCELRLIEFPPIFRGLSALQVKAYVGDMEQAFVMDDLHLGWADQSCEAGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRZ9</accession>
    <name>A0A6A7BRZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_170781</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRZ9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="85"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="407"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2857535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="660" mass="73129" checksum="B63162E932B91C04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS60</accession>
    <name>A0A6A7BS60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_252144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS60"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="11086" checksum="D0E6E2C3A57A753D" modified="2020-06-17" version="1" fragment="single">MSPQGPTLESLIQSSISAKSKAYCPYSKYRVGCAILIDLNGKKEVVIGANVENASYPVGTCAERVALGAGVVNFGVRGPWAIAISSDSEVPASPCGMCRQFLREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSI4</accession>
    <name>A0A6A7BSI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_222457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSI4"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="341" mass="37985" checksum="1898195BB3F8D642" modified="2020-06-17" version="1">MQSRRRGHSPKVLIMGTKNSGKSSIRKIVLEKLLPADTLFLEPTLEMESSTLHSFITTEAIEIPSITASNTPPPSHTLPPVLCTAPINLSTIGSIIWLIDVQDELLPSITSMVQIAVYLAEYHPRVNLEVFIHKVDGLTDEYGWDLYREVRQRAQDELGDSGFDPANRLSIAFHQTSIYDRTVFEAMSRVVQKIIPQLPGMEALLNKLCSTCRIQKAYLLDTGSKLFVATDASPTFTRDYELCAHFVDVVADIKQLYDWREGVDGGDGDGDAHKEEDSTAIGESTLTYDPAGETFMYAREMAPALSLVCIMGKGCGPQQRVRVDYNVELIHEALLAIFYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK4</accession>
    <name>A0A6A7BSK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_201699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSK4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="386" mass="43242" checksum="24E231B5CF7A01D3" modified="2020-06-17" version="1" fragment="single">MESNRLSTPLHNPHKERQIKDAQDMYRAIVRSAERLKSKVPPYDFIELIGKGGFGRVYKCREQETGQLVAVKIVATDEADFIEHTLDRDSTIESFRKEVSILQQLKDSKAKNVNMIHDAFDLHSQLWIVSDYCTGGSLRTLLRASPANKPGFDERYIIPIARELAIALKSVHDIGVIHRDIKCGNVYVNEEGQIQLGDFGIVGIIDDGVSKRRTIIGTPHWLPLEINKGMSSNEFKTQEAYGTEVDIWSYGITIYEAATGHPPNQTVRQAELGAALLTAPRLEGAEYSAELKDFVAFCLATDPKQRPTADQLLKHPYIANTAHTHPTSNLIDLIDRYAAWEYKGGQRASLWFAGGAAGPSEESPRIEETQEDWVFSTSDHFTKAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK6</accession>
    <name>A0A6A7BSK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSK6"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="474" mass="52027" checksum="8B35A134F0C63138" modified="2020-06-17" version="1">MPKSARSAAPSPSQLTTADSSDWEHVDNEGAEAEEGETMPSDLRSSPRQFSHIPLLAGHNKPEDASPTTRRKRSSRLLDEDPAERARESTRRRYTYAACFLALSLVTFAIQTETAVYIQHDLQWNKAYCMLYLTHSSWSLLYPAQLLILRFGAWQQPWPAFWRRHLQLLRQTGQMVEHQRLTLTPQQQKRSPVPYLVRTTAYVACALTIAGGSWYVAVDLTTASDLTAIYNCSAFFAYVFAVLMLGEKVKLSKVVAVAVAIVGVLVVAYGDKHSTAKHGSKSGGGSGGPNVPSDDEAENRALGNIIIGGGSILYGFYEVLYKRVACPPEGCSPLRGMIFANTFGSMLGCFTLLVLWIPIPVLHVLGWETFALPRGQAAWMMLISVLANATFSGSFLVLISLTSPVLSSVAALLTIFLVALCDALLPPPLHHRLTSAAILGGLLIMAAFMLLSWGTFREMAEEEKKETIEMEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTD5</accession>
    <name>A0A6A7BTD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_289401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="155" mass="17033" checksum="3CEFC6E4E958B448" modified="2020-06-17" version="1">MGPIWFPRDILKNSRELAGVDWEYGKVRIISQSCGGSLGIQAGEDALIISLTILLIFSQLLQPEKTDLNDVCIGGLPWRAVIINEEHHGLPPEQANFINALIGVLTRWATKAIDVGNKPFKALDRGGQRFVAIHCYECSGYLAGSDQNDRGHAHL</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="52"/>
            <end position="337"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858660.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="406" mass="45099" checksum="DE051E058CB4F0EA" modified="2020-06-17" version="1" fragment="single">AQDVIRGVNLGGWLVTEPWMTPSLFRATSTQDEWHLCSALGKDKCYALLQDHWSTFYTRDDFVQIKKAGLNSVRIPLGYWAVDLLSYEPYVSGQYPYLINAVRWAKDIGLTVMIDLHGAPGSQNGWEESGITGPVEFPANQTNTDRTIKVLKNLTDEFSQSTYGGAVISIELLNEPKMDFTVLSNFYSAAFETVVAGNASGINVTIHDGFFQPHSWANYHPTSAAATESAEYLSIDTHQFWAFPPLDNLTKPEILDAICDFGQQQLHMTSGKYTGILPTVVGEWSLSTGITGNSTTQSQNDPEKRTWFRTLFEAQNAAYTPKGPGQPSIGWYYWAWKTEYDIDAWSYRRGIAEEYIPSDVSDSSKFVFPIKPNGCIDETFHYSAPKSVPTYTASDAVPSSTSTATG</sequence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUF7</accession>
    <name>A0A6A7BUF7_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_196876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="378"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="587" mass="65587" checksum="CCDCD4B0D7277409" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV25</accession>
    <name>A0A6A7BV25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_113927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </feature>
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        </location>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Goodwin S."/>
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        </source>
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        </source>
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        <source>
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        </source>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <source>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="25531" checksum="49A70868AE26CF5C" modified="2020-06-17" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRANVDEFPCCVHLVSNEYEQLSSEALEAARICANKYLVKVAGKEGFHMRVRAHPYHVIRINKMLSCAGADRLQTGMRGAFGKPNGTVARVNIGQIILSVRTRDSHRATAIEALRRSQYKFPGRQKIIVSKNWGFTPLRREEYIAKRQSGQVRVDGAYVQFLSNHGPLEHNMRNFPQAFEQQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWX8</accession>
    <name>A0A6A7BWX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_218459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWX8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="302" mass="34782" checksum="B55834225B26C689" modified="2020-06-17" version="1" fragment="single">MRLLDARTYKLKEFPDDALPPYAILSHTWTENEASFEELHHASKVRVKVNRVYKKLAGACFQARKDGLDWLWIDTCCINKDSSGEWTEAVNSMYRWYENSEACYVFLDDLEGSCPVLSDSDIEPSPQSRESLSQRMTFWSRAFANCRWFTRSWTLPELIAPRRVKFYGKTWRLVGTKATLVRTIARITGVDVGVLTHYRRLTSVSVAQRFSWAANRRCARVEDRAYSLLGIFGISMSILYGEGNRAFARLQEEIMRFTVDLSIFALSVETSDNNELMAESPDNFSDSKDIVSWGRPQGFHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWZ5</accession>
    <name>A0A6A7BWZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWZ5"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="242" mass="26609" checksum="089DA872218CE7C6" modified="2020-06-17" version="1">MAPLLVQCVLNPPALKYGYGLRNARELQNSSATFGMANGLGTGKASRPGASSRSTNLVATETSDFSDDLQSFATAIEEGRVFKSQTLGGRIAQQQPRGERYFVGAFRGDELHLTQVDGTIVLNPQFHNVDALAQQHSLGIASAAAAAARERGEEVAERQPRPVKLPERKQDQSQRDKFEDNMRRMLTNAELENWVDVDFVDEEYNAAYQKFGERLFVNNGQIATRLKCAETVEGDATVGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX36</accession>
    <name>A0A6A7BX36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_95994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX36"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="101" mass="11458" checksum="1F6CF3C1328FD03B" modified="2020-06-17" version="1">MFIPAHFLTAPEGEVSYLILLIFLTRSSVPEALYAETSWAPGCLCWRSCLSRTFAGGISARPISSEAMARERLWEEMTYMAPCDIETQDPIANPLNQWRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXC3</accession>
    <name>A0A6A7BXC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_271112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
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        <property type="protein sequence ID" value="KAF2860016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="11"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="47"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860016.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="749" mass="81446" checksum="F2B064F2E7CB87F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
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        </location>
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            <begin position="26"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859864.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX3</accession>
    <name>A0A6A7BYX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2859909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="167" mass="19273" checksum="D9FCA8517B091DF6" modified="2020-06-17" version="1">MGTNHLTTFQFFTGEPFPAMHVLHSDLAAFGMSESFENCTMQAEPTPTIPQVPQRLPYQEIVSAKINPEQHYNPDMVVTWYRHVLSNHLGTDRSVFNSVTCKLQVGFQHGKPNDWRALFDWVAKQLIKMWRRYEIYYGQFTTPTAKVAHAIADFFSWEASSVMQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ50</accession>
    <name>A0A6A7BZ50_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
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    </gene>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ50"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="528" mass="59145" checksum="F0787070CC5CBD55" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZC2</accession>
    <name>A0A6A7BZC2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_247022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005979">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="224" mass="24377" checksum="7C3C2471EF69E73C" modified="2020-06-17" version="1">MSWAIAISYYRDGDLHAYLTSRIANSGTQPPEPLSKKLAIDMATALGFMHLGIADISQKPVLVKGHIPILHRDLKPENVFVRIEDSVPKFVLADFGLANFLPEAVGVTGTPGYIAPECQKVSDELDEEVAERVRVHTAKSDVYSFGAILWSAVTGLPFDNLETRYSLKRMGKHLKKIGVEATGGTVGALVLGCLEKEPAERLGTEQLVGFARRFKGELGPGVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP4</accession>
    <name>A0A6A7BZP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_232170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZP4"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="817"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
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            <end position="279"/>
        </location>
    </feature>
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            <end position="451"/>
        </location>
    </feature>
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            <begin position="747"/>
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        </location>
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            <begin position="1"/>
            <end position="16"/>
        </location>
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            <begin position="24"/>
            <end position="33"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119538" checksum="33CB673A2992B10F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZS6</accession>
    <name>A0A6A7BZS6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
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        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_77756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Importin_beta"/>
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    <dbReference type="PANTHER" id="PTHR10527">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2860229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="870" mass="95456" checksum="D32380760CE6A6F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZX3</accession>
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        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_247548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="34137" checksum="0B67E49F1175D5EE" modified="2020-06-17" version="1">MRLYALGSNGSGQLALGHQRDVSVPEKCHLPADIINNGIKQVVAGGNHALVLSRTGFVQAFGGTNLSLENVSMISATWTASVCLKQAGRVATMGDGLNGELGLGMGISKAKEFCDIPDFPPQGASVVHVASSMSHTVAVLDNGEVWGWGKGRHGQLGKPNQDAWLPRKVQDVPFPVAKAVCGKDFTCIIGEPAQGNLLILGIQGRDRFGLKSQIATQVPGWTDIAASWGSIYVLINGRLIGFGRNDHGQLPPPGLTPIVQIAAGSEHCLALTKCGKILAWGWGEHGNCGQPIDSNGDVKSRWNEIDLVSPTAIFAGCATSFIATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C018</accession>
    <name>A0A6A7C018_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C018"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="7731" checksum="9BE266970673A242" modified="2020-06-17" version="1">MCGVEYESLAYAEKMRVAVKRPVLYPVFSPAEVARIGFEIHCIMLDSSIAASAYAGHLHSKSAIPPTLPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C049</accession>
    <name>A0A6A7C049_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_217165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C049"/>
    <dbReference type="OrthoDB" id="3943081at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="13402" checksum="D45260254E490B2B" modified="2020-06-17" version="1">MITTKARAMRLGAGLPVYLWPLPVQGVAYLLNRTPVKTLDWESPLDALNQKPETITHLKAWGCKAYPLVHLIPRTHMQEPRVNIGYLVGCRSRNSFRFGFPSCVKSFVVKKYRCDNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C098</accession>
    <name>A0A6A7C098_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SecY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_216170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C098"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="476" mass="51950" checksum="6A392F93002308E5" modified="2020-06-17" version="1">MSGLRFLDLVKPFTPLIPEVQVPETRVPFQQRIVWTSVTLIIFLVMSQMPLYGIVSSDTSDPLYWLRMMMASNRGTLMELGISPIISSGMVFQLLAGTHLIDVNLDLKADRELYQTAQKLLAIIISFGQACVYVLTGLYGPPSDLGAGVCVLLVVQLLVAALIVILLDELLQKGYGLGSGISLFIATNICESIVWRAFSPTTVNTGRGPEFEGAIIALVHLLVTWPNKQLALKEAFYRQNLPNIMGLLSTILVFGAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALSSNVFLISQMLYNRLPDNLLVRMIGVWEARDGSAQVLPASGLVYYMSPPLSIKEALLDPLHTAIFTTYMLVACAAFSKAWIEVSGSGPRDVAKQLKEQGLVMAGHRDESMYRELKRVIPTAAAFGGACIGALSIVSDLVGALGSGTSILMAVTIIYSYFEIAMKEGDMAGLKGMVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0N0</accession>
    <name>A0A6A7C0N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_276511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="291" mass="32692" checksum="324B6CB650CFD717" modified="2020-06-17" version="1">MLFLLTIIATALAVPAENKWSRFRFTSLVSFGDDFTDDSRWSYYVSHNYTVPPVGWVNPVNYHAFDGGRPWVDYVKQYTGCNLYNYAISNAVCSSYLTPVTNNVPERTLPDIEAYQLPTYVAESKKKIPGKPFLNVPQASTVYAIWIGSVEWGEFVRGNPWNRSVDDAINCIFNQVKRLYDTGARHFVVFNVLPFDKTPVYAGPPNDVGPTWYWSTKSEDHQNVTDITISIDEYGNQLYAAKRLDLPGAEVAIFDIHGLVEDMYENPSKYLNGTAPANSTGVMASSENGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Y2</accession>
    <name>A0A6A7C0Y2_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_294978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Y2"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="278" mass="29755" checksum="F2FDB67EBCBC6AD3" modified="2020-06-17" version="1">MSKLSPALKSLIHATHARAGTTPAPYGIASVYRGIAADAKRLNVGTNAWLTASAAATFTLNSPQSLLELFRVAVASQSNDAALSTAELIREIGLKCIGLNGVPRTINTLGSFYDSLDPSLQTRLSERRPRRNLNKANIDTTVARGEALWKSIYLPYEGKLFDKLATYHPDLPVFIVQGEYGALFSDPSVETAAQGPEVGRVLMSILAIACLRAQTGVGPQVTSHIFGLRKAFEDGTAESEESVPGGKWLASDDGSIWLLNVIDEIVAEIGQSFAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1E1</accession>
    <name>A0A6A7C1E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_257956</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1E1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="37"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2860508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="611" mass="69974" checksum="58B4A6214601D738" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1M9</accession>
    <name>A0A6A7C1M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="MAG2/RNF10"/>
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        <property type="entry name" value="Znf-RING_euk"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_1"/>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
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    </feature>
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        <location>
            <begin position="404"/>
            <end position="421"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="659"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="671"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861476.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="671" mass="75068" checksum="2FD4513820F7D1B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C215</accession>
    <name>A0A6A7C215_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_230662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7C215"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035556">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Kinase associated domain 1, KA1"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMPK_C"/>
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        <property type="entry name" value="KA1/Ssp2_C"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="53"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="576"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="660"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="820" mass="91139" checksum="3ED0E9FC1DF43612" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2A4</accession>
    <name>A0A6A7C2A4_9PEZI</name>
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    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C2D1_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="634" mass="69139" checksum="316FE758B8A176C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </source>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
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    </dbReference>
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    </dbReference>
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            <end position="35"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3S5</accession>
    <name>A0A6A7C3S5_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_285329</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2861615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="793" mass="88625" checksum="B78B79831F5794F4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C490</accession>
    <name>A0A6A7C490_9PEZI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C490"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="38762" checksum="93CA1A00195E33AE" modified="2020-06-17" version="1">MSRVLLTGGSGFIAAHILECLLQRGHRVVTTVRTQQKAQKIAERYSNYGKDKLDFAFVEDIAAPNAFDKAVVSDPPFDTVIHTASPFHYNVTDIKKDLLDPAINGTKGMLQAIYSHAPTVRRVVILSSFAAVINPTKGNWPEHTYTEADWNPVTLEEAMQRDASTGYRASKTFAEKAAWDFVHEMSPRFSVTTICPPMVFGPPIHYMASPLKDLNTSNCLIRDMMQGKHKTEIPQNGTFIYVDVRYLALCIVIAMERPDLVGNKRLLVIQGYFSNKEIADILRSSFPQHKDVLPAADAKGGNYPPEGPYKYDSSRMKQLMGNQGSNLLVNGKAIKDTAQWLDTVGVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4G8</accession>
    <name>A0A6A7C4G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4G8"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="290" mass="33568" checksum="B38BC78700DAB986" modified="2020-06-17" version="1">MLTRTVYRAIPRGTTRFACRTPFRRFPTQRVQAFSLSHSRFDSASQQLAAKLSQEAQLESNEMSKTNNLDVKSFLEKNPGWKISDTTGTGEVIMERKYEDEDITVMFNVSEADNSLGPDEEMEDEMSDDELDSDEINSGTSDKFKVVPEDRMDQRYEESDSKAETLEEEDWDVPIPAEVRVLIRKRNKGALKLYMDTTDSFFHINHVVHLPDSKEMHSTSAVELLRKDTDGVYTGPLFPHLDEEVQSLFHKYLEARGINTNLSMFIPDHVIEHEQKEYVDWLKRLQSFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4I4</accession>
    <name>A0A6A7C4I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4I4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8302" checksum="A6F8EA06233FC20F" modified="2020-06-17" version="1" fragment="single">MWKGPVRPRPESSGPTLRAHTQAALTFLFSSSCVVFCLHRVYAVLSSIAHCSGPVTLGSHRSLDPDPSSLASCRDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4J3</accession>
    <name>A0A6A7C4J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4J3"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="52180" checksum="C0494D534AE68968" modified="2020-06-17" version="1">MPPRLLYIASKPPISISQPQCCLYLLSTTSKGPKNRISRFRASLGPRTVHSAKFSSITSKLNPGISPRKNTNAPQPGKPLPSRDVEEEYTPKSALLYTTHSSSLPPSADVNPPRSLYPPPLVLPREGGSRIIRLYGLGRAYAKFYVLGVKAVWFNWKAAKVIRERLRGKGGPSGSKLRESRRQTGREDGSQKTPSLKPSINSKRPNQQKGIKETPHFPRSMDVMPGGSLPQRLNLTRSENLILTLSARDVGKLPLFALLALIFGEWLALIAPFITGLVPSTCLLPAQINSIREKNRLRRVHAFRDGVVEPTISVGPDEVAEVAELRGPAASDPPRKDWATTERSVLQKLVSEMNREQLYFLSRVLALHGHSWERCGLIPPRWLLRRRVSKRLYEVGVDDFLMVRSGDINLLEEREVEGACEERGIELGYLGMWVDLQRRDRGRGGAMVKMLFRRGRVWGDIGIEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Y8</accession>
    <name>A0A6A7C4Y8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_268902</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="620" mass="69893" checksum="E314414591B76994" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5A2</accession>
    <name>A0A6A7C5A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_15200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5A2"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08585">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="224" mass="24430" checksum="A71B1C6E1A391C4A" modified="2020-06-17" version="1">MSSDGAELASQITEFLASKQVPPNGAWMQMLMQGIRADTPLVGLRNTALFRILASDLQTSVRPSLCFPANVTDATAREKSVRGPVTVQVLDVEDIGRSRWSQVEAIEAAQRGEVTRGREIIPAAPDEHDETPALPSFTGPHKLLLQDAKGVKAYALELAPVNKVGVDMAIGSKFVLRNFTVARGLLLLEPCNVEYLGGKVDAWHQKWKDDRLGMLKEKANMGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5D3</accession>
    <name>A0A6A7C5D3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_212062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="12010" checksum="2AE5FC0099FB5FBB" modified="2020-06-17" version="1" fragment="single">MPRFFTGWETWEKLTFCLAGAILLTFFAGATKVGYTHWRLRKYTAIAEKERKEQMIQRQVMHEQPFPAVDDEIPFGIRALESGVEVEGIWVSRPTTPDSKSQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5K2</accession>
    <name>A0A6A7C5K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfate transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_242747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="157" mass="17556" checksum="9E1C99D57E0E30CE" modified="2020-06-17" version="1">MTSNTNCTVLQRSSNIHLVSDTPKGRAIYANEPIPSGTIIDTCPVLVLPSSEEEFIRKTQLWHYTYHWPGSDPATICQAVVFGLGSLFNHSRRNQNVGWMRNLEKQTITYTALRDIEKGEELCVSYGDDLTFEDVEKDEDDGENEGGGLMDIEIGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6X9</accession>
    <name>A0A6A7C6X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_255393</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6X9"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="720"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="889"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2863271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127078" checksum="2E0B8B4182F62A1C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C706</accession>
    <name>A0A6A7C706_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_155559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C706"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="27983" checksum="E41E4BC801EBCEE2" modified="2020-06-17" version="1">MTTKTGCSLEKYNPTPDGDKKLLEKDKILSMFREINAWLPPQCVRYRRQLCGKRSLFLISGAWSSPELKNHRTREHKPIREGLKNVIHMDICAQSSQTQSKGTNAVCSHKRILGVITEATQCKTTASSNKFILQIQLGELLQMDKILVTNRGSGYTRMRLYTRWQRKQTCASAVPVIRQIRTGRWRVFEQGAHSLGAYKIYRRQILTIWTLAVQYFCRIAKPDPDAYMGNRSCPHIQLDKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7K7</accession>
    <name>A0A6A7C7K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_125450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <begin position="60"/>
            <end position="81"/>
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        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="273" mass="29766" checksum="40B8A3A1079D5BA5" modified="2020-06-17" version="1">MNLLCRRLFHPSPWRRIPSKPVNAPPPPSKLYRAPSAPTERLFQCGPEVLIYRAASNRGYAAFAIVGGSMLLLGAANWAFLLSNITKESEGWTKHLTSLTAGATTVFLGAMGTAMILGPCAVVRSITARAPAKGKKEPLLLIRTQATPFSRVRTWETQPHDTFIDGRVAGNQIDYTSLTLDKATAAATDEVNVTARPSSTGNAVPQIVGHVRRLFYREGVAHLRMGQRGKTWRLNLASCEMLQGGMALEQLSKQDRLAGTGPVAWLKRSYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M2</accession>
    <name>A0A6A7C7M2_9PEZI</name>
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            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
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        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_210273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
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    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
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        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
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        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
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        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="275"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="704" mass="79174" checksum="D21D1551F3870169" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7C7W8</accession>
    <name>A0A6A7C7W8_9PEZI</name>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10800" checksum="35EA39CBEDA59001" modified="2020-06-17" version="1">MRLQPTFLSWKVTSAFHLLSLLGSYTNTNGYPCLNPSVNHVCSHHDHHLRASCTFSFNRYAKCWYMMECVHGDLAQRHVQYGHGEWKQEQYP</sequence>
</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="339" mass="36979" checksum="79084F307BF2603D" modified="2020-06-17" version="1">MHYIRFLKVPRVVRGCVEAMVTVTTDLGETFYPLAIGLVVCLEGDKGEGVCEVKVDWKGKGIRSVSVLMPIGKSVEWPARIHAYAGKGNGFLEPIIGIWSGGLDPRCGQYDSGWRVERRFITEHDESICLYEEAGDSIARHLWDGSQALARFLDRAISKGTGALATTQRLLKSPVRAIELGCGCACVGLTLALRCPGSDVLLTDMEEVRELAEANISLLKDKRSRVSFNALDWEEAVPQTIIDRQHNLVVVSECTYNSDTLAALVATLSSLIADSPKALILVATKTRHASEAEFFPLMKQAGFVINESIRLPLVGEPGSGYADSATDVGLYEFLWKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C822</accession>
    <name>A0A6A7C822_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025647747" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="12836" checksum="6DB987C21CAED613" modified="2020-06-17" version="1">MSFDAVDVMPLSRIVLLICAVVHTLQSVAPKQDISDRDTCTWCCTACAFDVTWSTANFAAGNHETSQVKVPQDKVWQAVLVPGHPPQSNVLTLNVPVEDSMVMGFDSVEVMDVVDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8G4</accession>
    <name>A0A6A7C8G4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5419752at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19671" checksum="D182936A9723CFAF" modified="2020-06-17" version="1">MVYLRTGDEWRKQSERLLHARPMARVTAKYKIAPSSPRGSKKASKKETLHIPEEKEKVERAPRAFLTLKTYDPKSGVTLKFKTCKATDLGRLIAEMDKLGCRMAGMEDSVLDHIQDQDVDMADSIETNGARSKGIDKTATEKDQSPVVVPQTSVRANKAPTQTSTSGVAKKKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8J0</accession>
    <name>A0A6A7C8J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_104340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8J0"/>
    <dbReference type="OrthoDB" id="3894609at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16248" checksum="3A95E72A1A1A6FBE" modified="2020-06-17" version="1">MAFSNFRRTPCQFIFLTATLPPSMWASSSLFNHLSGTETVVRAPSNRLNTRYTIQRISGSFLDSVVRTACDAWSPDLTMEGKAILFAWTVEDAKVIPSMLCPTLPAAETILSAVKSFKIGSWTPTAFHRRDNYAGRRLLHPPAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8L8</accession>
    <name>A0A6A7C8L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_227377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8L8"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="21524" checksum="A97EF0887D670D60" modified="2020-06-17" version="1">MGRKLKYHEQKLLRKVDFVNYPRDAQHRSAEVIRRYSVTNAADYQSYNRIAGSLRQLAHKLTQLPPESEFRRKHEDLLLEKLFDMGLLKTGGGGKGKLSDVERISVSAFCRRRLGVVMTRLRMAETVSAANKFIEQGHVRVGTEVVTDSAFLVTRNMEDFVTWVDSSKIKRTIMKYRDKLDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C965</accession>
    <name>A0A6A7C965_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_202326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="636"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1296" mass="145458" checksum="0B70852B432647CE" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9B0</accession>
    <name>A0A6A7C9B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_209333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9B0"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="216" mass="24122" checksum="C4946AD8EFCEC094" modified="2020-06-17" version="1">MWASYFHRSAIREAEDHYATLGLTPSATPSEIKKQFYKLSKAYHPDLHPDNEAAHRRFVRISEAHSVLGSPESKARYDREYFGRPAASSASTPKGSHSSAAGGRTPGGLSKRRGPFRGPPPSFYRNGGWNASSQSQSQSKQADMASSRHGSVEDDLSHFDRHGHYRTHETIEKKRSGRVRKREVEHQDDAFDFVTVSAVLCFAFGVAGAIWSWDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9B2</accession>
    <name>A0A6A7C9B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_142418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9B2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="193" mass="21811" checksum="700CA2B289EF3DC7" modified="2020-06-17" version="1">MKVYLLTHSSALLIMMTSHHDRLSGLGSKAHLWLYSPPNIECLRSVSCKVLGVRDDTSKSLLYNDVPHECPHFASVFSPRTYIMHTGTIRRIHICTHAWTSHNTPHALSSAQEIFYYSRLWFPNGLHTVLLSQSRSLLCRCSNNSLIRSSILKIDTYPANERTSGIPFLRRIEASGETAYKTIAALEAAKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9C6</accession>
    <name>A0A6A7C9C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_210359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="38"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="23085" checksum="F41082352FBBABF3" modified="2020-06-17" version="1">MRALKRPVQSFQPSRSFLTPPSFSKGLQTISTSRLLRFPPELIYDVISDVEKYRLFLPYCLESTVTKVSRPAKATGKSYPEEARLRVGFDGGLSEDFWSRIYCVPGKSVEAVSGNAEAKQRKEVEHHSVRAQDGRDPSRSTSVLSHLWTQWTVKAQPPGMTKVGLDIEYEFSNPFYTMICASAAPKVADKMIEAFEKRVHALNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I5</accession>
    <name>A0A6A7C9I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_267650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I5"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="534" mass="57869" checksum="29B8CC5CFB548AFC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9M9</accession>
    <name>A0A6A7C9M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_53919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9M9"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="76210" checksum="38215B5CC0E4BBC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N7</accession>
    <name>A0A6A7C9N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_239103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9N7"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="49"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="384" mass="41805" checksum="358A99E7EAA97541" modified="2020-06-17" version="1">MAFNLSTCARPNILSLTPYRCARDDYKEAPGQILLDANENTHGHSLSPSEGPLNRYPDPHQNELKQAICALRNENPTNPLTEENLFLGVGSDELIDALMRAFCVPGKDKIITTPPTYGMYSVAAKINDVEVLTIPLEGDDFSLQTEKIISTITNPPPSESEKGRVKLVFLCSPGNPTGVCIPPSSIKTLLSTPFNGLIIIDEAYIDFSTSTPSLAPLVPSYPNLIVLQTLSKAFGLAGIRMGIGFAPKNIAAMLNGLKAPYNVSSLASRAAIKALQPAALENMRRNRDDILQQKGVLMDVLPGIKGVGRIRGGKDANFVLFEVCDKQGRSNEFAKRVYATLAQRGVVIRFRGEEYGCEGCLRATVGTEEENKWLVKELRDVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P1</accession>
    <name>A0A6A7C9P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_124170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9P1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="155" mass="17439" checksum="B490BDC7293FAEF1" modified="2020-06-17" version="1">MLDALISSQRFHRQASCAPALRSLWQSSLAQRKAGWRKHRANTRMQTGGVIYARDVGSEGHGRFGRVPQEVQVCELDWGEKIHLMRLKTVVHPAMKRSDLTKTIAAIAEGKRRLEGGDGGSDVDCRPDWTIWFNSGRGRTKKTAARDYPKRWGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA20</accession>
    <name>A0A6A7CA20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2864062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="41953" checksum="D92EEBA67D96F04F" modified="2020-06-17" version="1">MRTRPNLFNRLPLDLLPDILWNLDVRSVQSFRTALYADKQPNNEAVLRVLESRLSVARYLNLTFGDGAKLLDAMSKSFVYLSGLRATNFFVQTSSTQHDQDSSWNFYLPQQTQYVGRFMQSLSELGVEWTKPEEEFYNFITENRSGRMVVDAETYEHFIMNGAFIHAAMKYKLNIKLPRVHEEKEKYVLLLNRRTIRIASHEEWSGQELNRHVSSIIHGRLIRKGKPTAKICLFVGKTASPEKFRAPLGFTSSYAQAFISPCVACHLYGELASRGQGFIWDQPQPQLQDQERGNFRALPVSRSSTRLRHCGDNEATWLEFGTNANAPPEVTDFVNVAKRLAWCESKAKTVPFEISLIGAPKPAGGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK3</accession>
    <name>A0A6A7CAK3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAK3"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="12929" checksum="2EF065C7AAB896AD" modified="2020-06-17" version="1">MFAAWIVATIFGTVIALSHRYRSWEDYKAENADKDMRTKARYEEKRAAERKAYEDNRRKRHEARRAKRTQEGREAEERLKARRERERKWFYGVDEPMGDYRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAL1</accession>
    <name>A0A6A7CAL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">K470DRAFT_209586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAL1"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025618185" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="247" mass="27780" checksum="60A6487A2930C03E" modified="2020-06-17" version="1">MAALVTLLVGFTLIAAASAYRLKRLTNPQRRRPSCAGQDTHLMIALGSGGHTTEMLTMLMRAVVTEPRIKQRLCWNKDYSHRTWVVSSGDVISVNRARHFESTVAKHLGEQSVDYDIVAVPRAREIHQPLYTTPISCLRCISACCHLLLRHTALNRDAIDFPDVILCNGPATATILIFTSLLLRFFNVRGCSSRRKMRTVYIESWARVKRLSLSGRLLKHVVDRFIVQWPQLQQAAGGRAEYVGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAW7</accession>
    <name>A0A6A7CAW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAW7"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28837" checksum="7949177563B3A2D4" modified="2020-06-17" version="1">MTQAPRKGVDMISRGVKQRTMSGIATFVTLRLADPFIQYALLYGPSRSVEDNSDFEPKERTSLITGRSILLAMSVISMLKQNYHMLFVMQEDMTPRAAAIIGAVNFLLNSMNSLLFLRKSRKHSIWLALGSKLVPVRVALGSILFAVGIVFEWLSEVQRAAWKAKTENRGQVYARGLFSLSRHINYFGYTLWRSGYTLAGGGGLWSAIVAGFFVYDFNWRGIPILQRYMKEKYGEKSNWHKQVVPYKFVPFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBU4</accession>
    <name>A0A6A7CBU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_208573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBU4"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12759" checksum="124FD9CF67A31FF6" modified="2020-06-17" version="1">MLNSFSAGGETSKPSLPALIEKPLPMKLNASVGRTVYVRPDKSMDLARSFRALEVKCAQNKVRKEARTQKFHERPGLKRKRLKSERWRARFKENFRSTVQMVQKLRGQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCL2</accession>
    <name>A0A6A7CCL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_254502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCL2"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="186"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="834"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="998" mass="112053" checksum="2A0747FB4C3BCA40" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CD87</accession>
    <name>A0A6A7CD87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_208590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CD87"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
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        <source>
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    <sequence length="445" mass="50679" checksum="AB0373401B6F6109" modified="2020-06-17" version="1">MGVSKYTDYSRESLIQRINELESQVQSPSKSQPPRSVSPKQKIRKPFNRAKYNTRHIALKFAYLGQNYCGLEHHANNPTPLPTIEEVLWKALIKTRLIFPEGDDSKVNWEGTEYTKCGRTDRGVSAFGQVIGLRVRSNRPKDHTDSGTDWREIDYIHTINRVLPSDIRALAWCPNPPTNGDEPFSARFACRERQYRYFFTNPPYAGSEPLDIEAMRLAAEKLVGEHDFRNFCKVDPSKQITNFRRNIFCAEIHTLHSAVGGEQIFYFKVHGSAFLWHQVRHLVAILFLVGQGRESPDVVDSLLDTERCPGKPIYEMADDMPLVLWDCVFRTGSQPNGDTTHADGIEWVTQTGAEPYSTHGVLTELWALWQRRKIDELLAHSLMRLVEGELVASPANDEGSDRVFDGSERPQTVGKYVPIMQRARTEAPETVNARYAQRKGLHHGS</sequence>
</entry>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="685" mass="77430" checksum="9F30E5B86D6EE083" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
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    <accession>A0A6A7BPC8</accession>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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        <source>
            <dbReference type="EMBL" id="KAF2857226.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000799421"/>
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    <sequence length="211" mass="24509" checksum="06AAC4DC8E31B419" modified="2020-06-17" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILMPNLYQNPSWDAKLRGQMTASQVQNHFDAFYEDLWCEMCKYGEIEEIVVCDNNNDHLIGNVYARFKYEECAQAACYALNARWYAARPVYCELSPVTDFREACCRLNSGDGCVRGGFCNFIHRKEPSPELERELQLSTKKWLKLRGRDERSMSRSPSPPPRRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPF5</accession>
    <name>A0A6A7BPF5_9PEZI</name>
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    <reference evidence="3" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006069">
        <property type="protein sequence ID" value="KAF2857092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPF5"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="50267" checksum="CEEA5961D0D84AAC" modified="2020-06-17" version="1" fragment="single">RKKRSDKVIVTPRRRVLAVSSPSPSRLIKTPVTSSRRTAAVYHQARQLFSRCSTGCLFGRDEERSQLSTFLDSALSSKSGGCLYISGPPGTGKSALVNETIETYKARVSLTIINCMSVHSAKELEQKLTFDLEIANFKKAFTSTKKYLVILDEVDHLISFDQELLYRLFEWSLSPKSGLILLSIANALDLTDRFLPRLKSRNLRPQLLPVMPYTAPQIASILTSKLSTLSPNQDLPFFHPAAITFCAKKVSSQTGDLRKAFDICKRAVDLVEQEAAQAELEASPTKPLSENTNLARLSPTTAPKVTIAHVARVTAQVLSNNSIQRLAALNLQQKAVLCALVKGEGGGTVVLKGPSTPKKSDSRAPTVAKLYATYCGLCREERLLQPLTSSEFGEVVSSLEGLGLVEFGEGYGPITPSRTPGRVASPRKWVLEEKRVSSAVGIRELRDAVTGPGAEVLRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPS4</accession>
    <name>A0A6A7BPS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_260921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006049">
        <property type="protein sequence ID" value="KAF2857340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPS4"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="284" mass="30668" checksum="1E883BC049C125ED" modified="2020-06-17" version="1">MAATQKDKSQLSLARQLSNIPWCEQYERMISGMLYDAFTPELEAARFRARKICHEYNTTFPSFPTGREGGEHETNPVPSEGSSLKVGSSAVKPEAQSQTMEQTPKTLTAEGNSSERQKENKSEGVSQGEESMSVLAANRFKILSSLLGFCGSGTFIEPPLQVDYGSNISLGLSFYSNFNLTILDCALVTIGDRVMFGPNVSIYAATHETDVTSRREGVEYAKSVSIGDDCWIGGSVTILGGVKVGRGSTVAAGSLVNKDVPEWSVVMGVPARVVRRVEPVPPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQD8</accession>
    <name>A0A6A7BQD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_279270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQD8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="146" mass="16880" checksum="9B301FB994177F4D" modified="2020-06-17" version="1">MDHPANKAIHLKNDIPTPAITLAENWPIVRSYAWALSFCSHNIISPPPSTRMAYKGIEEVMRMKPKPLQERRLVPVSRVFDCILCNNEKCVVVKRNKKKRTGSLKCDECGRTYRVELKAGYTIKTADVFRYWIHAIHEMKKKEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRV0</accession>
    <name>A0A6A7BRV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_148136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRV0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="78" mass="8618" checksum="CDF519F4DD8C1F2E" modified="2020-06-17" version="1">MCIWMFSIQRLPCMPSVECLQANPSTLSRSLLAALGTQTFRQSTVQKCCTFRALEIEPTGTVVNRSREARGNPSGKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS07</accession>
    <name>A0A6A7BS07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_272829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS07"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="203"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="335" mass="36315" checksum="68F4BE751D622FEC" modified="2020-06-17" version="1">MSQTKSTDVWIAGATAAFTVDLIVYPLDTIKTRLQSPDYAKRFRGSGGINRSLFHGVYQGVGSAIIATLPSSGAFFTTYETIQSRLEKLNARVSNRIPQPLIYSLASGCAELVSCAILTPAEVIKQNAQMVDNSNSNRPKTNATLATLKKFRSNPAGLWRGYAALAGRNLPFTALQFPLYERLKAAIKRYRYERGLRTNTITEAGLITAFSAGAGGAIAALITTPVDVIKTRIMLAAADESVSSKPSKRLLKDATGAAVDAARKPGQAVRNMVQRKGMLQVAREVMQEMGFRGLFRGGPLRAIWTLVGSGLYLGVYESGKMYLAQRRPDVADEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS45</accession>
    <name>A0A6A7BS45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_273215</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS45"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
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    <sequence length="635" mass="71450" checksum="36C1263B43E0C9D0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSB4</accession>
    <name>A0A6A7BSB4_9PEZI</name>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14414" checksum="AB484B2811B6B91A" modified="2020-06-17" version="1">MKPPTRIRIIRPTIRRHAREDCERHLASAARKLALGSERVDSTFECRSSMTSAPESTRGVPLHHQSDHGEQSFLEVRVPNRWANMAITISQALSIRTLVKLSATPLYHPLTNYNSQANPRAITRYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTC4</accession>
    <name>A0A6A7BTC4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="68" mass="8173" checksum="FE5A4CA29F1045EB" modified="2020-06-17" version="1">MSYVSRKNCFQLYHWMILYHCHCAQGWVHLLPYGAPSLKPRQNHTPFRTYITHHNATQTRNETNNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTH2</accession>
    <name>A0A6A7BTH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome subunit P45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_259885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="391" mass="43700" checksum="030DA04CE5926FB3" modified="2020-06-17" version="1">MSSDPEREHALSEYKTKLLESREFEAKLKALRSDIKALQHKFDVSEENIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKTKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNEQIRELREVIELPLKNPELFQRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEAGRLEVLKIHAAGLQKEGDIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAVNQDDFNKAIRKVAEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTJ6</accession>
    <name>A0A6A7BTJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PLU-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_278413</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTT4</accession>
    <name>A0A6A7BTT4_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_222408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
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        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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        </subcellularLocation>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUB1</accession>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUB1"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="368"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="485" mass="53402" checksum="7878169753559FBD" modified="2020-06-17" version="1">MLALPKNALRPTATGKTVRSMATVLETPPVHRHGGLRDQDRIFTNLYGRHGADLKTAQKNGDWYKTKEIILKGHDWLISEIKSSGLRGRGGAGFPSGMKWSFMNFKDWEKDTKPRYVVVNADEGEPGTCKDREIMRKDPHKLIEGCLVAGRAMNCTAAYIYIRGEFYHEAAVLQRAIQEAYQAGLIGKNACGSGYDFDVFVHRGMGAYVCGEETSLIESLEGKQGKPRLKPPFPASVGLFGCPSTVTNVETVAVAPTIIRRGAKWFSSFGRERNSGTKLFCISGHVNNPCTVEEEMSIPLRELIDRHCGGVIGGWDRLKAVIPGGSSTPMLPKRLCEDQLMDFDALKDSQSGLGTAAVIVMDESTDIVRAISRLAKFYHHESCGQCTPCREGSKWTDQIMKRFEAGTARSREIDMMQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIAENAKKSGGEALAGGWDHDAVKKGMLIAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUC2</accession>
    <name>A0A6A7BUC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUC2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="745" mass="81309" checksum="92C1B0EE5F8E0E36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUE2</accession>
    <name>A0A6A7BUE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_220214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUE2"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31986" checksum="0C37E2CCEE3E1A14" modified="2020-06-17" version="1">MRTWLKGPGKAFRDPLPGSTNYLGAYDKSGKLIRTKQQAEDGKLPAERRSDLRPYPQNPYFRSEPVLSEEFRELIYDLVVNHKHDIVSLAAGFSIDTRRVAAVARLKAVEKQWEAQNKPLATAYAEAVLAMLPQTYSKSQTPHESVNDLPVHRATNRQIFYPTSESRQFTREDAAKAFSEDLLPAEKRIPIPQLVQNQRWTDQGKTREERELLQRQADAAEAAEAAAQERKRREDAAARIRVVQGRRWDFVFENVTGAGHRYGFPHEDRKRGHVKIPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV47</accession>
    <name>A0A6A7BV47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_300791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV47"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="23996" checksum="87798FC3CD11AF26" modified="2020-06-17" version="1">MPTQRGYLIAFEGLDRSGKSTQCSRVAARIRSAGQEVKIISFPERTTPIGKLIDEYLTSKEDLHPRVLQLLFTANRWEMADKIVKLIEEGTTVILDRYYYSGCAYAAAQGLGLAASRHAEVGLPRPDVCVFLDLGAEEAARRKGFGFERFERDIFQEQVRIQFDELRRHEDEGEDMVIVEAGGTVEDVDESVGAVIARAAERSGSGPLRFVQPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVD2</accession>
    <name>A0A6A7BVD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_265655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVD2"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="471" mass="54219" checksum="0FDFD178193EB560" modified="2020-06-17" version="1">MSEDSAPEHAVETEATAQASVKTIAVRPSTPEPSPSNEKSETEAETPQIAPAASVDTLIKRRSRVLSTAEEKEEEKLRSVALLKCEGNPTGFGTSSIAPQYADLDKPWRCGNPMCSTGMTYHSHRKYQRNPANRYFGGSRFEANMVPGKVRHTFCRKCYQHAERPGKVKSREPEAKRQEAFKLAEYYIEGQLLRYATWRPQAKFKIRMNKSINDRYREYQRCLARHNNDHEAAIADYSKPGSKYADRRRTNLKKQKRNLTNDEAFPLNYMEEFKEKFCTEDPVDYEIIMNTLEKIRNLFEKGVIPQMPPVWFIMGDVQIDEQLNDEDGNYRAWMTHYYNNLEPAAQEDEVQSTNAAKARGENEKEKREEDVEREENKDEEEAEEEAEEQRHKDFDIEMESDNPDKATGSKPVTGRKRKHTDSEKLHKQAATGDSEVPTTAPGSKRKHKGSEEESMGESTRKPKGTNKRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVG4</accession>
    <name>A0A6A7BVG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVG4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="85" mass="9115" checksum="F069E4716492E9A6" modified="2020-06-17" version="1">MASSAGSFPLILSPGFRASLLPRRCKCFFVVHLLDLLRCGWMNFALSLNYNGGRQRVLDSSIAASAYAGHLHSKSAIPPTLPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVP8</accession>
    <name>A0A6A7BVP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_265292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVP8"/>
    <dbReference type="OrthoDB" id="5393981at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17542" checksum="4D83F7A681CA8EA6" modified="2020-06-17" version="1">MGQHVAKVKRIFPFVLDHRNREPMWIFDNVTNHTGLAKDALAVDKMNLGPRRKQPVMSDGWKPVTHAPHPGPVATATVMNILPSDFIAVPNVVQGLIKVLTAWHLYAVSRVTKLFDLSSIKYRCRYKGFPDIARCIVLYRPSYPTRLWQISPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT7</accession>
    <name>A0A6A7BVT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_271641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVT7"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="209"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="463" mass="48937" checksum="6AAA59CF5C253D9C" modified="2020-06-17" version="1">MTQPKVLFTVPNIRGYHLQNGSESCITPSGAQTLSLLMVPTGTAEGEEDFYLHLNLPPELDLPLPATTQIYHQPPNSYLIPRWDMEQGAFTRIQFPPVGKGVTQDEVDTFETILAQCTAFMEKAKPPTGKSHETPGKGRPGQIVLIDEDDGSVVGELGENATIVEDPRLHAGSKTPVEVEVSPDGKQIHVAPASEEYLRMANHPAYKNSTIVKEAAAASRLIVTGSSKLGQILTSGAESFTQKTKPAKPLEFTPATHDRVRKINNLTQNAAGLSSRTVGQAAQLAQNAAARFTGRTKVRPHKGFDEKNQPLPADEYKPGLLNKSMIAFSTIADGIAYGGKSLLTTSGQAATTVVGHRWGSEAGSLAADLAGGIKNVGLVYIDVTGVSRRAVIKSVAKGMVVGRVRGGGEVVVGGGDGGVIPDEDRRRMEQTKAGASGAPSGGYAPTTGEYRPVGGAPPKYSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW09</accession>
    <name>A0A6A7BW09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_218854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW09"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="242" mass="27142" checksum="2E9634AEE5DD90D2" modified="2020-06-17" version="1">MPHPEAQESLLPTTHTRTTIPHHLLKYWLARHTLFSRFSSGILLPDALYYGVTPESIALKISSHLSSVTSPKKRVLIDAFAGAGGNTIAFASSGRWDRIIAIEKDDVTLTCAQNNARVYRVEDRVEWVGGDCFDVVRELVGRDASREEAVVIFGSPPWGGPQYVKQKIFDLEKMEPYSLRELVEGLGGGDLVLYLPRTTDLRQIAELVPKEKKVKVVHYCMSGRSKAMCVYLGDFEYGNVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW73</accession>
    <name>A0A6A7BW73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_219672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW73"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="47755" checksum="18F0FBA7A64593A8" modified="2020-06-17" version="1" fragment="single">MSVVTGCIRTAGLFKDSGAEFDGTKIPGLVSTLAQSVLALWRDSIVVNSTVEPTQKIRTASNGLRIEVPLLQFAQSRLGVKSIDSGRDVRVLQVNRFNPKDKFMSTIIKHKGGHGYRLLVKGASDIILAMCSSTVNPTVGINPIDLTADDRKSLQDRIAGYGDSTLKTISFAFRDFETWPGEEIVTGGLTFLAVMGILNPVRGGSVTGVKDCKKLDLSVRMVTGDNIHTAKAVAKECGIYTDGKAMKGSDFYQLSRPDQLTVLPTLQVLAECRPKDKHVIVERLKELGETVAITGSDADDAIAVKSADVGYAPIWASEIVKEAADFEMRLDSFSYISRTFTSYRSLREAAPKILQFQIPNTIITATVIFVTSVANGNNSCLLTIFHVYWLTLGVGAIVAQALGKEPPLSPINFTLNKIAMWKMIIGQTIYQLTAILVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWA0</accession>
    <name>A0A6A7BWA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWA0"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="44297" checksum="320BAE2D4A5163E8" modified="2020-06-17" version="1">MSKSWAPLSQEELEKRRLVRCNKETVTDVSATDVIGHWGPGVDESWDIEKFKKNLSVVFHEKRPYNNTFSLFGVDASIANAFRRIMLAELPTVAIEIVNILDNTSVIHDEVLSHRLGLIPLTAGTEGLNWLKWYRKLPPKDDYAAQASWPYDIDLTPNPDGEPDPHNNFNTLILELNVECRWATQAQDGRDGKALARAGENDPKIRYVNSSVYAHQLKFRPQQGQEAYFSGDNVLRPVNPDILIARLSPGQRIQLQCFCIKGIGSDHAKFSPVATATYRLLPDIKITEPITGADAIKFQKCFPRGVIKLVDGPNGTKQAEVDDPMKDTVSRECLNHSEFEGKVRLGRIRDHFIFTVESTGQYTSEDLFLDSVRLLRLKAQKFTNHLDDLEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWE3</accession>
    <name>A0A6A7BWE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_265258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="374" mass="41517" checksum="BC257449BECAE4A1" modified="2020-06-17" version="1">MNLAISILIPLCVISSVYLYAYPVFNAKCAFPKAGVVRLLALADPQIEGNSAISAQRDAVSRLRKQVDLWGNDLYLAHIYRTLKRFTSPTLTVVLGDLLGSQWIDDTEFSRRSDRFWNVVFDGFSNVLTLPGNHDIGYAGDISPARIARFEAAFGPVNAMETWNETLRVVLLNSMNLDSPALNLDLQQQTWDFLNDALAPKEQESILLLTHIPLHKEDGVCPDAPFFEYFGDEEGRFASYKGGVREQNHLSKETSRAILDKLAAFESAFVVNGHDHRGCDTLHLPNGVAERFNGTIPEGGIREVTVRSMMGEFGGNAGFLSAGIEDGRWVFEYSACQLGVQHIWWAVHVLDLLTLGICIGFGAKKTLRPKAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWQ2</accession>
    <name>A0A6A7BWQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_258641</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWQ2"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="72"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2859624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="346" mass="37791" checksum="DDFE06A3805008CC" modified="2020-06-17" version="1">MESRSSDSSHSTIVLPRWQPDHEVGTCPVCGSGFGFLTRRHHCRKCGRVVCNACSLHRITIPHQYIVRPPVPAGERVERPPSSAGGETVRVCNPCVPDPWTPATPRGEGEGVRRDSSPTERAEESRQYTPTSMNSGGLAPSSSNTTRGSAPVHVPNTTAVPTPSRTSIHSRRNNNVDSSSAPISRSRLFRPSSSLPPIPQVAAGPRRALREEDECPVCGCELPAGTQEREDHIQRCIAERFASPSSASIRPNSAATQLGSTPPVGSRARATSSYHSRGMAVYRATEKDCVDADGNQQECVICFEEFQPGDELGRMECLCKFHRMCIRQWWLRKGAGSCPTHQLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWY2</accession>
    <name>A0A6A7BWY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_96362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWY2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="99" mass="11567" checksum="FC729056DE98936F" modified="2020-06-17" version="1">MPLVAFLMVTQLYYLQHTFWCPWRIFSITSGSSGSCENSSWTLECCSHQSCCILGTKRAERIDFMLYPWHMNADVEAVCTDDLGPERGEMMKFQRCWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWZ9</accession>
    <name>A0A6A7BWZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_282490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWZ9"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="266" mass="30186" checksum="D63B54C1926400E5" modified="2020-06-17" version="1">MLIIGLTGSIATGKSSVSKILSSPPYNIPVVDADKIARQVVEPGTPAYKQIVTRFGPSTPDLLLDNAHDFGQGKPLNRPALGRRVFGQGFDADRKALNGIVHPAVRKEMYRQVLAAYLKGSWAVVLDVPLLYESGWEPLCGTIIVVAVTDPQVQMRRLLERDEYLTEDDAKERVAAQWDVRDKAKRCEHRGPGRGVVLWNDGSKDELKMDVDRVVTQLKEKHPQWWTWMMLFCPPLAVARALWVYVRGSWTKRQWENEKRMEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX48</accession>
    <name>A0A6A7BX48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_90199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX48"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="16961" checksum="3A602A73D120C072" modified="2020-06-17" version="1">MLPKFFSLSTKEEGRAGHRVAGCTLPMPPRTRPRRWRHCVAIPLIVRAASIYLSEFPSVSLPAIVIGVPLRSTGLRIRLYLVVRHQALEIPFFGARRLRLQIECESVTATAGVRVRVSPVGQTPYSSAFLDASGSLIIWIARSISIRSDVGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX69</accession>
    <name>A0A6A7BX69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_271237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX69"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="138" mass="15409" checksum="F2DC7C01308A1696" modified="2020-06-17" version="1">MADRLTQLQDAIDHQLSLMYAAVNYIQGKHPPGQFPGQPSQRKDGEEAAATPGGSPHSPDEFEASLRELAISLVLQEQQIEYLISSLPGLGSSEETQERRMRELETELRVVRQERIAAERDKEIMIELLGNVITGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXB4</accession>
    <name>A0A6A7BXB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_217868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXB4"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="42"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="333" mass="37048" checksum="F1E3A02C31B716EF" modified="2020-06-17" version="1">MGDGFSLVDADRDALYNYDAAAVKELTDKAPWKSDPTHFKNVRISAVAYVKMVMHARSGRDMEVMGLMQGHVQHETFIVTDALRLPVEGTETRVNAQDEANEYLITFLDSARQAGQVENVVGWYHSHPGYGCWLSKIDIDTQVLQQYSGPMVAVVIDPHRTVSSGKVDIGAFRTYPEGHKATERYTGAATIRTDKAADFGAFAHLYYSLEVSHFKSTLESKLLQSLWNKYWVQTLSSTPLSSNRDYTTSQIQDAARKTNRATEDVKYRTKNLRSALELRENLSSRPADLEQAVKAAEKITVEDEMGLMAATTKEKIFLSSAVGGDTDTAMVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXR7</accession>
    <name>A0A6A7BXR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_248241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="2"/>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXR7"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="522" mass="58717" checksum="82F407845D0C4EC4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYD4</accession>
    <name>A0A6A7BYD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_217854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
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        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
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        <property type="reaction ID" value="UER00672"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:glycerol kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
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        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
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        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
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            <end position="473"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="528" mass="58188" checksum="5E7F978A2D2008A1" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7BYI6</accession>
    <name>A0A6A7BYI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_93097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYI6"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33437" checksum="61A32A21008B4F4D" modified="2020-06-17" version="1">MTHTVIRAVLFSLTFAATFYVLASSVYLLTFEGARIAIHAVCLIASAGLTILFILVTGVANHSGAQRSNESLVRGTRSPFLRLLAQILHCVSIVAWLATLAYAVIRPLLILHGEQHGMYLVALGCGLFCLMSTSYLLSLSQCNRTEPIKQNSSSRFLTCNNNPSEMSFKCLESTHTDRGSTYRDMPSPHIVSAPTYRESDFGDEVNLLPPPPVRAIFPPPIPKRYRSLRIPSPVSSTTLEEKRYTGMSTVSVGRTVGVYTNLHDGLGIEQPVRQPCMRKWLLMPPQPARISRSSSVYSCSTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYN9</accession>
    <name>A0A6A7BYN9_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_90663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
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        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="229"/>
            <end position="250"/>
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        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="46358" checksum="E2BB4DDABCAA6CB5" modified="2020-06-17" version="1">MAQRTAESFTTTPREDGGGSAPEKQLHTSNEKVEQILQASRIRDYARLRELAAEEGGFVDDLTRRTAWPVLLACNSDETHPDAELVPHPDEAQVDLDVDRSFVYYPEDESEKRALKRNLAGIIKKVLRRHNMLHYFQGYHDIVQVLLLVLGEDAAFEAVRRLSLLRIRDFMLPSIAGTEIHLRLLPPILHALDAELYRHLSQTQPFFALAATLTLYAHEIEEYGEIARLFDFVLANEAAVPLYLFAVIVVSRKKELMKIDANEPELLQAVLSKLPKPLDLEGLIQRTSDVFKTHPPHKLSGRAWRQVSNYSVLKTTCKPEELAQQTPEHGECLFMQQDAEIKRREARALRHRQLGLLARRYRWPATYAGLVLFPVILAYGSTRLPATFWSPMLFHMRQQISHVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX1</accession>
    <name>A0A6A7BYX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_282393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYX1"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32719" checksum="6853304EB92B10E3" modified="2020-06-17" version="1">MNTEPIRRQSIRWARRRVGNIDPLEAYGLPSRGETGLFDYKAQEKYYNEIVERYIKFYAASKGESGMVDLEQSFADMLIKDDSPKGTSKDMSVILMAMRKLREGITSSRRCDHFAQRAYVFIVHAGILARHWETYQPALNYLLNCIHPQTPLSPPELQEVVSYQALDLACRQDELMDAFAVKQAHKINDRVVNAVLISLVQDNWVRFWRLQKLVDGYQHALMEFSRERMRTHTLKCLGRSYLKADQDFVERSADASWSELVKGGVGWQLQEDKSVVIRKPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY5</accession>
    <name>A0A6A7BYY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_271319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY5"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16458" checksum="FE3B891DCC5DED69" modified="2020-06-17" version="1">MSATRQDNGGAALIKSETALAERLSHLEQMQRAEHPETMAACFDFGEFLHKTSNLGHAGLIYDRILHACGKSHPNLNPRLAPNTLNNLGNLLKSQGKIAEAERAYQRELDQHAKISTVDTEDSLRVVYTLGIYNRDVGNFAAAEFFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZR8</accession>
    <name>A0A6A7BZR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_257593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZR8"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="566" mass="64380" checksum="12ADA1C1D7157F42" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q3</accession>
    <name>A0A6A7C0Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_270623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Q3"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="363" mass="40803" checksum="7D350874D0A808B1" modified="2020-06-17" version="1">MSFKTPDTAVSEQIEFMIKPDIAEGDIGRFDDLVEVLGINSPIVATAAVYHISNNLKQNEKHKQIRLLVLLDNFLSSVGSKFPHNFSNNKLVKCLDWVASEAPDEDVRQKCQDMFARWAIAHKDSAESWRLSVRHRLVRRDERRRTRATVRRLQRESAQQEASQQRATWKETTQQEATREDATLQEAIQKDTSLKRTSTSHQGRLSTTPAHQSSQQTPSPTSPSSQREPTAPKMTKSNDLPSTQLAKPKHPAGPSQLERPNLHSQYRVFSDQTSGFANKLDAAIRSMELRQGDPAILPIVQEIKQNCNTVYEDLKREVNASKNPMEALFMREGFEKLEGAIARFDAAVELYAPDALAGQASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C144</accession>
    <name>A0A6A7C144_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_203755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C144"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11881" checksum="6C300EEEFAC7E729" modified="2020-06-17" version="1" fragment="single">RLPHSVIERRYRDNLNRQLEMLRTKLPTLKDGSTPGPSEIEDSAVPPKFPTKAVIIGAAIRYIEQLEAERDRQNSRVRSLHDQVEGLQKLVRCEDCAILKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1A2</accession>
    <name>A0A6A7C1A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_299336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1A2"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="18081" checksum="E077AB98416D4E9B" modified="2020-06-17" version="1">MHIITGTSDQNSITRDMANAKAAAMNTLYNNYGITFTLRDVSFAINDAWAAGDDSTLDTAKAALRKGTHAILNIFFHSQLAGGKMLGTCTLPSKVYAGAAASVYSNNGRNVNAHTMPGGTMSGTDGCPKDTASISCPEMSTSDNTHNYMDHSSDLGRVRDMWTQFRKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1C6</accession>
    <name>A0A6A7C1C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_62902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="95" mass="10857" checksum="A93E05600E4D8DE1" modified="2020-06-17" version="1" fragment="single">MEGYGGALFVDTGVVQKARELEQQQADAKEREEQEKAQRVRERAEAKALKAAETLRKRQERQAAKDVRMAAKVRKKAEVTARKTAAHRKDDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C2B3_9PEZI</name>
    <protein>
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            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2B3"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="231"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="385" mass="42174" checksum="091E50550E0529DD" modified="2020-06-17" version="1">MFRRRIHTVADGIITRLSAQPLHPLTLSDLCRHGRPPLSPESLLSSANFTLSILPTRLAHRISSLRNLPYIVVSNPHIHKIYQNYLHSLSTLLPFAERPILTLSEEETFTNRMSDLVETHRDTIPTLARGFRQVARYIDSASVERYLDEHLRARIGTRLVAEQQIALHRSSNEGRHASQDSFIGVIDTALRPADIIRRCETTVAEICELNYGVRPFVVLTGDLGVRMAYVPMHLEYVITELLKNAFRAVIETGKADEGVEITIAPYPISNASPGVTIRIRDKGGGISPENMDKLWSYGFTTFDEFEFAERVSGAGTGAGAGAGAGWQGVSVGGNPQGSTLAGLGYGLPLARAYAEYFGGGIAVQSLWGWGTDVYLTLRGVGGLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2H9</accession>
    <name>A0A6A7C2H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_257460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2H9"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="40078" checksum="D70F387C056BA937" modified="2020-06-17" version="1">MSDSDIEMADAGIQFSAAAKGKRSAANLPIEAEDSLPWVEKYRPSSLSHVSGHEDILATIKKFLDSNRLPHLLLYGPPGTGKTSTALALARQVYGASNMRQMVLELNASDDRGIDVVREQIRTFCSTKQIFAGKAATTAASFKLIVLDEADAMTSTAQMALRRIMEKYTANARFIIIANYTHKLSPALLSRCTRFRFSPLHEGDIRRLVDRVVVEEGVDISTEATESLVKLSKGDMRRALNVLQACHASSTPLDNPTKKDTITQETVYDCIAAPHPKDMATIASTLLATSDLAKCLSTITTLKTSHGLALADILTSLSEHLMELDVPPQTRVAWLSGLSEIEYRLSGGGSETLQTGGMVGVVRNGVSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2R8</accession>
    <name>A0A6A7C2R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_281764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2R8"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="213"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2860998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="456" mass="50538" checksum="3E48C1030B36F331" modified="2020-06-17" version="1">MTRKSVVFIHPDLGIGGAERLVIDAAVGLQSDGHKVTIFTSHCDKSHCFQEAKDGTLDVRVRGNVVLPFSGAFSILFAILRQLILTIRTCILSNEMSSLNPDVLIVDQLSACIPLFRWALPKTKVIFYGHFPDLLLAKKGQGLVKYAKQLYRLPFDALEEWSSSTADVIVVNSKFTRSVFKSTFKRMRQMNLKVIYPGVDTDYAKDSAGPIWPNKKTLLSINRFEGKKNLGLAIKAFAGLDADRSRAQLVLAGGFDPRNAENHTTHKALQSLADSLKLQHETVSGEEAAALAQRDVDVLFLLSVPDELKRRLLGEASLLIYTPENEHFGIVPLEAMLAEVPVLATNTGGPLETIYDGRNGWLRSPNRIDQWTEVMRKPLIPSSAATLQQMGIRGRERVVDEFSRTKMVARFDEVIQALCASNSPRPIIVPAWMAYVTLAVLFAVTAAAIWNMVLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2S1</accession>
    <name>A0A6A7C2S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256994</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2S1"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2861319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="619" mass="67514" checksum="691FD8C719F43F09" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2S8</accession>
    <name>A0A6A7C2S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2S8"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="436" mass="47446" checksum="40BC3772D04762FF" modified="2020-06-17" version="1">MSHLPGTGPAAIHGTPYPPHAQTLGGTPALVPDVPINAVFLGLFLLAGTLHLATLQTNHQRGRTFGVSTLMVVFCAIRVVSMSVRVIWSSFPHIVGLGIAAIALIYAGVAFPLIANLIFTLRILRAQHPHLGWSRVVSMGFNALIATIVATDLLMMIVVIYAFFTHSIGSWKAVRIIQLYGETFFAATAFLPIMTVLVSTIGRGSSRARTRRPIDRFGAGRMRHKILLVLASAILLTLGSTWRAATLWLPVHKHRWYRSKACFYIFTFAMELSVTLLWSIVRVDKQFHIPNGAQGPYSYGGGGFVYAGEGRAPNKTEMRNMAPLTHSRGPSLFSNNWGNSRTSLIRSSGVSWGGLTRDEVRPSVAEDGVHVVPYQAFDDDIANLPGGPEDAARLHAADVGITGPGGEMGWNAKTGRWALRPISQSPARPESIRYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2V1</accession>
    <name>A0A6A7C2V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_281394</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2V1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2861577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="480" mass="51956" checksum="22FCFBA36F169674" modified="2020-06-17" version="1">MRGTCIFSGSSHPRLVDSICERLACAPSKVQLKKFANGETSVEIQTSVRDRDVFIVQSGTSQINDSIMELLIMIAACKGGSSRSVTAVMPYFPYSRQSKKKTHRGAITARMIANLLDVAGVSHVITIDLHASQMQGFFKCPVDNLFAEPLLVRWIKLNVPNWSEGVVVSKNPGGTKRATSLADALKLGFGIVTTEKRRPHTSNGMNSSSLLSCSVVEKLEARASSDAAPTEQDFALGSRGRLWSTINHKSRSQIKAMASYIKGNGEADQDDGEDGPKEVVTGRLIHGHIVDDDAPSPTHSATSARCSSSDEEHVPESMMQSIVSGMSANSRVASSLKALGGTADAANSDDEEEEALKDPEMEHTVTLIGNVKDKDVFIVDDMIDQAGSWIAAAETVVKRGGAKKVYCMATHGLFGNGSLEELEECEQVTYIVVTNAFPIPEEKKRLSNKLIILPVDNLLAEAIRRNHHGESISQLAHYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3F6</accession>
    <name>A0A6A7C3F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_244819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3F6"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
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    </dbReference>
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        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00164">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="17767" checksum="2D192C10FEEC77AF" modified="2020-06-17" version="1">MASLLGALRRLTISPFPRPVPASSLRIQPFSTTSPFRATYMQVLRGCRKGQKARRPKSPAMRNRPQQKGVCLRVTIVDPKKPNSGERKVARVQLSGGKIVTAFIPGEGHNIQQHSVVLVRGGRLQDCPGVKYRCVRGAMDLGGVSNRVTSRSKYGTKKSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3H2</accession>
    <name>A0A6A7C3H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3H2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="17751" checksum="B39A38562E9BF368" modified="2020-06-17" version="1">MCFSEGVMDDLNDLLKLTSSGWQQGVQPAGIISAVALKNLLAVFMSGVFWNFAWFRTSSQSSPLGNFWCNIPMQLFNGPLAVVRLWYTGAQTSDSFSWADACGAIGCGSSVLLFAVVNVIKHYSLVPHDVFIPGLKSFALVFRFRSVVLGHIISDQASPLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3M7</accession>
    <name>A0A6A7C3M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_256404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3M7"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="884"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="942" mass="103699" checksum="64AF6FF9F43B1E99" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y3</accession>
    <name>A0A6A7C3Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_29523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Y3"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="155" mass="17294" checksum="3B957EC7443827F5" modified="2020-06-17" version="1">MSEISFPIISIPVYYVLSIVPHAVALNLSAKGNPKGRHDNRNPKSTTMQETLRQRLSARDFAAFERAESCHRNSLENMPLYVAAVLAGVLAEKKAGAGSVGLSNFCVMWHLIRLLYTANYIMTETIRWSYLRSLLYFAGTGYAFATLYKSARVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4K9</accession>
    <name>A0A6A7C4K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_212850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4K9"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="344"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1209"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141408" checksum="9ACD29A3CE1F7CF4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4N4</accession>
    <name>A0A6A7C4N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_243553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4N4"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5P6"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="437"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="700" mass="78649" checksum="54FA78C04C3B733C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5P8</accession>
    <name>A0A6A7C5P8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_19277</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="834"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1165"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="581"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2862295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1535" mass="171103" checksum="0B39E86A694014D4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T8</accession>
    <name>A0A6A7C5T8_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">K470DRAFT_269052</name>
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    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
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        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="812"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="854" mass="95025" checksum="5CE20237A7C326E1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5W5</accession>
    <name>A0A6A7C5W5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="144" mass="15274" checksum="1D5064FCC6ABA39B" modified="2020-06-17" version="1">MSPSSSQKSRSSYVWVRSGWNGGSDSESGNETTPSDSSSGTDSSSEGETADSDFDSWSEGYETGSDRTDSVSGDSEGYETGSDRTDSVSSGSDFGSGYEAWEREYSYHSSRNTEEHVYYEGGYETGSESSDSDVGSGSESDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Y2</accession>
    <name>A0A6A7C5Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_194206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Alfaro M."/>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2862702.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C710"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="11464" checksum="F4F3453DAD0D683E" modified="2020-06-17" version="1" fragment="single">LVSVYTLDGSNASDAYVTLLHRLGARTVKTLTERTTHVVFKDGPPSLLSKIKNAGREVYCVNARWVLECEERGVRVDEGGYRVEVESQSIVGKKRRRKSMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7F9</accession>
    <name>A0A6A7C7F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">K470DRAFT_255513</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7F9"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="651"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2862999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="737" mass="85377" checksum="D2175797E096C945" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7I2</accession>
    <name>A0A6A7C7I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SEC14"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
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</entry>
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            <taxon>Capnodiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="25">CBS 480.64</strain>
        </source>
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            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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        </reaction>
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            <name>[4Fe-4S] cluster</name>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
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</entry>
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</entry>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8F9"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="425" mass="46799" checksum="140AA7F9D38F5D3D" modified="2020-06-17" version="1">MVRDTELYDVLGCAPDATDEQLKKAYRKLAMKHHPDKNQHSKEAEEKFKQIGEAFSVLSDPQKRQMYDQFGKEGLEGAGGMGGGMGAEDLFSHIFGSGFGGGFGGMFGGGMRDTGPKKARPIHHVHKVSLEDIYKGKTSKLALQKSVICPKCDGRGGKEGAVKTCPGCHGQGAKTMMRQMGPMIQRFQTVCPDCQGEGETIREKDRCKHCGGKKTIIERKVLHVPVDRGVQSGTKIDLQGEGDQVPGVEPGDVQFEIEQKPHPRFQRKGDDLFYHAEIDLLTALSGGAIYIEHLDDRWLTVELEAGEVISPGEVKVIRGQGMPSYRHHDFGNMYVHFDVKFPERIQGPLDANGAPTPMTQQQIKALESVLPPRMPQNIPPPDAVTDDYPLEKMDAARDGSRATAMNDDEDEEMHHGAERVQCPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8X7</accession>
    <name>A0A6A7C8X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_209062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8X7"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="323" mass="35542" checksum="7A3F8E26FB3A7CF9" modified="2020-06-17" version="1">MLSAKKRKNLADVTAERKKIKVTKTATPAPVPLKSALKKTALETPGVRKSALKKTEVAPKKSTKASKSQETESAALVPVADDIVPVDDGSDDGGELTADQTAALLAGFSDSEDDENDGGLALEDLPQPPRIKGARKADANDDGKTPGVIYIGRIPHGFYEHQMRSYFSQFGDILHLRLARNRKTGRSQHYGFIEFASKAVAEIVAKTMDKYLLFGHILQVRTVPREQVRATMWNRAGRRMKPIPRNKMEGRRLKHGLLREGWDKRNAKEEKRRLGKAEKLKELGYEFDMPQLKKTSAIPVAVPAVKESAVPAAKESAVSVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C943</accession>
    <name>A0A6A7C943_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase 2</fullName>
            <shortName evidence="11">MAP 2</shortName>
            <shortName evidence="11">MetAP 2</shortName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_292287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C943"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="14">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="419"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2864024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="850" mass="91344" checksum="B8DE7A42D63CD10E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C980</accession>
    <name>A0A6A7C980_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1753-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_280053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7C980"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="311" mass="33746" checksum="5764835B5FF49716" modified="2020-06-17" version="1">MSQYRGYSQSFLRLTSLLTATEFILFVLAINKVTGLYGILALFTGYNLTPLQLSHYIYSLLALGAAAYLWPSLRDHGNAQGLLKCVALAWVYVLDTAINSAYTGVFGGQWFLTLARHLNDGDRLAAQGGDGFTNPEHKVGSVDILAASEGRLKGSTVIVGTHEGIRPPGGAALLQSGSLASIAVVTILWTCRIYACLVVLAYARSAVRGYLASQGGEARNPFREDCEDGRGWKGALGRMMLRFPTTGYWLGDPDGPQYEWARATNLRFNSHHQSRGLKIKVPSSYGVSERERRARSGTGPPIPLSEGKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9J2</accession>
    <name>A0A6A7C9J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hnt1 cyclin dependent kinase Kin28 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_279963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9J2"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="132" mass="14562" checksum="8060E376F2FB4A26" modified="2020-06-17" version="1">MACIFCRIIKGEIPSMKLLESERIFAFLDISPLSRGHALVIPKHHGAKLTEIPDDSLAEILPAASKIARAAGMENYNVLQNNGRIAHQEVGHVHFHVIPKPNEKEGLGIGWPAKEANTEDLKTLAEEIRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Y8</accession>
    <name>A0A6A7C9Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_1722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Y8"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47230" checksum="38AFCECD5F5FDF32" modified="2020-06-17" version="1">MNIEAPQQQQQPQLQQQHHPPPQQPPPPPQDAPQSAASTPATPNGNANGSNSGPDGENHTPIAKPVMQDFPSLDTALAYINAFSLEHGFEMVKYGGKSMNKNNEVYRMPLVCARFGKPKQHSQAGYPYPTASSSQTPGAAGTPGQPPQRKRKSTKKCNCKFSLNLCARDQNNPSTSAWTFTFGKTDEHNHSGAKDVSSLANHRRLARGDRHVGEFLRSCRAGGVDAKRARQLAIDRFCGPGSLVMPRDVYNEWAKILSLEATPGGDISHSQPVRCHCRTGCSHGKCSCAQAGVGCSRVCHSGGGCERYDASEQEDITAMEEEEEQGPLERIEGMFNTLQEMQQRTAEEFKLRLQNLTQEYEDQNARQTELMDSLRDEVLQFLRDDQNQQHQQQQQQQQGLHSIPGSFNHSHPPPGNGLIVDYEINGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA00</accession>
    <name>A0A6A7CA00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA00"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="567" mass="64687" checksum="B5C7383808F94C4E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAC5</accession>
    <name>A0A6A7CAC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rtt106-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_254354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAC5"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="398" mass="43660" checksum="40FA990191260798" modified="2020-06-17" version="1">MESYPASLQPKINEAIASHPNPAHLKALFIEIGAYIPSDNGNNGDVSSKKRKFAHADDAKAIISPVTVWQSAEAVSVVAPMRKKLQVAVVMNAAQTKREVRLHDPKNTDSESAEYILSDSEIQEIFCLPVPEKQAKQSNFVIVPTQAAERREAIVFTVADTPSKGDTAGETEATLTRTALETHLRRKVQLPSEKEFTSGSRKGEREFHIKANRGSKDGYIFLLTTGILFAYKKPVLYFPLNHIQSVGYTNVLSYTFNLVLTVLDPNGSGEDGKEIEFSMLDQSLYPAVDKYVKSHGLNDSSLAEQRKAKLYNVNNPSAGKDAAHHAEGGGEVDEDDTQTALPRTEQQIQDEEDEMEEDYEASGGESDGEGASSEEAEAMDGHDGYDDDDDDDDDADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAI5</accession>
    <name>A0A6A7CAI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_6504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAI5"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="141" mass="16186" checksum="664C187B1CC04ABD" modified="2020-06-17" version="1">MSSFALARVARTRALPVARRAFFTTSLRRTSGPEHEETFEEFSARYEKEFDQVQDVFELQRNLNNAFAYDLVPSPSVITAALRAARRVNDYPTAVRVFEAIKAKVENKTQYEQYVEELKPVREELGVNLAETLYPEGVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAJ2</accession>
    <name>A0A6A7CAJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAJ2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="12915" checksum="F73A7952C67FB477" modified="2020-06-17" version="1">MGSQQANGLRPRLTPQPLMAQTVHPHAQPAVPAATVTLAQQQNAALAHSTACIMQYVASQDLFAQLRRVHLKEPLKSGIHPQQVQLQSSALLQQGMTENYDYAVIHHGGLRHPSIRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAJ6</accession>
    <name>A0A6A7CAJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAJ6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="99" mass="11107" checksum="E9646360F23F13A5" modified="2020-06-17" version="1" fragment="single">MRATSNMSSNGCSTLFNMVMTSLSPDLRARYHEKFWAIDSLYTILRMISNDFGPDIPHQSRNLENKWASAVTPAALQQQGLEASVTEIRKIHSHLEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBD2</accession>
    <name>A0A6A7CBD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_297858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBD2"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="279"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="489"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2863868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="680" mass="74286" checksum="2EF184B8C80448BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDG5</accession>
    <name>A0A6A7CDG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_267267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7CDG5"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="50"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="24586" checksum="3AE225F958C0592B" modified="2020-06-17" version="1">MASKWTVESALNAVARRPVTKSASPVPFFHLIERLKTTPREGWRRCGVSDGESIADHMYRMSLMTMLAPPSLRSRVDVSKCVKMALVHDMAESLVGDITPVEGVPKHEKSRRETETMDYICKELLGNVDEGEQGKELRELWQEYEESETLESKFVHDVDKIELLLQMNEYEEKLDGGKDLGEFARVAERVVLPECKEWANELLAERREFWASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP33</accession>
    <name>A0A6A7BP33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_13498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006063">
        <property type="protein sequence ID" value="KAF2857146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP33"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16525" checksum="65CF301D983BBFFB" modified="2020-06-17" version="1">MLAHVPEMVRRFGPLQGTSSEIPESLNRHLRGYVRYSNHQANSFDAAGHASIGAAKIYLANRGWWCHDGTHMTQAGEKCIEALNQPRMRRLLGLPVDPAAPIHTMSIQLPPGDLPAHDGLFTKFGLAGPNTRTRHLPACMHLSSAVFDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP94</accession>
    <name>A0A6A7BP94_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_261053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006061">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP94"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="11453" checksum="57D38C5BF661DA19" modified="2020-06-17" version="1">MGEIDIIEGTNDEQFNIITLHTDTGCAVTLPAPMQGTLIRKDCCTNAVEYDGCGIKAPVSESVSETSFPTAVHDFNALGSGLYVTYWSSAGIKIYPSREKRYRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPF6</accession>
    <name>A0A6A7BPF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_297221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006055">
        <property type="protein sequence ID" value="KAF2857246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPF6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="168" mass="18494" checksum="5BD742CD45DDC0F3" modified="2020-06-17" version="1">MTVIAKACGTLTSPSLQCRWRIILPQSNIKIRPRKRRVVGADLEPQTPDPSDAVKPYYKNDPLPPPQLDPITANPPSSFSQGEATVVVADQESELAEFSEKELGDKLLFLGSDVEQSDDETENESEWGKEAEQFDAENAEVHHPQSSRGYCAPPDLMVVEPPASPSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ52</accession>
    <name>A0A6A7BQ52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_266828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006043">
        <property type="protein sequence ID" value="KAF2857431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ52"/>
    <dbReference type="OrthoDB" id="10455837at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="206" mass="23181" checksum="8DBE1C75CF2034A7" modified="2020-06-17" version="1">MVEHGAVLGGYQATAYFYPIVRITSAPWDFYCCSTECDPDSFVGTMRQITMLELIEDVRSDENRRVVYMRGHMNGLNDPITVRISVSSSDPMASIMDLKMSYQHSAISAYGAICFWPKLGGKKQYRVFKHNGGQASYPRGKTVCAVELSSLAEERPRHHTPHPSIYSAGQKGVELVSFRNVIGVPEDAFRKRYCFLENVVYAVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQA0</accession>
    <name>A0A6A7BQA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_223603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006051">
        <property type="protein sequence ID" value="KAF2857312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQA0"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="285" mass="31633" checksum="99172898958F1989" modified="2020-06-17" version="1">MESDWCESIARMYWKGVTIWERMTTLQRIGASAAVATALILGILGLVYNERIFHWLAPWAKRWRELPGGWAILWAMVFTVSFPPLIGYSTCITTAGFVFGFLKGWAIVATATVVGSTCAFAASRTVLKPVVRRWTEENRRFAALSLVLKHDGLKLLTMIRLCPLPYSLGNGAISTIPTVTWWNFALATAMSTPRLLIYTFVGGRLGDLGEKGEKMDWKSRGVSYAGVVIGLVMGTTVGYIIYQRTKARAAELEEEVLVEEGEDEFALNSENGDGDYHDSDDGWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY2</accession>
    <name>A0A6A7BRY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY2"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="567"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="764" mass="83395" checksum="A869F2DA11BA90DF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS16</accession>
    <name>A0A6A7BS16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS16"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39172" checksum="790D6BCCE155D1C4" modified="2020-06-17" version="1">MPAEVLASSPRHLQSPHPRNASVEAPVSALPPLQSPQSLNAPVQTSVSASQPLQPSQPNSTLVQASFEKAARKNPFQGERQLREDALASISSDKREFVKKHVDLNSDLDIDAAKVQALRGISSQIMNFASVFDVATNAQAEVLSLPWAGIRSVLMVAQMAHGQDESILEGIETVLDTNTLLSAYFSTYSQVGGTPTIKDNSIFELCNGLYHSIVKLYGRILEFVAQSQDICYGMPVKQAVQSLTHGVIKVFKSDHDGMLRTVEYHARAVDREVSEEQRALVKQKLNSLEKAQQEIYQRVQGVQQALDLSALQAAAGAAYDSMDNRNADENGELQLCLKDTREQIIKDILDWATTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS30</accession>
    <name>A0A6A7BS30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS30"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="95"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="557" mass="62711" checksum="CC0B64782FB457BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS86</accession>
    <name>A0A6A7BS86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_161806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006034">
        <property type="protein sequence ID" value="KAF2857625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS86"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18032" checksum="38AAEC2A9AB1A71F" modified="2020-06-17" version="1">MKFLKVGRAIISRGRYAGKKVVIIQPQDNGTKKHAFPHAIVAGIERYPQQVTRRMSKVRMAKRSKVKPFIKVINYNHMMPTRYTLELEGLKGAVTTETFTEVSQREDAKKMVKKTLEERYASGKNRWFFTPLILIVHSVASTMSNQQTCCYPTILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSQ8</accession>
    <name>A0A6A7BSQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_221654</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="INO80/SWR1_helicase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="HELICASE SRCAP"/>
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        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="686"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1241"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1432"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1493"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1517" mass="170966" checksum="391C85BE80ED6E74" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSS2</accession>
    <name>A0A6A7BSS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_278742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BSS2"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
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    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
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    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="328" mass="33989" checksum="4697A4A30D18AFA0" modified="2020-06-17" version="1">MAHSLRQLSRGVAAARSYSSLIPSSGYGSTAKNLRITDQTKVLFQGFTGKQGTFHAEQAIGYGTRVVGGTNPKKAGSEHLGLPVFKDVAEGVKATGADASVIFVPPPVAAGGIEEAIKAEVPLVVCITEGIPQHDMVRITDMLKTQSKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRVGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLRVFLNDPDTEGIIMIGEIGGSAEEDAADFLKAENKNNTPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKISALESAGVVVERSPAALGKTLREEFVKRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSU3</accession>
    <name>A0A6A7BSU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_278685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="2">
        <location>
            <begin position="681"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="2">
        <location>
            <begin position="850"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1599" mass="175203" checksum="44D292412BE96D68" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSV3</accession>
    <name>A0A6A7BSV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_137359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSV3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="213" mass="23262" checksum="6BC4E7E1EAD19A53" modified="2020-06-17" version="1">MRTRGTSTQGTTRPAEGVHEAHPHAKRKATSSHSCHRWPSKVYRSVSVTAGLAHRWTAPPPQRHKRNTNSCQLLGKFYATTRGGRRAVSRTDFLKVIGRCVYGPKHEPMCVQKNPVGWMMVVGPSVCYTGQPMGPTSGHVRPHLATRRGHAESDHANDVIRGTGSEGRLVKVSSWWHVPAHIRSAPGPKNTHLAIRPATVDYSSSAKAATCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT09</accession>
    <name>A0A6A7BT09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT09"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="346" mass="40113" checksum="F3B27FE330FDEA68" modified="2020-06-17" version="1">MASVRNSIQNLLNSTDEVPYHQRRITINGREYMRAFYHRLYPFPCDKEELERLDMFGTILYYIVLSDDPERVAKASFAPLGSRERARVLDVGCGTGWWILLLAENRPRYEYVGIDLAQIQPGQPANKADDLHPNVRIDFDAPVDMNSGSWGRFCPPNSFDLVHAAQLLGSVHDWSRFYRTVYEYVKPGGWAEFVEIDWTPRYDGLCNEDDRRALEKWWNDLVLASQTMGRSIQLPLRVEQLITRAGFVNIRHEMRAMNCGRKAARFYADERERWRADACYRGVTGSMGCKDLRPWSGLSMELLTRFGGYTRAEVEALDARLCDAILRPENPFYFNIHVWTAGKPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT17</accession>
    <name>A0A6A7BT17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_278626</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT17"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="411" mass="45259" checksum="5E9EFBB713DA7AE3" modified="2020-06-17" version="1">MPEKGIRYAAKVDLTKDAATLPYLHNRWHPDIPCYGTIKNGESVKIECIDWTGGQIKNNDSANDIRDVDLTKIHYLTGPFEIETAEPGDVLVVDIVDIQPLEDSPWGYCDIFAKENGGGFLDEFYPKAAKAIWDFEGIYCSSRHIPGVRFPGLIHPGILGCAPSPEILNTWNEREGKLISEHTHSNRVVAQPPCPQNTHAGTADPSTKTKVSNEGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVAGAKFSVGDLHFSQGDGEISFCGAIEMAGCITIKFSVMKDGMKNLDMKSPIYIPGPVEPQFGPGRYIYFEGFSVDENGKQHHLDATVAYRQTCLRVVEYLRRFGYNDYQIYLLLSCAPIQGHIAGIVDVPNVCTTIGVPMDIFEFDISPDGLAKKRNLGKCAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUI6</accession>
    <name>A0A6A7BUI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_296573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUI6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="273"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="485"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="558" mass="62171" checksum="7D095BD9F69EEE0F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUT8</accession>
    <name>A0A6A7BUT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_250742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUT8"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="122"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="405" mass="46532" checksum="A8C62347778A5C34" modified="2020-06-17" version="1">MASQLSKKRAAEPSIEAQERPAKRGKSRKYHQRPAWARLAKTNPKYRPGINGDTAASEESPQMPPPRQRDRLSNGPNVHPMPGRYHPDQPWLDNPPLDWDIIHARQIFGNWEKSIKWNTAYPDLDREVTDWLSFHLSNFNGIGYDPTQGAIEIEAKLGHLIDRGTNERIQFPVRNMTVLEQMWFESDRFECRLTESQHAFEAGNAFLNQMTRESHTEGRVPLEYSHPRSQDVFHPLSARGRELLPAAFRNLNLHGRDLNLRTTTDVKTGIVTARIVKINLAHMHIYSPHSNYDARISINLEVDLNRPELEPFTDLVEAPSAERPAQPARNKDRCSYKHLAYQIDLTRVDVANTTPKYELEVEVEAAVLREQIRMRTFRGYNAVISGFLENIVHLMRLRGVDGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV32</accession>
    <name>A0A6A7BV32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_135258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV32"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="60" mass="6413" checksum="ABCB8CE8B4CBC54A" modified="2020-06-17" version="1">MNESSCIMPSATPAAMSQLIGLHGPIQPILHAGIVLCRYLRSSLSHSVVLPCLREILQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV51</accession>
    <name>A0A6A7BV51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_251428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="538" mass="62361" checksum="309FDF49AF760F62" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV66</accession>
    <name>A0A6A7BV66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_278359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV66"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="34552" checksum="7B66ECCF11C08662" modified="2020-06-17" version="1">MPPHKTHAHTHKLLLMNKLLSDPSPFTLILDTLEQSSRPLIKEILRRANERKMRVIFVSFEILTPPSGGNITPIHAWKEPHTWHTQTKDQLTKHSSQKTLLIIDSLHQIHDPVRTLTPFLYPNTSLIGVYHTDIPTPSVPYHPDGLTMLKFLATTIFSVRNFRSVMAFHEARGRRVVPSSFGIEEGEGVLLSRGANGMEYVLEVESRRKSGREVVEVFWMGRGGEVEVLDKILGVRGKEEEKEEVKEDGLTFELGLKEKEKREREGVVLPYYDAQATMGEGRGGRILYDFGVEDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVN2</accession>
    <name>A0A6A7BVN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_282756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVN2"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25384" checksum="30C58661ACBAB99A" modified="2020-06-17" version="1">MDAARRFFYGPTPEEQKRKCNALVRANTRRLDRDMANLKALEQKTKTLILQASRRAQREPARSEQALAETRIFAKELISVRKQEQRVATSKATLASVGMQINEAFAVRKIEGNIKSSTRIMKDVNTLVRLPELTGTMRELSQELVKAGIVEEMVSDSLDMEDALDDEEETEAEVDKILGEVLRNRVQAPTVQVPIKPLEPEVEDGDLDSEHLLAQMRGRLEGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVP4</accession>
    <name>A0A6A7BVP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_259219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVP4"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128474" checksum="F4D201F745669066" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW49</accession>
    <name>A0A6A7BW49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_271672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bet3"/>
    </dbReference>
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        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="22248" checksum="A982155AB23B99C2" modified="2020-06-17" version="1">MASSKAARMGENVWKNHMEKINAEVVTLTYGTIVAQLCRDLTLPNTAAETDYAAVNAELDRMGYQIGLRLIEDFLAKSSIGACTTFRETAEIISKVGFKAFLNITPEVRNWDKEGRSFHLSFDENPLADFVELPDDGRAQDELWYSNILCGVIRGALEMVQMQVDTRFVSDVLRGHDATEMRVALVRIIEDELPVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="513" mass="58124" checksum="04BEA4A2F2D2AEE7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWM5</accession>
    <name>A0A6A7BWM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
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            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="204" mass="21591" checksum="1A6F302B6EC4EBB1" modified="2020-06-17" version="1">MAAAQNNATIVNYANTCRDTEKHTADVVAPEIAAGKVADDELKRQAGGMFKAALQVGTSTAEIQTMALQDSTSSSEDFATGGKRGRAAARPNDSLKRFKSYKTGPGHAGQMNPPASSQGSSPNDCSQDVFLGWLTGTSQGTAMMKTTSPAAVGRAVACVSQSTETNISRMKKYARFQLGTCSSLSSITARKCYTRSVLYRQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR4</accession>
    <name>A0A6A7BWR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWR4"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="143"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="406" mass="44253" checksum="BFCB532030FC5D2D" modified="2020-06-17" version="1" fragment="single">KKATIKAEKEDPGDVNDLPHNLGTALPDLPVKRKVEDDEDGEVKVSRRKINKSKIKEEDGDGAEVKDVKVKTPKKANYGLTPGISPYPDYARPTPEECEEVTRLLSAKHGVVNAPKAVPPPSLTVAGCGEVPSVLDALIRTRLSANTTGKNSSAAFQGLVRKFGTIPNGVGKGSVDWDAVRRAPLKDVYKAIACGGLADRKSRDIQAILQMAWDENRAAEPDGADVEHTVISLDHIHAMTTDDAINKMLTFPGIGPKTASCVALFCLQRPSFAVDTHVFRLCRYLGWVPTKPGPGQPRIDRNTAFAHCDARVPDRLKYPLHQLFIKHGKECGRCRAITGTGSKDWDNTVCPIEHLVHRHGARKGGKKERKLEMMEEGMPEATADQVAEEEVAAAKTNSDSELTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX10</accession>
    <name>A0A6A7BX10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_295467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX10"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16929" checksum="5B176392F743DF97" modified="2020-06-17" version="1">MAEQTFIAVKPDGVQRGIVGDIISRFEKKGYKLVAIKMVVPTKEHLEKHYADLSDKPFFKGLVEYMSSGPVCAMVWEGREVVKVGRLILGATNPLQSAPGTIRFDYAIDVGRNVCHGSDGVESAKKEIDLWFDKEVQSWKQADHEWIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX99</accession>
    <name>A0A6A7BX99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_271656</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX99"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="66738" checksum="61AC1CBB8399DDB6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY71</accession>
    <name>A0A6A7BY71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_200533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY71"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18443" checksum="C884D52185673AA4" modified="2020-06-17" version="1" fragment="single">GLKDISSLASWTVSSAKPGNGVAALRSPDLTTFWQSDGPQPHYINIHFFKLVSIAAIRLYLDSERDESYTPTKIQFLAGMAPNDLQQFSEMDLENPMGWKQVDFSGVGPVPDDMDDDDDDDDADEEDETDWCKQPILKAFVVQVRILENHQNGKDTHLRALQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYP4</accession>
    <name>A0A6A7BYP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_258187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYP4"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="403" mass="44617" checksum="1351A231EBC97027" modified="2020-06-17" version="1">MPRPHHHRPAQIHHTMPHRVLLTSYGERSEQANLPPLAAYLLRLMQLKRTNLCVSADVNTSAELLRLAEEVGDHICVLKTHADIVDDFSDKTIRALEEISSRKQFLLFEDRKFMDIGNTVQQQYCRGPLAVARWASITNAALFSGPAIVPALAEAAQRAMAANNYSVQTNISAAPAPDWGRDEDEGEEEQDESGGGKSDGRESENDEEEIELDEDGLPKTSMSGRKPSVVSISTTICTKTEIIASRLAMRRSTSRHSSTEEEFHNDDRAEQLAELGAPPCFRSLLLLAQMSSADNMFSPEYTQKCVEQARRNRDFVIGFIAQHSLNSEQDDRFITLTPGVQLSAAGDAHGQQYNTPDKVVCEGGSDIIIVGRGILKTDDRAQAAATYRAKGWDAYEKRLRGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ45</accession>
    <name>A0A6A7BZ45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_247499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ45"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="121"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="223"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="622" mass="69830" checksum="76271AA2B7EA0FF2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZF7</accession>
    <name>A0A6A7BZF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_71657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14146" checksum="B00E5734741D9702" modified="2020-06-17" version="1">MKSFRTIEASPFFCFCHGPSHSAHSVGQNEYPAVLLQHIRLDGSDGVNMDLIERCRWNWAWLSGNDSLSLAQMLRRDCVCAGPPASPKRRGNLLHRRALLVIHSYARYHARMHGASGLVYSILASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP5</accession>
    <name>A0A6A7BZP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-Ala-His dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_282041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZP5"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="788" mass="86686" checksum="41B60B6421AAFC25" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZR9</accession>
    <name>A0A6A7BZR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_257913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZR9"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="22135" checksum="51494AC296D6AAA7" modified="2020-06-17" version="1">MVLFDDDPANLMLETKNQFLIEPDKEAQARTHTVLQALQQTRQQSLQEQQHLLKTLSRRLNKLQSQQSFEEERHDAAKHASEVLKLDTEKFRMAKGVSEAEVEGERLSSEIARLQAILERFSRGGIDLDGGQGAGGDNEVVLKLQFYRSLGIDISQDADTGEVNRAIIRNADRDDVDVITIDGSDFDTDRFWSSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZT7</accession>
    <name>A0A6A7BZT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_282210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZT7"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="253" mass="28681" checksum="4C045C30341FAC3E" modified="2020-06-17" version="1">MAEGDNKVHVTLHWLDQSRSQRLVWLLQECKGISWDVSVYKRQPDRLAPPSLKKVHPLGKSPVITVSSGKDETVIAESGAITEFLCEYYAPHLIPKRYEEGRDGDPCGETESWRRYRFYMHYAEGSLMTLLILSMFMNILSGPNVPFLVRPVARTLTGRVESSYLNPNFETHWLFLNSQLASSPGGGLFLCGPELTAADIMMSFPIIISEDKIDKAKYPKLAAYADMLKNHIRYRQSVEEMENRTGQPLKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZV6</accession>
    <name>A0A6A7BZV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53277" checksum="FC10012E19001B2F" modified="2020-06-17" version="1" fragment="single">SKMSHSPLTDLPTELLRHVIAQLPHAQAVASLSAVNHGLHWYIEEDGWRIFVQNRFPSLWPPSATSYRDVARTCTTWSKAWDRRSLVARCIQPEGDIWSLPAAEVLRMWKRPRGQTIGFTPQLDVYESVGETWVQREEVLAYSAGAEVCVRRKKGRDAKWLAYRPLKAIEGHEDVTSLHLVRPREGESGQTIVVGTANGDLRIVCLPTESCAEVKTRYCATQGQPVRSGSLLQQDDVNLVAANLGDRRISLFQIDDGGPKICPSSSIDIEPTASRQRIWSTHFLSSKHVAAGVGLSDAPILIYNLTPSGLEREPARKFQLQNTQEEAARCGPEARSSIYPIVPLPSGNGTFLSGAHDGIVRLHDLRSNRNVERTFVDSTDVSAVYSLLAQGHERILAGGSRHCLLKVFDLRMGAKAYSYCETPPKSQDWNLFLQMPVRSRSRTRRNRESPVYSLASAAAYNPHIYAGVEDTVIDVAFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="28"/>
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        </location>
    </feature>
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            <begin position="55"/>
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        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="395" mass="44427" checksum="78E57EAE18EC8C07" modified="2020-06-17" version="1">MLPVLIPRQIATRTIVHNTFAHTISSEGRQRRPQPESEGKEHTEGFNIPQQLFPKAKECNRNNQDPHGRGQDAPPESKKKPWISPPINPKLQQPSTESSPSVLVLLGASTNLTADDFRRLMPQGRHIENWKLPHGHITQIVPGRDMVTLEQLNFYFLIFASQHSAFTYQGHVTNIFKVVSSQTPSSVTSPLPPPRGYIINKIDAHAAMAAFTLVPPPQKMQLRQLRPPHSPIIDLIIKHGGYPALVNRRGRTAHEARLTLEGAQLTLATVRQILLTSAQSLGLSWNDEAEIVPRISKWEPQFNMSPLSRSQEAYDLAAKLDATSDTPKQDKAENSPKPNIRSAARIVYILGFETQGALQRFIAFWHRRHMCWEGVERKGIIEGDEPPIANVEHLW</sequence>
</entry>
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    </gene>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10785" checksum="A68D2E56A890381E" modified="2020-06-17" version="1">MSAFPSGASGSASVTMTSHVSKARQLSHLQAQLAQLTANMSDLENLVRMTSVQAESMRALGGYVGALFMASSKVLGEDTMGSNNANSSNVRAEKDSDDDNDGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0B8_9PEZI</name>
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            <fullName evidence="3">FAR1 domain-containing protein</fullName>
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    </gene>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18504" checksum="A0FCD300ACAA416C" modified="2020-06-17" version="1">MTNPNSRIKGTLPPNYEVRFVEGYYHNLTDALTAPEDTQYGASYSITKAAYTRRKKSGEVYDPEGEIFRYDFKCTCRGSSAINGQPMQRKRSTQGVSCWHHVKVVHRKEVDLWRLEFICNLHCHRVALDKLGDPAYRRFWRRRYPGVAETQVERLSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <end position="23"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="241" mass="27547" checksum="9889DE9C50B577F7" modified="2020-06-17" version="1">MFEVNPPEAFDEPTNFEPGGDPMEINEATIETVVPEFGSSIPERLSSSAVSSTNDFEFPERPIAPVTKSFFENWSQQRRFDSPAAPSRTTISPRNPEANRRKKCCLQPQTYHLVLLNLWIPEDQSWFLESSLNRRYFFDERPAGAPRRSEQEKKPSAAAQEQDRLKTEGNLDSHGNIRELGRKHRHAGVTSRVVHTALRSSLRHVELKGPKTFKETQNSPQSELWMEAMRAEVSSLKKHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Z2</accession>
    <name>A0A6A7C0Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_257445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Z2"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="245"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="375" mass="40678" checksum="D59A0FCAE0A9DF25" modified="2020-06-17" version="1">MEKKILIILTGGTICMKPSHSGYIPSSGFLEEGVSPKTSLNDGTQKIPLPAYPETPANEAITLPSLRTPKSRHGRHVRYCVLEFSTILDSSSINQTTWSLLATTISKNHPLFDGFIILHGTDTLAYTSSALSYLLTNLDKTVILTGSQTPIFELRSDGESNLLDSLMIAGHYTIPEVCLFFNRKLYRGNRCTKVSVNGYEAFASPNFPPLAVCQTDRIEVNWDLVLRNRDPEALRVEKPLEMGGIDILGVFPGMTAQRVGRGLSDEGLRGIVVLTFGAGNVPSSEGNSILGPLKEAAERGVVIVSVTQCLVGSVTPRYAPAAALEKMGVVPGWDLTLEATVTKLAFLFAQGRGQEEVKRLMTVPVRGEMTVKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C102</accession>
    <name>A0A6A7C102_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_264418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="954"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1718" mass="189148" checksum="E0DBD4CE28F119B5" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7C1B3</accession>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>L-ascorbate</name>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
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    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
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        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="209" mass="23291" checksum="3EEA0367CF68662A" modified="2020-06-17" version="1">MLSCGYSEAGLTSPISEESFKPATIHNADEEVFDPSVRNSFIAPLSQLARQDSIVGKTVQCLESRALSFQGWPAHSYIEPLYTQKYVPGGHYSLHYDWGSANKNARRESTFMVYVSASGDGGFEGGGTWFPRLSSPVSEECGNDSQWCEYIECGGQREGVTFRPKAGRAVFWRNFDANGMGYKELIHAGLEVKKGVKVGLNIWTWYYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1E6</accession>
    <name>A0A6A7C1E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="122"/>
        </location>
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        <location>
            <begin position="183"/>
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        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="23616" checksum="9A388ADFA8517EBA" modified="2020-06-17" version="1">MDENSVQTIGGNNYLPIIPITREWHPQISTKGRDHMPRAEFYIVIAISPLCRTCGAPACLRGLQYRLPQRYMLIQVGRSLGRVDGPLASRVGGSPSRVDNSTSRVGNTSTTRPYRIVNTTNPSPRGVNKLSISIYDRVDQFLRASGRVDNPSLRTDNPPTQGNALCLKPNTLSLKPTIHSFEFKPTAPSIKQKNQPSPTHPSKPLTTSTLTTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T5</accession>
    <name>A0A6A7C1T5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Ras guanyl-nucleotide exchange factor RasGEF</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="21"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11727" checksum="C648254004CFFE6F" modified="2020-06-17" version="1">MEARSLYRQFLREMPARKPSLLANPSSLQQRLRAEFTSRTPSDQSSSSSSELAKTRQFLQYLRAQRQYITLLERYNPGMNMDEEDRVRMTARRVGLDVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T9</accession>
    <name>A0A6A7C1T9_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
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    </protein>
    <gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <source>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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        </source>
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            <dbReference type="EMBL" id="KAF2861540.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="450" mass="51024" checksum="B987F74CDE7973C5" modified="2020-06-17" version="1">MTEPTRSLRRGLPDEGMRQPKETMDFIPNGIIGQINKEDWPIFGGYKVCRDLDLVGESAQRPEEDGAIDGIRDRKDVDVFGSVGGIADLLCKCPAYALAAMLESNKVRAPFPTNDVKSKQQWNTRLNIVLVQNEDSVRNKISRMLLPEPVVVIPNYNETQGPISYVSSQGWVVKIRSLPKKPKHDVPYGMSWYAFNEAHRTRLKPYTRYRPADFTKSWHCFPLLVDKIKGASGKNTTCRNQANATASTAVEAIVHLCEYIRPDGLAALEGKLLCFGVQQNHQVVEIFRHLFFRKGDRSFYYMISLYKFLLSDDIIERADVDGRVQCCSRTLAITHASQEHHYPRHEKLILGLVNDLMSIPTERDKEDAPEAAPTARTQSKRPASASTIGTVFVESQKLTLQTIGWRFGIKEQIFSRMMLGPAIKSQVSSRSGSTSWKRKSRKWRKDMMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2F9</accession>
    <name>A0A6A7C2F9_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
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    </dbReference>
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        </location>
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        </location>
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        </location>
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            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="KAF2861209.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="579" mass="65175" checksum="9C926BF66458AC05" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C386</accession>
    <name>A0A6A7C386_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="18" type="ORF">K470DRAFT_27732</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="175"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="292"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="400"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2861707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="493" mass="54157" checksum="F22A157867066C5C" modified="2020-06-17" version="1">MMEKTSTERVEKLWSNLDPKRKGSLDLTALKQGLQRVNHPLKDADAFIQEMLRACDLNNDGFVSRDEFMRFCAQAEQQLWSLFCSIDRDNSGTLDRSELKHAFHTAGIKISNARLDSLLNSIDKNNDGRIDFDEWRDYLLFIPTNSPGMAAVLNFYNNTVKFTAEGDVHLSDEALSGFGYFIAGGLSGITSRTLTAPLDRLKVYLIAQTGNAEDAIQAAKSGNAVKATAHGMATLVNACKELWAAGGIRSLFAGNGLNVVKVMPESAVKFGSYEACKRAVARFEGHSDVKNISPVSQFLAGGVAGMISQAVVYPLDTLKFRMQCETVAGGEHGNRLIVDTAKNMWNRNGALSFYRGLPMGLVGMFPYAALDLFTFESLKKTAVKRRMNKYGFDHEEDALPGNFTLALMGGLSGAFSSSIVYPINLLRTRLQTQGTASHQRTYTGIVDVTRQTIRCEGVRGLFKGLTPNLLKVVPSVSITYVVYENTKRALHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3F1</accession>
    <name>A0A6A7C3F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-coenzyme A transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_214836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3F1"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="494" mass="55017" checksum="FE94995E8F9BF9BD" modified="2020-06-17" version="1">MVPLTLDLHQRKEAQGFWSLPERDRRHFMLLVLLYFLQGIPMGLAGGSVPFLLKSHLSYGQIGVYSLASYPYSLKLLWSPIVDAVWSRRVGRRKSWILPMQTLSGLGMLWLGSRAQAMMENAGLNDGAGVWGLTRWWFALVFMCATQDIAVDGWALTLLSSENLSYASTAQTVGLTAGHFLSYTVFLALSSPHFANKYIRSQPLDSGLLTLDSYLTFWGWAYLLVTLGLALLKREEPTREKDSIAEVYKTMGGILKLPNIQIFMLIHLIAKIGFQANDAVTNLKLLDKGFSQENLALTVLIDFPFEIGLGYYAGQWSERYRPVTVWCWAFVGRLIAALFAQAVVMTFPLGGSGLLLVIIQHIFSTFTSTVMFVAISAFHAKISDPAIGGTYMTLLATVSNLGGTFPRFFILKFVDVFSIASCSLPEKGGEFSCVLETDKHRCVDAGGVCNIRRDGYYFVNIACVIFGTLTFYLFIKPAALRLQSLNMRAWRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3R0</accession>
    <name>A0A6A7C3R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_200545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3R0"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="217"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="737"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="935" mass="102565" checksum="8BF39AAC448996C9" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3S0</accession>
    <name>A0A6A7C3S0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_23665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3S0"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="44157" checksum="1F0A821731F668B3" modified="2020-06-17" version="1">MLAHRSPLPYMLLAGVLIGLTLLYHRSPHRAHRPLPPANATLDFGGLFVVSGPGSPRRPYLEQAANVTGLELTIPEQTAWTDEDVRNFRSSGLSESHILTGSVKAWLSHHVVLREFLASGLETAVIFEDDVDWDIRLKNIQIPLAQRTVRALTRTTTDQRQYPWGYTADWDLLYIGHCGDYFGDVNKPLGVGHHHPHDLAGVPHALYVDHTMPDRTDLHPYTASLLSAFKLPEFTRVVHQSVWPLCTFAYAINRNMAERILDEIAPPKEDPAKNLVAFDAAILVGCRDYGLKCLSVTPELFHHMPGQSLIASQESKERNILLPPVDAAGLEQTHFRKETSNIQCGFSDGSFYFGTDNDRLELLKEQIGRKNRCLKMGRDPDSGRPAHYRHLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3S4</accession>
    <name>A0A6A7C3S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_269424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3S4"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="23993" checksum="E36D71C576964DC8" modified="2020-06-17" version="1">MTTPPRRTSQISRSTHETRVTIYLSLDGGVIPSTYTPSPSAHHAIQTSPTQNIDIDTGIGFLDHMLHALSKHAGWTLYARTQGDLQIDDHHSAEDSFLALGQAFKSALGDAKGLARFGDAKAPLDEALSEAVVDLSNRPFAVIDLGLKREKLGDLSTEMIPHCLHSFAMAAGITIHMRNLYGENDHHKAESAFKALALALRKACARVKGKEGEIGSTKGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C469</accession>
    <name>A0A6A7C469_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_206446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arb2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="307" mass="34549" checksum="759C6818B1E50D09" modified="2020-06-17" version="1" fragment="single">FRRLSTDLPKDPVYPADLKELGFKQTDDGHFVNIETGEYFAYRHTNNDRANEVRREAMTQCIRSAVFEALKEFDIKPLYCHGDTYSETADGPAVPILTTSRQSLKAKREVVMLVGEYNHDLGIFAYRLLMNEGGMEEGSVIGLLKQLQTLARPPGVIIFNPGQLLYSHKEKQAMSQTSWLARNKESALHEHYRIHPVHNYVTGHTTPNEHVATVLKYVVPEITHEGAKLYTIAISDGCENMLKAIDVQLEEDSDAWIGGAVEAFALMQTTHRPHEIKNAALRMFLNLRGRGWVTALDVPPGKLIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4I2</accession>
    <name>A0A6A7C4I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_213130</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4I2"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="324"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="405"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="474"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="857"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="925" mass="103828" checksum="E1FE4E83CCE0D1E8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4M2</accession>
    <name>A0A6A7C4M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_8482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4M2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10697" checksum="6039CC383E8774DD" modified="2020-06-17" version="1">MSVFLYLVKALATLPVLFTGIVSSLLMFIAFIKLLLFLGSPLTRFISQLTAATFQAIANLRYRTDNSLNTWYQTLPTTWIVQHRVEWRDESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Y7</accession>
    <name>A0A6A7C4Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Y7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18915" checksum="EC17CEE983B1E85B" modified="2020-06-17" version="1" fragment="single">MEIIWIQGRRVSFWLGDILRLSPSSSTEYALYYGLETRSSPQTQENKRYLIQAIPLILLESVNGTEDVKFVPQDCMPFHEDFGPFLRTPHSAKKFYTKHDARVVQLNVNFWQDEVSAARGKRWNALEHNFHVSANYYVAVRAKMKAPSMLRGLMPDLVRPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C542</accession>
    <name>A0A6A7C542_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_213624</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C542"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025351611" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2862075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="288" mass="31568" checksum="B714032DFCA88E34" modified="2020-06-17" version="1">MRFSLAALAAVLPFTSAYYKGFNVAAQNPDGSCKSQQQWTDAFNKLKAHPEHVTSVRVYASSDCGTLANAVPAAIAANVGLLVGVWATDETHFNNEKAALQQAITAHGSDWIIAISVGSEDLYRMDIDPATLVSRINDVRTMVRGMGVQKSVGHVDTWTRWINGTNADVIRASDFIGLNTFPYFEHASIDDAYQTFWNAVSVTRKQVNKISPGKWVWLTETGWPLSGASLGPAKPSVQNAQKYWTDVACDVFKKMHVFWYIDVDYNAGLPFGIFGKDGSAQYGLTKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C552</accession>
    <name>A0A6A7C552_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C552"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="430" mass="49133" checksum="7B8504C2B394B3B1" modified="2020-06-17" version="1">MAADTSPSHDGDNLHKRRKKNTSRIVARPPLLAPATQQRPDVPLAPEFVDHAAPATLPVRRLSFVYLAPEQVRCRPLFVEPQRFTGQVNFTMYAPGLVDIFAQTWHLRAYIHESRAKMGEWRDHVVINDSFGIENALRATEIINTPGSPAGAMAALFKQVTWLFFHRTIQPSRSSLVFSQTVHEGIQSLRAVLFQQPAPAQLGLLTPLVLLGFASFMKEQRRAVLDIISDVRRTVPTRAMDVIENMLERLWVYQDYPDEKRSWDWEATWKEVSNGFSLTQAGISDPFLSELLAPSYLWPDARPPLPEPAQYRVIYPPPSNYTPEQEQLTSDFNARWRPAEMPPPAQARGRMQMDSPCQAPEQPPRHPSEQPPPQIIPQHQQRVHIHNNIHNHIRNHFLSHIPIPSHIHIHTHSHNHTPCHIPLNTQITIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5D9</accession>
    <name>A0A6A7C5D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_243798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5D9"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="12">
        <location>
            <begin position="411"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="664" mass="74726" checksum="F6E9BA1BFB6024AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5F9</accession>
    <name>A0A6A7C5F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F9"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="617" mass="68231" checksum="7B8A369CC26D816E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C650</accession>
    <name>A0A6A7C650_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_268491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C650"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="19083" checksum="2D0817CCAC6EB318" modified="2020-06-17" version="1">MRVKKPVNTDMDLDDRSCIPRLKHTVSDRKNVSVVDQLPPSSSKHCNTPADKNPAINGRNFGEKILGIPTTPVFKNKDLYGSVPSHYWPNFSLPPSFGVANTPKYKQALSEHEPPSSTVRHPFPVLYSPPVNPKSNAHSTQANSIPYPYPEIDWAPNPPFLRPKGQFNPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C674</accession>
    <name>A0A6A7C674_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ebp2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_241726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C674"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="408" mass="45568" checksum="3CD40B6A162B3E81" modified="2020-06-17" version="1">MAKGSKLKAALDRHRGVHYELQRQKKLQKQARKRKRATDEEKPDRVAEELAADVAEADESADGWQSDEEDNEEGSVAMVDGSSSSEEDEGDETFYTAFGGSPEKQLNVYGGACQGQKDDEDDEDDEDAEGGIPLSDLESLASEDRDDLIPHQRLTINNTAALQRCLKSFALPSSLPFSAMQVVMSSEPVTINDVNDDGEREKVITAQAQYAANYGRARLKAEGVPFTRPSDYFAEMVKTEAQMGKIKDKMREDAARKQASIDARKQRDLKKFGKATQVSKLQERAREKKETLEKVKSLKRKRQGADLTTNEEELFDVALEDAAETQIKNREERRGKAQIQPHGRSQGQGKGAKRQKKDEKFGYGGKKRFAKSNDARSAADVSGYNPRKMKGKKDTKRLGKSRRAAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6V8</accession>
    <name>A0A6A7C6V8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_274943</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6V8"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="461"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="487"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="510"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="543" mass="58715" checksum="A2C1B0C750B2C41B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C742</accession>
    <name>A0A6A7C742_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_210700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C742"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="92" mass="10475" checksum="1E3BA49E385AB559" modified="2020-06-17" version="1">MSTPYESRNTDNGRSKKQSMAELKLRRLTELNQRLQEDLNRRRIAVSEAAADLIAYTDKEPRDFMVPSRWGQVPRGADPYAPQQQGGCCSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C778</accession>
    <name>A0A6A7C778_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_268490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C778"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120263" checksum="345FF4DA14E122DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C809</accession>
    <name>A0A6A7C809_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_292725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
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    </dbReference>
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        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="924" mass="103171" checksum="3E34C53E968D4F98" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C815</accession>
    <name>A0A6A7C815_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="18140" checksum="EEE87DA8E0D1BD0A" modified="2020-06-17" version="1">MANYRLPTVTEDDLIAFQYSHFGDDSVPINWFVDAATALGEDEDDGLGYYSDGTKRILTDTQVAMFRQKEVQELLKREETASQGAIAIGTLEGDAVKTLAKTARSKAKYRNDVPYEKRHKRKWEAYIQDQDPVEGSRTHRRIVRELDDQTSQEVEMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863610.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="286" mass="31051" checksum="5D9421A853A8D9BC" modified="2020-06-17" version="1">MYNASDPRFRRRLTELGETVENARGQARDGLFIVGVNCIQPCLTRISQCFEASCPGLNTQRSRRLRARSRGRAELSFDFYDDWDDDGAGTPNDELDRLLVGGNAGYGAISASQSRGGMSYVPERGEERGDKRGWIPLPDEGWLARVFGGARPPERGVKLKSEFEERMQQRPGCGSVAESTSSRSDLFLSDEDQQEDAVPLDDEFATVLERRPVEGDPEAGGRTRAVSSSSGGRRIKGRKGRASGSSNSSVGTRRTVSGSSVTQLGRGIEKQNKAGEGEDIPVDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8F1</accession>
    <name>A0A6A7C8F1_9PEZI</name>
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        <recommendedName>
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        </alternativeName>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5549158at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="31902" checksum="8DFCF2FA53088466" modified="2020-06-17" version="1">MVRESLVEGAVTFLRDPSVASAPLESRIAFLKSKNLTQEEIDASLARVGSQPSSTAAAPPPGYPLPQYGYWEQAPPMRRDWRDWFIMATVVGGMGATAYWAAKRYIYPLIAPPTPPQLEQDKAHVDEAFNKTFALLDQLAKDTQELKDAEKARTDRLDSALAEVENVVSRMKEAHEAREAEAKRMARDVADIKDSIPNAIEKDKKITDTKIQELTDEMKSLKLLIQARMQQPSKPDEQQQKQANGTSDTGIETPLGSAGRSMVGGRVSIPAWQLAAKKKAEEPEGEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8I4</accession>
    <name>A0A6A7C8I4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_274229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8I4"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22103" checksum="D8B5F984796FA558" modified="2020-06-17" version="1">MYPLYAEKGSYDQDCTSLGPGCPASRSPIGYQPNLGGNVILACIFVLCLLAQLVFLVGFRGRRVFCAFMCLGLFKESIGYGGRIMLHYNPFSISASWIQFSTILISPSLFLLAIYTTTKDLTIYYGSATSRFTRKPKKLTFLLALTTGLTLVLVIVGLSSSITGIVLLFPLIGMSLQTLNMLIAIGFAVYIRRKAEKERIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8L3</accession>
    <name>A0A6A7C8L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 480.64</strain>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863931.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="809" mass="90104" checksum="DCF35B86488D4CA7" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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            <begin position="1"/>
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        </location>
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            <begin position="23"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="121" mass="13100" checksum="5C8E6BE6509E010A" modified="2020-06-17" version="1">MFSNVKALAFVSGLLRLAGPAFGYSLIDEFQVIGSNGSYIGDRSFSRGYVARIDPSFNGFSVNYQVPAGESGRIQIYSSDLLCHPSQHASNYTNPSYPMLQAQSGSCVAMKHLENGHVTMP</sequence>
</entry>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40999" checksum="AF7A86D894927B27" modified="2020-06-17" version="1">MLLARVQVLHMALAALLLLLAASAVAAPQVSGVPTVFGFASSMLWDRDSCMSAFVLGRQLWTCRDSLGKYTFLSSSSSWADFNSDGSPIIQNFAWNLYGNQSTTDAYFTPPDGYGGTRAGERQDFTRYAFWPSSRPLVVSDGGAVKMYTWIAKTHVTLLLYNLQLNPGGALYRADYAPQGDDYETLPEVSIVDQDFWAEEAILYGEYGHIVVNDTAYLYGRLNGTAGTALAKVPVSQIEDRSAYRYYYAEGWSDTPPSIFDLDGAAAIPHAGTGGQGTFFWSDHFQAYTWIGGNVYASGDPGFYISTAPAPEGPWTEPSQFYQGEKGTARWGAYTMQAHPDMSPKGETILSYTKADLVLGAAHYTHPLIRVKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA13</accession>
    <name>A0A6A7CA13_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA13"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="319" mass="36407" checksum="ECDA97734872AF97" modified="2020-06-17" version="1">MLLLDYQNCLIESLLKDRFQPDATPSSIDQIVSDFDNVTYHISTPNSKTQIVISMRIKCFPELVKYGANDVLQREYGPWIVTPPESGYDFSVSIDLTQLPSSADDRNELIQRLALLRRNALAAPFEQAFDEFSELQQEAAKYTSEAAPAGVREGGAIRAIHYRDEEAIYLRASHDRVTVIFSTVFSDETDRVYGKVFLQEFVDARKRGVQNAPQVLFRNDPPLELQGMPGLAAGKGDVGYITFVLFPRHLSSAQKRADVISHIQTFRDYFHYHIKASKAYIHSRMRRRTADFLQVLRRARPDKEETKRKTASGRTFKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAQ5</accession>
    <name>A0A6A7CAQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_254141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAQ5"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="312"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="438" mass="47132" checksum="AB81AE5A6983686B" modified="2020-06-17" version="1">MPPRAKTRAKQAAANDSDDELNGTSNKAMNKAGVKRKAAPKAREPLKDRTNETAEEDEKPKPKRAKTGRKAKIAAVADEQIANEPPTQNPPTVPEVIIPETQPEVAETLIDDLPAREAVPPRAASLQPLPIRPSARSQVYIPRARSASVSEHINNRHRLPHTSTSSEYHALQQAYTSLLARHESLLSLGVHEASQNFSKLQTLSESKTRASNELITQLKKEVASLRATLASQTGELSASQARVKELEAGRKALVEERDGLKEKVARAMLPSAGGGSAVGASAGVGGGALPTVGAGSVGTSASVSNMETAKKKLNLYSDLTGLVITSIKTKDGEDVYDCIQTGRNGTLHFHLSLGTIPEPTPKRPHGKPNTPGKVANAKVEDLVEFGYTPFLDPQRDAELIEILPEFLTEEIYFPQEKAVAFYRKLNVLVTGPVEVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPG4</accession>
    <name>A0A6A7BPG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_12001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006057">
        <property type="protein sequence ID" value="KAF2857223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPG4"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF424">
        <property type="entry name" value="ZINC FINGER PROTEIN INDRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="459" mass="51484" checksum="BA03CC671C8136E7" modified="2020-06-17" version="1">MASRRRRSTTDEQLPPAKKQCIYYICEACKSSYTTKRALVRHFHGDQHRLNVGLPPADKFACSQCGRNFSREHDRQRHENETHRGIKRPAPRQKKAPTPSPSPPAPDGSRSWFDDDSSDSGDEFKSPPANGTPNPVPSVQSVRSLAADSAIDMEEGKVAFRRGSFGGSLSSDSAAEVARGVVAVAPATAEKEEKAEKEKPKKKRRTPWPHASLIHKPGAKVKQVAAPKADICIFCKATFGDELPDLLPHLRAHLDELQSELRCDDCQVGFVHKRDLTQHLASADLLGHCGFNFPHTTVCRGHHPPPPAPPPWARRRPLNGQSWLTDRDRYRMWLQLKNWEQSQLQAYVANVADIITKRNRRASVCYSIEALLRVSKGSTASYAFSIDSARSAPCDRGIDGPMDVRGLGERLEQMSLRRSPRVPVWRRRKDSVDHDETMTEAIQERRQWSAVPFVPRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPI2</accession>
    <name>A0A6A7BPI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_279429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MU006054">
        <property type="protein sequence ID" value="KAF2857270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPI2"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="467" mass="50837" checksum="DA544ECB702DE374" modified="2020-06-17" version="1">MSSLKRAQDFVSFLNASPTPFHAVQSARQRLEKAGFSLIKERDDWSSLKPGGKYFVTRNASSIVAFAVGSKWKPGNPVSMVGAHTDSPCMRIKPVSKRIAEGYQQIGVELYGGGLWHTWFDRDLGVAGRVMVSTGNGGSEMRLVRISKPVCRIPNLAIHFGGRTPFDYNKETHLLPIAGLVSAELNQNPAETTTNPLKTPLQRHHPYLIELLAKEANCKPTEILDFECILYDTQPACLGGLHDEFIYSARLDNLGMTYCAIEGLIQSLQTPLTNDPIIRLIACFDNEEIGSTSAQGADSNFLPAVLTRLASLGSTHTSAFYEQTLAKSFLISADMAHAVNPNYTTDYESEHRPALNGGTVIKINANVRYATNAPGIVLLQECAKRAKGKEGVPLQLYVVKNDHPCGSTIGPMLAAKLGVRTIDVGNPQLAMHSIRETGGTRDVEIGVELFGSFFGCFGEVGERIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQI0</accession>
    <name>A0A6A7BQI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_297145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQI0"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20175" checksum="060ABC31C2EF0505" modified="2020-06-17" version="1">MPKRNAPAGTAHSHSHQSQLSFHGRSATNKVTKSGVNAAAIDRKKAELPKPVVPVTVAAYDVEKSDHEEEDENEESLGPWNKVTEQQINDYWSARENSRIAPRVHQNGLSRDEKILREWDLSTHYGPCIGISRKRRWCRANGLGLDPAIEVLAVIMREDKKNTGRAYIDDLLTARTGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQY0</accession>
    <name>A0A6A7BQY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_266674</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="702"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="522"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1611"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1738"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1771"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1808"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1869"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1920"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2857666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1960" mass="215154" checksum="19854F050EBDB242" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR39</accession>
    <name>A0A6A7BR39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006037">
        <property type="protein sequence ID" value="KAF2857562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="26149at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45598" checksum="DD7C03F2EEF31050" modified="2020-06-17" version="1">MSTILQEAESACQRIMDSETNSEDVKNDIAFLATASRDSPEVRDRLANVDLQRKLTKYISSESADPTLRCLGNACTTEAGREAMAKLNLSWVTRHINQANNELLVKVMWNLIPNCKTAAENASDDMIHYYFPDMIRGAKYEHVENVNEYRSMLLDILYAIVSTKDGEYERLSDNMMNSFLELPGAVIDLPEEDYAVALDIILIYIKDPRHQEEMVGSDHLPRLWKVYTDLVDKRGNSELLAPFATSLLWHLSDISATQRFATYTTLKDEFIKKLLNVISEARVVDVERLHVACQVVGNLLVKTSPKTTGYLVTDQRLHAPLMEAMVESSDAEFLHSAGGLLNQLARAQEAKDIMGEDPNAEAALTKLCTNANTQLKQDGLRLLKTMGYLCAANRTRFKSLAEQVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRG8</accession>
    <name>A0A6A7BRG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cell cycle control protein cwf4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_260422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006026">
        <property type="protein sequence ID" value="KAF2857831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRG8"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="49" mass="5737" checksum="877ADF51AD6C9458" modified="2020-06-17" version="1" fragment="single">PALDIILFRPADPAHSEFNHITKLLHQQLLNQILKPTPVIEYAWAMRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRW1</accession>
    <name>A0A6A7BRW1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000124">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="207"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="38255" checksum="6CD9BF6F6DE0EFDD" modified="2020-06-17" version="1">MSSSNRIRAHNSRDTDVERRLWKEIQDKAIEADSLMNRSNENGAQIIHLEERQAQLIKDGNPASAIIDEQLESLYRANLQITKSIEEIVRGREGVNLLERINVLAGLRESSEEQHVSSQSGRGANNAKRKAIRSGGKLISTIEDDTPSPRISLGPASRLGVKERPSRAGSLPGTREVSVKVEEAESVGSSADAAAVSKNVPVNSRSNRLVLKVGEIVFCRHDAKNYDIKKGEPPEGEGILCRVTNVIGEGKQRRYEVQDADNSGDPPPPQRASVNQLIQIPDSGKGLPDLPKGKGVLAQYPDTTTFYKAVVSEAWRGSVKGDVLVKLLFQDDQEVRGVERRFVLTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRZ4</accession>
    <name>A0A6A7BRZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRZ4"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="25082" checksum="5CC632AE19699C70" modified="2020-06-17" version="1">MAPPTVSKQAYDILAEEAEHWYAEWGHLQEKRTDLENQLREATKSSKRADLLQGERDDLLLELAAKNDELVQEKTRALRAQEALRDAERMYRQHSLRADYNAEEAVRLLKKLDSLGELLHEGHEEREKMQEDLEALRRKFERARAERNEAVERLKVAVRRGRALNASRNERAEPEEAQGNFQTTFTWETRDGLKLQDGGDVERLCRQVMRFIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS11</accession>
    <name>A0A6A7BS11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS11"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13186" checksum="951CAB9363B7787F" modified="2020-06-17" version="1">MASVPSRTLPTKAVSGATLSFSNPRVQAPSPKTCTPQASRRPVPFQSSTRGQPTSAPAGHPVQTTVTQSRRQRVAHSLSLRPAPVTTGEFHARMSELKSDDANYLVKFCRVDFCNMYAVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT86</accession>
    <name>A0A6A7BT86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
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            <begin position="565"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="1110"/>
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            <begin position="1007"/>
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        </source>
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    <sequence length="1653" mass="183265" checksum="A66B2F87E90930E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT96</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    </dbReference>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_296584</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
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        <text evidence="1 5">Belongs to the SEC15 family.</text>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
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        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="129"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="479"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="866" mass="97351" checksum="E94AC7595EBD8842" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTD7</accession>
    <name>A0A6A7BTD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_148851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTD7"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="26519" checksum="44C095C912652BB3" modified="2020-06-17" version="1">MASSSFRDGINRLGWSRRPEAPKQQQPLLDRLQGWNPFGGNDYLRLPTHEDEAPGAPLPAPTRREEEEGWFVLSRWDRLLIFGGLLTAAVALFTISLTLLPVLSLRPRKFAILSVIPPLLAPPPLSSLPLSPQIALTCSSWSMASAFFLISWAVIMGPLPYVRHLFSQERVPFTATYFGSIALTLYCAVGIRSTLLTLPCALVQLVALIWYLVSYFPMGSQGFRLAARFGGSRMTAWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE7</accession>
    <name>A0A6A7BTE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_221050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE7"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="53"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="220"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="364"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="711"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="883"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2858531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125592" checksum="48FE1F0B277F110D" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Lutzoni F."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858139.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="607" mass="67633" checksum="891AC18AC225A3A6" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="426" mass="46168" checksum="5651927638852F41" modified="2020-06-17" version="1">MPQPRPRSSRSLFKQPLPTIVEQQWASSSSSSPPTTKEIYTLPTSSLPKRSSSIGQTANPPPEHPDRSKHEATLPKMILSIHPETTTVTPGFTIRGQINLSLAAQSTVTHFEVSLHGTELIPSHEPHTFFSTRAATLPVPRGMIQVLQLPFTILGTLLPRNLPPTFFSEVVNVRYTLHSTAIVTVDAKSFKLLASREVTLISPPPPLGAGSDVLGSPTLASNKGLTARLDRITFPTGGNLRVHLSFSSKWTGTGVVTLELIREILLGTLRDVVDRGVESVVATVNYSVVMDERDVSITLNLPRSGSGFERFPSGTLEVRFILRVRVKGQREAGVTLPVSLVDVESLLRGEGGGTLRGSRTIDGINLGGGRDVRAVKSLDVIGGKPDGRKEAVTDVRGSGNGGGRDQPRGFWSWERWRGLIGREQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUC9</accession>
    <name>A0A6A7BUC9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_221471</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25048" checksum="004065883E54088E" modified="2020-06-17" version="1">MSLTFKLLSLAIRTAAKPIGNQIKKQAKEHEAFRQFAVRQAQRVHRIDMRMRLGILHDPETQQKLHQREQRLAEEKKRKAETPTVRTEAEQAKHDEEVEKERLRPPAEEKVPKVKIRPLSEAKAIELGANFFSEAFIFAVAAGLLVWDSWRSRRKESARRDVVAEKIDEHDEMIVKLQKMIEEQGQTAERLEAILRERGSQQGGSRQKGSQRTGGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUD2</accession>
    <name>A0A6A7BUD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF572-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_282944</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27753" checksum="BF45F411ACC1CE29" modified="2020-06-17" version="1">MQNVNRYVPPDLEGTISANSLRGRRPPGSLRPDGTQTVRFEMPFDVWCDGCSQPTLVARGTRFNAVKSRVGSYLSLPVWGFRVKHTICGKFIEIRTDPANAGYVAFEGGKARAAAHPEEEKPKGAFADLENQAREKDDKERLNQLLSFQKRRWESPWRVNKALREDFRAEKKRLLEKEREKEAIKDKLGTDMDILPERKEDVDTARRIFEKRKNIVRKREGKDELRRRLVKNTRAAGMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUD8</accession>
    <name>A0A6A7BUD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_114878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUD8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="88" mass="9736" checksum="613684C214CC917C" modified="2020-06-17" version="1">MPGYPYTANIVHAFSTATDLGASKDVRTLLNPLQRCTSSFLFTLLQTHQPLPPIIPPPPPPPPPPPIPQIPNVFHTPSLAKWLFIYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV03</accession>
    <name>A0A6A7BV03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cdc12 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_220968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV03"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="316"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="383" mass="44383" checksum="49F20E29820257F8" modified="2020-06-17" version="1">MEGREVLGGPIGIANLPNQRHKIVAKRGASFTIMVAGESGLGKTTFVNTLFSTTIKGYADNRRRHSRQTQKTVEIDITKAELEERFFKVRLTVIDTPGFGDYVDNRDGWQPIIEFLDDQHESYMLQEQQPRRTDKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLSTRVNLIPVIAKADTLTPYDLARFKQKINAVIDAQGIKVYRPPLEEDDEAGLQHARTLISSMPFAVIGSETDVNVDGRTVKGRQYDWGVAEVENEEHCDFKKLRAILIRTHMLDLIHMTEENHYEMYRAQQMETRKFGEARPRKLDNPKFREEEEALRKRFTEQVKVEEQRFRQWEQKLIAERDRLNRDLETSHAAIKALEAEVERLQGAASLRGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV87</accession>
    <name>A0A6A7BV87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_259145</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV87"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="437" mass="48541" checksum="159DBF142555703A" modified="2020-06-17" version="1">MNLPLSDPTSLIHDIPEILICHVRSGGQAVCLRFSHAGDLLASGTTKGQIAIFDMDTYGIARKLLGHTPGKPIQSLCWERSGRHLLSSSVDWRVILWDLNDGSRIHAMNLGAPVYIADMHPLEPRRCVAALYEFRPTDVNLETSVASPLGNGPKGSTDVKHFTTVAVWTLGGRHILTGTTKGYINVLDAFTHKIVHSMRLCSKPILLMRLSKSGADLVVNASDTIIRTIRLPPSLTSPAPDDTDIHLEVEHKFQDVVNHLSWNSVSFSTNGEHILASTLLSHKIYIWERGHGSLVKILEGPKEELGAVEAHPYRPLVAATGVESGRVYLWGIKTPQRWSALAPDFMEVEENVEYMEKEDEFDIHPQEEVQRRRLDAEDEVVDVLSVQEGDGRSAGFRLPVLLDLEESDSEDEMVLTGVGQYRRKEAVRAEEGETFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWP2</accession>
    <name>A0A6A7BWP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_265218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWP2"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="262"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="418"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="581" mass="64863" checksum="D0296F1206C49D80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWV8</accession>
    <name>A0A6A7BWV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_295587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWV8"/>
    <dbReference type="OrthoDB" id="5132737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="117"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="245" mass="28253" checksum="8EF7245E4DC52B66" modified="2020-06-17" version="1">MAFDVPGAKRDCDDDVPLESNRLMKRRAASHSFDLDGPNDPIAHWALDSSWPAVMSKLPAKSTLKIQLKHYKKDVFDYDCWRRYGVGSFEPMPTQRLGNFEYWEEKGPWKIVNPLRRTSDRKWRLKKNNNRPWPTISIGLEKKAFTSSQLEKLEIYNTDRPATFSTLSKQFFPFSVGEILAHGCDWDKGKDKESLDGSTIIDAIVQLCDAVKPEEIDELQARVLGFGMVHDDEDIFIHGHFFTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWY0</accession>
    <name>A0A6A7BWY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Restriction of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_220039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RTC1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
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        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="908"/>
            <end position="952"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859008.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="966" mass="107029" checksum="09592D138FF54112" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX25</accession>
    <name>A0A6A7BX25_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_95880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
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        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="58"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="428" mass="47678" checksum="309F880A77B0FA26" modified="2020-06-17" version="1">MSTAALANITECISPFLNVRSYPTTGGETASRFCKPLNANLTCCLPCPLTDWVFDDHIGSQIATADHLSIGGFVLNVLLLLTFWILPEEKTMRHYLSVSLAVSATIMSLAFLIPLGTNPNYCHDDITPNNMNTDTGCAFTGSLLLFGWMGCVVWIMLRSIWTMLRIVVDFQRPIAYKWVALTLGIGLPAFYLAICLPISGVAYRLGDVCIPSRTSAFATWFVWVIVFSTLSTLILIFTIVYCIWKFALSVVSRDRLDNEVTTSTSFIQIQQTKKKSLQRRHRLEWARIKEVLLMQWRTIILTFIIMNESVYFAIVFAQQTGAAEAALHGVRKKDIEFASCLMMNHGNKNACLAKATGMGLNQAQVVATLILASANNSVPDIFPAVPRVNAHGMEASHLQSAKPSRTKSQAESRQRRVCHAESWQRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX32</accession>
    <name>A0A6A7BX32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_197211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX32"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="453" mass="52656" checksum="BEB8BA9946CCFB7E" modified="2020-06-17" version="1" fragment="single">MSLDRSPSRSHSGGWSSPGLTEDSGCKSYGQLDVTWAGVKDGKRKAYPRYQTRNEGFFSRHYRRISEGLLQFVHGMSDGNSKDRRRPTAGRLKGLPRRIALLLSRRRRYTALALVLLLVVFLWFQQPLAHWLHRASLLGGGSKFVIILGANQGGGVMEWKGAREWAIERDSVRNKKAYAAAWGYELEIVDMSTKKRYAHEWRESWEKVDVIRNSMKKYPKAEWFWWLDLNTFIMEPRYSLQKHIFNNLARNTYRDINLYNPLKIQHPPNGTSGDPNAPLYANYLDDDTLSPVGDNNPASINLIVPQDCSGFNLGSFFVRRSAWTDRILDIWWDPVFYEQKHMEWEHKEQDALEYIYSNQPWIRPHVAFIAQRLVNAFPPGACGDDKGLPPNGCDHLKEGDEMRECGIQGIHYQQSERDFLVNMAGCEWGRDCWGEMYNFRTLSNKLNRNRWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX76</accession>
    <name>A0A6A7BX76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_95632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX76"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025684132" evidence="2">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="34655" checksum="8D1CCD8D558AD720" modified="2020-06-17" version="1">MDHSVLILLLAQFAVIMCLALFHGLAYPNQRPPGALPVNEKPCQPCPAGPAGPAGPPGPPGPAGPAGPPGQACQPVQACQPCPAGPAGPAGPPGPPGPPGPAGPPGPPGPSGQPCQPCQPCPPCPPCPTGPPGPPGPPGPPGPAGPPGQACQACQPCPAGPAGPAGPPGPPGPPGPAGPPGQACQPVQACQPCPAGPAGPAGPPGPAGPPGPPGPSGQPCQPCPPCPPCQTGPPGPAGPPGPPGPPGPPGPPGQARRPCRPCRPRRPCRPRRPRRPCPPCPPLHPQPVHPSSVQGVQFTGFSLECLDETWRRRVLDVVRIMKQKVSVPIMMDPAIALLTLDQETRHLHRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXC1</accession>
    <name>A0A6A7BXC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_271293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXC1"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19459" checksum="8A40D44AADF85E23" modified="2020-06-17" version="1">MGFKESFLQIHVNERPPPGTPAPKFPSLYWPFPVSGTQVQYLYKPKDMWKFTLYWTLICVVTVHLAVAAYACGVHLLFRGGKRIGSQDNVPKARQGEKGSPSKTGHQRSSYKILVIIPLYLFIGGMEGLIAGNVVGGLLGGVYKSGFFRMSTWIPFSWGLANAMMLVVSSFAVQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXE7</accession>
    <name>A0A6A7BXE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_258422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXE7"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="280" mass="31702" checksum="6CCF139E71EC63B5" modified="2020-06-17" version="1">MGWIWADPTPFSTTAAKPPVRIVTTCAVSRADCPKPSCPMHKQDPKPSSMNPLNRMFSHISNTRDAPQQRVALPRERELSTIPRGDGTGNWEYPSPQQMYNAMLRKGYSDTPAENVEAMVAVHNFLNEGAWEEIRGWERRFSHGLLEGWNACKKGENTPLPPSLQKSEEPKLIRFMGRPGEPTPKARMLGVLAWLYPAKFPDNPPFDRHDWFVERNTPTGKKEVRYVIDYYSGPPEPTGEPVFYLDVRPAVDGPVAACERMLRWGGDVWWKASGGVVREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXJ8</accession>
    <name>A0A6A7BXJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_218179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXJ8"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025400105" description="Ubiquitin carboxyl-terminal hydrolase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="38"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="398" mass="44547" checksum="6E9D21519855560D" modified="2020-06-17" version="1" fragment="single">YVTGASIAAATLLYVLAPSLFGNGSTVRHAKSQANGVVGLTNLANDCFINSVLQALAGLPSLREYLQGVRDNRPANTESEGKDESLRFGWVTMGLKDMLDALSNSKTSSKTINANGFIRVMENALRGRISRSQQDAQEFLQIVAQRLEDEHRAMAMSGAGVEGIGFPLEGQLKSQVECTHCHFQPKPSVSSFVILTLHVPPESATLNSCLDGLFKVEHIDGFLCDRCRVEHALQLNNKEIARSNLPEEDRVGLEENISKLEEALLDPEQPPADVQLPLSSVAPRRRIARHTQIASFPRILALHLSRSMWESRSSSKNMAEVDFPESLMLGGLLNRRKYRLSSVITHRGGHNSGHYETYRRNQPSERWWRISDEYSRQCKTTHVLAARREVYMLFYEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXT7</accession>
    <name>A0A6A7BXT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_208077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4064873at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF4">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="550" mass="61212" checksum="BDBC2EBE4108BF42" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY52</accession>
    <name>A0A6A7BY52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_258654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
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        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
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        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="933" mass="105291" checksum="FD58A93423CC46B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY79</accession>
    <name>A0A6A7BY79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_74048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19110" checksum="E164230DC95A7812" modified="2020-06-17" version="1">MNGKIFTHHRIEPGSLWTCREHRDVAIKIRVEDAPPSLERGIVKNLTGQSKHPGMAYIPVVLDEFELVGSTGTRHCIGTKIYGVSVKFALVEYGLQLTASAAKRLQHQVLQAVDCLYQHGIVHGDLYTGNVCWKTPGINNLTEKEFFELTYIESSYTGRKLPNSIISSMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYB7</accession>
    <name>A0A6A7BYB7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="252265at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="160" mass="17495" checksum="7A4BB23B57798BBA" modified="2020-06-17" version="1">MQHMRRALEEAKKSPPKPTNFCVGACLAEGDEVLVTGYTLECEGNTHAEQSCFIKLAQQYGCTVEDLGPRLPEGTVLYTTMEPCNKRSVGNTPCVDRISALKREDGSPAIKTVYVGVREPETFVGVNEGEKKLREAGIQMVHVPGMEFEILAVATAGHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYI8</accession>
    <name>A0A6A7BYI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_264716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYI8"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33428" checksum="FA5A6878F0B0850D" modified="2020-06-17" version="1">MPKKTGVKSKGNGKCVAKIQPESAPPQRNTRQRTSGAATAPEYTQKSRRTGGKTRGTPELEDSLVLPRHVNALENDSRRRITTDCMPEDDQIDFGDYDAEVEIDQQSEVAGVRPIQVPTAASNKGASAEEVLAFAQGTNPMEPGFMRTFLGINSPVITNSVIPRGLQLVLRDNAELRQELREVKVQVTSLVANVLQADYLSTFNLVDWPATYARKAALVLRPSRMEQRPKDCGGPCSLGSLSNWPGREVLKVIGRVRSDYLPKMKTRLDKVLENPLLDDVKALADDNDLTAEQCMAEQREAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYS9</accession>
    <name>A0A6A7BYS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_264508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYS9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27537" checksum="E3492B304A13207F" modified="2020-06-17" version="1">MIGVFSEAREQSRHNSKLGVNLCTVLKHEAIPEKYMLFRAQCVQIRRLLAEAKQTPSKRSTRRATIAGITPVTPKLKFRAKSELPSTGPKIIDRAGKKKEDFGIQSKEELREWLSWSKSKGLFCFGEDALNLESKARAYYDTWQTRKDKLCAKVEKMVANDPPQPVQNSCVRVEPYTFPCAECVVPISHKSGGPKADVADSRPSPAASSGDLQVLHAVALAQATECRRKLPMIPVVFNVLLPAHLEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYU4</accession>
    <name>A0A6A7BYU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LUC7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_270582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYU4"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A7BZ16_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
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            <end position="115"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13784" checksum="287190EE4CD93DE8" modified="2020-06-17" version="1">MCQRRFMICMHIAVVTSFATELERAAKSLSIFKLAYSANIPGTSWYTRVRQGLSPTDHQRAFFHFWRAQRGRMMILRVVLKMNNKFLIIPCPRTNMQPWRHVYSWRVPRYSYHST</sequence>
</entry>
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    <name>A0A6A7BZB9_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="EMBL" id="KAF2861154.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
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    <comment type="subunit">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="55"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="426" mass="46445" checksum="D4E14BE5288B660B" modified="2020-06-17" version="1">MLASASVRSVRRAGARSTVLQAVRAASVWSNVPQGPPDAILGITEAFKKDSKQGKINLGVGAYRDDAGKPYVLPSVREAEQRILKQNLDKEYAGITGVPDFTKAAAVLAYGSDSAALKEGRIAITQSISGTGALRIGGAFLERFYPGAKTIYIPTPSWANHKAVFSDSGLEVKSYRYYNKDTIGLDFDGMVEDIKKMPARSIILLHACAHNPTGVDPTPGQWRAISDAVKAGNHFPFFDMAYQGFASGDTNRDAYALRYFIEQGHQPCLAQSFAKNMGLYGERVGAFSMVTASPEEKARVDSQLKIIVRPLYSNPPVHGARIASTILNDADLNRQWLGEVKGMADRIIKMRALLKENLEKLGSKRKWNHITDQIGMFAYTGLTPEQMGQLAKEHSVYATRDGRISVAGITSENVGRLAEAIFRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1U4</accession>
    <name>A0A6A7C1U4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1U4"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="26923" checksum="1FA51419A693AD4D" modified="2020-06-17" version="1">MLRHAHLGLTSYAHANELQQRLVGAMLAHKADPLHSPPVPPTVLTAEFHPVYTCGRREIGTVSAKQQAYLTSASYGGEQAEFYEAARGGQTTFHGPGQLVAYPILDLRRLRLASRDYVRMLEETAMETCARHRNIQPTRLPNHPGVWIRCEGSETKKICALGLHLRRHISSHGIGLNVSTDLRWFSRIQACGLDGRLTTSLVAEGITNTRPLDEGIALVERLASRLAGVHDVEDVNETELFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Z8</accession>
    <name>A0A6A7C1Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_214918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Z8"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="38250" checksum="CB9C0026984E42CA" modified="2020-06-17" version="1">MHTANGDSREAQQRIHLVGIGSIGKLVAHSLRSSKNPPPVSLIFHRENLLKAWNGKVTICRDGIETSATGFDVELNSQSHEAIHNLIVTSKAHLTASALLPIRHRILPTTSICLLQNGLGVVEEIKRKVFLDERTRPIFIQGIITHGVNVPFTIAQKDTFYAVHAAQGTVSLGLLKANHQKPNHLIKVLERTGALQAADIDPSELFKQQLEKLVVNAIINPLTSLVDDCNVCICSSPMLRDTIQLVIAEIGSVIRALPELSAKAHKQRFSDEHLFNLVMSVADKTRTNISSMLADIRAGRQTEIEYINGYIINRAKTLGISCPTNTAIMHTVLAKSIAAHQRRVANDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C210</accession>
    <name>A0A6A7C210_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_216648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C210"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="221" mass="25098" checksum="7B5DCD794AB4D6D9" modified="2020-06-17" version="1">MAILIDENLQGNKKLESDQLLGQTTSSLHKLKDVNNCDGGFFVFGDLSVRKVGRYRLRFHLFDANRPLGMAQLLAWVDSQPFNVLARKDFEGLRESTHLSRAFADQGVKLKISKGSRSQYVSIPQHRTNLMKFQEAQRHGTAATSGTRFMYETAAIQRQHAMELRVCRAGLWQHSPLSNSRTATTRTSTTDIYPPSRNPMEQQCKSLPKLFRLIKLEDCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2I5</accession>
    <name>A0A6A7C2I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_215041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2I5"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="239"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="552" mass="61314" checksum="75F194CA6415C24E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2I7</accession>
    <name>A0A6A7C2I7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_47340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025432012" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10344" checksum="7BD2DC3E1DCD6EF7" modified="2020-06-17" version="1">MLLICGFLMCFHSSNNIVFGVVLCFEVFMEEHWNGRDLLRDGPQHVLEICLVSVSLRVTRTCLCLSCPALLQYCFPHGHGCLTAVDFSLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2K3</accession>
    <name>A0A6A7C2K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_256648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2K3"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="99495" checksum="4899EC089D8AE9B4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2U4</accession>
    <name>A0A6A7C2U4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2U4"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="34715" checksum="68E928BCF7775341" modified="2020-06-17" version="1">MTTHSSGSKAIDPTEFPPSTSTLPPTAAEPTTLTSPAEARTAEEHPPGTLSLRVERAKRLAAQLAISTHFSSTMSYIGIGSGSTIVYGVDAIKAHLSTHPPPAGHTNYFVPTGWNSRKVIESAGLIPIAFDSLPAGRELDVCFDGADEVDEELNCIKGGGACLFQEKLVACRSRKFVCIADWRKDQKRLLTSWPSVPIEVAPIAYVSVLKELEGLGAKAPKVREHTISKSGPVQTDQSFYIVDAPFARLRNGLDGEGEGEGWDVISLARAIKEINGVLEVGLFCGLNGEEAREKGVPGGQKPVAVYFGTEDGEVYVKTAPERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Y8</accession>
    <name>A0A6A7C2Y8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_42582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Y8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="22571" checksum="79946E7BC38059B5" modified="2020-06-17" version="1">MTSSNSIECLIPSPYRMLSKRRKPKLPPSNCPLCHEKGTHPTLTTRDKLSGEHLESKHLENERDKQTTGPELYQEYLDFAERYNAEGVRRVVRDKRAVEAAEAAARIAEQAASAEAQGPSWAITHADTANDLEELGAAYAVDQHFEDKSGASAYQMNPEHNDEVRSSLNSECTDDQIDDSGACEYSGPGRGGGGRVMMNAKFSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C353</accession>
    <name>A0A6A7C353_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_229163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="267397at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39533" checksum="6A7493FBE42A1794" modified="2020-06-17" version="1" fragment="single">MADNGDEETQITIQIKYSGENKHSLTLPLSTTIGSLKQTLSTSDYADIPVERQRLIYSGRVLKDDDTLDSCKVKDGNTVHLVKGAESNLRQNPAASSAVPSNIAAGTGAGNPLAQLTGARYAGFHGLPGRDAFGADGGMGAPPNPDQMLRMLEDPALAQQMNEAINNPAVLEMLRNTPMIRNNPMARAAIEDPELRRMMMSPGMIRMQLQMQRAMGQGGEAFPMPGETDTTESQHTRSGQPSGHPTSAPSPFGSSSGAREGAQGNRANPIAAFAQQAMHNPRMLQQLQQLQQMQQMQQMMGSSDRAPSPFGHAPADERPPEERYESQLRQLNDMGFFEFERNVQALRRSGGSVQGAVEYLLSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C369</accession>
    <name>A0A6A7C369_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="819"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="313" mass="34330" checksum="E64BD6FE118F4670" modified="2020-06-17" version="1">MAAGPVLAVGVCEALGWTWVYGIAALVACSSALLCVAMQESRPSKLLSERVELVAQQSGYKHLTTDTEDSLPTLKEFFRKSLWQPIRLCAEPIIVVVSIMAATVVAVVYLFSEVLGEVYITGFGFSERDYSLVFIAIGLGAIFSLLPRFYDVHVAKKRERNNEILEPEDKLFGFYLAAPVLACGLWWFAWTVPPLVNIGSWPSVLALLLIGYGVVEFDSALSGYLTDAYASYAASASAPMSTLRATLSGVFPLFGRKFFVAVGNNYALSILASFATCFCGIAVLFRMYGRRIREKSPFAISNRESALPMRKFT</sequence>
</entry>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2861648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="49" mass="5538" checksum="7CD5966122B4C8E8" modified="2020-06-17" version="1" fragment="single">RTIDPLFAMGVGAAAAALRIRREEKTKGNTTAQSWEALKRRVDLVWRNL</sequence>
</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="418"/>
            <end position="492"/>
        </location>
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            <end position="732"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1073" mass="116467" checksum="6662314568CDB650" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
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        <text evidence="2 9">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DNA damage-binding protein CMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002653"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="516" mass="57264" checksum="EB5AC33E16197C8F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4R4</accession>
    <name>A0A6A7C4R4_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="165"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
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        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="38555" checksum="D02B8F3A58BC466E" modified="2020-06-17" version="1">MAKRQRKTGAEPAEAIVPASKRQKTSQTGLGFLVDDNVRGEKPLEARLTNGVPKTKATRVDESHAKVLADTGAENDDSSDASDAEDASSESDDDEADGVEDGQANGGSDVDMKDGPTFGELALTRHADPIEVESARAKDTTTLVRKEASATTSLSSALTQALRVNDTDLLESCLKINDLPSIQATIERLQPTQAVTLLVRLSERIHKRPGRASHLMLWVRWTLVSHGGFLATQPEPKARMRTLSQVVRNRGNGLSALLQLKGKLDMLNAQLELRQRIEANKQSDAETEEVTVYVEGESGSDFNEDDSSDDGQAGDGDDVASRSSLSDEGDESSVELVSDEDSGDASDYSSDSERSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4U5</accession>
    <name>A0A6A7C4U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_291444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3938460at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21862" checksum="FCC9F12F9BC85FDB" modified="2020-06-17" version="1">MDAALSELYALVENGIKPNFADTAKKHLGLTVDRDTALKARRSLSQEQEELIKYISFIICQQDLGKNWPGRFVERNRKNLDCRYLNGIDLLRHKADSRESYRAYFEVLEKKIQGLEIQPENVYNMDEKGFLIGKGQKTKRVFNRNHYEQGQMIGAGQDGNHEWVTVMATMCGDGSTLPPAVIYASATGTVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4X1</accession>
    <name>A0A6A7C4X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_213473</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4X1"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="40"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="41827" checksum="7541A8BCEBD765DF" modified="2020-06-17" version="1">MKTTTLPVNAHKIGALYPIKHPEDLLSDLGITIDRDSADGQNLLRAAKELRCSDLPVAFPTETVYGLGGDASRPESIKNIFRAKQRPTDNPLIVHVASLQQLRTILSHGQGEVQEDPIPPIYHPLIKQFWPGPLTIILPNPSNSILAPEVTAGLNTFGARMPRHILALALIKLANVPVAAPSANASTKPSPTAAEHVAFDLDGRISTILDGGPCDVGVESTVVDGLSDPPVVLRPGGISIDQLRTCPGWSNVQIGYGNVPVGRPRAPGMKYRHYSPKASVVLYGPGREPPTTEELHRLVPGENGKIGIIRTQRWPTPIYNPQVPTIMHMFIGPDATQIAKCMFGALRQLDQEGVETIVVEGIDDGDGDTSAAVMNRLRKAAELVVPDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5H1</accession>
    <name>A0A6A7C5H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_26428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5H1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15448" checksum="F023C0D140CFB4F6" modified="2020-06-17" version="1">MGHLFLCQLSWYCHTSSPYSGHKLCTQFDPLYPVSDTLIHYPHLPLVPSTSSSLGTKKVDLKTGDDGVVFDSDRIASDDFHLGRRAKYFHENTPRFPFLCRCKGWEVKVGRLKICLLRRSCVTSKSWSLASSAAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M9</accession>
    <name>A0A6A7C5M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_280773</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M9"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
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            <begin position="565"/>
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    <sequence length="839" mass="92280" checksum="DCCA484A13633D87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6B5</accession>
    <name>A0A6A7C6B5_9PEZI</name>
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        <submittedName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="4">Belongs to the cyclin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin_N"/>
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    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="270"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="363"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="367"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="492" mass="55439" checksum="F7ABF281B915BD4D" modified="2020-06-17" version="1">MDAKPQRLRALRVQDENAPVALPAAVAKVAGMKSLNKRTKSSPALSALVQGGAARQAKKILGDVTNRRVVKDDSEIGKASPDKIVVRDVAQPAPAALTRPATRPVAPKARNAERAIVVKDDKAWDHAPPQSRHEESRRAVQSQRDSTDQRDALPVSRPNDTVETEVYDDSYVATQSFGLHGDQDGATTIIVMPECSEQVRRELRAAAAVVEETILPEDVEDEKWDISMVAEYGTEIFAYMRKLERSMAPNPRYMEQQAEIQWSMRAVLMDWVVQVHQRFNLLPETLFLTVNYIDRFLSCKVVSLNKLQLVGATAIFIAAKYEEVQCPTMAEIVYMVDGGYTAEELLKAERFMLSMLQFELGWPGPMSFLRRISKADDYDLETRTLAKYFLEITIMDERFVGCYPSYLAAGAHCLARFMLRKGDWTPAHVHYSQHTLKQLRPLLTALAECCEDPKRHHGAVFEKYSESRYKRAATFVSAEMARGFGLPDSRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6C4</accession>
    <name>A0A6A7C6C4_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_199781</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="8361" checksum="DF9E3618259E616F" modified="2020-06-17" version="1" fragment="single">NTLHWSSVKCKRVTSSVVASEAYRMTHGVDIGAPRILTDKLGLPLVVCINSLSLYGCIVKLDTAKEKRLMIDIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6K1</accession>
    <name>A0A6A7C6K1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_195602</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14269">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025409651" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50598" checksum="66395508087ACD45" modified="2020-06-17" version="1" fragment="single">VLALWVVQQLLLPLVVWTLPQLEGPLYDGGLYGPYRVQTYRSFNLTSPLMSVVKWDESCGDGYVFLDPNGPSVNHQGPLIVDAHGNLVWTSEKYKTTTTSRLQTFNGTEYLTFWSGRKDKTTGVGQYYMLDNTYNVVHTVNAVGEDLHGDLHEFEITHEGTALVAFYNTTQMDLRRLGQFRSKNGWVRDSGFQEISIATGELLFEWRASDHFSAEETFMSNPLGGYTKGSPYDFFHLNSVSKDSKGNYLISSRHYHAIYYLNGTTGHVIWGLGGHNTDFVDLSSGEASSFSWQHHARWLDESSGILSLFDNSYAWPHSNAPYSTARIIQLDFTNSTATLLHSFSSQNHIASSSQGSVQRFTAQDAKQHYFIGWGSSAAFSEFTTSGTLLCETHFSPSIAFYWERIKSYRAFKALKWDATPYWNPSAIHTGEAVYVSWNGATTVHTWTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6P9</accession>
    <name>A0A6A7C6P9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bet v1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_280541</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="16889" checksum="1443613AD2FE8364" modified="2020-06-17" version="1">MSSTAIPTSTSVEVSTVIRAPLSHVWHLIKLQEFNKFWSALSQSEFVKGASDDTDVVKWTFKDGTVLEVKQEEHSSINHFVTYSIISSKPELSYSSVLSTIRCFPVTTGDLESSTFVQWTATFSSDADAGVIADARYKRSEALADLAKVATSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C781</accession>
    <name>A0A6A7C781_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C781"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="427"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="883" mass="98622" checksum="7345B3596ECDA9A3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A7</accession>
    <name>A0A6A7C7A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="377"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="568" mass="63173" checksum="DE3C92EA648D7B96" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7I0</accession>
    <name>A0A6A7C7I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terpenoid cyclases/Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_280159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7I0"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="4"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="40621" checksum="8A2EDA72050E129E" modified="2020-06-17" version="1">MPFNKPLQIKYWQRCLHSLLPSAYTSNDSNRLYLAFMIISALDLLSALPPPELLAPYINFIYTLQHPGGGFRMFSGTDLGGAATAENAIWDPAHVPATFFALATLVILRDDLERVRRDATLSWLRRLQRQDGSFGETLHGEEVMGGRDTRFAFCVAGVRYLLGGGDVEGDVDVDGFVRGVQQAEESSWEGVPTTGRYREAHAGYLYTTLGALGLFGRLNSLKDGQGESVSGDMRAPILPLNSVRWLVNLQAESPGNDYCAGISGRPSKPVDTCYAFWVSASLEMLHAPLYDRNKLRNSVLDASHEFLGGFAKTSGEIPDLYHSYLGLAALGVIGTEGTKDVDPVLCVSRETREKVEKIRERWKTDRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7J9</accession>
    <name>A0A6A7C7J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_255339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7J9"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118032" checksum="588442AB30F5F6B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7U9</accession>
    <name>A0A6A7C7U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7U9"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="35354" checksum="717C90EA27C63D59" modified="2020-06-17" version="1">MILPRVRICLGKILYGNKAGKNGVRISRDRMIKYPCHETELEALRFVADHTSMPAPRVLEKFYLKGKLGVVMEYFPNTQSLDSCWEELDGVQKREIVKQLSNHLEQMRALPPDDDYKIASTYGRACYDFRVATDTFGPFEDSVEFHEALVNDRVKSNPVIQDFIYNEYKARFTHGNLDVINILVNKKTHQFVALIDWKGAGWFPDYWEYTKMHFHAIYCVEFVELMKEVIERYDKELEIEEYLWRIEKKPLDPATRAADEVVQSIETDSVAETVIVTPQVSPLDNDEEVGCIYDPVCALLHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C823</accession>
    <name>A0A6A7C823_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C823"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025437586" description="Sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="24918" checksum="22A634C126A9A3D2" modified="2020-06-17" version="1">MTRRFFVPSLVFAVVLVLVLFTSVYRHDPPHHDDLPARRTLKTPIRAEAHSIKSQPLAAQPIEAQPKAQLPLHSTPPLAAAISLHPTDNLLTGTTIMPKLGNATAKAELGRAAWRLFHTIMARFPDKPTPDEREALHSYIHLFVRLYPCGECAEHFREIVRRFPPQVSSRSAAATWACHVHNQVNLRLGKEVFDCSNIGEFYDCGCAEGEEENEEEKGKGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C866</accession>
    <name>A0A6A7C866_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C866"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="81" mass="8973" checksum="23E6D697405C8329" modified="2020-06-17" version="1">MTESIFEGTLKQILKQPGDYVEASEDVAVIKADRIDIGVFAPMAGTIKELLVSEQDTVIVSQDMICFEVGVQQRKLADEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8A8</accession>
    <name>A0A6A7C8A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_127094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8A8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="110" mass="12391" checksum="AD2C7855425364DA" modified="2020-06-17" version="1">MIQLGKVVFTHAIASSDFLRCSRGRRDYVKVSNRQQAILELRRAGKEWVTNANASGGVRGCRTNFQLEDMFIARRVRSIRFWGGAVHLTNLLIGFNVLGALKWATGQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8D0</accession>
    <name>A0A6A7C8D0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8D0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rab"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22427" checksum="7BFC81AA0D2332E1" modified="2020-06-17" version="1">MSYTHPLKKFKLVFLGEQSVGKTSLITRFMYDSFDSTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVTSAKTFQQTRKWIDDVRGERGNDVIIVLVGNKTDLGSEKREVSVAQGEEEAKRNGTMFVETSAKVGHNVKTLFKRIAQALPGGDAPQSESTTIDVNVHQAKPESEGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9D2</accession>
    <name>A0A6A7C9D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_50299</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9D2"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="289"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="498"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2864023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="683" mass="76616" checksum="E4A8CCB076252744" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I2</accession>
    <name>A0A6A7C9I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_50598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="111" mass="13144" checksum="917F32C270AB142F" modified="2020-06-17" version="1">MSGGGNMGGILRRCWRCNRHWARCLLCFCVYGRLGEELHARRRKPESIHDENCKWYSRIRCGWVSWSQSDLKSEARVVFYPACQGMIVNPNTIIVRYGYLYSWFSLNQQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9L8</accession>
    <name>A0A6A7C9L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_200185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9L8"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="17062" checksum="56B8F868CD7FFD28" modified="2020-06-17" version="1" fragment="single">CKCCPKKPQRFLTADELRAHEAQKPFACGFCSHRFKNRNEAERHQNSLHLRKHSWSCEAMAGPESAFWPSPAAAHNDLCGFCGKEFPLPPQWDVRTEHLNRKHKFKECNLGKKFFRADHFRQHLKHSHAGVNGKWTSVLENACVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA68</accession>
    <name>A0A6A7CA68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_202474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA68"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="138"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="38777" checksum="88DF2B20E5AE479D" modified="2020-06-17" version="1" fragment="single">KMSILHTESKDIDHYISRINHLEAITTHQDQALRSLQEMLPSLIVVSKSNDQLDIPEQFWQALQQRLSGEKNTSLWNDFVKSNTDRLEALKDNDGSAAKEEKLHVITSDAFRDVMNARFSELRKEFGSSLIEVEEKIAKALSQRMSAASLSHEQARELAQSRIIMNMQQSIHEKNFFSPALGAKADIYLTSRTAHRTPNAALERWAEAGDCWCAAASIYGDPKAQLAVTLPKRVVPREFVMEHVPTGEEDVIGSAPRDLEFWARAGKMTGDTDMRGLEGPYSAGCATTPPASQYICLGTGRYDVNGDNWVQRFGVASSNGFDKFIVRVVTNWGAPNTCLYRVRLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAD7</accession>
    <name>A0A6A7CAD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_254274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="661" mass="71993" checksum="314EA6022E25BED2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CAH9_9PEZI</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="51" mass="5673" checksum="B55F964DA6072739" modified="2020-06-17" version="1">MARGNQREKAREKNQKAQAAQKSKTTMSGAEQQREKDKVKAIMQAKQAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAJ4</accession>
    <name>A0A6A7CAJ4_9PEZI</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Lutzoni F."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="32305" checksum="6407C22FD19520CF" modified="2020-06-17" version="1">MDRGDVESIGAHCQMTFCHQLDFLPFKCESCKGTFCLDHRSESAHNCQSAGQWARRRAEEQRSGASPSPKPNILTHEQQCSEPSCKTLIHTARVTGVHCDKCRRDYCLKHRFPSDHGCANLAPLGAVPGSVKRSGAQNAKGLAALEKLRAWGAQKRQAAAQQAPKSIASRQILEATQMKKSAKGDPKIPPDKRIYLYVEASSDTVTSKVPKGTFFYSTDFTVGRVLDVAARELQVSNVNNRTDNIKDKLRVFHIEGGRLLGFNEKLGQTVQTGNTIVLLRGVNDGMAQTPDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAK0</accession>
    <name>A0A6A7CAK0_9PEZI</name>
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            <fullName evidence="10">UBX domain-containing protein</fullName>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="entry name" value="UBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
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        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34121" checksum="3999D3F167F560D0" modified="2020-06-17" version="1">MATDLEQLVDMGFEKERANLALKKSGNLTGALDWLEKNADTSLEDLEEEEAAAAQAGDTADGAQAQSFVCNDCGKKLRNMNMAQFHAEKTGHDDFSESTEELAPLTEEEKKKKLEAMRAALAQKKAKQSVEDKLAEKRNEEIRKKHTKENDEAKELLQRKQQIKEAQQKKKEKQEDAEAKKRIKARIEADKAERKRKAEEEKAKRENPASMDPGAGAPRPSAVAAVQKSSSTASEARLRLQTLSGNVMKTFPADTTLFEVAHALEQENGTRATTFTVNFPKRVYSREDFGQTLKEAGFVPSAALIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAU3</accession>
    <name>A0A6A7CAU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_254173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAU3"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="535" mass="59386" checksum="56BB04AD241DD3DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBC9</accession>
    <name>A0A6A7CBC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_4945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBC9"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39540" checksum="5474C107CDABD218" modified="2020-06-17" version="1">MVLVNLGHVCSHLQNASLARLGLTSVPYTKLHLSFSLLLLKQGFLSQVKLAGPSPPASCFPNALPDNRLVTSAPHRDQSPWSGEAALADLLAGKTVEELRTAGFDDDAIAFAERARTLSAEQLANDGWDKVASDFIIQHRDKSQEQLTSAGLDDEACKIALEGTKRLRRIEEMLRSQPLSDSYDRESLTHEDWRRLFRSALQKEGFDQQTLQYFAGPKQFATASRLEQEGTTISAMGLDITGQPVSPLPAQFRDRLAQEEEGVITQANRASRRLWLGLKYWEGRPVISKARLVSKPSKRIWLTSQELGAVVRGDHVGHVKGMGQVGEIMAISTDRGLLEARECVERKIGGQAMCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDB6</accession>
    <name>A0A6A7CDB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_267234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CDB6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="288" mass="32679" checksum="BB4D12DFDA014B36" modified="2020-06-17" version="1">MSKSPVISPKNTKGPSPSFVTAELGRARRARRLVPSTFAAVPVPKPDYQQLIPGTAQSKRRFRCLTIFLHKARTDLAQRFHYNIRKPYLPPDLKAKTPDTIALILALAHASRAYASRAKFYNDLRQVRLTRLKEAGKKDGRSKGEKAETIVRLNIPTPETEFEIVPENVYGLMVADVLKLSNMHSSLARLKARPVDIMEEFHELSEAERKGYRELVKGLDKFIPGDGEVEDMNPQHKQKNLQSNISLTHLGETIRNPRIALPLEEVDWKSMILHRETGLEQTLGRITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP44</accession>
    <name>A0A6A7BP44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_261065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006062">
        <property type="protein sequence ID" value="KAF2857156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP44"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="32773" checksum="D6E0B5E28C3AD57B" modified="2020-06-17" version="1">MAQNYGSNPYATGQQVEMQPVADANKILNDCRSVSQAIDQQEARLPELEKLQRGFVSGNGTSNAEIENLSADIMAGFRELAHRVRRIKSQPEADNPRNSSQVAALDRRIRQAIQAFQSSEAQFRREVNEQQRRQYLIVRPDATETELQQATEGGGNTQIFQQALLHADRRGQAQSTLRNVQQRHEAIQQIEQTMNELTLLFQQLDEMIVMQEPKIQQAEQQATAAKDNVESGNKEMDKGIKSARGARKKKWICLGICFLIIAIIVIIVCAYGATQGWFSHNKSTTGTSTTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQD9</accession>
    <name>A0A6A7BQD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_273231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006040">
        <property type="protein sequence ID" value="KAF2857501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQD9"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
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        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="394" mass="44650" checksum="605181D6D944FC04" modified="2020-06-17" version="1" fragment="single">MQNPNQGVAKPLQNHVHLISGHRFPNLPTISLEQVVRYLVDAPTIAKSMAPMAWHYVTCPPDGTLWLEWLPPEKMVANARYPSDGYVWGDQEMPYRQSINGYTLEIMDHTIGFRYGLEAMAQHARTRYHLLAKAPNVNAAPPDPSLWLVHYHPADQRRVLPSQQVPIPQAVQISLSERQWLESQGKLERKDFMLHDRSSWPMIYVPSQARAVQRGFGSTPGQRFPPQLVGGTVGPVTKRQRLSQSGELADTNIEDEENTTLGDFFDHLTARDVSLARYLQHHRWIEEVFSSPYASEQIVPMDLGLGLAGELRGLTEGILDPPASVSERERTAEPSEAQPFAISPAQLEEFIGRMQKHLEEGREDLERIKSEHSARMAQWKQPNALMQAAQKLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRV7</accession>
    <name>A0A6A7BRV7_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006044">
        <property type="protein sequence ID" value="KAF2857429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRV7"/>
    <dbReference type="OrthoDB" id="5392447at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="319" mass="36759" checksum="63ED9953E8C4AAFD" modified="2020-06-17" version="1">MVGLPGSNGNALTSAWFDKLKDCCEELPDLQEWLSQEVDVLKSFYFGEKNTEDAAYAITRPISTNPVPKVEYSYTPQLVALDSLWSIILSTLLACPENRVEDMFNLLDAISKIPDKMHKGEAKNPANNELLTWKGIPYFGAALHEFYYPEPGVAHDKYKDDPKELESERRTYLEMQDLTARIIAHGIFLPSYTDIVYIIRCLEQKDDAKDVGEPFFGIKFDFEIPAMAYRFRSYGKEIYRMVVKSDTVETGWTSQEEPEGVKKFDNGQQRWDFWKKRFTEMAENYDDENVRKAAKEILGYMADAEANDRKEPEKSVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY0</accession>
    <name>A0A6A7BRY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY0"/>
    <dbReference type="OrthoDB" id="3644822at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23360" checksum="81E512530884E4C8" modified="2020-06-17" version="1">MSPNDQTAISTLKGVAVGSALLSAGSILTTSLHLIPSLLHATSSKVGGEEPSRSGRLTPQPSHQGGGSSNDSLLTPGTTFPLSKASSSRSTSYRLAAEQFGIITQGGWKTQAPLQGVAALSAACLAVYYYRGMGNRAGVAKWSAATVALLAGGVIEGGWMAPLRHKLNRIGGLEAPVEPYEDAPIDHEEERGNTDQFLRLWDGFNFMRGVLVLVAGGVGMADLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS87</accession>
    <name>A0A6A7BS87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_260077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS87"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="13"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="615"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="853"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="963" mass="108286" checksum="73C8F1E816F63F43" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSD7</accession>
    <name>A0A6A7BSD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_143943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSD7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025571488" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10489" checksum="4FB4394C6421CDEC" modified="2020-06-17" version="1">MIVLIGLCVIGGRGAGPYANHMQGFLLCCCSGDETFGIGEELTFQRSLAVCTLSEPILEKIWNQTRDTYWSRIFSVLSLVSSLVWKSNRVLMLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSH0</accession>
    <name>A0A6A7BSH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">K470DRAFT_252875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSH0"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="65"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="234" mass="26459" checksum="F332E3DF3EBD9B4D" modified="2020-06-17" version="1">MSDARSRQLEPSKLGTKEYWDKVYSREVSNHQTDETDEGTVWFSESGAEEAISKLLSNVQVLKRESARFLDLGTGNGHLLFFLREDKDEDGGWKGEMIGVDYSEQSIQLAGQIAEQRGKSSVLFERWDLLQDEPRQEWMEGFDVVLDKGTFDAISLMASGATHPCERYRERVVPLIKSGGFLCITSCNWTKEELLTWLAPADKCLIFHAEAKYPTFSFGGMTGQSIVTLLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSH1</accession>
    <name>A0A6A7BSH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_260105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSH1"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="999" mass="109273" checksum="471736697C856FD4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK5</accession>
    <name>A0A6A7BSK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_296765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSK5"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="686"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="799" mass="88403" checksum="132AECD2239A8A45" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSM2</accession>
    <name>A0A6A7BSM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_260132</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSM2"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="253"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="478"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="667"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
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            <end position="1123"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2858133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135054" checksum="9E5BE631EA71F3D2" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7BSN0</accession>
    <name>A0A6A7BSN0_9PEZI</name>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_279093</name>
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    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
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        <property type="entry name" value="ARM-type_fold"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1091" mass="119970" checksum="ECED8DF6DA992813" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT57</accession>
    <name>A0A6A7BT57_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">K470DRAFT_259696</name>
    </gene>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="301" mass="33278" checksum="556878644855BD74" modified="2020-06-17" version="1">MKHYEATPYLLPGCKLGEAPFWDKDHNELRFVDIKAPAIHFVNLEKGPSSHRCVRLEDCITVTANVQGNTGDDEFAFAGRHGFGLMDRRTDKVRWIRRMWAADDPAGNGMRANDGAVDPHGRFFAGAMEDGPDPGNRGVLFCLHHDLGLTRIKERVRIPNGISWGHGYIFFTDSPTRTIVRAPYDVDRATVDWAASEPFYVSPQGCVPDGHAVDENGRLWVALYGAGKVVQLDESGQPTSTVSCSTRCVTCPAICGTRLFITSATEEEADKHPWSVKHQGGVFSVDIGLRPRTPNRFVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT75</accession>
    <name>A0A6A7BT75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_300820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BT75"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="8">
        <location>
            <begin position="84"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="522"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="719" mass="79423" checksum="1D8486D5FD72C23E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT98</accession>
    <name>A0A6A7BT98_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_266260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT98"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="438" mass="50364" checksum="475A70188ECD6A3E" modified="2020-06-17" version="1">MPSTSISTLRPLGFQLGDCGYCKEEGSSQRTPKSRTSYFLESTSLDPDVYQALLDRGWRRSGPYLYLPDLIRSCCPHYAIRIPVAEFKPRRDQRQALHRWNRFILGDKYLNEMKKKYPKTKEQKKATNESFDLVEIANLAQKSHLKPGLTPPEHQFETSLEPTDFTEEKYKLFHHYQRNVHHESETDISRDGFKRFLCNSPIHHYAPTPGHSKLGSYHYCFRLDGCLIAMSVIDLLPTSVSSVYFIYHTDFEKFSFGKLSALHEAKLCLEGGYKFYNMGYYIHSCPKMRYKADYNPQYVLDYATKDWTPLDDELKQYMSETRCVSISRERAKQAGKPLPEENYILLDPMEATTCYQSLFDLGMPGIMSLDEVLNQVDVGDVRFISKSVVQPTALKKMPFWELPELGDEFSLPMLVAEIVATIGSIAAKGVVIDLSGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTV2</accession>
    <name>A0A6A7BTV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_296452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTV2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="375" mass="41219" checksum="14431DA87F8D93A4" modified="2020-06-17" version="1">MSTSTKRSSAMQSTKHKKAYGVSDFLAQQDVDIFQSRRPVVDLNKPLPKLPHENMPARKLVVGQDSYLPKLTVPSSSRDNTNRTGSPSTQKPPLRPSRANGLVCTANFTPRRRGLTTQGGQINTPPKNPFSTPSKKAGANSKQHERINTTAVNTDVKPLGTPKTPSWYTPKGFRKMFTPSSKSSRQQEPRGSETPSRGPRSGKESARLSDKMRNLSQEVVRGVNIVRLDPNDRETFERRQSSNHSRTTLATSSRHDSHANNEQNALTAGKRDTPTPDAVAGSENPFTKIESYALHIGRAVDPFRRPGTSGSNMSMSFADAALPEAMEVCTHCGQPPKKYIHSGGLCDACHEVRQRTLPTSSKVLKSGKSKFKEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUG1</accession>
    <name>A0A6A7BUG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA/RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_193272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUG1"/>
    <dbReference type="OrthoDB" id="4488294at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="13374" checksum="3E47C5B95E383851" modified="2020-06-17" version="1" fragment="single">YAFAYLDDIMIHSSTQDDHFKHVALVKHTLAAALIHISSAISIFNQSQIKYLGYHVGHQTISPDTDHFALPSWPPPTRKVELQQFLGTINWFRPFIPRLASLAAPLCQLTGNTTFQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK3</accession>
    <name>A0A6A7BUK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2859016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUK3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="132" mass="14766" checksum="94B3F4371AF76BA0" modified="2020-06-17" version="1" fragment="single">MQCWVVKCGFQTIYRPRFLLKELGTAKSVALSEELDTTTPEEDQHGSFALCGFNPCAASKNAEEPQAHPLELFLIEGDITYTQPDACRPSSVPVMVHYGWLGDAHISFDVSTTSTVRPIWKQHPIRGELEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUS6</accession>
    <name>A0A6A7BUS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUS6"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="254" mass="29186" checksum="2905DB3768081453" modified="2020-06-17" version="1">MSLGQTMTKRSFFDIFWPAFEKAFTKENVLSAWRKTGIFPFDPEVVLSKLPAARPVAAQSSEELSTSKRQLRLKVGKISRRADPETRKVLQELSQSALNTAARLTLAEHRCFNLEKSLALERRMRKRKSRLMEQVRGMEGYGGALFVVTGVLQKVRELEQQQADAKEREEQEKAQRVRERAEAKALKAAETLRKRQERQAAKDARMAAKARKKAEVAARKSAAQYKDDDDDDDNDYVEEWQLRRSTRQAISKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVQ8</accession>
    <name>A0A6A7BVQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_271734</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVQ8"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
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        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="404"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2859294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="61900" checksum="525CA403340EBE59" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVR9</accession>
    <name>A0A6A7BVR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_219399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
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        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="413" mass="45678" checksum="64E1E0DC7F3A46A8" modified="2020-06-17" version="1">MDALLSAHEQVSANGLERGVDILDNLISLLESQKAQLLSQPATITVPKSMIQDPFNDALTSLNEELLKKNKALNAYGKALKDKSPNAASHPQTPYLPSPTDYQHCLIDRSIAVHLLREGKFDVAETFMAEAEDSLAAKRLSNYGEDVPMTDINALNDMWAAELFPTGTTSNLTSKFKEMYSIISALEKQDLVPAMSWAAAHSEILNLRKSDLQFHLVQLQFVKHYATGDAKFALEYARFAFPSFAGRYHEEVAALLGSLAFINSRPPAYLQNVLESVTYPSVVENFVTEFCASLNLPPSSPLYPTVAAGSLALPVLQKLASKMNQARSQWSTEDELPVETPMPDEKFRFHSIFVCPISKQQSTDKNPPTLLKCGHVLAQESVHQLSRNRASAKCPYCSADLGINDTRRVYIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVW7</accession>
    <name>A0A6A7BVW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_295842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVW7"/>
    <dbReference type="OrthoDB" id="885191at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="548" mass="61732" checksum="622BE58992ECA75A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVX9</accession>
    <name>A0A6A7BVX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_220731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVX9"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="8">
        <location>
            <begin position="250"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="854" mass="94580" checksum="0EA3E211BA2ACBA4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW80</accession>
    <name>A0A6A7BW80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peroxisomal long-chain fatty acid import protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_258943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
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            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX26"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="501" mass="54210" checksum="37F19623A667FB62" modified="2020-06-17" version="1">MSRRIDRREYRQQENGEEAPLLRPDGSTFLENVAAGIAARQRAALRKRAVAQLSFLWAIINCLGAGSIMAFSLYGPLFQKRLHYSQLQVNGVSIAAELAMYLPVPLFGIVCDRLGPATPSLFAGVLFGVGYAFAAMVYRAGPAAWPPQAMMAAFVPIGSATSCMYISAVTTCAKNFGRGRFKGLALALPIACFGLSGMWQAQVGVHLLYDILPEGEREVDVYRYFVFLAVFLSVIGCVGFSALRVEEDEQLIVQESTEYGTLVEEEEQSPKNADGLLNERTKNFLTDHTMWWLAAGFFLVTGPGEAFINNMGTVLDTLRPDNAGGAATHVSVVAATSTLARIATGTLTDLLAPTTDGRWEVSRVLFLIVFALIMSVGQVVLASGALQDKADLFWIVSASIGAGYGAVFSLVPIITSIVWGVENFGTNWGILATAPAVGATLWGLIYSAVYQRAAGPDGLCSGVRCYESTFWAMAASVWTACLLWLWAWRGVNGWRKREISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXB9</accession>
    <name>A0A6A7BXB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_101188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXB9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="16811" checksum="C9AD33CD6FFF5369" modified="2020-06-17" version="1">METSRPDRRITENISWAAEGDSTGCVNALTDLPCRILPAFPSALHLPDFGLEERVGWKRLGSFVFGWKTYVLQYLLCKRAYQTYSIALDTPSHESFAVNRYSMFLKSSIASASNSARPGIQGSPLIFEWQVFATIMTFCFSTDWIRHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXQ3</accession>
    <name>A0A6A7BXQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_219514</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXQ3"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger RING-type eukaryotic" evidence="18">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2859288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="412" mass="45739" checksum="87B88B8C04A2D480" modified="2020-06-17" version="1">MDPPDDTTPSIFEPLSAWQLSSLIPPSLRYILAVLTHRHPRCLLRILNNFDELYLILSLAIETHFLRTENSTFVENFYGLQREKLPSVFPIPRAGAAQTSDLPRALRLRKRDIQLSLLAEVFAPYLKRKLDESWEIHASPSARLVRTDEEYPSEGTGKQKFLWVYKLFLRRLYPSVNMAWFASKLVFQMSYLFGGRYASPGLWIAGLRLRRGVAEAPPAVETLGKGKGFTPGEGRSLLTPRVMAGAVAGGLKVLLPTAIFLLKFLEWWHASDFARVLSKKVNEGLELPPPVGRVEGGGKRDDVGRGNGAEKGDDAGKEVRNLEGVRILTVAVVEGGGSCPICLGVITAPTAAQSGHVYCYKCIYMWVEGNHPRQEMGEEGWGDEKWDSGKGRDAVTGRRVLGGTRGLRRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BY67_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="136" mass="14434" checksum="C14D0992B64EC845" modified="2020-06-17" version="1">MQPSVTKRDVMGSDCGSSSSASSTVASQHGSLDASSLSTSKRPSADNTYLTQPMMKQEDDGEEQIPSTRPLGHSQKWDAQDSGNSGLDRTGSGYQQDSSTLGNREDEYVAADPTRSTLSKVATDKVGDGDPARCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYB9</accession>
    <name>A0A6A7BYB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_217460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="246"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="321" mass="35695" checksum="DF0CE601072D373F" modified="2020-06-17" version="1">MARYNPEPTGAEEDDADYHEEADEDFVPDTAAASEGTSSSDEDDEEDGGETLAKPGSRKRKPAVDAELESGDEATIKQRAPRRKRVEDEDAEADSGGEGGKGGFVRTRAQRRFDKAQDSKKQQPQKGEVTVDVEKLWKELKSAPLGPLPPPTPALQDEVATPEDFVVIKRRIEYAGVVSEVEERVERDSQLAREHAAREEESAGQKDNRNHLHRPLKRPSMFEPNPTGAVKNVPPTKLRPRAPNRMDVVMAEAQAAEALKKRAEKMTTVQKSALDWKGYVDQQGLRAELDEYGKSKKGFLAREEFLGRADLAREGRRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYC0</accession>
    <name>A0A6A7BYC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_218661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYC0"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9233" checksum="A8EE9D106E521171" modified="2020-06-17" version="1">MGKVHGSLARAGKVRSQTPKVRFPLAVRRGDHRSDPKQAAVEKQEKKKVPKGRAKKRILYTRRFVNVTLTGGKRKMNPNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYC2</accession>
    <name>A0A6A7BYC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="36762" checksum="0B1BFB21462BC6D0" modified="2020-06-17" version="1">MDYSPPTSTRLRLSSTASKSKQHEQKESDVWNGYQSDEETVSRTGLEDDDSLEDILNDYSSISSLDRSPSPPPLAQAVQIHNGEGRRQVAQAITIVTGKAKVISVSKPSTPVSPVSMELPPSPPPPCLPPKIEGGLTPSFPPKAFTRQRLRPLSMTPSLAAAAANLNRALPKTPTTSSSSSSTATPGTKASSPTTIPSPTSTSGDSGSRFRLHKFSSSLTNVFGKNKDSMRSPRSVPSLQRVKPGDRPISSLGLPPDPNTIGLGSETPRTAKPQTKKLVPRGASERAPAIELPPCPEDYNPDGDELMVPVPLGQMHAASVSQTALSIGKKRGITNMGRRLSYATTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYC3</accession>
    <name>A0A6A7BYC3_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYC3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="20489" checksum="718C1924340BA172" modified="2020-06-17" version="1">MGSACARKSSRLSARDEIIHCILPVLMEVISTALKPILIASAADEANSQRTAHNCLSQNPDLHTHSPNTFPLPLPTSSLLFFQIVNLSNPNHNPGTSARHRFIHAPGGASKKTLRKTFLFPYLDYRQWGTRFRIITHCPSPPMDATMALTDTNGENEASTSCWSTGFKHFLPGPSSVKLRLNPGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYH8</accession>
    <name>A0A6A7BYH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_287093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
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            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
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            <end position="201"/>
        </location>
    </feature>
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            <end position="283"/>
        </location>
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        <location>
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            <end position="328"/>
        </location>
    </feature>
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            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="411"/>
        </location>
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            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="508" mass="54570" checksum="1582305D9EDFEBFF" modified="2020-06-17" version="1">MARRESLVADQDHLAALGIKQELKRNFSFLSMLGLAFAILNSWTALSASLSLALPSGGPISVIWGLITAGICNLCLAASLAEFLSAYPTAGGQYHWVAIISWKRWTKVLSWITGWINVFGWMSLVATGGLLGSQLILGIIAMYRPSFEAKRWQQFLIYIAYNVVATILNAFCNNLLPYVNKAAITWSICGFCVISITVLACTSSGEFTSGKIVYGQFLNTVGWPDGIAWLLGLLQGGLGLTGFDAVAHMIEEIPNASVLGPRVMIYCVCIGTFTGFVFLSSLLFVSGPLDSILESPAGPVGAIILHATGSRAGTVCLLMFPLICLLFATTSIMTTSSRMTYAFARDGGLPFSRILARVHPTLDVPLESLALTVLVVLIFGCIFLGSTSAFNAIVSASVVALSVSYGIPVLINMLRGRKMLPPHRPFRLSGPIAWTANFIGVIYVIITTVLFVFPPELPVTGENMNYCIVVFAVVLGVSVVQWWVDGRKNYVGPQQGVGGKAMEAEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYZ3</accession>
    <name>A0A6A7BYZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_258453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="157" mass="17362" checksum="29264874162DBC52" modified="2020-06-17" version="1">MELPIAPVNLVLLVLFSLLLYARFRPAQASPAILPPTPAATVFRIFTPPQLLEFDGRDGRPVYLAVRGKVFDVTPGRNFYGPGGPYENFAGRDASRGLACNSFSREMLTSDLNGPLDQLEDLGTEEMSSLRGWEERFDEKYLVVGKLVAVNNNAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_217541</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2860237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15957" checksum="8D91D9FC67DD8D41" modified="2020-06-17" version="1">MLISFLATLVSSARNFAGTPLELTNIAILDDGNTTLSFDVYNPDPLANTRATCGAIWETSSNAYPTVSYKACANSTFGWQMKEFHSLNTFSLNILHTFHDPSVGQPPYDVVTVFAEGDIASTTVPCDANGHSCKQADATVIKATVTAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZA1</accession>
    <name>A0A6A7BZA1_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
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        <name evidence="5" type="ORF">K470DRAFT_258377</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1932312at2759"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        <location>
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            <end position="177"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
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        <location>
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            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
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            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860039.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="676" mass="74552" checksum="6E7CCA98C2B12AF2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP9</accession>
    <name>A0A6A7BZP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHORYLASE"/>
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    </dbReference>
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    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2860447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="883" mass="100854" checksum="0CB71C6293194D3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZT1</accession>
    <name>A0A6A7BZT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_86609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="217" mass="24301" checksum="8B4539F826B12857" modified="2020-06-17" version="1">MSRDISALGFGSDIGPILFLQKHGSCNDWRNLRRHLQKYARCPRARRVQHESVLTSPDCGFTQTCIRCGECPRNRQHVRREYGLSSRQAYTAQTSSTIEVIDDITSSRSTKFSFRSLQGFASSGRELTGKLPRRSLLYRNFCCVEITPGLQSSLETSMDANNNARCRQPNHTSSQSQGLVNSPLAHRHASNPLTGVNGQSLFVDSSDTIETMESFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZT9</accession>
    <name>A0A6A7BZT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 17.8 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_276668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21698" checksum="0E159BC3AE1ADCF0" modified="2020-06-17" version="1">MRPLIKAPIARSICQSLLKLRITARSYTAEARSSTGDAHGNESLGRSFYIVLLLIPGAIGFYKFRHSDEANPITRYIAQTYETWGKKWNEQQSLYTEMLDRAGSDRVLFLNEPTAFRNTKAVRVRFPEQITAGAAWNVPAGHYANVDKVIEKYRDEAYVGNEEKLKNLRDNRIKGEMPFEKSGLPRNQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZV8</accession>
    <name>A0A6A7BZV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_70983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZV8"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="41114" checksum="86DA382FAFF4D33B" modified="2020-06-17" version="1">MPWRHRGRRQPFVFTNTPTFSTSSTLEYPNHSDETRPKSPDKQPLKQNEPKNIECVCCFETVSLSEVTHCNSGAKHPHCKTCIRRVMREAIYGQSWTRMVDHKREGLYCFSTTTDACTGHISSIAIHDSICEDDDQGKKIWTAFHHKCIKTMFFERNISTRECPFCSALHAIKPPEPPTKPSLLSRLPFLSSFHKKTQQQPQPQPQPQLPLLKPSTRRVEKFRCRNEACGKVSCLLCKSEWQKDHTCYVAQRSTLRHQLDEAASDLIKRICPRCNIAVVKESGCNTVTCSCNASFCFGCGKELKMGDYSCCRFEQEQDVKVRLEDARSRIVKEWKRERGTVASSLQMCGLRRRGAVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C033</accession>
    <name>A0A6A7C033_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_79937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C033"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="10716" checksum="C3AA8D1C56178D7D" modified="2020-06-17" version="1">MVRTKRICRAIVCWKKSLRKRFVYCSAWQSMAVGGAATVRQQHAHMLTAITRQGRIRYEGGKASVQAKRVNSAALTNYSPGFADVADRETAVARLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0C3</accession>
    <name>A0A6A7C0C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_270195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0C3"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17888" checksum="32F03B91A9F0C099" modified="2020-06-17" version="1">MKYECTPKDCKLRAEQWGDRPFAELVAHLKRGTLYSIGVQVILMSNRGYGISACRKFSLVQLIIEYIGRIVTEDECQRRRMLEEYQTSSSHYFMEFGRGLVINAMRSNMAYFNNHSCTLNAVAKKVTVNGRPRLGIFAGDDWNRWYVRIKMDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0H4</accession>
    <name>A0A6A7C0H4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_270720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0H4"/>
    <dbReference type="OrthoDB" id="4360910at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="106" mass="11627" checksum="67BEE981B0019861" modified="2020-06-17" version="1">MPSLTRGLFYDPWRADFGNVVSENYLSLYIPILDPKELGLNSELMPIPGASQPADLQHQTSLIILDEAPMQHKFDISAVNKTLRDILESEGRLFGGMLVVAGGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0K2</accession>
    <name>A0A6A7C0K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_270966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0K2"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <sequence length="331" mass="34532" checksum="739788FE1E2C23DE" modified="2020-06-17" version="1">MASGTATPPPTSTGSTKIDALKQTVQAAANPQQLSGFALYSRFAFAGAVCCSVTHGCLTPVDVVKTRIQLDPATYNRGLVGGFRQVIQKEGAGALLTGAGPTFAGYFLQGAFKFGGYEFFKQQSISLLGYETASQNRTAVYLASSALAEFFADIALCPLEATRIRLVSDPGFANGLMSGFGKIASQEGIGGFYSGFGPILFKQVPYTMAKFVVYEKVAEMVYNNWVDKSKASPGTNTAINLGSGLVAGFAAAIVSQPADTMLSKINKTKGLPGESTTSRLIKIAKELGLRGSFGGIGARLFMVGTLTAGQFAIYGDIKRAIGAVGGVEIAK</sequence>
</entry>
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    <accession>A0A6A7C0N7</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        </source>
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            <dbReference type="EMBL" id="KAF2860787.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75693" checksum="A22C40C24F462001" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A7C0N8</accession>
    <name>A0A6A7C0N8_9PEZI</name>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
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            <end position="460"/>
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            <end position="514"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="623" mass="71128" checksum="3247A835BF5EECAE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0R4</accession>
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        <submittedName>
            <fullName evidence="7">Putative TATA-box binding protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">K470DRAFT_246259</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="220" mass="24683" checksum="9C40BBD76D5ECDFD" modified="2020-06-17" version="1">MEKSHRKCLAEAKRALESLDPSKDLSAPYITNTTARVDLDVILDLHKVAQNVWNVEYNPKRFPAAILRLRNPPATALLFSTGIMNVMGCSSPKDNKLAARKFARSLQRIGYKVRLYKYELNNVVAACSLGVRLDLNKLNIGKYGAQTIYETELFPGMTFKIFDPKMTLVIFDNGNIVFTGAKSQEDIDRALDFIRPILISHVKVSSSADDTSRSRDSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0R7</accession>
    <name>A0A6A7C0R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2861090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="19885" checksum="6AE464E220908A1F" modified="2020-06-17" version="1">MNHADLANASKSTALPKMKHPNLMVAKTTVGPSSIIDRLLPPRRVARHARRLQASLSAGSTAANAAPLLTASTQPSAAALHAASRSPISMVITNGKQSIKKAMRRMLLFELYNAEIWRSTNALVKELLCQGIVSEQQLGVIKKDIPTWRGRALAYARDRLNTVGNGTALFEIVRALSGLDGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Y6</accession>
    <name>A0A6A7C0Y6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">K470DRAFT_45834</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="70" mass="8132" checksum="E776E141AE126B7E" modified="2020-06-17" version="1">MPPKQKPVCRWRCRGEINLHCQSCGLQTYTRSDMCEMCSAAPRGCVRPTLISPHLIKHRHHRHHPLSPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C131</accession>
    <name>A0A6A7C131_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_281733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="22959" checksum="A01C0D12069B8EDB" modified="2020-06-17" version="1">MAEHIAKVLLKRAHSPDTAATLFTENVLQRPLVLHPTVPVTKKVRGGRIAKRTGNKKRKPQPLSRGQIRKLGLHEIPKSKQKFGIYKPLNGLWEGYIREVLGIATGRTYIDTLSAGPLLLTADYHGALITVVKSTCPSRVGIRGIVVKDTMFTFEVVTKKDQLKVLPKEGSIFRVIIGECVVELNGDAFKCRAPDRAGRKFKGVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C143</accession>
    <name>A0A6A7C143_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PRMT5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_257363</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C143"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="254"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="16">
        <location>
            <begin position="327"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="15">
        <location>
            <begin position="597"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="17">
        <location>
            <begin position="768"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2861022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="947" mass="104339" checksum="6C3880983E3265F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L3</accession>
    <name>A0A6A7C1L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L3"/>
    <dbReference type="OrthoDB" id="5392397at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025621933" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21772" checksum="3298A7C0F8B6F04A" modified="2020-06-17" version="1">MFSSLLTFLACYATATLASPITPRQANATTPFCSGKSSGLYKPAEGAILSQYISDSECNNFEILYCSGQYFKTSSLDLSVWLSPRFSSSPYQAMRSGQLLAKNVKPDDKDSAAGYYSYRFNVSICPIEGEYRTGPYILSAYETYSGQPALPYVSKPTANISLQVTTSHWIIPFPARMYQWPPLAHRHVTNPDVNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T1</accession>
    <name>A0A6A7C1T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_36615</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1T1"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000079">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="275"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="504"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="12">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2861461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="62513" checksum="720D94D462F3BD89" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1X9</accession>
    <name>A0A6A7C1X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_246015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1X9"/>
    <dbReference type="OrthoDB" id="3888684at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025686689" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10874" checksum="399527D0DCF75DFB" modified="2020-06-17" version="1">MKFALNLFVIAFLTALALAAAPERQVIVSYPNDTPVSVLEQAKAAIVKAGGIIEHEYNIIKGFAAKAPAKALETVHTLGAKYNVLIEDDQVVHTNDDDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Y9</accession>
    <name>A0A6A7C1Y9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_270355</name>
    </gene>
    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="421226at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CNG_cation_channel"/>
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        <property type="entry name" value="cNMP-bd_CS"/>
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        <property type="entry name" value="cNMP-bd_dom"/>
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        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="EMBL" id="KAF2861634.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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</entry>
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            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
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        </recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
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    <dbReference type="EMBL" id="MU005970">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="411" mass="44661" checksum="B8D31D8A659B988D" modified="2020-06-17" version="1">MSDLDKAIAQLRACRPVPEAQVRIICNKARELLLEEANVVLVDAPVTICGDIHGQFHDLMELFRVGGEVPDTSYLFMGDFVDRGFYSLETFLLLLSLKVRYPDRITLIRGNHESRQITTVYGFYDECLRKYGSPNVWRYCCEVFDYLALGALVLGAGTGLPPLDGAEADGPVDESVEIEVLDANAHCLHRYSRNGPDMAPDVPLSSSPSSSPDRLGAPGTGATASAGGSVSSNSGAVLCVHGGLSPLIETVDMIRLLDRKQEVPHEGAMCDLLWSDPDDIDKWGLSPRGAGFLFGPSIVRCFNQRNDLGLICRAHQLVMEGFKEMFDSTIVTVWSAPNYCYRCGNVAAILDLGPDASNAGYTPASNGDPSRAPAIRGDLRPAPGRRYRLFSAAPQDSRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C376</accession>
    <name>A0A6A7C376_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_269443</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C376"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="316"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="546"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2861914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="609" mass="68306" checksum="DF232062759CAD02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3J6</accession>
    <name>A0A6A7C3J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3J6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="7514" checksum="FBB493453E375960" modified="2020-06-17" version="1">MWFLPKPRTALLAKQQTELGKKLNGLARHQIKAEELEHYNEIIRRFELARNSLVTPEGARCVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y4</accession>
    <name>A0A6A7C3Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha beta hydrolase fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_269497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Y4"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="32922" checksum="A5A346FFBAD1B9EE" modified="2020-06-17" version="1">MLRRAIWSSQWKNIRLFTTSSTKLPNGITLSYDLHPPAAASPQKPAIVILHGLFGSKANNKTISRVLARDLGQEVYALDLRNHGASSHSPEHDYSHLAMDVELFLQEHGLSDIVLIGHSMGAKTAMTVALRHKVPIGALIPVDNAPVDAALKGNFGQYVQAMRRIADANLLSRSDADAILKEYEGSLGIRQFLLTNLIRDEDNNQTLHWRIPVSVLGKSLNNMADFPFKNPEAVQYNGPTLIVRGTQSPYVADEMLPVVGRFFPKFELADIDCGHWVISEKPQDFRRVVVDWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C406</accession>
    <name>A0A6A7C406_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_214941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C406"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="540" mass="59197" checksum="9A6C77AEB90A815A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C446</accession>
    <name>A0A6A7C446_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C446"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14564" checksum="748B2521084CA657" modified="2020-06-17" version="1">MCAVQTWAFTLGTFYASQGRLSGWNQSLVELWCSLSELSNLIYDPISHLGDWSEKVISAARELLKGLVTIFGFQIISNKNKRYVLFHIPLLARLYGPVIGASAQRPESGNKNVPAIVRHTSMHSTSRDVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4B1</accession>
    <name>A0A6A7C4B1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_256926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4B1"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="347"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="546" mass="60400" checksum="53FEF027F498EA4D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Q9</accession>
    <name>A0A6A7C4Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_202833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Q9"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="43013" checksum="C4E69BC4DEADABF7" modified="2020-06-17" version="1" fragment="single">MADVDEDAIPKSAPIDDVEDEIQDFRFLANLSNNCAKIPKRGEKDFEPHETNLQSQTLAASRQAMYDALSARRIHAPKSHNVATYHPATNMAYTINPKGPLFVKIGKVLAAKEDPFGDQGLRGQRVWLLPEEVLYLIDRGTVDVRWPTSEDKEEDEEGLVMSVQGAYATFLGSDVARTGHLTMDRYTVYSNLKRAGYTVMRAPSWSGMKSISRPSQHTFEVGLSCARKAWRSLWKENDREPLVGPGIFRNYTDVYRRLALIEWYDPTRSDHVSSSDCSMHVAFHVWKPGSTRFKKSDPGSPDYRIVVVDGRETTLPSLEELDTLMSTLPDDWPRDDAQLHMKLKHGYRNVVLAVVDQGVVSYLTWADAAFGKEKLYERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C500</accession>
    <name>A0A6A7C500_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfite reductase flavo protein alpha-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_280903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C500"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="212"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="669" mass="74482" checksum="FF8BCEDD85F91521" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C509</accession>
    <name>A0A6A7C509_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_262880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C509"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025587296" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28964" checksum="1FBFA0E05C0143E3" modified="2020-06-17" version="1">MHLPSILTLLTFLVAFTSAAVQAPGKAAGQPARHTPSQGPGPATPKTGGHASGKAKPPKRKRFRIRFEKYSLHGCSGDENDGAHNLGTKQCKSFKYHAGFGSLVTIPLQPPMPHRRCSLIIYAQRGCKGAKWISRDISVGGHCLNVQGRSVKVECTLKDLPVPHMIMDGQGELQIITTPPAYDATVIWNKRSVEPEVSAATTVPRVPQGLDPSKEEGWVEGEDDGDDGDEDDDDDEEDGKDNEEWDEEGDADEGEVEENIQQSQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C528</accession>
    <name>A0A6A7C528_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C528"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="338" mass="38465" checksum="DD3AF6FACED5D3C7" modified="2020-06-17" version="1">MSEAAALKQPIMGDTAMEDATKVEHTLGGAYDPPPIPTLDRWIEGLMQCKQLSEEEVRRLCEKAREILQDESNVQPVKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYFSVETVTLLVALKIRYPSRITILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDFLPLTALIDNQIFCLHGGLSPSIDTLDNIRQLNRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C579</accession>
    <name>A0A6A7C579_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_268702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C579"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="356" mass="39781" checksum="9BFAD60FD56F4261" modified="2020-06-17" version="1">MALHRGLQSAIFYYLSCAPCAEARYRRKRKEEAKIDRANRERLEAEYPDCYRHPSPSSTNPHWASEIAAGPTGVTRGKRKPPGSNRREASSNENRAWPGNGAAEIIMPERVRTRDSYRHPPINDWHPATVTKVHSREDVAWLTEPMPTADVMSGKTPPSTRAPTSASNRSKMSTVPTLSLTLPTISLSPSPDLSTDAGLQAPRRSFGEAMQERKTRRQAPDPVKPVQDPYTKTYVATKSPTLYEDSVTGISASSSTNNSLKEVRQIARKSTGNLKDDLDHHPGVAIVTSLVSCRRALMTPRTPKRPSPSPLPRDSDDDTDFLSLVDSWYTPDIDLDEWVHEFTKRDGISHRWSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C595</accession>
    <name>A0A6A7C595_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C595"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="140" mass="15684" checksum="1DE12384C60BE899" modified="2020-06-17" version="1">MKHVSSFDIVALEALLERLVVLEKVTLPELPSFAAAQIIIPLLQQECMRRLIISPHICLHFLASLARTPKWSLSEAEAGKLHCSLGYLKLTISRPFPTLFTAIGALQTLRYLISKPNTSRTHRPIFWMAIHVPASASYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5D8</accession>
    <name>A0A6A7C5D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_243214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5D8"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="14">
        <location>
            <begin position="117"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="767"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="856"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1262" mass="134409" checksum="BCACA1C4F0D3B9D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5K3</accession>
    <name>A0A6A7C5K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_17979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5K3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48295" checksum="FB4F5B9CE9215667" modified="2020-06-17" version="1">MEVAPPSYARLVHPDPWSLIAPYLLQPTLLHAILVNRRLHDVLTRHLWGRPLIPNIEKLNIFLQILPTVRQVVREKTHTLYLPAADPYSLEENLFKLWLKSVLTYLPNLQSLLLPPDSPHLDHTVLVLGSIPNRLRYLSLPQNQNLTEQSLATFLPLCSDLLYLNLPHTPTARSIPPILAHLHHLQILNLSSTGLTDNSIPPLCQSIGHRLRSLNLNNNHITDRGASLLLTHSLTTRYNTIPLPSSFEETLSHALTTSPLPPLEIETSPSVGITHLSLASTLITPQFAEHLISSSALQALDLGSLAIFLDGTGVNTLRIGYRSRVGTLRGVGRLVLTSIPSRTLSGEVVGMLCDFLEGARGSGLRELVLEVVASRDSVTGEEVSEGLVGRARGDFTFFEMEEKEVDTIEGVRRYRKRGKGWEGRVVVQYLRGNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6G7</accession>
    <name>A0A6A7C6G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_163450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6G7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="232" mass="26146" checksum="BFA30CA172EF338A" modified="2020-06-17" version="1">MTRAGRKVPENCRGPMIQKQLCPNHEHPVFITTIVISSTQDLFRNTAKTRCRIGWEQGSYFINTIEDSSSLQNLLTTLKLTRHCMGSLPSSTMRYNPICLDFNKLPTSTSTGGKIYFFDSHDIFETILSPEELGMKMHKGFGHVVDQAVQPWQDTMRSSEGQPILPSNFLKYPCNSTGCACRGNSLAELHSPSAQTSLTAPRRRVIHWPPSFSSTLPAFFCDRRSIRRASCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6H0</accession>
    <name>A0A6A7C6H0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_154592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6H0"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41385" checksum="94995298A35100C9" modified="2020-06-17" version="1">MPATRSSARQASAKKDDESASLTHGVKRQADESSPKAQRPAKAPKEQATLEQMMPNDEAQNEGGTGKKEADADRDVSGKDESGKEDTKEAAIEEDAKREKAQPENEMEKGIIYFFTRGRVGVEDPESTQDLQRSFFVLRPLAAGGKITDGAVQDVGNNRLFALPKKVWPKSGKDRFLTFVEKSGVSMDSLREEFFTGSDYDTKTVGTRHTPGASPLGEGVYSITWTGSGRATTHLAYMLTIPKELGEVQTDVGLAKHGSFVLSTKNPKSSGPANAQLPEGADYPQEVMDEFGSRGWLPTQPKHLDYPNAQILLIGESSGPDALEAAKHDQNDTSIETPLEELQKLEEENQLRVEHLKGDDTVFEDLGASGKDYPLKSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6T8</accession>
    <name>A0A6A7C6T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_195939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6T8"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="165" mass="18148" checksum="3040EDC9A7E4F2F6" modified="2020-06-17" version="1" fragment="single">CPFCAICAAFSPTPAHNSVPDEAAANRAVEEKNCYVVLATPRVVAFLDIMPLAPGHVLVCPRQHLARISDVDGATASELGAWLPVISRAVCKTTGVTDWNVVQNNGRWAAQVVDHVHTHVIPRYRDPGGAGRSWVMFGRGQRNELDEQEGRDMAARLRREIREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Y1</accession>
    <name>A0A6A7C6Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_268566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Y1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="234" mass="26043" checksum="DEB1D66CA10130B9" modified="2020-06-17" version="1">MNVHKSERHIAAHAIAHELTLQALIRDKVTLPNSPQPVTAAAGRVPMLAKNIPSFPHSRSSTTAAKRVSFLPPPQIDSLRRAEPMKEVVRTPYPFSPSLSVPSDDGRVTVSVRRRRRKGERSFPFPTPRNEKEAKEDADDEKFFLTPWKEYKALAGVWPTFGARRLFAGEFYPSLQQDKGDVLKHLGRPALAKEKRENAAWATGSKKQGALDEQPATPGSGDTTLRGHRRLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C714</accession>
    <name>A0A6A7C714_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_241922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C714"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="100"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="11">
        <location>
            <begin position="497"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="63173" checksum="589BAAA58B5A2D3F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A2</accession>
    <name>A0A6A7C7A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_198192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7A2"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10733" checksum="2C85874767DCA32B" modified="2020-06-17" version="1" fragment="single">AAKRVAFRAPLEEIIQTAKYTMAHYDLACSEPRLSAARQEEGEAHKAALRRSSKADDDEPNDDSNDDDEHNIMYPVTPVAGRRKRHRQWRWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7L3</accession>
    <name>A0A6A7C7L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7L3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="12737" checksum="1DE74AC3401A7AD3" modified="2020-06-17" version="1">MHGRRKNAGNDSTSSGRRLADGSRLGSSLGGGTSHILPTPAIITRVALQQVGYWLLGPVLLVGPFISSAVFARLSYVHPPPWWPSETWTSECACPSRRTLLPRASVTGRKQQRDGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7S3</accession>
    <name>A0A6A7C7S3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF6540"/>
    </dbReference>
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        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15288" checksum="E47CB39A17B20FE6" modified="2020-06-17" version="1">MASSNVLETHVAIYLPSDSRDPHHWALFPQGHGKDVIWQIVDDGDRYTIDTPLHNKHPQRSSRVKELVLVGTVPLKYHDAALETIQKTTPNNTSKTWNCQSWVVEVLDNLASRGILTWKKGARNDLLGLRENWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C807</accession>
    <name>A0A6A7C807_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_226859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="18009" checksum="829F4581E441D424" modified="2020-06-17" version="1">MTDDWKTQYLQSLTHRDEREQKYSKYINSYTLLADRQPTLTLSPASNPAARTAHLQLAHDALTSKHTSTQAQLESLKKQTVLLQRRLRDREEEAAEKSKLVQNAHDEMVAMNLQLSMAEQKADKLEKENKELVDRWVKRMEVEVEEMNERSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C890</accession>
    <name>A0A6A7C890_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_297959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C890"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="24973" checksum="76D9E47FA4E1CE51" modified="2020-06-17" version="1">MSNISVTICGQGGCGKSSITLRFVCNQWDQGYDPTIEDRYTVVRTVDGVTYTLNLTDTAGQEEYRELWRLSRVQSDAFLLVYDITQPGSLEALELFNQTVEAQCQAAMDLGHVVPVCLVVGNKSDLESTRRVPIQDGFVWAHARGYGFVEASARTNSNIEQIFTSLVRNLLTCLARRKIKDKALGLPNEGMPTRYLLANVWDPMGIPEEPEQQPFRFQHLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C893</accession>
    <name>A0A6A7C893_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_255165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10264728at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="197" mass="23159" checksum="E43CBD0806AFB010" modified="2020-06-17" version="1">MPALIRPMTPLDLLHFNHCNIDHLTETYNVDFYLEYFTRWPQLCKVIEGPNKRIDAYILGKLESSPYPEPEGVPYDPSLKHYMKKYPNYLPWHAHITCLTVSPEARRMGYATLLSTALEKVGDEEECWFVDLFVRVENYQAIGLYKKLGYSVYRRIKDYYSDGQDAFDMRKSLKRDKKNKTVRANGENVVVSCDKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C9</accession>
    <name>A0A6A7C8C9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_254643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8C9"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="309"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="606"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1278" mass="144099" checksum="3B5A37C4F26A87ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8I7</accession>
    <name>A0A6A7C8I7_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_193336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020472">
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="714"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="756"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="798"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="873" mass="97114" checksum="CDD14FC7F9B2FD89" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C975</accession>
    <name>A0A6A7C975_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_209629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C975"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="408" mass="45263" checksum="643B118DB0C90EAB" modified="2020-06-17" version="1">MDKDGSQHVEVHEAPLAGALALATMFSQCVEAFGLVHTGSSAHEERLLLVKLGLQQARLLIWGDIVGVTSPPSTVTNRVVPRHPSATYPDINEPTFFVRRDPRLDDPDVRQKIEATLGSIFDRTLGSGQTRNEMMSLYGLRAPKKPDIFREPAVDTNRLEAFRERFGLLQQVAEEYAHLGPPRNNSLMMNSWIIANTARFDKFISLIRDAVDSLVDLMGVKEAVDRATRMDIRALGWHVAPDWYRMDADRKKLELLKEVAAVDHPEHLDAVNAAAEQLQAYHVEHFKGGSGSSKSQKATSSHASGSNSSGKKGFLGLWKKKPSTNNVNEELEPQRSKSDAGLQHPGSQDMSVLEPIRSKSLGDILHPDPDEAREQPQGPKWEALPSGIIVRHDQYKGLARTDTKDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA50</accession>
    <name>A0A6A7CA50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_1210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA50"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="38213" checksum="28284E32E42DAA37" modified="2020-06-17" version="1">MATTNQVWYHNITLDLLVQICQRSVFHPFIAWLVPLCQRAVGASYTSFEVRLTCAYAAAVTLAWILGSVNQRIAYGAPRQPVPGDDVVVITGGANGLGKILADMYGMRGASVAVLDVQEPEERSEASKDVKYYLCDVGDAAAVTQAKEKIETDLGIPTILINNAGIVSGKALLDLTDGEIERTIRVNLLSHFHTIRAFLPGILKSECGGTVVTIASVLGKLGAARLSDYTAAKAGLIAMHTSLKAELESPVAPKEAERVRLILVTPGQMTTRLFCGVQTPSNFFGPVVEPVELANEIVRMTEAGKGGEISLPFYAQHIAWFHVLPVGLQILVRKVGGVDRAMEEFGRPNSIMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA92</accession>
    <name>A0A6A7CA92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_53216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA92"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="249" mass="28995" checksum="C686EA851BB70BFC" modified="2020-06-17" version="1">MPAADKDGLDSTTDDRRLHSRRLPSPESESDSVSTISTQSPSSEPRRREHRPRINSPSRQSKRLSDQEERGRSSCRRQTSHSPNHSRRSSLSLAGHSSCVSRERDAGRLGRSMRSRSGRRFRSREKNRRRDQRHESGERDIGKHSRSSYSRSRSPYRVRKRENDYRRRPGSPYGYRERRHVRSLPKQRSRSPPPKRAEDEGQAGITRCQGRSSRSPRQGRRRSPETKERSLSPYSKRVALTNAWRTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAS9</accession>
    <name>A0A6A7CAS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_208390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAS9"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="51"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="37249" checksum="B64E64296ADEBDFF" modified="2020-06-17" version="1">MRRKAGPIDSLKVYNKYAHIGAQAPADLVKAAAAAQSGSVQATPEQYEQSYLCPVQVGSNTLMLDFDTGSSDLWVFSTVTPSSVSSGHSLYNPSTSGKRLSGATWKISYGDGSGASGIVYSDKVTIGGVTATSQAVEAATSMSSSFASDPDNDGLVGLAFSTLNTVQPTQQKTFFDTVKSSLASALFTATLRHNAAGTYDFGFIDSSKYTGSLTYVTADNSQGFWGFTAGGYSVGSSKTVSGSIGSSIADTGTSLMYIPAAAARAYYKAVSGATLDSTQGGYTFPCSATLPAFNVQIGSQVFTVPGTLINYAPVGNGKCFGGIQPSTGQPVNIFGDVFLKAVFAVFDARSSTPKLGFAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAT6</accession>
    <name>A0A6A7CAT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_261655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAT6"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2864199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="333" mass="34856" checksum="A4D01FBC835D77F9" modified="2020-06-17" version="1">MESPIASNSGGGGVGGGDKSSARKKARCTRSRTGCLTCRQRKLKCDEVRPLCGQCRKSSRDCVPSDAVAFRHQQNPSLNGPKAIQDRRARVIAAEVASREQAAASRIQPQAAEFAQGAAGFKTGSSPVGTTMAAGPSSGPAVAQEAGPSDKKPAKKFYSCTETFADNAVWVKIPKNLTFISVQNPEELPDEWDLPPPAQAQDQQDLGAGTLAHTANANTSPATAPTAPTLASAHGGDTMDQQTLAALAQHANFEHERHALHGNLNPEISSIALPQAPGHVTSAPLTLPSPRNPTGGQAGPVQQRTFPEYGFDPLHEPAAEGVPHLDPRLQEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAV5</accession>
    <name>A0A6A7CAV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_254210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAV5"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="359" mass="40112" checksum="F64C70B72128D0C4" modified="2020-06-17" version="1">MHVSQRYLDLTKQKLELTRLPREPQSSRPIPDIGVTKSQLEPLIDHWLEEYDWRRQETYINEHLPQFRALISGVRLHFVHRRSQRPHAIPLLFIHGFPESFLSAERVIDALCDPIDEHRPAFHLIVPSIPGFGLSDPVPEEGNSVPTTAALFDTLMKSLGYGRYMVHGSGWAFNICRMLALAHQESCLAIHTVNPEVPAPRSPPAEGLQTMAYALCDSPPGLLAYILDAIRPLPPTSSTPTSPASSHSQAMSTDEPESWSPTAILNWTMVYWLSGPEVALRWVANSAALAASLWLNHVNVPLGITQFSTPVAPLQWAEAYHRLALLRHRPGTVRFPAWERPGQVVEDIRELAAVIGAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB42</accession>
    <name>A0A6A7CB42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_279686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="141" mass="15812" checksum="38B5981E1FE176C4" modified="2020-06-17" version="1">MVKMRTVIPWHSTAGKDSNETLTTDRGHALLWRCRSFSEGELFQNGDKAGKYRVQYVYANDKAYYFGTKHYKGGQKVGVNDNSGCDVMNEAERAAIPTTDKKGDSGSGRVFPWWFEGRLWCASLISLSLDGLGKPSFLVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR31</accession>
    <name>A0A6A7BR31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_160099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR31"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="55" mass="6132" checksum="C0620C15D9DCDE47" modified="2020-06-17" version="1">MSCPCFRLSLRPLRAAAHSHPREPATDDTLVTKEKPKSNGNLSEGCGTHHDQNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRP4</accession>
    <name>A0A6A7BRP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_222350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRP4"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF116">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="360" mass="40081" checksum="8032CF5B76E36AC4" modified="2020-06-17" version="1">MGSFKKDALTDYALQKVLKDAEPIFGTETNVSTIPTERWMSKYADDVPIVRMNIPGTHDSATWNYTLETQAALAPVSALLGLPQLDPTFYQCQSISLASMLSKGIRAFDLRYAFDATKSTLVFWHGSALLSETATVEDVLYAFYNWLDTHPSEALFLSFQLERDKNSTDTQKELHRILSSPVAKHYINSAVGVFGTLGEARGKITLLKRFVMDTIPNNGSLPGLDFSPPRWTDNSETPFVLEYSSSGRAWIEDYYQPRTAINSTASEDIQIKFDAVQKNLRSAAGGDHPNDFFWTFTSATKILNSPSLRPVDFAQGKDGAKGINEQLLTLLKELKGKRLGVVMMDFFHQPEGLVETLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS08</accession>
    <name>A0A6A7BS08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_252162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS08"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="101"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="472" mass="53565" checksum="510961ECF128AB8B" modified="2020-06-17" version="1">METHEPPHRYIENRGYIDLDPDPQPTHLSSDDDIDIDYFEDDFSHPIPNHLKRPHDPTIGSHQKPKINTHATPSDHLPSLTNLRLTDREAGLLPTQSTQKDKSNHSTTESVLDPRTRLILHKFLDRNVITELHGVLSTGKEANVYHAIQIAERSEGGGKTATHTSPSPMTKHLAVKVYKTRILTFRSRSAYTPSRGGTSLSMIQHWAEREVRHLKRLHAHSVPCPEPILLKSHIIVMSFIGNNGVAAPRLKDVDLTVEEWKGVYFQTLMLVKRMWMCRLVHADLSEWNLLYEGGRVVVIDLGQGVDRENANALGFLRNDLETVTSFFGRKGVQVRGERAVFGFVVEDGGDCSEDGMRVKLEGLEARGIGDEGFKDEFIPRRLNEVDGEVERGGIGNLLPKDEGGDEQEGESEDDEGEFVEREHKPRGKRFEDKEAKKQHKMLVKEEKREQRKHKMPKHVKKQLVSSTSRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS99</accession>
    <name>A0A6A7BS99_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_252258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="592" mass="62667" checksum="7A2C84AB476EDCD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA5</accession>
    <name>A0A6A7BSA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_252060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA5"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26579" checksum="51B98BB4475847C2" modified="2020-06-17" version="1">MSEHTQLFGSCFCERNQYRVVVPTSQASAAQVFFDNGAVSRVAQATPIAAWLRVPLDWYESMTVAHFPDESHSSIKRTFQTPGHADPQRPVRRQFCGYCGTHLTAWDEARDADSVDVTLGSLFSQSLDQLRKLHLYPDWEDDSDASSAEEGGQADRNTEMEVDVAESKQPRARHLLQGDGMPYFENLVQDSRLGRIKRQTGSQSLPDGRVVQWSFVEIGSDVEVESETTHKRLRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSB1</accession>
    <name>A0A6A7BSB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_238079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSB1"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23556" checksum="7E477259A890E2CB" modified="2020-06-17" version="1" fragment="single">MHDADFRQAEKDWRSFVTCLNEKVMELDDTIPELPLKDLIFRIYRDVRFSSDPTPYKPYFSAAWSRTGRKGSYAHYYVQIAAGGSFVGAGLWHPEAASLAALRNDIDQQPENIKNVLKDKDIVDAFFGGSKSPLKAFLKMNASNALKVKPKGYDADHKDIELLRLRNYTVIRKLEDDEVTGSEGLTRIAELLAGGKPLVTYLNLVVMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSG5</accession>
    <name>A0A6A7BSG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_222001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSG5"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12392" checksum="E564E19CA74D49AF" modified="2020-06-17" version="1">MANSVEANDPPREASTPPPTSNKEESPWFSSSNEETEQEEAPATTTPLSDAERATFIAQATALQENLRKLIDSIEAVKLEHEKLRGENKFLQSYIGELMSASKITASAGGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSL9</accession>
    <name>A0A6A7BSL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_206408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSL9"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8880" checksum="73E0984D66DA262A" modified="2020-06-17" version="1" fragment="single">LSGIQKDVLRLYRQCLRAARFKPALARPNFEAFARKEFEKHMALNRKDFATIEFQLRKGERQLETYKQPGVRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT40</accession>
    <name>A0A6A7BT40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative FRE ferric reductase-like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_222475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT40"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="314"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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</entry>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1318" mass="145247" checksum="D538FA2FAC04C5B0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUJ2</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72959" checksum="BC16AA825DADFEBA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV00</accession>
    <name>A0A6A7BV00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV00"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="10287" checksum="798573C2D7AB7EBC" modified="2020-06-17" version="1">MNAFDSTSCVGAYHIPLLYTHLSVNPPLAIAIFLWAVRGCHILASRWKIVSQVGRLEKDSEIVLSAKGCMGASAGAARGTLVQGVLLIQLYASRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV20</accession>
    <name>A0A6A7BV20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein DEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_259123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV20"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48026" checksum="CB4266A7108C8051" modified="2020-06-17" version="1">MSPTAARSPAPDTAQPSHVAAVVNGAVEDAADDQSSGLSEPEDDDGTAGHAINNDPGSPVHDLEVKTADTEPKKLDQLAVAEEHAEDPTEKPAEDPANSPTLVDGMENLNEVKTGQKRKRSIDHLSSPPRPHAEQSLDQDKPTQAASHNGGRKGKKGRQKGRKSAHNEVQTNQNEAEPDLLAGAAASFEQLMKQFVGFRRRIYDERLASMNEALSALSAPDCQHVEYQRQVVCVDARRERQVREAYAYYALRLQSIRRTTLGERAQLMCQYDQEVRDLRDRTLAELCRDSASLQRERRQQYQKDEQYLYKFPADRDAQLLRQAKYNHEVSVLSGMSKYVGFPAAPDVQGANDGQADEDMREINVTRRQQNSHPPGPFLAPMTAEERLAHEKYIEQNSWTRPQRPPSVLHSTPRLTHGALGPVAPGGRLWATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV29</accession>
    <name>A0A6A7BV29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_259430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV29"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="183"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
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            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
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            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="264"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="291"/>
        </location>
        <ligand>
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            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="449"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="455"/>
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        <ligand>
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            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2858827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="492" mass="54482" checksum="46702040A4222FCE" modified="2020-06-17" version="1">MSQQPPGDFGLIGLAVMGQNLILNAADHGFTVIAYNRTVSKVDRFLQHEAKGKSIIGAHSIEEFVKLLKKPRRIMLLVMAGKPVDDFIETLLKAGIEPGDIIIDGGNSHYPDTNRRTKYLASKHIRFVGSGVSGGEEGARWGPSIMPGGNEEAWPYIKDVLQSISAKSDGEPCCQWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDLMKRGFKMSDKQMGDTFAEWNKGVLDSFLIEITRDILYFNDDDGKPLVEKILDCAGQKGTGKWTAINALDMGQPVTLIGEAVFSRCLSSLKGERIDASKRLSGPEPDFKGDLKEALANLEQALYASKIISYAQGFMLMQAAAKEYNWKLQKPEIALMWRGGCIIRSVFLKDITKAYRANPDLENLLYDDFFNKAIHKAQPGWRDTVSKAVSWGIPTPAFATALAFYDGIRTKDLPANLLQAQRDYFGAHTFRIKPEYASQKYPEGKDIHVNWTGRGGDVSASTYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV69</accession>
    <name>A0A6A7BV69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6359816at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="113" mass="13032" checksum="AC39AFE29808762D" modified="2020-06-17" version="1">MLMHAKVFAAAVKYMVPSLKQAPIAKFKSAILNNWNHHSFGLVLKTMYTTTPDLEMDLRTIVVDTMMNREGMLDKECVENVIHEIPTLAYQLLKAWKLKVERDNQVDRNMPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV75</accession>
    <name>A0A6A7BV75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_272282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2530521at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="242" mass="24913" checksum="CA4640F157E6D276" modified="2020-06-17" version="1">MEFAPPSGPPPPRVPEGWKAVWNEQYKEWFYVNLYTKQSSWEKPTQPATPAGDHKPTGNEKMSDEEYARKLQEEENRRSQGPAGGAASGYYNQQAPPAYGQSPYGAQPSYGQQSYGAPQPVYDQQPQQAYGAQPAYGQAYGGQPATATKGGGFLGKLTGKLGGSGGMGGGMMGGGMGGQQAAYGAQPKRHGNMMPMLGVGAAGLLGGAMLGEAMDGGDDGYGDGGGYGGDDGGDFGGDFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVC2</accession>
    <name>A0A6A7BVC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="106"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2858785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="21621" checksum="7667C5A2912D0417" modified="2020-06-17" version="1">MRPQVFLIAPTKGLPASPYPLLHYSMALSFPDASSAHDLFSLNNWITQWVFRYGKTQPSHYHSRTHECMAVLSGKALIRFGGSNGQVLRAKAGDVFVIPAGVSHQTFDTVPEADFALLTPGEGRGIPGTEGEVRNALQSLTLDGFTMLGAYPTGGKWDFCTEEDEMDSEEIWKVPVPAKDPVVGVDQEGLVGLWTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVQ0</accession>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VMA21"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8217" checksum="6AD6AA9CD6B90901" modified="2020-06-17" version="1" fragment="single">SNISPAVPSPVIYKLLGFSLAMVTLPIASYFLTVNSLFQAGNSTWAGALAAVMANVVLVAYIVVAFRENAAEAIEKSR</sequence>
</entry>
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    <name>A0A6A7BVV0_9PEZI</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="48971" checksum="7026C07F02D0F368" modified="2020-06-17" version="1">MDQQKRRSTESSLIFSLQALLIRHETYIADSERERKAMVKRIDSLEEDKRALEETNSAAIKENSKLLDQLEAVNNAVILSDAKVSSLQATLKDTREEVAKLTQLAVRAERLELQLQDYEAEQAQWRSNLAASEEAEKAAVRRWRQAERMLGNMQDQIERVEREAKEESEAQAEAVRRAERKKAVETRVKSSGRTVSPLIRDILQDNTNLQVSVMELRNMLRSSHEEMESLRRQLQIRPPSPEPVSLKTEIKRAACQELHVHHHYHRGNQRSLRRKKKRPGGTAVQPVEPCVSTSTETSPSTLHPSLFDGEENSHQSRPTTPGSEAEAEKKGGNYTPVQLVLGATKATVSDACAFAKPSISKPGGISGVELLSSLPAKPLPAPQRDKTPAKKRNKSTTRPSGVNQSGPLPVLLPMPAPICAPMLQNLNTEELQRALIDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWA4</accession>
    <name>A0A6A7BWA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_249216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="24584" checksum="FADB9C24A6A13166" modified="2020-06-17" version="1">MALNVARNSLLRNAFAVKRSGLAGAAFTRGKATLPDLAYDYGALEPAISGKIMELHHNAHHKTYVTNYNAAQDKMSEALAQGDIATQIATQAAINFNGGGHVNHSLFWENLAPTSQGGGEPPSGSLSKAINETWGSVDTLKEKMNTALAGIQGSGWAWLVQDTQTGALSIRTYANQDAVVGQFRPLLGIDAWEHAYYLQYNNKKAEYFKNIWNVINWKAAEKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWW1</accession>
    <name>A0A6A7BWW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWW1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="644"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="518"/>
        </location>
    </feature>
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            <end position="603"/>
        </location>
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        <location>
            <begin position="604"/>
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        </location>
    </feature>
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        <location>
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            <end position="644"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114094" checksum="1CE385D1D5D73058" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21056" checksum="3C0B24115B3CE671" modified="2020-06-17" version="1">MLPTLLFGLLASSVPTLANVTGCKDPCMSYREASRVANNFQTLIANYSDALADRVLTVDFNDWSDSVTTLIDSGCSSPQPLGSVTFDSRDSFKKGQGSQPAIPFQILNLWYACDGPVVIRWRSTQEPEIITGNIVLETKRSGDYGEPWLIKTVYSEFNSGAWLVNLGVFKPTCNSTAQHNARRAAPMRIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Barry K."/>
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="18578" checksum="3E6176CFA131FEA6" modified="2020-06-17" version="1">MFTESHSDSVTCLGFYGTGLLSGGADGLVNVFDLTKGEDEDEALEWVGNVRGAVNRCVWMEGGRGVGVVTTDEKFNVYDLKGGGERDWGDVRGILGAKYCVGLGEWRGGSVLLYGDNSLGTLAMADVHHLRDGERVEFPGGHGEDVVRDFVLYDDRAYTCGEDGAVRLWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXP8</accession>
    <name>A0A6A7BXP8_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="10 11">
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXP8"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="427" mass="46774" checksum="49CD7743C4E54A56" modified="2020-06-17" version="1">MDASKGKEEEQDLYEVLQISRTASKSEIKRAYHKAALANHPDKVPQEERESAEIKFKSISRAYEILSDDNNRALYDQHGMAAFDKANAGFPGGAGPDLDDFLAQMFGQGGSMPGGPTGPRRHPKGRSEVQQYEVTLAELYKGKTTKFSSTKNVICDHCKGSGGKEKAKAKECDSCKGRGMTSRLRPVGPGLVTQETVPCSTCHGKGSFYVDKDKCKKCKGERTVKQKKLLELYIPRGSCEGDRIVLKGEADQTPEDDEPGDIIFTLVEVQHETFARAGPDLQADLNITLAEALTGFDRVVLTHLDGRGIKLHVTQPKGKVLRPGEVLRVRGEGMPIKKSELKGDLYFTVVIKFPEDGWLEDQAAVDAVRAVLPKDEIHAVDEEPEEVDEVAFEEGSMEDFGAGSGDPRGGAEWEDEDGAEGMQCQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXY0</accession>
    <name>A0A6A7BXY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_258745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXY0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14383" checksum="882BEF6931F36213" modified="2020-06-17" version="1" fragment="single">MKPPTRVRIIRPTIRRHAREDCERHLASAARKLALESERVDSTFVCRSSMTSAPESTRVVPLHHQSDHGEQSFLKVRVPNRWANMAITISQALSIRTLVKLSATPLYHPLTNYNSQANPRAITRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY17</accession>
    <name>A0A6A7BY17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_192727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY17"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19061" checksum="EFE1732A0986A6E6" modified="2020-06-17" version="1" fragment="single">CQIHPSAVVADKAQLIGSYPIEIGENAVIHPWARICATKGRVVIGRSCIVYEMTVIGHSDMDAPVQDQDVVLGEGVTVESRAVVQAKSIGNRTTIEVGAVIGHGAVVGQWCKISPLERIRRGEMVEDYKVVYGNGQWRINDSVKNNEGVRQAKHEAQSKSVKLMKKMVSNGAAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYC5</accession>
    <name>A0A6A7BYC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYC5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="509" mass="56168" checksum="8AF172E3B69AD6D7" modified="2020-06-17" version="1">MATIPPRRRPSRRGSMADMPKSLLQQIQTLEKEFIVGTAKLKEITEHFVAELTKGLSKEGGNIPMNPTWCMGFPTGEETGKYLALDMGGTNLRVCEVTLLEGSGEFDITQSKYKLPEELKTGNAEDLWGYIADCLEQFMEYHHGGEQFLHMPLGFTFSYPVTQLYINHGVLQRWTKGFDIDGVEGHNVVLPFEAALKSRGLPIKLTALINDTTGTLIASNYTDPEMKMGCIFGTGCNAAYMETCGNIPKLSDMKLDPNQEIAINCEWGAFDNELKVLPRTKYDVMIDQDSPRPGQQSFEKMVSGLYLGELWRLVLVDLHENQECNIFKGQDISALKKPYSLDASFLSDIENDPFENLQETDDLFVQKLNIKANKPELELCRRLAELIGTRSARLSACGVAAISKKKGYKTCHVGADGSVFNKYPHFKARGAQALKEILDWEKGRDGKPLGRGNDPIEILPAEDGSGVGAALIAALTLKRAKEGNVTGIDNPEAMLHVCNTTAAAPSGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYF5</accession>
    <name>A0A6A7BYF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_258588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2683"/>
            <end position="3241"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3485"/>
            <end position="3821"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3826"/>
            <end position="3858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1434"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3246"/>
            <end position="3311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1440"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3251"/>
            <end position="3273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3279"/>
            <end position="3297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3298"/>
            <end position="3311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3858" mass="435832" checksum="6CDAFEB3EB6E831D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM7</accession>
    <name>A0A6A7BYM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_73839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM7"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="50"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="38859" checksum="E221F2B4611AC020" modified="2020-06-17" version="1">MESFEQEGARTLLSEIGATEYSYASTSARVSVMVAGAIFTFLGLLTIFLRGLSLALRKRPLGYDDSVMIIAWLCSIGFMTSSFIAVRWGIGIRNDDAPRSWFENALKAIYVSEYFYYSSIYFIKLSILLMYLRLTQGVKTFFYRGTIAMGVFLTFTFVPTILVILLQCSPRSAYWDTTVNGQCIDFTAFFYTTSGLSIITDIFILLLPVHMLWNLNCSRRQKAGILATFLVAGLSTLASCIRLYAVKIYTLSDHPMQDNARIKTWSFVEINLGLVCGSAAALKPLFFTPESRKGKDDSQRGMKIRLTEMVDQEGTGEVETEGSSPTNLRGIIGIIERGDAQRPKDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM8</accession>
    <name>A0A6A7BYM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_247668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM8"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="32"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="434" mass="47180" checksum="ADAEF177017C92BF" modified="2020-06-17" version="1">MYKLALRRSLAPVLSVAKTPIRQLSIHEYRSAQLLESYGIGVPKGGVAHNGKEAEKVASELPTSDMVIKAQVLAGGRGKGHFDNGFKGGVRIVYSPREAGILADQMIGHKLITKQTGERGRICNSVFIVERKFARREFYLAILMDRATQGPVIVASSQGGMDIETVAKESPEAIITTKINIHEGVTDDVARKIAEQLGFSPECIEDAKDTIQKLYRVFWEKDATQIEINPLSETSDHEVLCMDAKLNFDDNAEFREKEVFSWRDISQEDPDEVKAAKSGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGSPANFLDVGGGATAEAIKEAFDLITSDPKVTAIFVNIFGGIVRCDAIANGLIQVVKQMNLRTPVIARLQGTNMEAAHKLINESGLKIFSIDDLQSAAEKSVQFSKIVKSARDIDVGVEFSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYT2</accession>
    <name>A0A6A7BYT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_282233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="253"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="447"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="624" mass="70177" checksum="9E05A89A6C6E52E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ38</accession>
    <name>A0A6A7BZ38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1226-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_232734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ38"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45535" checksum="612618E25CCC6FCC" modified="2020-06-17" version="1">MHESEEEAQESLHVEIKNFALQPVYIALSKPARRAYLTTFLLSFASVALFVAAVISYVLFYTSFVPRIGFSREVYLQFDHVYIPSDDKYAGPHPYGIASLRPDIVGVQEYDVSVELVLPRTCDNINAGNFMLELSMYAPAGSKPARNNAIHREMLSDALQPEALVVSRRPAILPFRSRLVDLAYRITGLQWYLLNWRQETDHLAINMFERLEFPKGWRNVPAALKLEVQSKPRLQIYSARVIFRARLKGLRWFMYNHRVMSALVFVGAFWATELVFASAAWALFHRAPAMTPGKRIKSESPAAKIKTELMDEPQLSDTERTFPTTSAQMPLRYTAASPVIKREDDDFQSEVALPLLDADDEDDYDELGKDSGLGTSMDSGYPSRKESVRKRKGRRGALERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZC8</accession>
    <name>A0A6A7BZC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZC8"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="312" mass="34779" checksum="0260A7D741399EFE" modified="2020-06-17" version="1">MPAISESDLEKDFTVPGRPSVLGCPFARPHNPSSHAASIWSRYNKEAACGDAQMRRGSLWRGSLVDKEFSTEEYADKEGEANEDPTATATAALCPMRFLDQHSPEEVASYFERHKHELPQSHTACVKRYRVDDPRVKELDEKYGNLVSMIKGLGEKHQDLLINGDGHQDIKRWAESVPLEEELKCPVSRVTQKGRNEAKGDEAKYPVSGMSPHRDDRNGKQETNEKKFPMRKTRSREAGNTTQEGDTTLREIRVGESPTRPWGISVPVEYLDGVGGVDEGNGNGNGKKLVFTGPVFIGYSPDDAIRVLREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZH5</accession>
    <name>A0A6A7BZH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_247113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZH5"/>
    <dbReference type="OrthoDB" id="5132737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="68"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="36738" checksum="FFCF45A2694D8BA3" modified="2020-06-17" version="1">MSEDKIQYVDAYYGDPAYASTLAMRGSYLTEHMLDIDQPIARLCQNLNSTPVDLPSVSLFDNRFYKITLHKLVDANEMRVMRDITQLLVPSAESLATCALEQEYEFLKKSTNQGWNRCRKLTNIRPQPDYAVGFKKTAFTSQQVQRIWPFLGAGCISPFKARDGMLFPFLACEVKGNGGFICAARCQNAHSMGIAVFGVVNLFRLLGEEETLHRKILAFSIAHDASYVSITGHYPVLSNGSWTVHSHMIFGRKLGAREEMTQIGTIGRWSSLTVVKNVYRYWAPDHLKMLRDALNRVPDIPDVFLKEEFQGYLNKSAELLYNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZN6</accession>
    <name>A0A6A7BZN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_248096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZN6"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF18">
        <property type="entry name" value="HEXITOL PHOSPHATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="27677" checksum="B9B74A2B1661996F" modified="2020-06-17" version="1">MGKVQYILLDCDNTLCQSERLAFEACADLTNQVLEKKNVSARYDTDSLLEDFVGHNFRNMLIGLQKKHNFTMTQEEVDDYVGRELATVTNKLAEKCVECPGVTQQLEWAKAQGYRMAVVSTSAKPRVVASLKKTNLLRFFGEDLVYSAATSLNPPSSKPDPAIYIHACKELGVKPEECLTVEDSKSGATAGMRANIPLIAYVGIYGIEEGKKKEQEMADLLTKECKAKVVMYDWKEFPACVKKIEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZV4</accession>
    <name>A0A6A7BZV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZV4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="7357" checksum="6268B7E2C7279B8D" modified="2020-06-17" version="1">MLVQSRSLTAAKLIVLPSTRTVIAVVIGGMGVSIDPNAAKVGTEHDGQGNGAGGTVAVAGTTTATGPESGVNPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C039</accession>
    <name>A0A6A7C039_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_216246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C039"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="258" mass="27473" checksum="F283902452E6A293" modified="2020-06-17" version="1">MTRFRPCIDLHSGAVKQIVGGTLSSNTAGLKTNFTSDQPAAHFAQLYRKYGLRGGHVIMLGPGNEAAARDALDAWPGELQVGGGINNNNATQWIAAGAGRVIVTSFLFPAGVFSLQRLLAVFQALGGDPSKLVIDLSCRRVGSGWRVAIDRWQTITEFEVTADSVKLLEPYCSEFLIHAADAEGLQAGIDQDLVSHLARICSIPVTYAGGGRGIQDLELVERLSGGRVDLTIGSALDIFGGSGVTLRQCCDWNTSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0H8</accession>
    <name>A0A6A7C0H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_46180</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0H8"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="874"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="439"/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
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        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="USP39"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
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        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00443">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="494" mass="56610" checksum="55BCD25D71EA7CAC" modified="2020-06-17" version="1">MPKRPSSGELSSPSPKKARLNSESLSESASPSANGAAEFNADLYSDLYLDTISRKNLDFDFEKQCSVTLTTVNIYACLVCGRYFSGRGRQTPAYLHALDLNHHVFINLSTKKIYILPDGYEVLNRSVEDIKYVVEPTYTPEDVRRLSASNPAVVDLWGREYIPGFMGINNIKSNDYVNVIVQILSHVTPIRDYFLLSNLTAKPAIIQTFASLIRKLWNKRAFKSHVSPHELIQTITSRSSKRFTLTAQNDPAEFLGWFLNTLHLSLGGHRSKPKTSLIQQTFQGRLRIESQHITPRADASDRLRFEDAEIDSKVVPFIILTLDLPPAPLFQDDAEGNLIPQVSLWSVLQKYNGITAQERANTRVRYRLLHPLPEYVIMHIKRFQRNKFLDETRNQTIVTFGTEGLDLAPLVEPQPVEVGRGREVYDLVGNVTYEGVKVRDDSVEGEQERKMWKVQVLEGEGKWWEMQDLWVERVDRELLAARESYIMVWRRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1J2</accession>
    <name>A0A6A7C1J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1J2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="225"/>
        </location>
    </feature>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="367" mass="40551" checksum="66D13FE41F7F75BF" modified="2020-06-17" version="1" fragment="single">HIDEGMLISRSAIVPRRYSRRTHPSADRKLPQAHPRVNSQLPAAAEREERARIALSQLQRESSPVSSTTAAHPGEIDFETQSTQSQSSSTVTAAPVAAGPMSVPYLGLITKTIQRNIPYSKMLKEHNKEDSGAMELCLRLSEQRSYLYISSLLNIRRYNSVKNSTFRTITLRNNVFEQYSVGHPRFSNPGEENFNLNSGSAASSSNNTAPGATDMRPQALPASIRPPPMSFGTGAAGRSVRARLLSKSAKLAKQSANPQVKAETVVKLGVLAQGLIDAQRETHKDTLTRQGQEAESNSAQLLEVAGRQGRNWVRNNFIFGSYEPRFWHCSHSLIFWAERLSHAELVNVDIINELPSSDIVTQPKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C226</accession>
    <name>A0A6A7C226_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_269857</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18469" checksum="99060F6F06ADA1B3" modified="2020-06-17" version="1">MPFSCTTIFKPHQRDPDAGDRVYRLRTRFAESGGGQALLATHIRSGRAVVIKTIPGLRDGRTPKEVLHRPLARLQQPPQALPKWNIVMECCTGDDLTDSILHWQQQSTHPLNAFAYHFVTEMASALGYLHHSILDITNPTAGRIRNYSPIIHRDIKPDNIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C285</accession>
    <name>A0A6A7C285_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_257389</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C285"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="194"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="487"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="668"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129067" checksum="9A383482F4D4D6DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3L2</accession>
    <name>A0A6A7C3L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_256155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3L2"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="482" mass="53473" checksum="AA3B6D79F3E32A6A" modified="2020-06-17" version="1">MSTNGYGKLPAGYSLPESHADLMHKSLVDTDAEIADIMQKEIKRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYNGNQFIDQIESMCQKRALETFHLDPEKWGVNVQSLSGSPANLQVYQAIMRPHDRLMGLDLPHGGHLSHGYQTPTKKISAVSTYFETFPYRVNLETGLIDYDELEKNALMYRPKVLVAGTSAYCREIDYKRMREIADKVGCYLMMDMAHISGLVAAGVNKSPFEYADIVTTTTHKSLRGPRAAMIFFRKGVRKTEMKGGKEVQVMYDLENPINFSVFPGHQGGPHNHTIAALAVALKQAQSPEFKQYQQQVIKNAKQLEKSFTNMGYTLVTGGTDNHMVLLDLKPLGLDGARVEAVLEEVNITCNKNTTPGDKSALTPCGIRIGAPAMTSRGMGEKDFDRIAGYIKRCIELTQDIQKSLPKDANKLKDFKATVSQGNSEELKKLKDDIAAWAGTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3X4</accession>
    <name>A0A6A7C3X4_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2314" mass="258821" checksum="4CB9F235266C50B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y7</accession>
    <name>A0A6A7C3Y7_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="182" mass="20841" checksum="20DF79032B94883F" modified="2020-06-17" version="1">MGSAENFSTQGTVRAAAIAMIILTTISFFGRFCGRLSSKQPRLQPEDVFISIAYIFFLGMCICYLVIVRKMYKISAVEVGSMAPYEGIIEDVHITVPVMLATTELLWAILWAVKFSFLFLYRKLMIRLPHYIRWWWAVFVFCLLVCLPNRISPEVPLPKSPQPPPTSHSANDETVMDRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C402</accession>
    <name>A0A6A7C402_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C402"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="562" mass="62034" checksum="51932D1C99AF8A00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C441</accession>
    <name>A0A6A7C441_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C441"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="715" mass="78985" checksum="57B6BE88FCB83C30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C462</accession>
    <name>A0A6A7C462_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_18206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C462"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14321" checksum="AA8750BCCF0C6E43" modified="2020-06-17" version="1">MTRCSYVNGQQYCTRSSTWSRWARWLVTGLIILAFLVFWFLCLCMTARRRRKAGQKAYYGTNWMAGNQQQQPQFQQSQPYYNNSAPPPNYNQTQGYYAGNAGNTGGMQPPQATYQPPAGPPPGHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C479</accession>
    <name>A0A6A7C479_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_256897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C479"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="298" mass="34431" checksum="69FF6382B8F308B4" modified="2020-06-17" version="1">MVLRHRSSSPDQEPESGYASASSTCNLPEVYFTKPHLKFINKQLSELEPEDVLKWCLTSLPQLWQTSAFGLTGLAIMDMISKLDFTIKPNIELIFLDTLYHFPQTLDLVERVKQRYPNLSIHTFKPEGCETTAEFEKTYGERLWEADEEKYDWVAKVEPAQRAYRELDVKAVITGRRRSQGGKRGDLDIIEVEEETGLIKVNPLANWTFKQVQTYIRENNVPTNDLLDQGYRSIGDWHSTQPVTESEDERAGRWRGRQKTECGIHNKRSRYAMFLQSQKEQQDPQQLLDGVSAGLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A1</accession>
    <name>A0A6A7C4A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_16164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="7588" checksum="024B5FD94C985255" modified="2020-06-17" version="1">MFCHARLNCRRTGPTFRQTSDTKRASGGWMIILFYQFFFGASLLCPIPIFHCKRLEVDESREKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4E2</accession>
    <name>A0A6A7C4E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
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        <property type="protein sequence ID" value="KAF2862896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M4"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="2">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="280" mass="31357" checksum="DB89D681849592C7" modified="2020-06-17" version="1">MAQSPKPAYPPTLRGSSQIYTPIANSPRKPLYSHTVPPRCGHAFTARRGEIIRISTPSGPQVCDLNLWSLTNPRERFWASRTRQLHSTHITTHDRLWSTLPYLRPMATILTDSLSTYGVDPRGGRVHDLLGTRCDPYISRIFNPGGKAYDFHCHSNLVRAVVPWGLNEGDVHDVVNLFQVTGLDERGRYWMGASPARMGDYIELVAEMDLLLAVSTCPGGDLSEWGWEMGGLRHCCRELGVEVFEVCDKEVLGGLEIWETGLVRYRGMHGMNIPKGEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5U7</accession>
    <name>A0A6A7C5U7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rad10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_255665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5U7"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="32496" checksum="74AD6137BE6531E8" modified="2020-06-17" version="1">MAVQPVVQPKPQALARPALANIIVSPRQKGNPVLNNIKSVAWEYGETPADYVLGVTTCALFLSLKYHRLHPEYIYTRIRGLQGKYALRIILVMVDIDNHEASLKELSKTSLINNVTLILCWSAAEGGRYLEQFKAFENSHPTGIQQHQSDAYPDRMVDFVTTPRSINKTDAVTLMAVFGSVRTAVNARSEEVSEITGWGNKKVQQWCNAVREPFRMRHAATRKNLAPAAGGSVAATQPVNNVGMGPTQRPVVPVIKPSEKDKPEVAPQPPKRKLDETDDINEGVLAALSKLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C662</accession>
    <name>A0A6A7C662_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C662"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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    </evidence>
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            <dbReference type="Pfam" id="PF12411"/>
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        <source>
            <dbReference type="EMBL" id="KAF2862495.1"/>
        </source>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
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    </protein>
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        <name evidence="10" type="ORF">K470DRAFT_281109</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 480.64</strain>
        </source>
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        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6R4"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="13723" checksum="946B58A50D9FD44B" modified="2020-06-17" version="1">MLYELIGVVRPGRGVKEIKEITKTAGSIVLEGGGVVRGISNWGTFLLPKPARKPGAIYDQGHYFILRFDSSAQTQHSVRRTLGLDPRMIRYSIVKLGSTLAQIKDVKGVAEWPVVMQERRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6V3</accession>
    <name>A0A6A7C6V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_255492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6V3"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="586"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110648" checksum="F51AD8D9355ACCE6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Z0</accession>
    <name>A0A6A7C6Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Z0"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="217" mass="23874" checksum="6C018526B35035EF" modified="2020-06-17" version="1">MASSHPSDTFEGVPRLSPMHRWLKRRRLDELQSPTDRVFEPPASPLTGEKMASENVKNVQTRNEKYASSFSQGSLAGAPAKKYAIVTCMDARLDPAAAFGIELGDAHVIRNAGGNAQDALRSLIISQNMLGTREVMLIKHTKCGMLTFENPDARKLVCEACGNDAVADDYDFQPFKDLDEGVKADVKMIKNCKALVDKSKVSGWVYEVETGKVRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C748</accession>
    <name>A0A6A7C748_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_280470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C748"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="15">
        <location>
            <begin position="681"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2863213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120388" checksum="77EC236D1319C03F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Z5</accession>
    <name>A0A6A7C7Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_289931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3053196at2759"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="148"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
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        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="183"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C847</accession>
    <name>A0A6A7C847_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_262052</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="16514" checksum="F06827B9522DFC46" modified="2020-06-17" version="1">MVEFERQRRTMDEDLLTMAQSPHKRALSASWLDYIISCDGGNILMKLGLGEGQTAEPRVLERKHDFLDLALGQSACCAKKSSNKRWKSKQGISSPVPLAKTRAESSSESDSAKSQNWPTKSGIAEKAVILATSKVLDRLPSPNSGLKDSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B4</accession>
    <name>A0A6A7C8B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_274249</name>
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    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="16437" checksum="203F01DF35DAA695" modified="2020-06-17" version="1">MSYRMSDSNTRVATLFARFAAIHTTISALEQRYAAIPAVDLTTPEAREMREMLWDGEQEGFTDISNLLATLEEMLRIYSAKRTMTEPDERFSHFLTLVELGKNMMEELLGIVEAIVAEYEDVMQDRIEQTVEDLADLMESEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B5</accession>
    <name>A0A6A7C8B5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">SAM and PH domain-containing protein</fullName>
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    </gene>
    <organism evidence="4 5">
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="466"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="68573" checksum="02D1182FCFBA2A50" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C1</accession>
    <name>A0A6A7C8C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2212170at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="172" mass="19524" checksum="192F5B2982FDCEB5" modified="2020-06-17" version="1">MPRMFSGTCACGRISVSCNEMPSRTTACHCVQCRKISGGPYQLYTDVSPESLTFLDNTTKQEIKGKLPLEWKDKALSFTNLSKAGERVFCIDCKSLIWMRYLSHEEFVGISVALIDESSVANEKVKEKLGVMKHMFGSQKAFWDHTSFKDGKEVVQRFSEGWEESISSWEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8K0</accession>
    <name>A0A6A7C8K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_210331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8K0"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32654" checksum="431A527A5991DA97" modified="2020-06-17" version="1">MDYQFLNFTHPSDAKAQVARRTVRSHVTRQQHQKEQALQAARRASSRQNQVSEPQPPPPPPVTQEAPLDARLWGTAPESREADGMRPQSYQQINPFQLYPREWHQSIAAIEEFYAHNLAIDIPDLDPATTASWLRTRLLPLMYTDKASLHAVMLLAAAHYTQAHGQNSHAVDILSLRGLAIAEINQALREGRQRATSDQLILAVAEMASYEAAFGSRDDANTHMRGLHRMVLMRGGLPSLGLNGFVERVLLWIDSNVCYLLNRNLYFNDLSATPRHPPPDAMKFLGRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8R8</accession>
    <name>A0A6A7C8R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_254275</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8R8"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2863966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="133" mass="14384" checksum="D6EB6F5D8916917E" modified="2020-06-17" version="1">MSHAHRQTILPTHIRQSSAQSSTLQARVNAKKAELENLRQLRDLSADLACQMQNLEAKLATLNSGTECLAAVLGNWHNVLRAIHMASLSVQKTAQEGGAGDVSLPQTLVRIPIHQAEAMQKELDAVEAASAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U0</accession>
    <name>A0A6A7C8U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1349-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_210107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U0"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21535" checksum="DCEA07FE70985AB2" modified="2020-06-17" version="1">MSHKLCHAANGATSPSEDPFTLTAYPKTDVWRPSDDSDVFNAPYVFAKLDPNKFTNMSVTVSADWKTLYDQGGLILAYGEQNPRQWIKAGIEFFEGHPMIGVVGTDRYSDWSLTPNPGKDHNKATLEFVREGTELWIYLVGENQKRQAVREVRWAFISPKSPLEVGCYAAKPTPDSDNATAGVKVTFEGFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U4</accession>
    <name>A0A6A7C8U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="413"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="483" mass="54087" checksum="D79C3622F4491BF4" modified="2020-06-17" version="1">MPSPMRIDSPFLVRRGEEYEANWTKMSRGAVRPKAVKRQPNNGMLPPDPATNVIKGFVMSGDESDRSTTSTPMLRPVNGGISLLKAQIDGLHLDKQGALSTGTSTPMSKGSTESDCAEFETYDVSLADFVSPNANDTSPLRAMGQGQVCRKMNVDDFGVLRCLGKGAFGTVHLVKQHDTGRLYAQKQFKKASLTVHKRLIEQTRTERAILESINRHPFVVKLYYAFHDKERLYLILQYAPGGELFHHLSSQRMFSVETAAFYMAEMVLALEHLHHNVRVIYRDLKPENCLLDADGHLLLTDFGLSKVALEGEETTHTIVGTIEYMAPEVFLNKGYDFAVDWWSLGAIGFDLMTGSPPFPGGNRAKIESNIVKAKLQLPKILGPDAQDLLTRLLRKDPRKRLHGPALKAHRFFRKIDWKKLERRELTPPIQPFVSDPELAENFDKEFTELPLSPVLTRDAVCDGDPFGGFSFVASSLLRDEFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8V1</accession>
    <name>A0A6A7C8V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_241250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8V1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863667.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="210" mass="22295" checksum="E56782ACA49E8508" modified="2020-06-17" version="1">MVRKHLVKVCGTRTAEAAETAILSGADLIGIICVPGRSRTVSPEDARESISGLYNAQRALLVGVFQNQPLDEVQRISSLYNVDVIQLHGSEPLDWAGEFDGKPVIKSFSADECNVSSTKQHIIPLIDSGAGGTGERVSLAAVKTLLTRNPDLNILLAGGLRADNVREVVEGVGPELKGQIIGVDASSGLETGGKQDLNKIRKFVETVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Y8</accession>
    <name>A0A6A7C8Y8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="461"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="572" mass="62486" checksum="3B16E306FFFDC9F4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C925</accession>
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        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_267916</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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            <end position="10"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="399" mass="45374" checksum="FA8FBC467EF45782" modified="2020-06-17" version="1">MAQRFSHESPMDFEFQNGTGPIDTQSPFARLGQRFPPGSSNKMSFNFDSPEKRPFHPTTTTPGKHQLPAFNSLFTTPRKVTNEMDDSSAGETPKSPEAQDDVSDATPEQKPLFRSNGRRDSWIYRLKSKLNSPGRGEIPRVDPTEGTEKRITKRRRREVDRKLSRRKRRRGSASTSSSDADGEDGVLRRPRRQGSHQNENWLSSTFTFIGRHPTVPHILSYYAQLAFNIFLLTAIAYLLYCFWSAVQGDVDKKSHEAMAEIMIEMAACAKQYKNNDCDKVSLPAMEAVCANWERCMNQDPSKLVGRAHVGARTFAEIYNSFVEPISWKAAGFTFAIVVAAFTLSNLAFVSFRRSEAMAYAPPPYYPPPPQQNQQRYDLPQQQQHWNMNIEGSPVRKIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C969</accession>
    <name>A0A6A7C969_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C969"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="50011" checksum="41731995CE4A87A6" modified="2020-06-17" version="1">MPHINVPKLPNKRSERLFYHELLKHHEPTLRKLLEHNIPNPTPELLQTYAKDYSATIYSLLVGFEPTHPMVVETKHTLAFIYAYLGRLNDAANLLRAVLEVMMEELLLDDVVVLDIKQHMATYVWFLDNKSRWVVEELDYVYGNYAAHYADTSIQVLEAAHALANAVASANWTTGAESYAGSAADDNSKGEAAKAAGAAKRSYVKAATAGVRKGDSFAGKEADATVAASNGDTKGDPSTSKNPHKGDTTTAPTADLPTDPLPLNLSPLPPAATTSLPSAATSDAKKNFTTSLTGLLAIYGNKHPYTLRVTIDYAIFCASHGLAHIALQLAKRALEAAEEQYGPNHILVCDASFAIGRALVISGDLKGAEVWFNKARGFGEGGALISERLHLGGETEGEDKGAEGPGDKGRRKKAEREGDDKDLFFESSEDETVKVKKKKKPKVKFSKQGGVVERKAYVRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C981</accession>
    <name>A0A6A7C981_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1977-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C981"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="349" mass="38773" checksum="2F61B1423024AE21" modified="2020-06-17" version="1">MSEKRTSHHDGSSSRTYTAEQKSAVLRVRKCEPTAFYAILDLEQVRTTCSESDIKKAYRKLSLLTHPDKNGYPGADEAFKMVGRAFQILSDADKRAKYDRWGGDPESRFGRGRSSGQDGPPPSPFSGFAQQRAGARGAMFEEEISPEELFRQFFGGGMGGMGGPFGGLGGGRGFAFNSFGGGPGIRIHQFGGDTPRRRPHNHADVQPQSLFSAIQSLLPLLLLFVVPLLSSLWSSNGGTGPSMRFDAAVPPHTLRHTSGRLNVPYWVDPSEVDGYSPRKWRELDQLAERKYISQLSSTCEEEQTERQRLWREAQGFLSIFPDQAKAERARRMPMPACEKLGELGYRVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9F1</accession>
    <name>A0A6A7C9F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9F1"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="19472" checksum="48AB6DFF62EAC49D" modified="2020-06-17" version="1">MLGRRFLALSRTRTVSTRPPWRCHRLNSTQTPAQKPTSRFKELSRKYGYAAVGVYLGLSVLDFPLCFLAVQWLGTDRIAQAEHAVVKAFWQLVGSVGLDMRSNKQEEAPSDVSEIEADVKSGKRDASIWTQLLLAYGVHKSLIFFRIPLTAAVTPKLVKFLRARGWNIGRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9K2</accession>
    <name>A0A6A7C9K2_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_196323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="44015at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:clathrin-coated pit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:clathrin-coated vesicle"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="531" mass="59644" checksum="EB632BD148A7C88C" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9L1</accession>
    <name>A0A6A7C9L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26863" checksum="AD309161F6D8D600" modified="2020-06-17" version="1">MNARWLTDVKTRIGKCITFGMSPVQIEQAGVLLHRVARDWRQLVAGREGFLVPFRQKVTWGDMDSMGHVNNVVYNKYAEAGRAVWIRKLGELDPGNAKAWRETLQPKGDGLILRSITTEYKFPMTWPDRVLVYHKLRNRPDTDTESFILDVLIVSERHQRAAARCIEDLVAYDYRTGAKRRLPLYMRRVFEQTWKMQESSRVEAERQIGELLDGVRQLEKSTWDRKGAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Z4</accession>
    <name>A0A6A7C9Z4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_268229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
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    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
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    </dbReference>
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        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
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        <property type="entry name" value="UMUC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="9">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="594"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="609"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="609" mass="68817" checksum="E9745B87DDD11F3B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA01</accession>
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            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_261572</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025524193" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="137"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="334"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="567" mass="61600" checksum="B27158F4BFC0673F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA31</accession>
    <name>A0A6A7CA31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_297682</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA31"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864288.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDW5</accession>
    <name>A0A6A7CDW5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <end position="208"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="24387" checksum="2789E4ADAEB93B17" modified="2020-06-17" version="1">MFLALLAPLALAAPINDLDIYLEPVNEKVIPNPANKLCATWTISQSNTTYAAPKCTSWVPGNGVDPIPGEWVVFETEACGIFCDEWTVASACEKDYATCYIKPSCVYGRWDGGINETGAEPAGLVKRVASMLGLGKRTENTTPAKKNEDEDSDEDSDDEGSDDEDEHKKVKRHEAEKVGEDCDENKHDPDSDSDSDSDDSDSDDEEEASPSASSSVVPSASSPARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNR4</accession>
    <name>A0A6A7BNR4_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Integral outer membrane protein TolC, efflux pump component</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">K470DRAFT_273589</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30026">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30026:SF20">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN TOLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56954">
        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857080.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="545" mass="57480" checksum="2BDABDB41ABBA26A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP46</accession>
    <name>A0A6A7BP46_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP46"/>
    <dbReference type="OrthoDB" id="3693885at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="9226" checksum="0776E9342A9C9CC7" modified="2020-06-17" version="1">MMMRLLEEAHAILMTKLRHMDIHRFWLRQEVQQHAVEVDWISPPTTWLSMGSQKLSLVCPIHPSAHLVDVQPSLPILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPS7</accession>
    <name>A0A6A7BPS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_223555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
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    <dbReference type="Proteomes" id="UP000799421">
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPK"/>
    </dbReference>
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        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
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        <location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU363090"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111928" checksum="DEA58A7871114215" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPW8</accession>
    <name>A0A6A7BPW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_266934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPW8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
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    <dbReference type="Pfam" id="PF00026">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
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    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006046">
        <property type="protein sequence ID" value="KAF2857402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQK6"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="20086" checksum="D2D62E8FF4D3189D" modified="2020-06-17" version="1">MVVPNALKPLSSVIDFPTGKEARTGSRATVRIYHESFRDFLMASNSKDKSQFSIDKGETHGILLTRCLDLLKNKLGRDVCKLKDAATEREGVSAEDVEKHIPESVQYACRFWTSHAVKSNKTLEVVEAVDHFLREGFLYWTETMAWLDKLGEMIICLKQLQKAIDVCIASVSVCQKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRC8</accession>
    <name>A0A6A7BRC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_158710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRC8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18566" checksum="3DB57F3B73024837" modified="2020-06-17" version="1">MIVVIYHRVSQWIMPHPQPKTAHPKLRVGDHQLIFERRASYWFVLYVQSSMMMSCQFNPVRWHRCHTAAQIFALLSFPPKGSLPSPAVPPPRICGGMFLSSWDKPVGGELVKISSSRVGGDSDQVEDVQGRNLSVGWFGELGIFEAESITRLLSRRMMEFHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRE2</accession>
    <name>A0A6A7BRE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sister chromatid cohesion acetyltransferase Eco1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_279035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRE2"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="10">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="11">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2857813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48519" checksum="E9A84AB313216E6B" modified="2020-06-17" version="1">MAGVLTGAGIDHVFNEVKVKLVVNLEAEKIVSVSEALRVIVSVGIESSNSSSEHDSELHYEGVNDGFVSVNEGKGDFIVNCAAVAGTVKNWSAPSALGEKQSIVMLDNVYTILHMDSSDLSSSPVGKIQLFSDIAQRSLSPPSSPPAYPGERQSNNKYIAPSAFAVLGKRKSATPVTHAARPTKKRSACDRLTQLQINLGQTIQKQCPTCGMEYVASSAEDRKLHDRYHQQAVDGYDVGKEFAGKARLGTVFPGVLEGDWICAITHLDHHTRRKKVQSVLESVQRELGAVPISAQQLWASSKDRGPHFTAYLYVRGTKCVGFALTVGLSEARLVLKPQVNPTKPILHHSVSAVEALKLRRLAAAEAEAQATSQPLLVSSVPVPARLGIARIWTSPRCRCEGIASSLLDTALASTKPLTKDDVAFSQPTEAGTRLARKWFGQLYGWKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRL2</accession>
    <name>A0A6A7BRL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_169779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006038">
        <property type="protein sequence ID" value="KAF2857537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRL2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="19722" checksum="250138D1268740AC" modified="2020-06-17" version="1">MRDGTEMTTAKKRAGACASGEQLQSRVNCAASFRRPLRSAPLEWYSTLRRFPLTAVQRFVETAEGCAGCAGSTEAVYQGPRDDNRRVGLTARLGHVAEIIMPRRARCLDVYADVSSNDTTRMATSSRSQQRISSPAVNYGCTAHWHITAGEQRPHSCPENHCHNQSQRRPLADSPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRZ0</accession>
    <name>A0A6A7BRZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_253125</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRZ0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025711661" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="548"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2857525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="606" mass="68524" checksum="4E38444469745ED3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA7</accession>
    <name>A0A6A7BSA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_237040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA7"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="145"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="55915" checksum="AFA4B91E9BAFE29A" modified="2020-06-17" version="1">MAQDDADPRMMKVQPRIRYNTVGGINGPLVVLENVKFPRFNEIVSLTLPDGSERSGQVLEARGSRAVVQVFEGTTGVDVKKTKVEFTGHSLKLGVSEDMLGRVFDGSGRPIDKGPPVLAEDFLDINGSPINPYSRVYPEEMIATGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVAPTKGVHDGHQDNFSIVFGAMGVNLETSRFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDISSYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVQGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRQLDNKGIYPPINVLPSLSRLMKSAIGEGHTRADHSDVSNQLYAKYAIGRDAAAMKAVVGEEALSNEDKLSLNFLDRFERTYINQGAYEKRTIFESLDMAWELLRIYPKELLNRIPKKILDQYYPRKGRTEDADKGNKDTRDNCDKLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSD9</accession>
    <name>A0A6A7BSD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_251735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSD9"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="295" mass="33746" checksum="3F7735062F802E98" modified="2020-06-17" version="1">MKYVPLPQFDIVSQALNFSTIDKHVVGGCDLLITKPAKQDKKLCKKIYATLDEQHESNLQLARTVSRFRKTYGSAPTGVSLPTEIDVSCKSAFGPLSQKRARKTLAHLIATLNASHTDYDFSLDLRPSDFRRVTSLRRLMYDIDSELYHLRRGPCFPPSLVSDTPPKTAPPVFNERGLAVWSVRMWALIDDQIKLHQSELYRWAPQNNPLTLYEGDMWSKHYLFYNRREKRVCYLHYRVASALSRSAPSGLIVPDGYESDSWCETDEYDEPMNDLPCFGDDCAEESVDFTGNMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT10</accession>
    <name>A0A6A7BT10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT10"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="122"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="613" mass="68611" checksum="94F0483A3955CAE6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT70</accession>
    <name>A0A6A7BT70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_236658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT70"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="23029" checksum="8AA84E3122E681C8" modified="2020-06-17" version="1">MGISRDSRHKRSATGAKRAYYRKKRAFEKGRQPANTRIGPKRIHLVRTRGGNRKFRGLRLDSGNFSWGSEGISRKTRIIGVVYHPSNNELVRTNTLTKSAVVQIDAAPFRQWYETHYGQSIGRRRQQKAGEKVEEEAKKSKSVAVKQADRLKKAGKPELPIEKQFEAGRLYAVVASRPGQSGRCDGYILEGEELAFYARAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTQ9</accession>
    <name>A0A6A7BTQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_259710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTQ9"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="188"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="327"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="627"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="814"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="967"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1080" mass="120721" checksum="2419D691262AA88C" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU0</accession>
    <name>A0A6A7BTU0_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025583249" evidence="1">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="404" mass="41094" checksum="8F0A41073A2FE47B" modified="2020-06-17" version="1">MYAKTVFVLSLALQAYGHIGVATPKIIPGSGGINGLNPLDASGSDFPCHGIALPTTGGLPMAAGSSQLLSFNLGGGARTAVHGGGSCQISITYETDPAKQKDPKNWFVIYSVEGGCPSNSHLNLDGVYNGPQGTYTGALSCSDPRSNGVDCVNDFNFTIPHGVKSGHAIMSWTWFNTVGNREMYQNCINAELTGGDGSEMDKFPTMFVGNLAEINTCPTTIFFDLEFPFPGEYATKKKPSGIAGSTASVYPMAKPTGAGCDGNGAPHGGYVAPAPSSSGAQESASASPDVYSSASPAAYPSASASPVGYSGVASPVQTSAATAAPTSTAAASTLQTLASPSPSVNSSPDGKCALGLVPCTGEHIVCIDDKSFGFCYDGCAVKQPIAPGTACRDGKIQGIFGRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU06</accession>
    <name>A0A6A7BU06_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_252206</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025493718" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9137" checksum="3A2FB2E6EF9EE7D9" modified="2020-06-17" version="1">MASSILPLVILLLIVAIAATVGYQIYLWSVKVSAEGKNKLQKKNVNLHRDGMKIGVKQLSEEEYEGRTQRYVYFGLDGGGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVL3</accession>
    <name>A0A6A7BVL3_9PEZI</name>
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            <fullName evidence="7">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_259070</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mu homology domain, subdomain B"/>
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    </dbReference>
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        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="476" mass="51569" checksum="4386DF1CEC70B244" modified="2020-06-17" version="1">MSTIEAVYIYEHDTPILEHIYTSRPPSAATLLTHYLSHPTPRPSVLNLPTLGTVIFTCVEHNLLFLTPSSRDIDPLLALTFLHRVSDSLIEFLGSPLLGSTITTHTHLVSQILSSLSDSGLPSETEPNALRDVVHTGPGALDNLLGKVGIAPQPAAQQQQQQAQQPAIPWRRANVRHTSNELYVDIVESLRVTLAPSGRPLAAFAEGSIAFTSKVSGVPDLVLSLTAGGGREGLKRLLQRVVFHPCVRLSRWEKEGVLSFVPPDGRFALCGYEVDLLGGCGITEGRLPRDMPLVVEVDTAMGGGDEFEVRLRSSKMRSAAESLSSNLEGRSPAEGVVVRVPLQGDRVRNVVDLRASRGEAVWMPGEEVVEWKVPSGTAAATLRCRVQAAERRSRAVTTTYDYQDGGEEVTDEDRDLADLMPRSATLSFSVKGWLASGVKVDSLVVGSKSRGIGAEVRPYKGVKYLTVSREGVEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVU8</accession>
    <name>A0A6A7BVU8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18a"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01775">
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    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="4"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="21272" checksum="18672346F92EB62B" modified="2020-06-17" version="1">MGRLQEYQVIGRHLPTDANPTPKLYRMRIFAPNDVIAKSRFWYFLAKLKKVKKANGEIVSLNQLTKQIHEKHPQKVKNFGIWLRYDSRSGTHNMYKEYREMTRCDAVESMYQDLAARHRARFRSIHILKVVEVTKTDDIRRPYIRQLLTKDLKFPLPHRAQPKKGRTIFASRRPNTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW13</accession>
    <name>A0A6A7BW13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118949" checksum="16171C4CA96E9623" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2859432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="35902" checksum="11087D8D384F7233" modified="2020-06-17" version="1" fragment="single">CPRPEVDSTDWCTIAGASYLLLCPQCVDHIKRYHPSPTLRHISPMSYGSQCSLGMSPWVRLAWLLTLKRRLPNLDLLEDMAKMDTAPDHSRQWYGIVNREGSFIRGFYVSAASMRKLDQLLPYMTKLFTPWQSRSLPSSVVCALQNDNGLYLDELVNAHTTLDMTRFSALLKKCLRVRPCSRDVVITDGLWHYVPGVSGLTVCEECYETVIEPWAERGSEVARRFNRTLQPLYGTYGNSCQLYSRRMRDIFWRAAESNNGTLLERKGAERREMETRLQARLREAQRRWTGDKLRRELEWISGEWRRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWK2</accession>
    <name>A0A6A7BWK2_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Response regulator</fullName>
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    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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        </location>
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        <location>
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        <source>
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</entry>
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    <name>A0A6A7BWL4_9PEZI</name>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX33"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2859926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="620" mass="68464" checksum="AE9612521CA81A9D" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX39</accession>
    <name>A0A6A7BX39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_282436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
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    <dbReference type="EMBL" id="MU005988">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABL9/DENND6_dom"/>
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    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
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        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="6"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="602" mass="66945" checksum="174F6103956B6FED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX71</accession>
    <name>A0A6A7BX71_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_100461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX71"/>
    <dbReference type="OrthoDB" id="3923199at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24902" checksum="24E03CAE0D932585" modified="2020-06-17" version="1">MLACHFYYSTNTSNPTPNTDGILLFYATNTTTLTSYMYKAGVWVYQTDWPGENAEAGVGCYTHPSTSRAQFMVYKQDQAVEFWSKDMSFDAEWWGLCTYSLKLGENETWVGNDGKDFFAQNEDDMVTVREIEQADKCNGTMAVGEPVLVGKKAREGTRLDGAEVVTTNGEKVRWVFYQESQGNVTGYAAKGSGGWEGGGGCALLLSLEGLLRVGLERCLWFDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXD9</accession>
    <name>A0A6A7BXD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXD9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17200" checksum="726FB29D7603E08D" modified="2020-06-17" version="1">MFKETAILSPPPSPRIILRASLPIRKRELSLEDEMNPSPTNKKRGLPQGEVDSPPSKKRKVLKDLTNCPPPAKRVKSLESSPPSTKRVQVLERDSPKRFKGVSGRSTRNRMAMRDAHSKREHTRFFLKFTRKPTGQFGVVAYSVPFVPRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXE5</accession>
    <name>A0A6A7BXE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_282503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXE5"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2859763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="428" mass="49137" checksum="D2A898F6B4BDE42A" modified="2020-06-17" version="1">MILFLVAAICLIWYLSVVTVSLLGIIQLRRHYTRPPYITLIRPIKGHEPHLQTCLLSTFTQTYPREKLHIRFCLSHPSEPAYHLVTRLAKEYSLLGFDVQVSISSDEETQGPNPKIRNMASAYRNAGRDHIVWILDCNVWVAPPTAERMVDTLLGNVKFVHLLPLVVATMDWESRNADRRRGKYLEEMFTCTSHAKFYTAINTVLIAPCVVGKSSMFRRKHLDLLTDGKGIEFFAWNICEDHLIGDLLWKGRLPPPPEEGGTWRNHEICWGTLAVQPLGSMSVLDYWKRRVRWLRVRKYTVTLATLVEPGTECFLCSVYGAFAVGVYFGWTSAAVFWFLSVATWCVGDFFLYRHLLSCKAVEREGAVPGFIAEGRRVGFGQWLRMWLGRETLALPIWMVAFWGGDTVEWRGSKFRVGRDMRVTELKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXH4</accession>
    <name>A0A6A7BXH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_258232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXH4"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000172">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="224" mass="24603" checksum="270586C2B6E788AB" modified="2020-06-17" version="1">MASNPFGRTHGLNLRGGHHHQPTAQPAVTTQQTQGQAAQRYDRERRGGNLEEPNLLDSLSEEQRDEVNEAFTLFDLDKDGMIDYHETKVALKALGFDLSKSEILQILQTYGQQSAAGGAGRQGGGQHAAATFTGPNRILLSAAAFRQVAARKILDRDPKEEIMRAFDLFDADNKGIIDLEDLRRVARELGEGLQEEELEAMIAEFDIRGDGGIDRDAFLGICLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXL8</accession>
    <name>A0A6A7BXL8_9PEZI</name>
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            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
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        </location>
    </feature>
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        </location>
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            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859961.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="489" mass="53389" checksum="C8EDC5B17C7B323F" modified="2020-06-17" version="1">MPPKKKAEKMALGAFMSNQALGSWADEMESMPIPAPSTREREAPANRSFTQPAWGQARNGTADLGTGGRDASYDRPQFSDREQLPMPTRPPFTAHLGNLTYDVTSVDIEEFFQGCHVTSVRIVEDKIDRKPKGFGYVEFATLDDLKSALDRSESNFMGRNIKISVAEPLAARDRAEGTRDISDWTRKGPLPALPMSSRQSSHRGFSRNLDNTSDAGSDRGGRKGFFDDGKVRDLQNWERKGPLSPVPGTGPPVRDGGRLREGERKEGASWGEGRSESSRPRPAAERVPTAAELDNQWRSKMRPDPSPVATPDASAPASPASREAPKERPRLKLAKRTISTTNGASPAASPAESKASPFGAARPIDTAAREREIEEKRLQALKQKQEADQKVKEQKSESKPTTASWGPSSRSRNQHQNQNGLKPQTPKENDEKQPVATANREEVATTTEGTKNETSEASNEQSVSGANSPQTEEGWSTVASKGKGNRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU6</accession>
    <name>A0A6A7BXU6_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">14-alpha-demethylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="13" type="ORF">K470DRAFT_258374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="476"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="536" mass="60056" checksum="DABF0254644389E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY57</accession>
    <name>A0A6A7BY57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal-dependent amidase/aminoacylase/carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_282188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY57"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="428" mass="46313" checksum="B10BAA87AEA45F50" modified="2020-06-17" version="1">MGARSSGRMVETYRANLDPYQDVYKQIHANPELSHVEHETSDLIAKRLNEICKDFHICEKVGGTGVVAILRNGSGKTVLLRADIDALPIVERTGLPYASKKRMKDSEGIEKPVMHACGHDMHIACLLAATELLVSAKDTWSGTLILAFQPGEEKGTGAQAMVDDGMYSADKHMVPVPDVCFGGHVLANRAGTVGTRSGLIANSADSMRVTVHGRGGHASMPNHLIDPIVMASSIILKLQTIVSREVDPSDSAVVTVASIQAGDADNVVVDDAELAIDVRCTNAETRKKVNQSIKRIIDGECQASNAVKPPTYRVTRTFPLTINDQDTTTRLQETFAAHFGDEFSPNCARMPASEDFSNLATCNKVPYCFFIYGGVDQDLYDKAVKDEAISERISSNHSATFAPVIMPTLQRGSDSYAVAALTYLIKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYF7</accession>
    <name>A0A6A7BYF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_217853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYF7"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="3">
        <location>
            <begin position="134"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="38029" checksum="77DDC10886CDB82B" modified="2020-06-17" version="1">MQIQTQTHSITIHVDNRSSSPNLRFLQSQARWIRDELDPQIAINGPDALHSDEILKLDDLLRTLQDASLTITDLKTTRIHLAVLLICSQGTRWPRRLIDRSDQLTHMWERKFQSPLKDIGILLYEPGGRLHGVCQPNDIDEEALINHWRETNTLGGLFAKQSGSLRFRPGDWWISPLFAYRAGIISTPSRSGGIISDPERAYAILMTDDSELCGPNAEEFFYRAADTDRGKFSLTSATPESRTPVRILRSHTLRSFHAPKAGVRYDGLYRVTGWRVLPDEKTKKTKYEIGFKRLENEPSMSSVLRRPTTDEVEDYTEYKRLRRRRRRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYG4</accession>
    <name>A0A6A7BYG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_271320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYG4"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="523" mass="59069" checksum="DA1F524C4A08B2C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYQ2</accession>
    <name>A0A6A7BYQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="739"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860217.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="18261" checksum="03ED7C15501D98BB" modified="2020-06-17" version="1" fragment="single">RELLCCGRCICLRRLRANPRFETYCAHCQATSNPPSYTSRAEHIEDELPAYPSSSRLQLVKKKDEPAPDVLHFLSPDDTIASLALSYNVPVDVLRKKNSIFSGHLIQARVTVLIPGSHYTASVSLSPSPVEGEEADARKRKIRRWMIACKVIDYDVAVFYLE</sequence>
</entry>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17943" checksum="CD3918BB8AC96F0E" modified="2020-06-17" version="1" fragment="single">MYSHTISLWTVHLAVLFGTFLAATAPITPMNLKETPPTKTIPLGPNTRPLPMPWEKWPFSEENPFYLEERLQIVKPYSPKGNKLCTLDNCCLLGKKEKLTPKCFWNRKHGFRKTYGKHKGNMGIKYGFYEGIAKDFLVWEKWKPGKSEFFSDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZI7_9PEZI</name>
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            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_79489</name>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="1093" mass="123694" checksum="F0FF6C5B102AEE75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZI9</accession>
    <name>A0A6A7BZI9_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="806" mass="87892" checksum="3B45A149778B133E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZL1</accession>
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            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZL1"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="140"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="391" mass="43338" checksum="1F172BFBF61AFCFF" modified="2020-06-17" version="1">MKQRIRERIAQASFSSEHAGALAQANLPPGAGKAAQDIVGATPWSGEESVADGALRMLTDKYKPKPSGVRMPTRVDTGRPSKSDSGSRLANARDSSSAYATLKDGSMSDEERHRFRQEMKARFQSDARSIPASIQALGSLANERIEDAIARGQFRNISIRGQQLQRDHNASSPFIDTTEYLMNRMIQKQDIVPPWIEKQQELAQAVDRFRSRLRADWRRHVARSISSDGGGVAAQVRRAEAHAVAERQMQSKAGVASSGALEDPEGAKGEDWGTVGPFRDRQWEATEARYLCAAVANLNALTRSYNLMAPDLARKPYFHVERELRSCFADVAPTVAEAIRQRARAPPTRDSGAGRAGNGVLERFTLDGAGHVHDERRPQYGFREFWRDLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP2</accession>
    <name>A0A6A7BZP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_65200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZP2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="18969" checksum="4813000EE7FC12FD" modified="2020-06-17" version="1">MPVTVQHFCAGTRRIQGGICVANACAAALWHMASSRFPGGYVASLKNIRPYQALTCSREKKGNRLAHDVQRKPNGWWLVVRSVYPLDCCRIAVGGKLPNGSRDPLPPPTPPLPRSLAKSAYQALSLDAAMRTAKSLSPPVWIGSRVWKSLGSTTSSHRSACTLLGIYTAGIWKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP3</accession>
    <name>A0A6A7BZP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_258310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZP3"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="359" mass="39683" checksum="5521F8DB5BD1AA69" modified="2020-06-17" version="1">MAPNLKVKAGVIYGDDVLSLFKYAHENQFAIPAINVTSSSTVVAALEAAQKANAPLILQVSQGGAAYFCGKGIDNKNQEASIAGAVAAAHYIRAVAPSYGIPVVLHTDHCAKKLLPWLDGMLDADEKWFKEKGEPLFSSHMIDLSEEEVKYNIETTAKYLKRAAPMKQWLEMEIGITGGEEDGVNNESVDNNSLYTQPEDIYEIYKTLSPISPYFSIAAGFGNVHGVYKPGNVRLHPELLSKHQAYVKDKAGLKEDKPVFLVFHGGSGSTKKEYQDAISYGVVKVNLDTDLQYAYTEGIRDYMLNKREYVNSQVGNPEGADKPNKKYYDPRVWVREGEKTMTKRVEEALKDFNAAGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZW5</accession>
    <name>A0A6A7BZW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_216320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZW5"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="513" mass="56975" checksum="1DEF7A52E5DB6058" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZW7</accession>
    <name>A0A6A7BZW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_192733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZW7"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11779" checksum="80E8E3B513955E74" modified="2020-06-17" version="1" fragment="single">MFYSMYLQSVCQRRQWPDPLYEPYRYRSHYYCKVRVNNREYCTDVPYKTEALAKEGAAMNAYMICRNFSHNDGMFPGQRPGHRSATGVVQGLPVAIGTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0F3</accession>
    <name>A0A6A7C0F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_270222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0F3"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="30077" checksum="A19E46C9EF7FD124" modified="2020-06-17" version="1">MSLDKSIFNADLYTSLHRFWFGDSSNRDYSQNASKWFGMGQTPAQKKAFDNECASHFSRALESISPSKYPLREWQGYDQDLQHAHEIAAPFLAQLKSPPKTENSNEETLLSMCILLDQIPRNIYRDKQTLPLVYNHYDRISFALVNASVDVIRTTLKKVGGGGRHPMEVMWLWMPLLHSEYRPAHELVGEFVRDVKNRCAPDSQEVKMMEMAEKSAVDHREIVKRFGRYPHRNISLGRETTKEEKEYLVTADTFGVSQDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0R3</accession>
    <name>A0A6A7C0R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0R3"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
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        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="98" mass="11041" checksum="2937C85E27C30089" modified="2020-06-17" version="1">MREWVDLLVKIVTSYVDATRRKFVKDPTGESTTVPYLGRGSRMMYRFIRGTLGIRLHKGLEEHSTRNPRGRTIGGDISRVYTALRGGEMRGVLVGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C150</accession>
    <name>A0A6A7C150_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_270078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C150"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="19954" checksum="93344C71821AC077" modified="2020-06-17" version="1">MDSQDAEIARQMMLFAPVFDVESNVILEVLCLPWAGISSILMSILEEIEVVLGSNHLLTAYSAIYSQVDATSALAHLYNHLVTLYGLIREFLAHAHRTYDMHKWEETAQCLADVVIPNFEANHDRVLEIIEHHARTVDREVSEKQQAWVTEKLKTLKKHRQRSIKELEMFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C184</accession>
    <name>A0A6A7C184_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_257140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
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        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <position position="298"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="417" mass="45034" checksum="8BB3C6A4211C87A1" modified="2020-06-17" version="1">MTPKARNYYSSASDDMFSKSLNSTIYRQILLRPRILVDCTRVSTRTTFLGHEVSLPFFAAPAAMARLGHRDGEAGIAAACAKFGVMQIVSNNSSMGIEEVVGRTTLPPQPPQPTPPTPPLFGWQLYIQKERPKSEEMLRRVGKLPQVGFICLTVDAPVPGKREDDQRTAFTAGEESSSPSPSSGGEEGKATPSPQNGDAKGIEGGAIHPPSQTDGNPNPQSAEKRKEIHLEESPPIAGGVGKALSAGMDTSLTWSTALPWLAKLTHLPIVIKGIQTHEDAYIAYQHYPLVRGIILSNHGGRALDTAPPPIHTLLEIRKFCPEVLEKLEVCVDGGIKRGTDVVKALALGAKLVGLGRAPLYGNAAGGEKGVERVWEILKDEVETAMRLLGVERVDQLGKRHVNTRAVERDLFDGRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C186</accession>
    <name>A0A6A7C186_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C186"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="20881" checksum="77AA0D75F066619F" modified="2020-06-17" version="1">MHETSYALATNYHAMGTGNDNNSDERARTSAANDEPAATSFLKQGYCESIVLPIKDSQVDKECRAGLAQAYANDYGLNLGAGTLHTGRSIKWFKQFSFADPSTQQRVTLDRLEFVLFHDNSIGNVDCIFSNKTADGNRRISLRMFLTSSHPSVLNKVLTGLPLRRFTDERAITTGAPAVKSQRLYLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1G2</accession>
    <name>A0A6A7C1G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpX, ATPase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1G2"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="384"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="497" mass="53949" checksum="C65F6D066C1E78AA" modified="2020-06-17" version="1">MPRFPRPKSKLRYSTFTGGYTGEYTAYSAPQGPLYNASKPLPTPRQLKEHLDRYVVGQERAKKVLCTAVYQHQRRIQELQRREDEADEYSRIGEWDPRQTSPSHPQRSGEEHSQSSREWALHSYLHSSLGNTSPEPTLQKSNILLLGPSGTGKTLLASTLSTLLSIPLSISDCNTFTQAGYVGDDVEVCVSRLLSSANYNTALAERGIICLDEIDKLARRGGSSGGPPGGSPGRDVSGEGVQQALLKLIEGTDVEVTVRSRPGGTGGAGAAHSAFNQGRGETYKLNTENILFICAGAFTGLERIISSRTGKQKIGFSNPTESNDSPKDHPKDPPKNSQRNDSSKSPTPFPSKASSLPTPQDLIEYGLIPELISRLPLLTPLEKLGVSDLIRILTEPHNSLIGQYIHLFALDGVELRITREAMYNIAVQAEKLGTGARGLRGILEGLLSDAMFSVPGSGIGYVLVREGGRVEVFPHGDGGRFRALYAVEEERWAGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1S6</accession>
    <name>A0A6A7C1S6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_216644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1S6"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="21195" checksum="C60F1EF1B6D301A4" modified="2020-06-17" version="1">MDRVPDVFNDGLHLPKMMVFDLDYTLWPLWVDTHLSGRLKGSQDGRSVTDGSGTSYAFYTDVPGILSALKEKGILVCAASRTHTPDRAREMLRLLRVDEETKAIDVFDYLEIYPGSKITHFRRLHKTSGIDYKDMVFFDDESRNRNVEELGVVMQLVRDGVSRQEVDAGVATWRRQTKQREPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2A8</accession>
    <name>A0A6A7C2A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_214829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2A8"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Z3"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="285"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1155" mass="126341" checksum="103B38ABE0B6A899" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C397</accession>
    <name>A0A6A7C397_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="56" mass="6475" checksum="EAA7662E6F1979C2" modified="2020-06-17" version="1">MEDEEYHRTLMQNLIAALLMIINLTPSTATTTASSPPRFFIWRGIAIVFRERCDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3G2</accession>
    <name>A0A6A7C3G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBP11-like subunits of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_263275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="118" mass="12505" checksum="5F748A891C339649" modified="2020-06-17" version="1">MEDVAAAADATTAAAAALPKKQNLRLLPGSTETAASWEFAKESHTLGNALNYVVSKNPDVQFSAYTIPHPSENVMNLRIQTYGQADGVSAASVLRKGLADLQELCDVVEDKFKAAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3R9</accession>
    <name>A0A6A7C3R9_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_214556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF14">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="101"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="521" mass="58827" checksum="05B1EC592B3FA868" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3U8</accession>
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        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256127</name>
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    <organism evidence="16 17">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
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    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="14194" checksum="3B774E498603E478" modified="2020-06-17" version="1">MTGGKSGGKASGAKTNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTNKSGKGPSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Z5</accession>
    <name>A0A6A7C3Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SIN1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_35896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Z5"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Ramirez L."/>
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                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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            <dbReference type="EMBL" id="KAF2862396.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="11"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="140" mass="15326" checksum="CA838A9B27EDB516" modified="2020-06-17" version="1" fragment="single">RRWQSTADNPKISTIVDQISQLTLLETADLVSLLKTRLNIPDQQMFMPSAAPAAPAAEEPEEAAPAKEEKTLFTLKLESFDAAAKPKVIKEIKSLLGLSLVDSKKFVESAPKMMKEGVTKEEAEKIVETMKALGGVVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4R9</accession>
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        </recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="EMBL" id="KAF2862387.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="23155" checksum="D4596EE33953279F" modified="2020-06-17" version="1">MEKVSNRISHRDRHLHSPFGQSLMHTFVFDLRSALVLGGSPLRQTPCPIAQCTGFEYALRAQCNVPPSTILNVNRFFQCCKVHFQRSEARVACNGLAMPAGSKDVLTRTAWDLTEPQSLETFKARVRALAETFPNCQAWLAWHVSRGEYILQALSSCSETSWLFNNTNAQGSLGWGIQRNASKKRTTIVDTMHHAIRCHVRSFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="6"/>
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            <dbReference type="Proteomes" id="UP000799421"/>
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    <sequence length="136" mass="14344" checksum="607F1A51B5DBAEB6" modified="2020-06-17" version="1">MNHSAIVLLCIVLAAALMAIVGAFMWLYNRGDSSSSANNHASMSNWWKHGYGGSVDTERGPAQNEYMRHVRERNSMILQGAAGGARGGGGYNGGHAYSGPGSRDSYAAASAGAYGGKGGFYERRDNHSGSTVQYGY</sequence>
</entry>
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    <accession>A0A6A7C5A5</accession>
    <name>A0A6A7C5A5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
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        <name evidence="13" type="ORF">K470DRAFT_273106</name>
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        </lineage>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
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        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
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        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
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            <begin position="5"/>
            <end position="239"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00003982"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
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            <dbReference type="ARBA" id="ARBA00013870"/>
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            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000325"/>
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            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857647.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="457" mass="49785" checksum="323EDA1282FD5827" modified="2020-06-17" version="1">MGKEKTHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEDRYNEIIKETSSFIKKVGYNPKTVPFVPISGFNGDNMIEPSTNCPWYKGWEKETKAKVTGKTLLEAIDAIDPPSRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGTISPGMVVTFAPAGVTTEVKSVEMHHEQLQKGTPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGCDSFNAQVIVLNHPGQIGAGYAPVLDCHTAHIACKFAELLEKIDRRSGKSIEQNPKFVKSGDAAIVKMIPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVVKSEKSGKVTKSAAKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5G0</accession>
    <name>A0A6A7C5G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_242662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="197"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="5">
        <location>
            <begin position="944"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1593" mass="172630" checksum="317DA6A5255EE355" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5G4</accession>
    <name>A0A6A7C5G4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_280792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5G4"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6F4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025467808" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="144" mass="15497" checksum="867145A9646C7B60" modified="2020-06-17" version="1">MFTQLLSVIALAGAAMAAPAPVAASELAESAALVPGLSTSATYYDQTAEGTCGHEIGTVRLRGGYCYALHTQGIKLDALPDHDCVFTIYHNTDHCETIEGKTWTEEWQVNRKTDQNQGTCAYTSLDNGPLTQVNAVSGVWWCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6F6</accession>
    <name>A0A6A7C6F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_156458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6F6"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="202" mass="21893" checksum="914479454BDF84CB" modified="2020-06-17" version="1">MSYSNTNTGNQPADPYTAKNLQEPPLKEKIDDLVKFVDKCKFCMMTTRTANGQLVSRCMALAAKEGNGVDYIFHANSESGKTDDLNAHSEVNLGFLNSSGEWASISGLAVVISDREKIRKYYSPSLKAWIGDLGDGKHDGGPDDPRIVTIEVNSKSIQYAVSSKSIIGGAIDLAKGVATGETPQLHKLRKIDESELNQVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6G9</accession>
    <name>A0A6A7C6G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">K470DRAFT_255734</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
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    </dbReference>
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        <property type="entry name" value="MSC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="8">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="7">
        <location>
            <begin position="291"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56900" checksum="F192A23F5DF543EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C838</accession>
    <name>A0A6A7C838_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_198739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="166"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2863145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="46448" checksum="438C4318B3F8E4A7" modified="2020-06-17" version="1" fragment="single">PDEEDDAIPMNGPKHNSTTTLSPILHSEADETGEMRRSPKRRKSGWFSGRVTWVVYILTLVQLIVFIAQLVRNAVLTKSPIEIHPSFNPMMGPSPYVLINMGARYQPCMHKMPNVQNETVPIQWPCPNATSTTGADVSCSLSELCGLGGVSDPVVGGSYDNSPAPDQWWRFIVPIFLHAGIIHIGFNLILQMTLGRDVEKLIGSFRFAVVYFAAGIFGFVLGGNFAATGIASCGCSGSLFGILAITLLDLLYTWSKRLSPIKDLLFIIIDVAIAFVLGLLPGLDNFSHIGGFLMGLVLGVCILRSPASFTRNNARDAFARDVTKPVRYSGISRPSDTADPDHGVHGFMKSPIRFFENRRAVWWAWWLVRAAALVGCLVGFILLLKNFYEWRLTCHWCKYLSCLDITVGGTNWCDVGNLNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C851</accession>
    <name>A0A6A7C851_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_106398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C851"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000003">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="377" mass="41852" checksum="2D8CEB1009443B0E" modified="2020-06-17" version="1" fragment="single">MAAIGNIMDDDMSVRESLATGSRRRRMGDEDDIDVYDDDDEGRSAGSNNGVKDVADEELPAHACAYCGIHNASAVVKCLICSKWFCSARGNTSSSHIVNHLVRSRHKEVQLHPSSSLGDTTLECYSCGTKNVFLLGFIPAKSDSVVVLLCRQPCASMGQGSSRDMNWDTSKWQPLIEDRAFLGWLVGPPTDQEQLRARHLAPQMIAKLEEMWKVDANATIGDVASGAAGLDDEPAPVLLRYDDAYQYQNVFGPLVKMEADYDRRLKESQSQDGLVVRWDLGLNNKHLASFVLPKLELGDVKLAVGDEMRLRYTGELRPHWDAVGYVVKIPNNVSDEVTLELRARGDKGNVPTDCTHNFTADYVWKATSFDRMQHAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C959</accession>
    <name>A0A6A7C959_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_268029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C959"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="109"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="19573" checksum="BC7BC02E31DB611D" modified="2020-06-17" version="1">MSGPKKRPMNTYVKGDRKIEYKIKLTSNVETYSSDASSGEGESQGQQRMAIMLEYPSGYQLVIWHPGKYLRKYEGFDIVEEYMREWRGQTPKGRLETAEEVERLSSELNFAERILGCNVRTSKHYYVKWFGRPWTKRTWESEDFLKVNGLGSITEFEEFYAQLCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C991</accession>
    <name>A0A6A7C991_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_289939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C991"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="28143" checksum="7BAB5E1A62E2D474" modified="2020-06-17" version="1">MHIQSFPMWEGSGNNYAYLVMCPKTYDGVIIDPANPPEVIPKLEKAIDGGFRLQAIINTHHHHDHAGGNAEMLKKYTVPIIGGKDCAHVTKTPKHEEEFSVGNIKVKALHTPCHTQDSICYFMEDDEERVVFTGDTLFIGGCGRFFEGTPAEMDTALNKILGSLPDDTYVYPGHEYTKGNVKFGIKVIQNDAIKDLESFSAKNKETQGEFTIEQEKQHNVFMMLEDAAVKKFTGKSERVDVMGALREAKNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9A3</accession>
    <name>A0A6A7C9A3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_267846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9A3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="25165" checksum="34156ECD81FA02C6" modified="2020-06-17" version="1">MLTRKDTPTVQPSAIRAAGTSKANAIHGHEVPSVHVIGHFHKTRAAAQANAEVLGGLTDKSFWSGRGSQGKLPETHKPTRKKTTTAQPMTPGVTLPKNAGRSPGQCPSTRRGLLIGHASYPICIPKIQLVFGTTFLALNAPLRFAFQGIIPHGGGHAVNAASNPVNHAVSGISHALRSVVTFLLHSSANPLSLPSMPRSAAPLPSSGWGTPAELEHFIDNAAMEEGEITSIYIDSEYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9G9</accession>
    <name>A0A6A7C9G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9G9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="10978" checksum="11FFE45925E2F0F1" modified="2020-06-17" version="1">MPSYQPVRKMIRALSNFSAEALVSIFQQLETDLGSLCHVTLVCKPFDDVRTEVLWRKATNALFQVDSQQSLAKKFRHPHEYDGKGKINYSHLRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9R1</accession>
    <name>A0A6A7C9R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_287214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9R1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="170" mass="19243" checksum="EC780D8E2FF69489" modified="2020-06-17" version="1">MAGAANKERVGLRVCYLLWVPRRVSLVLTSFMFQLTLDVYRSIEYTKRRIDHVVANLPRTDKNRIPALREPTQHFGSDDQLAKYKLLGQIPPASQQDLSSEKKHPIFTSDASIKNNFIESMIHQDLKSSSDPNTAASKAELAAHHLQELQPNAASPKVFPRCTRTISCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9X9</accession>
    <name>A0A6A7C9X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_208916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9X9"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="388" mass="43032" checksum="C39B89E22144F36E" modified="2020-06-17" version="1">MEILATTIHQTLDTPIPNDPIHLCGIAVQSDPDEALSLAQKEIIIPPHPIQWRRLFEDASLRKILHLCTQNSPPNKHLINTIISILDTALLTSGAPFRRDLIFTLITELEPFLPPQKTILPATFPSLAPPTGSLNFDIPIPHLNPPTLETFQARALTPLIIPGGVAHWPAISKWTSTNYWMNATLGGRRLVPVEIGRSYTDPDWIVKTMPFRDFLERLIKGERVYLAQHDLVNQIEELRGDVLLPDWSSDAPQPEGSDAGSDTSPPPSDNIQTNTWLGPSGTQTPPHRDPSNNVFCQVMGYKYLRLFPPGDEHRLAPLREKDPATGAEMGNTSSLDVDFFAFGRTSEGGVDVRGLEGILGPGDCVFIPKGWWHYVEALTTSGSVSFWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAD6</accession>
    <name>A0A6A7CAD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_2999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAD6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="111" mass="12480" checksum="3404A3C5FF51283D" modified="2020-06-17" version="1">MRFALRRTCHGASIVHLDHALPATLVYAWLLVETSALSRFARKRSVTILWLVWPYIGLFVASIVRGCPAPRSRYILRKSGGYNGSTAGIIRLLLPRYACNAREQISVQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAX3</accession>
    <name>A0A6A7CAX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_203703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAX3"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AURORA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="33430" checksum="28C8A2B473C39AA1" modified="2020-06-17" version="1" fragment="single">MLPTPPPSPINEPASSLGLVLANRFQLTEVLGVGAYGTVYRAHDIRSGARYAVKALPKSDDPRHHKFLQRELALHHAASSHPHVASLLHVVDSPDTIYAVVEYCDGGDLFTQITSHGKYVGDDARARNIFLQILDAVAHCHSRGIYHRDLKPENILVCEEGWIVKLADFGLATQDNVTSDFGCGSTFYMSPECQQTNPPPNSAYASAPNDVWALGVILVNLTCGRNPWKRASPTDSTFREFMRDPNFLSTILPISKELNYILKLIFDLNPSRRIGLAELRSLVARTPHLTRPATPPTPSYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAX8</accession>
    <name>A0A6A7CAX8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254205</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005957">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
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        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="221"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63554" checksum="1FE59E844D8513A5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB33</accession>
    <name>A0A6A7CB33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_2932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB33"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025578654" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="95" mass="10459" checksum="DC7256FDC7594F0F" modified="2020-06-17" version="1">MTIFGTPVWSSFALYVLAWLCEAREQQGSEMQCLFSTSGMNDPTHLDMDAPASKVLICLVALRVAQRLSDRGFVSRKIMPDMCQHGANDLAGALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBP6</accession>
    <name>A0A6A7CBP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_267294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBP6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025691933" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="24681" checksum="B351FEE071D5BB41" modified="2020-06-17" version="1">MRTTSTVWAAALVALSLSRPLTRAEAAPTHQQLDAEQPGYHFPRLFRRQYGNTTSTSSEITPSTTTSVLPTSLADTSAYSAPVSSTEYPSSAPSLSDYSTISASSAASSSPSSYSSSQLSTLSVAPSSSDAPTSYGSSSSSYLPSTSSGVASSTMDSSSSLSASSSPSSVSSYVPGTSSQASGSSSDSVLTSSDFSSTSSYTPETSSNAGSSSVESSSGSSLAPHSPSTSSISIICLVLLIEHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CC69</accession>
    <name>A0A6A7CC69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="3" type="ORF">K470DRAFT_254418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CC69"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="25067" checksum="08D592A6D1DFE5F2" modified="2020-06-17" version="1">MDSFTVSEDLVTSPSHKQAGTSHTDFDGLLAAKRQLKLHEDLAQGNGGQAWPAGHVLAKYLLRTCRETLRDCSIVELGAGGGLVGLSVALGCKLRQPIYITDQAPMLPLMQKNIELNGLQDHVKAIIYNWGDSRPDNIPSHPDVVLAADCVYFEPAFPLLCKTLEDLIGPETTCYFCFKKRRRADMQFVKAVRKAFEVEPVLDDPDQKTYARENITLCTIKRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNT6</accession>
    <name>A0A6A7BNT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_267093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006071">
        <property type="protein sequence ID" value="KAF2857076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BNT6"/>
    <dbReference type="OrthoDB" id="10298383at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="17470" checksum="7DB08FBC061B6814" modified="2020-06-17" version="1">MRDLEQTDVQRTERLDRYRKLIVEAWRRQRIPNKEMASRIGRSLSLTNKLKAGTTPLTGPIIDQFVEALGIDPVRAMFAVDIAYSHMSYFDPKFHSACTTAITFFDQIMVQCGYGKGIADLAAAEDLTAERVEATARAAAASLATAFVQSHFPGQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPG8</accession>
    <name>A0A6A7BPG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tricorn protease domain 2-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_266982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006055">
        <property type="protein sequence ID" value="KAF2857256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPG8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="647" mass="71956" checksum="4A37D419F262EBC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPK3</accession>
    <name>A0A6A7BPK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPK3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="22068" checksum="A91DF79875ABF41F" modified="2020-06-17" version="1">MDAPFFRGRLPAIECFLGETYSSYSIGSIEHYNEVEFFLKGLRVIKNYFQAHWENLRDRFARIPEGFSHEDVDLFSGLWCAFEFSEDSDNNVQAFNDVEDLLMRGERALGQDTPVGAETLLNSAAEKLRKQLEFLNNSDASVRVYEAAYAKAQRQQMVQLQDMMADMNLARNQINWAQELEETMAQLNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQA3</accession>
    <name>A0A6A7BQA3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005669">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTP"/>
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    <dbReference type="InterPro" id="IPR009072">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="26891" checksum="D0FE4ECA64AF5115" modified="2020-06-17" version="1">MDLPPQMQAQLQRSLAILLTGIGYSSAGPGALESLMGLVDSLMLAFLRDVRISMLSCRRAQPNAVDFTVALSRLPLTRHSSNLSPQLDVRFSDFALHPNYQMWAADGQEFVSAQAEADEAAKTALLQNLMVDKFDYIPSGFPPLPPKHAWMATPVFPPREHDRVKMREHAAVEGDLAEQALKKLTAVSRRGERMGKEQLRGFGGSFEEALMAVDKASDADTREDVRADCERFHWRHSATVGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQU6"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="170" mass="19607" checksum="121D8CDB937E5033" modified="2020-06-17" version="1">MITDRIAVKTGSVGVENWTWMFKPDKKFIPTEIMAPYLMRNLVGSENITAIRNYRIHYKELVYFYRLRLYMEYCPLDDVDGMIMDDRADPTGWGFHKLRRIVGNNAKSVLGMIPEPLLWHLVESMARVGQIMTYGTLDETDPAWRFFSSSGNKSFIAISNRTTLSSALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQV7</accession>
    <name>A0A6A7BQV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_260590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006033">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025646385" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11290" checksum="87AA1B6E355B9413" modified="2020-06-17" version="1">MHFALLYIVAAASMAVAARIDEPTTIVDITSMNSEGIFKYARETTLLRISGLPNNCNFNFCPPLFAKCWTHGCESLRQPECFEAISYPGCEGCKVCQIGCKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR08</accession>
    <name>A0A6A7BR08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR08"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="22101" checksum="A944D4BD93AA1E75" modified="2020-06-17" version="1">MPLRLKLITTDASSTFIVGTEERENIPPESLIVSSKPERPKTNYYRRLPLDDPRSIYWRKELATRFVREQHLSNSNNPSSGCPTSSVPSSNRRASTNSVSNPSTATHPPSTGLASTHQSVTLPKFILTDFPPGYTLWEYVTVANGKHRVRKDFYLYGHPHGVSRRYKSPNHFLPHLCWLSKGMVGKCGCLPCNGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR14</accession>
    <name>A0A6A7BR14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006033">
        <property type="protein sequence ID" value="KAF2857650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR14"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025684972" description="Integral membrane protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43774" checksum="46DF5D5F59006C40" modified="2020-06-17" version="1">MFIGESGCWLVVFLSWLFRKYFHSSDGHRDTDASYAPVATSEVDEGSNVPTNNPRQSDNDFAPAISQTPVDPTNVVAKPFEDGDTMSAPRIPLTGWRVFLLALPAVCDICGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVIFLKRRLGVWKWAALVVVVSGVVLVGLAGVLEKKQEGHVYRPYHPYQDGASADLIRKTVNLARESASALASHTAGETILGVTLIAAAQIFTASQFVLEEGIMEQYTMDPIQVVGWEGIFGFLVTLTGMGVLYPLIGRTPAGKGGYFDIPEGFHQVFHNRAVAITSLLIMISIGGFNFFGLSVTRVISATSRSTIDTCRTLFIWMVSLGLGWEKFKWLQVAGFILVVYGTSMFNDIISPPTAAFWRTQKRTVFDGGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRC5</accession>
    <name>A0A6A7BRC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_273290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="MU006043">
        <property type="protein sequence ID" value="KAF2857437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRC5"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2857437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="450" mass="48803" checksum="B942F41EB03F2D49" modified="2020-06-17" version="1">MEDLHFESFQLHAGAEPDPTTKSRAVPIYATTSYVFDDSAHGARLFGLKEVGNIYSRMMNPTVDVFEKRIAALEGGVAALAASSGQSAQFMALAGLCHAGDNIVSTSNLYGGTYNQLKVFMPRLGIKCKFVEGDSAKAFASAIDENTKCVYVETIGNPRYNVPDFESIVKVAHEAGVPVVVDNTFGAGGYFCQPIKHGADIVVHSATKWIGGHGTTIAGVIIDSGNFDWGSESARKRFPQMTSPSDGYHGLKFWDTFGKLTYIVRLRVEILRDLGAALNPFGAQQLLLGVETLSLRCERHASNALALAQWLEKNEHVKWVSYPGLPNHPSHDLAKKYLHRGFGGVLSFGVKGSANAGRNVVDKFKMISNLANVGDAKTLAIHPWTTTHEQLTDEEKINSGVTEDLIRISVGIEHIDDIKRDFEQAFESAGVGGQNGDDKINGMGEISDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX4</accession>
    <name>A0A6A7BRX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_260790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRX4"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="208"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="384" mass="40925" checksum="A18B19954C72126A" modified="2020-06-17" version="1">MSTAGKPITCKAAVAWEAGKELSIEEVEVAPPKAHEVRIQIYYTGVCHTDAYTLSGKDPEGAFPIILGHEGSGIVESVGEGVTNVKVGDTVVALYTPECKECKFCKSGKTNLCGKIRETQGKGVMPDGTTRFKCKGKDILHFMGTSTFSQYTVVADISVVAVTDKAPMEKTCLLGCGITTGYGAATITAGRGGIEKGANVAVFGVGCVGLSIIQGVVKNGAGKIIAVDTNSGKKPWAEKFGATDFINPTKDLKKDETIQQRLISMTDGGCDYTFDCTGNVQVMRSALESCHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGVKGRSQLPKLVDDYLNGKLKVDEFVTHRETLEGINKAFEDMHKGDCIRCVVDMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA1</accession>
    <name>A0A6A7BSA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_222040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA1"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="275" mass="29498" checksum="C7AECED325183545" modified="2020-06-17" version="1">MASSFRTTQLGEPTLQYPPSAETNCKTVSCAKAADDQLASPSKGFKARYGFLMRDAIIGLADGLTVPFALTAGLSSLGSTRLVVVGGLAELFAGAISMGLGAYLAAVQERQVYRVDEAKEREEIRLRPLSEEGKLYRMFQSYGISEEDAQGVLHALMDDSNAWVKFMMDFGLKSEEPDPKKAWIEGLVMGTAYFFGGLLPMIPYFAIKENVTHALYVSIGITAVILVAFGYAKATFAGCTTRDQTWSALHTLLVGTVAAGVSYGIVRGVNSAMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSB2</accession>
    <name>A0A6A7BSB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_260204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSB2"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="222"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="385" mass="42753" checksum="3D4DB66569537696" modified="2020-06-17" version="1">MAQEKFHKLSAVESLLCPEDPHHPPHDGPHHPPPHDGPPHHPPHDGPPHHPPHDGPPHDGPPHDGPPHHGPPHHGPPHHLYQLIEKSKYTTKLAKLINKHDDIVEMLNSTKANYTVFAPTDKALKHIPCDGDHEPSKEQLKDLLLYHTLDGLYTAKRIFFTHTAPTLLQSTHLSSKKEAQRVSFQLTLRGLSVNFKTRITHPNIMAVNGVIHAIDRPLLPPKAKASLLSLLPSRFSTLELALHKTGLIETLTSSGPAANAFLFSPAGLPYLKSLLQYHIVEGHTLYSDAYYFAEGHGHAHIDLPTLLEGRTVSVDIARWARFVEMKINGFAKVDVQDLVAEDGVVQVTESVLVPPKRPGFEPPVEEGEVEPEELRVRLEGWRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSC2</accession>
    <name>A0A6A7BSC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_252605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSC2"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="20260" checksum="0BD8E6DD4922717D" modified="2020-06-17" version="1">MKAPLSICRPYSTCPKVRATDEDLCAARHWFSAFNKDTIPRRIGNLSFARSSGPGGQNVNKVSSKATLRIPLYTLFAHVPPLLHPLIKSSRYYAQRSNEIIVQADESRKQSENIEICFEKLHNMLLQSGREAIPRKTSPEKAKRVEVLQKIEVSRRKKSKQHHSMKKASRKTCRFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSL8</accession>
    <name>A0A6A7BSL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_259906</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSL8"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="228"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="572"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="924"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="973"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118933" checksum="572CC45596D86D0A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSN4</accession>
    <name>A0A6A7BSN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSN4"/>
    <dbReference type="OrthoDB" id="3635680at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28631" checksum="93AB149705A287F0" modified="2020-06-17" version="1">MYPASWSIDPALQPAPTARVTKRPLTMEANNPPAKRYRAIQPAPLKQFARPPPDVTGLMRLPAELRVEIFTWYLSSISVTINCGPQSNNISTRYRCRCGNRCPICRNYNAGALSLLLVSKQIRNEALPIMLRHSPITAIIRDLDFTPLLEWMSRMPFGDEPKLAKNKNLFIEMSHSMSEGLPKEGQSLRRWLHLRADKCRPQPNWQYVGGLNSKALSGLKRRAKRMNEVGKREELEKLIGAVSAERWEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSW2</accession>
    <name>A0A6A7BSW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geranylgeranyl diphosphate synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_272458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSW2"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="299" mass="33376" checksum="77033539243E8B10" modified="2020-06-17" version="1">MEQEEAWITHADGDAPGSSWSKEKENILKGPYDHLESHPGKDIRSKMISAFNVWLQVPAPSLAIITRVIGMLHTASLLIDDVQDSAVLRRGVPVAHHIFGAAQTINSANYVYFCALQELLRLRNPAAVEIYTEELLNLHRGQGMDLFWRDTLTCPSEDDYLEMVSNKTGGLFRLAVKLMCVESGSQAKAAYVPLVNTIGLLFQILDDYNNLCHPTYLANKGLCEDLTEGKFSFPVIHAIRSAPSNLTLVNILKQKTTQDEVKRFAVQYMEAQGSFAYARKVLRSLNRKAQAQVGAERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSW9</accession>
    <name>A0A6A7BSW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_260193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="38464" checksum="08A563169C3D4F9A" modified="2020-06-17" version="1">MSDASSSRLQKIVCSVYNDVVQNTVHDILLQEHRAHKLLIDSIDPATQLPLCDKCSLPRVLDPPLAPKVCAAAVGSGLLASKETTVFCAKRPWCRTPGHDIFGNPFPRADVTGRNPTKKEREQQAKAAANIKKDGASDDGHNNSHSQGNTGPPSPNAHAASFNEGGTGPRKVEKGDKKPSKIEKLRKGEYVPYYTCPSCKRSLLIVRFAKHLDQCMGVSGAGRAASRFALARISASGSTPTGSRAGTPSLESRDGDPDNGPDQDGSAAVRKRVLKKGLTSKYKRSTKIKLTPAPQPKRAVEGSVVGSEGKREREVDDDDDEADTNDGSPKKRQRLNLERVGSMASFDTASVVEDNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSY9</accession>
    <name>A0A6A7BSY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_222144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSY9"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="137" mass="15198" checksum="C434606802260A90" modified="2020-06-17" version="1">MSHEGGLYDPPTTQGGNDRISQLQREIDEAKRNVQQNIQRTAQRGENIDRLQNKTDALADSAGNFHRGASKVRKQMWWKDMKMRLCILIGIIVLLIVIIVPSGKLVVAAETGSGANDKQSSSTNTTGRKRRTDQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT05</accession>
    <name>A0A6A7BT05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_251449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT05"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="201" mass="22717" checksum="3F08B29C50AF1BD5" modified="2020-06-17" version="1">MKINTTTAIQGRILLVPYCKQHVAQYHEWMQDAHLQATTASEPLSLEAEYSMQRSWREDGDKLTFIICLLDVKMIGDVNMFLFAGEKESPVAEVEVMIAEKEYRGRGYAKAAVSLFLSYVMANWDGIVGEFSGRVGSRGPEYFRVKVGEGNTASIRLFEGLGFKRISDKADYFGEVELRLGDASCVILPKEDWRILHYNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT55</accession>
    <name>A0A6A7BT55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_251367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT55"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="18511" checksum="AD08A3D527A59324" modified="2020-06-17" version="1">MSSELGLDLASKRLRKRSDYQFHLDYRTRWQDNDMYSHLNNPIYGVLIDSIVNEYLFTHCDYKTSSSYPRLALVANSYCDYFGELSYPGVLNIGLRVVKLGKNSVTYECGFFAEGEEKVKAVGGFVQIWVRKTDKRPPDEGLDPVVRRGLERLMGEGKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTG3</accession>
    <name>A0A6A7BTG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_296267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTG3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="93144" checksum="8990021BB9C5B2A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK1</accession>
    <name>A0A6A7BTK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006026">
        <property type="protein sequence ID" value="KAF2857828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTK1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="168" mass="18493" checksum="13F1004A32960808" modified="2020-06-17" version="1">MNQIGEVRTPEASQGFLPRRGVFPCDEITSSRGLGKCGLDPQDTARPSRTTPPSGIHLRSEVHSPHTPLEERAAAGFWPNTQPSDEEDSDSGDDHPGFASMGTKMELDSKDYDYTVDSSTGQTFSGRAKDLSAFLTHVQLKELLYSDLKNHRIKCAYAANQLRDPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTV8</accession>
    <name>A0A6A7BTV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_235702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTV8"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="13176" checksum="C96BE5A09D68D677" modified="2020-06-17" version="1">MDIDYTRRNKKPRLLMPSERAELDEFIDAIHYSSRYNDDTFEYRHVQLPKQMLKKIPRDYFDGARGTLKLLWEDEWRGMGITQSLGWEHYEVHEPEPHILLFKRPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUU2</accession>
    <name>A0A6A7BUU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_282906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUU2"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025416297" evidence="3">
        <location>
            <begin position="19"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="139"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="332"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="566"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="689" mass="74599" checksum="55F49A94AD09400F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUV1</accession>
    <name>A0A6A7BUV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_282912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUV1"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="128"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="47334" checksum="18F8F26E629BF0D5" modified="2020-06-17" version="1">MLDSSTDPISDNGIHLTSLDSKIPDAVLSFSQVLRTYLLTSFSSSPALLSGTTKLLRRMLKSDSFLLSVERNPVLRTLLFETFYRQYCGGSNHDEVSELCSRFKHEGYAGMILEYAREVLSEGIGDEVHDVEAWRQGVLDTIAASNEGGFVGIKWSGMGPDALRRLRDAESPSRRMDEAMHTVCTAAERKGVSLLPSAEETRTLKGFHRWCLAMQRAYNHKGRSVIYNAYQAYLKQTPGILARHLELARQEDFTLGVKVVRGAYLSTEPRDLIWPTIESTHHAYNSIAEALIHRRWNDMVSGNSAWPLINVLLATHNANSVHKAQALRQAQALRGEELTPLAFGQLQGMADEVFCHVLQQNAREESLVKEKVYKLTVWGSLHESLNYLLRRASENMDAAVRTADSRKAMGKEILRRCKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV10</accession>
    <name>A0A6A7BV10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV10"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="249" mass="26599" checksum="B5254B72F3F89941" modified="2020-06-17" version="1">MIGFQALVALSQQFLPELGHFLSTHIGHGHSHSHTDLSGIGPDLNAAWLAAGSILVKEYLYRATMRIAESQRSTVLAGNAYHHRVDCLTSIVALITILASRFATHAEWLDPVGGLLISGMIVQAGWGATRQALLELADVSVDDHVKDDVAEKVRSVLAAGGVGSLRGVQGVKSGQSLLMEVEIGVRRDASLGDLGDLEGKVREEVGTVSGVKRVVIRFVSSDGDEKEPFEDEFVESNGLSNGNEHGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV36</accession>
    <name>A0A6A7BV36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_265578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV36"/>
    <dbReference type="OrthoDB" id="5283561at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54384" checksum="AEF17950E5A3E8B6" modified="2020-06-17" version="1">MHFDELPPEIWSDILRRAALLNAAEGPHFTYGLSQAQLPLEQPSHQPKPVKYVRGPVSAEQLRWDATASIRQVSSRWHHWALAYNLEHIFERRWQGSERWANLSFNRHSYGLYELIDRPSGSYVYRDPFGSLTLTDTFFQRFPTTAKFVRRLWFNGFYAAKTDGLILSIVANCPCLESLTIPWTVLRRASVDQWLDLLKHNSLRGAPLRSLELQAVCLPSDQAAALYKHTSPSALEDDRVSFASLKRLKFFGNTVHKPVTDRDLYLIAQTATNLDCLDITNLSTVSVAGMLALVKASHDTLQVLEHSPRSDDGFFHPFPGHLENGEHICELLTSLPCMRDLSISIPHVCASLFSEEDVQWAGDLQVRAAGLCGIASSGDGEVRAKALATILSKSRQLIKARQRLRKELHVELFFAGCIFKPEDSLVHGDFTTAEALSHGNWPAAKQNSTLGPYGQTGTYGKEENSWIAVSETEFLRGVVNGWVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV73</accession>
    <name>A0A6A7BV73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_282856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV73"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="56419" checksum="C2F4B34B050182F7" modified="2020-06-17" version="1">MNCSVEAFRAFLPFNTVVNWAHNVAANTTFQVPPGDLPYPVSPTGLRSLCAVEITVPSSSSSAYSFGLFLPNEWNDRFLAVGNGGVAGGINWLDMGAGVGYGFASMSTDTGHNSTDTDSCWALNEPEKIVDFGWRAMHGSVDLAKKVVKQYYKRAPKYSYYSGCSTGGRQGLRDAQLFPEDFDGILAGAPAWWTSRLQPWTVQLGLYNLPTNSKTHIPPELFPAVAAEVMRQCDGADGVVDGIISDPQSCQFRPQNLLCHPSERDQVAAKCLFPPQLITLHSIYNNYTDNGSFLFPTLELGSEAQWDVLIGDSEPNPLGYAWVQNFLLNDPNWNFWNYNSTILHLADKLQPGNCTANDFDMSLFASRGKVIMYHGLADGLIPPGSSTYFYEQVQKTMGQVDSWFRFFLVPGMQHCRGTAANAPWYFAGANQAGSINSYMYSVPSFSDAQHDALLALMAWVEQDTAPDRIIATKWVNDNPTLGVEAQRPICPYPKRATFNGRDITCPECWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV77</accession>
    <name>A0A6A7BV77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_271825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV77"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="250" mass="27182" checksum="9BDBC27146DDEFAF" modified="2020-06-17" version="1">MASSNRQFFVGGNFKMNGTISSIKEIISNLNSASLDKNTEVVIAPPALYLLIARENLRSGIEVAAQNVFDKPNGAFTGEISVSQLKDSKISWALVGHSERRSLLNESDDFVAQKTKAALDGGVGVILCCGETLEQREANKTIDVVTRQLDAVAKQVKDWSKIVIAYEPVWAIGTGQVATTQQAQEVHKEVREWLGKSVSKDAAEKTRIIYGGSVNEKNCRDLAKESDIDGFLVGGASLKPEFVQIVNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT9</accession>
    <name>A0A6A7BVT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_277788</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859324.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1707" mass="187906" checksum="D43E68A81EA02CC0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVY3</accession>
    <name>A0A6A7BVY3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72424" checksum="A4B56F6D63FA0F72" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35017" checksum="BFC15BBF6056CE94" modified="2020-06-17" version="1" fragment="single">MDRLLLLLPFVTFLLIGAAYYFFFTAPPILKNSKSAPALTSISRPVVGSIQFFTCRWDFFRQAISLSRSGNFSFRAGQFPIVGVSTPEARKVFFESRQLGFSEGYAALLGGATNLSEDGRTHTLVEDDHAELNSAAKGFGTYFNKRLVNMLKGDRIRKGLPMLLNDAKLGMDALAADPKGITDPFESIYRLVFQFTMRTVACWEIADDPVLMDEVLQLYETIEETATPFSIMYPWLLVPAKARRLYAGAKLYRTFGRVVNERRKTGTRYDDALQYLLDQGDGIKDIIGFVLAALFAGQLNSGINAAWMLLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWT7</accession>
    <name>A0A6A7BWT7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_248962</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="336240at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="169" mass="19449" checksum="26DF2BC260EE3207" modified="2020-06-17" version="1">MSQSLRPYLACVRSTLTAALTLSNFASQASERHNVPEIEAQTSPELILTPLTVARNAEERVLVEPSINSVRVSIRIKQADEIEHILVHKFTRFLAQRAEAFFILRRKAVPGYDISFLITNFHAEEMLRHKLVDFIIQFMEEVDKEISEMKLFLNARARFIAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX21</accession>
    <name>A0A6A7BX21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_259221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX21"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="37569" checksum="4E643471593F2833" modified="2020-06-17" version="1">MAFHTFMKANLDSAVIECGIGGEYDSTNIIEEPLTTGVTSLGIDHEGLLGRTIEEIAWHKAGIFKRRVPAFTVPQSKDAEAVLYSRAKERGTELNVVTEHTALKDIKLGIKGPVQRINASLAIAVAASHLSQMGHRDVPDPLDNISNLPPKFVKGLEKARLGGRCDKRSDAKVPNLTWFLDGGHTRESIELAGRWFAASRSPNALQVLIFNQQTRDARALARQLRDSLDKAMGRAHVFDIAIFCPNVTYENAGYKADLISINVSQDDVDSLRVQREMAEACKEINPETKPIVCGTIEEAVARVRKLAGRDTREVDVLVTGSLHLVGGLIEVVEAEVEREEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXD4</accession>
    <name>A0A6A7BXD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_300171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXD4"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2859647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="21946" checksum="CA96BA5C76FBF653" modified="2020-06-17" version="1">MANPRVEELPDEPKDSSAPKVEDETSSESEGAENANGGEATIPTGATVSIQNRNEKKARKAIAKLGLKQVEGITRVTLRRPKNILFVISHPTVYRSPNSNTWVIFGDAKIEDLSSQAQASAAQQLAAQSATEAAQESANGTGKGKAVEDKKATEDEDDDGGDVDESGLEAKDIELVMAQASVSRAKAVKALRENDNDIVNSIMALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXU1</accession>
    <name>A0A6A7BXU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_248558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXU1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="64"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="409"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="520"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="638" mass="71527" checksum="EE52701FFA78F813" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY20</accession>
    <name>A0A6A7BY20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_282395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5372451at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="705" mass="78597" checksum="D4EFB5A9E2973ABF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYD0</accession>
    <name>A0A6A7BYD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1763-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_258549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYD0"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14429" checksum="5F7F5B4748A18F80" modified="2020-06-17" version="1">MSQDITVLRSAYRRLLRHAYRAVLFSVPGRYQVRDRLRLRFRGPSDEPARNRFRLGPAMSGETPRGTLDMAKVENTIDFLKRATETTGMEHKILKNLVWVWWGQQDVNLLGRKLPLFGRENFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE1</accession>
    <name>A0A6A7BYE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_78419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="53" mass="5940" checksum="EDC733381DAEC4FE" modified="2020-06-17" version="1">MLLSVSQSSGFLPSMIMIAMVQFSRGIYSFPAKQLCHTVRARFGPVLKQTQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYL0</accession>
    <name>A0A6A7BYL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_258060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYL0"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="164"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="307" mass="33882" checksum="EC9AEC7727769B80" modified="2020-06-17" version="1">MTTIFPMVETRVLAQLQLINSQPYGLQSPLRKPTTSKVLRRELSIYRNQQCGSRPIHLRTVRLKSKLSSASICGGVNRLGNPKTLFTMAPSWTHLVRFEAIEDGRIHLGQLKNTNLDVGLALEKGDVVQAYRINGDIFTGTVTSALLTVRRVFSPVTPEQCTYIRCVGLNYHDHAKEAQMSPPKVPILFTKPRTSLTDPYPSTITIPKIAQDGTSDYEAELCVVIGKSGRDIPQEDAYDHILGYTISNDVSARNLQFMTTQWSFSKGFDSSCPVGPTLVSAAAIRDPQGLGIEARHNGVVVQSGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYV7</accession>
    <name>A0A6A7BYV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_258205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYV7"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31263" checksum="F3A7BFF17DA755EB" modified="2020-06-17" version="1">MADQKITEKVRQTAKEEAVHVRQLAEQGAKSGAYLYPLRGIVYLLSHEDLRRPLISRLASTFTLGMGVTTFMFLFTYVPQVAALVFTSGPLAALTTILLVLSESSTLTTVLSRALLIDESLIDTFDGTLVSKGETTLVAKERKVASGRTADSIARLGKLVKKPFQRFKPEAIVRYLMYLPLNFIPIIGTATFILLQGKKYGPQTHNRYFQLKGMSRSQREQYIQENQGAYTSFGVVATLLEMVPIAGIFFVFTNTCGAALWAADLEKRGGTAPRLRENIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYW5</accession>
    <name>A0A6A7BYW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_287505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYW5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="26881" checksum="141F4FA4DACCC89E" modified="2020-06-17" version="1">MRALYLCSIPSERPSGIMWLDTLRAKPVTEKNSRHTPNLKKNDGACWAWRITGRDLLVVDRAVELVIMQDEIIGGPNAEISGVCPVPGSAKLLEVFLQDSDNVASEAICKRWLVGQLHATCLHTACLFRGLITASLWYTVTNSWPLTSFLHFSQHTSPEVGDFHEQLLERKVDHNLLFHVTVRSLLPFPPMRSASRLLPFHSLLALPFLRRRYSMHHGVRALSQGIFPSCRYGFGNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ85</accession>
    <name>A0A6A7BZ85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinal pigment epithelial membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_258052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ85"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="658" mass="73203" checksum="E586EAD313C47086" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ87</accession>
    <name>A0A6A7BZ87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ87"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="129" mass="14821" checksum="35B9EA44C91E8F63" modified="2020-06-17" version="1">MDEKHVEVSKKLHAAGLEVRCVQAEMKCVEKSKNELRKRLSYAKKNYAWEIESNARAAREGKKVAELTVQLESTKILLAEERRERAKLQKEQKTQATEKPATQSKEKREPIGKSPDRTTYGFDDEMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ98</accession>
    <name>A0A6A7BZ98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_67403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ98"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12442" checksum="836F364E98F18A1E" modified="2020-06-17" version="1">MFFAHDAFLSKFGAQYLVPAVLAKYIGELCCTQGRFYDASHWAHKALAGYEHVLGQSHYATKATLEKLEHLDSLLCIEPSTGDSSQPVRIVWAEGGVGFEGSRRLEVRVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C043</accession>
    <name>A0A6A7C043_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-phosphotransfer domain, HPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_257426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C043"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="22393" checksum="D6E64659FA8F0144" modified="2020-06-17" version="1">MSATPKADKPVQPAAVSKPNATTKAAETKTADSDPKSPDEDASSTPDFGDLVDSAAFEQILEMDDDDEREFSKSIVYDFFAQAKTTFEKMDKKLEEKNLAQLSELGHFLKGSSAALGLTKVKNSCEKIQNYGAHKDMTGTKEEPDDNVCLKQCKTTIEQAKDEFKDVQAALRKFYKDDGEDEPDEPDEPDEPDEPDEPDGQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0B4</accession>
    <name>A0A6A7C0B4_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_231757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
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    </dbReference>
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        <property type="entry name" value="GRAM"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="1170"/>
        </location>
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            <end position="424"/>
        </location>
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        <location>
            <begin position="910"/>
            <end position="1075"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1330" mass="146947" checksum="1BD15287CF4384D4" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0J0</accession>
    <name>A0A6A7C0J0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">K470DRAFT_257362</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="323" mass="36759" checksum="78FD9D720583A476" modified="2020-06-17" version="1">MAPKKDNAPKSAKVAVDKTFGMKNKKGGAAQKQIRQIQQASSAAKTPEQKRKEAEKAAREKEKEAAEQARKEAAELFKPVQTQKVPFGVDPKTILCQFFKKGACDKGRKCKFSHDLDIARKTEKKSLYTDTREGEATEDDKTKKDDMADWDEEKLRKVVLSKHGNPKTTTDKVCKYFIEAVENQKYGWFWTCPNGGEKCMYRHSLPPGFVLKTKEQRAAEKALMEKSPLATLTLEDFLESERHKLTGTLMPVTPETFAKWKKERLDKKAAEEQARQAKEATGRAMFERGDWEVSEDEDDEDDAWNLDELRRETEEAGEEQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C119</accession>
    <name>A0A6A7C119_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_56475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C119"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="234" mass="25638" checksum="F731A22A2B86963B" modified="2020-06-17" version="1">MATKMELNSKDYDYTVDSSALLQVPVSFRRALKVFLRTRGMYTGRNREDCHTAGVPTHFAGTTGVGRQGVCGHILRANLEILCQETQCFHHSVVRKPLLRTTRESQPTFTYRQPILTTLNLNVTTLSVSALPQAPSRNAPCPAIPQHGLPPRPRTPSEYMPPPPMARSNAPAAFALPYNASTGQLPHRYASYLDFPFGNVPPLDAPNTHVPPPAAPKLQEPPPLVSPPLVPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C188</accession>
    <name>A0A6A7C188_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_56718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2860997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C188"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025694049" evidence="6">
        <location>
            <begin position="16"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="426" mass="45709" checksum="057AB7F71B3F0C1B" modified="2020-06-17" version="1">MLFHQIILFISLAAANPLPAKQHFNSKFGTIRTLSSTNCPLTELVHTTKHIPLQSTKQSSHASRALQTIFRPTNGTAPLVATAENSGYSTILNFGGKDYSVIFDTGSSDLWLASSSLKCIGRFHDSLPLSSCNFGPLGPATFTGGQIPNENFNVSYGDGEFVTGVMGREDICLGGVHVANQTAALVTTAFWQGDSSTSGLLGFAYPSLTSAFSGSDPTHDLRGKNNISYTNFIFTAAGRGLIPPLFSLALDSEGGALSLGGLPPGVSHGNFSTTDLKIYNLFNLPRPENTYTYYTVDVGDVSTDDAHAGRDFPAIVDSGTTLSYFSAEVARNVARAFEGSVFDALTAMWYVPCNASQPSVTVKLGKGRFGFKEEDLVLQNSRNRFDMCVLGIQEMDGVHILGDTFLRGVVAVFDIGANKMRFAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1F1</accession>
    <name>A0A6A7C1F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1F1"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="221"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        </location>
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        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="582" mass="65584" checksum="A63C8DA00627BAD9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1U0</accession>
    <name>A0A6A7C1U0_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Phosducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_294204</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="27082" checksum="43C0ADDEAA6C8610" modified="2020-06-17" version="1">MDMPVNVPVDDPQADTEWNDILRKHGVIPEKPPSPTPMIEEALTQARQLAHENRLEGKDLDELDELEDDEDEEFLNEYRRKRMQELAELQAASVYGQVYPLQKPEYAKEVTEASQKTFVLVLLTSSSGANQDSQRMAELWRCLAAKFGELKFCQMQANLCIEGYPDRNTPTILIYHNEQIKRQIVTLKELRGTGTNVGDVEKVLVAVGAVKLGDKRLEGKEQDSDQQQIHDNGIDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C228</accession>
    <name>A0A6A7C228_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese and iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="320" mass="35927" checksum="D01CFB8DD5CB4961" modified="2020-06-17" version="1">MIPRQLGRPLAAFAPLRYTGPSCVTLPSASFVSPRRSLHKLPILDQDNMFRRHGIANFISPEAYDMAWTQYQQQTLNKLNDLLADDPLEHIKIRSVILQTAHDPMAAHIFNHASMAWNNHAFFSTLSSDPKKLEAIPRLQESLEVTFGSIENLKMTMLDTAAAMFGPGFVWLIWSRDLEPPTSRIRKGSWRILTTYIAGTPFAEAGYRQQGLDTNTNNSTTMKNYMNSPPINNVGAFGAFSRSGKEQASLPPGGANVLPVLCVNTWEHVWLRDYGMDGKRAYLQEWWNAIDWHAVDNNTPPEAKSALQFIRGDDKSPLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C2</accession>
    <name>A0A6A7C2C2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_245444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2C2"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="359" mass="40125" checksum="DEEDA46E6BD94BF3" modified="2020-06-17" version="1">MDIHKEFLAWASAQSVKLHAVHPEHIPDHGIGLVTTGPIKKGDQILHVPSSAMFSSQKPLAKEASPQAQLAASIIISPPDEAWTRTWPAKANLLASLPLFWLAEGQEQLPDATRAVLQRQQRGYERDTKDAAAAGIDVLNNDWDYAWAIVNTRSFHLGKKDMVLCPVTDYINHSPAGQTPSAVAVSQGKDGYRVLATRDYDVGEEVLATYGSHSNDFLLVHYGFIIPSGSYDDNVVLDQFLLPHLRSETRDALQMVGFLGSYVLLPTTEMRWELCFRAQVALRAELSKNDEEWGHFMQTGEDLNAALESKVVKFAKHLTTDFVKHGWEKVSMLESKGAREIVIERWKQILTILTRWTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2P6</accession>
    <name>A0A6A7C2P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_263427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2P6"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="223" mass="22391" checksum="2AACBFCCF13C95DE" modified="2020-06-17" version="1">MTTGYGRITTSAGDYASTDVSGSSTLSDQYSSIVSDVAYYSSMLETALPSSLLSLISADPEAAISEISSELHASTGLPSWFTHLPTPLQSEILFGVDGYASITSLISETFAATATGFTSEPTEISSSETKSLDYGSGVIASSDAQTLTASSDVSSSADSSGNSSATSNRNGDSSNIRTSSPSPSTSSTDNTGTQSSSAMSLGSIGTFVAGFAIAVGIGGVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C308</accession>
    <name>A0A6A7C308_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_276322</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C308"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025619800" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="540" mass="60603" checksum="6158728180D0DCAC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3B8</accession>
    <name>A0A6A7C3B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_26692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3B8"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48363" checksum="3EDFA4FB713301BA" modified="2020-06-17" version="1">MSTSAMPSTVSSGERRHHWVPAILLLLYLVFSITLYSICNQQALRVVWFVYLTISTLVTACMAFEAYDGNTLINDARKSLNNVAESAREAAKDNCLPSMHLIFDTNNASFAQNVAKSIDYPFDRLFITSLCQSGDFTAGGRTTYLTCTAQEVPERVAFCLNQNVPASDCQITAVFAGDQLPHPYAPRLAGQRMLQNENLDMIQGRSLLTSPGRTSVVSLLSILRQDMMHALLLPGRTLTWNVKVPYGTNAYWKTEALRKAAIGKDLSWTPVSEHINAIWDLSIISFSRCALSWGSLGSAMIYDAQQATLASLRYTKLVFSKRRPIKSRIGILYMLMLLQITAHAVLQFFCMALCMLIVHAPTSLASFTHMIHWPAAATKWFIVIGLVSMICTAVMTYRVRSEAVPLWAGVLFLIALPWLMLLQAAADVFAQLALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3C0</accession>
    <name>A0A6A7C3C0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_285197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5132737at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="19936" checksum="51E4C15D0DA8B8BA" modified="2020-06-17" version="1">MSEPSNPRKRPVDPITTVGPDECKRAIEMLPSDTKSLINPAELQKLESWAVVEMQIEVSLCSSSSPMGQESVVQWERRIGGKIPKPDFAYGLQKTAFDKNVWNQLDWYEKYRPTRFTRGGLYFPFFVCELKAKDVSLDHAHVQACSAAATMVDAVRQLCQVTKPDEVDSLEGQILGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3H3</accession>
    <name>A0A6A7C3H3_9PEZI</name>
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            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_200930</name>
    </gene>
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            <taxon>Capnodiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
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        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="155"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="47019" checksum="4F0C062DC133F417" modified="2020-06-17" version="1" fragment="single">MDTRTPSPGQDAPADLSAEVATLSTKLVNAINHQTNLDDSLQSTRLELEKTQQELARVRQEATNEVAQLRQELSRERARRDEAERQRKQTEGELENLTTALFEEANTMVAAARKEVEAVERRNGQLRTQLSDTEVLLASQTEQLHGLKGVMEQLERASETERDSSLPATPVRSSAQWDADPSSPLDAPCVDVTSYPPLHFAQFLVPALRFDVAAYHEFEDLLAIGRRSGPHSRHTSGGTPSTSSPSLPGGLSFTTSSSPTPNNPSSVLTPLKDSKFYKRSLEEDIEPTLRLDLAPGLTFLSRRTVLASLLSGSLVVEPFTPQERFYSPVFACALCGEGRKDEVYLRKHRLRTNEDEGAQRYPLCDYCLNRVRVAGDFVGFLRMVRDGHWKAEGEEEQHSAWEECVRLRERMFWARIGGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3L1</accession>
    <name>A0A6A7C3L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">K470DRAFT_256969</name>
    </gene>
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            <taxon>Capnodiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="186"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="317"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="434" mass="47137" checksum="9508D0F8350CCA98" modified="2020-06-17" version="1">MSASSSLPSDYINEIRTLDRLVREDAPEDILQYCANHFLRRLESQRKEFRLSENHPTKKMADNSFPGSNNPFGAGLASFGMHSLVEEEEEQGHGLTSPTAAAFPANSRSGRPIGNAPPASLAAATVGSLEIASSIPPNFNMGRRTSVSAESLAPAAADDAGWKAPNYPKTAEQTARLHEAVSHNFLFAHLDDEQSAQVLGALQERKVPAKDVRVIVQGDAGDFFYVVESGKFDIYVNPSGAAEPGPNGLGKKVAVSGPGTSFGELALMYNAPRAATVVSTEPSILWQLDRVTFRRILMDSAFQRRRMYESFLEEVPLLASLTPYERSKIADALETKKYPAGSTIIRQGDVGDKFYLLESGEAEAQQRGRSAPLKKYTKGDYFGELALLEDKPRAASVVSTTPVKVATLGKDGFQRLLGPVESIMRRDDPRKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3P0</accession>
    <name>A0A6A7C3P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF410-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_214063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3P0"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="35685" checksum="B8A8ED4CA9BF2390" modified="2020-06-17" version="1">MSAKIQKVIERQKAKIEEGDYYEAHQQLRTVANRKVKSGDFTSAIDLLSEGALLLLQAGQGGSGADLCTYLIDVYQKAEIKADVAAKARILGLLRAFPPNEPVKKKFVAGIIEWSAKQSEFPAGDPELHHVIGKLYADEGDVYDAERHLTLGTSDSAEIFSNMEYEWYESDEPPTAPSYAARVVFPYLLVGNIRAANKALLLFNNRLSSNHPGLGVQSISSPSSDIRIYPSLPLLNFLGLLLLAIQRGTSDLFKTLKSHYSSNLKDAGWDEPLAHIGEQYFGIKIPRQSNPMFDMMSSMLMGGNNPFSPKKKDKTVAAPPAPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y8</accession>
    <name>A0A6A7C3Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_256152</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="19">
        <location>
            <begin position="1508"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1944"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2089"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1956"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2090"/>
            <end position="2112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2862170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="2232" mass="252881" checksum="94B2275AD2646142" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C484</accession>
    <name>A0A6A7C484_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_213566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C484"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025549204" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="240" mass="26098" checksum="1C8A5E0076D8397E" modified="2020-06-17" version="1">MLAAFLSLSTAHTVITYPGWRGNNLHTNGSLPQDTPSSIGIDIAENGTLSFPFGMQWMYPCGGMPLTTNRTKWPVSGGAISVQPGWFRGHSKALIYINIGIQDGNEKAPPNYSHPIVPPFQITGPTNDKYPGQFCLPQTSMPANTSLQVGQNITIQVIETAQHGAALYSCVDVTLADDHDPEIQEVTRDNCYNSSDIGFNLLFTTQGLDAEGLTNGAISRRAYSWLSWAGFMLIWAAFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4V3</accession>
    <name>A0A6A7C4V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">K470DRAFT_293425</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4V3"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 27" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="201"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="25">
        <location>
            <begin position="349"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="26">
        <location>
            <begin position="623"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF2862541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="745" mass="83159" checksum="8F10F841BD1617C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C505</accession>
    <name>A0A6A7C505_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_213666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C505"/>
    <dbReference type="OrthoDB" id="5367448at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="194" mass="22162" checksum="0A00A5F32E063489" modified="2020-06-17" version="1">MTSILRPTSNRAVHLKLTPRPSSLGESREIYRLLSQLGQIEHFSNLKYDTIPVPNAIIVIFRDESAAKECLRLSPIKLRMERLSHSSTETTLENQYLSSPSEPGPKTIQIMSNPAFISFKDQLRHAPYHGAYDLDGKRIDQRELIKSVPHAGLSVVNWRVGQRPWRRIRQERESSASFPGSGSHRKALRELLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5A3</accession>
    <name>A0A6A7C5A3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_197531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5A3"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="40"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="277" mass="30030" checksum="16F299283E688F77" modified="2020-06-17" version="1" fragment="single">SQPPREASFLPPSINRETILSGQSYTYLTSLPLGITPSTPCILGIDEAGRGPVLGPMVYGITYLPANATTLLPSAGFADSKTLSPAARERMLAALCTPNTQLHKTCGWGVRVLSAREISSLQLGVGGGQNLNTQAFEATVALIRGVMELGVHVKEVYVDTVGSPATYQKRLERAFPEIGRFVVEKKADALFPVVSAASVAAKVTRDRALEVLWEGFGGGEEDWGSGYPSDGRCTRWLRENMHPLFGWSGECRFSWGTAEQMLDSFGFEVDWGKEQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5F5</accession>
    <name>A0A6A7C5F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_213889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F5"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="210" mass="24335" checksum="2CD344AA25C7DA2C" modified="2020-06-17" version="1">MALAAPTNGLSDEEIRQIFQDVQRSGWLPKLETKSLPKPYISFGKGGVSKLDRRRMHQERTAPQMRQMERVKVEDPIVVKKRAAQEKEATAGPDWHNMPRTVDTPQLKRDWQLIKMRDVLDPKRHYKKDGKKDLPEYSQVGTVIEGPADFFSGRIETKKRKRTFVEEVLAGEHETGRFKRKYNELQQKKSSGKKAYYKALKAKRSGGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I4</accession>
    <name>A0A6A7C5I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_243331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I4"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025526940" evidence="3">
        <location>
            <begin position="20"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="872"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="944" mass="106142" checksum="5A7C984655DED58A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Z5</accession>
    <name>A0A6A7C5Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_200243</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Z5"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="761"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="728"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="736"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2862860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="810" mass="91098" checksum="82D3552091E878DD" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C601</accession>
    <name>A0A6A7C601_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_153793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C601"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="36250" checksum="5DF6D43C9C938499" modified="2020-06-17" version="1">MSEQLMERGVLEGHSGWVTCLATSLQNPDMLLSGSRDKTLIIWNLTRDDPNNYGQPKRSLHGHNHIVSDCVISSDGAYALSSSWDKTLRLWELASGATTRRFVGHTKDVLSVSFSADNRQIVSGSRDKSIKLWNTLGDCKVTITDKGHTDWVSCVRFSPNPQNPVIVSAGWDKYVKVSCFSLLRLVWGLATCRLQTDHVGHQGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNAGDEIHALVFSPNRYWLCAATSSSIVIFDLEKKSRVDELKPNFDLMMGQKSRPPECVSLAWSADGQTLFSGYTDNKIRAWGVMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C656</accession>
    <name>A0A6A7C656_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_255653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7C656"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="411" mass="45834" checksum="967C6BD6513FE75B" modified="2020-06-17" version="1">MNPRSLLPRANVCSHVSWKSSRAYSIQAPDAADPRLRAIDLSKLQITKTTTPKDVLPNHKLVFGHTFTDHMISLEWTAKDGWLAPHIKPYQNLSLDPATCVLHYAFEAFEGTKAYKDKQGNVRLFRPDKNMARLNKSAARIALPTFESEKFIELIKKFCHLDERFIPSERGYSLYLRPNIIGTQRTLGVGPPGSALLYMIASPVGPYYPTGFKAIALEATTYAVRAWPGGVGNSKLGANYAPCVVPQMKAAQRGLQQNLWLFEDIDPKTGRQEDYVTEVGTMNLFACIKGKDGQPELVTAPLDGTILEGVVRDSILALARERLVPEGWKVCERKFTMREVAEAADEGRLMEIFGSGTAAVVSPVRSISWRDRTIDCGLPADVEVGKVTKRMKDWIEGIQYGEEEHPWSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6S7</accession>
    <name>A0A6A7C6S7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_256033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6S7"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="513" mass="57187" checksum="20F24AE9AAA030B6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6U4</accession>
    <name>A0A6A7C6U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6U4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863160.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="8795" checksum="A41F9A8D9ABADE09" modified="2020-06-17" version="1">MVIPWVWFTRRARTAYARAFCAGAHEYIAGLLALYSFHTRQYLARTWVMHNSSASHHRIPLTDDRHPDNVSPVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
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        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="10318" checksum="29AADB6FAD907DBD" modified="2020-06-17" version="1" fragment="single">TNKPDLASIALLLVVIVASLKILDILWQTVKFWVRLARRIMFWSAVAVLALWFFARGPAGVVEDIWYWKQEWGREYQGWKEQERLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C709</accession>
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            <fullName evidence="2">Ubiquitin-like protein</fullName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C795</accession>
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            <fullName evidence="2">Autophagy-related protein 14</fullName>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="non-terminal residue" evidence="5">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="544" mass="61586" checksum="76FC2B1904FE7A46" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7B2</accession>
    <name>A0A6A7C7B2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_298057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005961">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21376" checksum="AA0B67D49C918414" modified="2020-06-17" version="1">MAERPASPTAEDREKARVKEREEQAQLPYKWTQTISDLDITVPVPGNVKGRDLVVTLNKTALKAGIKGQEPIIEGSFPHSIQADESTWTLETTTEGKEISIHLEKVNKMEWWPHVVTSAPKIDTSAIVPENSKLSDLDGETRSMVEKMMFDQRQKEMGKPTSDEQKKMDILKKFQAEHPEMDFSNAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7E9</accession>
    <name>A0A6A7C7E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_274570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7E9"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="293"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="763" mass="87288" checksum="B7B68D4B47049C04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7G3</accession>
    <name>A0A6A7C7G3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_292891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7G3"/>
    <dbReference type="OrthoDB" id="5427526at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="323" mass="34751" checksum="22A9556A017E54DE" modified="2020-06-17" version="1">METPPLSPVRSAETSPYTGRRRRRTSSSNFSACSRRNRYSDVSSQAEGVRHLSGGNLADELDQLSSCSSGGGGEAEGEAEGVAESEGKSEDEDHEPENRQESRDSSSSSSSFSSSVFPPGDFSPSFEESLHTLTLLAAASPDPCISQTTSLLHDLPPSGSLETALSRLTTSTNSLSTHLLSQSKALQGTCARILGPFATLSLSQDAARELSELVEGLVASLPLPDPGPLRAVKKFEVESGRLLELLGQVTDSLQMGRQAANAAQRQLRVTRKMVEDLRRETDEVERAWEGLRESGMEERLRLRCGERECRTLLEGLGVEGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7G5</accession>
    <name>A0A6A7C7G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_207467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="355" mass="40986" checksum="3B376992B580B979" modified="2020-06-17" version="1" fragment="single">YHHVYTMTCSADRDEPPSYVVAARQKPPTDDGSVVRELPEYTSTVNAEGVMLYQTESVNPLHGMTCGEWREVYVVLRGTLLILYRTKDGRPIKRIKAYTLQHAEIGLAPDKQHSVLKPLSRMASLIPVAARRKAWQAEPHLFQVARQHIVRLRVETNQILLAHSSEQFIHDFIQALSSGIDIALPIDDRSAPRHFTLPRRRRRRQPDAQNLNDPQLLAEQEQILRNMYPAFARPDGETGEAPRLEREVDELDLDTMREEVEEAPQEAALVLEEDMIHSTPVSNFDPTTGKWQPPHPRTPAQQQRYIRRCMPILTCDARRASDVLISRGQRCIINWQERTLDRWWMSPPGYWGHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7H5</accession>
    <name>A0A6A7C7H5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="429" mass="47364" checksum="D7BAC7F89AEE5D83" modified="2020-06-17" version="1">MPNSQFPRNTNTRSNAWPGGRGGARGRRKGGRGGKRPLVEEAQSVPNLKRVRITAERPSANTHDSYEEFGYVDGEVDKDYEDNDHSVDEDLIDDEIRDDLCHIGNANHVDFVEDVEDGDNLTEMRANIAPSVTHPTPLPKSVSIRRVTAPLGLSAPRAPPAGTPVPSMSDDPLGIAGSLSQTARVRPSRPTMTTADAVSRVRAADISSPFLLEDVVEALPNVALGLVTMNKELHIRLQALEAWVNEMHKTKAAEGGICAAMRQLLFWKHARGALWGDNSAVAAELRSRGVMAKAPTQSVLSEISQIKSDLRQDLRKRLRDVHEETLLYSVFTALHLQPVPLAFNVSEEQAKAASLWKWKVSQCSASRADLEQWDLSYHLLSTDDKRLIFERDLQRHGWEKKGDGGRGLPGRQGPRRANHLISNSWTSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M5</accession>
    <name>A0A6A7C7M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="256" mass="28588" checksum="171CF46C726344C6" modified="2020-06-17" version="1">MQLQAILKALRVCPTRKHYIRSISVPFHLDSFETVLNTKLSLSQAPKLTELTIRSPYYCMEDEPEVDFPPFYKGTVLSQWLFTLNELIGPEPNPDWQVSSTLNALNLHLIRLASPMDNPVVIGRLSAIFALPTLQHFKIPGAAFLAHSCLDVAVAKTPLKHLRLGEVIIGDDALKAIIKYPAAHEPLVPVENNYNDSIVLSMLHTNNLLWGDANRFFDSLAEKINLVEIVEPICAKVDGLFKDLVDCAQPQGFYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7X2</accession>
    <name>A0A6A7C7X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_280384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7X2"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="402" mass="45066" checksum="D36F217210C15EFA" modified="2020-06-17" version="1">MCNPRPAALIAIIGCTGTGKSDLAIHLAQRFNGEVINSDATQLYHGLPILTNKLPRSAQHGITHHLLDCIPLTSPPWVLGEYCSRARRIIDQISERGKLPILVGGTHYYIQSLLFSNGTEGELDAEDDGREARAHDDYTPTSALLAELQALDPVQAAKWHPNDRRKILRSLEIVRATGRPASDIYSAQTTSPVYDSLVLWPHARREPLRKRLDARVGDMLRRGLMDEVRELGRFADGRDTTRGIWIAIGFKQFFPIAREGSQDEAVLTRAVEETQFATRRYAKRQETWIRGKFWTKVNEARMRDKFFVLDSSDAQGFRDEVCGKAEGVVDAFLKGEALPQPKSLSPFAGEVLADLGTREGKGRKEGKNHCPACNVTCVVEDQWKAHLRSKRHKKLVSLALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C857</accession>
    <name>A0A6A7C857_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_80786</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C857"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="200" mass="21974" checksum="192B6EA8FF5E68C6" modified="2020-06-17" version="1">MCMKIHRSKARRQKKATRSPQNGCTCAIIYCQPILALGAGTLPWSGKSLGRDPTATILTWVRIEYSHLYEDHAHWTGRGSARALLPFRVQITRGVGAGRLQSLVSTDLFLKRPKVDAPLTPSYPDTPDRPQLPANHPTAIKNGRPWSGRFANATCTGGTADGPRPSVYQFRHILKGFDRPSCWIKQTGGCRSAASTLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C875</accession>
    <name>A0A6A7C875_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="95" mass="9645" checksum="5C1E33A9C1115B5F" modified="2020-06-17" version="1" fragment="single">MYSTVFSTALFAILAAASPFPSEPTATAASTGTAPPKCEITASIAWPGFCLEAVPSATGTSTIDCGGCDVKTIVADYPWNAKFACSSLQISTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C898</accession>
    <name>A0A6A7C898_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C898"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="461" mass="51422" checksum="0CD541C4D98FC519" modified="2020-06-17" version="1">MPQPPRASRYKTRNIIQHTDSKIDTDDPPQGPVEPGRPMARLTAPVPHSPPNVGYEEFVHFYVLEPEEVQPQPQVQLQQPQLPQSMMGPGRPGRPGRPPQPSVPLRIQFANEIQLIQSNVKSQAPVQISISPGRSNLKLRHYVPSSPEDAENPGHALLFRLEREDNHPAQGQSPIIQHGLQPVIPPQAQMHYHQGQQLQPLWQMLSPSTQGLPSMAPNSQQFLRLTHARQEISNVAQAQPGQATHFVAIKPKDDRSVQAQPPAQQNPQSAMQPLGQEHYNQPQQLQPVRQSQPQPLSQPLHQDIPKLTQVLRRRTPACPEPLPAPEILLINDNHPTFSQGMRLAMNEVIETLNALTRTLVNYKLIIDGKVEAERITESTNEDQITKPSETLDSNIDAQTDALLQAVEDVDESDNNSDVAMTRGDEVSEDAYYGILPSGQPDEDVISGIELTLRILRTWADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8D8</accession>
    <name>A0A6A7C8D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025472666" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="18"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="430"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
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</entry>
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        </source>
    </evidence>
    <sequence length="194" mass="20979" checksum="EBEA0976199B1D3E" modified="2020-06-17" version="1">MDRVPTASSLSTLKPREASLPTSLPSQPTPFPRPNLGGSGGGYTNLPPPLLRSMRECFSVLDSENTGTLTPERIKPILEQMGMDSSPSSIKEFFPPGAPQEVNLARYLDFLAGAMGGVSETEELLAAFEAFDEFDEGVVEVGELKGALLREGQLGERGVDAVLNEFNGRKGLKREVFRYRDFMVGIKGGGENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8T5</accession>
    <name>A0A6A7C8T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_106161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8T5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="279" mass="31957" checksum="113DFCB61E6486CE" modified="2020-06-17" version="1">MPLTTKLGDVNHADPFALEEELVKRFNALPRGKNYRTGEPNNWNFSVRYAPGCIYCRMVQLMHPQCHWSYQSGIVRTTHLPLCKKIQARVAVILLLKAVVDPIDSVQSPKAPPMEKEAPWMWASGDIMVIREMEKHLRRLGVAKELCTIHQITKSHQRKMDNDWMTLVMVASKHPISPMLLKYCGLNRNYKCCYCGVIDEQGMTIKVCSRCCMGYYCSQECQVAHWPEHRKFCHDGGSFLQCGIYAMNYSQQTLVGKNLVQRLNLNIPTGRISRHSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8V2</accession>
    <name>A0A6A7C8V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_254952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8V2"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="203" mass="22860" checksum="47A6058ABD752F10" modified="2020-06-17" version="1">MEVLLGITGKDFCLVAASKAAMRGASILKVNDDKTRELNKHALMAYSGEAGDTVKFAEYAQANIQLYSMRNHSHLSPSEVAAYVRSELAKSLRSRRPYTVNLLLGGYDAIKEKPELYWIDYLASCASVPYAAHGYAQYYCLSTLDKHHHPDISLERGLEILRMCTDELKRRLPIDFKGVIVKVVDKDGVRELPYEDDKQVYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I4</accession>
    <name>A0A6A7C9I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9I4"/>
    <dbReference type="OrthoDB" id="3532430at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119373" checksum="1D97A8E5856F11C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA34</accession>
    <name>A0A6A7CA34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_279801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA34"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="235" mass="25399" checksum="9253FD081036482D" modified="2020-06-17" version="1">MFTGIVEAIGTVSRLVQHDESSSGGGGTSITISNCASILEDAHLGDSISVNGTCLTVTEFSKDEFKVGVAPETLRRTNLGLLKQGDGVNLERAVSANTRMGGHFVQGHVDTVATILETREDGNAITFRLQPRDKRIVRYVVEKGYVTLDGASLTVTNVDDENAWWEIMMVAYSQSKLVTSKKRKGDDVNVEVDMVGKYVEKSVAAYFKSGDGSGSAVLQKMVTRMVDERLQASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE5</accession>
    <name>A0A6A7CAE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_254139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAE5"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19824" checksum="D466EF557AF911F0" modified="2020-06-17" version="1">MKPQWMVDLATPPPTKGKSAALPDPPGFISQSHRGGKVNKNVATPRKQPSAEEMDTLKIKKAWELALAPAKQLPMNAIGMYMSGNSLQIFSIIMVFMLFKAPVQAIFNMQSTFARLETETNRQQMIVVKLAYIACNMLALALGVWKINGMGLLPTTRSDWLDWEMPREVSERVVYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAP0</accession>
    <name>A0A6A7CAP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_253997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAP0"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="487" mass="54344" checksum="F3A616B075C271FC" modified="2020-06-17" version="1">MAVSVSESTHQTSRYASVPYFPQRITEPLTPTFSRSISSQVDPPGGYREEEILLYELTARYVSSGFAAERRPRCIIRFGPEPKRRAGDYWVWDSDCKESDAKIGDADWGKDYELYRTNVRETDLALMEAKLERALRQMHTDYLQLDTKPRKAVVVVPPLLPRPLLETFLGVLFNHYALTPSVVLFSTPALSVVSSGLRSALVVDIGWEETIVTAVGEFRQVSQRRSTRAGKMLTAEMGKVVRSHSQHADLSFKLVEDILDRLGWCRPHADTPPLQGTKSIPVASSGTSARFDMRIQSLSEPVERVLFGNPKHADDDELPIHYLAYLVLLGLPVDFRAACTYSVVVTGEISQLPGLRARLLNELQALIDLRGWDLVHNYGSAKPKPKAAARSPSSDHQATAEASYLDPQAILPPHQREHDYIKDPITQKAERASTKRSPKPEPAVVRGVETLGAWAGASLASYLRIRGVYEVSKEDFLKHGYPDNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAU7</accession>
    <name>A0A6A7CAU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_254632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAU7"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="111" mass="13024" checksum="5252C3AC984AEC62" modified="2020-06-17" version="1" fragment="single">MGFPKERNQKALRRFVSMEKNTTQRTTDPDAEEIPMEEGRYERGKHRLIISQNFMTQVARECEKTNHHPEWSNVYNQVNVTWTTHRPRGISMKDVRMVGFCDRVAGDVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB01</accession>
    <name>A0A6A7CB01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_239060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB01"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="23678" checksum="6557C663437BFA1C" modified="2020-06-17" version="1">MAGKKAATENSKKAAGAARKAEAASRKSAAAASAAEAAEAAAWQQGAKDTRKADAAASKAAEAARKKAEKEALLKEEEASLPTKGGKGKVPPTKKAKGLDLSGLDTPSSSAALNASGIDNALDALALTAGQEEKVERHPERRFAAAYKPYEERRLEELKEEKGLRRQQKIEMIKKEFEKSPDNPFNQVTARYDTSKEEVREMREGVRRWKEELLTQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCB3</accession>
    <name>A0A6A7CCB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_208239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCB3"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="919" mass="102679" checksum="2E4E258DA3B5DF35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCC9</accession>
    <name>A0A6A7CCC9_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
    <sequence length="397" mass="40836" checksum="8318BB3C4A087C2B" modified="2020-06-17" version="1">MGFIRQVLPVLAIVSQAVAGPCSAATATIQNAGDASQLASCTTFSGSIAIATGTTDSIDISGVRAITGSLIANNVTQLTSLSADSLQTIGDTFSLNGLTVLANLNFPQLTKVDTIDWTALPALQGLSFSTGVQQANQVSIQNTQLNTLAGINLETVTSIIIANNNYLDEINMQLGNVTERLILEANGRNVSAIFPNMMWAYNITMRNVSTVSTPSLASINGSMGFYANFFDSVAAPNLTTVGGSLSFVSNANAQNLSFPQLKKVGGGLGVQNNTALKAISFPQLQSVGGAVDFYGNFTDVALPKLSDVRGAFNLQSSKDITNACNHFKPLSGSNNVIKGTYTCSGGRSRPGGTGTLSPGTNSGNSGSQQSQSSSATAVYVSSGAGIMSVLAAVFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BNV0</accession>
    <name>A0A6A7BNV0_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_279543</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Clr2"/>
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        <property type="entry name" value="Clr2_N"/>
    </dbReference>
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        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="24042" checksum="A0E12234876C432A" modified="2020-06-17" version="1">MYVALVDINNCSDGDPAKRPAILPNVTRNDDWWCEQLGEMWAASTGRGPRPDVKFRLTRLPAGYAGFDHVHAGGRTERAIWGHPRGRIRSPKAFWPHFNWLQDDTPSGGGECPCERCNGINWREKQKLRAYAKTAVQNANFALRADLDQRLVGGQRAVGYQRSVEGENNGGEEDTYVEEDDDDDETDNEGNDDDDDADDDPEYEEGEGRKENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ51</accession>
    <name>A0A6A7BQ51_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_261161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006077">
        <property type="protein sequence ID" value="KAF2857057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ51"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025331228" evidence="10">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="306" mass="34039" checksum="E02C45039818B399" modified="2020-06-17" version="1">MPKSPLFLAFFSLLPPWTSLSRYAALDLVIAHCLCKIVKSGAAYSSLLYTYPRKDRSWSPISVAAVYIFDPLTFDACEERPYRAAFSLAVASYIGLHSLLLVPPVGLLCYDRAKKRLDAVVFGAKLAYLFKGTIMFLLLLSRCLLPLLGLSGIRLPYTLDDARSDAKPRSMVVLFIEILWLHMLSYSVPFTIRLKKQQLAAAIMMLGVIAVFQPYANIAATGAWLSSLTLLGHAFERAFPRAQLHLPALATLSRCMFLGPAFHSSWMDAGSGNANFFYAITLVWSLDLLVLLADAIYAVVRDEWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ96</accession>
    <name>A0A6A7BQ96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_279277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ96"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="449" mass="49491" checksum="179C062992EEBD65" modified="2020-06-17" version="1">MGVVKSARHESEDVSPSPLGKPLKFEFSGVSAPNRFLKGSMTERQSSWDPKKLEARGVPSKELINLYRRWGEGGIGNILTGNIMIEYDQLEAAGNPIITRECEPSGERFERFKELAAAAKKHGSLIMGQLSHPGRQTSEHLQPHPISASDVQLMGNPLGLSFAKPRPATEKDIARVIDSFAHGAQYLEKAGYDGVELHGAHGYLLAQFLSQTTNKRTDKYGGSIDNRARLIVEIAQEIRKRTQPNFVVGIKLNSVEFQDGGFTPEEAKQLCGLLEENRVDFVELSGGTYEKLAFLHQRESTQKREAYFLEFASTLTPALKKTRSYLTGGFKTVGAMVHALDTVDGVGLARPLCQEPHLCADILTGKVKGAIKMGVDENDFGLTNIIAGTQMKQIGKDKEPIDMSKSENVEAFKKDMGKWMEKMSKNTEGIHYGYVDIESSQPVPYGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQQ6</accession>
    <name>A0A6A7BQQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_19681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006067">
        <property type="protein sequence ID" value="KAF2857105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQQ6"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="208"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="353"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="431" mass="47609" checksum="8160CBF52E9676B0" modified="2020-06-17" version="1">MLGEDLLDEGGAKGVNGDVPRLELNRERLELPHIEDDEDPGWEIVLRRWRGIAHLENNLSWAPFPLRLAFVRPTEVLNYDEEFLSRIESFGEVGLDSLPNPCLTEEDVEDVKTVVGSEQPDRMHQLLQKRKMQFSQTQPPKKPRTDSSSLLDQGLSNFIKIRGIVEKTPERQSKPVKKAAPIPALPRPETDITPFPTPALANASRDMQIVVSTSIAAQRSTMRQLKTLLPGLDVIERDSIIDADITISPSTGLIMTTLAKIKQRSLPGQAARQVSIRERIAAIALRYEKLVILVEGSSSMDEHDCMAWGDFLGYTAILDAAVQVTHVASEPVNWMATYILLHSTADLGVTLLPEETMWERFLRAGGLNSWAAQYALARLKDQPRPGLAAFALPVAECMQRLVDVVGKRVLRHSVGAMTSSSACTATTATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQZ4</accession>
    <name>A0A6A7BQZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006060">
        <property type="protein sequence ID" value="KAF2857185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQZ4"/>
    <dbReference type="OrthoDB" id="10373784at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057895">
        <property type="entry name" value="Mom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25680">
        <property type="entry name" value="Mom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="29732" checksum="C757BD60D4C6B599" modified="2020-06-17" version="1">MITDRSQRWRDRRSRFVADDTVIDPRRYAVDVVAHDTARAFIADHHYLNRYPAAQLAVGLFGPGRGGASSLDGIIVFGVPATGAVITRHTGYDEPTRGCVLQRLLCLPSVAANGESYFAAWAFRLLRQAKPVIESVVSFSDPQVGHCGCVYASLSGAYRGRTRPRTVLRIAGETISDRTLSKIRNLETGHAGAVDQLVRLGAPRPQADEHLREWLERCRRAEILVPARQAPLFTYCFELTRGARRAGRALPRLAYPIRSDILREQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRB8</accession>
    <name>A0A6A7BRB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_160072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRB8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11344" checksum="9FAD035A31A56C57" modified="2020-06-17" version="1">MNRTSRQQIPSFTRSTWILLKDITPKLFEEWSETNRAVEAAEAAARIAEQAASAAAQGPSWAIIHADTANDFEGLDATYAVDQHVEDESGASAYHQMNPKHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRF9</accession>
    <name>A0A6A7BRF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_152431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRF9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="188" mass="21338" checksum="AB5E0E8A852A77CE" modified="2020-06-17" version="1">MLLRVLDRHCSLQTSLERHKKEEHVLGQGDASEPWAEGLDIWTAEMHWQGRPDHRTHPGSWNVQSCLVEDTSSITGSVNRRMGSPVCSRYGQIGRRVEMTRFSIASLVDALIPDHASVQKEKERGCTKSVEGKTWDSCFTGDLSSEDDAGRGPWMRMLAEAEIEEGRREECYCNQRSNDITNSQHMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRG7</accession>
    <name>A0A6A7BRG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_237608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRG7"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="746"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="806" mass="92319" checksum="2D500F00123BBB4B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRK0</accession>
    <name>A0A6A7BRK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_222536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRK0"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="472" mass="53530" checksum="3A901E69B4BEB74E" modified="2020-06-17" version="1">MGDYGDGVQTPMWKFTQCFGDKGDVEDITEADIISTVEFDQTGNYLATGDKGGRVVLFERNESKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCKRQNASHYLLSTNDKTIKLWKVYEKSLRVVAENNLPMEVTPNMGNANGGARVPNHQIRTAADLRIPRLTYHDSVVAAVPRRVYANAHAYHINSISVNSDGETFISSDDLRINLWNLGIQDQSFNIVDIKPANMEELTEVITAAEFHPLSCNWFMYASSKGTIKLADMRERALCDSHAKQFEQEEDPASRSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDINMERQPLKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDGKNVMTGSYNNNFMIYPSEPGNDTEVVLQADKSAFKAKKVGIPQPMNPAGGVKGSRANSPAGGAQRMSKETNAEKFDFNKKILHMSWHPREDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRT2</accession>
    <name>A0A6A7BRT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_222281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRT2"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="39550" checksum="D8F4CF82F23DA8E5" modified="2020-06-17" version="1">MPARPTGPLKFGAHTSAAGGVHEAPIRAASIGANAFALFLTNQRQWARSTLSEEVITQFRARCAEQKYPSSLMVPHGSYLVNLAHTDPVRAEQAYAAHLDDLKRCAALGIGLYNFHPGSNQCGDRAKAVAQLAAQINRAHDATPGSTVVTLLENMAGHGNTLGGTFEELREMIDLVKDKSRIGVCLDTCHTFAAGYDLRSPTSYKQTMELFDSIIGMKFLRALHVNDSKAPLGSKRDLHANIGTGFLGLRAFHSLVNDQRMEGIPLILETPIEVTDENGVKQTNEKGKPVEDKNIWKEEIVMLDSLRGMDVESEHFKEMETKLERKGEAERKRIMGQVDKKGKPKKTKGKAVESNSDSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRY1</accession>
    <name>A0A6A7BRY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_238386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRY1"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="37008" checksum="110159051171655D" modified="2020-06-17" version="1">MFVARNNENAIYEQQTAIAAKGGLELAPKTPGKSLKTDENAKTLAGKVGGKNDFKTPAQTRTRAPLGVKTTNAKMTAFATPAPEKGNFQRSSISPRLRRPRVKPQAVADPLGADENVPEVEYMAPRGIPLPDEPQEWPRDRKYPQFEGKNLTRGIFDRDSAGEDEELSDFEEKLRAIDARRKKSVATKAKPVGTVVAKRAASSLANVESKLINRGPSFAAPTAATKSRFLAGVKKDAPINDARTANARHVVAKAASNTTLGYSKGRAIRGATRPSTRNNSVSSIGKENISPARRDDLIGGSSTLDNLFNLGPVNEADEDELFGTTADSGEDYMADFQLSTGNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS24</accession>
    <name>A0A6A7BS24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_279386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006051">
        <property type="protein sequence ID" value="KAF2857308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS24"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="350" mass="36148" checksum="C466F7684D193787" modified="2020-06-17" version="1">MEINGDAVIQEPRFPQAADANQLSPTGNGYPPIGNVITGQPAVYMNPVATADHRASIDSILDTLPGGSDQQNRAGVAPVTAESIPPSPAPLWNAHPSQMAGNNTYHPNYNTFTRTPSNTFAASPAMSTPGNFHSPSPVSTAGGPVISPNASSPSTNHGGTLYASTGTAPMTVHAIMSSAGTTTALPTTTATAPSMPQGGTSGGTFGVLQPTTAAPSAVYPQSARATTPVYHPPPQNSMPPPQAPPPVAQPQYQQLAPRPTPPSRTPSAPPAPSPSQAPQASQTPQISPGSQTKYPSKPAAHGGPTRQYINNNVTPHLLEGMKYLAMYEPEKPLKVLAEFLAKRSKEVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS56</accession>
    <name>A0A6A7BS56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_266364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS56"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="43276" checksum="F3F24826FADB4380" modified="2020-06-17" version="1">MTHGFPYNTWDEPDPHMDSNWADNSVSRRQSPYSRSQPWTALDNDSPVHYFPSIDSTKNIDSVAPWPSLNLQAPSPRTAPSPSLPGSGDDDFRSPWLSPVVSYPTYSPDLSSEPAMMGDDLVLDCPPVCVAPHEVQPQPFLTYPPLLDDNIYPGLAGVGLQWESPALREAPSEQSSHKLSPPAASTLRRTSTNSGRVTKSGAGRTNTFHRGTPERQRFQCPFANYGCTSRFGAKNEWKRHVSTQHLHLSFWQCDQCPRPDGRPLKEYNRKDLFIQHLRRMHSSHNNEDGEDAEDKVAMRCFHHRRPPPSQSRCLFCPKTFCGPKSWEQRMEHIGKHFEDLRGTTREPHDWIVDKATENYLIDHDLVAWKNGKLVLKECGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS94</accession>
    <name>A0A6A7BS94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS94"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="477" mass="50656" checksum="82A3578E86C0E5EC" modified="2020-06-17" version="1">MFTWLVGFGSRPPAFLSFRSSKLFIITTVSVAIFTDIFVYGIVVPVLPFALTTRSGIDEKSVQTWISIFLAVYGAGLLFASPIIGWLADRISSRRPPLLIGLVTLAGSTAMLCAGSGMTLLVVGRLLQGASAAVVWVVGLALLVDTVGAAGAGEVMGYVGSSMSLGLLVAPLLGGVVFDMAGYYAVFGMAFGLIGVDAVLRLVLIEKKVAARWLPDQQVQEQQVHGQIQEEPAHDSAKVEPANANETTEVSGPSKMSHRIPSIIYLLSSRRLLSALWGCLIQASLMTAFDSILPIFVRDTFHWNSLGAGLIFLPLVATSFLGPIIGHWIDKKGPRLFATAGFLATCPFIILLRLVHHNTLHQKVLLCALLALIGLALTLIITPMMAEITYAVDAKAKSRPAGFFGKNGAYAQGYSLFNMAFAGGCVFGPLLAGLVKSKAGWSVTTLMLGLVSAATVPSTVFWTGGQLGKKEKEKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSA8</accession>
    <name>A0A6A7BSA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_260308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSA8"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="476"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="809" mass="87747" checksum="74B210A548CAD4F8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSG6</accession>
    <name>A0A6A7BSG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysozyme</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_197979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSG6"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="204" mass="22757" checksum="A2EB71708EA3AB2F" modified="2020-06-17" version="1" fragment="single">ASSRVLGWDISGNQPNINAANAYRKGGMRFVYIKATEGLTYHNPSFSKQWTSTTSAGFIRGAYHFAHGKEDPVKQAQFFVAHGGKWSADGKTLPGALDLEGVNNSVCNGVTPSWVKRFSDEYHRLTKRYPVLYFSPGWWTQCMKGSTEFSKTNPLWLAAWGSNPPTKLPGGWKQLTIWQNKDTNKYGGDSDVYLHGLAQLKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSH4</accession>
    <name>A0A6A7BSH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_273283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006042">
        <property type="protein sequence ID" value="KAF2857468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSH4"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="299" mass="33241" checksum="DBC03185B04E19C1" modified="2020-06-17" version="1">MGLSAPKQRSYFSRDPNNTAWTKSTSKYGHRILESQGWKPGDVLGAVDAQHAQHYTVATQRFVRVAPRKDNLGLGAKTGSNDTFGLAMLSGVFGRLNGKGEEFEKKVRDAEVSSYYHGRWGGVSFVSGGWLAGSRGEEVSKKAGEKGGKKRVREQETEQEQPSKKAKKGKGEKREVETDEDRKAAKKKKKEAKKAKQEADNARIEAEEAKRARKEERKKKKEAKRLAEAAEKAAGHDDDDDDDDDDDDDDDDDEVVAAPEPAALAWAGGRHAVRQRYIQQKQMAAMDPRAMKEILMIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSP3</accession>
    <name>A0A6A7BSP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_221861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU006016">
        <property type="protein sequence ID" value="KAF2858153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSP3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="535" mass="58400" checksum="C956B3C01AE02293" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSP4</accession>
    <name>A0A6A7BSP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSP4"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="8">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="362" mass="39905" checksum="9BEE20ED74EDDE10" modified="2020-06-17" version="1">MEVGSVRTMILHAQPSCITFLPNAPKYFVIGTYALDNFQEDQNSSDHEEQHDSPQTRSGTILFYQLGPKMQEATLLSWLPTDSGILNFQFSPQQPRNLLAAATSNGKIVYYTVDPTTGNQISRQNEHSIADPSTLVLDLAWHPSGNMLAVGTSDGRVILCDTITVEDVGVEVTHQRDIGMHDYSLQVWCVVFWGSSVLSGGDDSALVASSPSQDDGETKQCWKDTKIHGAGVTAILPLTDDLIVTGSFDDTIRLVNVPQTGTGRRKVLTEQKLGGGVWRLAPLYSNVKEWRILVSCMHAGAQIVRLFENQDGWRFEVLMRCTKHKSMNYASASQPKSDDVTVASTSFYDRTLCLWNGKATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT53</accession>
    <name>A0A6A7BT53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_195129</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22085" checksum="1E0862179569028F" modified="2020-06-17" version="1" fragment="single">GTTGHADTTVDQQVNPAVEHEKITRKHEDREQTVIDQERHKHHYHTTVQPLKDREVEAAQHEHRQEETQYRNIDKDTGDAKGEAEKQQAKFGNTSKEGKTEYSTTKEPTVHQGGSVHHHLHETIQPVIEKGMLYCVFRFGISLMRCRAETIKPTVTHTTKPIHETITEKSENHGITRESAISVDEFKKRLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT64</accession>
    <name>A0A6A7BT64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_289506</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT64"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="18236" checksum="E0D51DC111559A09" modified="2020-06-17" version="1">MSLVSSPSPPRVLLPRPLQSPVWMPQLRRVAATYTPRQIDLPEMNPTVTNAQYQSNALVPWSHELLSAAADVVQYSTSCYRELLHHGSDEEITQAETEMQAALTMWAAIDERSLNDAMAGLERTAPYPVAQPASLASPWLPRQLSRLRRPSPQQINASYRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT85</accession>
    <name>A0A6A7BT85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT85"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="639" mass="71481" checksum="DFA789C69B9D876C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE1</accession>
    <name>A0A6A7BTE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_260480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="25572" checksum="5A9A38217C1F9E77" modified="2020-06-17" version="1">MSPPRKALIAVTSAHAPLYRDGYETGLFITEALHPYNVFTSSGFDVDLVSETGTYHVDWLSQTPDWLKGSDRTIWEDKTSAFRKSLDKGLKPSDLNAKDYGLFFASAGHASLIDYPSAKGLQEIAARIYEGGGVVAAVCHGGAIFPGIVDSKTGKSVISGKRVTGFTTKGEEEEGVLETIQKWNRPTIEKSAAEAGAIYVSPPGPWDSFTQVDGTIVTGANPASAHATAEKAVETFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK2</accession>
    <name>A0A6A7BTK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_132244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTK2"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="247" mass="28470" checksum="7FE058E1A5F181A4" modified="2020-06-17" version="1">MPSSKGPTMPEAMRHISFGALKAAQDSLEQEKLTSQKPASEASDGDLSSDSDSSASDEDEEESPSDGPPRKKSKHAPVMLTSKKPVTRKRTVISMPKIKSRDPRFLPLGRSASAQPNPYSRNGYAFLHEYETAELDELRAEAKKYTGAERETIQRKIDSLSNRIKAREMKEREREVIRRNKQQEKARIKEGKTPFYLKKKDIKKQVLEDQFKSMKSRDREKAVKKRRVRQAQKELKRRPTERRKDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTW3</accession>
    <name>A0A6A7BTW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_222363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTW3"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
    </feature>
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            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="410" mass="44759" checksum="EE966E50CC4D97C7" modified="2020-06-17" version="1">MAEKERVSGEQERQGPDVPMLPTVNPEVEQSLPPKSSVPAAVYIAAWIALSSSVILFNKWILDTAKFHFPIILTTWHLSFATFMTQIMARFTTTLDSRKNVPMTGRVYLRTIVPIGVMFSLSLICGNLTYLYLSVSFIQMLKATMPIAVLITSWLLGVSEPSLKTLGNVSLIVLGVIIASIGEIKFVLIGVLFQAGGIVFEALRLVMVQRLLSGAEFKMDPLVSLYYFAPACAIMNAVTALFLEVPRLALADVERLGYFTLLSNAMVAFALNVAVVMLIGKTSSLVMTLSGVLKDILLVAASMLIFRDPVSPLQAFGYSIALIGLVYYKLGADKLKEYVGQGQRQWAEYGVRHPAMRRVIVFGLVLTTLFVLLGGISASGAIPDQYDPTRGYAKDKFHAVLGDSQPLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU43</accession>
    <name>A0A6A7BU43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_288961</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU43"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="187" mass="20994" checksum="424D9ECF67CD9969" modified="2020-06-17" version="1">MIQRLIWDMNFSKKTNRHKKPPPLIHTNLTYYPTTPFPRALGAQTNQLDLRTKSITNIKPNSMTPLGLSSDSPHQIKASNNLSYHPIDIRYKTPNSSTEHPGSQWREFVFSWELSKAEDVQEFSENVGGFVWAGAGTIGDESEEGIELAEVIFGDGELGPRYDDWLENAWSGVEAHGGRLVVGFGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU77</accession>
    <name>A0A6A7BU77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_128017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2858632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47477" checksum="68E3383D5F1BFB5A" modified="2020-06-17" version="1">MTSASAMMSSNIEMESASERMDFDPYHIPTEIVIEIIKHVGKNRATLLNVIKVSSVWFDIGTSFLWREPPIHALIALPPARRQYYADKIELLCTSEEEGSQGHYETKNLTFPRLEWLSIDHGVDVFPIGQYLQSSLTFLSFAGGRPEEDVLALLAVRCKNMKQLSIDDVPSYWDTDGVIAMLDHFKDLECFRMGQRLPQHIDGGRLILYLANRPKIWSLKASCDNIGYHALSRVAALGERTRIYPNIRGLELDIDWDAVTLIPAFSKNIIALKLGIFGRPQAANVFAVVGTMISVKILELHIDNGQPLQRQDLRNLAKLKNLRRMIISIRNHPATYDALADTDFTHLFLSLPNLEGIAWHAGENFPLKAFLALGLHCQRLHFCEMSARIDLLSLQQSPRICFPSLDTLKLSSGVSEENINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV52</accession>
    <name>A0A6A7BV52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_265499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV52"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="309" mass="33910" checksum="C7D5FF9CE1C1F388" modified="2020-06-17" version="1">METIRDIGLDIKGVPHTFSSWNTCMTKMYCKWPAIVGILIGSLIVLSILFCVGSCLARGGRCCCDCCSCLTRCCRGSSRPHQTVVYQQPPPQQYAPPAQPVYQSPAQPVSQSQAPPPYQAAAPPSRPPVVPVPLKSVNDDALPHMPSWDTSTSRRVEEIPLQEQQPYAGQQSHTPAYGHEPHPAAYEQQPHIAAHGQQSHTAAYAQQHHPLAQNQPAPHLQDPMDYHSGYPQQQYASQAANPMTRSHHDYAYLPNNPYGQAEVGACEDRYQAYEPQWANTRPVYTSTGGAPAQSSMPARKPLQGTLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV88</accession>
    <name>A0A6A7BV88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_300463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="17448" checksum="768DBB485C678527" modified="2020-06-17" version="1">MADADYDPEAAAELKKKRAFRKFSYRGIDLDDLLDLSSEQLRDVVHARARRRFNRGLKRKPMGLIKKLRKAKQEAKPNEKPDTVKTHLRDMIIVPEMIGSVVGVYSGKEFNTVEIKPEMVGHYLGEFSISYKPVKHGRPGIGATHSSRYIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVH9</accession>
    <name>A0A6A7BVH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_265478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVH9"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="285"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="484" mass="53670" checksum="B04FF97B069AA704" modified="2020-06-17" version="1">MAKSEKTKAASSKSKKPTKVVSLLAAQSRVDQKLSSLFATPAPIAPRVVKAAPRIAAVEGPSKPANNDVSEGGPKVVEDTEPRRKRKRRDVEEEREEAYLKRWAEAEERETDKAVKKRRKAEEEEEEKKTEEKEEEEHDTESEAEAEDNEPIKHETQEATEVELDKAARTVFLGNVSTSAITSKSDRKALMRHLSSFFGDVSDERPQIESLRFRSTPYATAMPKKAAYTRGELMDATTKSTNAYVVYSTPLLAREAARLLNGSVVLDRHLRVDQVAHPAPVDHHRCVFVGNLGFVDDESNIQDANEEDGREKRKKAKEPADAEEGLWRTFGRCGTVESVRVIRDSATRVGKGVAYVQFADANAVEAALLYNEKKFPPMLPRKLRVSRAKAQKRKVAKPQAKSKTYQRKVSAEESSRLGRAGKLLGKAGAAQMKKPEAFVFEGHRASSSSGVQGLKFGKSKKKKSGKPATRSAQRAAAYKAKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVI5</accession>
    <name>A0A6A7BVI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_283031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVI5"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="225"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="42433" checksum="9F6E98F95FE0BC28" modified="2020-06-17" version="1">MIPHTTTITTHTNPIYHNRKLPTMIKLRTNYNESVKSFDEMGPKNDLLRGVYAYGFKRPSAIHGDDVIAQAQSGTSKTATFTTSVLQRIDASAKECQALILVPTRELAQQTPKVVITIGNFINIDCHLCIGGTNIRDDMKALKEGAQVVVGTPDRVHDMVKRRILKADAIKIFILDETSPVTAPKTTQSALLSATMPQDVLQVTNKFLRDPVRILVKKDELTLEGIQQFYIALDTTCDLYETVTTTQVVIFCNTRAKVDSLSEALKSRDFLPSIMKEFRSGSSRVLIATDLLARGIDVQVSLTINYDLPFNHENYVHRIGRGGCFGRKGVAINFVTAEDKRMVRELEQFYSMHIEEMPVNVSGEFFAKTFCRAQHTNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT4</accession>
    <name>A0A6A7BVT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_272103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVT4"/>
    <dbReference type="OrthoDB" id="3439682at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="14210" checksum="D4FBDFDE088C1882" modified="2020-06-17" version="1">MGHVLRYRLYLWRVQKGEISSNEVSRNPEETILYFRDIELPLADINRLIASEIAEARHVLRRELLFGFKAPTLRPQDMWEVLEEETWASGSAWRMPRGENCEGQRTFCSHASTRAQVSESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVV6</accession>
    <name>A0A6A7BVV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-inducible SAM-dependent methyltransferase Rrg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_100962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVV6"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="338" mass="36872" checksum="7847600165F98776" modified="2020-06-17" version="1">MAMDAETGQVLDVLDLPQLYTRPPAAQLLSVLESLGSPTPSWGSGTSTPKHKTITIKSEGLPRYLTSIISSPLAWINDETLREQIWETASVRLSERSGRTAMGAISRTFVISESLFITLHEPALTADNLGLKTWASSYVLAKRLLHLKSTLPSLPTGSQILELGSGTGLVGLAAASIFKTNVTLTDLPAIVPNLWRNVQANALTGGAATVAVLDWSNPSDLSLCDRGKVSPNSFPMILAADAIYSGKHPALLAKTVAWHLKKDATARCVVELPLRERYELEREDFRIQMAGNSLVLLDEGTEMGSDDWGEQGESDITCWWSIWLWKAEVLKSYRTRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW32</accession>
    <name>A0A6A7BW32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_271758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW32"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="85162" checksum="316C086AFA5B726C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWB0</accession>
    <name>A0A6A7BWB0_9PEZI</name>
    <protein>
        <recommendedName>
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        </recommendedName>
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        <name evidence="2" type="ORF">K470DRAFT_219326</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR31573">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="446"/>
            <end position="618"/>
        </location>
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        <location>
            <position position="650"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="650" mass="72448" checksum="5BA7A584196477AA" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
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            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF01084">
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    </dbReference>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="25363" checksum="8F7BFE7F7FCD1D67" modified="2020-06-17" version="1">MPFKQALQRLSLCPSYSILRTRLSSTFSALDSLSQLEGDGRKNGSKRHVEASPTQQQQSSSFDVATRMVQKAGAPQAKRAADEAMADFQRQYTRQDLDYQMKRKWRGGDVYSPRDLSGYEMAKWKRAPRQPRPTARSGPDVLDVAGIRPIDHYKNFSIMNEFVTDMGRIKHSSLTGLRPANQRRMAKAVRRAIGVGLLPSVHRHPELLRRELLRRQEGNKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWW0</accession>
    <name>A0A6A7BWW0_9PEZI</name>
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            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">K470DRAFT_259273</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="835" mass="92135" checksum="FFB3944EDD9692A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWX9</accession>
    <name>A0A6A7BWX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_218539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWX9"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2859721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="384" mass="43972" checksum="7F8BC2F1D1A44420" modified="2020-06-17" version="1" fragment="single">RREVVKKKRLKPRPELCAEHAASTSVYYRKTGNDSVVGSGTYGKVYKGVHVYTGRMVALKKIRMEGERDGFPVTATREIKLLQSLNHINVVALQEVMVERNDCFMVFEYLSHDLTGLLNHPSFSLSAAHRKHLAKQMFEGLDYLHKRGVLHRDIKAANILISKTGQLKLADFGLARFYHKDHKQDYTNRVVTIWYRSPELLLGETQYGPAVDIWSAACVLVEIFTRHAIFPGEGSEISQLNKIYQVMGTPSRYEWPGLVDLQWYQLLRPAQKIPSTFAEKYEAKVSPEAFDLLRAMFVYDPASRPSASDVLEHAYFTAEEPTAQQVLELEHVEGDWHEFESKALRREKEKAEREARKRIAAEQQKRKAEEAAAEPAEKKVKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX18</accession>
    <name>A0A6A7BX18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_271375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX18"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <sequence length="1286" mass="137437" checksum="B89DD239D6953BE8" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <name>A0A6A7BXH5_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        </source>
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            <dbReference type="Proteomes" id="UP000799421"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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</entry>
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    <name>A0A6A7BY23_9PEZI</name>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </source>
    </evidence>
    <sequence length="1045" mass="115325" checksum="B9AFBA454085D536" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE3</accession>
    <name>A0A6A7BYE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_217553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE3"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="501" mass="55441" checksum="80D7A0BC7DA492BA" modified="2020-06-17" version="1">MAGSGSGPTRRSHTKSRKGCRTCKRRHIRCDETFPQCRNCTKHRVQCDYSQSIISDGEGTQSPDPPVTLTPGAESHVDQWQQTGKFPYPDLQMHPSPPAHQYSCTELHLIHHLSVITHQLHRNGTSHLALWTQRMPHLLSIASVHPIVMNALLAFSASHLAWVHNSEETRRLSLNYGSIALNRLHEAICSFSQADPEVVLATSMLLLWQATDWRSWSSLRSGIQSILCAMQSTNSSSPLAQLLTEEEARAVAFNTNKHTTTAPPDRIAILQDLIMATSRLHSSLPGNDMEAAWIHHLCGYVEQLRNLEAPRTAEQQFNLLYRLRKWLFWVPVLLLQAEAPQKPTLAVIAHFYAAAIALEPLFPSLGSSFCASMTLSPLEAIINLVDAPDLKNQSDISGTDMTAIMQYPRQMAAQFRSQTVQPVLPLDHTSYGYTNGVGNLSPAFSPAAPQYGTSSSYLDLPCGQSSFTLSMQGWGSQPSPAFPPPTFAMDDYSTFTASAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYZ6</accession>
    <name>A0A6A7BYZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NIC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_295052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYZ6"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113387" checksum="FC41AB02D60D3A3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ74</accession>
    <name>A0A6A7BZ74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_258354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2860009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ74"/>
    <dbReference type="OrthoDB" id="2403773at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025695251" description="Invertebrate defensins family profile domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="4">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10052" checksum="7E30A94CD139620C" modified="2020-06-17" version="1">MKFTNVFALLPVFALLAGAAPVADADDGYQISEDLQAEVNDLLTKRDPEIVKRGFGCPLFRQQCNDHCISLKGGRTGGYCSGTFRTTCTCVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ76</accession>
    <name>A0A6A7BZ76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_216667</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
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        <property type="protein sequence ID" value="KAF2860656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2860656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="438" mass="50142" checksum="A43DB76BB97F9241" modified="2020-06-17" version="1">MATCIARITKELAHLKRGDDLSLLVAFCDDDVSNVRCLILGPPETPYAFGFFEFEIEFPETYPIAPPSVRALTTNRGRTRFNPNIYAEGRVCLSILGTWRGRPGEEWSSAQGLESVMISIQSLMSANPYENEPGYESAARNSPEAMAYAAKIRHETLRIAVLMRLEKVLKIPSPDNEVRVVEIDAAEEPELAAFHWDPFVDALKTRFLWYYDAYLEMVEHEKGTHPAGEQFAKATFEYGNNKMLGEYQYEQLLDRLHRVRDALDAEQLAWAEDGLKQVETETQLASQLGFQFKQLQHRWHETQYDSSRMELSLPDEKNPFVWSLTMFGKPMTDLDGGIISMTFRIPPNFPDTQPRVSLDIPFYHRAVSSRGNVFYKPEKPEDLASHLISIVAALEDENPTYEPRASINPEASRLYWGGEEKRKLYLRRLRRSARDSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZA0</accession>
    <name>A0A6A7BZA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_232063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR050158">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
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            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="305" mass="34301" checksum="F42BBF708CA6276A" modified="2020-06-17" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZS8</accession>
    <name>A0A6A7BZS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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            <end position="216"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <end position="21"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="123"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="259" mass="28090" checksum="30C293C868256461" modified="2020-06-17" version="1">MSYASAVKDHGPKQSHDDKLADPVPEIKYSKSSSGTVDTMSSDTVNIPSYAEQEKEAEELKRDVAKSADKASKDAKDFGQKASADAKRLESEAGKQADELSKDASKKASQLSKEVSDEVDKASKVAGQTLDKYAKEFSQKTEELSKEASNDYDKAKASAARSYESAKKELREDGKKVEQIGRDAEDWAEKNKGNPVVIGNAVVMGVVAAALGAGAYRMNQAGTLTWKVAGTWAGIVGVFAVSDYYLSQWLFRNKYPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZT4</accession>
    <name>A0A6A7BZT4_9PEZI</name>
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            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_193377</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
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            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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    </feature>
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    </feature>
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            <end position="26"/>
        </location>
    </feature>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="60379" checksum="33AF713085652CB8" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BZZ0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_79163</name>
    </gene>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2421327at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Clr2"/>
    </dbReference>
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        <property type="entry name" value="Clr2_N"/>
    </dbReference>
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        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="20134" checksum="34A903D72C476A2B" modified="2020-06-17" version="1">MVLFVPRANTKHAASMAPVRYLRTPLVSDGNESCRPAPVLKYTPNDLAWLAGMGQLCCRGKSVAKRRRHTYVLAGLPKGYAGFDAPGKGVHHYMFGHPSGLPFRSYVRFLPHLLWLYEGKPRPCRCELCCGGGKKRKAPGPAEGSARFAPRVGADSAAPSGSQDLPVEMEVDVVEEVETGHAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZZ8</accession>
    <name>A0A6A7BZZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_231901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZZ8"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="231" mass="26096" checksum="55C2F74CBCCF5A17" modified="2020-06-17" version="1">MSTTHAMSDTQVQTELRKMTAFIKQEALEKAREVRLKADEEFSIEKSKLVREETSRLETEYRKKLTKAGMSEQIKKSTIKNRMRLRVLAAKQEVVDGVFDRAAQAMRMGEGHQGGEETLRGLILEGVYALARGEERVYLRCREKDAGMVRGLLDGVRGEVREKLGREVLVDVKEGEWLSGEGMGGVIVLNGSGKIEVNNTLEERLRLLESDALPAVRVALFGENENRKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C004</accession>
    <name>A0A6A7C004_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_257652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C004"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="320" mass="35718" checksum="07348E1C26150195" modified="2020-06-17" version="1">MSKPGDYEAVRKDIAALLKQPEYDDGSAGPVLVRLAWHASGTYDVETDTGGSNGAGMRYEAEGGDPANAGLQHARVFLEPLKEKHSWITYSDLWTLAGVEAIKQMGGPEVKWWPGRTDFVDDSKLPPRGRLPDAAQGSDHLRHIFYRMGFNDQEIVALSGAHNLGRCHSDRSGFEGAWVNNPTRFSNTYFRLMLSRTWKEKTLKNGVRQFVHYDEDAETELMMLPTDLALTKDPSFRPWVETYAKDKDQFFEDFAKVFSKLLELGIKRDASGKVTNTDNVKGGYVSAPKKSALPGKPDAVDKSGEAEPLKEENAKFRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C044</accession>
    <name>A0A6A7C044_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_294800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C044"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="49341" checksum="370020521DD84488" modified="2020-06-17" version="1">MPSARGENWEKYQKKFVDEEEEEKKITPLSEADIQVLQSYNAAPYAHALKNLEKQIKEKQASVNEKIGVKESETGLAPPNLWDIANDRQRMSEEQPLQVARCTKIITDEKDSEKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVERNKYQIMLPLPPKIDPSVTMMQVEEKPDVTYGDVGGKKEEIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGQGGDNEVQRTMLELITQLDGFDSRGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDMEGRAHILRIHAKSMSVERDIRWELISRMCPNSTGAELRAVATEAGMFAIRARRKVATEKDFLSAVEKVIRAGIKFNSTAAYAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0C0</accession>
    <name>A0A6A7C0C0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_281862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0C0"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="174"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="460" mass="52464" checksum="31B3AF6FB666E1AE" modified="2020-06-17" version="1">MTQQSPNPDIALPLSRGPGRRTVPSLMVRKSHLHDPRIGSIFRKDDVRETVRERPAERMSETEANDESSVPGRSRNQSKTRSGAPNKDKREEVVQKRFWIDDSGEHFHYLRSARRQEKLGNMIRDFMGGRRRQDPEEQPLSLVASWMDQMKHEKQAKDRSQGPNASATLVQKYGKCQEVVGRGAFGIVRIAHKANPTDSGKPEQLYAVKEFRRRPQEDSKKYSKRLNSEFCISSSLRHPNVIHTLDLLEDAKGDFCEVMEYCAGGDLYSLVLASGKLEVAEADCYFSQLMRGVEYIHEMGVAHRDLKPENLLLTTHGSLKITDFGNGECFRMAWETEPHMTAGLCGSAPYIAPEEYTDTEFDPRAVDVWACGVIYMAMRTGRHLWRVAKQDEDEFYDNYIRGRKSEEGYGPIETLHRARCRNVIYSVLDPKASRRLTAHQILNSEWGKGIRVCEASLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0I4</accession>
    <name>A0A6A7C0I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_257960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0I4"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
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    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
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    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
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        <property type="entry name" value="Malate_DH_type1"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LDH C-terminal domain-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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        <source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2860509.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="342" mass="35887" checksum="83CBA225595EFBE5" modified="2020-06-17" version="1">MFARPITSFILGAAQRRTFSATAAHASKVAVLGAGGGIGQPLSLLLKLNPRVSDLALYDVKGAPGVAADLSHINTKSTVTGYEPTPDGIKACLKGAEIVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAESCPEANILVIANPVNSTVPITAEVFKSRGVYNPKRLFGVTTLDVVRASRFMSQIKNSDPADENITVVGGHSGATIVPLLSQSGHKLEGAERDAYTKRVQFGGDEVVQAKGGAGSATLSMAMAGARMAESVLKAAQGQKGVIEPTFVDSPLYKDQGVDFFSSRVELGPEGVEKIHPVGPVNEYEQGLLDQCVKDLKGNVEKGQKWAKANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0T8</accession>
    <name>A0A6A7C0T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_257613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="750"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="521"/>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1491" mass="162860" checksum="28B077592AB44055" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Y0</accession>
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        <recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
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        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        </source>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q2</accession>
    <name>A0A6A7C1Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
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    </protein>
    <gene>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="153" mass="17617" checksum="71A8CCAC7EFFE02F" modified="2020-06-17" version="1">MGSLDRLNDELDRLWMRYLAALSQYTEARDRMQQNLSMATKGLVSLARANYAGKCHHGKEFYDDRMRASTECSITEHGELNVSQVSSEKDPIKWFGILVPRDLRSTQASFRRIVLNDVTEAVNAAAEMRALEREIRRKRKEVRKADRTASDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1W8</accession>
    <name>A0A6A7C1W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1W8"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="234" mass="26942" checksum="0406D917E778702B" modified="2020-06-17" version="1">MDRGKRDSSEDVDDAIRASFKRAYEAKFRPLPKEVRETRPEIVEQPVEDDVDDGEEWEGFSEDDQVEVVLHDAPRQYEAVDRRDTKEAKPSSTMASVETDDEERANLRNDLELQRLLKEAHLLDPLTFGNGAVGDRPGKIRLKAVDLRLQELGARSEQEKMPMQHRKGIIAKKDQREIKRRKEAKENGVILERLQKTKTKQRKRERGIGVPSVGKFRGGTLKLSSNDIRSIHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1X4</accession>
    <name>A0A6A7C1X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1X4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025386967" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="79" mass="8280" checksum="E3B2AA9FF5D3F374" modified="2020-06-17" version="1">MLTSVLTLALTISSAMAASVQVNNRCNFDVWTNLATGSPDVTQAELSKGKSTTVAITGLGHSVGITKAQGDYWSVNLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Y0</accession>
    <name>A0A6A7C1Y0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_263714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Y0"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="424"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="539" mass="60160" checksum="E4DD86B658245B76" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C280</accession>
    <name>A0A6A7C280_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_276126</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C280"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2861473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="616" mass="69274" checksum="1CA119DBAAC9C554" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2P3</accession>
    <name>A0A6A7C2P3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_29474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2P3"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="92" mass="10086" checksum="274450FE941A3CE1" modified="2020-06-17" version="1">MAFVPLNPRPMLQGLINEPIIVRLKWGETEYTGKLVSVDSYMNLQMSGTEEWINGKKNGTLGQVLIRCNNVLWISGGTKEDNDAGGDTAMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q3</accession>
    <name>A0A6A7C2Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q3"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="34"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="271"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2861754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="585" mass="64945" checksum="EF0C2DD0A3D04AA5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C313</accession>
    <name>A0A6A7C313_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">K470DRAFT_214187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C313"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="135"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="470" mass="50977" checksum="66F460E392E304BF" modified="2020-06-17" version="1">MALPGLDLPGLGLELGSVPPPGGEAASSATRTENLPPQSEWRFEAAGASVYNIKLTNGHAELFGSELALNVLYNLAGHNGSIFAWQGCTMEIAGEAESEYCAQETDYALEWLNTHGLLEELREQPGDGPRVLVVGPNNTGKSSLVQCLAAWGVRMKHQPSVINLDPREGLLCPPSGLTLATIATPPDPEHGFGISPIACPTLVPVQTPLVYSFPFQSIASNTEFYKSLLTRMALSMTSKMEENRKVKHGGFIIDTPGELNDPKGNYQVISHIVSEFSINAILSIGSERLYNDLNRKFGAATTVLKLSRPGGVVDRDAAHMKLLRRKQTIEYFFGSKRDDQVLSPHTHAMTFGEITIYRAKSQTQQSRGYTTNNDFDDYEPQSPASAAGLEVIEPSVGLTGSLIAVKLCPAASGEVSVRDSAVMGFLYVDDVDMEKKLIKFLSPHPQRWGDRALLWGDGPEVVADLHTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C348</accession>
    <name>A0A6A7C348_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="125" mass="13820" checksum="365BD3BE19E41561" modified="2020-06-17" version="1">MARDSLHRDCRDGQEPFVHGNRSKGSILWLCAVAAALLWILHGQMLLCIEQVLLAGLRSTLSVSGFLWRCNEAVESADEGLVPPAARLDHFTKRQKAVLWKKTHSGVTNHTYNIASTVSSIPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Q0</accession>
    <name>A0A6A7C3Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_256529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3946739at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="363" mass="39722" checksum="039D44FE286175FC" modified="2020-06-17" version="1">MSHRKRNSLFSKPLRSSLFRREDVAAEVASMPSSPSPSPSLSVVRKDSISLPFNFEHISHTERFNLPLLGSVRGRVLTEAFFAASMRPRPRKPLAGMRVDDVPEKLSAMGVARGASRSHPESAATATYPPVSLPVWLDSRSDLPLQPPPKADKDKSCSSSLLASTIIYTSPLKSPAMSDSWQSDWPIDWEHDVDYCYAQEAESTCDFDWSRPEKQPSRTPSVSSQNHAPLGHAGVLATRGAPGPTPYDISSASLSIPVASKPVFTPPNYGATSFATSAQREIEAPAAAAITATDGVDASPETSSSSRRISKSSLRNMLSRSPEASRDSYQERPRRSSTAAPRFLRSKRRQQQQQQARTEPAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C409</accession>
    <name>A0A6A7C409_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_8349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C409"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="288" mass="30860" checksum="E26F7C7F62A52013" modified="2020-06-17" version="1">MEDVSPGAWLRQRMSSRRMRFGLGRESLDQACGASLLQISDGFHSEVTHTLLTVTIHQSRSDPFPLPTHSKTMPPKKKESKKRVNTTSNEASRPGKRVQVDRPAADEQSDLRVAKTTAWPSSTIGRRVTRLRPFARSPTPQGSSHSPVAMPRSPSPLETIPPPQALARSALSSPAPSPPEPSQAASSMLPPRRVAPRAPRPQASLRAGGAAADAAPLLTASTQPSAAAVEEPPAGLASLLAEQNAEIIRHLQEIRGQGTPAVAKELQAASWSRSAWSSLMKSSPYKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C416</accession>
    <name>A0A6A7C416_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_213537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C416"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="315"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="753" mass="86751" checksum="D736AC99C0CC5BF0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C514</accession>
    <name>A0A6A7C514_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_228777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C514"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="478" mass="52059" checksum="3F1B5E73E52ADFEE" modified="2020-06-17" version="1">MSSRPRILPTKEEINSTSSLIKPTLPGVGIGLKEAQTHLSSLLPGLNRSSSSKHFYGFVTGGATPSARYADHLVTEHDQNVQVHLPHDTIATKIEVKALEMVCELLGLTPKEWRHKTFTTGAMGSNLLGLAVGREYVLGEGVLRGDRGQSGQGGKVEQRGSIAESGLAGTRRVQVLTTTPHSSIYKAASLTGIGRGNVHDIGVMELGVLEGWLKRDVGSIIVISTSEVNTGRFATKGGMLREIRELADRYGAWIHIDAAFGAFARVLPPTPEFEAVRSGASDLDLADSITGDAHKILNVPYDCGFFLSKRVDIAEEVCCNPNATYLSGGGDVPSPLNIGIENSRRFRAFPVYATLLEFGREGYANLVGNMVRLARGLVRELRKDGWETLPIKEDGVDEEEYVRETFMIVCFRFRDEGEDSRLGRFVEIVNGLSRVFVGRTVWGGRPAVRIAVANWQVDPEKDVGVVMEALREGLEVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C563</accession>
    <name>A0A6A7C563_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_213483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C563"/>
    <dbReference type="OrthoDB" id="5389734at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="229" mass="26110" checksum="BDA2938A8D253803" modified="2020-06-17" version="1" fragment="single">MKSEASEVSVTAEVRRKRLLDAERYDEGWVARWSQGPDAKHHPLLKLMSQIIFGLHLLQQEQAKSTKEVLRILQTHVIDMDNFMERTSDDLDLAIADIKQRTRHLRQPMRHMEVFAAMLADENFRSQLQNGHKKIEHIIARTGAALSASVIDIQEGLRANRELGKYLDSVESVWPGGYRKSTVAYEEMRGNEQGWSDYLFELLTKGQHLSDALLQLSAILGEMSKIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5R2</accession>
    <name>A0A6A7C5R2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein cwf19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_192516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="317"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="455"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63429" checksum="A2DF73F932D18369" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5X5</accession>
    <name>A0A6A7C5X5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor 1-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_255694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5X5"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
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    </dbReference>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <location>
            <begin position="139"/>
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        </location>
    </feature>
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        <source>
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            <dbReference type="EMBL" id="KAF2863002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="58311" checksum="D2A257B0BF30407A" modified="2020-06-17" version="1">MEGSDQIAAIVGTKRKRDGDALSESDRSPKRFATSLSIRSFDISGPDDPVAHWVLASNWPSSMGEPSNPRKRTAESITTVPINEYKKVIVQLPTNVQNLMKRENLEKYSKYGNGLYLPVPDTGLDSAEAWDERNEKFGRLNESYLVQKLTKLFLPHPADILTDEGPGMTNIEDYPDVDWEWRLPDITLDLKPKVFTVTELRRLENYNHLRPAMFAEGLSFPFFVCEVKALNGKWDEGLRQELGAAATYVDAIVQLCEAVKPDEVNQLQGQILGFGTLHNHEKIEIYGHFNLKDDNKEEINYYCHAFFDIKVSENFEVNPDYGVPGGRHPDRRMSSKSAAIIQELYTDFCVLHKKRILDYVNILSDATDLQVGITQEHLEATSSKRQRTAANATSTAQANNKVIATKDEVIEKLEQQVQQVRVDKDAEIERNNQANAKVIASKVAEIEELRQQLQKKNQTLERVQQQADNQHQLLSQQLLFFQCQVESLQEEVRELRKIPYGSGWIQYQMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Y6"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="353" mass="39047" checksum="BE0679075372DB21" modified="2020-06-17" version="1">MPPKPNIRTAAAPPPSGFTHLRTRRLISISGHDSPRFLQGILTNTIQPHSRAGVYSAFLTASGRVLHDVFVYPTLGTKWEQGGEAGYMIEVDGGYTDQFMRHLKKHKLRAKFGIRVLEEGELNVWNLWRDGVGRWTAHTKGMTGGLGLTDCRAPGMGQRVLLPGGTMPEEGGLQEAPDSAYMIRRYLRGVPEGQVEIPREESLPMNCNIDIMGGIDFKKGCYMGQELTIRTHHTGVVRKRILPVALYPDTPPDTLEYDPSGPTVDEQNADIRRQDKRKRSTGKLVASIGNVGLAMCRVEQMTDLAVSGEGSPFSPEDRFTVTLADGTEVGVKAFVPAWMRGRIREPKIKRTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Z7</accession>
    <name>A0A6A7C6Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_211407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6Z7"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="535" mass="59382" checksum="4050E7F8C9F9A735" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M7</accession>
    <name>A0A6A7C7M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_211378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M7"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
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        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="830" mass="92409" checksum="657896A81EFE7406" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7W6</accession>
    <name>A0A6A7C7W6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">DUF1760-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_255282</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863159.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="587" mass="65406" checksum="13CBACD8A7343669" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2863734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="61" mass="7179" checksum="A27E7C5DB953230C" modified="2020-06-17" version="1">MRPHRASVWYRRLQLSGRILPCDVPIKIWAFNDRPRGFAQARTSARLDQMRWNCDAPIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_196566</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4822at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="99" mass="11235" checksum="C90CDF9387114932" modified="2020-06-17" version="1" fragment="single">PQRSTTLPQATTDSAREARRSFFCDLCQKGYARINDFEAHEASYDHLHKKRIKELKQLSRDPNAASRAERERKANEEAGLKSINLSTTGASTKKKPVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U6</accession>
    <name>A0A6A7C8U6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_209514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U6"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="309" mass="34099" checksum="B6046751A15D9F24" modified="2020-06-17" version="1" fragment="single">MACQVASLAIYNPSLGPTDETFADQLVFWHSRVAREARSAAKRTGVENVDVARRDQNERLRQIGLAQGLVNFARTFSGGKPVDGVETGRSRIVLWPPEDGWWILASVDLAKVTAEVQTDEYSSRGLSPPALLVQQLRNAHRIFSLHHGSSWTTLYGSLGRERFCTALDRFWSRFARTWDVMLHDNPAAELLGGIKLGGGGELGFGVGEEDMGSAERAVLQDLVHRTEGLIDVVVSRFGEAEASGKESLPWLGSGRQPSSADGVVFCGVGAISRIDVGKMSLWIQQIFTDGELAYGIRQDPHRERRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8V4</accession>
    <name>A0A6A7C8V4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_268218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8V4"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025686227" evidence="8">
        <location>
            <begin position="20"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="860"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="952" mass="103197" checksum="63F2C7D8E07223B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C919</accession>
    <name>A0A6A7C919_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C919"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10308" checksum="C77E0F4C9806D612" modified="2020-06-17" version="1">MEKSLTSRSISQSILSLKISVCAGPFNHHKSCDALNPPLPSLPKNHTKPLPSTHPTLKTHTHRTKLSSPSSIERMKARTTHHMNPRTRILSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C968</accession>
    <name>A0A6A7C968_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_268039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <strain evidence="2">CBS 480.64</strain>
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    </evidence>
    <sequence length="331" mass="35686" checksum="A3B85251B3C90F37" modified="2020-06-17" version="1">MVFLHILFAATVAFSSAMAVPTATAVTSSVLPSPTSEAHQQIMSNWSFAVGNFYAGSADSTASLQPICKDIGALGHGQWSRQGLSPELIQRPICNMTRSENVNPSIAIPWTIRSLSDMFTTQLLGAFDGQYKQSSLGYVCNNTQYQALDAYNIDSQRVVNATCHAAGLEMRPQLVEPLTTPNMTDASVYIEALSALYGITLASTARDMRELDGICHAMDGRMKALNAMHLNGSIVLNGTCGRYRPHSEQPMGGHSGGPLPEDGSPMLPHTAFDLVRVQMTRMFTIVLKGMNRSLEWNSWLCQNLNIDGLNNVGLIGDGVTEVVCQARGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9H0</accession>
    <name>A0A6A7C9H0_9PEZI</name>
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        <submittedName>
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        </lineage>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864206.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="626" mass="70856" checksum="6D4BF6F82CECF007" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9H1</accession>
    <name>A0A6A7C9H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863645.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A6A7C9X3</accession>
    <name>A0A6A7C9X3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Chaperone/heat shock protein Hsp12</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_209714</name>
    </gene>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9197" checksum="954FCE0A398A7E7C" modified="2020-06-17" version="1">MTDSTRKDLGDKIADKATPNESKSYTDQAKDSLTGAADKAQRDFVPDNQKSTGQSLQDKVSRTGSSEADKGEGLLDKAKDAMGMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA56</accession>
    <name>A0A6A7CA56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA56"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="34140" checksum="ADDF7FFCEEFA6A8B" modified="2020-06-17" version="1">MPFTVPSRRLNTLPRLTTPPHPTFITSITTASIHFIYHHRFTYHSTPYASPITLCLSTMHFHSVIHPSSLLPGIGPMANVDRPFISITMTRFCGVHVRLPVRAKARRFKRWVFSRPEPICLGAFEDGVFAAGRVDGVNVTITKPFNLIPVDHLFKGHYDPKIGPRLEVDTDTSEPLSEVIARTLDGSAAEDSDEHNIIMDGTWNLDTEGTYEHSLTSTRSIMPYGSLRIPTIPTETYDPYDEHSTKPTRPYDSLQPTEACTSLKRPGRPEKTHARRQAPKKSTRYHLLAGTGTYKDLKSPTTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAB7</accession>
    <name>A0A6A7CAB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_254034</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAB7"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2864380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="31466" checksum="E8D366F6A1C989FE" modified="2020-06-17" version="1">MGTYVPLGNKMIDTRNTKHSTAIMSILNTTPDSFSDGGLNPVTDKAALESLVAKQIDDGATIIDIGGQSSRPHAPEITAEEEISRILPAIEAVRSLPAKDEIAISVDTYRASVAQAAIDAGAHIINDISAGLLDEDMLPTIAKLGCTYIMMHMRGNPHTMQNHTSYQGGLVSTVASELRSRVDAAHAAGIRRWRIVLDPGVGFAKTQKQNLELLRCLSQLRLAPGLHGFPWLVGTSRKGFIGKITGVKEARDRIWGTAATVTAAVQGGADIVRVHDVKEMAHVVRMADAIYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG7</accession>
    <name>A0A6A7CAG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_239056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
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        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="915"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113078" checksum="51C5121AFD663934" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CBE6_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">K470DRAFT_280114</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the oligoribonuclease family.</text>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857103.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BP54_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2857170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP54"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="60" mass="6602" checksum="225B9FD9ABC9ACC2" modified="2020-06-17" version="1">MALCIMIHQTYRHAATYGLWTANSSAWKVRVYQRSVLEVVIGILGLPNAVLLTVDGMDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPA2</accession>
    <name>A0A6A7BPA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_301497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
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        <property type="protein sequence ID" value="KAF2857206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPA2"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="449"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114200" checksum="DE453989793DA56E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPJ0</accession>
    <name>A0A6A7BPJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2857243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="366" mass="42039" checksum="0DDBC9C3DD659979" modified="2020-06-17" version="1">MPDRWLTAPPMCNVLTSASMDDSVEIETDLLVLDYLVHHAILACLQSRNTPEVHTPSALGPALSLASQAIGVFKSRHPRYKLHDEIQFRLALLQFVTLFTQRYTRNPSTPTRKEVQRLREKHAAKLIEWRKLADLPLNPRGKASEPLESHQLVNNRVQALRDLGCPQDLFYGTKSCLSYLDLLPLFLQTNFLRWQMMGAEENQITETWIDLVGEYLIQACLEQAFVFGTDSFEKVVDMAFSLGCPTRRLADSCPSQMFWDAHNMHENQKWRDAKQHYRQMLNSQIDSPYLLPYLNRIAKDHSHSSFEAEILNYLHSMATSIGSPVLTQLEERHLLYLGMTQDETQDFMANSGHPVSSFFRDPVGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BPT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006048">
        <property type="protein sequence ID" value="KAF2857350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPT7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17081" checksum="F46229A99D841DA4" modified="2020-06-17" version="1">MTQAVRANCGLECIAAMSLALADKRLFAQATFAHSVVSTSALSLIFPRSVRLNSSHFLRSSLNCLESGIEVTLLRKCLLGHEIASVRTPLSASAAFFNEFSFSLVSRLSARRSWYWWLRLLSQTILWTTRWLKTPSFPSVNLAIDRRQGEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQW9</accession>
    <name>A0A6A7BQW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_260643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQW9"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="108"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="63866" checksum="36CC2B98054C602D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR56</accession>
    <name>A0A6A7BR56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_273083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006031">
        <property type="protein sequence ID" value="KAF2857694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR56"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="609"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="819" mass="91667" checksum="290B09E32018C3DD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRE9</accession>
    <name>A0A6A7BRE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_283594</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
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            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="742" mass="82566" checksum="17B0D4212E7A72D7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRJ8</accession>
    <name>A0A6A7BRJ8_9PEZI</name>
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        <submittedName>
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    </protein>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="145"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BRM4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="15 16">
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRM4"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025544008" description="Coatomer subunit zeta" evidence="13">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2857936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21242" checksum="59D7A207AF72F33A" modified="2020-06-17" version="1">MPSNMSLFAVQAVLVLASDSSRILVRYYTSPHGGTQNPYPTLVEQKAFERGLVEKTSNKLASDVILYDNRVVVFKNEGDVMLCVVGNLDENEVLLYNVVLALRDSLSILLKDVIDKRTLIENYDLACLCIDEMVDDGIILETDAMVIASRVTKPPTQDVASMQGIDLSEEGLLKIYQFGKQKLGERLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSI3</accession>
    <name>A0A6A7BSI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial outer membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_221708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSI3"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33213" checksum="A8599B4D317DB02C" modified="2020-06-17" version="1">MTQPLETRQSTGIWSTPAPLKRLFDQLPLATYPANSLPTRAPRDRGQSVLHVFTTDDDARDGRPSFNPACLKWQTYLKFAQVEFRTVASSNHASPSGSLPFLLPSAGSEWQDAVVAGNKMHKWTGLDRERGSSHATHSSLIDNWLRKAWLFQLYLKPGNAAVCHRLYVAPCSSNPLVQLAIAHNLRNAAEAELINSCASHTLAEEELMQDADEAFNSLETLLGQQKYFSGTDTPDLMDASVFAYTHLLRSNAMQWQDNILGDMLTRYPGLVRHQERVMSEYFQCQRGPTPITWSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSU2</accession>
    <name>A0A6A7BSU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">K470DRAFT_272440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSU2"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="992"/>
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        </location>
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        <location>
            <begin position="16"/>
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        </location>
    </feature>
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        <location>
            <begin position="245"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="364"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1027"/>
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        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1047"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1068" mass="119609" checksum="B87CAB5FF732AC89" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTH4</accession>
    <name>A0A6A7BTH4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_197683</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
            <position position="1"/>
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    </feature>
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        <location>
            <position position="88"/>
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        <source>
            <dbReference type="EMBL" id="KAF2858510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9849" checksum="25157A2E87FFF7A3" modified="2020-06-17" version="1" fragment="single">RLGHVGTMILSRTKQVAVGLEGLDLSELAHCEPCHLGKAQRVVSRKPQPKPKAPLDKIHVDTVGPVEHDTLQQHRWIFILTDANGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK4</accession>
    <name>A0A6A7BTK4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_135601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="493" mass="53738" checksum="3C983FE95193EC91" modified="2020-06-17" version="1">MAFPLSALLNPEPEPEPEPGLMGYVATPVQQRGGAETSLPSFAWGSNQHAPAQTPDVVMTGTETEEIHGGAEATFPQTTTNIPPPIMEANAQPNSGIPSASQSAESQQKATVNKPEKITAKAAVRAPADPPIYRPMIVTVPTSEPAAQQSVPSPTSTMLAKAKRKQSGAARKKAKNAAAEAAATSAAPSAGPSVPASAAASTRSGASSPAPSADSTAATPSGKQEKYCICHRPDTGSFMIGCDGSCDDWFHGSCVGIAERDRHLIDRFICPNCEGQTTWKRMCRLQSCRQATREGSKYCSDKCGYTFMQEMIFKHGTNPTPIPGGRLTPQELKALVDSVDNVDDWRALGKRLKKTNENTQPIHEDPEIKKKKDAARAKHALLKDRLVFLNLAREDAQKQAEEKGLRAKDYCGYDSRLQWGDDQFAKWREGEAGKKMDLHADRDEDTVCDKKKCGRHNDWPKLFTDQFRYEMTLNGDQMRALEKQEREATLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTX4</accession>
    <name>A0A6A7BTX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_251307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTX4"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="103"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="54779" checksum="8F2BA23F33EAB98D" modified="2020-06-17" version="1">MSHTVARRALHCSRRLPVASPFARRIARGSGAAVRSYASESAPRKASVAETVRQDQKAFFDETGVGPRHVELSGLGVPGDTALSPAAGILKKATIMDEGTRPIYLDMQATTPTDPRVVDAMLPFMTGLYGNPHSRTHAYGWETDTAVEQARTHIASLIGANPKEIIFTSGATESNNMSIKGVARFAKRSGKNPHVITCQTEHKCVLDSCRHLQDEGINVTYLPVQSNGLINLEDLEKAMRPETCLVSIMTVNNEIGVVQPVEEIGRLCRSRKIFFHTDAAQAVGKIPIDVNKMNVDLMSISAHKIYGPKGMGACYVRRRPRVRLDPIISGGGQERGLRSGTLAPSLVVGFGEAARVAQEEMQYDTKWVTYLSKKLSSGLLAMEHTTLNGDPTRHYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTTEAEIDYVLQAVRERVQFLRDLSPLWELVQEGVDLNTIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ1</accession>
    <name>A0A6A7BTZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_221275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTZ1"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    <sequence length="479" mass="53608" checksum="9D76968FC5B36F37" modified="2020-06-17" version="1">MIREGKFVGWLQPSQQAALQWARMNGVEFHHCLPGEAQGKGSALLATDDEFLPGNGTLLTVPHELILSYERVLEHAMVDRDFRDVLEAIGDFGSTPRGAILVFLLVQASISCPNLGGRSGIYSDLTEYVKSLPMELLPTFWTIEEQKLLVGTTLAPAIAAKLRSLRREYDLVCDAIADTRWYGNVSHTIDFEDWLHVDAMYRSRALDFPGIGHCMVPCIDLANHASGESTVAIYEKDGHGNAILLLRDGKELRAGEEITITYGDEKGACEMLFSYGFLEPERTSAQTLFLSLSFEHDDPDGNSKSQIANCAPGVKIIDADDDEIDWTGDWIWLMCVGFDDGLRFQVARTVVGSDELHAFFKDTKILNGAAQIRTLLSQSELWPVYRLRAVVILQKRIFDQLQVLSSSWDDVAAVQHGESAAVRESVYKQAMQLRKLEFELLEQAYSNLERDKLELAEDNVVKEFLSKTQATPDFEDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU42</accession>
    <name>A0A6A7BU42_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
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        <name evidence="5" type="ORF">K470DRAFT_259535</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114898" checksum="EC25541B90F8B869" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUB9</accession>
    <name>A0A6A7BUB9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
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    </protein>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858794.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120328" checksum="CA9813FA48E3E7B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUJ1</accession>
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        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_259360</name>
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    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2858864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="606"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="726" mass="82153" checksum="B94E40C54612AB9C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUL1</accession>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_259560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUL1"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="591" mass="65467" checksum="DE9186EFC3BC27B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUR4</accession>
    <name>A0A6A7BUR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_259338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="290"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50173"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858950.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="575" mass="63932" checksum="0D9F43EACEB4F57D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUW7</accession>
    <name>A0A6A7BUW7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_278157</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
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    <dbReference type="EMBL" id="MU006001">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1550"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2858872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1602" mass="178623" checksum="F0E81DD3F6B420CE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV61</accession>
    <name>A0A6A7BV61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_272509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV61"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="97" mass="11487" checksum="2B61625AF6C6906F" modified="2020-06-17" version="1">MELVKELIEAGKEMVGSDNSHSTSRAHMADARLPMAYRDSCAHLLIPLNKCRYDNYYLNWRCKDERHSYEKCQYEEFLERVRRMDEIRAAKGGQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVR7</accession>
    <name>A0A6A7BVR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_283013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVR7"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="32462" checksum="2460873B6F0D11D1" modified="2020-06-17" version="1">MAEDMATKAPESDAQAVSGIPGDTKPDQGATSMVEHCVTDRPTHMQDTSKLGDVEVYISKPADYPHVSSRLLLLLTGGTGVHSVNNQLQADKYASEGFVVVMPDQFGGDSAPSTNTTAMSSAEENSTLIEQVKLGVATVAKSFTIDMWLARQTPEKVLPRLQAVLKSAREEFADAVSQGDGVYAVGYCVGAKYVVLLGAEDEAEKKPAIKCGAIAHGLQISPAELSSVKVPLSVVAVEGDPMFPDDVREEGMKALEKSSVEHECCVYSGVPHGFAVVGEYEESQIVTKQKEAFEQMLSWLKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT0</accession>
    <name>A0A6A7BVT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_234252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVT0"/>
    <dbReference type="OrthoDB" id="3694819at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49114" checksum="224FABAF68BAE62B" modified="2020-06-17" version="1" fragment="single">MLPIQITTQVSEEAKRFLRAAATSESLGRFSDAFEWYLKALEIQESTLGPNNISMLTTVNQNPKMFQQSTQNFYIQKAERYYLHARDGFRMTRNWEGIAMCLEKLGELYSQMGKWPAALDAMKQALEHSREHLSWLDEKVLERATKVAIYANQTGDLLLAREMTRHVFEGYNTLHGPTASETLNVLLERGKVEHRLGSEANAEVYYEKALKGYKACNGYTALYGPTASTTLSATMKLGRVYHRMGSEANTEAQYEKALKGYMKVLGLVSLDTIKIASTLANLYQKFGHQYLDKIEYLYLRALEGSRRLSQSFRIVAIGTKLSELYLKRRQLLEARRMLRHTFWIAKKSLSWKDSRMLRVVHDLGIVYRCLGINLRAAMALDWAWKGYREALGLQAEETLLVALDSAKLCHAMGIMKKAEEWYSIAFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW61</accession>
    <name>A0A6A7BW61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="120" mass="13036" checksum="589A3751B4ED8393" modified="2020-06-17" version="1">MGRDGYNAPLPRRMGRDGHNAPLSRSMGRDGYNAPLSRRMGRDGYNAPLSKGRDGYQIPIHFAGRDGYNSPVNAIVMGRDGYNTPINSAARDGYNAPLSMVVLGRDGYNTPLSTGRDGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW93</accession>
    <name>A0A6A7BW93_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_219094</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24016">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="507"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859484.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="772" mass="85066" checksum="4F185CAA0C0B89DF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG3</accession>
    <name>A0A6A7BWG3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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            <begin position="102"/>
            <end position="115"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="495" mass="56374" checksum="B2CA86C0EC308CA1" modified="2020-06-17" version="1">MATISNAWSMEEERQMNAIRSLYERIETLHGNFPVRQWGDLNQYESWRRELSLRTFRRIIESGPVGMESFGSFIARLLFAFENCMCAVLGSAHSPSANADISSNRSPPANPASANLTSADSPSTFERLCQILRSVYHELASEMRLLEPTPSHTSHAHPSGIIAGPARLESLMESTTDEGNSTYSSNHAANQNSHATYPISTIGQRRCEATLVPMSNQIRLSYPSMPPLAEDSPTRLLNAMLNLGVQVFSSNLSPNPLLVTDVQPSMPALNPIDAGNSDVSLQSENINLLGTGVPRVITPYDWMHQPPDSDSAATEEFQPTEMVQNMPLLSSPRPPPQRRNRIARSRACGEFLEGERVNERERFMSNRRFELEMIINEERHAYISRQALRSTPRGYEQQLRQEEIEEEVRDWMEENGHWWRRLRPDEADHMRSLGFVVDFDDRLFMWEGNFALLGVRDQRDLRDISVCFLDMDSFDALRCSWIPSRPLEMWTVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWW9</accession>
    <name>A0A6A7BWW9_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">K470DRAFT_195955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00250">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
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    </dbReference>
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="74" mass="8549" checksum="8442F2E7A698820D" modified="2020-06-17" version="1" fragment="single">YAKLLYRCLMEAPGHALTLKELYEWMKVHSQKAKDPNNSGWKNSVRHNLSMNAAFERVPPSEVHGVKKGSLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWX7</accession>
    <name>A0A6A7BWX7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_234223</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWX7"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="67"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="583"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2859603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="782" mass="85210" checksum="B5CA944D86669E42" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXJ0</accession>
    <name>A0A6A7BXJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="339" mass="37585" checksum="9D323B33708B2124" modified="2020-06-17" version="1">MLPISEPSTDQHVRARGSKATGRGAADVADAVEGSAGASAMDPPISSPGSDSALPQTLPRALPQTPSFAHSPFLPESPSPYFPPSPTPHFHPDDEEEFTQTDLYLLRLERIYTTLSKQVSNPSQQRDAERLISQVEDELEARHSQTRLPAEVESSGLFDDEEGEGEGEGREGRESPSPPGVVDVEFPSSPPLPAFNGMEAERSSPSKVSVTNARSILQLLHEVQAQLKERLSDVVEQNEEYLFLLKEKEEELEEAWAEIEELRGEVELLKGRETVVAEEGKVETNAVEWQEKTSLVKDSKGEDESNKEEEVKDKIVKKKSAWEDLWDSLEQFAGMMDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXJ5</accession>
    <name>A0A6A7BXJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage/polyadenylation specificity factor A subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_249829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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            <begin position="306"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56089" checksum="8A6BE54D9084780B" modified="2020-06-17" version="1">MSTMSSMSCPDAEILDLGPQRFSRPDSQARLSSWRCNLIALSQVYNLFFLAAGSSIKVYIPQYPRHRLPPQPALSIAIPPTSTNLQGYINLREPHSINRILVAPLGVEEILVIARDDGDVNCIYTRHIHQSVQDHLPAQGVRPFFQVNVGMSAWGLAVHAKARLLAISSNRHEVLVFSFGLVDHDGRILRDDSTKVIAGWTNIPCVAFCNMPYDEEGRWLLFTDVSGVSSVVDLSMDPPQVVQNFGFVPGRITGFDRWNAGWIVEFLDPRSFIVGDENAPSNQTPPPAVWNQGDELERPFVTVNDDTGENGDEVEDDDESENENENIDNNENDIEDGDGNNSDNPSLPTRTRPVYLANQERILHPDLPCPILHTSVRHIHILPPNIKSEPVIGLEQPSNGTGTRQRFNMHAYIPHLGILIVASQTGSAAIIGLCKVDGSFMCRPLHTLDGTAKSSSPTTTLHGLTASPIPNARKRWRIIFFLSDWTVLRYEVSRDYGELSFIPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXJ6</accession>
    <name>A0A6A7BXJ6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_233667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXJ6"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="47199" checksum="695A655E4D84C3AB" modified="2020-06-17" version="1">MSKIGCGPSALSEFPLAKGYRNLNHGSFGTYPLSIQPILDKYRRDCEARPDLWIRWEYPKLLDRSREAIAAFVHAPVETCVLVPNATTGLNVVLRNLTYTKGDTVIYFPSIYGACEKTIMHLMETTPLSAHRLDSSLSVLDGDAICDSFRSAITTLRSRGQTPKVAVFDTISAIPGTRMPFERLTQICREASVLSCIDAAHSIGQIPLNLTQLDPDFFFTNCHKWLYTPRGCALLYVPVRNQHLIRTPFPTSHGFVPRVGQGINNPLPPTTKSEFVNNFEFVATLDNTPYLSIPAALEWRRRAVYKNLEGDEAIYTYLHTLAADSGRVVAEILGTEAMEQHPRSAFANVRLPLTSTASKAADVARGITDVVLREYDSFVLVYVYNGMLWVRLSAQMYLGIGDFEWVGKVLKGVCERVQRGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXL6</accession>
    <name>A0A6A7BXL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_277476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXL6"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025663180" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="32"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="549" mass="58329" checksum="A84D1E14DB1872D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXP5</accession>
    <name>A0A6A7BXP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_80399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16919" checksum="059550DB692ED666" modified="2020-06-17" version="1">MTVFSLLIINKAGGLIYQRTFSPGLQNLNSNDYLVLAGTFHGIHAISRTINPVPEPPLPNPVPPGVRRRPLTTGIESLSSSHFRLTCFQTATGVKFLLFTSPEQANTETIIHRCYEIYGDYVVKNPFYSLEMPIRVEKFDRALAQYLHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXV7</accession>
    <name>A0A6A7BXV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_258457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXV7"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="361" mass="40844" checksum="3DF384C395204C53" modified="2020-06-17" version="1">MPTELEELVEFLHHGNTQIRQIAAENLVGYSTQQPALFKRNQLEPVKDLKLLVKDYAPIAKNAITILINTSEDGEVLENLATDDAFLESILRRVVDAKEPNADDICMLLANLSKSEAMIKLLSLKREVPKSLSSSPLAIDQLLDCFVKGADGKYNKNAGYNYLSYLFADLAKHDEGQKHFLKSGDDDVVPLTKLIVFTEHKSTIRRRGVANTIKNVSFNISSHAEFLSPRGVNLLPYILLPLMGNEDYSEEDTEGMLDEVQLLDPDKQRESEPDIICTHLETLLILCTTREGRDKLRNVKVYPILRELHLQVKDDDVRDLCDRLVQMLMRGEMSSSNNQAQVKPQVQEVEEDEDDQIVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXX7</accession>
    <name>A0A6A7BXX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_264729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXX7"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="28433" checksum="A2CF0B087B0A6981" modified="2020-06-17" version="1">MTQQQPTMTKAWARTYSMADQLDSVAAKFTDATSVYTTRRGQYLDQWHQRQNSCGGGQYGRAKLQSGKKYRLRLINSAVDNFYYVSLDKHPLQPIASDSNPIEPIVVETLLVAIGQRYDVIIDATQTPGNYWFHAAVATPYGSRNGNWEGRSIFTYEGANFTEPTSTRYVPPQPCDDLPNLTPHWKQSVPREGFEASPGEMDIDIKEMSPTCNGDMVAAWTLGDVPLNIEWNNPTLQYVLNGSFTFPPRYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXX9</accession>
    <name>A0A6A7BXX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_300208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXX9"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BY78"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="471" mass="50817" checksum="FC43806B278182E9" modified="2020-06-17" version="1">MAAVALESDSPQAEQIQQAAQARLIEIGWVSDESDTTLSEYVTMMLVNGKEAREVQTELGGELLGVGEDDETVASFTAWIFEQARALVDGAKPTVGDTLDERMTDAAITEEPCVPPLGASDLNMLTRSSPKGPRAMRNGDGSGGRGRAGRMIGHTKDHTDRSEDPLRRIQSTASATGRIDTHRPPRGPRSMMRGRGGPNGPNGHGGHGGHGMQMMPNQMLDPASQMAFMQMMEMQASMVANALQQGGRGRGRGRGGRGSFGGRGGHGQQNGDAQSNAGPDLDKPLTDTAAAKPPFDIMCKFNLFCQNPDCPYAHQSPANRRPNATLDMADTCTYGIACQNNKCLARHPSPAQRQSYKRSEVQCKFFPNCSAGPACPFKHPDVRPCRYGADCKVEGCPFAHSQIVCRYHPCKRADCPYKHAENQKGTFEDKVWIAGGEPRDEPSGTANRFQELKNTEGNAEELVLPGSDEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYI5</accession>
    <name>A0A6A7BYI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_257859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYI5"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="32149" checksum="1DB4583E1F734EF7" modified="2020-06-17" version="1">MANRQGYDVVVDVDAEGDLGHTDLNDDLEFHNSSFGAPDSSSSQKPIQSDQAGFFSSASGNSRGQSAGSKRYLWSLSFYQQFFDVDTSQILYRCRSTLYPRQNFLDTLEGQPDLYGPFWIATTVIVILFLTGTISSFLASESKKHFAYDFRLLSGAAGLIYGYTCFIPVGLWGVLKWFGCESANLVECWSLFGYANLIWIPVSLVSWSPLSALNYAFVGVGFAVSALFLFRNLYPVVSATDKKTAQIILVIVLLLHAGLAIAIKILFFAHGSPVADKGGNLPDPMGDSDRTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYL9</accession>
    <name>A0A6A7BYL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_271363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYL9"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37099" checksum="9E66D564E3823BA9" modified="2020-06-17" version="1">MTLIYAEYLPNIKTLNIQIILPSLTNPSTKLSLSPDNTYLTLQHNSETTTLNLPAHPTSQPLPIPSKPVTELNYRLPALCPDTPSPTIPWTAQDLTQTTSILCSSCKATLLPCGAVKTWKNLPSEHWADMMDLWHCHKPLGGAATIAERRLVIEKGVGLVDLMDIVIDQTDCMDVKINATHALCGTCGEVIGMKRVEDGVWLRKPFLSVSLSPARKGDCFPLENWLAEFILQEVEWQGVRKFVVEGSGEALRIWAFAMENLVSSSMWDKPGRVVKVLWCEIEKDGRQEGLLMGEIGLRETPQLRDLLKESAVALPESMRVFQGWRVGLLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYN6</accession>
    <name>A0A6A7BYN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_271380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYN6"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="15927" checksum="D09118EF7E7348FE" modified="2020-06-17" version="1">MGEVSVTASNWRLVETGRVALFATGPYEGRLAAIVQIIDHKRVLVEGPSSDKSKVVPRHAAPLSSLGLTSIVITGLPLAIGSGGLKKCWGDQKVEEKYGNSVTAKRAAALKRRKQLNDFERFKVAVLKKQARFEVRKAMASRKGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYT6</accession>
    <name>A0A6A7BYT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_257982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYT6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15347" checksum="825F4AA7C5B83456" modified="2020-06-17" version="1">MTTGRIIKWYKQTYFTLLVSEQRVTLDRGNFARFHHDQIGKVERIFTHRDSGGDARIFLRVIETVSHPCGQLEPITGRPLRQLVTMEARIIGLPAAHSKRLYIIPIAMDDASGAMKEQADSSDLLHVDWNNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYX8</accession>
    <name>A0A6A7BYX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin Cpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_282402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYX8"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="11250" checksum="C850384E89A961DA" modified="2020-06-17" version="1">MQSLAIKSIKSLAPLLDRVLVQRVKAEAKTAGGIFLPDSAVKELNEAKVLAVGPGLLDKEGKRIPMGVAAGDKVLIPQYGGSPIKVGEEEYSIFRDHDILAKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY0</accession>
    <name>A0A6A7BYY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_258444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY0"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="504" mass="56068" checksum="011C8C5FC01290E8" modified="2020-06-17" version="1">MHNHEESAVTIGELADGKGQLQDQEVNDACTNGDVHAPSNGHANGQAHVHENGSKALTNGGFHSVLSRFDNSQVHDLVCVGFGPASLAIAVALHDALIEGSLVTSKPKVRFLERQPQFQWHAGMLIPGAKMQISFIKDMATLRNPRSHFTFLNYLHEKDRLVSFTNLGTFLPLRREYEDYMRWCAEPFGEVVDYDRQVQSVTAGETDAESGVIKNFRVISSDSWGKTYTLYASHIVIAAGGKPNIPKGIPTNHPRIIHSSQYVTNIDSLFAPENHPKTIAVVGAGQSAAEVFQDLPHRFPDSKSVLIIRGASLRPSDDSPFVNEIFNPEHVDEIFSQDADLRNEELVRDRGTNYSVVRLELLEEIYNTLYSFRIQYPDEKNWPQRIFPRREVVGCCDIDGAVELTLRDRSGRKADERLKADLVVVASGYVRDSHVDLLADLSHVMPKGGWKVKRDYSVDFVPDTVDEKSNIWLQGCNEQTHGLSDTLLSILAVRAGEVVGSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ28</accession>
    <name>A0A6A7BZ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ28"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="41677" checksum="FDC92C4F898D525F" modified="2020-06-17" version="1">MQEDHKLTFEPTAQPEFSPIIKSHILNCSYNAWYPIYRHLAPKSEIIPLTKPFIEYLKCDGIVVPPDKPSSQDDDSDNSFTSTSSFASWSEIHTQITRSITKLGGHIIPKLNWSSPKDATWMNANTLECTLPSQIYLLLKASDFVMHDFEYPFDGCVASSEGVGGSGKGGKGGADEKKGEGSFDDKERVEDSDDAGVEYVLVLRKYMDINPASEFRCFAFQRKVVGISQRDVNYYPFLHPMRETITTNILTFFEKHLRTFSDENFVFDVYLPESGKVWLVDINPFAPRTDALLFEWGEVLGMDRDAPPEVRFVEKNDPRGFNFGEMRFSASKLPIEVVDAGRTGEGIVEFARGWRDIIGGKGGEETDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ65</accession>
    <name>A0A6A7BZ65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_270492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ65"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <location>
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            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="22804" checksum="6F0C155E19E2C18E" modified="2020-06-17" version="1" fragment="single">MDLLKTVEKSGSSRGGVNFSWEDVKKSEFRENYLGHSIMAPVGRWQKGKDLNWYAKADDAGLSPEEKRQKEEQRRREELRKVKEAEEDAMAAALGLPPPDRSEKLPMAMSIGSSAGPARPEDGAPSTSGDGPSKRRRASRSRSANRRRREESFSPQRKRSRRHDMRSHGHSDYHTRSRSISRDRRRKLEGRRGERRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1D8</accession>
    <name>A0A6A7C1D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_195196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1D8"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="14606" checksum="EC72B5CE3F224EEA" modified="2020-06-17" version="1" fragment="single">MARRSSARLRNCNSSTPKRVSHLVNDEAPKTVPAKLGSLREEDEPVPGAFPDSPSPVSTPSRAAALKAAKERPDVTPQSGTIRPSDEEMHPQLHHTSTAKPLEEARYLGFARLAPHTEPPKGSKMHVFQTTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1R7</accession>
    <name>A0A6A7C1R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_257639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1R7"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="147"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="418"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="572" mass="63360" checksum="69739451006FC762" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C213</accession>
    <name>A0A6A7C213_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_269946</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C213"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
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        <location>
            <begin position="8"/>
            <end position="281"/>
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        <location>
            <begin position="282"/>
            <end position="592"/>
        </location>
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        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="927" mass="102133" checksum="53A0FBCFAC42D2AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C273</accession>
    <name>A0A6A7C273_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_299281</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="335"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="433" mass="47748" checksum="E1E863C2017FD051" modified="2020-06-17" version="1">MVDTDKFGPRSMKRRNVKGLALAAPPKPTAPSNEDAQLPGSLANTNSQRTDTLEIGVEFRPDWRSEDLEVVRDLGAGNGGSVSLVRHTGLNITMARKIIHVEAKKEVRKRIVRELQIMHECNSPYIVTFYGAFMNESGDVTMCMEYMDCGSLDSISKTFGPIRVDVLGKIAEAILGGLKYLYFTHRIMHRDIKPSNMLVNSKGQIKLCDFGVSSELENSVADTFVGTGTYMAPERIQGSPYTVKSDVWSVGLALMELAIGKFPFSMPSEEDDEDEPSGPQGILDLLQQIVLEPSPKLPKSDAFPQILEDFVEKCLMKDPADRPTPQELYDSDPFLQAAKRTPVDLEQWAKSMMVERRKVKEGETQREGGGKKEKDREKDVSTTPDRKENVEASPPANAEPRPLASKEGGKGAIPPGPGTGQMQLPIRTRGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C277</accession>
    <name>A0A6A7C277_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C277"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="17232" checksum="D35124E87A5FA4D5" modified="2020-06-17" version="1">MVSRRAGPETRKVLQELSQIALNTAARLTLAEYGCSNLEKSLALERRKRKRKSRLVEQVRDAKEREEQEKAQRAREREEAKASKAAETLRKRQERQAAKDARMAAKARKKAAVAARKAAAQRKDDDDDDDDYVEEWQPRRSARQTIGKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C289</accession>
    <name>A0A6A7C289_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <name evidence="2" type="ORF">K470DRAFT_263199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3C4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="485" mass="54737" checksum="1B732F6516F38466" modified="2020-06-17" version="1">MTLPTSESFCWLDSDYSKYFFLPRSQTLPSQPSFFFQSPSLTCIDLYTRTAKVCEHLREHRPSPVFDLRLLFGTGPPRDYCPSAKILQGATVYTCPSFQRAIYLVLGAVFLRRAGVTSNIKSRHGFISTKMHSSTRAKNASRQVTRVKNRPPQASPRAKRHRGEKIKSAIQKSINSRNSYNKSNRSRDMEGVKLPSCSLEPSACAQQMWEWLENPQAAADPCFMKAQYEYVDPHWLDSEAPVVTAPSSGLLYDAQDQKKAQFQRAEFLTMQGSIDPQVLARQREYAGKDQKLHYAKNMASKGIPEIYITPPTPKIGPKRDPYFLSTINLGTASFPYNLKKNEHLKSTAYDSVSPDKQFQLKYSCVRCNLQGSLPPGVTADSTQNLYCDKCGGYVDCQVITYKPLRRKIPIHRLRGSERERPAKRCKLYQFTDHLTVPGAEGSEKLRKLSDGKGEMVWGGDYVPADPERRLDGMLVADLMGRTKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3G5</accession>
    <name>A0A6A7C3G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_256285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3G5"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025663183" description="alpha-glucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="12">
        <location>
            <begin position="171"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="11">
        <location>
            <begin position="336"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="13">
        <location>
            <begin position="767"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="993" mass="110210" checksum="2F6FB65A5CBE97B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3T9</accession>
    <name>A0A6A7C3T9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_256119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3T9"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="221" mass="24552" checksum="473A7F772B8D0F87" modified="2020-06-17" version="1">MFKQSVRRLAQRGTPLYSNLPYPFVTESTGGGWQTFDIFSRLLKERIVCLNGEVDERTSASVVAQLLFLEAENPSKPINMYINSPGGSVTAGLAIYDTMQYIRSPVATICMGEAASMGSLLLCGGAKGQRQCLPHSRIMVHQVSGGYHGQASDIAIHAKEILRVREQLNKIYQRHLTPKEGGKKSLDEIEKIMERDYFMGATEALDWGIVDKVLDRKQDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3U7</accession>
    <name>A0A6A7C3U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">K470DRAFT_298743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3U7"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="117"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="303" mass="33535" checksum="C5C1A8D82B208FD8" modified="2020-06-17" version="1">MSLKRKAGTKALDSAKKPKTNASITSFFSTNPAGSSSTTPKPASSQFNKEAWLETLTPEQRDLLSLELTTLGPTWLAALHTDLTTPSFLSLKTFLAKEVSQNRKIFPPQAEVYSWSRHTPLDNVKVVILGQDPYHNDNQAHGLCFSVRPPTPAPPSLQNIYIALKNDYPDFEKPPKMGGLLTPWADRGVLMLNACLTVRAHEANSHANKGWEQFTQRVIEIVAKKRTRGVVFMAWGNYAQKRCASVDAKRHLVLKAVHPSPLSASRGFFECGHFRKANEWLKERYGEEGPVDWGLGGVEGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Y2</accession>
    <name>A0A6A7C3Y2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_194943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Y2"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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    </dbReference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">HRDC domain-containing protein</fullName>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0071044">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <source>
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</entry>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2862079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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</entry>
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    <name>A0A6A7C5F1_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="318" mass="35623" checksum="1F4A4A1923F11E44" modified="2020-06-17" version="1">MDFQKEIAFLVNGVVATDIDAVQPPRPEPIVESSTNLANGHQDMSNCEEMPLDANKRRRFNADATLNEPVTDISTRLARFNRTLETPARMIPWTLHMKDSDKFDYYTKNVKITYPDNGSSVSMVIPGVVLHCDTFNHFGKTGAYIGIPKQLTDMLTNKFIAVRQHAVIDYPTVASDDRYWWAKQGFGAAEAEKEYVYVVDEDNGEIVEDAFPSFPELFNTVGVTCALKMRAKLSVAKKGAFTAEDELRMGISVSRANITDIVDVDKPLSGLIQHSIAGTKDKASALLQESKPQHLYTRHSLEKEISPLRFCVRDSMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5H3</accession>
    <name>A0A6A7C5H3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_243313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5H3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="91" mass="10232" checksum="F70557B4AA7FB563" modified="2020-06-17" version="1" fragment="single">HSHYHAATGILTYTHLHLSCPCFRLSLRPLRVAVHSHPRELNTYITYNDGTAQARVDLGQKITAKASSLVNRWDENPIADDTLCFPFGCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I5</accession>
    <name>A0A6A7C5I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I5"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="89" mass="10657" checksum="A00102458E353247" modified="2020-06-17" version="1">MSELWHADKWRWELHLQRPMETVEIRGIIKDIWLGTFSSWKRNYLGTLYFTGAKFRHLKMEVDRLSERFQPQGVAKNPSRRSFSSSKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I8</accession>
    <name>A0A6A7C5I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_166346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I8"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="345" mass="38776" checksum="D40C02BC3529E412" modified="2020-06-17" version="1">MASIQEVQVTALAVMRIIKHSTSAFPAPATGCILGMDVDSQLQVTNAFPFPAAHALAAPRTKLAQKYETEMINMLREVNVDAQSVGWYMSCSMGSFVTPAFIENLAFYQSREGDQSVALVFDVSRSSQGSLHLKAYRLSPQFLAAYQEKKFTSESLQKSGLRFQDIVIEYPVSVYNSHLLTCYLHQLPSPPPEDSVHLPASVAEILRGRISSSTLYPNFDNLELSIDPFLEKTSELISEAVDAHQTEQNNTQYYQRSRAREEAKIAAWQQKRKSENALRAQQKQPLLPEDEWTKLFKLPTEPSRFETMLIGRQVDQYARQIDGFGAVAETKLFSITGNLLPRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5N1</accession>
    <name>A0A6A7C5N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256238</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5N1"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02773">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
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            <begin position="125"/>
            <end position="245"/>
        </location>
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            <begin position="247"/>
            <end position="384"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="390" mass="42985" checksum="7530B526AD334368" modified="2020-06-17" version="1">MHANGVLKKGNTFLFTSESVGQGHPDKIADQVSDAVLDACLKQDPLAKVACETAAKTGMIMIFGEISTKARVDYQTVVREAIKDVGYDSSDKGFDYKTCNVLVAIEEQSPDIAQGLHYDEALERLGAGDQGIMFGYATDETPELLPLTIQLAHKLNRAMTDARKDGSLPWLRPDTKTQVTVEYEHDGGAVVPRRVDTVVVSAQHSPDITTEKLREEIMEKIIKKSIPAKYLDERTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVHAKLARRVLVQLSYAIGVAEPLSLFVETYGTSDRSSDELVDIVRKNFDMRPGVIVKELDLAKPIYRETAKNGHFTNQNFPWEQPKQLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5T3</accession>
    <name>A0A6A7C5T3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21452" checksum="DEC863200CFCC600" modified="2020-06-17" version="1">MNFEASLGVKIIASESLVGREAHISTQNTLHARKAPRDHPHITDRLDRDQRHGWPSIVNGYTKPSLKRQDRISIASLAFGLVALLRVTLCLRSYFIEDRGADRALTDGLHELSTRIEQFKRQGELKEAQKDTSPSSTMNASSTKTTRSSSCGCQKGNCLCGRRIRAKDLWCRVISHSAAHWRYRAVPITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5U5</accession>
    <name>A0A6A7C5U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_244215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5422613at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="142" mass="16122" checksum="CE38D1FF38CFF94F" modified="2020-06-17" version="1">MGKDPRVSVSHLMLQRSLESLPGGTKRKAQEEIKICTKCKDAFSQSENDKAACRFLSGDLEPEDVWLDHDEQCHGPINRSENRRDHIEAFIYACCDKRGGEEGCMKGPHRVIGMNDLWKGGVIHSDEDDDDDEDEDKDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5V7</accession>
    <name>A0A6A7C5V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_268769</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5V7"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <position position="136"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862820.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="46159" checksum="14E632CB689A923F" modified="2020-06-17" version="1">MTQPKSWLDIDPDSPFSINNIPFGIISTPDSPTPRPAIAIGNYALDLQAFTQHNGFSKLPDIKDLDKVFSTPTLNAFASLGRPTHKSVRNYLRNILLSNGPYPEILEQNPTLHPTLLIPLQNCTTHLPMSIKDYTDFYAGLHHAQTVGTLFRGPQNALQPNYKHLPVAYHGRASSIVVSGTPIKRPIGQILPQRATHPILSPSKKLDLELEIGCFLAHTTRLGERIPLPSTENHIFGFVLLNDWSARDIQAWEYIPLGPFNGKNFATTISPWVVLLDALEPFRTKGIANDVGVLSYLDEEGEEGFYDVRLGVRIGETEVCVTSARELIFSFGQMIAHHTVGGCPVSAGDLIGSGTISGVGVGEKGCLLERTENGKVEVELGNGERRLFLEDGDTVTLTGVCGERGGLVGFGECKGTIVKADDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C723</accession>
    <name>A0A6A7C723_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_142917</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <end position="50"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A6A7C759</accession>
    <name>A0A6A7C759_9PEZI</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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            <end position="149"/>
        </location>
    </feature>
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    </feature>
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            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C802</accession>
    <name>A0A6A7C802_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_205293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C802"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12824" checksum="70A4D173B73CF57A" modified="2020-06-17" version="1" fragment="single">IGATFQALGRWDDTVTALDSSLGLKVKVLRTDHPSILSTASLLAGLWDNHARLDSAVSLYRHVHDCREVKLGPYHSDTLVSLCDLGRNLMAVGRPEDAEEILSRAYSRLSFQLGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C840</accession>
    <name>A0A6A7C840_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_212172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C840"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="397" mass="44578" checksum="C7B5D88A5E188F67" modified="2020-06-17" version="1">MAKIKPSKQEREAKKSFEKNKNATKSLETESPEQLYAETIDLVQSQPGKALEKAQMLWNQVQNGSTLEKLPALGLLGEISETLGEIDNARAYFEKAVELDPEGKESNLMEGGAEKFLWLAQLCEQGGKASIGWFERGVRVLEREIAALGDGATTGLDRESLLVLRVDKQKKLADALCGMVEVYMTDLSWEEDAESRCENLITKAIAVEDEPSPGVLQTLASVRLSQQREDDARSALIRSIQSWKHLDPEDPGVPDFATRISLCRLLMEAEMERDAMHVITRLVDEDDESVEAWYLGGWCQYLIAEKLQSNGKTEEQSRRQAALKGSRHFLKKSLKLYSQLSYEDEQLFAHAKELVSKLDEILGPEAEHTDGSAEDEEWENWDGFSSSDDEDEEMVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B9</accession>
    <name>A0A6A7C8B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_292905</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8B9"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="92"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2863477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="444" mass="48092" checksum="19AA26D111A14609" modified="2020-06-17" version="1">MGLFSDIFTSMWNRILDNKGKITSTGGFLLGVLLTLAFKDLYPDLEHSFRKRLNYHQHIDSTLLSPARGVQLEDHENDSQPPDEVSPPSHGIEDLIGNTPLIKLPSLSSATGCEIFAKCEHLNGAGNSPKDRVALSMLVHAEESGLIAPNRGDTIYEGTVGSTGISLAAVCRSRGYKAYICMPNDQSLEKSDLLLKLGAAVERVKPASIVDQEQFVNLARRRAEEHTSDPEKPGRGFFADQFENPANYLAHQRTTGPEIFKQMGGRLDAFVAGAGTGGTISGCALALKPVLPGLRVVLADPQGSGLYNKVKYGVMFSNTEAEGTRRRHQVDSVVEGIGVNRLTKNFKVGMHLIDDAVKVTDQQAMMMARWLVEKEGLFVGASSAVNCVAAARIAREMGRGGKKARIVTVLCDSGTRHLSKFWMEVGDIGGEGDGLELDDILGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8H4</accession>
    <name>A0A6A7C8H4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8H4"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23200" checksum="0B4A4B967702F404" modified="2020-06-17" version="1">MGWWWSFSSDDKSSNSSVASLTDGQKERIFGVCPQPQPQPQGANPNPNPDEEWTALIKSFEAPSSTPEPSTQTPNPHPPEDKPQPHDRYLPDGSLNIHPDSLYPVAMSCRQAFDQVFYCQSLGGKFNDVYRFGSVQDCSDQWAAFWFCMRNRTIPAKDKQCMVRNFYKERDERRKREKGSSEDIWPLRTKALERAFDKDPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8H6</accession>
    <name>A0A6A7C8H6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_209991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8H6"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="294" mass="31877" checksum="54A63586C5D84C68" modified="2020-06-17" version="1">MAETHIFEANKLFSVKDFVCLVTGGGTGIGLMATQALAANGAKVYITGRRMNVLQNAAKAHSDGAIGQIIPIGPCDVTKKDDLEKLYQELSKKEKYLSLLICNAGMTGPRAKPDEEDASRMKQKLWENETLEGWQQTFDLNVTSVYFTTVALLPLLQASIEPTGPLPRFSPSVITISSMSGLMRHAQGHFAYNTSKGATVHLTKLMSAEFQKTGIRINSIAPGYFASEMTTKASDDSQKSELSAEKIKEKGYVPLMRGGKDEEMGMAVLFLTKNQYVNGQILTVDGGVLNVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C990</accession>
    <name>A0A6A7C990_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_280062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C990"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="68"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="392" mass="43870" checksum="7BA2F71F9BF408E0" modified="2020-06-17" version="1">MRSEDLSTWCIMFNWSSIGMCIVLVQKDLVVVKPGWIFDPQPPSNPTLHPHRSTPKRWNPSHPSLSHLQILNPISSGTYGTVSRALSSQTNTVLAVKQTPLSPTHNNGFPTPTLREITSLHTLSHERIVTLVEAILTPESVYLVMEYLPHDLQSLLASHPGRFTLSETKTLLSHLTSGLGYLHRKWLVHRDIKPSNLLLGPHGLKIADFGSSRLIGEPRPGNLTSVVTTLWYRAPEVLLGERFYGREVDLWATGCVFAELVKCVPVMEGRTETDQLDKISTVCGGFDAAWPKWRALSNAGLVKSSGKKKGALRDMFGDSLTERGLDLLQGLLTLDPEKRLSAEEVLNHEWFTEHPQPKDMTLFPSFPSRAGREKRLADDEPEKPPREKKVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9F8</accession>
    <name>A0A6A7C9F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase complex ARD1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_267628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9F8"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="201" mass="22846" checksum="4C3ABBFE244345B0" modified="2020-06-17" version="1">MDIKELESRDIPEVQQTNVTNLPENYFCKYYMYHVLSWPQLSYVAKTSDKGKVVGYVLAKMEEEPKDGVPHGHITSLSVMRTHRRLGLAEKLMRQSQRAMRETFNAHYVSLHVRVSNVAALALYKDRLGFRVVTIESRYYADGEDAYSMRKDLDNLEDAYSGSAQDEGDQVGDLGRTLQKVKVGRHLGVGELVERNEADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9T0</accession>
    <name>A0A6A7C9T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_254718</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9T0"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025671115" description="Quinate transporter" evidence="12">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2863839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="440" mass="48688" checksum="8E1F652B6D6899FF" modified="2020-06-17" version="1">MWSLIFLVGAGLMTGATGERGLGLIYGGRVLAGIGVGACSMIVPIYISELAPPAVRGRLVGIYELGWQIGGLVGFWINYGLSKTMAPSRKQWLIPFAIQLIPCGLLFIGSFWVKESPRWLFSKGRREEALKNLTWIRHLASDELYMVEEVALIDSALAEQSRGVGSGFWSPFRAVARSRKTQYRFLLGGMLFLWQNGSGINAINYYSPTVFKSIGVNGTNAGFLTTGIFGVVKTCLTLIWLFFLIDRLGRRKLLLVGALGGSICMWIIGGYIQGTDVTAGPKETSLGPGGIAAIFFFYLWTAFYTPTWNGTPWVLNSEIFDQSTRSLGQASAAANNWFWNFIISRFTPDMFDAMGPSGCGVYYFFASMMLLSIVFVWFLIPETKGIPLESMDRLFEIRPASSAHRKVHAEDAARDEEFRQDADGAGLDVAKERLERVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9X1</accession>
    <name>A0A6A7C9X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="36830" checksum="3188DF8FBC50AB86" modified="2020-06-17" version="1">MFGFLAPSSPYNPPSLVYTVLTQPVKTQVRFLSFFIALFRPRPVPGSPPIRLVCISDTHCVTRHDIPDGDVLIHAGDLTDAGTPAELQQQIDWLDSLPHGHKIVIAGNHDTWLDPKVRTILSSDDQQGTIDWKNVRYLQHTSVSLDFFHGKRQLSVFGAPQTACGNDEFAFQYPKELDAWTNTIPDGTDILVTHSPPKYHLDLPAALGDENLLREVCRVLPKVHVFGHIHSGRTEWIGWLRRGRETVKWDKGEKMVERALSRPDGLVRGLIHPRSWLDLARVAVYGLLGIIWEQLWGGKVRETIMVNAALMYDDSGKSEHTAQIVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA53</accession>
    <name>A0A6A7CA53_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA53"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="354" mass="39369" checksum="860FF154972B3D66" modified="2020-06-17" version="1">MSVVSQLFLNPALTAPLWLILTGRAPEGITQPVLLFLRRHLSADALASITTTLKWATVLGVGKWVNDWLGRLAMNSFRLRSERHRYDWPDEVALITGATGGFGSRFARDLAAKGVKIIAVDVIESMPQDDLRNNARINYYQCDITDRDAVMKLAEEVTEVHGDVSILINNAGVACEGMEVLTCTPDILQRTYGVNLVSHYYTLQAFMPAMVRRKKGHIVTVASLASFVSPAGMAAYSSSKAAVLALHETIRTEARALHKCPEIQFTSVHPTFADTPLITRWMKELQASKVFIIDPQQVSDAVVSQILSCRGGQVFVPRYTAATKWIRGWPVWLREGFVMMGERRRAILENGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA66</accession>
    <name>A0A6A7CA66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA66"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025641914" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="50078" checksum="DAF2664E5876A8D1" modified="2020-06-17" version="1">MNPGALLALPTSLLVSIAGADGASAQALQWPYNLPRNVKYFPEHEPLMKREAEVQERLTWQAPVGVRKMSHVDEGEKFFLQYWNLGEGLSSTNIWQGTNESLSHPLDAAVAPHRTPKRSIFARDFQCPQDTTSCTNIGSNLCCPNGQTCVSVGNGQIGCCPPGVDCSDSVRSCDTAAGYTSCANSPNGGCCVPGAVCEGTGCVFYGTRTVWAPPSTSTTQSAPSNSSASERVVTTTQIVPAPAPAAVTSVSVREHTITVTDDQKPSTIVSTVTITPTPRSEAAGAASLPYSKGSSTCSTGFVSCASSLGGGCCPSGQRCGSSNLCLSFADATTSSSSGVGAPIRPTSMSSGASLITTTAPGSCPTGYYMCSAYYLGGCCRVGRDCDTTSCPTNERTVVESGNAVVSVPVDSVAAAGGQGRCADGWNLCPQSVGGGCCPSGYACETTCRGTVSGMQGVAKETAASLGVKCHIGWGWGALGVGVLGLMIVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAF2</accession>
    <name>A0A6A7CAF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_209295</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7CAF2"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="500"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2864059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="699" mass="77398" checksum="72FAF02EF5151686" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAN7</accession>
    <name>A0A6A7CAN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_203962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cat_transpt"/>
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    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="90107" checksum="9C4624AE3733D803" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAY4</accession>
    <name>A0A6A7CAY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_254048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAY4"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2864397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="46518" checksum="43A4F8A17363A56D" modified="2020-06-17" version="1">MTNSSPAIHNADDQRPDLPRPYKCHLCDKAFHRLEHQTRHIRTHTGEKPHACSFPGCTKRFSRSDELTRHTRIHNNPNSRRSNKQQHATAAAAALQHSGLPPGTYDVNVLQHQQQPQPSTTHPYHAIGPLAPMSHGPVTPQTYHLPPPSASASRRNSPEPSPNMHYSAAPSAPPGSYLTRNISGEISQANMHSHSRPMDMNLLATAASHVESPGPAYHHSNAHHVTPARSSRFGYQSPYQRSRMPSLSSYHYTNTSNPASQPMSRSHSQDDDDSGRPYKKSRPNSPHSTSPPSPEPPHESASPTPDHTPLATPSHSPRLRPLYLTQGVYQLPTLHHLSLQHPPALAPVEPATDQTQTYVPTQHSGLRISEIMETGDGAQRKLPIPMMSLKDTGYAKMNDLVGNESGSGRASSRASEIAEERSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB05</accession>
    <name>A0A6A7CB05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_208478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB05"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="25027" checksum="C3FE047E7743B8AE" modified="2020-06-17" version="1">MVDAPRWKQTPPAMKMPFRLRPVPDQPEWKVNGDMETLDQWYDEFLRRVVSPPQRGRDILPEEIKWLAITHKSFDHGRRGFNERLAYLGKRFVDLQVSLALLKVPASKVAGAVAGLGGLEDVEPAPGAFQHGDLKRLENVSKRRLITSPRNSSRLAREYRMQEIIRWKPMRTDKLRTSGEDTVLASSLYGVVGAITLHCGASFAEKVVRDRLLSRWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB18</accession>
    <name>A0A6A7CB18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_208702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CB18"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
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        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
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        <property type="entry name" value="Hist_deacetyl"/>
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        <property type="entry name" value="HDASUPER"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="62749" checksum="4A4CAE91761281E0" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBJ1</accession>
    <name>A0A6A7CBJ1_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">K470DRAFT_3195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
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    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
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    </dbReference>
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        <property type="entry name" value="PUA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
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    </dbReference>
    <dbReference type="SMART" id="SM00359">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="290"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="388" mass="41708" checksum="4F606F0DE4C6DEC0" modified="2020-06-17" version="1">MKKHTTIVIKLGTSSIVDEGTHEPRLSILSSIVETAVALRRDGHHVVICSSGAIGMALRQMDLDRRPKHLPQVQALAAIGQCKLMAMYDQLFAHVRQPVAQILLTRNDIADRTQYLNAQNTFGELLSFGVIPIVNENDTLSVQEIKFGDNDTLSAITAGMVQADYLFLMTDVDCLYDKNPRTHADARAIEVVNDISKLEADTSSAGSNLGTGGMETKIVAARLATAAGVTTIIARSSRPGSIAAIVHHVEQQKAGVLPVQAPPLHTRFLPHPNPIRDRYFWLLHGLAPHGTVYIDAGAHAAIAAKAGLLPVGVVDVEGIFGQQECVRLSVIPNGTVGLNGAHEVGRALVNYSATEIKRIKGVKSGQISDILGYADSEYIALRESLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBN4</accession>
    <name>A0A6A7CBN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14142" checksum="DC20FA61CA390DEA" modified="2020-06-17" version="1">MPPTQPTQPTQLTLPLPSTGLKLHIHLTNLSSTLLLFLTSTGLDEIPTTPPMGPLTYSMPNKYNTNEPLSTRIYPGGGDFATRLAKVLVRRTGKLCFVGGGVDFPLGRASVEEEIAVLRAVVGVVCERVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBX5</accession>
    <name>A0A6A7CBX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF974-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_209297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10250284at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
            <end position="151"/>
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            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30058" checksum="47BFBC1A4B59F103" modified="2020-06-17" version="1" fragment="single">PYHTMLKVLRLSRPSLATQFVIPPLTGIGDGNLHIDPQASLAYPSSNEASSFPLTPLLTLPTSFGLAYVGETFTCALCTQHEDEIKVEIQTPAHPTGVQIEVDETQPDEEGDVKQSILRFDLQEEGSHVLAVTVRASDTGKKTRKLFQFVVQPLLSVRSKITKRRTDTTSKVSWVLEAQIENVGQTTTAVLERIWLSPNEKEGVREVPLSASGEDRPVLKPQDVEQVMFLVASEVEATATSKRLPLAQLNVSWRTAMGQSGKITTGWLVSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">PH domain-containing protein</fullName>
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        </lineage>
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    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2857122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="20967" checksum="786A5C712D136DDD" modified="2020-06-17" version="1">MHSRHSNPASSDLSLEPAGTSSSLLFSPHFIVYSVSKWDGRLKVKGKSHISRQQASTVQSPQPVQQHNVPVPTSALVLITRNPFEEKGKLLRDAIEKLPAEHRQFVQNQLGSNSNIERDAARVPTLRGQNQTKRSNQWIANMRKIACQIMQFAPVFDVATNAQADVLSLPWAGIRSLLMVSSNAVQLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        <location>
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        </location>
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            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF10680"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="48558" checksum="3227520A59C5BC79" modified="2020-06-17" version="1">MDSDFDSGSSVRSSRSTASSTWFHQNHDVVQLASSLDAQRAGDLAVHLYNAHMLKVRVRDIDASTCRPPNNKSLWSKAGDQPWQPSRSWTSWPLPPDRVPRNEERFTAYEYNYEYKPSADIEDEIQAVLMRQAKDKFNSRRWTSSVDQLDLQFQESTNIHPSFLIDDDEARKILGPSIRNIMDKLDQLLHNLQLSRQHHRIGTDPQANKHKSKPDTDPSISTTDSDEPPKGKPKQNPPPAPRDWSEVLSMAALSMWDPAIVQRSARRCADLFHENMSLRVMPERPSNAINDHITQYIPSHPNNPSEDENDNVAPVGTVIRKWLCPYETCNRHHKTLKDRGSWRLHMHNLHKLEYDKVDEVETSLWPVGEEVSTPRVYYGAVHNDGFMEPIEPFEEPTNKKIHGRRKRTGSTKGVRAEGADGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="84"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="873"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1180"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133006" checksum="6C178403E25E792B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQM9</accession>
    <name>A0A6A7BQM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006044">
        <property type="protein sequence ID" value="KAF2857422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="241" mass="27931" checksum="2A5999D81FDD7997" modified="2020-06-17" version="1">MSSLRNAAPRRTHRERAQPLERSKWGLLEKSKDYRKRAADHKLKRSKLKTLRTKASERNEDEFYFGMVNESRDSGSQNKKREQNGAAKKLSHDVIKLLKTQDAGYLRTMLGSVRAKRERAEERFVLQRNLMQNGGGEGKVVVLDEMPEESDGVVKDDDDLSSESVHDEREYETKAIKERRELKKKKHRIEVQERLVEGLKNREKQLGIALRELDAQRARMNGTAGKGVNKNGVKFKFRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQQ1</accession>
    <name>A0A6A7BQQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_260633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006035">
        <property type="protein sequence ID" value="KAF2857601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable Elongation factor 3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="1119" mass="123192" checksum="79B3787508BB4395" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23122" checksum="566B75A45DBD1BD8" modified="2020-06-17" version="1">MTMYLAAILDSSLPKDRRLTLKPEGLRAVMAWLDARYLADGLQIYGELMKFATNQDPLHEPRVLVENALREPAIRACSRFAIHNRSWSTFGHIHSKPRNRLKNPKVEKSVYIYSNSRTMGKINADNGPILWGEEEEEDVEEDTLPGESLDQPAQDMIEPPTSDEAIVEDEAIEDSQLVWLDDNEDDDEGWTLESEMLPEALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BQT3_9PEZI</name>
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            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit mitochondrial</fullName>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
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        </subcellularLocation>
    </comment>
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        <property type="match status" value="1"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR73</accession>
    <name>A0A6A7BR73_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">DUF1000-domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
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    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF5">
        <property type="entry name" value="OS03G0795500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19126" checksum="B1A4517895CBCB08" modified="2020-06-17" version="1">MGSKGIYSDVTSAVDQQGLDFLNIRGSARSIFADPSSADDNGKKAFIESDSDAQMMLYIPFANSVKLAGIRLVSAGEGAHRPKSLRLYTNRPNVLDFEEAEEMPTAQEVEVTWEGEKGTAELKFVSFQNLSSLVVFVVDAVEEGGEKTRIDELRLVGEVGMKRAMSKLEKVGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRV9</accession>
    <name>A0A6A7BRV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRV9"/>
    <dbReference type="OrthoDB" id="5076485at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="244" mass="24432" checksum="C7DBF04418CEFD28" modified="2020-06-17" version="1">MTLKIPKTVGPSADYYSIAVQDISKDNNPVTFSNKFHLDGADGNYTDYENKLGGAMFWDPNTLPCDSYDCARKCAMDNYPQDLNDKSAQGKMDACILKCPGVSMSDEVTNSQNGTDSSDAVVTITSGVVMTAIETTATTGGSTITEAVLGSNTLVLGGPAATISGEAVSLASGGVVVGKETAAFSGATESGAAATSGGSDGSAKESGAAAPSQSGKGDKKSDASKVVIAGGISLAAFVGALIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS27</accession>
    <name>A0A6A7BS27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNAse P, Rpr2/Rpp21 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_191513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS27"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="136" mass="15131" checksum="CBB7092AD7EF984F" modified="2020-06-17" version="1" fragment="single">SKHISARIAYLHKAAVYLTEQGHGQPAARTSNTPNCNLPDAKLDPNSGGLSLHLVKHMKQVAEKATIRLKPEVKRSICKRCNAVLIKDATAAMSTENQSHGQKPWANVYKIECRLCHAAKRFPIGAKRQLKKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSJ5</accession>
    <name>A0A6A7BSJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_222088</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSJ5"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2858062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="311" mass="35281" checksum="7C97D8514B5BEC5F" modified="2020-06-17" version="1">MQAHRTENWSKSKRQRMLQPYLPEQPTPISSHRRPRLRSAARNLLHYTIFTVVHILFSLFIRLRRLYHGSVDNLLSIYYHHHRTPGLIRADTKNLSKVPRHLSVILDLPPQGVKKERVEALARDAAELAAWCASVGIPQLSIYERTGTLKASLSLVHQKIEQNLEIYFGADSSTRPSLSVRAPHQTSCLPSRTPSRDSATSHLSVLLISMEEGRQTLVDLTRTLAGMAQEGRISPNDISQDLIDAEMTESVMDEPDLLILFGDRVVLQGYPPWPIRLTEIFNVPDHITGVTYSVFIRALQRFAKAEMRVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSK9</accession>
    <name>A0A6A7BSK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSK9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="66" mass="7789" checksum="920E0F6F736A2280" modified="2020-06-17" version="1">MCFGFSRWQDAETKKSKEIEKQLRDEQRKMQKEVKILLLGMFADLDPTTRLMSHGQERASLASRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTD8</accession>
    <name>A0A6A7BTD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_300811</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTD8"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025550802" description="Small COPII coat GTPase SAR1" evidence="23">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2858521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21551" checksum="4B45C912254C10EB" modified="2020-06-17" version="1">MWILDWFWDVLAQLGLANKHAKLLFLGLDNAGKTTLLHMLKNDRVALLQPTLHPTSEELAVGNCRFTTFDLGGHQQARRLWKDYFPDVSGVVFLVDAMDHERFEESKAELTALLSMEELEKTPFLILGNKIDNPSAVSEEQLRHELNLFHTTGKGKVPLQGIRPIEVFMCSVVMRQGYGEGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTM0</accession>
    <name>A0A6A7BTM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_272363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTM0"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="254" mass="27848" checksum="06272DE0E418CA8B" modified="2020-06-17" version="1">MKLNLYVPPQASASTPVPVLFYLAGLTCTGDNGAEKGFFQHAASKKGIAVVYPDTSPRGLGIAGEDDSYDFGSGAGFYVDATKDPWKKGYQMYTYITKELPEELLSSFKELDGNRMSITGHSMGGHGALTLFLKNPGKYKSVSALAPIANPSQCQWGKKAFGGYFGENNKDEWDSHDATKLISKFPNDTDILIDVGTGDNFYKEGQLLPENFQEAAKKAGKGVKVRYQDGYDHSYYFISTFADDHVEHAAKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTN4</accession>
    <name>A0A6A7BTN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_289483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTN4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="200" mass="21768" checksum="AC71D9BF89507CE4" modified="2020-06-17" version="1">MWPNMNIMNEGPSRGSLHPSFGSLRPVGSPAPGSVLSVRTVPTPTRTPTAASALTVAAAEPTAPYIKGRHTVGTGQIVYEVYQPGKGTSTVSLEDVEKYIPYEVLERFEHARIREEEFNFPQPKRRASKGSAKKSRGRKPVPITDDEYEDGGVSGDGDNATGKGADNEKDEDVEKAYFYNEEPEENLSDINPGEQAKVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTU7</accession>
    <name>A0A6A7BTU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apses-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_251445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6718656at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="685" mass="74438" checksum="E6305CA6B508C51F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU33</accession>
    <name>A0A6A7BU33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_220615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU33"/>
    <dbReference type="OrthoDB" id="2119662at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="476" mass="53223" checksum="D9072B069BD471FD" modified="2020-06-17" version="1">MAEVSEQDAKPSRPFTRKRYLGTLLFNLAAFSLPALYATLSKLWVADIDSDMVATTDTFTYIGIIVEVINEGLPRAAWTVIGDKTNRPIADRHRLSYTLILVQSIFGLILSVVFVAAAEQFSSAFVPREIRHNSLTYVRIAAFSSLASAIEYATANATRALDQPDVPLLISSVKFIINIILDMILVSKFHVHGITPTVNTQAATQLACGLAASFAGLAYFLITTFRQRRSGEPVRPSFMALKDLAKPGVYTFAESAIRNALYAWLVSGIVKMGLDYTTAWGVFNTIRWGLVMVPVQALEATSLVFVSHAWGRWQAQPASRASLSRFYPLIYPPLLSCLMVLIFEVPICLGLSFSGAHRFAQYLSGSIKVSLITQKMWKSIDWCYIFYAVSTQMATLLLATRPRWYLYQSLISNLCWVLPWAIVMAKININPDNAWSYHAIVFGGSLVFSFADILIVDVIWAWRILRERRVQRAQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUP3</accession>
    <name>A0A6A7BUP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_259848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUP3"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025711156" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="151"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="368" mass="40730" checksum="DCDC44A54F401217" modified="2020-06-17" version="1">MKGFFQLTVLATAASALTVPQPVEKFHIEVSPGNTTWVTENEKWNLRRQGVNFFDITNHDLSEKSAVIHAANAVTYPDQPTQSSHVQPLLKQLDKEQMRSNLETFSNLFNRYYKSDYGRQSSEWLLKRVQDTLGEVGNAKPFKHSWGQNSIIATIPGKSAKTIIIGAHQDSINLDGPMDLRAPGADDDGSGTVTTLEALRVLLTDDGIRSGQAENTIEFHWYSAEEGGLLGSSDVFKAYQSQGRDVKAMFQQDMTGYNQGTLDAGKPDSLGVITDYVDSGLTDFIKKVVNSYCTIPYVETECGYACSDHASANKAGYPSAFVIESDMKLTSTYIHSERDTIDRLDFDHMIQHGRLTLGLAYELAHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV09</accession>
    <name>A0A6A7BV09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UEV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_195288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="462" mass="51859" checksum="633FD1FEA0DE4D3B" modified="2020-06-17" version="1" fragment="single">LLAWLHNALLEYEDRQKAYADVVNALSRERSLRPRMEAYTAENGTSSLLLVLAGTLKVNVKGVFYHFPVSLWVPRLYPHEPPLVYVTPRQGTTIQPGHHVAVDGRVCHPYLRDWGQSQGRASIVEFLDILTGVLEHEQPINEAGPPLPPKGYNSDKKVAHSQGLPPPRPPKPWGARQQTEQVEARYRAPLPLPSQVLPQQIPQWTSLQRQQRYLQSPQQLPLKSHSGLPTHYFSFYRPEFQSRLFQLRADSPQYPRPNSREIHSSDVSHRARKAPQDLLSDAFEKSQPVVENPIPPIAPNPEKERLLQLLSTSFAAQARSKVDQAKTAASDLQAQAQALTKAQSRLESELAFLESLSLTLDANERILHQAIADCERTAQLAGKKPEPPIDEILLAPTTVENQLWSLCADEAACREAMGVLLPALDRGRISTEVFVKQMRALSREAFQKMALARKCAHRLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV34</accession>
    <name>A0A6A7BV34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A-pheromone processing metallopeptidase-like protein Ste23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_300794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="392"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="781"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="931" mass="106592" checksum="C2B8F46F345AC5DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV42</accession>
    <name>A0A6A7BV42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_282835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV42"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="336" mass="37884" checksum="8AC44C0E8D786573" modified="2020-06-17" version="1">MTDKLPPNLRALFTARPPLRYIPPCDYPLEKRATAQITGVGAFLSMLRDEESAPYTPTESQMQKRDREKREKQTRHDWLVNEGVKELYKPHEDPKISGDPFRTLFVARLPYDAKENDLLAAFHRFGPIARVRVVTYAKPDAKEDKEEQEKDVTRTTKPKDRTGQSRGYGFVEFERERDMKAAYKETESFSIRGRKVLVDVERGRTVQGWKPVRFGGGLGKRHYTKVVPPRPHGYGPPMGPGGFRGGFRGGFNDRGGFRNRGGPRGGGGSGFGGYGRGGSVPGGSRSGIGYGRDERRSANYEPLPPRGSYRDRDGGYAGQKRSYEGGYDDPRQRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVC7</accession>
    <name>A0A6A7BVC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_219814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVC7"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="422" mass="48523" checksum="6163D96E1BA68C4E" modified="2020-06-17" version="1">MNGKPATHSQPSRKGKKAWRKNVDLEIVESGLERVRQEIIQTGGVITEKPENELFATDTAGDHSIGQKLKGKELKCDEILKQRSAVPGLDGRKRKVPPTPTPSDRYKRGNYVPHRELTRLRNVADGGVEVQVEEHVYDPWAEQEAPADGFVAPVRPKVEPKTLKRAPLPLTADGKGVRDVLKPSASKSYNPAYPDWQASLQREGAAAVEAESARLRAEAEQKEKEARARAEAERVEQWEREDDEYGTEWEGFETEDEQPHTTKQPRRKTPAERTKIKARKLREAEERGKKKQKMREAEEQRIAQIAKEVRRRQLGDGKDRAENGKNLTENGEEEDKTDEVVLQKRRFGRLPVPEAPLEVQLTEDLTDSLRRLRPEGNLLTDRYRNALINGKLEVRKRRDREQHKQAKKTRTEKWSYKDWTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVM9</accession>
    <name>A0A6A7BVM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_196296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVM9"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="316" mass="33819" checksum="9F61AD199EE4A85F" modified="2020-06-17" version="1" fragment="single">TFTYRLGVASSSKWSPPRMPVLGQDFFHYSNEPLVPSKAAAGEDGYFAASVANTRSIAFGVTDGVGGWNDEGVDPSVFSHSLCKAMIGAAQAGINRPQAILQTAYDEVMADDAVVAGGSTASVAVADAKGCLETANLGDSGFIIFGPAKVMHYSDPQTHAFNTPYQMAKLPPHVRRQHAIFGGAKHFSETPAQAAVEQHRLSHGDIVVIGTDGVWDNLSAQDTLGVVTGVMEQHGFWNKAILNNTKIRESHEIHLPTVLATAVMRTAKTAGLDTRRNGPFAREFAKEITRKHPDERWKGGKPDDIAVVVAVAVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVU1</accession>
    <name>A0A6A7BVU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_100606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVU1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="176" mass="20069" checksum="560B3F65E899E74D" modified="2020-06-17" version="1">MQSKSLNEVHWGQPPSVLCSPLFQKHPRAACRARDAPCAMIIRPCYIGRQMRRGLLFSQRRFSMSAYSRRMVYKFMSGYCNEGEWLAFRSRPAPIRPRVDASRGVESGCSLKFRDARKKRCCVPRRPHTRNGTGVIGHFSSAIAVQGRVLRGPLYSEGEGFFYEVLASSFPTLRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVX8</accession>
    <name>A0A6A7BVX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">K470DRAFT_272065</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVX8"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF2858889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="813" mass="91081" checksum="0D56F477CE589375" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW26</accession>
    <name>A0A6A7BW26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_277621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW26"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="322" mass="36157" checksum="AF95AED7CD84207E" modified="2020-06-17" version="1">MTPHRFLTSHPKHDTSPPAPKFQKPSNKRSASPPSTQNARLFQKRAVEETVPQPPPFLRSTQPKRLSEQFTSTPRFASNKEEKREVVNAFRTSTQAEGVDEDAEMLLTTTPLHTTLPFSPKRPRLAFEDDISPIHRSVSPTQETVSDELISPKPYPPQTPIPFHLQPSQSSRALFKHTESTHPEPSSRVLFKPPSHPPPPPITDAFSPRKRGRLVPGGMAATVQTFILDAPYHSHEEVVFKVRQVERGPPHFIRTMDGRGVLLVAGRVEIGDWVELKPPTWDVEVNGEGWIVGVEYTIQGGKMTIVDGYRIPEGREIHNGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW71</accession>
    <name>A0A6A7BW71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_278308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW71"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="190"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="862"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121323" checksum="CB20D237B891A015" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW94</accession>
    <name>A0A6A7BW94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_220028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW94"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2858985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="427" mass="46399" checksum="046AEDE4019E9C2B" modified="2020-06-17" version="1">MTISNPNVPSAPVTPINLKPTYSLSTVAVHGDDTLASATDVAPALHVSTTFRYPSDPSRLIPESEATTQRSPEGPVQGDTHVYSRHTAPNSSRLELSLSRVVGGPVLTYSSGLAAFYSLMVYLNPKVVAIGAGYHGCHGVLNLIKKLTGCKIVDLFDEGAWEGLGKGDVVHLETPVNPTGEAYDLSHFANLAHKRGAYLTVDATFGPPPLQNPFKHGADFVMHSGTKYFGGHSDLLCGVIAISKLREGWEQHFWHMLQERECLGNVMGNLEAWLGVRSVRTLDLRVKKQSETATRLVGFIASALGVSTEGEKPSEEDAAIIKSTVAKVMHASLQVQDNPWLKDQMPNGFGPVFAFHLKTLSYAKELPSNLELFHHATSLGGVESLIEWRAMSDNTVEKTLCRVSVGIEEFEDLKHDLLNGLKKLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWX0</accession>
    <name>A0A6A7BWX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_271277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWX0"/>
    <dbReference type="OrthoDB" id="427924at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="64" mass="7070" checksum="20FC1A4EFA7B5768" modified="2020-06-17" version="1">MAFQDSRPIAVLSKGLSAAERNYNTSERELLAWMPRASPVSQIARQGYQTIEATFAELGKPFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX46</accession>
    <name>A0A6A7BX46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_282552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX46"/>
    <dbReference type="OrthoDB" id="5317242at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025391998" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18652" checksum="5029FDCCD9EF14C2" modified="2020-06-17" version="1">MRFSVLSLLVATASAATFITDARDFLLVTTTQIDGSADTSKLANVSATTLFNPFNQEEFLLRLIGPGYGYLSRFELTDSDLHTLARKPHSNSQVEYNSTGPVKEHSQLAFAPRPDAPGGNIAFRDGYLLTVNGDPEGWSICHGPMGQSVIYWKGSDSSCVPTYLQAASNPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXE3</accession>
    <name>A0A6A7BXE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXE3"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="124" mass="13852" checksum="1E5B43D10871731A" modified="2020-06-17" version="1">MLDSGSGFGDIHLWSHLRRNGPYLALLDVLFANIFFTQWGLVLAGAADFTRPAEQLSLSQNAALMATGAIWTRWCFVIRPQNMFLASVNALLFCVGTTQVARIFLWKREMEAKKQDKGVVAFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXR2</accession>
    <name>A0A6A7BXR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_259055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="214"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859298.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="800" mass="86912" checksum="CF7802F5A44A6800" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXT8</accession>
    <name>A0A6A7BXT8_9PEZI</name>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2859328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="326" mass="36814" checksum="AD0F06B039512898" modified="2020-06-17" version="1">MSTFPPTLGTALLPHLLAASIPLFSLLTINHSWSYFILGCIWSAAPLKQFLHLLPSRRPYYASKVRILKICTTQTSAHHAATAGLHFSATELEALSLSDEGYIGFWRWMQYFPSTLTRPALGECVNVERLEIDVLWVFWDLGRVMAFVDACRGLRSLRVEGRGARLGLQYEFLRCLEVKRGLVEVDFGFVVHLGAERDVMALPEWEVEEKFRSLERARMRVRGEDVLFVYRVARVVENLRLLVCTPEPRGGLVVMQAIEFLPVLATGNLRTDEVLGRITTLRELVVIGNESTLILVDDRAFLALVRLGKELRLLTLKSDGVGMTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY08</accession>
    <name>A0A6A7BY08_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2860256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="7803" checksum="D8395C83B0BBA87F" modified="2020-06-17" version="1">MLPYTLEHANNLLANDRASWRKPFQKDWQRLEMKAVSDESLRKYHTNPVHWLCACPIHLQSRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY26</accession>
    <name>A0A6A7BY26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_295220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="39331" checksum="0C3C6200C3243EE5" modified="2020-06-17" version="1">MVVESKFDPKDMIFRHLGPTGLKVSVLSLGGWLTYGGTQKGSIVKDCLESAWSHGINTFETYTAEIYSNGESEVEMGNALKELAWPRDEYVLTTKVFFGTGRKEPNTRGLSKKHIVEGLKSSLKRLQQPYVDIVFAHRPDVGTPMKEIVEGFTQVIQNLNLAYYWGTSEWSAAQITEATQIAERYNLIAPVVEQPQYNAFHRERFEVEFAPLFEQLKYGTTIWSPLASGLLTGKYNDGIPEDSRFANNKAFFDSTIKSLQSEEGKAKIEKVKKLAKVAEKLGSSVSTLSIAWCLKNENVSTVILGATKVAQIEENCKAIQLFEKLTPEVMEEIEGILDNKPTPTPDYGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY42</accession>
    <name>A0A6A7BY42_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
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    </gene>
    <organism evidence="11 12">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY42"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2859907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="477" mass="53463" checksum="FCBFBF14F775357B" modified="2020-06-17" version="1">MSSTASSRALDYLELLPGTTFLKLYRQPSTCLAIFRRMLPHLAKTLVMALLYMPEPLSRSDLHMWFKNDNASSSARTRAISILQRLRILFDARDANSKSAYVLSTEFSKGLRLALTGGGQHYSFGVPSHTPDTNPPDIADLDIFARQRWEAILYFVAGSSGLGFVDTVRPSASTKQVLTDARFVAGSVNSPRITKEGFEFLLQDVNTQVWTLLIKYLSMADKLDMDQVETMTFLFMLGSAELGMGYALPAENEHSSNQSKLLSDLQDFGLIMVRGERYYPTRLATTLTNDAPALLSTTSGSGKGEGEKGFVLVETNFRLYAYTSSPLLISIIQLFAALRTRYPNLITAKITKSSVRRAMEAGITSDQIISYLQTHAHPIVRRQVPSLPHTVVDQIRLWQIEGERMVTNSGYLIRDCGSEQDFNKAVEYADKLGVLKKTFKTRGSFFVTRMDQMQEYFKAEARNKKEAERKKTGGRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY68</accession>
    <name>A0A6A7BY68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY68"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="111" mass="12948" checksum="885B7DCA81922D14" modified="2020-06-17" version="1">MTTTRSHGLRKNGHQWLPAKRPFRPSVIKTTGASAFAKRTARQAQEQEAKRMENEMKAEKAAERAQKAQAIRDKHSAKEEKERFEKLAAKMHKKKVERLKKREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYE6</accession>
    <name>A0A6A7BYE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_271437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYE6"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="502" mass="56500" checksum="B41C8520D1C3CB1E" modified="2020-06-17" version="1">MLLKLPSELLFNVVDFVDDANDLRNLARVCKRCQAASEPKLYELIFLRTPAQLRGLLASLRGQPAREEAIKSVDARFQSFNDDNAFDLLGQLLGQTPKLGKLIIESPYCHGRGRFISERGPADWSDTIDSWLAPLISSTLLSNVSHAMLIEQPLFTLTKLTLHLSGTERDYCVFRGWYGAIFAHSTLQDLQISNVILPDEVCSNVRSTKTPLKNLTLAEVSITSKALHDILSFPRALESFELVENQYSFEEQEQPYEDQQYCALTVRDLGQFIKSLQQQCASLQTLCYVSQAQELPGPVKTAVGLGNFVSLNRLILNDHPHVIDAIFLRGFPIPPKLAYIKLYGLRDDLFFKDEYLWADSPRPSELNIITALAATISSLSELNVMLRTDDEWYSGDDSEWEETKQVMRATGELLVQRGCSFALIWSREGGQHCPKLFDEPSPLETVTFRHSPSKGVEFDFLSDGPSSAYETDGTSGGEYEQFGWSSAEEDYDDDFEDNDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYF0</accession>
    <name>A0A6A7BYF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_198321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYF0"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="89" mass="9851" checksum="4D761BD579F830A5" modified="2020-06-17" version="1" fragment="single">GNTPLHYASANGHAYLVERLITDGGMDIKIRNKEGNTPLHWAALNGKLESVKVLVKRDKTAVWEKNHAGFLPVFEAERNGQEGVVVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM2</accession>
    <name>A0A6A7BYM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_282221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005984">
        <property type="protein sequence ID" value="KAF2860203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM2"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="358" mass="40011" checksum="A5DCF9E8D63A5BCD" modified="2020-06-17" version="1">MEKRTTLIRPPPPSDHRAPIEEALALTRLEDIDPNLFTNTRPLWHPPGARGIYGGAAIAQCLAAAQRTVPEGFLVHSMHCYFVLNGNSEIPVIYHVEHVREGRSYATRTVQARQRGQAIFTTTISFQREGSGGKQTLFHAATMPADVVPPTDISQLRDPSGLSQPFISIPAPSANPDSAHHHEKRMRQWIKARGRISDEGGRAAHTTALAYMSDSYFIGTVSRAHRLRRFDPRMADSGQVARLLKMSDQELREQARLNDEDIQHLRAIKLDEEGYPVQEENVELGPQVGMMVSLDHTIYFHSPSDFRADEWLLAECDSPWAGDGRGLVHQRMYTQTGKLVATCVQEGLVRLKQDGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY3</accession>
    <name>A0A6A7BYY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_217081</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY3"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="341"/>
        </location>
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        <location>
            <begin position="682"/>
            <end position="991"/>
        </location>
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        <location>
            <begin position="1001"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860451.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114867" checksum="074145AFF727EE5A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ48</accession>
    <name>A0A6A7BZ48_9PEZI</name>
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            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">K470DRAFT_217007</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="286"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2860510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="316" mass="34733" checksum="2107DF7FB691BDDB" modified="2020-06-17" version="1">MKLLYPTSLAFDPTKLEGFHTELHPYDPKKPLPENLIDAEIMLTWVNSPENLTDAVKRMKNLKWIQSLAAGPNDLLSAGFDPKKIKITTGSGLHDRTVTEHTLGLLLNAARRFYEMRDYQLEGKWAGHLGGAQPARPDDSFRTLREAKVLVWGFGSIAKCLTPHLTALGAKVRGVARHAGIRNGIEVFSDEKLPEVLPETDVLVMILPGAKSTRHALNAERLKLLPKHAWVVNVGRGTIVDEDALVNALEKGELGGAALDVFDPEPLPGSSKLWKLKNVIISPHAAGGRPLGAEELTARNLRRFIAEQTLENILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZF1</accession>
    <name>A0A6A7BZF1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_69032</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZF1"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30735" checksum="409556A0EAD0C4F6" modified="2020-06-17" version="1">MAATDVRSLLRAEHNNRRIVHPNAIYTADGKLHCTVCAAPVPSTSWKAHLHSAAHLKHQSVELNPPTTEAKHEVRDRDLSPVKKKRKLEISSPEVAHVEQKRVKASPPWGDNVEEEVLKELPQQTAQPREADEGPMQAEELAAFEAELALMEDHQDKTALDVEATISAKPLSAEEIAAKATEEQSQQRTKTDLDIEGEREDALRAIEEELDTMEILDLRVKKLKERRAKLMKSKEVEVDEKAEVEDDKQDEDQDVDDNSDDPFHDWDLNSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZG7</accession>
    <name>A0A6A7BZG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_257986</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C025"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="17296" checksum="2C22F52F271B605C" modified="2020-06-17" version="1">MLDAFSSSSRHDCRACTVRCIPRARSQHTALCQPLCRPPQSESTPLSRREDPEWPRPRIVFPRHLLTWPRDVHPISFQDLPPLTPQLGGATSCHPHLRLHLPFASSRWHNACAVERVCPPLFQLATSERLLTRARRFGQAEECSFRGCNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0F7</accession>
    <name>A0A6A7C0F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_246445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2860873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0F7"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="552" mass="62342" checksum="A1FBEB097F3E52EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0S4</accession>
    <name>A0A6A7C0S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_202031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0S4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="88"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2860535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="474" mass="52745" checksum="DA1015ED6D9A4175" modified="2020-06-17" version="1" fragment="single">AKYEFNGEFGDVLPEIPALEEILFDRKVVGPRGEHFANLPDNVVVEGPKKISPVNKARFVDAGLHPVVVENTKKVGYDDCTPIQRYTIPAVLQGSDVVGIAQTGSGKTAAYLVPILSNLMGKAKELSGPKPGLNGVGSTETVRAEPLVVVVVPTRELAIQIFDEARRMCYRSMLRPAVSYGGFPLIRTIMDLKKGCDVLIATPGRLCNLMEITETLSMSRVRYTVIDEADEMLQDDWNDELHMVMSGGDRQKHDDHQFLMFSATFPGPTRRLARKHLSPNYVRIKVGRVGSTHINIQQKVMYVDGREKQSVLQDMLLQSDKPCLTLIFCNSKAMVDTLDQLLWEQGLPTTSIHGGRGQREREDALRAFRTGRCPILVATGISARGWDIKGCEHVINYDLPSASSGGINEYIHRIGRTARIGRLGRATSFYNERNEDLAPELVKVLIECGCEVPDFLEQYKPEGELDFEDNSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C160</accession>
    <name>A0A6A7C160_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33203" checksum="07F48988BD1A2274" modified="2020-06-17" version="1">MSSKGQPFISLIPPRRQEKKPPSAFFGQAALHNVLRDQFSLATWLCMGAVLQGILYMTIGRLSLLPACSLLLFKTLTTAGTSLCLLRNPYMDRVILNKISTQIPDDHGQQGTKPANAELVVFLIGIQVNHPLGILAPGVKATGDYFESMTRDLDDKADEYGFMGMTSWLNGSDRESKNMLLNVCYFRSVEGLHEFAHDALHRKGWDFWNKIYKTHPHITLYHEMYHVPRGNYESIFINSRPSLSGTNFTSYTDPKTGEKMWASPVVDASKGLLRTSAGRMSRSDATENDKYGPGSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C199</accession>
    <name>A0A6A7C199_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Piedraia</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C199"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="34349" checksum="8225A901A6440182" modified="2020-06-17" version="1">MTSHSFDDEEALDRQLYAMFANFRAEELGNPEVREEHHELDERLERECESRDLTDGVEKGELLCKVTTSEDDFIEMLTIPILIDLQDLSSVGKKTGLVRKQVLGDSTRRIGQRCSQEKAHVFTIRILKSILEAKAILVGYMRSESVIDLTVGDDETCQNLMGILSESESESGENEELSIGEPENPAVNDAVLSENGLDEHEIEENLCGRLRLHTLSRFPASAMKNLVDLRLIQRLPLAVVQEAFPGKMPAKEKWDMLSASVRPRTLWSLTEIKGVIRYFEAHRLSLEATAEQLPERSITAIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1M1</accession>
    <name>A0A6A7C1M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00412">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="466"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="825"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
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        </location>
    </feature>
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        <location>
            <begin position="627"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1063"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127785" checksum="737BE2502153CCE1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C203</accession>
    <name>A0A6A7C203_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_202784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C203"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="190" mass="22138" checksum="D56618F6E310CCD0" modified="2020-06-17" version="1" fragment="single">DISTLGHYELAQHRELREMIRVAAWDMPLLSSLAKPFERDPSHFLRWRYTTYMGEAHPGAAKVVVEFRPDELPGLNKDELHALLLIAAQRYNPVKGVIKMSSDTYPEAAQNKRYLGDTIGKLIAEAKANAEKFKDMPLDTRHVRKPKYVKRRFPEHWRLTEQRREQLLAERKEQELEEGKRVDHSRIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2M2</accession>
    <name>A0A6A7C2M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_214438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2M2"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="587"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="696"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2861724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="813" mass="90157" checksum="A3A61B30F19D42AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2R0</accession>
    <name>A0A6A7C2R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DUF663-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_214667</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2R0"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="585"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123941" checksum="04CF623DB2ED0A46" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2V7</accession>
    <name>A0A6A7C2V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside phosphatase GDA1/CD39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_193696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="419" mass="46480" checksum="754B1451CA9823C5" modified="2020-06-17" version="1" fragment="single">KHRYGIVLDAGSSGTRIYVYKWETTGVEDRLPHITTHKKWRMKVHPGISSVSSGNVATYLQPLLDLARDVVPPEQASQTPIFLLATAGMRLLAEEQSNALLEETCSFLKTSSFWLPDCNRHVRIIPGETEGLYGWIAANYLLGGLDAGNRTFGFLDMGGASAQIAFAPNATESAKHSNDLTLLRLRTMAGKMHEYRIFITTWLGFGANEARRRYVDGLKEATPEGVVLDPCLPVGLSVDGLEGTGQFAECLNKTYPLLEKDTVCLDEPCLINGQHTPAVDFGINRFVGVSEYWHTTHDVFAKDKAFDLASYQKQAHDFCSRDWKDIMVDVGEHKWGKKVDNQTVANICFKASWVMNMLHEGIGIPRMGLETSPTHKNTTKAVLDQAAHRGFIEPFQAIDEIDGTEVSWTLGKIVIYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3I3</accession>
    <name>A0A6A7C3I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_243739</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3I3"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="100" mass="11850" checksum="7DDE95B03712686E" modified="2020-06-17" version="1">MSQTARVLKLYRRSLKLALDWTIYRHLWRGQAVYIRSLFDANRHITEPNQRRELLDQTEAILEKWKHPDPYRPPTAPGGSKYERNLPLHNTNPPPEGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C470</accession>
    <name>A0A6A7C470_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_213052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C470"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="206"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="54033" checksum="523F66BD353009DB" modified="2020-06-17" version="1">MRFSDWLTEWTPVILVTSYWVVCTAIFVMCNEPAIRFFYYFYMVVNLYIAVCAAVESFLGLTPVRDAAMAADKADATGKFPSSDEALPTLDMVMVAYLPNEKDIVVGQVMYALEELKYPREKLRINLVYNTPKPIEPVETQLRELDEQYDQLRVIKVPNSKSKADNLNHFFSLPPSGADYTGVFDTDHCPHPYNPRWAAERFILDKPDIVQGRCIVYNTNESFWAKMIAIEFDKIYAIAHPGRSRMFQFGLFCGSNGWWRSEVLRELKMHGEMLTEDIDSALRAYGDGNRAVHDMNVLSYELAPNSFGAFWKQRMRWTQGWTQASIVHLPLIWTNPPRGHRVPQERLGLFSLLFVRELSYYFVSQHTCLLLSFIITGWPNDAGSFVRLIFFRYPMAEWFLFITILCLIFTLWFTDRVRSEFTSWRAMIVFSIIYTPYLILQSTMGLFGHARELVKYSSWNPTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4K6</accession>
    <name>A0A6A7C4K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4K6"/>
    <dbReference type="OrthoDB" id="3784117at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="39996" checksum="3DE6787B0AF492FB" modified="2020-06-17" version="1">MDESELIVSPPASSQGSPKSSKFPETRIMVSSGANKGDLQAIVNKQAAALQALHDTLEKQRKAFAEERLALQMQITHLKQLFGLDNGSVGSNNVPSFSFVKDSPALLTNGEAENPRRSSEDGGTIPLHRRRNLVVPPMKRKTSRDDNGFVTERHNDHLAVLEQPSPLLLSPLPPGNRIYAGHTPPVPLTPSIQVDTQDCERDTPTRNNTDINHKLTQFTKEDEDKGLSGPLTLENKPSRSGPGHIRFDDLVRRMEEIAQESQRPSVFANPSPGLASPVEEPEQIDQPSPIKSHNKEEHLASNAAIDSPRNAVELSESDTSPLARTLSKQKEIDIAKHHAHLKECGIIPKKDLSLNFGAPLGHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4N3</accession>
    <name>A0A6A7C4N3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="446168at2759"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RFC1"/>
    </dbReference>
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        <property type="entry name" value="RFC_lid"/>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
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            <begin position="127"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="831" mass="91434" checksum="27A5CEADB4BDE249" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4R5</accession>
    <name>A0A6A7C4R5_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_243927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="356"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="448" mass="50888" checksum="6DE87CC59D3DF2E0" modified="2020-06-17" version="1">MKIKALSRSTSRVLEPGSDVARLPRNLNPALHPFERAREYTRALNATKLDRMFAAPFIAQLGRGHVDGVYTLAKDPNSLERFASGSGDGVVKVWELSSREETWQTRAHENIVKGICWTSDKKLLSCSADRAVKLYDPYNSSSDCAPCATWLGSNAYTSITHHRTEPAFAVSSASGIQIYDESRPSSVPKQSLAWPTSVDTVNVAAFNQSETSILASCATDRSLVLYDLRTDSPLHRSILTLSSNAISWNPMEPFNLALANEDHNIYLFDMRNLSRALNVLKDHVSAVMDVEFSPTGTELVSASYDRSVRLWNRQEGHSRDIYHTKRMQRVFACRWTPDARYILSGSDDGNVRLWRAQASQRSGIQTSRQRQKLELDAALRERYKHMPEIRRINRHRHVPKQVKKAGETKNEEIRAIKRRQENVRKHSKKEGRPGRKSEREKMVLTTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4S2</accession>
    <name>A0A6A7C4S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="14"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="346"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="12">
        <location>
            <begin position="534"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="912"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1379" mass="155390" checksum="35A96DD0DC15788A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T1</accession>
    <name>A0A6A7C4T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_256100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4T1"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="346" mass="39260" checksum="4E419667C4899129" modified="2020-06-17" version="1">MSAAHTTTHLRRWVRSLPPIEWVIYQVRSILISTLALGPVPAHIAFVMDGNRRYARQRALETVEGHNLGFEALARVLEICYKSGVKVVTIYAFSIENFKRGRAEVDGLMDMAKTKLVQMAEHGALLDRYGARINICGDLSLVRSDVLEQIERAVNMTKHNNKKTLNVCFPYTSREEISHSIRETVKQWTIPVPKTVDKRDALREALIERRIREQHNPLLAETVEESSDSDASCGAENEDSIVQSSATSRTSAPSPTPLEDGGNGERKLCLPDPEKISSSDLDRNVYTADAPPLDLLIRTSGVYRLSDFMLWQCHEHTDIRFLDVLWPQFGLMALLPVLLEWQWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4T6</accession>
    <name>A0A6A7C4T6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_212563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4T6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="33952" checksum="B20613FC52E81BED" modified="2020-06-17" version="1">MSDVPHFFTLNTGATIPAVGLGTWQSGPGEVTAAVETALKCGYRHIDAAFVYGNEVEVGKGLKAAFDAGVCKREDVFVTTKLWCTYHRTPEACLDESLKRLGLEYVDLFLMHWPVPMNPSGNDPIAPKLPDGSRDLDKEWTHVKTWKAMEKLPKTNKTKAIGVSNYSVKFLEELLPQCEITPAANQIENHPLLPQDDVIKYCNVKGIIVEAYSPLGSSGSPLFSEDALNEVAKKHNVGPGTICISYQVNRGLVVLPKSVTPSRIEENLKTVKLDESDMEKLNGLHKKKGVTRFIYPPFGVNLGFPDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C539</accession>
    <name>A0A6A7C539_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_256661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C539"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="300" mass="32683" checksum="E58D18BE517A3C5C" modified="2020-06-17" version="1">MAQDDVVGSYRTLSRDVSPPVAAIQVLISSISNTQPSTASETLDLISKHISSLETAFPNSISLSAGTTLLKQYVITTLQREAYQNDDFAVVRQKLIVESEAIITRIGTASKLIAQFGPKFVCDGDVILIFGRSGVVDALLDRAADKKVFSIIYVVEGDGRGVEREVEMLRKKDIRVAVVPPTAVAYAMHKVSRCFVGAEAIVENGGIVAHLGTFQLALIAKTMGKPLYVLAESHKFVRKYPLRQEDLGIEQNIVDFGDSKSDLNEEKVDYTPPEYIKGIVMETGIQLPSAVGEELISSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5C0</accession>
    <name>A0A6A7C5C0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_262957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5C0"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="782"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="955"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
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            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122780" checksum="0CA519235CB5CE7F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5D0</accession>
    <name>A0A6A7C5D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_256148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2862165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="309" mass="33281" checksum="2F2530067B8419E7" modified="2020-06-17" version="1">MSCDANPDPTIREFWSSHRQRRLQPMQLPTPSTSHVNYAHVYEPAEDSFLILNTLSSPSETAFLRSRFPAPGSPSPLLLEIGSGSGVVVAFCSAHAESVFGRRDVFALAGDVNPYACRATAETVRLAAQATTKVITGATADSTAESTTEDSTETAATATTTTGTGCFLSSLTSDLASSIRANSVDILIFNPPYVPTEELPNGSNCDEFADRSDFSSQEEFERNSYLLALSYAGGNEGMEVTNCVLDALTTVLSDRGIAYLLLCAQNKPETVMKRVRGWNGGGKWKAEIVGFSGIQAGWEKLSIVRIWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5F4</accession>
    <name>A0A6A7C5F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_275071</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5F4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
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        <property type="entry name" value="CYP120A1"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
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        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="503"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="682"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2862714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119179" checksum="F9868C774E4B5DF8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5J1</accession>
    <name>A0A6A7C5J1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_256509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5J1"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="300" mass="31936" checksum="3981C5FE48AD59F9" modified="2020-06-17" version="1">MATTTAPNGSQPDRLKTGLAQMLKGGVIMDVVTPSQAAIAERAGACAVMALERVPADIRADGGVARMSDPSMIASIQAAVTIPVMAKARIGHTVECQILEELGVDYIDESEVLTPADDKYHVEKTQFKVPFVCGCRDLGEALRRIKEGAAMIRTKGEAGTGDVSEAVKHMRTVNEQIMSLKGLGEKELGRVARDWEVDLELLKETARLGRLPVVNFAAGGIATPADAALMMQMGCDGVFVGSGIFKSGDAEKRAKAIVQATTHFKDPKVLVEVSKGLGEAMVGISVTTMQDRDKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5P4</accession>
    <name>A0A6A7C5P4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_242218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="2">Clathrin-coated vesicle membrane</location>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="18265" checksum="111915EA8660D4B3" modified="2020-06-17" version="1">MAIKYLVLLSRQGKVRLAKWFTTLSPKDKAKIIKDVSQLVLARRTRMCNFLEYKDTKVVYRRYASLFFIAAIDPTDNELIALEIMHRYVEQMDRFFGNVCELDIIFNFQKAYFILDELLLAGELQESSKKNVLRVISQQDSLEDMEVEEDAITRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C5Q8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="353" mass="38586" checksum="CFBC42F7181287BF" modified="2020-06-17" version="1">MAPPSSVSRKAPGKSAPSLSMTPPRSLETAVSTWPMEPQPQLSDSVALPTLERPGFWHTKTLTKPSAPTTMTQSTTHSKALPKIIIPAFPAGYPMTDELRTLKCTHCKRPVLHYYMKAHIGDCLNKKQEKQRKKKEARDARDATLKEPTTTTTTTTSSKKRRLDDSTAEGGGSKKKKSKKLEPAASKPTKPTKVKAPVDVEKQCGVELPNGGQCARSLTCKSHSMGAKRSVPGRSAPYDKLLMEYQRKNQAKLTKAAIDANAPDPEEERERDRGPVDEDQETETIMNILASRWGGRPVYVHQPIRAGQRAQHNRIRAMLAGANIFSAGSRGLPFGTVPVGNRLEGRKNLAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C603</accession>
    <name>A0A6A7C603_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_212171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Leo1"/>
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        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04004">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42768" checksum="7F17E9F77E223CEB" modified="2020-06-17" version="1">MDLKMGRQPLPEPSDGEMYLMKVPAFMSIEPTSWDHRRFQPPVPDQSSKADSLIFSAYNTALSTIRWRRAPSNPSQLQSNARILRWSDGSLTLQLASQPTLQYEISGNALAPPLRNPAKPTPTSVSAPADKSGRAGDGTVPDEKYNESKDAFSYLIVPSEDTATLRVSHKLTAGLTVQQSGGINGVAVKKLQAQISHEAKSSRVKGGTGVGLKLIEEDPERKKQEAEKALKEKQKQERKRENAMMRDQERNSRALGRHGLSSGRGSGLNASFLEDEDGETGYTRSRKPGSARKPRQRHGSIYSDDEDFGRRNYRSREDEYDQEDDFVAPSDEEEEAPADDDDPDDGIEEPSPKRSRSTKDAEDEVEASVAPVRKRQRVIVDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C629</accession>
    <name>A0A6A7C629_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Lytic polysaccharide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_212580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2342176at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025656142" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="210" mass="23285" checksum="584A4D577F8ED0A9" modified="2020-06-17" version="1" fragment="single">MPVFYSLLFLCSSAWGNMEMSWPYPFQSRLNAANGKSQVDFSTQAPLKHDGSDFPCKHYHQAQPLTPSATYAAGSTYNITLVGNDPLGGGSCQIALSNDNGATFRVIKSIIGGCPLDRSYKFTVPSYTPAGDMLLAWTWQNLRGEQDFYMNCAPVRITTERSSPKQRRTASSQFNNLPYIWKANIQGHNQCKTKAGVEVVYPHPGPDVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6G3</accession>
    <name>A0A6A7C6G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_255219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2863091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21855" checksum="75AD58A293397717" modified="2020-06-17" version="1">MLVSSILKLFYWLGSRFDTPLLLQAILMCIVQVILLHVALANRTSVLPTLPSSSLRPRTSSRPYSFWRWTAQRPYWNFLGSYTAALAVLQFLMGNHSTAYTSLQGLVALGIEAILPVPQILQNRRLRSCKGFRFSVLANWVVGDAFKLSYLFIKPVPWVFRFCAIFQAVCDALLGLQFAMYGDTPTITLEDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6I7</accession>
    <name>A0A6A7C6I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6I7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8489" checksum="419013E09E5BD4E5" modified="2020-06-17" version="1">MMLGRGSALLELSCCELGSIWAPGLDLCGACHRMWTLSQALVKPSCTRKRASRGTRKRPVTLNKFHLTVALRVSTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6N9</accession>
    <name>A0A6A7C6N9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_274897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6N9"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="573" mass="65824" checksum="38EDDC6BCF12B13E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6P3</accession>
    <name>A0A6A7C6P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_255582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6P3"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="103"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2862655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="42179" checksum="0EDFB20C26CD3F07" modified="2020-06-17" version="1">MPSTEGYISISPLLKTLSTSPRNDLSSEISAAISLILHNRVSPIQTALLLWSLHTTRLDHSPSVLNSCAASLLSACEHPDPGALSTTLLAKRPSLSRGGYKGGLVDIVGTGGDGHNTFNISTTSSICASAKLLVGKHGNNSSTSLSGSADLLARVVPRAPRLEAVRAETLARVYEGCNYAFLYAREWHVGLQHLAATRREVPVRTIFNLLGPLANPVQEYVEARVVGVAREEVGGDFAEAVRLSGARKALVVCGEEGLDEISCAGGTDCWFIDDGNGIERFNLHPRDFGLDTFPLTEVEGGKGPDENAELLMRILKGELDPNDPVLQFVLLNTAALLTISGLPEDDNTCKIKERGPGGLRWKEGARLARECIDSGEALRQFEKYIEVTNGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C798</accession>
    <name>A0A6A7C798_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_241640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C798"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17976" checksum="65DD583A9633FCC3" modified="2020-06-17" version="1">MASLSSRRLQRELVKLQTSTAPGITLANAENLDEWLVDLRIPDNPIYPSNEMFRLRLTFSPQYPIEPPEVVFLSLRDPERKVPIHPHIYSNGIICLDILDKEGWSPVQNVESICISIQSMLAGNTVAQRPEGDEEFTRTNRRRPRDVSFLFHDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7D0</accession>
    <name>A0A6A7C7D0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_280282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 8"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7D0"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="11">
        <location>
            <begin position="227"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="441" mass="50141" checksum="F44279E9660EC362" modified="2020-06-17" version="1">MQQPPKEGKAPEDYKFWNTQPVPKFKEPNLLQTTDGSNGAQSLPEGAILPDAVCKASIKPQPEKLVDGFEWCEVNLESSEEMQELYDLLYNHYVEDTDGSFRFNYSTRFLAWALKPPGGHSQWHIGVRTKPAVEGKKGKLVAFISGIPITLCVGTHTLKASEINFLCIHRKLRSKRLAPVLIKEITRRCYQLDIFQALYTAGTVLPTPVSTCRYYHRSLDWEHLYSMGFSHLPLGSTKTRQKYRYRVESHPQLKGLREMKPTDVSAVKDLLERYNKRFALRQEFTEDELTHLMCSAASKGVVWAYVVEQEGRITDFISYYLLESTVLRSQQKSAIRAAYLYYYASDAAFSDEAGANSSLQKRLQALVHDALILAKRDGFHVFNALTLLDNPLFLSEEKFEPGDGKLNYYLFNWRTAKLHGGTDENGNADESRQSGIGLVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7F6</accession>
    <name>A0A6A7C7F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_211043</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7F6"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025529630" description="ABC transporter domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="942"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="367"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2863333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116664" checksum="A1C32A4A5F22CA71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7S8</accession>
    <name>A0A6A7C7S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7S8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="182" mass="19131" checksum="25B29D86D5A7F218" modified="2020-06-17" version="1">MPPFNTSSGSKTTYSSLKYCTATVRPTYSSKSSADVDVNGIGAKTVDSLVLHHLHGERSGRTEGPKKERSNNSSKSSQSTQAGCIERSSHTAQSSQSPKSLRGTQSGHSTQSSRSIRTAQISMSSHSSNSSRNSTYSGGKVLVNSSARSTSSSGGGSVDNGAMRAKCAVEKVWDCGLREKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7Z9</accession>
    <name>A0A6A7C7Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Pheromone processing endoprotease KexB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_280296</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7Z9"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025693060" evidence="18">
        <location>
            <begin position="24"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="479"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="750"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2863372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="818" mass="90315" checksum="6627255E630CEF3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C868</accession>
    <name>A0A6A7C868_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_292450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863684.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006571">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="391" mass="44564" checksum="3F437B903F1A8A9D" modified="2020-06-17" version="1">MISAEGRQSNVSILFNGHYVSRSSDWIMYSVEARNIDKIVETYGPSTKLGAIVGGQTSTKAPEITAFEKHLPGDVEIISCHSLHGPGVDPKGQPLVIIPHRAPDKSLELVKNILSCMNSEIVQLSAAEHDRITADTQAVTHAAFLSMGTAWCANKQFPWEEPRYVGGIENVKMNITLRIYNNKWHVYAGLAILNPNARQQIRQYADSVTELFKLMLGGHRKELTDRIYTARDAVFGKTRKDQELLLEDEVLDRFSVGEKPKERLKNNHLSILAIVDCWWKLHIVPYDHIICSTPLFRLWLGITEYLYRNPSLLNEAIETALTDNTFRADDLEFTFAARDWSECVSLGHFEAYKEKFERIQRYFAPRFPEASQIGNRMIQTIEANLRSRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C876</accession>
    <name>A0A6A7C876_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_210536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C876"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00652">
        <property type="entry name" value="TBP_TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="183" mass="21132" checksum="1A97A2E557602725" modified="2020-06-17" version="1" fragment="single">LTPTRNIVSTANLDCHLDLRHVALNAINTEYSPKRSPGLTMRFRVPRVTGVYFSTGRLIIFGAKSLRENKLAARKFGRVIQKLGYYPRLKEMRIRNIVATFRMGRKIDCVALAKSEHWEKCFYEPERFPALEYGYGEVDERGKPEVTVRVFESGRVTIMGVGSEEKLVEVFEKMKILLEGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B6</accession>
    <name>A0A6A7C8B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_210682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8B6"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="20088" checksum="3DF8671F619D0425" modified="2020-06-17" version="1">MADLDTYGDETRNYEERDYGSHSRNRSRSPDGDHSRQRDEPPSHRDDRLTASSGPPERPRESEDALNTGSNLFVTGIHPRLGEAEITRLFEKYGAVEKCNIMRDPHTRDSRGFGFVKMETAQEADAAKDALQGQVYEGRTLSIEKARRSRPRTPTPGKYYGPPKRGANWQHFGAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8K4</accession>
    <name>A0A6A7C8K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_261839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8K4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="19490" checksum="0FA228A0D2D3C673" modified="2020-06-17" version="1">MFPPMRICKGCWSHLVIAQATQNICNGMQSAKEIDILDFAIARTKVLHLRSCKQPPLDGTLQGIGIAHDVRETTLEPKFSNSTLQLELWVRDTFTEKLWALQSLHRKLKTHAQVLRQVAGQGNAKEDKGGRRKKKPMVENIFPTTDPSLLKIGTVKATLPESVTFYKVECHASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8L9</accession>
    <name>A0A6A7C8L9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_125444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8L9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="175" mass="19489" checksum="EB0F91F6763C058E" modified="2020-06-17" version="1">MLYLASHRGSWSLCVADGFWGPWVAERRQRIREASWLSCLAVAISFDCTIEWRLLLPSLSAPCKPRPRIACVSLQGSLRYPPRPALECFSCRSRTQQNDRIISNRAGSGVRFRSGTGLRPPKLARACLRLPAAPTRRCQSQYCSLAWHHVAKQPTSNPPSPESFVATAEALARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8N3</accession>
    <name>A0A6A7C8N3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_82744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="76" mass="8671" checksum="D5BDCE1814A16774" modified="2020-06-17" version="1">MQYSLQPDWEDLLPSVPQQRRRSQNHPKSPLSLFPIPPQPIKPLPNLFTYPNKARSSQPNLHLSHSPPPPPPTTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8Y1</accession>
    <name>A0A6A7C8Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_139340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8Y1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12891" checksum="A1454F432817BD3D" modified="2020-06-17" version="1">MGHVYVHAGWGAHRLETWAIPARRPISYGVKVLHPHTPIEERVAEGFFPCTQPSDEEYTDSEEEAQFDPAMDAKSTNYEVSSEGGQAFDGKTDKLPAFLMHMRLKELLDSDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9A1</accession>
    <name>A0A6A7C9A1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_209419</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9A1"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2864084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="596" mass="67315" checksum="6971F347A5DAF0A0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9P7</accession>
    <name>A0A6A7C9P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-CHY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9P7"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="258"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="658" mass="73287" checksum="266E645D25323804" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA84</accession>
    <name>A0A6A7CA84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_208435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA84"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="302" mass="34092" checksum="C1B8F49F59AC058E" modified="2020-06-17" version="1">MTHEELQYLDLIRTILTDGEKRPDRTGTGTRSIPFPPQHRYRLSADDGTLILPLLTTKRVFLRAVVAELLWFVSGDTSAKTLQDQDVKIWDGNASRAYLDSVGLTDREEGDLGPVYGFQWRHFGAEYSSCHEDYTGKGVDQLKEVIHKLKTNPYDRRIILTAWNPADLPKMALPPCHMFAQFYVSFPEGGKGKGVLHSLLYQRSCDMGLGVPFNIASYALLTHMIARVCDLTPGTFTHTMGDAHVYLDHEDALREQIKREPRPFPTLELKKPAGSDVDGWLPTDFVVKDYDPHKGLAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAP6</accession>
    <name>A0A6A7CAP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_254134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAP6"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="318"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="540" mass="59070" checksum="7D9E9B5A77536344" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBJ5</accession>
    <name>A0A6A7CBJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_297501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBJ5"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="98"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
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            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="460" mass="50491" checksum="B43A62B4881D96E8" modified="2020-06-17" version="1">MAPGARIGVFQRKQSGPDGQHNNYDNAAGSSVHHTRGINAAGESGRSGFNPVAFARICWHSSCSASKWTNVLWPFALAAMILHFAHFSDEFQHDKRRLWVFITSYIGMVPAANLVGFAGQQLAHKLPKVLGVILETTFGSVVEIILFMVLIRGGNRNVPVIRAAILGSILANLLFCLGTCFFVGGIFHPQQTFHEAISEVGSNLMLVAAVGLVIPTIFYNSLAGGRLTQEKAERQALNMSHATAVVLLCAFLVYVWFQSQSHHGLYEDILEADEARDIDRQRDERKPKLTLTESLVAMVLALTIVSFMAVFMVKQIDYLVEELHISDAFMGLILIPVVEKASEHLTAVDEAYDNQMNFALSHVLGSSIQTALLNTPLVVLVGWGLGHDMSLNFELFDSVMLILAIVVVGNFLRDEKSDYLEGVLCVFVYILVAISAWYYPNPLHEGGTMVGYVTPSAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBT9</accession>
    <name>A0A6A7CBT9_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="31927" checksum="DAF1A760BEB6E42B" modified="2020-06-17" version="1">MAPTNFYGNLCTSTITYDYLWRLTSIHEHLPCHPQEIHDDSHKKIYRDINAFIDEYIHGYWRTLTSTSHKPLRHLPSKLKGNACAHVKALEHFCTPTSIYNNFCIGTNSHITEYIDDDYNRDIHEDICEQIQAHIITYEHQWAPATIYEYIHLRHTDAHFTPLQTKISHQRLERHCNYQQHGSYEDNYGDILLKTLTKTLADKYRIVDTYEFTFQDIDEAICGLTEKPRRLMTRFTKTYIALQRHLQIIHNSSRKTITNNRHHHLQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCL3</accession>
    <name>A0A6A7CCL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_6566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCL3"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2864575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="349" mass="39820" checksum="0892541B72CEFD80" modified="2020-06-17" version="1">MSSPEWLEIGRPSIDRPFGIHLWPIFSRAFGLVTGKKAEAFQFVQGETPMSTMKETAIALIAYYLIIFGGREIMKDRQALKLNGFFKIHNFYLTAISGILLALFVEQLVPTLARHGLFFAVCEYEGGWTQPLVVLYYLNYLTKYLELLDTVFLFLKKKPLTFLHTYHHGATALLCYTQLLGHTAVSWVPIVLNLTVHVVMYWYYFQAARGIRIWWKKYITVLQITQFVIDLGFVYFCSYSYFTATRFTWLPTAGVCAGEEFAAFAGMGILTSYLFLFIGFYISTYKKPVRKGRARATSALVEMKDEPLPDVKQIQRRLSGGQSTMRATTTGINTQGNAPNVRVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPL0</accession>
    <name>A0A6A7BPL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal protein S5 domain 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_273415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006053">
        <property type="protein sequence ID" value="KAF2857281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPL0"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="46"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31244" checksum="66C606761F0818B4" modified="2020-06-17" version="1">MPREQSPSTNERSFVRKALRDNARLDGRRLSEYRAISLLFPSPDAAEVRLGKTRVLCSVSCEIVTPPQNRKFDGIFTIVAELGPGTSPAFDTGGSRQELLLARTLEKTVRRSGALDTESLCIIAGEKCFHVRADVHVMDHDGNLIDASCLAVVAALSRFRRPNVEVRGGVATVYSAREREPVKLALHHRPFCVTTSYYEGISFQDANLLEEHCRDGEVIVSLNKFGEVCGIAKYGGVAVDALIMLQMIKDSLERVKALDMLVADALKESEERPIAELSAENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPQ3</accession>
    <name>A0A6A7BPQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Patatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_283937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2857162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="180"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="557" mass="61405" checksum="EBACF94875FB192D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006055">
        <property type="protein sequence ID" value="KAF2857252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="77" mass="8962" checksum="24989D3DB3E76C6C" modified="2020-06-17" version="1">MYMGHSLRVRRFVILVILRFTILFSLKSVVLLTITKYIQTVLQSVLPRIASLEIGYSRAIWHKNPVRYNKVPLCPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQL7</accession>
    <name>A0A6A7BQL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_273502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF3768"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12599">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25615" checksum="CDB20768F059831A" modified="2020-06-17" version="1">MIENAAETRVETIARLNDRCRQGLDRTARITVTRTCLATLSTDTLASEAVAQARLLQELRRHSFAADCPERDRGSFIIDDTEVFFRIDYYDPALEWGSLMPRFRPSAADIAAIRDAARREAKFERVGQVMLEVGRRQSLVSGETSINFALISDDPDWQDTDLDDYEPWTAFTRGVELTPDGRGLLDFYIRRRGDRHLELHGNISVAIAGGKLTTISGYPDIYRGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR72</accession>
    <name>A0A6A7BR72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_222793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="8689" checksum="C6761D45F66D1EE0" modified="2020-06-17" version="1" fragment="single">KFIQRSRVLSLYREILRTVRRLPPSDRSELCAFARREIERHSDVEDLEHIRYLLATGRRQFDEMRGYVHMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRA1</accession>
    <name>A0A6A7BRA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_279055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRA1"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="30240" checksum="5C60FC5901FCBB51" modified="2020-06-17" version="1">MNHFPEAWGRPRNDVYGAYNWAHLHGQQQPQTHTQTPIVTGTSVVAIKYKDGTVIAADNLASYGALARFTNVHRLKRFNRKTVVGFGGDVSDMQHIDRLLQELNVEENYYGNGESQDDDRALMSAKNVHKYLSKVMYKRRSDFNPLWNAILVAGLDEQDKPFLAYVDLLGTTFSGPSLATGFGAHLAQPILRHLVPDEQSTMSLSKEQAVEAVKECMKVLFYRDARSMNEYSIAVIDKQGVELKNKVPLENQSWDFADRIRGYGTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRE3</accession>
    <name>A0A6A7BRE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_177712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006049">
        <property type="protein sequence ID" value="KAF2857335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRE3"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="20676" checksum="CFDB52ADC07B50B7" modified="2020-06-17" version="1">MALLIQQVLRHRPDCHHNRFHRSRPAQDAPLAGHDQHRSQMIPRVSVSANNPKINAGPALIFATTILSMLTEVCPGTLAIIVGDITYGACCVDNDTARDLGCNLLMHYAHSCLIPVITATMALYVFVGIHIDTEHFVATLAHNVEPGHTIAMVGTIQFNSTLKGIASRLRAAEYSIIISKAVQRRDPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRF0</accession>
    <name>A0A6A7BRF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006032">
        <property type="protein sequence ID" value="KAF2857672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRF0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="134" mass="15114" checksum="909521C21606A5D1" modified="2020-06-17" version="1" fragment="single">IETRAKEDVEFGPQDGMPFHEDFGPFIDARVVQLNVNFWQNGVSAARGKRWNPLEVWTMNLAGFSRRVTQFHVSANYYVAVGAKMKVTSMLVGLMPDLVRPQRGVRAFDSRIFYLRDAPFPPSGSDYIPVAGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRU7</accession>
    <name>A0A6A7BRU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006044">
        <property type="protein sequence ID" value="KAF2857419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRU7"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="13">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="47585" checksum="B85E1D70BADC241E" modified="2020-06-17" version="1" fragment="single">MAEQQRISQLQESLKGANALIKRLSKLQFQEGSADADTERVELGEDIHESLKALEEEYDLLRQDIEDLKPPVPVDYSAKRRESDRQRKDLRLSIQCTRFGEELSHSRNRFRSAQLSAKRASDKAKSKERDAAFVALRSSTPNEQAAGDLFSTRRPKKEQKPLSKAEAEAQASTDVTAALRRTHALLSTELSRSRFAQETFEESSAALQQLGDTYTDLSSALDKSKDILSTLLRSQKSDTWYLETAFYILLATLCWLFFRRILYGPFFKLPLFLWRLTYLFIWWLFIKPFLLFLTLTGVLTKAGTTTSIAQSRAPLIVQPSASGGIPKINMEDRERIQRGGGVPVGGGGAGAKLGKDGSLLDKIGNMVGIKDNFPQQKEGENVVRRGDGTILQERGDIPKNPKKKTFETEAPVEQDERVKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS34</accession>
    <name>A0A6A7BS34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_273372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS34"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="364" mass="40539" checksum="D99C75C38178637B" modified="2020-06-17" version="1">MAASSSSARERDGSSRTRESDRGSRTRESGVSSPLWIPPPVVAGVASISLPTKREPTAADVEAQIQHLLDEQVECLTAPTATHDIRDIRTHICDAMATLVRIKETQITQLGRSREADAASLTYIDGFLAQRETLGEEERNLELESVQDEERMGKLHSHAANLQTQIDDMEEVLARLKADHAQAVDEIKCIRNALRTRNDTVQRQRQTLERNIHTYVQRQASASGKKLRSLEALRAATARSRDVSHGAREEAKFESDALQEGVKFWEQTVNSLQTFERAVASAINSGTNMDALFEDMIGELEERMETVKEKGWNLMICAIGAELEAVRTGRKLLPVSASLLDDPPSRLVRSRSNSTDDELVFSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BST5</accession>
    <name>A0A6A7BST5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_279057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
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    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
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        <property type="match status" value="7"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="541"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
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    <feature type="repeat" description="CHCR" evidence="7">
        <location>
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    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
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    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
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    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
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    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1641"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1668" mass="189208" checksum="C7894BD2476630F9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSZ7</accession>
    <name>A0A6A7BSZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="8" type="ORF">K470DRAFT_283340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSZ7"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="262" mass="29567" checksum="BE2C2F5036990C8A" modified="2020-06-17" version="1">MPIRRAARVCLFGAPGVGKGTQTERMLRKYPQLSSISSGDLLRENVRLRTPLGIQAERIMSTGGLVPDTVILRLIRNALTTRGWLVPTEEPRPFTLNSAAVGFDTVAADLFTMPPTDDTEHTYSEAPEASFILDGFPRTVCQAKKLAEMLPINMVFHIHTPPDIIIDRICNRWIHAPSGRVYNTTFNAPQVPGRDDITGEPLTQRDDDRPEVWKARLHSFEENVTPLLEYYDRLGVLWKVQGNCSDDITPKIFDEFSKRFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTE3</accession>
    <name>A0A6A7BTE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_283520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTE3"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2857985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="283" mass="30856" checksum="3D7EFE94D12BD37E" modified="2020-06-17" version="1">MLFEHFAMQDFSLYGFALGTKLPDVACKTTANYAANFEALTHTIRPNTDAKVVRTYSASECNSAAEILPGVREKGVRVVVWVWPDTDSIFSADKTALSEAIKRYEGQVYGITVGSEALYRGDPTGEILAQQMREVKDLFPNIKIGTADNWNKFTDGTADAVLQAGVADVTMANAFSYWQGKDIGSAVNTYIDDVQQALARVQELMGSLDVVEPTDGGSDYGPAKAGMANAASFFKKTVCALLGWGVNPWKPLSIGDSGIVQHEKQWRAMNADRTLRTNFSPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF9</accession>
    <name>A0A6A7BTF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_199906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="622" mass="69836" checksum="EE2EF5D5A0983D20" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTI3</accession>
    <name>A0A6A7BTI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_221076</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTI3"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Lipzen A."/>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR13218:SF8">
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    <dbReference type="PANTHER" id="PTHR13218">
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="40199" checksum="68D23DD9D0EC2FDD" modified="2020-06-17" version="1">MASPPPSTPTSIPSLALPRQRTGLSLPNAKAAAHVPRKPSITTASSFSHPLRQTSFPPSDASERQFSPAVGWLDEGGDDDLGSDIEVQSTISGPAGVEEVGVVGGKKKRKPGRPRGRPAKNAGTRPGSVVDDGGKAKAGQEEDGQDDDDEDDEVGETDAKGKRVPIYEGGQMTNEEMEEYKMRKNTFYLGARCDDHRERYTSYGQAKLNKNDLRRLVNQVLGQSVPGSVVMAMTSFTKAFAAQIIEDAKTVQLERLAVEPKRADGSENPAYNRLKRASERWEEAHADEPGTKKQKRSDEAGEEDAPIKDLSKDIEEQHCGPLLPDHLREALRRYKKRCGGPGGGTVGFTGLSLGGKQNTAPRTRGRRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU13</accession>
    <name>A0A6A7BU13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_260036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU13"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="339" mass="38152" checksum="7E4F7F7D5FB840C9" modified="2020-06-17" version="1">MNVDKIKVNGDPRVKYASTKVNGRTWCYLDAQPTSTPARGTIFLVHGWPDLSIAWRYQIPMLLDLKFRCIALDCTGYGRTGPSDNLSDYGFKAHADAIAGIAADIGAHQIILGGHDWGGAVVYRAAQWYPKLVSHVFSVCTPFMIAHEQYIDLESIVKGGLTNFGYQFQLGSEDHKVENVVNNEVMMRKFFKVVFGGRLSSGKPGLTPEHGLDLEALKSDEVSMTPLLSEEEFEFYVSEFLRNGLEGPCNWYRTRRLNFEQEKPLQNKDHVSQPTLFIQALQDNILTPELSKGMDERIPNLTRGEVPSSHWALWQTAAQTNNIINEWFQNVVLASKPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU30</accession>
    <name>A0A6A7BU30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_259445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="888"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1722"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1484"/>
            <end position="1515"/>
        </location>
    </feature>
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        <location>
            <position position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1847" mass="205408" checksum="39B4F91BF232D3CE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BU40_9PEZI</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2858856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="74" mass="8548" checksum="B92E50FDDFDACC2E" modified="2020-06-17" version="1">MAFLAVCIHSPRAWAITKCYSMKKANLKPNFFTTPGSMMFLAVLSAPRRRKKKNAKPQIADTELCWLSMLRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU64</accession>
    <name>A0A6A7BU64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_265782</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
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        </location>
    </feature>
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        <location>
            <begin position="35"/>
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        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="25546" checksum="828AE4ECE3BC21CE" modified="2020-06-17" version="1">MDPRNHMDVQTWLQTTVEPKPSDSYAKRPRHKTKPDRYEPRKRTKANDELNRKIKEEKAGKRLTLAPPVATGLFAHGRHGKREGVPDLATTEMKFLRDELRWSANPPPLQKKKSRDAMPHWDENDNRQKAMPMKQLPLTERAHRYRKRDVSPPAKKRRYDMKPALPPLEKSPCRHEQRPLDLSHFGYRGEEARDDDQSSCSSMTSALMRRAAEALVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BU99_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU99"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASL1"/>
    </dbReference>
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        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="267" mass="28803" checksum="63478C8151A55079" modified="2020-06-17" version="1">MSSSAVPTDYHGADRGHYTAVPSQATATSSVAKSGKRGVAYNDVKLVDILSSSPHVSWAYNWASSCAGLSKNLNFIPTLWGTAEEFVSVWKENAQSAIDNGSKYLFSFNEPDNSAQANMSPGEAAAAYKQYMMPFAGKGVKLCAPSITNAGGNMGLNWLTSFIEACDGCQIDCLNLHWYDSHDKTDYFKSHIQNATDIAGGKPVWVTEFGCTDGTPADISSFLQDVMPWMDKEDKVEGYAYFMASEGLLVSGSGPSEFGNTYVSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUC1</accession>
    <name>A0A6A7BUC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
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            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">K470DRAFT_236591</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
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        <property type="entry name" value="MGS_CPS_I_III"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
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        <property type="entry name" value="ATP-grasp"/>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
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        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="CPSase_dom"/>
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        <property type="entry name" value="CPSase_lsu"/>
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        <property type="entry name" value="CPSase_lsu_oligo"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CPSASE"/>
    </dbReference>
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        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Methylglyoxal synthase-like"/>
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    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
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    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="755"/>
            <end position="946"/>
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        <location>
            <begin position="1014"/>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858305.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128030" checksum="01AFB54EA357C9FD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUQ6</accession>
    <name>A0A6A7BUQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_259236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
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        <location>
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            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="43464" checksum="2F664BA866464A45" modified="2020-06-17" version="1">MNRLKPLIRQQRFGTLPRRNQIPKSDAEFRYRSVRFVRPPFFTRRRIVALAISGLAVYAYARVLQRYFTISVEIEFADDEEGEGEEGEEKEEYEEEGDEFADEESFFVPLTFPRKLDRVFYKGSDPEWQAFVALTRDRRRYKQMQEDLVHMVFNGCLDNPVLRRHLGDAAQVGKYWLDISFPDGPPQEYVRSGLEFGDGYVAWSQQRISPEQLWRTQRTLWPMATLKGIWATTSVVAGIQYRRALAALGLNSPPDPSAPEEQFRLATALAKKSSAVPVQSPAETSKKLPWLPSLPPTTASDLPIAWHVLNHSMAKSRQMPRMEPPRGTVVVQGLVELRGKRGHVLIDVRGFYDPKVSKYLAVRAQARAAKLWKQSPKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUS2</accession>
    <name>A0A6A7BUS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_114388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="20232" checksum="3C338DB3CD4BD7B9" modified="2020-06-17" version="1">MQAWCRKLYPHYSLSSIVWNLDSKRLTTRGVIDSWRLGKGFICPTPGWEAGASEKEDSVQLCCDRMAVKTAYLAEQTTAWTTPPNKNSEEVGNKKIPVAVMIPYRVRNRVGAENILRLRNWRIDRASRNWSQTNIQWIPERSKREKMIRLCLEFCPFGDVEDVIFHSGNSYQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUU0</accession>
    <name>A0A6A7BUU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_259403</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="MU006001">
        <property type="protein sequence ID" value="KAF2858903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUU0"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="144"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="351" mass="38732" checksum="4465EBF6795C3679" modified="2020-06-17" version="1">MKLRVRGPQGTSTIEIEDTSTWHDLLQQIRESTGVKTDFDLKYGYPPQALNTESIGGGVQLRDLKEDLNGEQLTVEPRSIQASLSKPLPPDAGIAIPTKPLPSTGMAVPRRHVAGDFPGEQGKPLQSSSVEPPVVPMPAMQGVLTLRIMPDDNSCLFRSVSSAVYGNSLDGMTELRGIVTQAIKDDPELYSAAILGKHPAEYCRHISREDSWGGYIELLALSKHFDMEFVSIDVQRLRVDKYNEGKPKRCLFVWSGIHYDVIALAEHEGANPEDDRKVFDVIHLDNDEEEDGGVLEAALWLCKELQSRHYYTDTAGFSVKCNTCDEEGIGEGWARKHARETGHADFGEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVL7</accession>
    <name>A0A6A7BVL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_220024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2859017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVL7"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="733"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="927" mass="104151" checksum="E86BB8AC4242374F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVP6</accession>
    <name>A0A6A7BVP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_219680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71742" checksum="59A6FAB8682A2429" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BVS8_9PEZI</name>
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            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33883" checksum="17F9A170A27B02BF" modified="2020-06-17" version="1">MPFTVIEWSGCQELPLPAGPFLVASRRTTVRRTTTAFDGCCQQIAETHNGAASILGFLMPSRERTYKDHELSDFLEGRERFTTMPRRSCSWRIKQKTSVLMYGHPRLTASDVRGSPVNIRSFSVGGRGPSFTMLRAGQSVARELPKLRWLKGVGQPARWVASDYTLKRRSWDLSLIWAMRRRIYYDSSGRRVRWESEIVRVINPEPATEEKLAQCDDIKVWLRLKTQSVQASRYPASLDWIPPTSNTCERLFSKACCVLIDYRKSMSNETFGAIMFLHGNRAWWEASCHSSCTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVY4</accession>
    <name>A0A6A7BVY4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_219645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
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        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
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        <property type="entry name" value="CHECKPOINT PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cell_cycle_HUS1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="335" mass="36442" checksum="D037DC5E191FE4C4" modified="2020-06-17" version="1">MRFRAEIRNVHTFTRFTASLATLGHIAWVRFDSTDVRFTVIPEMGSQVWSVLAPDVIFDTYIISSAATNNMINLEVPMGPLQRALKSAHNALAANIRLTKKGGIPVLSVTITSSATGSLAGATDIQDGSQDVEDEARHEREIVITQDIPVRVLAPETVENLHQPRCRDSEVHIVLPNPMQLKSISERFTKLAVSSKKAGRSGFAGNSLAGPKLELSANMHGCLRLSLKTDSMKISSLWTGLENPELDATVIEGGQGSLADHPSTRMKALGDATGQSDQGWATVRVEGKDWGRVLSVGRLGGRVIACFCHEHALILYVFLDEGESVLTYYITSYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW67</accession>
    <name>A0A6A7BW67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_100339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BW67"/>
    <dbReference type="OrthoDB" id="3943769at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="267" mass="30507" checksum="738A0F5BE56309AA" modified="2020-06-17" version="1">MMPKSGKVINFPWHRPMDFKKAYSEAAWDIKEYHQMHFRDMAITREKNKPRLAAIDKGQSKCGPHANYSAKFVFLNKTSEANAKALGYNTVDEVIKAAQSGKLHFDTCKYIELCWKSKNDAGELYQAGFPAWDTLITRQQLRHRPILTTCAAECIIDFCPDLLHGDTLLRIVSEAGYDPKMLRDRYCLNGCMADVNMFTDRVVSALGISREPRSTADELWVCNNMDQFNQYCLFLNSKPWHFSALLPRRQNGASEIPAGKQVIEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWB3</accession>
    <name>A0A6A7BWB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_198934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2859005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWB3"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="327"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="491" mass="54170" checksum="0FC0169A6D474DCF" modified="2020-06-17" version="1" fragment="single">LRKRKLPSQQASETDASVASRKFRKTSGGRRTPFGQTDTPEDRRPWVNRFAPADLSELAVHKRKVQEVRQWLDIAYRNKRQKVLVLKGPAGSGKTTTVKLLAAEMGVNVLEWRDPVNTCQLVKEESFSEQFEDFLRRGATSPGLTLCNSAENCSGKPAEDLSGSPAEVQGRNLLLIEEFPDISSRTSNYLQSFRSAIQQYVSALPVQSSPTPLVMVISEVLLSGNTAASDSFTMHRLLGPELMHHPYINTIEFNPVAKTYIGKALELVISKEAQQSGRRKSLGQVVIKHLAEGGDIRSAVSSLELVCGRSDVFKTSKEVLALINHREASLGIFHAIGKVVHNKRTEASVAQPPSYLPQHRRPLASEIDIDSLIDGLGTDTTTFIAGLHENHVLSASSVLESENCSTALSDADFLTAERSNPWNRATVTVGETLRQEVLSFHVAVRGLLFNLPYPVKRIAPKGSAHFDPNRIFYPSSLQIWKKEEEISAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWJ9</accession>
    <name>A0A6A7BWJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_271469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWJ9"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="69" mass="7785" checksum="98940B6E18465F3E" modified="2020-06-17" version="1">MPSGNMFQQAQDATGYGKKDYVDKGLDSIERKLGQDPNKLRFFNEKATDKARQMFEKATGKKVPSKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXD1</accession>
    <name>A0A6A7BXD1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_300124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXD1"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
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            <begin position="375"/>
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        </location>
    </feature>
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        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="591" mass="65585" checksum="A622C23484841E9D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXR9</accession>
    <name>A0A6A7BXR9_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_258846</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXR9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="116" mass="13175" checksum="A38C6727067A37B6" modified="2020-06-17" version="1">MHAYVDIPNYFSLNQPHNIYIKKPNKHIKRPRKELEHLSKDSSHPPPANRLELHSNRKSGAASQLDQTPIQHRPLPGGKNNPHVFGAYVSFCSTRLPWRSSTEMFRGVRGVTALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY31</accession>
    <name>A0A6A7BY31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_99601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY31"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="100"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="571" mass="61720" checksum="9C782C3A687EFF8A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYG8</accession>
    <name>A0A6A7BYG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYG8"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="20962" checksum="2E462428D100635A" modified="2020-06-17" version="1">MSDLISSLKPYSACDISDALLKLSVPNSGFLADIVPLGPTNNVIYARVSTVQFVSKNVPQSEASNIPAGSHWTDLPDEGSVAVLSADRDGVSSALCGDILATRLCKRGIKGIVANGRVRDVSALTSLTAPVFSRGTSTVGAGMELKAWRVGDSLTIGGVKDKLQEVVKLLPGIKEADDKCLQGVREGMDVNQVFERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYM1</accession>
    <name>A0A6A7BYM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_271222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM1"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="314" mass="33661" checksum="D630B60447BA972E" modified="2020-06-17" version="1">MGGKAAAKASYFDKLKGLLEEYKSIFIVTVDNVSSQQMHEIRQALRGQGVVLMGKNTMVRRALKTFIADAPEYERLLPHVRGNVGFVFTNADLKETRTKLLSNRVAAPARAGAVAPGDVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITSDLKIVESGAKVGPSEATLLNMLNISPFTYGMGIAQIYDDGQTFSPTVLDVEESQLLKSLSSAISTIASISLAVNFPTLPSVMHSVVNAYKNAISVALELPEYEWEGISELKDRVQNPDKYASAAPVAAAGGAQAEAPKEEAKQEDEDEESEGDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ53</accession>
    <name>A0A6A7BZ53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_257762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ53"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0A1"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="205"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2860930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="662" mass="74218" checksum="470BFE02B31019E8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0C4</accession>
    <name>A0A6A7C0C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glutaredoxin Grx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_299550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0C4"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2860762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="11282" checksum="C7D06302ADFAE69B" modified="2020-06-17" version="1">MSPASKDKIQQIIDNHGVVVFSKSYCPYCQATKALLQESGANAHVIELDEIDDGSEMQNNLQEMTGQRTVPNIFIGRKHIGGNSDLQARKNELPQLLKSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0E4</accession>
    <name>A0A6A7C0E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_246723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0E4"/>
    <dbReference type="OrthoDB" id="5428081at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="82" mass="9141" checksum="634729D05B5295CE" modified="2020-06-17" version="1">MSGRPLLLTVCCAAITVTGAWYGAGLKIREEKAKEREEYAQTSVAEKIRKLEDFKAGLVRQRSEIEEKVARINEKVMDNVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0R1</accession>
    <name>A0A6A7C0R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0R1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="292" mass="32891" checksum="6AE763CD9E766CA4" modified="2020-06-17" version="1">MRHKTSSASLSSNSGSRRMSNPGFHPFGGRVSKHYIESSNGSHGYSPDDAYLSYYDVRLTRDDVDAIRGDWLTDNAIAFWQEYLERERLKAYPNANIVLLRPSMCYMLMCTEDPRSLKSALPDFSKASHIFLPVNDSRNPAIAEAGSHWSLLLVSVIDGCAFHYDSMTPANRQEAKLVTRKLSQLLGISFRFYDLTDTPQQENGMDCGMYVCLIMSHLLFMKLLAADKEGVVNMRLGGKDVDAAAGRREMLRRIESFRREGERRRSSSRSRSLLGSTKSRSPPRVGEENSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0U2</accession>
    <name>A0A6A7C0U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_43554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0U2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="8408" checksum="4FC7ABBBD5F50AC8" modified="2020-06-17" version="1">MCRSLALSISSPIFLGYQLRSRASDSPAKRLISAKRLLRWSEEMNRVLGYERVQDRAMECKNSSFNGRAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0U8</accession>
    <name>A0A6A7C0U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_216509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0U8"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2N9"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2861771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="649" mass="71130" checksum="DFF0D41AF345CAC0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q4</accession>
    <name>A0A6A7C2Q4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_215633</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q4"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025555234" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="286"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2861225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="763" mass="86968" checksum="27628AF3664FCEC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2X1</accession>
    <name>A0A6A7C2X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_269922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2X1"/>
    <dbReference type="OrthoDB" id="5355510at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="297" mass="33238" checksum="F85FDC9E7C6AAEC6" modified="2020-06-17" version="1">MALEAMPLGHGANMLIHPPRILYFASRPNGILVPLIPADEFPLGVQLQGVPRMVRLSHTIGMQYAGGLPTLGMPFDLEGMEHEWHLPPGMAPPLPTPQSSPIKRPSPVTTLLKPGLPPSGTQPDQNKKEYCTYWIRTGECDYMQQGCLYKHEMPDKATLDKIGFRSVPRWWREQEAESRSKMHPRPPPPPPSTLKSWRIPEDRIVILKKGERKASTVSDLIDLSVPVVIPPTPPSTSSESFPPISKPKPQDTTRNVFVPRGESPNHHVAEALTIRRRQANGQKPTSMPRKQKEKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Z0</accession>
    <name>A0A6A7C2Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_200649</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Z0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2861834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="32533" checksum="E21A42DD81AA2989" modified="2020-06-17" version="1" fragment="single">LPDATDWVSTPLRAVAEIEASLHCQICKEFFATPMTTSCAHTFCSKCIRTSLSADGKCPTCRAQDQASKLRHNWALEDVVDKFLNARPAMLAVARGKRARERYNNVDIEEMYADKGEGGRTRKSRRIAVKAEEQTEEHEENALVECPLGCGKRMQIALVDGHLDRCEDEQREAKMPPPPPPERLAELNYSLLKENALRRKLEELGIPSWGNKLLMTKRHVEWTNLWNANCDSTRPRSKKDLLKDLNGWERSQGGRAAGGTSAVARKDFDASGWAEKNKDEFVRLVAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C363</accession>
    <name>A0A6A7C363_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="21"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="49942" checksum="7CD130B388631945" modified="2020-06-17" version="1">MGKSGHNDTTVHERVAPAVTHETIERQQHEQVQTALDKEIHQDHYHTSVQPIVDKNVLPEQHHSRVAPVEHRSFEHDNPEKVQQALQAEQAKFRDTTEHVQGRSTTSAGPTLAGQHTHHHVHETIQPVVNKQTIEPHVVHTTVPVHEVHHNAAQHHATSALPAVSMSEFKQQGGVLHGREERQDGFQGEPRALSGATAGTTGTTGLHGTHGTHGTHTTHGTHGTHGAAGAGAAGAGATGLAGAAASHHNKKHTSGRRSSSSSSSSSDGKGGRVKRSAKNKLAGAATGAACSRGVHGSHTGTGVDPALAGTTGAGVGAAGVAAGTHGHHGTHGSHTGVGSGVPGTHGSHTGTGVTGSNTGYGSTSGVPGQTGTGVTGTAGSNTGYGTTGSNTGYGTTGSNTGYGTTGSNTGYGTTGTHGTGVTGSGVPGTHGSHTGTGATGSGLTGSGVTGTHGSHVGSGATGAGVGTAAGTGVGSTATHQKPSLLDKLNPLKDADGDGQKGFMK</sequence>
</entry>
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    <accession>A0A6A7C364</accession>
    <name>A0A6A7C364_9PEZI</name>
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        </recommendedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="123" mass="14476" checksum="D3E919EDD91ACD4E" modified="2020-06-17" version="1" fragment="single">NFAATAKKHLVNRTISYKRFQGLRVNRDAALKARRSLSQEQEKELIKYISFMCDWCLPPSPAIVLKLAQSICQQDLGKNWPGRFVERNRKNLDCRYLNDIDLLRHKAGSRESYRAYFEVLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3M1</accession>
    <name>A0A6A7C3M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="426" mass="42057" checksum="C52D531B9B8A619D" modified="2020-06-17" version="1">MDGSTISLVPGASAVVINGNTQSIGHATPGAAANIPLITLGQVTYTANAATQFSLGPGATLTPGGVVTIDGTTISLADEATAIVVDGKTQGLNPAAVTPMPCLTLGKTVYQPNAGSTFDVGGTIFAPGGVAVVSGTTISLSPDASYVVINGKTTQLGATATGHVIATITAPPILTVDGQVYGGNGGTTYVIGEQSLTPGGAVTMSGPNGVETVSLNKDANVLYSIVGSKTMTSPIGMIGAMSTGAPVLTIAGTTYEAAMYDLGAGPTYLVNGQTLTRGGAIAVSGQTVSLDGAGTAVITISSDHTITSTISGAYGIVPTAAPILSIGKRNFTAINNGATYVIDGKTLTPGDTETVTIDGKGYVISLEPEATLLDVSTIGGGSSKETLFPARVTGTTEVQGIAVKDAAVQISVVAAALASFIFAIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C3M4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="539" mass="59693" checksum="B6825D488F6D15BD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3X1</accession>
    <name>A0A6A7C3X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3X1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="25273" checksum="E37A50E344AA3C78" modified="2020-06-17" version="1">MAGNDEGSVMVPVEYEGMGTYAGLTMTRYVAIPQHIIDEQEEFVRIYGTLPYISPYARGDEGGRRRSYSEVPSLVEDAGDVESLFTETSSPLPRTASPETDRAASRSEDSPFVVKKGGTPTVVEVGEDISTRKISDDVLHLVAIINSLPLSRTAKYNGLPVRHALTHHPALYNEVSKRSGYLKVKESKLRPYYGDERLFSPRMWWFLDPRGKNPPPDRRRSKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C494</accession>
    <name>A0A6A7C494_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_255968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C494"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="243" mass="27936" checksum="7767E93B2E038050" modified="2020-06-17" version="1">MARNAEKAQSMLFRFRAQQASDLGILDVNKTRRPRAVTTIDSVPVCERWRGQIVKEISRKLNKIQDVSLSDYQIRDLNDELNKLFKEKWQWEARIRELGGPNYMRSHIDGVESGGKGYRYFGRAKELPGVKELFEAVARAPIEAEEERQERRRAGELRQEIRNRVDAGYYGCIDEEDDALLAAEAAKEKEAFSVMMDEPETSGPEWEPLPGDIGDGKAWKLPTAADVEAELLERRKKRLLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4M0</accession>
    <name>A0A6A7C4M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_269434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4M0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="201" mass="22273" checksum="9250C1CD5EFA60F6" modified="2020-06-17" version="1">MQRSALAYCVTVFGEARALSAAASSSRTETASIFPSLPGTGLRVKESSFWTVPLLPGPQFHRGPAGNCEEAQYEAIAKSQEALKERIDKTWAFVTPWRSTGKSLTHHNTNPPATQIIQEQQAASDAERRVENLNVKLEDKWAYDTSDDAHVISLYAKVNFIVRSTPKNYFVVAWLSEFSVVVIGTATILVNDVTFHLSDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4V2</accession>
    <name>A0A6A7C4V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_275319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4V2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="171" mass="18707" checksum="4ECAA25D8111FA3F" modified="2020-06-17" version="1">MLPKNKYSTKHSATKDGSKKRNAADQPDDTPPPRRPKVEPEDDAKDHGINPEEVQSADSSSSVSSQSTINKYIASDQPDGDIVPPILQASSKNVERDHEINPEVFQSVDNNSSFDSWSIYGRPVENPASVAITPMMTMDEGVAFLQQTNLMLPDYLDLFLSVDSAVVANAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C512</accession>
    <name>A0A6A7C512_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF663-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C512"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="814" mass="91685" checksum="5F1CFDA97D6F528B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C559</accession>
    <name>A0A6A7C559_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">POPLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_262751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="27394" checksum="A9012E2D0CD1A082" modified="2020-06-17" version="1">MTQTANTSTAPRVAKEIVSGATPNGKGRWGQWPTEVDIKKPVPMIKTSLICVMRSVVPVSISARLTQEMRDAEMKKAAYVKGGLGCTLKTARQVSGYPTIFGPWARRLTRTRNADDAQTNGDATLFLSRAFDSPMWHCKIFYPLGMGKWPLVGDSSEYGEIFFERSRLIFQQDFPSTPAGVELNVIRRAERQLTHQGQRKSRRENLNEEIGDPFGVPGISSSPLLLRSIGAIPRPDKKDYVKKNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C587</accession>
    <name>A0A6A7C587_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_212267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="504" mass="56145" checksum="32AA6C448B390127" modified="2020-06-17" version="1">MCGIFCAVCNHQPLWPSSQCLQLLQNRGPDYQSTRHVALNNNSHLTLVSTVLSLRGNETVSQPLRNDQRTLCWNGEAWSIDNSLVRENDTEVVFNLLKQVESPTHFAALMASISGPYAFIYHEGVNNLLYFGRDPLGRRSLMISRTSEGGAALCSISDPMLPDWKEVDADGIYCLSLGDASLEPHRIPYQHHPVSLNKSLSSGSFQLSPNSAPVICLEEILRSSLQPRVATPSVAPRLAILFSGGLDCTLIARICHDLVLSNEPIDLLNVAFENPYVKSRYETCPDRITGQASLEELKQVCLGRKWNFVAIDVPYSETLQHRPTIIQLMRPHNTEMDLSIACALYFASRGIGNVEDGKQYSTPARVLLSGLGADELFGGYQRHATAYRYHGTVGLLDELELDFSRLGKRNLGRDDRVLSHWGKEVRFPFLDEELVSWSLKEPVAHKCGFGEQESCGMLTPDKKVLRCLAWKLGMRKVASEKKRAIQFGARTAKMEGKVKGTQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5D2</accession>
    <name>A0A6A7C5D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_243992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5D2"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="16096" checksum="0170D49FBEBF6BDE" modified="2020-06-17" version="1" fragment="single">MPRQTAPPPSDEFDIHLTKPFSGHPKHTIEIIGEPNRPATVRVTHYNSETKFSEKTGEVPKDDVHELLELVSTMTGLPSNQSKDIYGHDTKVQFNTFKGQWSNADVDPSADSIHELAREQKDDFKRVSDSIEALSRTFAKHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5G1</accession>
    <name>A0A6A7C5G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_229598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5G1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9273" checksum="BE140BD60323CF27" modified="2020-06-17" version="1">MPPRPDLTGFDPQKLAASSGFTERDPWKRAEAWRYTGPFTRMNRFRGLFPGFGIASVAFAGYLVYEGLYMDDPHEHGKDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C636</accession>
    <name>A0A6A7C636_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C636"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025680428" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="97" mass="9956" checksum="3441A7C3803F2D65" modified="2020-06-17" version="1">MRTVIACVLMAGALGPAGAVYIPVTGSAQPCTPKIEPQIFGPLSSATCIDYKKTVTVTTSTTCPEITPVPLGHGPVVQCGTRKRTCAATTTTLTCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C642</accession>
    <name>A0A6A7C642_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_280565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C642"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12622" checksum="BEC471DA445FF699" modified="2020-06-17" version="1">MACCSNRVNVPKTRRTYCKGKDCKKHTQHKVTQYKAGKASTVAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTTCKTKSQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C661</accession>
    <name>A0A6A7C661_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C661"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="354" mass="41034" checksum="9BC5E8E56FB737F2" modified="2020-06-17" version="1">MSRAGQAGGGGRKISFNVSENYDIQDVVGEGAYGVVCSALHRPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRNYESFSEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRALKAMHTANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASTEDNQGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKIPWRAMFPKTSDLALDLLDKMLAFNPVKRITVEDALRHPYLEPYHDPDDEPSAEPIPEEFFDFDKNKDSLSKEQLRRLIYEEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C678</accession>
    <name>A0A6A7C678_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_275283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C678"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="234" mass="26310" checksum="2D5553106BA0ADBA" modified="2020-06-17" version="1">MSTPLLVGISGPSCSGKTTLARLLRDVVPETTVLHEDDFYKTDADIPLKDGVSDWDCLEAIDLPALANALKHVKEKGSLPSNLMSKEDKNTVGKVAIDQKKVDALKKRAAAEHSQRRVCIVDGFLLYSEEMKTVRDLLDIKLFLPLEFATVKSRRERRSGYMTLEGFWEDPPNYVENIVWPNYARDHAFLFKDGNVEGELDEAKLKRLDIGARSTDDMTASLEWAYEIVAKALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C681</accession>
    <name>A0A6A7C681_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C681"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="692"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119512" checksum="CA527EF9831AF60B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6K5</accession>
    <name>A0A6A7C6K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_298322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6K5"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="39"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="527" mass="57538" checksum="FDD76D201B4B4C6D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C716</accession>
    <name>A0A6A7C716_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_242436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C716"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="147" mass="17052" checksum="4E19DF22C6FB3EA9" modified="2020-06-17" version="1">MHDKPCVCIHVYHRDRLPVGKENHKKYGNGIYHWAIWVCPKSADALDQTTTFDATDGLRVTPEGKTINPDLSRWYRLRKHEDPTRNPKFLTAIYIGKLPKSITVDNVEKMLGTMPLPRKTHVPRESFVSWARNAILRLQKEGCVDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7F4</accession>
    <name>A0A6A7C7F4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7F4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="212" mass="23741" checksum="5A09CA9295DD036D" modified="2020-06-17" version="1">MPPTTLMVNKHTKLKKNQAFAPSPLRFSLPASPRTPTSKNLPETDKIAQYLTQTDIPLPEFKPLRTALQLPPPTASNIAKPSIDEEPSKQLFLEVLIPFNLIPGPANATLKGHIMYRGQLEGENFILAVSINTTEETITTSARIVKGEEVAGYIPLPQSRWAISLMRKGRFTWGISPTRGRLGVFFLRGICISFVFARTRFWRFWMVVVHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7L6</accession>
    <name>A0A6A7C7L6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_193613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7L6"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025584025" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="261" mass="29489" checksum="BD39B5562775A761" modified="2020-06-17" version="1" fragment="single">MVMNWLAVLQVPVLIFSYWNACSYLAKSASVLHGRNISLLIAHPDDEAMFFAPTLLSLTKPELKNQVSIYCLSSGNADGLGYVRQSELYQSALQLGVESGERVTIIDDVKFPDSMMGIWDPELISNELAKNLASINTIITFDERGISQHPNHISLFHGARRFIQQSQAPIQLYTLSSVNIVRKYSSILDSIWTLLHSTWRNFSARNNLKCGDLPAVLVTVSTPADVRRAQKAMTTAHRSQMRWFRWGWIGLSRYMVVNDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C858</accession>
    <name>A0A6A7C858_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_267788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C858"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="275" mass="30562" checksum="845ABD6099404185" modified="2020-06-17" version="1">MEQSKSTDSAQIHTSARSPTPPGVATPPPTADASGKTRAVGDTEQELRAQIRDLEAALKVAKTAAAHHKLQYNMLVQESAAAMERMAVEARMEQYENEMIHRAAAAAPVEFPEGMIPVQRDLYQQMCEEIRTLRRVCGSLERERDHRGRTIARQETEIASLTERVTLMRERIRDRGLKGRSRAGTEADRPFAALLQASEMVSRRMAGRRGHTRGIHSMSSLPSTPARVYRPFVPATAPARPRHDEASEDTVSNSDGESEAETDILEGSRVRQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8U1</accession>
    <name>A0A6A7C8U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_297972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8U1"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:clathrin-coated vesicle membrane"/>
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    <sequence length="930" mass="103760" checksum="65F62945CA58859A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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    </evidence>
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</entry>
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        </lineage>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="80"/>
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    </evidence>
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        <source>
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    <sequence length="402" mass="43271" checksum="782FD6B24A0F0A03" modified="2020-06-17" version="1">MAVHERGSRKDSMTETRRSSFLPPPFTGPGLQSHSSSSPSPPTPPVSSKLQRLWVKDKGLVWILLSQAFGVLMNGTTRALEENGKGMDPFQILLARMSLTLLLASGYMWYKNTPDFPLGKPEVRGLLMARGFGGFFGVFGMYYSLQYLPLAEATVITFLAPGLACWACSILIHEPFGRLEKFACLVSLLGVVLIARPSTIFAASNSGNSTVDDDATPSQRLKGTGVGLVGVLGAASAYTTIRWIGKRAHPLISVNYFAAWCTLISVIAQFTIPGVTFSLPADLRQWGLLVFLGVCGFAMQFLLAAALSYEKSSRATNIAYMQMIFAIAFDKIVFGHSPDLTSIAGSSLILGSALCVATMASTGKPDYKALDDASPEHHDQSRQGLMTADVELANVPEGPERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Y3</accession>
    <name>A0A6A7C9Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_197026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Y3"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="91" mass="10445" checksum="D68C21A624FC0FE4" modified="2020-06-17" version="1" fragment="single">DYSETEYWGWVILVVTWITFTVGMGSCLGIWSWAWDVGETPYAPPELEDDPTLPIVGYYPALMVLTGVVVWVWVTVAWVGMKYFRHAKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA96</accession>
    <name>A0A6A7CA96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_208525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA96"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="38"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2864434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="328" mass="38149" checksum="B2E30886E70009F4" modified="2020-06-17" version="1">MPSTHKKDKPWDTEDIDKWAEAPFTAESNAGGPFLESSTFATLFPKYREVYLKAAWPAITKALAKRGIDCTLDLVEGSMKVSTTRKTYDPAAILNARDLIKLLARSVPADQAIKVLEDGTYCDIIKIRGMVRNKDRFAKRRQRLLGPNMSTLKALELLTETYILVQGHTVSVMGSHRGLKEVRRVVEDCMANIHPVYHIKELMIKRELAKDPQLKNESWDRFLPHFKKRSMAKRRVPHVVTKKKTYTPFPPEREKSKLDLQMESGEYFLSKFEKERVEKERKEESTKEKIKEKKRKRQEAFVDPDEEPEKKTKKKKKKKKETVDEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA97</accession>
    <name>A0A6A7CA97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_208295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA97"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="159"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864451.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="28406" checksum="95966F6F2431E6D8" modified="2020-06-17" version="1">MSSTGIPSNMPAMVLPPGGMPEVGPNKTLIQIGFNYELNYPFVIGADLATNQIFTYLPRGVAYGLEIPDGDVQMKGLLPYDTRASLHYITTLAQAYIPTDRLTMLQQDLCKTTSKFYHHPNSTVRELMLMINCSISVNPGSSVAGAQSSNPAATASSPAGEGAPIGADSGKSMPIKGTSVGISVGAIAGAAVYAATMFYVARRYRQRRQRHGRADSMPEMSHTEGMGMYGAGAGQERGSRQSGSTNGRSVREQGISHPIQAGNSLGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAA5</accession>
    <name>A0A6A7CAA5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="347" mass="39029" checksum="5A33271637CEB1D3" modified="2020-06-17" version="1">MFAPAHKPTRGRQTVLARRISLDKRKQKRDASDESDSASNESRDEATRQPPSPDPRVHSVSITDPFYVAGVSREEWVVSAAAPSEKPQDKPVEEEFLDLNPPLLPPRLGIEHRGQAVLKRNHADKLMTILHICMLRQDWHRAFRAWALLLRLEIGGTGMDVREYGHWGIGAELLIRTNEKEGFRQAQEYYNRFITRYPHAIARKYLVSAVAFYPALFNMWISGAQRQFSVDEHELGHKLQTALEIAARMDEVMESPAYNKSLPLLKLRGMVGLWISDLYIATASGEGDEGGDAEDNLERSRTERAKVIEVFGKLKSAGGELSESVLDLIETGGNDNEDDESSGGMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAZ5</accession>
    <name>A0A6A7CAZ5_9PEZI</name>
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            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_261632</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:establishment of meiotic spindle localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="51"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="39"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="828" mass="91498" checksum="894F25CD39AD2B07" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBB9</accession>
    <name>A0A6A7CBB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="116" mass="12624" checksum="0ABB03E0EBA6D2BE" modified="2020-06-17" version="1">MFRRTRHRALDGRVARTWLAQGSALSILDNPWSTSSGSAHVGFSTPTANPLACYHHVCADCFAQIARATVGHTTIRPGWLAKSKNRDFRNPRQPTARTGSPPCLPALAAGTMRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBE1</accession>
    <name>A0A6A7CBE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2864369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="518" mass="57136" checksum="9519B7492339D434" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CBR5</accession>
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        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_254192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6129702at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0140278">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
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    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="456"/>
            <end position="467"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="511"/>
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    </feature>
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        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">K470DRAFT_208393</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
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    <dbReference type="GO" id="GO:0005789">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP98</accession>
    <name>A0A6A7BP98_9PEZI</name>
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        <submittedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="4">Belongs to the AAA ATPase family.</text>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="640" mass="70452" checksum="CDD112EB628D3FCF" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPR0</accession>
    <name>A0A6A7BPR0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">DNA/RNA polymerase</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6748" checksum="EDBA4D16085CCB6B" modified="2020-06-17" version="1" fragment="single">RLRTLSIPEDRAMTTYLADGLKNNWIRPASPSTSCNPLFVPKKDGSLRLCVDYRPLNAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPZ7</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
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    </reference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="300" mass="34346" checksum="3B2CCF8D69E43A7B" modified="2020-06-17" version="1">MVLIRVKKTVQNSSEVMEETSDSIPDRRRVSKPNVHFRETVEYEGEEQRTKLRSIEEDDREHGSYHSSCHRRDRIVGGVGHLHYSDRDKVHALDGHRGGRDDRHGTRREYHSSRHDRHADGAPSSPDDRHGARILVGEGMPARKAPLRPEEESAAYTYEIHIRVCQSCQFNDDCRIGRFLADELTSYLRIKNGVVYRREGHTRVPVDLDSGYSYCRKLMAARRRDSDSWDAEHKLKDGHKLAMVNSPKSTSALEADKDAPKAPPKPILKEKPKPNIIVHERPTQPAPETALKTRSDSERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ04</accession>
    <name>A0A6A7BQ04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_261015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006056">
        <property type="protein sequence ID" value="KAF2857242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="451" mass="49356" checksum="D10374BB08C78E2D" modified="2020-06-17" version="1">MNPSPTKTSSASSAKVATVEDYDEEAGATKPDTAVRAHVKKEKPIPHRPPVVTTRPVKTKPVEPEPRPVPLASNWPQQSHWQPAPAHVPAPHPAPLHTAPPAHTASIHTAPRPPHTAPFHPAPWGHLAPPVRPIYHPYPPPANYLHYPPQFYGHQQPYYPQYGGYPPYNYTLPSPHLSQPPHLMPQQMPMYQEPVYQTRPRPSAPPSPAAHTNPLATTAAPERPVYSTRLSRQASTQRGRSMPGHFPSSESDEDGVWDDAPVDEPPSPPSHTRPPLTARLATAPAITQLQLDAENGAQTRAGSSRSSRSRQSGSTAGSARTKATSVSSGLVDDRRASRLAHRPRTTYEDIVPRDQIAEVLAYQRSQGAPTGLDFTSEELTRRRKPVGGTSQTSERSRRSRRSVESRTMEVSAQGKTVHLRGADAHFDLGSGVLIMKPRRDSACEDDYEGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQB6</accession>
    <name>A0A6A7BQB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_238326</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="140" mass="14985" checksum="F6F91979A74A864B" modified="2020-06-17" version="1" fragment="single">MVSIIEPHPSVLTPRYLPSGRGGAGNQHYYTPNELTNGQTATGPASKISLTRRQSSPLEEKLPSSRGGAGNITRHSRREDDLASRELSSRERSRDASPYVLFGRGGAANVIAPKYEREREGRFGETGSVSSKGSRGSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQG2</accession>
    <name>A0A6A7BQG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_170377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="520" mass="56007" checksum="16E34098C6345CBD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQM8</accession>
    <name>A0A6A7BQM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_273160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQM8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="11225" checksum="13B3F89DE9B9FF2C" modified="2020-06-17" version="1">MYIHSIALATTMPAKCTIVDPTTAVSPTVAFPIIFLLILVIALAYQIFACLRDMGADKRERDLEAAEKAAAEAKAETLQKRRGSCPRRRGGKLLERTGFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRH2</accession>
    <name>A0A6A7BRH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ESC reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_158203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006027">
        <property type="protein sequence ID" value="KAF2857810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="262" mass="27716" checksum="BB617511C0127CA6" modified="2020-06-17" version="1">MPDTSRLDGKVALVTGSGRGIGASIATELASRGAKVVVNYANSSEAANGVVEQIKKAGGDAIALKADVGDVSQTAQLMDEAIKHYGKLDIVVSNSGVVSFGHLKDVTEEEFDRVFRINTRGQFFVAREAYKHLSVGGRIVLMGSICGQAKGVPKHTVYSGSKGAIETFVRCMAIDCGDKKITVNCVAPGGIKTDMYHAVCREYIPNGANLTDDQVDEYAATWSPMNRVGQPIDIARVVAFLASQDGEWVNGKVIGIDGAACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRK7</accession>
    <name>A0A6A7BRK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_152391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRK7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="172" mass="19012" checksum="B1D21A1BA691CC22" modified="2020-06-17" version="1">MATSTHQITVSVPCPSQSVSWRASIAAVYPAMTSPQLAAFTKALVTYVHQADVGHAELTDQLQYLVHEHDGVARYHARRDARPIACWQYHFVHLLLLPPPLLSPSFPSPSLPNATNPTIELFRQSSLFLKILVLASDLSLELQWYVVGRDSTIFNSVVQVAAERCAGDDLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRR1</accession>
    <name>A0A6A7BRR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_260522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRR1"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="143" mass="15974" checksum="59320600FE98677C" modified="2020-06-17" version="1" fragment="single">MVRRFGPPQGTSSETPESLYQHLRSYVRHSNHQANSFDAAGHASIEAAQNYLANRGWWCHDGTHMTQDGEKCIEALNQPRMRRLLSLPVEPAAPTHTVSIQLPPGGLSAHDGLFTKFGLGWSRKLAQCIYPLACTCQMQFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRU9</accession>
    <name>A0A6A7BRU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_222323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MU006022">
        <property type="protein sequence ID" value="KAF2857933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRU9"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="260" mass="28225" checksum="307A074E5F6141B4" modified="2020-06-17" version="1">MSSNKITVTLPQLAKMIDHSLLHPTMTDEEIKAGLAVAKRYDVATACVKPYAIPLAKKELQGSSVEICPVIGFPHGNSATEVKVYEAQQAAKAGGSEIDMVINIGKALGKDWDYVQEEIRAINEVVTSNGAILKVIFENDYLQDEHIEKLCKICTDLNVKFIKTSTGYGFVKQSNGMYNYKGATIPQLKLMRKTAGSDVEIKAAGGVRTLDDLLHVMTLGVTRIGASATKAIMEEAEAREIGKEPKEISFKPMQDGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRV5</accession>
    <name>A0A6A7BRV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_283716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006034">
        <property type="protein sequence ID" value="KAF2857637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRV5"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="145" mass="16336" checksum="34576D54C27F97DE" modified="2020-06-17" version="1">MSRPQPFSCLRCASKRQIRHASYLKRPKRPYTFTQLVTLSDGSTFLHRTTSPQPVYKSTKDTKNSALWNPSSQKLLNVEEDVAGRLKRFRQRFGRGFDAAALEQGEDTADAAQNAADQEESLMDLISGFAEPAQADKEKKEKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS44</accession>
    <name>A0A6A7BS44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_301082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006019">
        <property type="protein sequence ID" value="KAF2858051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS44"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="320" mass="35802" checksum="E192E7A13A5D2B9E" modified="2020-06-17" version="1">MQRPTYSIPPAQTPPLHHPVPQHVSTVPQFRSPPLPASQNSSYGYGQSPAGGQGFMSGAQYMNSFMNDPTTHMGLQMGQTAMRAGHEYMEQNLNRFVSVSALKPYFNVSNSYVLSKLMLVLFPWRHRRWSRSANHGSAGTSAYLPPREDVNAPDMYIPLMAVVTYILLSTLIAGLNGQFEPQLLGITFSNAALIIVLELLVVWLGKYFLSINSDSQFYDLIAYSGYKFVGVIVTIAFTPISHRLLAWVVFGYTYFANAFFLLRSLKYVLLPSDNTAGNPAAAGTMQTIDRSQRGRRTKFLFIYSYGVQLLFMWWLSASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS48</accession>
    <name>A0A6A7BS48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS48"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="25731" checksum="FFD54F040CBD6F80" modified="2020-06-17" version="1">MCNYTLTQYTCTHYGVVTVDDKLCAIAKKVNWKPQDCTAKEFEGMKREDRLCDRCKEEGLKPPLGSMESLFEGIGKGKAAQTREEESTGKKKSPSFGAVGHWFNWAVKGWGEEGQPEKRSGEIERLVDAKERHVKREMQRIVREGRSGKSREERGSTSDEGKGEEPERMYVGGELEEDWVCVKSNLECDDSDNEGRVDPWEEKYGIIGLRDNPWGMPRKVLWFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS53</accession>
    <name>A0A6A7BS53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006049">
        <property type="protein sequence ID" value="KAF2857338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS53"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000217">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="6">
        <location>
            <begin position="482"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="949"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1240" mass="136916" checksum="C14E3C1F3D531255" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT72</accession>
    <name>A0A6A7BT72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_300878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT72"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="284" mass="32468" checksum="07CA418179684B88" modified="2020-06-17" version="1">MSLKQLSTRFPRGTWDTHMHVIDPRFPLSFPQYSPKPHTLSDAEPFYNALGIHKKVIVQPSIYGFDNSCTLDALRRFGKSSRAIIQFDPERTSPQQLEEWNNLGVRGVRLNYRSINTEIKQDSLAAEIIKYANAVRHVGWILDLYLPMESIPLLEPLVADQKVNVCIAHFGHPSNQSLNAAQHPSDIPGFGSLMKMLKGGRTWIKLSAPYRLNADPRDPLMEQMCKSFVREFPERCLFATDWPHTRFESLDITPYLDALLDWIEQTDGEGLGRICVKNADELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT79</accession>
    <name>A0A6A7BT79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_260528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="16120at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:protein phosphatase type 2A complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="436" mass="48020" checksum="9E1B0D90CF1215E2" modified="2020-06-17" version="1">MAAEVRALHKPKAHLKLERLPGGKDFHFEKPLKKINDAEGLNFFLSSIAHRDLMIWILQLNRSMFPTRTANRGFVPSELTSPPKYSDAVTHVRALLNELSALIEQAPPSTRPRRFGNVAFQDWYKLAEEASVDLLRKHLPGLLGQYTDEETLIQELSCYLLGSFGSAQRLDYGTGHELSFIAFLASLWKLHVFEDGEERAIVVGNIQPYLELVRKLVMTYTLEPAGSHGVWGLDDHFFAPYIFGSAQFGPAIDPDSQTPTPTEGSIPSAPPASAVTDKKVVAEQKEDNMYFSAIQFIYDVKRGPFWEHSPVLYDISGISDGWAKINKGMLKMYAAEVLGKFPVVQHFPFGGIFKWRVEPHAAGTSDMSQQPKQPKSMDVPPGPINPLGPTTTAAPWAGTAAPWASANGAASISQMQASTGVPSARVPGNLGTRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT90</accession>
    <name>A0A6A7BT90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_136026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT90"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="50" mass="5739" checksum="48F0E062416084F0" modified="2020-06-17" version="1">MTRRLITPSHGTSSHSDTPKSKVHPHPHSNSLQQQRRKFVKEAKHAETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTI7</accession>
    <name>A0A6A7BTI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_278671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006014">
        <property type="protein sequence ID" value="KAF2858257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTI7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="242" mass="27074" checksum="8462419CC0375634" modified="2020-06-17" version="1">MTPKLYVVEISSDDSYDMDDPIDKGNNDKELRKEQSGSSTEEGDLSDKKYLIEEDPLTPSQRVTSSGNVQPLTKTRRSPSTSSLSAGQQDSPLSPAAIRNKAKEPLADTNEASGSGSDSDSNSGDPSLGHYFDEILIRMMRKSHLSSEQDLRFLRSMFPWDPTPRYMPPALDTMKELYESKGEPYKPENLEKLHETSRNYLALRKCLVLILSQYGNLLMGSTFLEKLLTIADEARKREEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTL9</accession>
    <name>A0A6A7BTL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_222523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTL9"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="104" mass="11924" checksum="81EE14B56307FFC9" modified="2020-06-17" version="1">MLFFSFFKTLVNHQVTVELKNDILLRGTLKSVDQYLNIKLDNIEVLDEFKHPHLSSVKNIFIRGSVVRYMHLPASAVDIPLLEDATRRESTQTKAKAKPQTQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU56</accession>
    <name>A0A6A7BU56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_129835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006008">
        <property type="protein sequence ID" value="KAF2858507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU56"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31025" checksum="2D79539222B0B4A8" modified="2020-06-17" version="1">MFFPRPRSVRIQFMSDLHLEQVGYKFALGDPAASILLLVGDIGRLSDYAGYRCFMLQCCAAYDKVLLVAGNSEFYGTSHDQGLQLLHQLTQDPAVQGKLQLLNRSRYDVPGSEVTILGCTLYSHIRNDLGLTKNFRHIDQWTVEQHNAKHKADLDWLLREVSRLGSEKRVVVATYYAPLQKKVSHPAHEGNEYSQCFVSNALDIVRRVGQSCTITHWIFGRTHWNVRFKYLDIIVQSNQVHTESGRLTRWQKIFLYRPFDPRATIKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU80</accession>
    <name>A0A6A7BU80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_135659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU80"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="11147" checksum="9C2A8724A08FF024" modified="2020-06-17" version="1">MSVSLTSGKVQWSSSSAGPPTRIKSKRAYTRLWKRPGPPCGLPNSQSFKATVPERWSNEHNCWSIQGLGIFKKEGSPCGLGTTQVIILGCTIFKRPQGGRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU86</accession>
    <name>A0A6A7BU86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_259516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU86"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="162" mass="18148" checksum="5890694F31EA5696" modified="2020-06-17" version="1">MWGLLSSGKMHSHDKMSGMDDMCSMNMSFTWSFKNLCIIFPNWRITSTFSLIVSLIVIVFLTAGYEGVRKVARTCDCGPPAHGTTERSALLPPNTHHQARSLQKSRIVKAALYAIQVAYSFFIMLLFMTYNGWIMLAVTVGAFFGYMIFSADEPVEKSVACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH2</accession>
    <name>A0A6A7BUH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_112391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2858986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUH2"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="476" mass="53335" checksum="3E3FFF03AC435CAB" modified="2020-06-17" version="1">MVLGHRKSTSVEESDVGEDETVVGKEEGSVLSHIISQLRPGADLSRVTLPTFILEPRSMLERITNFMAHPELMLTLPLVEDPLKRFVAVTQFYLCGWHIKPPGVKKPLNPILGEIFTGYWDYADGTHGYYISEQTSHHPPKSSYFFMVPSHHIRIDGTLKPRSKFLGNSVGSFMEGIAIMRFLNRKERYFVTQPNMYARGILFGKMKYELGDQAIVRCPETGYEADIEFKTKGWVGGAYNAIGGYIRQSSTGRKLYELSGHWHGAMYIQDLSTGKKELLFDATNAKPSMVKARPLEEQGPRESQKLWNITTNAIKKADQKTATEDKTRIEDEQRREAAERGEGSWRPKLFKPAPAGDEESLDWIINADVDDKTPPEKQIEQILAIAPIMPGQTYQSQQPQQSQLPGQSNGQIPPPVQPAQPAQPALQPQQRVGPVALQSQQTPQPLSQQYQPHTVGGPIKRTDSLGNEETFIDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUP1</accession>
    <name>A0A6A7BUP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_259592</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUP1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="51"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2858687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="481" mass="53766" checksum="0FCC26FD042CFF60" modified="2020-06-17" version="1">MLRAKTLPRGRSPTTPHRTEATETKDPHRNTAIMSQADANAAAAEVEVFGKEHVNIIFLGHVDAGKSTLGGSILYATGRIDDRTLDKYKRESKEMGRESWFLSWALDETKEERAKGKTVEVGRGFFETDTRRYSILDAPGHKNYVPNMMSSASQADVGVLVISARKGEYETGFEKGGQTREHAMLAKTQGVNKLVVVVNKMDDPTVDWSEERYNECISKVSTFLRNIGYNPKTDLYFMPIAAQQTIGINKRVPKDLAPWNESPSLLEYLDNMPTPQRNIDAPLMMPISAKYREQGTMIEGKIEAGVLKKSGKYLMMPSRANIDISALYGETEDEVEQVMAGEQARARIKGAEEEDILPGFVLCAPERPVHCVSAFEAQIRLLELRSVLSIGFPCVLHVHASTEEVIFEELLHYLEPKTNRKSKKAPRFAKQNQNIIARIKVTGAAGAVCVERFEDYPQLGRFTLRDQGQTIAIGKITKLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV54</accession>
    <name>A0A6A7BV54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_220909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006006">
        <property type="protein sequence ID" value="KAF2858609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BV54"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="633" mass="70747" checksum="B57BD8F1F7E0358B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVI3</accession>
    <name>A0A6A7BVI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_272209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVI3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="11972" checksum="98A50D236EA7D15A" modified="2020-06-17" version="1">MQLLISNQPNTKRKREIDGEDLLEETTNWEDRDREKARKNAETATTKRLRKEARDEALLQNEMETAMVPSFAITQGLPQDDLEFGQADSMIQPSGSDPFLFDSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVJ3</accession>
    <name>A0A6A7BVJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_259538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVJ3"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="102"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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    <sequence length="426" mass="47410" checksum="87239FD7EABA8C20" modified="2020-06-17" version="1">MAESDISRLSKKVVRYFWDPPARNEDDAEIWCLGRHYDSRFHARRAANCRAVLVSTAHSQSDSSQAESGAVIVNNDHPEQSAENGKADLTTAEEEALGWPLDFLDDLEARIWLTYRNGFPLIPRSADSGNMSFAMKMRMMGNQNGYTSDTGWGCMIRSGQSLLANTLTLLQLGREWRLGQNEEEHKKIMALFADNPEAPFSIHKFVDHGAQFCGKPAGEWFGPSATARSLQALTSKYDAAKLRVYSRPDDGDVYADSILATAAQKSADDEFQPTLIVLGVRLGIDRVTPVYHAALKAALEMPQSVGIAGGRPSSSHYFIGHQGDNFLYLDPHYTRAQLPLDPTAADIASCHTRRVRKLHITEMDPSMLLGFLIRSTEDFQDWCKALVGVPGTPIIHVHEDEPKYANGRERPEAVDEVETWDEGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVJ7</accession>
    <name>A0A6A7BVJ7_9PEZI</name>
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        <recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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    </evidence>
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        </source>
    </evidence>
    <sequence length="448" mass="48243" checksum="0E50BEDE2785A428" modified="2020-06-17" version="1">MALFLVLSLVVALASVASSSSAVFVFDDLPAIQPFVFALTVDEAKKDLYIHMAGPASNSWMGVGIGEKMAHSFFFVAYTGSGGTSMILSPRVATGQSEPFHYKQVSCELVSANDLQGNNSVSLGLGADGIMSVDAVCHDATSWTVGGKRQTLDLTNSAQPFIFALGPGYSMHGGNFIQSDSLSANLRRHYIHGHFTMDMKQATVSEDAQVPRPNGPDNTSYITSGATSTGSKLQIDPAPIIHGFVMCVSFVVIFPLGAFALRFLNSVRSHMAVQVLGLVMVCMALAGGSVVSVQYNKSKHFRSPHQVIGILVLIALFAQLGLGIIHHRIYKKQHRGTPMGRIHHFLGPSVIAIGIINVPVGFMFAGNARLSLPFFFFFLVVVLCFALLRFFVGRFRKPKPPVGMPPTAYVYSQTADAPPAYSPSRNRAANDVQLMPVASPESQSRRMA</sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="607"/>
            <end position="628"/>
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        </location>
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            <end position="253"/>
        </location>
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            <begin position="287"/>
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            <begin position="314"/>
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        <source>
            <dbReference type="EMBL" id="KAF2858918.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="662" mass="67645" checksum="920889ED865CA1A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR5</accession>
    <name>A0A6A7BWR5_9PEZI</name>
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            <fullName evidence="4">Mitochondrial division protein 1</fullName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
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        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="635"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="469"/>
        </location>
    </feature>
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            <end position="73"/>
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            <end position="118"/>
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            <end position="354"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858938.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="647" mass="69827" checksum="578A03D4659856BF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX31</accession>
    <name>A0A6A7BX31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_259229</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="205639at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:early endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="16">
        <location>
            <begin position="173"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2859058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="425" mass="48393" checksum="A0EDB050C5F5F49F" modified="2020-06-17" version="1">MDEDWQDQWQDSGADVDAAGPAAQLECSVSKPQKEGQGTANPYISYLITTDTDFKSFQSPHVQVRRRFTDFVFLYNTLMREYPQCAVPPLPDKHNMSYVRGDRFGPDFTARRAFSLQRFLRRITLHPVLRRAAIFNMFLESNDWNSVMSGRSKRGMSSGSDGNGTVIDSLTDSFLNAFSKPHRTDKRFQDVTDRAKKLDDDLRTVSKTVARVARRDSDLGSDYTELAAQFQALATLEPGVGQELEAFAASSRATGESWKKLKETTDQDYLGSLTDMEAYIRAVQSLLKLREQKQIDFEALTDYLAKASQERDMLASHETAGTPTAYIRQKVENIRGIDPSQSRRTRQRKLEMDISRLTDEVEKARKTSELFDEEVVKEVGDFERIKALEFRDALGGLAQAKCDFFANNVETWERFIRQMGEGSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX90</accession>
    <name>A0A6A7BX90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_277792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX90"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="130" mass="14623" checksum="043B0F25848434CA" modified="2020-06-17" version="1">MGPGHPNSHGHPMGRPRPSDRHPNDRHPMDRRGMDRPPHLSMGNHPHPSGGLLPHRPMDRHPRAPMGPMGPPPHPATGHHPRPPMDHPPIRPPYQLHDAYAHSPEEAGHRYPRSNSGMLHRDDYPPPQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXD2</accession>
    <name>A0A6A7BXD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_258604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXD2"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025607815" description="alpha-glucosidase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="88"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="385"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="17">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005988">
        <property type="protein sequence ID" value="KAF2859809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYM4"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="165" mass="19133" checksum="A361F4FF5B86FA1E" modified="2020-06-17" version="1">MESHSNPNPYQPKPGFKARYTASCHCGGVTYQISRQDPLDSKFCHCTGCQVIHGSPCQWAAIFHKLDLNFPNGSQHLGFYDHSQNKEERQLPCKVRCVICHSFILDEGRNMFLIFPSLVKFESKEDKERFLPRCHIFYKQRVIDIKDGRTKWEGLDHKSLQMGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYW6</accession>
    <name>A0A6A7BYW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYW6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16536" checksum="537BAB515855989D" modified="2020-06-17" version="1">MSDREESAPPISRTTPPSGVHLRTGHHSPHTPIEERVAAAFFPCTQPSDEEYTDSEEKALFDPAMDAKPTSCEVSADGGQTFSGKADALPAFLMHVRLKELMDSDLRDQAIKCAYAANQLRRPAQDWFVRTATAQPQLLQRWSALEAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ03</accession>
    <name>A0A6A7BZ03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_270630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ03"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="150"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="328"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="440" mass="49562" checksum="D17556D98E0430D8" modified="2020-06-17" version="1">MARDLDPESDHTVTDESSDSEREDNQQEARSHYVNLPQSKLRKRQEIPLGPQYRGKKVGREDFEEEESEDDDPFTKGFEGSDGDSLGMAEPMGDDLSDQGDLSDEDKDEDDDDDEMEEDEKDSGSKSKESILEKQKAILSTGLGAGQKADVEKGRAVKKQRETFNVLLGTRMKLQKALIGVNSLMEANEVSNHSDLIKAAETAAFNLWSSLNKLREEMSEEKTGQKRKRPAFTINSPTSELLTHMQSQESESLKRRKTTVIKWSPAIVIEEDKALAKTAKKSVMDMLESHLANTENLFKHARTPRTCAPLQASGEGSSGSIYDDADFYGLLLKELLEQKSQDSLAASSVDLSFALRRQARVKKQNVDVRASKGRKLRYTVHKELQNIMAPENRCTWNDERTDHLFAGLFGQRITLNEEDSEKSEEEDEAEDTSTLKLFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ46</accession>
    <name>A0A6A7BZ46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_257636</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ46"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
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    <sequence length="1026" mass="115633" checksum="AE9752C8F87535E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZR5</accession>
    <name>A0A6A7BZR5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
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    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
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        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="289"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="289" mass="31918" checksum="B78F0B876CE08940" modified="2020-06-17" version="1">MQRTEAPAQALSGSNISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLITHRFRFPPDSVSLYAAKVQSRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPARDFIDSATRHVLLRQGVLGIKVKIMRASNSPNDPAGEKSGAKSLPDSVTVIEPKEEQPIVEPSSQDYGPKPTQAFNAQQQQQQQQQQQQQHDLQGEEQLDETGEGQPAGGDVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZY2</accession>
    <name>A0A6A7BZY2_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_258044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="840" mass="94018" checksum="A071A12F1AB43013" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0C7</accession>
    <name>A0A6A7C0C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="129"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="457" mass="51712" checksum="FA782BFF89D29780" modified="2020-06-17" version="1">MAYSNGTQHIFNFFNHAAGSHQSFFMSDKEVYIQHCLQNLRGWDRIVQRIKASMRTILDHPGKIYDNLQRLLCELEHAEFMLARAECRFRDVRPFGMDHHRQSYGWNLAGWCDPPSGMQAFYAQRQGYARGHNSDTTSANDPSANLFNGGKKRKRDYGDDEQANAGAGKKAKQSANTNDGSSCKNSYRTPDPVGGQGSHNTPPVNHAHRGQKPPGDDEHKNTGPSWKRTCRLSPKTHHNHTTEHPSGNARSSNPHTHRTPPPAFNPDDNDNHSPPPRQRVPKLHTRDTFTTPPRPNKPTRNFDNPSFKKDKNHPISPDTLFKAYEAAWSNLPPNSSVIPYPTYNLHASPLREASYLNPTWSTETVIKANTQAFFLRAVGLRPRYRDLGRGRVELGFYHGDGDAMGKLGKLLKKEVLRWHSDRLGRREGGENLVKDEIARAVFHAVVELKESLEKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0D7</accession>
    <name>A0A6A7C0D7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270529</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0D7"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="33"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="609" mass="70135" checksum="2CACC3D9350818BE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Q7</accession>
    <name>A0A6A7C1Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_276614</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Q7"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025557541" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2860939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="307" mass="33742" checksum="28DF09792A8C5FB3" modified="2020-06-17" version="1">MYLLYDLLALLTLTSLAYAKPKPKAAMLLSTVQTLTLRDGRLTSHRRVAAMPQLTCVGGNAKGLYSIDVMRCENSGTEYGSEDIQWTCKADLPGEFKLGSTDVICEGYDHADDPYVLKGSCGVEYRLILTKLGEERYGRSAFDRAWRKPNKENVSSALFTMLFWGTFISVALFIIYKVLLGGDGGMPRLPPNRGFDPFDPRGPPPGPPPPGNDYKKPDGPWRPGFWSGAAAAAAGAYAANAYRNSQRDAGPSSQQRARYYDEQPSWLHRERTPSPPRANYGSGRNRGSSSFGGNTYESTGFGGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1U5</accession>
    <name>A0A6A7C1U5_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_257664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    <sequence length="428" mass="47200" checksum="FDF3142699F532A2" modified="2020-06-17" version="1">MATEYLAANVLNEQQQVNYRMLSRALKVHVNRAKTNLEDFYRSQNAKHAGSVHATYLITGTKQPALSQPSQPSQPSQDGDDAFMQSSPISTQGTPEERHPVPLHSVVLAKQEDLEKAKSSFDKIESVHIYSLEANGLSDIQSLANCNRDMETRYAAEDPLLVWRQYGTIHNTEVKRRTLARKPPAPEAARAPVKAEKAEKSPAKVEKPPAKEAESKTKPPPLVKQASRDSQGPSKSSSKPAEKSKQNSALFKSFAKTKAPKAKEPTPEDEPMNTFSDEEAGPESMDVDDPAPEPAGKSKKDRKAELEAMMEMEDEEMEDVGDDEGAIDKAESAMEGDKDKAEPAKAEPAKEEKETMTVENGRRRGRRRVTKKKTVKDEDGYLGTFVAVSQEGLADTKQSLRKKRFGAKAAPKKPAAGQGNIRSFFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W3</accession>
    <name>A0A6A7C2W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_25650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W3"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025492570" evidence="7">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="35523" checksum="3DF63EE65257BED5" modified="2020-06-17" version="1">MLDHLIIAAAAVLFCSAAPLPPPHFITGPVANGTNFPDPSIINDGKNWYSFATRTKGSYIHIQVARSHDFKTWEVLPIDALPNLPRWVDQSGDSATWAPDVSRLDNGKYIMYYSARIVNDTTKHCTGAATSTSITGPYIPTDENEPLICPLSAGGAIDASGFKDPDTKQRYIVYKVDGNSIGHGGACGNDVAPYIPTPLTLQPVSTDGLTFTGPAITLIDNAGSSDEGVLEAPSLTKSRGRYYLFYSSGCFTTDRYQVNYAVSENLTSGWKKAAEPLLQTGVSGLRAPGGADLDPDGKHFVFHAGEVGARGMYTARVELRGEYVSFRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2W5</accession>
    <name>A0A6A7C2W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_298995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2W5"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64789" checksum="60365902E9507720" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2X4</accession>
    <name>A0A6A7C2X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_214327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2X4"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="154" mass="17059" checksum="8901360A10E34B77" modified="2020-06-17" version="1">MPYNNTPIVLPEKVTGTATLPLARVKKIIQADGDIGPCSNNAAFAITIATEMFLKYVVEQAHNVVKAERKPRRNIQYRDVANAVARVENLEFLVDVVPKPVGVQQLKRRQAERKAESAKDSQTKAGAVLHGQMTLDTQLANRPKPREDAMEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C301</accession>
    <name>A0A6A7C301_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C301"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="257" mass="29485" checksum="15A8BC4B53B0EAC5" modified="2020-06-17" version="1">MATKTYCAYAMECLMTHLTESRTRLKFASVSDLWDLYHHRIDLSAPLEAPTPSELYIWYSHPASHAVRIVDGLKETNPLDRAIQTAAISSYACLPSLFVKRNSNIYPRIDPIICTRDELQGLQVNMVLLHNFQPPTKDPMAWELGRHGIRISLDHPTLRDGKRAYKAYTPSDIRERGFPDKPTVIASLMSLILDNIRSVDLEEEWDQYNADLVTFEGESVGLSYRIWAAWKEWAIRQPESRINGAYEEVQEDSAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C333</accession>
    <name>A0A6A7C333_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_214066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C333"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19294" checksum="46DB1F155071E84E" modified="2020-06-17" version="1">MKEPFLATSWTRTLLESQPNITKYFTSASRHPKPTTEDSLYALTLNTPDTLNATISFYTPVSNDELKTDQVSTLFCIGDGLNGHPNILHGGITATLIDEAMGILQAVNEPTGTSAGMTAYLNVKYLAPVTTPGAVLVEAKYTKRSGRRKEWISARVIQNERVCAEGEALFITPKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C354</accession>
    <name>A0A6A7C354_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_35275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C354"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="17874" checksum="F7EC7F584B507FB5" modified="2020-06-17" version="1">MAAWSYMDLGRFQTRTVAGYMVVHAQLSSLDPIRKRYHPHGNVVFDESKITALAASARRKSPLRRLDLRRPTSSASHFPCGPTSTKIAIRTEPRRLNVFAQSEDQRFTKPSHIHHDIDAGRGRDFCCCNPRVEQRNVVSRHGSKSTSTAIATWRSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3H4</accession>
    <name>A0A6A7C3H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_263171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3H4"/>
    <dbReference type="OrthoDB" id="4771581at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="20175" checksum="A0BC1221E4080831" modified="2020-06-17" version="1">MSGIEGKGPHVGQDVMVTAQISVRGGWSTCFTVSCGVVPNGTFPGELTLGRSVFHRWGVTWKGSTGKEAVVLLCFNGSPALHPAKKVPRPHACYTATESPFSPSNIKWKAPTPVDDPAVANYINHYVTQFRGLFDQSRRKTDLVAKTEHSIDTGANPPVRSPPKRCSPSQEHALRDFVKNHNGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3T1</accession>
    <name>A0A6A7C3T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BolA-like"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="128" mass="14368" checksum="8B2B3C60DE32E800" modified="2020-06-17" version="1">MLTGLCRALRYSRVLLRQRVIGYPAWYTTHDASNKPSGASPNSVRVEAPDYLDERERVVFNSLSQSLRPSKLEVQDISGGCGSMYAIDVVSEQFAGLPVVKQHRLVNQILKDEIKTWHGVQLKTRAPT</sequence>
</entry>
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    <accession>A0A6A7C4B2</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_256059</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4B2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="185" mass="19817" checksum="B76A76DF91C6CA3E" modified="2020-06-17" version="1">MENTQRLGTSPRFVEHLNISPPSTVEQDETPPSPLELSPVQSCCDESEWAPTTVSSSPMPLHYADKDAAPLEPSVPPKPPKKKRRSRRTVYICMLLLALLIAIGLAVGLGVCFAKTNKPKPSAQALPQTSALALATPASTTATNPLDCGQAEATHVLSPGSGLRDSHLQLHPDRCHNRTAEAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4B7</accession>
    <name>A0A6A7C4B7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_243317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4B7"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="64"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="63383" checksum="91CA62A116C1CDB7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4G7</accession>
    <name>A0A6A7C4G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_269007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4G7"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="12">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="607" mass="65341" checksum="EC3B1B95754E3B54" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4I1</accession>
    <name>A0A6A7C4I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_212595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIR protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
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        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025691187" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="283" mass="28127" checksum="A8359F70D5D0E6B0" modified="2020-06-17" version="1">MRSSFAVVAGLVGLAVASPMPQGVTSAIAPSASAAGCSASYSGKFEIQVVNITSKRMVKVRSKPRADALTMTLKDGVLKDAKGRTGYIAANHQFQFDEPPQTGAIYTAGFSVCPNNSLAIGNDATWAQCLSGTFYNLYDDSEASQCSPVHIQVLGGSGSNNVASQTADGQVTGSPVASVSQISDGQVQATSGAVSQISDGQVQATSAAAGGVSQISDGQVQAGTATGAAVSQISDGQVQAGTATGSAASASASAEPYTGAASISSVKKESFALVAAIVALAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4S0</accession>
    <name>A0A6A7C4S0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_263169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4S0"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="132" mass="14489" checksum="40F0B27E6001CD0C" modified="2020-06-17" version="1">MSAIVHYGFNNFQRAEALTVIYADILRQAADLDTEWLRLFNKIIKLIAVLHSPLTILALTDLLGQEDNMTVSNAQELKYSQFSLFSSSGDLTIALSPSLSPNDLSQTVTVDIKSALSPGLDRTLARTFAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C525</accession>
    <name>A0A6A7C525_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynurenine formamidase</fullName>
            <shortName evidence="4">KFA</shortName>
            <shortName evidence="4">KFase</shortName>
            <ecNumber evidence="4">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">N-formylkynurenine formamidase</fullName>
            <shortName evidence="4">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_280655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C525"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="4">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="297" mass="32745" checksum="2F3A987AE6455FD2" modified="2020-06-17" version="1">MTSPPGSAPDYTSVSYSSFSTLNTIDICLPRPVNQSHKAVWVVYIHGGAWRDPDINAASLGPAQEILLRSEVVRQIAGFASINYRLSPYLDSPYQQTSSADPAHNAMHPDHINDVLQALLYLQEKFSFDKRYILVGHSCGATLAFQVAMKCCWGQSGLNERGVKPPIAILGVEGLYDLPGLVNNHSQTPAYKDFISTAFGLDTSVWAAASPVNGRYCESWTEGRLAVIAHSHQDEMVELDQSISQLSALRRSGFGETNVDRKLKFIELSGQHDQVWHEGTELARAIQLTLHLLIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5H8</accession>
    <name>A0A6A7C5H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_280876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5H8"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="239" mass="27509" checksum="6C0A53D9DE8E7176" modified="2020-06-17" version="1">MKLNISFPANGTQKLIEVDDERRLRVFMDRRMGQEVPGDSVGDEFKGYIFRITGGNDKQGFPMKQGVMTATRVRLLLSDGHSCYRPRRTGERKRKSVRGCIVGMDLSVLALAIVKKGDGEIPGLTDTVHPKRLGPKRATKIRRFFGLSKEDDVRKFVIRREVQPKKEGAKPYTKAPRIQRLVTPQRLQHKRHRIALKRRQAEKSKDAANEYAQIMHKRVNEEKAKLAELRKRRASSMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5J2</accession>
    <name>A0A6A7C5J2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">K470DRAFT_255666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5J2"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="98"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="705" mass="79333" checksum="2010A27D15949AF7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5P5</accession>
    <name>A0A6A7C5P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_256283</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5P5"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="83"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="324"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2862028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="429" mass="48358" checksum="B0C330B483B37774" modified="2020-06-17" version="1">MATAATANGHPTLSLGIKRSNSATPSPTRSPKRARTSEPPIKTPHPQTVPFPEKPAVLEERTGEITFQVVNNDNTPHSIMILSGLKTIFQKQLPKMPKEYIARLVYDRTHLSMAIVKRPPSGSHAASSSLPGEVVGGITYRPFRGRGFAEIVFCAISSDQQVKGYGAHLMSHLKDYVRSTSDVMHFLTYADNYAIGYFKKQGFTKEITLDRKKWMGYIKDYEGGTIMQCSMLPIVRYLEVGRMLLKQKAAVYAKMRAVSKSHELHPPPDAWRRVKPGLPLPVIDPISIPAIKATGWSKEMDTLARQPRRSPSHSLLVGLLSALQTCSAAWPFLQPVNADEVHDYYDVIKQPMDLATMETKLEKDQYEVVEDFIRDVLLIVRNCRKYNAETTTYAKAAVKLEKELWRRVREVPEWLYIEQEGFEGTGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Z8</accession>
    <name>A0A6A7C5Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Z8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="14658" checksum="3D4A47B908AE90B9" modified="2020-06-17" version="1">MDNFKYTYRQLLRNSKTGVPLHPLSITQPTGSEQSNIEAGITYQNYAEHEPRDCQSPDWGIEERQQVLGNVVHEEKQDVYKLVLSVLTCMLILVLIFLFLIIVGWVLIKYLTWAMDQNVWKCKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C637</accession>
    <name>A0A6A7C637_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_212282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C637"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="421" mass="46189" checksum="D81964ED6CD8BF03" modified="2020-06-17" version="1">MTLPRLLPIWRHASRSAFHSSSRINVIKPFVLADIGEGITECQLIQWFVQPGARVEQFDKICEVQSDKAMVEITSPYDGVVKKLHYEPDDMAITGKPLVDIDAEGMADSEQQLVVPSDGNVIKGTQKPTREDIKTLTTPAVRQLTRKLKVNIADVQGTGKDGRVLKEDVHRYAAQRNQQRPSSQSSQQPTGEDRKVPLTPVQSQMFKRMSKSLQIPHFLYTCTADVGPVTTLRRQINSSFEQKLTHLPFIIKAVSIALHNHPLLNASLDAAMPELTYHASHNIGVAIDAPSGLVVPVLKGVQDMSIIQIALRLRELSTKAAANKLTPSDFSGATITISNIGSIGGGVVSPVVSESQVAIVGVGRSKMVPAFDKEGNVTKKEELVFSWSADHRVIDGAECARCAERVRKLIEEPGKMMVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6F5</accession>
    <name>A0A6A7C6F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_291043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6F5"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="85"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="402" mass="45191" checksum="973639507AA6DF1B" modified="2020-06-17" version="1">MSFEVRSHTIPATHIREYAAATAAEDDILYLAVKQYVPRDACPRGHLPITIIGAHANAFPKELYEPLWEDLSNELLVRGIWISTIFIADAAHQGESGVLNDGKLGNDPSWMDNPRDLFLMVNHFRTEMVRPIIGIGHSMGGNNLVNLSLMHPRLFAGLILIDPVIQRWPNAGNFAPAQLSIRRRDRWPSRKAAETAFRKSPFYQAWDPRVFDRWVKYGLRELPTALYPVPATEGEVTLTTTKHQEVLTFLRLRQDRNEAEIDEATPTNSAPFYRPESVNTFLNLPHLRPNAFYIYGGESALSTPASQSNQLSATGTGIGGSGGVARGRVKHVTFSDLGHMIPMEAVDRTAKACADWLGLELKWWHAEKKIQDERRASNQNKSTASEEYVRLLNSDWQGKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6I6</accession>
    <name>A0A6A7C6I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_205921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="164" mass="18711" checksum="72F2C1594A682079" modified="2020-06-17" version="1">MDIRTASRVSTKPSRFWWALCAMSMAFIMYCTPAAVRSSLSQSLLFTTTFKGKIRCTADLRLKISPCQTSRDVQEDKKLLDPRNRICSGAQFQRHRIKDRVDASGHIVQFCLTCHDIVCPDFAMVERLWFHPTYIPFGSSGGCVDTDSIKACSRSIETCLRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6X4</accession>
    <name>A0A6A7C6X4_9PEZI</name>
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    </protein>
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        <name evidence="4" type="ORF">K470DRAFT_211383</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="109" mass="12086" checksum="BDA6A5AF9FA86190" modified="2020-06-17" version="1">MAEATPRVTQPYLEQFTHSTVRLLGKVRQLRGEQATIDAGGEIVVHLNRDSHLQLNHAVEIIGRVQNDLSVKVLTPGLDMGPESNIDFAAVNAVVDATHRFPEIFYDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6Z8</accession>
    <name>A0A6A7C6Z8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
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    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25109" checksum="5B2BFE5FBABA6313" modified="2020-06-17" version="1">MPYVYDDGSDGSTGAGFTIATAKADDAARLVSIEFSAFRHETANQQLSFRDAHDASHVARAVEAYTACLAISTPVTRFLKVIDQESGNIVSFAKFEFKTYSDAELASPADVGHERDPPMNRDWFALNERLRRDYVGGKTHCYIAMLATEPEHQCRGAGRLLLNQILELADAKSLMTYLEATDTARPLYAKHGFVRVRDIEFDAGEYGVPGLRERQTIMVRQPGAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C731</accession>
    <name>A0A6A7C731_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_280789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C731"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2862478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="543" mass="59399" checksum="319A2777592EA969" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C741</accession>
    <name>A0A6A7C741_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_262732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C741"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="244"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="466" mass="51129" checksum="C78399CA92CE9D5D" modified="2020-06-17" version="1">MGQGQSGLGGPGGPPGGAGDNKDKKNKKDKPKYEPPQPTTRIGRKKKRQTGPNAAAKLPNVYPTARCKLRHLRMQRIHDHLLLEEEFVENQERIRKAKAANTLLPASAGGDSDAMDRNADERSRVDDIRGSPMGVGTLEELIDDDHAIVSSATGPEFYVSIMSFVDKDLLEPGASVLLHHKSVAVVGVLTDDADPLVSVMKLDKAPTESYADIGGLEQQIQEVREAVELPLMHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQLFQVAAENAPSIVFIDEIDAIGTKRYESTSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDQNTKRKIFTLLTDKMTLAPDVDLEELIAQKDDLSGADIRAICSEAGLLALRERRMRVNMADFRAARENVLKTKSEGEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C751</accession>
    <name>A0A6A7C751_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_280310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C751"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="273"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="416" mass="45147" checksum="2034FF3B5F855D06" modified="2020-06-17" version="1">MFNSWGLVNACGTYASFYMQTLLPKTDVLLFNLVGSTQSALVLLLSAPVGRFLDANHSFHLILIGSIFVVVGSFVLSTVNGAAKYGQGTYILVWLCQGFITGLGMACFFVTSSQVVATWFKRKRGLAIGIVASGASIAGLVYPMMNRMLTEKVGFNNAQRYVSTVTACTCLMALFAARPSPDHPWRIDVRWSKFRTYFDPTAYGNASYNWFTVGVCWLFFGFYVVFFNLEEWAVATGVGSRGVATPTTKTLSGALQTYLLLSIMNVCSTFGRLGSAYLGDKFGALRVHACVTFIAAMLILTCWTTAKTVSAAMGFVVVFGIFSGAVIGLPPASVAHILGPDHINKLGQWTGILYSSSAIFALTGPVIAGHLITAYNRNFLTVQLWSGFCLLFSSGCMAMSILKLKTSHQYMDEVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C797</accession>
    <name>A0A6A7C797_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_268509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C797"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12956" checksum="60B24577F5F3B85A" modified="2020-06-17" version="1">MRRRSSWSDSNAEDLTASRSAISPRKLLFREYLNLGKVKDENIPSGMMYRVDGIVFRSGEYAEGGHFISFTRRHDRQGFNIADDNEYVGSLDNHLQEIIDDSKFDNFFEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7N9</accession>
    <name>A0A6A7C7N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_274390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
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            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="840" mass="90210" checksum="39DEEF4FECD25854" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7S9</accession>
    <name>A0A6A7C7S9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_210527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 480.64</strain>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2863279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="115" mass="12530" checksum="09F5638D6A29791C" modified="2020-06-17" version="1">MLECHLAILNISSKTTCKAVRNFLLRPNSRKIQPWKDERSVMNAPTQSIRMLIKRVTGAIKSNGCADSRTMEHCSLSLPLPMTVSFLLDSSIAASAYAGHLHSKSAIPLTLPAAP</sequence>
</entry>
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    </gene>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 480.64</strain>
        </source>
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    <comment type="subcellular location">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="51"/>
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        <location>
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            <end position="84"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863951.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="70649" checksum="6EF87FE67BB867C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C907</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="57" mass="6572" checksum="098E2610D40E52DB" modified="2020-06-17" version="1" fragment="single">HVGVHCPALAEEYGLPVNLDTFQGEDAQRLNKQWIQYSNHGSPDFYLLIKGNRRFVE</sequence>
</entry>
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    <name>A0A6A7C908_9PEZI</name>
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        </recommendedName>
    </protein>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="MU005958">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="389" mass="43104" checksum="A3CF6EB3D54854FA" modified="2020-06-17" version="1">MTPLRRCHPILIPRCYIRKSSSVPVRPKTAVFFPGQGVQRVGMTTDWSNAFPKTVKPILDEVDEILKYPLSRIIADGPNSVLTATENAQPAIMATSIVILRILEQEFGFKVADRIDVALGHSLGEFAALVAAGYLRTGDALRLVRKRAEMMAQCSRNVGEEVGMVALVCEANHLPSLIEAIHEFLGHDSEGSKTDSHSDNDYPPVQEVLIANINAKNQIVLSGRIRRINELLTHLRQFAGHDPRAVRLNSDSPFHSPIMEPAARLMDELLEQPSTVDKSQDVVTWPGNMPCISNVSARPFESKEQLKHYLARQCVETVQWHDSIVYLHKEAKVKRWVGIGPGKVGRNLVGKEVGMKGSVRGGGVWAISDPREVEGILRELEETEHVGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C953</accession>
    <name>A0A6A7C953_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_240158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2864096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2864121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="129" mass="14605" checksum="423F0FA0F2D2B494" modified="2020-06-17" version="1">MDTALGELYALVENGIKPNFAATAKKHLVNRTTLFKRFQGLTVDRDTALEARRGLSQKQEEELIKYISFMCDWCLPHSPATGRTLTSSFSSIASPIRFWWPFISPTQPTVFSPWMWVCSSLWGTTTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9I3</accession>
    <name>A0A6A7C9I3_9PEZI</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="102" mass="11425" checksum="D7698252C8D01692" modified="2020-06-17" version="1">MGVFSILPDHLSVIETWLVRLFIVLAAITIGPWLIMLLYDFGLYAWRSATYDLPGIGGRTRGKGHPRPPSFVEHFDGNKRSLGIRNANGFFEMCEGVDDKVS</sequence>
</entry>
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    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
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        <property type="entry name" value="CPSF2_MBL"/>
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    <sequence length="368" mass="41927" checksum="CF2A797FB48DB188" modified="2020-06-17" version="1">MLPIPCLSHVYIELGTRFIWEMPYGFEKSYKKSPRFLRGENTALELIPSSLKKPYNYGILPPAGTLLPLLSRLERLQTLELGNGFCSTETLRGVFGRLGSRTTLRKLKINRFSIRNLFQYGTITDTSTSNKCDASHLSKITSDIRQCCLRFHRILNRLFTPPGARNPVDAGVDQPELAETGEFRGLKCLKIIKSSPSYPDIHAKDLATLVSKLRDLKKFVLDHAYPLRTATLIELGRNCQDLELCEFRSAFDFVPLENVQAPLFPALRYLFIENIALWDFGLKDDAKVIGKVLRRHFPSLLLLVLSDVDVRSENVLKDIQHSQYTRCGNTIIIWLVPSLGYSSEEEDDDDDDDDDDDDDADSMYDWDP</sequence>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBP4"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="608" mass="68506" checksum="9E4DF7398CBA8615" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CC83</accession>
    <name>A0A6A7CC83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_254428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CC83"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2864098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="37853" checksum="DE0652C6A09A0971" modified="2020-06-17" version="1">MDKVLQRAASAHRSTSRKLKKQKAAQKRGELFINRENFTRTQRQVKAVLDSARQNRRIDWETNTLAPRRDVGKDALTFGALPMHLYRAPELPYKKERVENLIRVGDRVVVTKGRDRSKIGKVTEVDADSLTCNVKGLNIVDVIIPAWQNQKDNREKPEVTAASRGVPLEDVRLVFPLRDPKDPNKVKDVVIEALEKIPGKGVRAIKGTNVIIPWPPKGKEEILQESENDTTMENVQEGTFSPPLLYEVMPTSVIDELRNKYSRFRTRFEHHEVEKIEQKKAANERREKLMDSMLTPLQENAQIRKTSTPKRELTDQQLEQIGQIMLAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCK1</accession>
    <name>A0A6A7CCK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_6208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCK1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12814" checksum="8F6CBE9D8E7C1B7C" modified="2020-06-17" version="1">MMERAVKSGGERCDWWWAVCRLSPAVSYRTRTQWRRTSWRARRIAPAPPQRGVIYPSGLCSTLQLEHLSYTGGSSHVTRNQSVARCHRRHQPPPESLSTLNCIKALIAQIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP43</accession>
    <name>A0A6A7BP43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_12862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006062">
        <property type="protein sequence ID" value="KAF2857160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP43"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33460" checksum="1977D583E8C59E5D" modified="2020-06-17" version="1">MPSNLTILDRKISLNPNDWTYVYPRERQVPLLVISAGMPRTGTSSLTAALKILGYNDVHHMAKVVSNVGESHYWLRAAEAKFFGRGKPFTKEDWDEVLGSCMATTDMPSAAFADDLIASYPEAKVILNYRDVDAWYVSIKETIGRMMGSWVLRGLALLGDPFLGKYIPMMDAVWVGFFGCGIEDEEGTKRRFREHYEHIRGIVPDEKRYDMRVGEGWVGLCKFLGKDVPNVEYPRVNDREAFAKALKVFVNAAVKRLVVRVVRIGVFAAVVGVGVWYTGFWGEVCAGEVCAGEVCAGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BPC3</accession>
    <name>A0A6A7BPC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_11943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006057">
        <property type="protein sequence ID" value="KAF2857230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BPC3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="84" mass="9268" checksum="A6E461733789DFC8" modified="2020-06-17" version="1">MIQCGPLKAKFENQKHLHSGVEASWWRRSGPPCSGDMHQTGEGSCHLGACPFFSLLLLLVWGPSMPIICFSLFLGALDFYSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQI9</accession>
    <name>A0A6A7BQI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_266894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006047">
        <property type="protein sequence ID" value="KAF2857382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQI9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="198" mass="20691" checksum="5C95E83A5490E193" modified="2020-06-17" version="1">MIDIALDDALAAVQSCVCSGVASGANGVAWLATGLEGQLELTGLELAAVELVGGNNVVSVLVIEIDASTEVVLADEENVVKVMVIGTDVPTEGLFTGEESAVKVSVIDTGATVPDRVLRVEGTVGGSFEDTGGCEDVGDDDGVDEFEETWVTEEITELEDAEDVDDMDVEVEEDAEVAEDLTEIEVVVDVEFDSTEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQK9</accession>
    <name>A0A6A7BQK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">K470DRAFT_223126</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MU006037">
        <property type="protein sequence ID" value="KAF2857556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="139"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1092"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1741"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1743"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1841"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1842"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAF2857556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1855" mass="204825" checksum="A78A7125A9E9156F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR35</accession>
    <name>A0A6A7BR35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_260571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006032">
        <property type="protein sequence ID" value="KAF2857670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR35"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="316" mass="34255" checksum="B59982AD165054D7" modified="2020-06-17" version="1">MTVPPKDGIYVPVPTFFKSTANGATALDTKTQSAHTLRLADAGVSGILLLGSTGEAVSVSLSERRELIASQRDTLDKARFPDVPIIAGTAAYSPEDTIEALHASSESGAKYALVLSPGYFAGSTTQQGIQKWFEHVADNSPIAIMIYHFPGVTNNLYIDPKTFEALAKHRNIVGTKLSHGIMDDVTLIAASPGIDHEKFKVFTGLGQMLLPVMSVGGAGGIDALANIFPKLLIRLFKLSAETGANAKQTRELQYHICRGEKLVAKYSVVGVKEALSRVWGVGDQKTQRLPVARLEDSNWSEWEQIFKELKQIEETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRA3</accession>
    <name>A0A6A7BRA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calcium ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_273619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006082">
        <property type="protein sequence ID" value="KAF2857048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRA3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF513">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="634"/>
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        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="12">
        <location>
            <begin position="547"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2857048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="728" mass="76705" checksum="2C3DEE8F517C0735" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRF5</accession>
    <name>A0A6A7BRF5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_260803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2857467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="732" mass="81639" checksum="0291C4DCA0DBDAD5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRS4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">K470DRAFT_196496</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRS4"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="29"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="482" mass="55183" checksum="E4692BCBB38B3375" modified="2020-06-17" version="1" fragment="single">MRRLHDAATSWKELQRYKSLDELRKTVRIGIDDLRSAYWKAFLLFQTVDISTWIQTLSSSRSAYDSLRVHFLSSKEASDPLSEVISELSVADESLRAEISQDVSRCMPENLYFRQPETQQMLTEILFVFAKLNPDVSYRQGMHELLAPVLWVVERDAIDLGLSSKLLGEDAVIKAMFDADYIEHDSFALFSQLMHSAKNFYEQTTSSGNENPMVIRSKRIVFTFLPQIDPELAFHLKKIDIAPQVFLMRWIRLLFGREFPFDDVLSMWDIIFAEDPSLEIVDHVCLVMLLRVRWELLECDYNSALALLLRYPEPVRNQAQGICIDAVYLRENMHPEAGGYLVLKYTDKPLRLANRPNTPPALQRNITMFSGSVVSTRKGRNLEAFAKDIYERGGKAVRNAVEEVNKKAQEIRDSAPLTLQGPEAVLANRRSGGRGAIAPQSQVAARIKALERRNKQLSKLLEGALNELWDFEKNDHSEDRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS13</accession>
    <name>A0A6A7BS13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_290180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS13"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="207" mass="23003" checksum="A9B72BD447C4CA90" modified="2020-06-17" version="1">MGGKDQAARGPDVVNDVDAGSLVDNFEDMVTRQLGAMESERVEGGDGIYVDGMAGDDAYEVPNAAGPWTRIVSWSSGISRSMDGCASLCGPMSESVASVFKQAKATLTADGHYDLSLKIYDKTLEEIAFTDCFRYGTTLIYWELDFENLAANNDYSNNPYVDMIAFLAIYVPIMRVMLANFVFQWNNHRIRKQKKRLHSLMPSIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BST2</accession>
    <name>A0A6A7BST2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_260016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BST2"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025715126" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="49161" checksum="41A26EB65D5E6477" modified="2020-06-17" version="1">MKGVIVLTAASAALVTASTPQVTVKGNAFFAGNQRFYIRGVDYQPGGSSKLYDPIADPKTCKRDIVEFKKLGINTIRVYMVDNSANHDECMKALSDAGIYLALDVNTPKYSLNRANPGPSYNAKYLQSLFATVDAFANYDNTLLFFSGNEVINDDKTTNAAPYVKAVTRDLRQYIGSRGYRKIPVGYSAADVESNRYEMAQYMNCGTDDARSDFFAFNDYSWCDPSSYQQSGWDQKVKKFQDYSLPLFLSEYGCITNTRQFQEVAALYGKDMTPVYSGGLVYEYSLEDNGYGLVKINGQSVSEQKDFTALQSALKNTPPPQGDGGYQSNGKASNCPPNSKTWQVTSFSGNSLPAMPKDAEQYLKKGAGKGPGFTGEGSQNAGGGSSSTASAGSGKVTETATNSGAHGGSSSTGGSDSAGSGSSTGSHSSSTASGAAGTLRPGDISIGPFVCTAVVLAGTLVGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTH7</accession>
    <name>A0A6A7BTH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006020">
        <property type="protein sequence ID" value="KAF2858025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTH7"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="248" mass="28246" checksum="01378F9081AB6051" modified="2020-06-17" version="1" fragment="single">LDRLLVNGKFSDLRLVCNSRQWAVHRALLCSRSSFFDAACSHAFREARDLVVDLSDDDEEAVEQMICYFYRLDYDIQEQTPTVELRHRSRRPKKVDFSQIRDPLLEMAGLSPPSSPCCSPRQDTPPPQSTIMETDNRPPKLLLHVRVYALAEKYDIPGLKELARSKFEISLACHYDSPEVPEAIEEVYCSTIDSDRGLRDVIVQLFMQHPLLATTPAVRALLDDMSPFMDDIRQHFGCSPAAIPVHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTJ2</accession>
    <name>A0A6A7BTJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_259789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A7BTJ2"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
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    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="75851" checksum="2A5013BB812CE849" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTL8</accession>
    <name>A0A6A7BTL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_283131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTL8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="143"/>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="744" mass="81866" checksum="2C03FE7C90950EA2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTP5</accession>
    <name>A0A6A7BTP5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">GIY-YIG domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BUL3_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
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        <property type="entry name" value="Sel1-like"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="462"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="806" mass="87357" checksum="D53ACCF22E10D451" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        <lineage>
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            <taxon>Piedraia</taxon>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="9">
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        <ligand>
            <name>Zn(2+)</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </feature>
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        <location>
            <position position="363"/>
        </location>
        <ligand>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAF2858967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="562" mass="65121" checksum="16AB96BC581F3DD8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVR3</accession>
    <name>A0A6A7BVR3_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 480.64</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
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    </dbReference>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="520" mass="56755" checksum="E621FDD0F08ACBEC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVU2</accession>
    <name>A0A6A7BVU2_9PEZI</name>
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                <person name="Daum C."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005995">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="28"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="350" mass="40658" checksum="C1D259F7DA0BA442" modified="2020-06-17" version="1">MVPRHRLRLVRVLILLSLVTLLITYISSQHPHIVQPDIHPEDSQFCKAHGFRTYPRKRKVYDLFLISTELDWLEIRLHELSPYVDYFVIIESQTTFTGLPKPAYFQENRQNFSHFEKQIIYRLIEDPGSSVGTRTWDHEDFMRNSLFNSVFPSLIGSNEEAQEGDVLVISDIDEVPKPQTLQILRNCAFPDRLTLRSHFYYYSFQFIHIGEQWAHPQATVFHGLNGTILPKDLRNGEASGLAGLFTWWYKADLWNSAWHCSSCFATLREMKTKMQSFSHVGWNTAQNRDSGTILERVRSGKDLFGRVGEYYRFVEGNEDLPGYVKDNGERFGYMLNRSGGDAGFRDVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="88" mass="9481" checksum="D2BBC18607D97CEA" modified="2020-06-17" version="1">MPFDSLPEASYYDARNRQGASLIRARQPYLIKNAVTGLTLAGFGLAVFMYTIRVIGQDDFSDVPIPDAPVNPPQTPNASVVKSAGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWD4</accession>
    <name>A0A6A7BWD4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_219441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWD4"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35713" checksum="23D5F5EF39133015" modified="2020-06-17" version="1">MHLDRCELLAHPDPLPICLAALVTTGILVSYVPQHKKLISNGTSEGLSPWWVLLGALSSIAAVGNILTLPASRQDAACCTRISGGACAAALLGIAQIGLQWTCFMFIVMLFLIYFPRDSGAKRRDGLVVGCVTLLALLFVGIISVALVAAWPNQTLTWANFLGSVAGVLAAVQYVPQIWYTYRLGAVKSLSLLTMLIQVPGSFVFAFSLWLRVGWDGWSAWLVYIITGLLQGVLLSMAGRYYMRKEHNTDASDADYTPDTLFGHERTPLLRRLQPQAIDPRNWIMRMIYGSTPPELDSDASSIARGNNRITRNNNNSDSSSNNGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWP5</accession>
    <name>A0A6A7BWP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_258630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWP5"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034077">
        <property type="term" value="P:butanediol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012782">
        <property type="entry name" value="Acetolactate_synth_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02418">
        <property type="entry name" value="acolac_catab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006378">
        <property type="entry name" value="PRK08617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF129">
        <property type="entry name" value="ACETOLACTATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="137"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="342"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="54814" checksum="3968B06BFF08E86A" modified="2020-06-17" version="1">MAAACGRITGIPGVAIATSGPGAGNLTTGLMTATTEGDPVVAIVGSVPRILSLKHTHQAMPALQVLSPVTKKGIETNVEDQTAEAVLSAFRTAACNPKGAVVVSIPMDIASGKSSHKAFPPSAFQAPPYGPAPRENVAKAAEMISKAKLPVFFLGQRASSSLVVDAVRKFIRKHPIAIVETFQAAGAVPEDLAKHVFFGRVGLFRNQTGDRLLVRSDLIVTLGYDPTEYDASSWNPEGKLNIVHVDYTSCDYGANYHPELELLGSLRQNILELADKVTHVANPAENEFCQSLSKALVSWHDQLNTKAHGSRRNSSSNSPVHPLHFIAALQERVDKDTTVTCDVGTVYIYLMRYFLAFEPHKLLCSDGQQTLGVGLPWGIAASLIQDPPCSKKVISISGDGGFMFSSQELSTAVQQKCNLTHFVWNDAAYNMVEFQEEMKYGRSSGIALGGVDFAKYAEAFGAKGLTMQSPRDVEKVMDEALAHNGVTIVDVRIDYSEAQGLAKGLVEDSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWR1</accession>
    <name>A0A6A7BWR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_258661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWR1"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="184" mass="20464" checksum="9E42EA3C5FEF82CD" modified="2020-06-17" version="1">MDHDMNMGSSSHSSSMSMVFTTDHSTPLFSNVWTPKNRGAYAGTCIFLVVLAIISRMLAAWRTKLELDWHDRAVKRRYIVVATDTERLAVEEKGEDATLTSRGVDERVKVVKSNSRDLEIPPWRFSTDLPRAALFTLMACVSYLLMLAVMTLNVGYFLSTLAGLFVGELVVGRFASADDGHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXH8</accession>
    <name>A0A6A7BXH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_218288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXH8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="486" mass="52827" checksum="87BBF93ED69339DD" modified="2020-06-17" version="1">MDTSPPPKAGPSEEPPGAPNATNAPEPPPPPSSSASTGGASAAAAQQPKVVQTAFIHKLYSMLEDPKIQHLISWSTSNDSFVMSPSSDFAKVLAQYFKHGNISSFVRQLNIYGFHKVSDVFHTGSPDSALWEFRHGAGNFKRGDLAGLREIRRRASRHALIQRDSFTGPKQLPLATPTVDSMPDPDARIGILEWHQQDLHARLARTEEAYNAMRVQCCRLLDGLTQAQRLNLELSGHVLALVPESDTRTHRELGALRQSISRHIESLRDDSLNDAGAPASPRQRLNPSQAARMPIRGPVPTHVQAARQGSMSGCTYSPSRGAACPPPPPPFSSLTANLGRRHTFANIRVNGWQQGARDVSPHSTHNPSAWPSSPHVDQNLRDSLSAYELPQGNTRARDSQASSRQPSPPAQESSAASFASSFSSFANPNDAGWQIPGVRFPFRGLDTSRRSSMTSNVHSLLNPADTAECDEEESGSGPEERKRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXQ2</accession>
    <name>A0A6A7BXQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_258830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
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    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <dbReference type="GO" id="GO:0005736">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR005571">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="153"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="25980" checksum="15BFA32BDCE68B61" modified="2020-06-17" version="1">MAEGQNREVVRLWRVLRTTKQMCADRGYKLPEDECNITLADFTRLYTNDGAVLRESMCFSADPTPDMIEKYTPIARAGQPKPEAAIGRIYIQFNNDANVGTKQLKNFAQLLNERNYQGGIFISAAKPTRSAAKLIPSVLPTVLEMFQEEDLLVNISRHELVPKHTLLSPQDKKRLLDRYRLKETQLPRINHDDPMARYLGLRRGQVVKIIRKSETAGRYASYRWTI</sequence>
</entry>
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    <accession>A0A6A7BXV1</accession>
    <name>A0A6A7BXV1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258227</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="387" mass="43509" checksum="9E2CE0450D50DDDA" modified="2020-06-17" version="1">MESTRRSVRGPTDMDIECITPKKNSFAKSKNIHMPMELLLKFARYLADDWSSLYAFTLVCRDCAEAGTEVLWSTAGLTELNQVPAGRKQIYADRIKHLVRVTEADGSPAETDVEFPRVRSLCLDFNAASLAADVVDGVEQPERGKLLVSKLAKFMSRMPLLKTLDAHLYLSSDDKTPYILNPTILTPNIEVVQLSEASHWCLLQDLANRRLGSCDSSVYARVRSGLNHVDVTLTNASPEFFAALCTVPDLKTMYLRIDDENLADAVLNKHALSCINQLTELSTLVILGRDRPLRKKVFAVDESDWINLFCNLKKLWGFSLQAELDVLPLRERVDPFERCDDQPQSAAMLDLGNDFEEIFQDGDEEDSDDDDQDVFQADSQDGSKQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY04</accession>
    <name>A0A6A7BY04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_217779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4202871at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="475" mass="53358" checksum="DA285FE5C7E8FF23" modified="2020-06-17" version="1">MAPSHSSVQASLDDFEARELSPIFPDSEMSSRRSHSPPAWRKTGVPWFAPHDALQDNNDDNEEEEDEDNDITALQFARRLPLPRSPSKGRTPEPPAKEPDPSNYFRFSTRLDVVHKTQPVEDAMAALRRLAARGPRSRWHALGYVMVACLAWMLLVGVASVPGNGGVPDLVKVAGLAKSLEPAIYYSERGHAQIGELQETGVAVWDLGESVRSTNMSSAPIIVRQLDGLSDSIKTLAIELTRFFAGVDGDIDNVLLTMEWAQRELAGLDDSAPGTLGAVWTGTQNALALVGARSVIGLSRQQKTRETLERVFTEYLGVLEESINNELAHSMQLFQLFEAIDMQFLNLQRSVIREQDTQEKLENDFLSSLWTRVIGASASQLRKYAKNRDLLASVRERTVRNKHVLVDHNQRLRQLQSNLETLRRKLVSPQVRRGQSTTPTIEDQMRGLQSTYDQLKTSREVQRRRVLEQVYGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY81</accession>
    <name>A0A6A7BY81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_282205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 480.64</strain>
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</entry>
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    <accession>A0A6A7BYD9</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="EMBL" id="KAF2860386.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="239" mass="26238" checksum="7B8E463A7B40DE82" modified="2020-06-17" version="1">MFKSPVLSGGLLWKRPWRTSPPQKLRQRRRLRRVDNVIATLDSALRRGVALHAGNAKSDTVKSDAAKGDLSAYRHGRGPRLGDLAPGTPHPKLGIMGENSAFDVAGTAEGKTRAQVLETMSARGEGRSALAERGRAMNSAASIGPTLTANPTDPGTQTATPNGPIVRAENSAITMGSYARARGTFKLLERWKAEMPTEREMLPKDKYTMFDRKRRSYRKGVHLLPKWTRVSQRVNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BYG5_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Actin-related protein, ARP5 class</fullName>
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        <name evidence="9" type="ORF">K470DRAFT_270792</name>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
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                <person name="Bloem J."/>
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                <person name="Kuo A."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54449" checksum="11AB00EC92D415B3" modified="2020-06-17" version="1">MTQLRSYVIAGRLPTGHKIGNEFSRRILPRTTLTRSLSMAYATTVNVATDLKPVYSRKGISKEATDKTNELLQKNHDQFNIFFNNKGFHNHIAHHLLTIWSLRATEDQVVQAFKDNESYQMPAKEVHEDVLKELYDPKKFSESLGVREYYHEFLIYFQKEIEQLGWQKAISKHVLEESENNMLVRLYAGLVHPIIHLGFGVEFEQPAIVAEALAETAVHRDDLAEFFHDSEKLAKENDDKSPKSIVQMFDAIYEEKTLRDAIEFRDEDKLGTTERGKIGDRVKKFASQFHVQPNDLERKNAELTNASAYLMGAAPRPNKIVKFDFFLMHTVTSSIFLSAFLRQDWIKDSDKARLLAWKSRYDLVEYVARGAPELRIEVIRNYKPKQPSGWDVLEDRVVAVPDDGHAAKTVRALAHGQRICEPYEHRPEFRIKHDDWLQLAHMTIDSVEGPGDEWIRNTGFDEAWKNVPARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY9</accession>
    <name>A0A6A7BYY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_93091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY9"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59881" checksum="601EBCF783982B95" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ18</accession>
    <name>A0A6A7BZ18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_264445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ18"/>
    <dbReference type="OrthoDB" id="5427670at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="182" mass="20203" checksum="17E3B47B7B434D5A" modified="2020-06-17" version="1">MGELVTEVENRGRYKGFEGGVVIDATERSGEARFVNRSREPNCEAVKVVVDESPHIGIFAGERGVKSGEEVTIDYRLDCNSEKCYRGIPSCRRGLGRKRSASVPEEKKVPKTRGRKRKAKEDVVTTKTPPEEKEAGKRLLNAIDGGVGLDGVGVKVKKADQMSERDKRWAKRARQMKDAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ27</accession>
    <name>A0A6A7BZ27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_74713</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38202" checksum="5A39820C0C52C0B8" modified="2020-06-17" version="1">MLEENDKHKQIRILVVLDALLSNMEGEQQRQFNTDDKLVGCLLRVATQAPDQDVRRKCRALIRSWSDVHSGNTRLANFSKLNDRITTNKDATAQSLQKRELSKQAASRQRELSQGASQQGESSKFQQAGPSQQTSPAQRRPPPIPPARRRFSQQTISPTAPTSATSPTSPTSPSSLRESLVRRFSRASNRLSNRSVENLEPTTEYEALHYEVRRAVRNLRIVVDDMEWHRHDPSTLYTMQDTMGECIKIKTRVEARLDSATDPTEIKFLEQDLRALEVATDNYNKAWVRYAGHTTDDPALTARMGPLLAPYRSEAHTRQNRPVDDDEENPFNDPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C094</accession>
    <name>A0A6A7C094_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_257749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C094"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2860732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="165" mass="18981" checksum="2E9F751CDD39C7DD" modified="2020-06-17" version="1">MRAALRPLQFISAREVEVGHGRKAIVIFVPVILLGAWHRSQQRLTRELEKKFSDRHVIIVASRRILPRPKRSNRSRTTQTQKRPRSRTLTAVHDAILGDLVYPVEIVGKRIRTHTDGSKLLKVILDEKERGGVDYRLDSYAEVYKRLTGKNVHFEFPQSGSEYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0G4</accession>
    <name>A0A6A7C0G4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_216190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0G4"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="372" mass="41081" checksum="691015EBCF7ED7F4" modified="2020-06-17" version="1">MITVKALPSCRPQTWDAVAHHVGKPPRCFRNPWPSFKEHGLLEVFKLRFGSNVEKNFVPVPQGPNGERSEELVRVQRPDWGSNQKDRLRATWLGHASFLIETPADEGCERGIRILCDPVFSDRTSPLQFFGPKRYTPPPCALDELPDIDIVCISHDHYDHLDYTTIKQLQRRFGVNLHFLVGLGNTAWFTQHVCQATQVTEADWWDRFQVAVDGVGNVVFTCCPTQHLSGRTPMSLSQTLWCGWAVESGGKKAYFAGDTGYQAVGAPSPCPAFTAIGQALGPFDLALLPIGLMSPASFMGSVHATPEQSLAIHGEMQSRLSIGMHYGTVRGGISSQYEDVRDPPRRWKAAAEKEGIWGSGVALINVGETVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0P0</accession>
    <name>A0A6A7C0P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0P0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="225" mass="24506" checksum="5D785889F5E754FC" modified="2020-06-17" version="1">MSDAPCFTLPPVLRVSIIFNCKLKEAVNAVDHAPTPRWYFCTTKHSDIAVDSRISAIAPYFAKVQTKHGKSRMNLGKLRTFRKLLSTNASNLRGWPRSATPVLKYRGCGRVEAGRGCDLMPVAPRTMSSELEAASEKVGNTSPGDSDNAMRGPCRPVHSGRSCDTCACLGCVWGRLLFIEATPLRCCRATALLHINTVFPHQYDDDPLPEPGIAPVDGVTSAFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0U4</accession>
    <name>A0A6A7C0U4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_263948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861120.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_MYND"/>
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        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="48150" checksum="53D9781BE42BA1E8" modified="2020-06-17" version="1">MADESTPTPVMDDEHKGLKNYLSTFSHFHRQPKTLHGNDNRWVFAIRRTLLYPKAEFILAIHPKDKHAVLFGGTRIYLEWDDNERAFEASKLLLEAFCDQLGDNPALPKARPPLPMAPWTWAAEDHVLGEQMQSVLSSLPIPIELKTVHAATAEECLQLDNAWYRISMAEIVANSRGMVPALFWPWTNRVLCERCNEMEPSGVTFKTCSRCLGPRYCSKKCQTDDWRVHHFDCDTRGALKETLHYFTSRACRKPEALTLARKINIRLPTCSAEFKGFSLTINRLIRFNQDTPGNFALFFGPFWDEALQPLRENITIAISFGTREGSFRALKDYKMDPNAPLRKEFRVGPWELRMEKKLVDMFSCCASEELTWQEFKNILAFNEPNWESALNLYGILGDIMHPSDMPTLPWTRAMIPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Z1</accession>
    <name>A0A6A7C0Z1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_276383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vacuolar transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CID_dom"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2861236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69613" checksum="D0355016061D3CDC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Z9</accession>
    <name>A0A6A7C0Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_216196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005977">
        <property type="protein sequence ID" value="KAF2860907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0Z9"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="21531" checksum="60A945AA568E2D6F" modified="2020-06-17" version="1">MPAYHSVFLDEPNQQLIGNFALLPLRTKTRGPAQQLNQLVDVSELDIEPNHADYDILDEVISLFRANTFFRNFEIKGPADRDLIYGILFVSEALSKIKPGMSRREAEKAVMNTALDTNFAIPGDAGFPLNQAFEAPASRDQAELLRQYIVQMRQELAARLLNRVYLDGTGQPSKWWLSFQKRKFMGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C134</accession>
    <name>A0A6A7C134_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_64789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2860655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="105" mass="11447" checksum="08749D5F70382C9F" modified="2020-06-17" version="1">MAALCIKGPHKAYFTHSTTVLNNGSTLHSTLNITNGTPYPWPGTSTVQATNLTPRTVASLISGCHDNQEFKAFPIRPIDSQTVELDLHFPRNTIPTRAEFLIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C170</accession>
    <name>A0A6A7C170_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_281703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="120"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="308" mass="35347" checksum="4E6E748091702809" modified="2020-06-17" version="1">MADVRLTLRWHNEPHEISLPEKSTIQDLSTAVAERLHVPPSNQKFIVTPKIGLLRPPFKDPSLPIQSLLDRKIILLGATEAEVATLDSALATQRAQAQRREETLAKGRRVLAYRHIDSARAQDEARYTFHAIKPLPYLPHPEKSRRFLERLRDDPGIKASMRKHGFQVGLLTEMDPVEHTTHQSRTLGLNRNRGEMIELRLRTDRYDGYRDYKVIRNTLCHELAHNVHGEHDRKFWDLCKLIEKEVERNDWTRGGRSIGGDEFFNPNDEGHEHVDEGGWTGRTLGGENETLSRETLARAAEGRMGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C171</accession>
    <name>A0A6A7C171_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_257169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C171"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="173" mass="18700" checksum="6565623736D697CC" modified="2020-06-17" version="1">MPALDARIIVLALRLAQALLALITLGLSGYVIHWWTHYWHIGSPSSANFLLFTSLWTLLAILALILIPWRLSATKLNHKFAILGIETVTMIFWFAGFVALAVFLSDRVCYGPVCGAAKALAVFGGFEWVIFAATTAMAVMHALRTREPKGSHGPVNANSNMMGDAPMGSGMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1C4</accession>
    <name>A0A6A7C1C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1C4"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="290" mass="32570" checksum="CB5CBAA78AAC8024" modified="2020-06-17" version="1">MDSMNRITPFLPSQRGRNIHQSPAEGYSIGSNDTGQYSDSDERNEGDSDEQEAQQPDDTQGDNDGEIAASQREVNDPEVVSNFREAARSVTTLFRSGLDAQKRARAAGYQDTLGDLLRYIDQHNIGHVYGTEGWKIRQWILARLLLASQREQSGTGRVEEEDSSGPSQPERRSPPPNDDSSDDEMSGNVQQRFAPQPSLQARSPRQVAQTPRPPHRSPTSRMRDIRVQKDAHSKLVKRSKSSILRQQRRSRSENRPKHINLGTGTGTKRRSPFVDVFADPSTMSKKGRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1E5</accession>
    <name>A0A6A7C1E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_207152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1E5"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2860775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="557" mass="62407" checksum="45A045F3C69F7AE0" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1F3</accession>
    <name>A0A6A7C1F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3 10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_299474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3 10"/>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025687416" description="DNA-directed RNA polymerase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="309"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148955" checksum="C4F672A32F5AE149" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L0</accession>
    <name>A0A6A7C1L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_256841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L0"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2861456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="566" mass="61736" checksum="B269711D2F0C611C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1T7</accession>
    <name>A0A6A7C1T7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_256824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1T7"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="363" mass="41749" checksum="256DACE763BDC772" modified="2020-06-17" version="1">MATMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGYPSEFAMYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQASASQTQGQTGGDDDDKVGRSRPPTTNRAQAGTKRDNQHSGMQLRSQTKRVDQSGYGNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C239</accession>
    <name>A0A6A7C239_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1770-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_215149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="17676" checksum="D4ECD6CA182CC8BB" modified="2020-06-17" version="1">MEDAAIQVAETIQTAHIQRSPSIDHDVNPSTAASLKEPVVLDAGPDEASFVDSGDIPASVLRPAPRRPQMPPIPDLRFEQSYLASIKNATDWKSVAYITIRDQILFPLIQGMAWSLMILGWHHLNRESQFSGQSMGAKVRRWWWGVNNWAVPAKLRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C6</accession>
    <name>A0A6A7C2C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_215263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2C6"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="459" mass="51750" checksum="D79B5222565398A5" modified="2020-06-17" version="1">MDGRAKQPSSVHSSPTRAGNLFADYNPHSPSKTLPFGSALNTSPSLPEFTAVKLQSNSDVQGLVKRFEHLDVRDRDAETRKRHEAELRRARIAREEAESDARKLKEEAEQLRAELGESRERERRVAERLETMMEEHASEKAQLASQVGVYEKEVRKYRKEALKSSSAVIKLQEDIKSMRSKLQIANSGLDVEKEKVQRREEDTFSAQYKLAALQEEVEKLRAYVKIADEEKEALKKNLREEEVARIAAEGKIALPEEEDVDMQRLSDKENGGTVSKKTTTEIKTLKDDLLKEQMLREHLEEMVEFLTLECRFQCCSCRGSQRTTEKAAGETAINNTHEAEPDPQTPPESPRHRFVRTTTTTTTIPMHFTPVTKPTAVDFTPSAVEDAENIAPAGSFDREAALEAIKYRRDRARSFATGHLTPRKQMLVGVKERRDVSAPALGEKRGSALNRTPGRGTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2D0</accession>
    <name>A0A6A7C2D0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2D0"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="107" mass="12074" checksum="1C1E49C2D8124C13" modified="2020-06-17" version="1">MAPEVRALAESDIHAFGVLLYSLLTVKVFDNESFDYTAGFFREEIAKTSMASDREFVEFVLRVLSETPGERLGTKELVEFGVSYKQRVAQEVSGVRFPEGTFPKPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2M9</accession>
    <name>A0A6A7C2M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_214245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2M9"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47368" checksum="C430AADA31A700AC" modified="2020-06-17" version="1">MSLLTLSNELLHLTFLSLNPEDLASLSRTNKFLHTFITTNTLLHRDIYLTHYDPPPPPQNYITLLHEVTQLENILNNYTDTFTERRRQLYLTFVHRVVIFLLQTAKRENSGNVKRLVGYFCDGGNRDAFLCEGEASCQKRAKLSCLVGGSVDVPIKITLCPHLDDDIHSAREHVYSIRNYSRGSFWGPFRDDGSGRVDWVKTLAIVRLLGFNLSHSGERVKGEVSETWWEEFGGVTPIPWGGGMPTAGVGTPVADPYGVTGTWKRVVCFLDYTEFYAFNFNGQLGIDASQEGESSDAILMIEMKLWVTRIDPVENGRLPVVHFKGTSTLLAVEWTAQRTSQIRGTVQETPEGEIRWTTLSIFNGEERWKSEGIQIGGLRAARGVVGSWFHKDYDPFGPVGPSAYWKVSDEVGNLPDGFEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q6</accession>
    <name>A0A6A7C2Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_213954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2Q6"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50084" checksum="92D57888F35E0074" modified="2020-06-17" version="1">MGLSNDERGWILSLLSGAACVIGSSIICVDLLVRQFPGKRHFRIQESDAFLSLSLSLSSGVMLFSSLYSIMPSARNSLEQGGLSSKAAAWTLVACFVGGIFGIQLISGVIHSHMPSKIVDCEHSHDGDAHSHEAHNQTPNLSSEHGQTAKGKTATESQTHQQIGYSHPSKRPNTEDHTDSNQTRRMKPDRPPFRQRLTNRITHLMNSEGSSCDCVGSCYGYSDICGQKCFTNSIAEGSRTGSEISVSMSKESTARLVISTNESTPLLGNTEREMVPESSNGRSSSSSSTLQHNENPEAGHGTDIHHHHVPTNAFLSVGLQTAIAIALHKLPEGFITYASNHANPELGLSVFLALFVHNITEGFAMTLPLYLAINSRLKAMLVSFVLGGLSQPAGAAVAALWFHLAGREREPSEAVYGGMFAVTAGILTSVALQLFRQSVDHTHSKRLCMIGAFTGMTILGISSALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C310</accession>
    <name>A0A6A7C310_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_256399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C310"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="178" mass="20271" checksum="8A271B53C3A55C24" modified="2020-06-17" version="1" fragment="single">MQPGRANGTVQEKAQYHLSQLDKELSRYPMLNNFQQQTNVPKVYVVLGLGALYFFLVFFNIAGEFLVNTAGFALPAYYSLQALFSQGKSDDTQWLTYWVVYAFLTVIESAINAAYWFPFYYIFKFILVIWMALPSTAGAQVIFRSLFYPLFSRFFEHGAGTSANLRAQADPVMAGKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C342</accession>
    <name>A0A6A7C342_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_263561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C342"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <location>
            <begin position="142"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862093.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="215" mass="24440" checksum="098B4323132646F9" modified="2020-06-17" version="1">MGYYDEDGHYHSFRHGMHQATDRILYGPRHHHDRATEDIVVENREITTSAPRYEAERYQVRRSLRQAPNTITIPCHHIRIGDILILQGRPCQVIRITTSAQTGQHRYLGVDLFTKQLHEESSFVSNPAPSVVVQNMLGPVFKQYRVLDIRDDGRVVAMTETGDVKQGLAVIDQSSLLQRLSDSFANGRGSVRVLVINDEGRELAVDYKVIHGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2862082.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="692" mass="79175" checksum="558E2B83A5E94C04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4D3</accession>
    <name>A0A6A7C4D3_9PEZI</name>
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    </protein>
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    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="65"/>
            <end position="104"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75878" checksum="FC3F5579E8A735D7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4D5</accession>
    <name>A0A6A7C4D5_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="416" mass="46723" checksum="58D9156E97147B59" modified="2020-06-17" version="1">MAELGVVETSSQDFTEDVDMLDYDESMDVGYSVGINVENQIVSRLSHESQGGPNIEGGHDSDMESDIEDEGDNGREEESEEEEECVDDGMEEAERWEDEAYGQGRGSDEDEDEAEAEEGHGDEDRNQPHYSRSSRFAPPDPVLIAEPEHEYSPFKCEIDALFFAFYVSTHRPVSDKTMNSIIELVKSALEIARTTPDGTISISSVSKLKRYKNAVPSPETQRRVTPEGKSFHQISILDSMRMEACKPGMKLVQYPEILKPAPAFSGEEKVAANQMWHGGKWRTERQLLRPVDGLRLREGRQDVWISDVLELCTGEHAMFYGCEIHTTREQSALVVRAIKLTRARPTAPSSKKARLLLPIKEGHWIFPKKQSFYWTSGISSRLRKQPSLSLLPKTEAISTLTLSKCFVPHTPQGGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4J4</accession>
    <name>A0A6A7C4J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_213183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="MU005967">
        <property type="protein sequence ID" value="KAF2862293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4J4"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="569" mass="63018" checksum="590CA5B234EA53E1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4N0</accession>
    <name>A0A6A7C4N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_269444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4N0"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2861915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="423" mass="45349" checksum="D59AF3C55DCC127C" modified="2020-06-17" version="1">MPPKPTKTQTLRILFLSLLLDLLSFTFILPLYPSLLHFYQTSTPPSPLLHKTLLTLQTYKSTLSLPPGEKYDTILLGGALGSLFSFCQALTSPFIGTYSDKYGRRPALLLSLAGNILSLITWTLAPNFEFFLLSRVIAGLSEGNIQIALTIVSDVSSEKERGGAMALVGACFSIAFTFGPALGAGLSRFAVVERNPFAVAAGVALGLVMLEAGVVYVYLPETRAGGREAPHGRDASRNRHASRTNSHALLNTTQLLFVLVFSGMEFSVPFVMFEMFGFSAEQRGRVLGYIGLVASLLQGGVVRRMKPLRAVQVGVAACAAAFFTLAGLETQMGLYAAATLLAVTSATVVMGLNSLSSLEAGSGERGERLGNHRRFGQVGRTLGPVVFCSVYWWVGRERAFIIGGLGMVGVGVLVGMLRQPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4R1</accession>
    <name>A0A6A7C4R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_255995</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4R1"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="462" mass="52936" checksum="E882BB90D7B9BEA9" modified="2020-06-17" version="1">MAMEDDLAAQLSEQIESWSCSSTDCFHISLLRPNGELAAGPFNPKFTYPIFGDEETIFGYRDLDISLTLREDDLYPHLSVKYGEKFKGVAEVQPTDIQDLMKDFLPEKAFQEAVQQSQSFTPPGEKLAEHNHSGKTCETWTCSLADPKAREILENMQIFAPLMIEGGSLLDLTQEYTAERWRLFLYYRVQDGTYSLVGYCTAYILLYLPNSFASGAFSLDDIINNPPADGVEAHYPHRSRLSQFIILPPYQGCGHGRNLYRDVFSNLTAPKAVKEMTVEDPNEAFDDLRDFCDLEYLRNNSPAFADLKINTSLSASNDDSPFPIDQIVDGDTRRTIRVQTKLEERQFDRLVEMQTLSRIPVANREKSRITRKEKCSNPNDRAFYLWRLFVKERLYRFNFDQLSQIEDQERIDRLESAVDSVIEGYEILLEKAESRGKPKGKGNKRVIVEDGSDEEVAKKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C516</accession>
    <name>A0A6A7C516_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_255611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C516"/>
    <dbReference type="OrthoDB" id="4207724at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="39738" checksum="89831F4502396E8C" modified="2020-06-17" version="1">MAQETDVWKGLQNWALFVPVVVGLGAYYSLSQRRQNARPATAAPNKRSEREVRSKSAKKEDQASGEPKKRKAPPRPKGDVPAVPSTTFTEPEREDMSTKQFAARMAKAKQGTDLSAPKGGDRRVKTVKQGKAVDTPVISSASSADEATPYAGNVNDMLEPAAPGPSVLKITPPTKPAKEKAPRQKKEEPVETKKQRQNRQKKEQEKAEREQQEQQRRVLEEQQRRIARESRGEPAKNGVPAANAWKEKPAKPVVDGPLLDTFDESSVKAGAPAEVASSDGEPPADGWTVAAPKGKKKKGSKGEEGEKTVEEAKEKATHEAPKDKATTAAPTAKWIQTAKPNGYTVLGSYKQRIDVDASDPSNWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5C8</accession>
    <name>A0A6A7C5C8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_280851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5C8"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF4">
        <property type="entry name" value="GLYCOSYL HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025661117" description="Lysozyme" evidence="12">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="222" mass="24523" checksum="8EF0E3776DACDF86" modified="2020-06-17" version="1">MKLSVTTIALTATLASAYPQLGGEPDALGFDISNHQPTVDYKAAYAGGLRFVFIKATEGTDYIDKVFPTHWAGARDAGFITGAYHYAHGTTDPVVQAQVFVKNGGKWQRDGKTLPGVVDMEGVCTGFSTDWLTKFTNEYRTLTGRNAIIYTSPSWWKTCMNNTAVFGKTNPLWLARWADAPGAVPPGWKNYTIWQYNDTNPYQGDSDRFNGGMDQVKRLAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I0</accession>
    <name>A0A6A7C5I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="150" mass="16027" checksum="64D21171CA3DDEA8" modified="2020-06-17" version="1">MALLGVYGDSSSVSSWVWRVAAGERAARLHRLSGVVFKVKCKLTSYSRLVAEFKSLSPTNGEKQVEDLAKSDAAEPLVAVIEEAGARRSLDCQNVLLTTECSLSVESQLQLQGGDGDDELRADGLSRTAGNGCHKHISMPTAEVLCCTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M8</accession>
    <name>A0A6A7C5M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_268885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M8"/>
    <dbReference type="OrthoDB" id="4837779at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11276" checksum="36ED1BD35756BB22" modified="2020-06-17" version="1">MFTITTYWARTDWDLTELTLAVEEVPGPQYGENMAPIVVEVLDSPNVNDRVISMTTDNATNNDTTCTGLIKKIPFARSQHLPCIGHIFNIAVQAGLKAGQLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5X9</accession>
    <name>A0A6A7C5X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_268788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5X9"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="322" mass="36134" checksum="FBD471C74DB2F4EC" modified="2020-06-17" version="1">MAATAIVCVGMAGSGKTTFMQRINAYLHGERKAPYVVNLDPAVHSVPFDSNIDIRDSVNYAEVMKQYNLGPNGAILTSLNLFSTKIDQVMKLLEKRCLPQTEQTESTPAHILIDTPGQIEVFVWSASGSILLSSLASSFPTVLAYVIDTPRTTENTATFMSNMLYAISIMYKTKLPMILVFNKADVKRPDEAIEWMRDFQAFQAALQREDSESDGSNYMNSLLGSMSLVLEEFYNSLSVVGVSALTGEGVEEFFQAVQEKREEFERDYKPEIEKRREHAREVQREAQDAERDAKMRAMHRMTSDMSLEPETVSEAESDDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Y9</accession>
    <name>A0A6A7C5Y9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_11423</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Y9"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025587700" description="Inactive metallocarboxypeptidase ECM14" evidence="16">
        <location>
            <begin position="22"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="126"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2862469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="503" mass="56848" checksum="6DE9A3E90785DBF2" modified="2020-06-17" version="1">MWTLPMWAAASFAVAGPLVNSGPPWTNDTVLRFPLRTREEGQIFDDAVKTLLLDVWTRSIDWVDVRVPQDHVQPLLAMLPTSLQSRHRSVLTSPQLKQFVAETYAGPADKSFSPALGSGEDLFFEDYQPFSVIEPWMRLMASLFPSHVRKISIGKSYEGRDIPALRVGVHPTNNNEPPMPRRTFIIVGGMHAREWIGVSTVNYLAYRLITAYGKIPDITHKLNEFDFVFIPTVNPDGYVYSWETDRLWRKNRQPTSSSFCTGIDLDRAFSYAWDGPENPCSESYGGEEAFQAVESEQFASWARNETEHNVNFAGIIDLHSYSQSILYPFSFTCEFEPPGLENLEELAYGLSRAIKRNSGHNYDVMSACEGNAGTFAPAGGAGLDWFYHELHVPYVYDIKLRDRGTYGFLLPKENIVPTGREMFDALMYFADFLLEEKSASATDVMCSCPDCDCSICSCPDCTCSQEENEQGYVFEIKHDRKQFVHTDNVPPTGLDPDEVSWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Z1</accession>
    <name>A0A6A7C5Z1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_262918</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Z1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="16">
        <location>
            <begin position="146"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="506" mass="56210" checksum="55032DC1ABC0F30E" modified="2020-06-17" version="1">MASPRPSSPANAQSSTATTTGARPSSPKPPGGPATAIRRKAAADRDAKVANARPASTRAAGAGGSSSTMLRLYTDESPGLKVDPFVVMMLSIGFIISVVALHTVMAKITKSVIEGSNVLSSENLHHSTMTAPTVKLNNGIQMPVVGFGLWKVNNDTCADQVYNAIKTGYRLLDGACDYGNEKEAGQGVKRAIDDGIVKREDLFIVSKLWNTFHDKDRVKPACQRQLKDWGIDHFDLFIIHFPIALKYVDFSEKYPPGFFNKDGKVELSKASLEETYHAMEELQKEGLIKSIGISNYNAALILDLERYAKVMPQTLQIEHHPYLVQKDLLDLCKSRDIAVTAYSSFGPQSFLEMNMKSAHDTPTLFEHDVIKSVAGKHDKTPAQVLLRWATQRGVAVIPKSNNASRLKQNLEVCNFDLSDEELKKITALDKGLRFNNPLNWTRTCIMKVAKYKPHPVTSDKGIASRSHFRAILDRKQQALLQPYRFSHLWLRLNRGLAKMLCVLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C614</accession>
    <name>A0A6A7C614_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Putative COPII-coated vesicle protein SurF4/Erv29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_255612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
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            <end position="236"/>
        </location>
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            <end position="262"/>
        </location>
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        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2862687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="306" mass="34367" checksum="2D54C6B27313B0D5" modified="2020-06-17" version="1">MAHVRGTAGYSLGSQPVGRYNMGPSRPEATNDPWPLESIREHTSKMEDWLDTIADPVKPWLPHIGRFLIVVTFLEDALRIITQWHDQLVYLHVYRHIPSGVTHTFLITNVLTMTACSVLVITRRHTEYAVAGLIGVVIAQAFGYGLVLDLNFFLRNLSVMGGLLMVISDSWVRKRFAPAGLPQLDEKDRKMYFQLAGRVLLIFLFIGFVLAGEWSVGRVVVICLGAVACVMVVVGFKAKWSAIILVMILSIFNVLVNNFWTLHPSHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQVSFDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C616</accession>
    <name>A0A6A7C616_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_280542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3929278at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="317" mass="35542" checksum="A8D298DEDCBC8A4C" modified="2020-06-17" version="1">MMMEAKERRPVPWNQMGARKKRLILYRTTGGYDTDGVGGCRLFRTETGRRQGSSLSPSLFLFFISDLLKVFDHVHDDIFGFGFGFVDDATLVAWRSSANDNCRLLMATHDICPAWAKCYGAKFAPDKCQIMHFPRSEGSQTTSRSKIQIQGHDAERVDSLRVLEVWLDPRLSWKDHIERAAAKGLQTFEAMARMTSSVWGPSVRSSRILYAAVIRPIMAYGSQVLAVAKGGKPIPKSSIAPLANREADIAPIDLYLQTLAMKKAVQSRTDEVTMDIKRALGQVWTAAIHIAGRRRGRRRHSNQWEKKADAARSTADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C634</accession>
    <name>A0A6A7C634_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C634"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="129" mass="14908" checksum="06D17DE30F4FB169" modified="2020-06-17" version="1">MSLAPPFHGKQYVCSCCASEHHLQSNPSSEHHRHRLPQRKGLEKPATTQEIACGFNAELKILNEADYELVARKDEDIARKNRVMQWLQHVRPDGEIQVIRLRIQMCHAEQALKRTQVQAQMCSHGQTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6D7</accession>
    <name>A0A6A7C6D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_268771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
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        <text evidence="1">Belongs to the DeSI family.</text>
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        </location>
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        <location>
            <begin position="146"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="278"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="563" mass="61818" checksum="2145E860E2E23E82" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7R0</accession>
    <name>A0A6A7C7R0_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Beta subunit of citrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_241629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
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        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
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            <position position="70"/>
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        <ligand>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="314" mass="33917" checksum="BB45C49A1954824F" modified="2020-06-17" version="1">MTLLRRAQLYVPGSSSKFLHKSIGLKVDSLALDLEDSVTPSLKPAARENICQILNLPRTQSAQISELSVRINSVSSGLAEDDLSTVLSCNGAATNLDTLVIPKVNSAKDIVFVTDMIAHHLPTRDRPIKLIALIESARAIVDLSSICTAAKNLSGLTFAAEDFALDLGITRTPDLSEFLYARSAIVTAAKAFGLDSALDLVTTAYRGDKGTETLRKESENGKRLGFTGKQVIHPDQVDIVQQVFGPAEDEVEWAVKVCIADEKADKQGRGAWTLDGKMIDAPVAGKARAIVQLAGQCEYDINGLRDKHRHVEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7R3</accession>
    <name>A0A6A7C7R3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7R3"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="85" mass="9244" checksum="569B53FDAC233CE0" modified="2020-06-17" version="1">MPLVVPGLQNSASASSQNNAEEWMNRLAGKTLGDKSDETTFARSELPKSHRVVKQGQDFSQTDHDAERINIVTDDNGVVMKVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C3</accession>
    <name>A0A6A7C8C3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_254584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="361"/>
        </location>
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            <end position="907"/>
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            <end position="54"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00005460"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863690.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="910" mass="100686" checksum="3611FD4A2B36B39B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C8F2_9PEZI</name>
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        <submittedName>
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        <name evidence="6" type="ORF">K470DRAFT_240977</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="83"/>
        </location>
    </feature>
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            <begin position="73"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863522.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="83" mass="9362" checksum="C66E1567933421E2" modified="2020-06-17" version="1">MPQQVDDIKSFIEICLRKDAKSARIKKSNNGPTKFKVRCRRYLYTLSVNDSAKADKLRQSLPPGLTITETPKKNAKGKRVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8T9</accession>
    <name>A0A6A7C8T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_262145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025683153" evidence="7">
        <location>
            <begin position="34"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="14"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="475" mass="52750" checksum="28D630A6CF5172D7" modified="2020-06-17" version="1">MSPFLWPQSRKRMTTSLATLVTLLSGLVPGSYAAGEDQMAQEWRVSFVELNWGIAVFTWGFAIAPMVLAPLSEIYGRRPLFMTTGILFLIFQMLCAVTPTYAGMIVVRFLVGCTGSTFSTVVGGVVSDVYHAKDRNTPMALFTGAGIFAGGVGPVVGGVIAQYTTWRWIFGIQVILGVIVITIIILAFPETRGSVLLSRKAKALNKWYDQLESAGCYGVVIDGHSQRVRWKVKADEERQSIDNIVRISLCRPFCLLATEPVVFFFSLWISFSWAVLYLLFSAIPLVFQTNHKFNQTQAYGVFAALSIASAMSTVISIYQERFAERFVCGKRRRQLKTPEGRLYFSCVQSILLPIGCFWFGWTSFESIHWIWPTLAVGCTTMGIFSIYLAVFNYLADTYHRYASSALAGQSFCRNMIGGAFPLFTCQMFETLSYQGAGSLLGGLAAVLTVVPWVLVFYGPRIRARSKLASEVVCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C977</accession>
    <name>A0A6A7C977_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_262006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <location>
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            <end position="281"/>
        </location>
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        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="392" mass="43813" checksum="8DC675397A1F9D78" modified="2020-06-17" version="1">MHYDATHTWYNWSALSHSPNLKDTTRYLMNYTPMERRVTFYQQVTNDGNITKTIWAHFDSDGELGYGVEVPNQAYIEQKTRTNINKRAKDLEIQDIEKKLLGALDVASHLWSAFGHAAPEPPKTPVHSTEHSGQLPEQYSHDMSPAHRLSVLAVQRTHPHQPSPLHSSIQPLQQQVGTAHIGVKRPREAHEGPNDCERRVKPRMEECTYQNAHVQAPAQRQAAATPQLKRADNILNQVESLSNPGGPQQLQAATRPTEVQACPTPRPRRATQTPTPIFSQRHGGMFSFQMTRMPQRFNRSTAQIGTSTPSQHGSGIHASQAARTVQPYTQPATQVATITPAQQRAQRAARIMQYTQRISAQPVLRPHDILGMSLPQNVARPPQAMAVTRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9M3</accession>
    <name>A0A6A7C9M3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9M3"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="80" mass="8839" checksum="4A1A950D0B551FB8" modified="2020-06-17" version="1">MARKSPSSKSWLYHHFDHDVSPDTKVTLFIGEMLLQELLQDATLLAYGCLIIDEMLEQTAGADTLLSAVGKCGSRNTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9N8</accession>
    <name>A0A6A7C9N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="292" mass="31095" checksum="C71D1CF7811C6DFB" modified="2020-06-17" version="1">MPPTPPIRFLLLSSKRSISSISRPNPNFERYNNLPGHAPLRASRAGSLLVKDSNLSLRTGVLAVKKGMTAIYDPVTSVRTPCTVLQLDRCQVVGHKRRSKHGYFAVQVGMGTKEARNVSRAERGHFAKQGVPIKKEVVEFRVKSAEGLPPIGSLISAGVFKEGQFVDVKATSKGKGFAGGMKRWGWAGQPASHGNSLTHRAMGSAGASQGSGSRVHPGKKMAGRMGGEQRTVRNLKVMKVDVDNGIVVLAGCIPGPNKGIIKVQDAFKKSPPEGVDANTGLSSLAKEERAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9U3</accession>
    <name>A0A6A7C9U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Park H.-J."/>
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                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16809" checksum="73FD2ED5A105954C" modified="2020-06-17" version="1">MTHLFEQVFMMGEPTSPRLGYSPFSFVKPLAHKIIAITMDNASNNSSFVSIAISNGLVKGRDCLMRCFAHVLKLAADSALEIIEPTLATLEKLIKHVRDDDNELVALEKHAKKRLRRKGSRYLAMRRGGTRHSTCSSKRSYKSLYMCSF</sequence>
</entry>
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    <name>A0A6A7CA41_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="13" type="ORF">K470DRAFT_241697</name>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 480.64</strain>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="228"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
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            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132577" checksum="0BB9C0FD9EE08561" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA85</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Lipzen A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2864313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="129" mass="14047" checksum="AE6806C471BD43C0" modified="2020-06-17" version="1">MSPLEVLGIVGFVITSSGSNLYVIAICLARCRAKKQADTELEVAAAGTHPHATPLRHRLPASSPSLDRAHNEIPVFPELTCMEDDLWGIPVHSPPVPAAPVESNAEDEWDLMVRYKGFLGPFQEAFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAE7</accession>
    <name>A0A6A7CAE7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_254289</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2863975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="549" mass="59156" checksum="D626A7C243750DD9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CB34</accession>
    <name>A0A6A7CB34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_274146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2864195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="transmembrane domain of human cd4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF23">
        <property type="entry name" value="PLASMA MEMBRANE SENSOR TRANSDUCER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025619802" evidence="9">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="346" mass="35777" checksum="60F9C39C100E45A0" modified="2020-06-17" version="1">MLAALVVLLLSASSAAVRAHDALLQRHGLMKRQSMTYSGCYSSSGSLDDQGPYMYQTSGYCQPICLKKNNAVLGLSGGSDCWCGDTLPPANTKVDDSKCDSPCNGYGSDKCGGQGFYSVYLTGLKANVGNDKPMSGTTANNDGAAAPSPSSASTVASQAESSAGSSSSAATITGSTTDPSDSVTGPVVFRTDPPTTLVVTDTSTVSTPTAAAPPPKSSKGGGKSNTVGIAVGVVVGILALLALLVAFFLYRRHRKRQAEKAAAQTEKIKPFFAERDPNHIPPSTTITSRRDFDRDSIGSLVDEDRPITQPGRVLVVSLLFCVKRSALTGLAGCKSRSGMKACVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CBQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_6739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CBQ1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006050">
        <property type="protein sequence ID" value="KAF2857332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQC6"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2857332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18711" checksum="B4E5523F086699A6" modified="2020-06-17" version="1">MYNGMVCGQVKPTVVNVKDSLLGFDIDTSEVFRRMKKKPRSAILFESRGQSRAQGEQVRQAFLHYEKNGDWYIEPAITDAFGVFMVYPIDLVKTRMQNQRQSRVGQLLYKDSMDCFSKLLCNEGTRGLYSGVLPQLIGVAPEKATMLMFNDFVHGKFNKPTLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQP0</accession>
    <name>A0A6A7BQP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006036">
        <property type="protein sequence ID" value="KAF2857591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQP0"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="194"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="451" mass="48661" checksum="53E1B09B02DAA241" modified="2020-06-17" version="1">MLSRSAIGRSAKQCRFQQNRGLAEPASGSFQYQTGDAAGVKFASRDIPGPVSTIGLVSQAGTRYQPLPGLTEGLRWYAFKNTQRRSSLRIQRESELMGGMLGAYYDRENFVLGARFLRADLPYYLELLAEVATMTKYQNHVVNEEVLPLIKMDQQKYLSNTLEMAVNSAHGVAFHRGLGVPVKPSSSMPVKQYVTAGDIAEFAASAYAKPSFAIVGNGVEHGELEKRVKEFFPNVRAQAAYPLKSDQSKYYGGEERIAHASGNSMVLGFSGSSSPTGPFYKPAVAVLAEILGGQSNIKWNPGFSLLSQAAEGKPTLHVKTRSNIYSDAGLLTVELSGAAKDVAEVAHKAVEALKGLTQNIDKELFQKAKAAAKFRELENGQSTKAAMVLTGAGLVHGGKAYQIDEVAKNTDSVTVEQVQKVAKEALENKASVSAVGDLFVLPYAEEIGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR68</accession>
    <name>A0A6A7BR68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_179564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006055">
        <property type="protein sequence ID" value="KAF2857255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR68"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="101" mass="11383" checksum="20D1E1168E682867" modified="2020-06-17" version="1">MFLVSWLGPLITSSPSLPHQISPPDLPRHFRPPSPTFMAGQLWSIALLCLVSGIERSIPRSIDHVPLDYPKFTITATKLAAYLKMVQTRLRRLSEIDFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRX7</accession>
    <name>A0A6A7BRX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_260261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006021">
        <property type="protein sequence ID" value="KAF2857980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2857980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="324" mass="36101" checksum="B4AAA24AC527524D" modified="2020-06-17" version="1">MTVTARGRYGCQWTVAGQTCGCNFVSAESLDQHVVAEHVARQPHQCCWLGCEKAISFGSRPKLTRHIHSHTGHKPYICSAPGCDRGFVTKEQLKNHETTHTRAKSHVCSICARGFAVRTALTSHMNVHRGMKPYVCDECGKAFADSSNLSKHKASHRRGLRASRARRISATTLSARSSEYHKPTPSIEPESSYCELPCFDSHCPDSVRLPCRSASPCVSAPCCDSACLQLTEPCVDQVCPAMEPPCLLSDCPEANIWKCHAQNCYWGSEVWDSPCYNSTSGHDWGHMREELHQDKSDQLNRFNEFIKETINEAMTAMPLEDHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BS25</accession>
    <name>A0A6A7BS25_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">K470DRAFT_170854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006040">
        <property type="protein sequence ID" value="KAF2857499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BS25"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="81" mass="9479" checksum="2D47815C70623DD1" modified="2020-06-17" version="1">MSNSDESVRLAFVDLLTLLSRRDVTDEETKKWLKIFDENIKTQCPDFVYEVKTLYYSFSRYEEAVTVLCAQKNTRSAEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSL4</accession>
    <name>A0A6A7BSL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSL4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025383933" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9973" checksum="404476026DD31241" modified="2020-06-17" version="1">MTLDWEFTISSLLLLANCEGIFPAIYLRGPSHQLGYRTHLHSEAMVSLHWFPPQHNLLRNASNRLSICPVAEAFAGLPSTWTRKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BST0</accession>
    <name>A0A6A7BST0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_221917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006017">
        <property type="protein sequence ID" value="KAF2858132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT92</accession>
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        <name evidence="9" type="ORF">K470DRAFT_221226</name>
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    <reference evidence="9" key="1">
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                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 480.64</strain>
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    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
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        <subcellularLocation>
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            <location evidence="5">Cytoplasm</location>
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        <text evidence="5">Belongs to the RAD23 family.</text>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 480.64</strain>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858570.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="578" mass="64092" checksum="0A8832CF6044A04F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ7</accession>
    <name>A0A6A7BTZ7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_192004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
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            <end position="159"/>
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            <end position="203"/>
        </location>
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        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47654" checksum="6C9B4506AD3F927A" modified="2020-06-17" version="1" fragment="single">SSLTGHCVPPFLDESLFPSEGGFVHGRFCAPFGAGRNETSCCLPCPTTDWTYGNSLKTYNTTAGWLNVVGLIFLVFLLISYAVLPTQQTRSHYLSICLVVSVAMLELGFAIPLFANPRVCYNDITPNDMYSSTECAWGGAFVVAGGLSTALWILIRAFSMNLQICWDIVPGQKFFYASQAIGWGVAAALFTATMTATGVSFRFGASCHVNHANSLADFWGPLLAFEGAAGILQLATFIYCIHVYLKNLFLDRSHEQSNQSSGGFGNSARTAGARAVYQRLKKVLWLQWRGIAIVTICLVDVIFFAIVFVYLDGMQASVHNNFSTIEPWLLCLVHNPTERSKCLDLANEWVLDEEVVSAVLILLSITGLQVFFFLSRPALLPAWFQFLFSSSRSGNDEFVSLDARPDVMNNMGGPTPPKYAHVRGHQSTTFEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTZ8</accession>
    <name>A0A6A7BTZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3295 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_121535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
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        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="182" mass="19711" checksum="8D6B1BD46FFA9115" modified="2020-06-17" version="1">MFPPDLPPSRVHTCASFPNCHYNCSVAPTHMPPHPSSSSRLCSRSSLSHSPNMPSHSIVRGFVPGGPPSSYRSQTRLAPEPEPELSTSTRNNPPGQQPGDGKKPTMFTLGSSSGEDDGSLDRHMKSFQSNLSESIRAAKMRPQADIPEDRPVFSEDEDDSGSAIEDEDDSSGAWHCPLIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU35</accession>
    <name>A0A6A7BU35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_260058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU35"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="195"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="47163" checksum="74F8317BAC113CBB" modified="2020-06-17" version="1">MASYGEEQELDLHFGESRALSAVKAFDAFPKTKPSYTQKTRSGGVWTVFLVCASVWLSLTELHRWWRGHTSHEFSVEQGVGHDLQINLDIVVAMKCDDLRVNVLDASGDHIKAGQALKSDATRWEHWNLDRRYRRLGSSKKERAMREAGYLMDWSKIPGLEEYGGLEYREEDVHDYLSAARQGGKKFAKTPKLSRHQEPNSCRIYGSMHLNKVQGDFHITARGHGYSELAQHLEHNAFNFSHHVNELSFGPFYPSLSNPLDGILATTSDNYYKFQYYLSIVPTVYTTDAKALSRLSASNLESPSSGSDGLDKHPHRYSRKTVFTNQYAVTEQSFPVPNGAVPGIFVKFDLEPIMLTIAEEWISIPALFIRLVNVVSGVLVAGGWCFQISEWFSDYRCRRGRSNTGLGVLDGALDEKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU45</accession>
    <name>A0A6A7BU45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_283112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU45"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="552"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="625" mass="68716" checksum="C5749250A9A89589" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUA0</accession>
    <name>A0A6A7BUA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_259491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUA0"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="79"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2858774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="359" mass="39297" checksum="E8BCFCE6CC878B92" modified="2020-06-17" version="1">MSDINNPLMCLSLKDEENPSSSASSVDTVRPSSSDRATANVWSNFFAQELFLEFVDQGQKAVYHVYLTPPANPELDVLFITHHGAGTSGMSFALFAREISKILPNAGVLSLEARGHGSIVTDTYGNDIVDFSLPVMTADALRMIKLTQQNFGWSNLPNSVLVGHSLGGAICTQLAVDCALGNALVGYSNIDIVEGSAIEALQYMNTYLKTRPSAFNSVDEAINWHLSRHTLRNRESAEVSVPSLLAQANDGKWVWRTNIGATAPWWESWFKGLSKKFLQGRGAKQLILAGTDRLDKELLIGQMQGKFQLVVLPEAGHFVQEDAPEKTAQLLVEFFKRNDSSSLVLPPKISDMIAQGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUD4</accession>
    <name>A0A6A7BUD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TEA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_266338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006018">
        <property type="protein sequence ID" value="KAF2858108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUD4"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="7">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2858108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="637" mass="70540" checksum="16806B15937671DF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUE0</accession>
    <name>A0A6A7BUE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OST3/OST6 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_235574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006002">
        <property type="protein sequence ID" value="KAF2858814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUE0"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025464017" evidence="10">
        <location>
            <begin position="18"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="36257" checksum="62B8CD2FCFEE0E9A" modified="2020-06-17" version="1">MRFLRLLFAGFVSQTLAKQTPEERFQEFNSKQLSVGGPIKLNDAIYQKLVTAPRDYSVAVLLTALEPRIGCNLCSEFQPEWDMLARQWTKGDSKSEGRLVFATLDFKDGRATFQSLMLQTAPVLFLFHPTIGPNAKPDKGPSQFDFTGGTDKAEPIHAWLSRQLPNIPHPPFVRPPNYVKTAFIVTSVLGLFTFASVAGPYLLPLIQSRNLWAAVSIIAVLLFTSGHMFNHIRNVPYVAADGKGGISYFAGGFQSQFGLETQIIAAIYGILSFSAISLAVKVPRMADERAQKVAVAVWGGVMLGMYSFLLNVFRIKNQGYPFWLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUI7</accession>
    <name>A0A6A7BUI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_300639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="10">
        <location>
            <begin position="702"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1396"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1452" mass="161430" checksum="A420C649523B8A47" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUM1</accession>
    <name>A0A6A7BUM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="12" type="ORF">K470DRAFT_259573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUM1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="482"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="873"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
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        <location>
            <position position="980"/>
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        <ligand>
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            <note>catalytic</note>
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        <location>
            <position position="1037"/>
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        <ligand>
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            <note>catalytic</note>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858667.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1102" mass="122746" checksum="37E5243A4FCAF586" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7BUP6_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <name>A0A6A7BUY6_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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    </feature>
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    </feature>
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        <location>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858953.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVW9</accession>
    <name>A0A6A7BVW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_272304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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    <dbReference type="InterPro" id="IPR001680">
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    </dbReference>
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        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    </dbReference>
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        <property type="match status" value="5"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="342"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="374" mass="39662" checksum="48452F66BE561514" modified="2020-06-17" version="1">MSSTNAGYFFQTTASIAQQASKKAKVQNKLGNPITLGSKILALASPANKRAKIYTAQANGTVTSVDLTTQLGSQPILSAKAPMTCLAIGPSNEIYAGCWDGNIYSTTTTQILTTQTATKVSQEFVKTLLLLTCDKIQILLSGSADGNITIFTLENGTPTQRGKTNLNKGSLQALAVDPLSPTVEPIIFAATSSPTISMLKLKLSQMGGGYTLSSCGEFTPHETSIYAVFFTDEGDVWTASADKTAKLLLREEGWRADLSLPHPDFVRDIVVASAAGVVVTGCRDEHVRIWDQGSGALLGVYKGHYEEITSLFVTERGDEVVSGSIDGTVRTWSLDRGKVAVTMKEDIPPSAVAVGGVETTAEEDAELAALLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWE8</accession>
    <name>A0A6A7BWE8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="421671at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="293" mass="32462" checksum="1EA960F00C0253ED" modified="2020-06-17" version="1">MASSVKRLIPPDPEKVMVLRRVAPTILTCSTPFLRAGYIKIGGRGTVVQLQTGNLAVFSPVALTPTLQRELSTMGTGKVSYIAALDQEHHIFISEWHKYFPEARVLAPDTLPVYREKQGYDKLPAENWVLFKDGGMPVSPEFDAEFESVYLPEHVNKELVFCHKPTRTLIEADLMFNMPATEQFSRVTEKSGMLVNSLTRAFQYFTTTNGENPPQQRMASLIARNDPAGFSKHVKTIASWGFDRMIPCHGDVIETGGLDAFKRVFKAQLAAYPTVANGNGATPPLPDHTKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWG4</accession>
    <name>A0A6A7BWG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_265582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005998">
        <property type="protein sequence ID" value="KAF2859079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWG4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="22195" checksum="1C19E7CB8EFB945C" modified="2020-06-17" version="1">MIEQWERYRNASERMRVAWEQAGNAEPTLTEAAALQCMADAPMTFPWPAGEDDDAVMHDADMQSIHSEGNNSVSLDDGEFDECDEGDWEDIGSKDDDVTELSDYETGSPISIPPRNPHFTEPTNPWHPLDSPRDALLFAFFHSQRYSMSEEMIKAILLLCTRFIQLPGKAKIPSLKKLKKYRTRISHTECGTQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWL1</accession>
    <name>A0A6A7BWL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="8">
        <location>
            <begin position="113"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="9">
        <location>
            <begin position="331"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="893"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1511" mass="168481" checksum="7099EF64A7057F55" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX24</accession>
    <name>A0A6A7BX24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_258439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BX24"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="142" mass="16689" checksum="AA367495306381E9" modified="2020-06-17" version="1">MARKNAGPKTDMRVTVIRYHMRHPKLPRTLSFARNRHLRHWTIHRAWQLHQAKLRRARKLELERQFNSMAAACEHLRLMDGNGLTAADRTRLGVTADPGKSEGRLFRTAMQKNKIWDNVPIEYARIQTDTPPKDGWNSVWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXB0</accession>
    <name>A0A6A7BXB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_218780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005990">
        <property type="protein sequence ID" value="KAF2859627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXB0"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="17">
        <location>
            <begin position="14"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2859627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="383" mass="42305" checksum="0C8E566FE13D04AC" modified="2020-06-17" version="1">MELDHDDIKLGHVLVTGGSGFLGNHIVTLLASRKACDSITSLDLRHPSNRVSGVHYEVGDITDYDTLQSVFIKLRPDAVIHTASPHALQSSNPKTNDLYHAVNVIGTQTLLRVAQETGVKAFVYTSSASVIHDGTSDLINADETYPLMMGPKQPEYYTTTKAQAELDVLKSNNHSSKFLTCALRPSAMFGEGDMQLLPPGLSAYYRGQTKFQIGTNENLFDFTEITNVAHAHHLALAALLATHERLTSGLAAPLDHEKVDGEAFFITNDSPVYFFDFARSVWAAAGDRTKPSDVWVLSKDVGLLIAMLMEFAFWLFKLGKPNLTRGQVKYTCMTRYYNIDKAKTRLGYRPVVKLSEGIERGVRDALYRGVVVGQPPKLKGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXL7</accession>
    <name>A0A6A7BXL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_258324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXL7"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="11">
        <location>
            <begin position="192"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="64576" checksum="15073BD4568A587A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY27</accession>
    <name>A0A6A7BY27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
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    </protein>
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        <name evidence="14" type="ORF">K470DRAFT_72869</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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        </reaction>
    </comment>
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    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
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        <location>
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            <end position="334"/>
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    </feature>
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            <begin position="362"/>
            <end position="490"/>
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    </feature>
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            <begin position="128"/>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2860276.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="490" mass="53597" checksum="54F69D9598AC0B97" modified="2020-06-17" version="1">MSYSNGYGGGYGGGRSGSGYNNYDNGGSRGYGGRDSGRDYSNGRYGGSGGYGGGYGSGGYGGSGGDRMSNLGAGLKQLSWDVNSLPRFEKDFYKEAASVADRSPAEVEAFRRQHQIAVQGRDVPKPVETFDEAGFPAYVMTEVKAQGFSKPTPIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLILAPTRELAVQIQEEVSKFGKSSKIRNTCVYGGVPKGGQIRDLARGVEVCIATPGRLIDMLEAGKTNLRRVTYLVLDEADRMLDMGFEPQIRKILSQIRPDRQTCMWSATWPKEIRQLASDFQNNFIQVNIGSQDLAANHRITQIVEVCSEFEKRDRMIKHMERIMEDKSHKILIFTGTKRVADEITRFLRKDGWPALSIHGDKAQNERDWVLNEFKTGKSPIMVATDVASRGIGMITSSLPPLPFGKSLGIAPHITSIPGLSSFAFEDPWRLEWPRTHRACTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY34</accession>
    <name>A0A6A7BY34_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_80277</name>
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        </lineage>
    </organism>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="356"/>
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    </feature>
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            <end position="504"/>
        </location>
    </feature>
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            <end position="617"/>
        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="883"/>
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        <source>
            <dbReference type="EMBL" id="KAF2860131.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="196" mass="20996" checksum="F7954D10E49211D1" modified="2020-06-17" version="1">MAPPLEITSSSQLSTITRSNAYTILYFTASWCGPCKSISPIYASLSSSNTVPHLLAFAKIDTDNNRDIAQRFSVSAMPTFIALEGESKTLDTIRGADPSALKSLVERTRKLAEKKGPPGFVGKGRTLGSGTSQNAARQAPRWSTPTASPSTLVRFIGLYLWTLFSLEPRAAAAECPFAVQRQGQGSLARGRGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_282388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein MSSP-2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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    </feature>
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        <location>
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            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="532" mass="57429" checksum="59F390AD057431FF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYZ5</accession>
    <name>A0A6A7BYZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23553" checksum="537DBDF4CB5185B0" modified="2020-06-17" version="1">MFGSIPYTAIFGQIENLVKPHFAEEELAGIRSIVDDIRQQPRTGAREAAWRIFQILVDFGLQDGLNDDDLQEQLTWIGILGPHPDVRRKSQEVMLNWSIVDKNNVKLKRFAQLFSRIPLERRVVNPDAARQPSQQGELSPQGATHTGTAQHGAVQAGAVQQGAAQTVTTPIGIAQQGTAQQGAVQQGTARRREARLRAALLGFLHRANYCAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZP8</accession>
    <name>A0A6A7BZP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_216428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="177" mass="19317" checksum="05C4376FFEF5816F" modified="2020-06-17" version="1">MDTKPYHIIAYGTLLGSSVFQTFIGGPLAFKALPRAQFSTLQQAIFPTFFSLQTALPILLALTWPGERVASMGQVAARYNVGYKGLLENNKALGTIGIMFGTALLNLVVLGPATTKVMKERKHQETRDGKRYYDPGPHSEEMEHLNSAFSKLHGASSLTDVVGLGAMVFYAFIMSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C037</accession>
    <name>A0A6A7C037_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">K470DRAFT_192476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="46"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="50"/>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="657" mass="71125" checksum="79F5989785D9C08D" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0C2</accession>
    <name>A0A6A7C0C2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Vegetative cell wall protein gp1</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_281775</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <recommendedName>
            <fullName evidence="5">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_257201</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LOR"/>
    </dbReference>
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        <property type="entry name" value="LOR_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04525">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25103" checksum="00438CC558103290" modified="2020-06-17" version="1">MGTRLPSFDTTSNFSNAETIVPDQAHPRLGPQPDKPNIYSPTQSTLSITNLAPLTFTAQTPDGQVICTTQNSRSLLHQRLKFLNAHRSELFTIETVLMTNKNEFRGFSPGGYDFYITRARAITREGIQSTVSFRNASDGKRVELNIRTNWAGSLSHVTYAGSIVAEINPCFIPDTHTVTVAPNVDLSLMAALCICFCKWQGVPARNGASSGGFGMGYVSAAYGGGGFAGGDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C176</accession>
    <name>A0A6A7C176_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C176"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42240" checksum="07F0DDA5534545F6" modified="2020-06-17" version="1">MYQRRPAARSGAGSSRITPPQRKVVNCIADDTALVAGIKSTTRNGIRQWVARGHMRLFVPLHAIQQLQRQKTIGPHSRDADDTLTWLDDAITRYPWAVALQGGDDHYESWADVERYAVPRPLLSETDANGSGPRVSTSLPSPPTSPVQQPAASPPRTTTPVSLRPLFNYIIWRVHQEANLVAALDSFIFLCNDEHKVKVAKGFDVKCKRLEELREAINREEREHGVGDTVQPEQVTADESDNDEDDDDENDEEIILFKPRNCQNALMDPNDFDRTTRSPAVNPRGDVRHATSRRGARPITPRGNARPVTPRGGCRGGGRGDFHKSPRGRGTGGRGGNRGGGFDFRRNRIVTNNGRVANAGQVDPDSFSRPKGGATAGKLWEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1A8</accession>
    <name>A0A6A7C1A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005976">
        <property type="protein sequence ID" value="KAF2861017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1A8"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="97" mass="11475" checksum="43A3FA731CF92674" modified="2020-06-17" version="1">MPAPPEEPPLYIRIKVSWDGVTRYVLIMRGTDFREVKKLIRERFNKPRRTPCLMKIQDPDGDKITVSDDSDWLLAVDWFQQIIAENFGQLKVWVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1L9</accession>
    <name>A0A6A7C1L9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_270174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1L9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="269" mass="30358" checksum="4EF026EB922D6AEA" modified="2020-06-17" version="1">MSFRYDRFHFCSPIHGISLHHPPGRGNHGLKIVKIRLQVQGGGSRLLEILKIHLHVQEEWKKLAAGRRRVRATTVVHTHVYSSRCEDYDAPLFIGSNGSTKYILEPTISYLNAGGEHPSLKSSQIYTTLLAVGDTLPTITLSNDTLPTITLSNDTLYLTGITLFILMSLFLGTLIGQKIKPHDEIADMRMQIKPSQPKTKALSNQLDAEKRRGDSLTRRYNELRATMAEMEEVQRRENIKVLFGKIEDTIGRLREYVQDSYEEEEGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1Y1</accession>
    <name>A0A6A7C1Y1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_216585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Y1"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2860698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="327" mass="36519" checksum="BA95B0A177CEDB22" modified="2020-06-17" version="1">MEAFVPRLAFPVLESLPRSYYLGHHAAGLAKMRSLLGSINLVIECRDSRVPLTSHNPLFEQSLGEREHIIVYTKKDLCPVISPQLPLLRRFHFPSELLCCDHRSPGDVRRVMSHIKRERTGDLAGLRVMVVGMPNVGKSSLLNALRAQGMGRGKAARTGAQPGITRKIGTGVKILDSKDRSETVYLIDTPGVFMPYVPNMEAMLRLALCGCVKDAVIQPLTLADYLLFHMNKHDPKLYGDYASPTNDVAMLLDGVARRAFPLKKGGEPDLNGAAMWIIQRWRNGLLGSFGLDEVSDASWQALVESREAQSFSKSRREWMKRRRQGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C200</accession>
    <name>A0A6A7C200_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_281997</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C200"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="356"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="768"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2860718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="821" mass="90631" checksum="67F9A5300016698F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C243</accession>
    <name>A0A6A7C243_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_281884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C243"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2860768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="35469" checksum="E2B57768D5420701" modified="2020-06-17" version="1">MARSTARSRHTSLPAYLRLPLACVINVVIGIIFHSVSAGITGYELAAISQRPSDYQLGLLMAWKLTEGLLTYVLGYHGKSKDVAALTCLGHLPYYFFLYTFYEVDTKACGLSLAVDVGRLALPSLLMPPADRPRTSDGEDRNLTKNASDWLLTIIFGATIYALVIYISFSTWLLPYLVTHFDHMRSLEKAHNASITALTGLLLPLGWASSQYLFAPTVANIEPLDDLQDMAEFDPATASLQETLAHNLGIDKHGFSNRAKALTLRAVVLVAYSAINIFIRVFFTVRGAEPLGTLAWAGMWGAAGALTSLAYAWVGHRVGLNETGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C244</accession>
    <name>A0A6A7C244_9PEZI</name>
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    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="195" mass="21557" checksum="0DA9DD1840C1A2E6" modified="2020-06-17" version="1">MEHVRNELASWWAPHPDVPVASHAPQIGSPAPHTPKLGLEPGQPTVLVFLRHCGCPFAEKTYLNLREVARRHLGVAFIAISHSDERSTTAWLKSLPQVGSETPNVRVVVDARLEIYSAWGLGQAPYAHVLSPASLFEVWRLARDEGIVNRPTDSGSRWQMSGFFAVDKDGIVRWGRPAKRADEIPDFEAAVRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17133" checksum="6595ACB6602245DC" modified="2020-06-17" version="1">MPDTSVPPRERLGAMPFNQLQTGLHPPERPPDVLLEETSISPRHRTVQLHPSDIHPHPQQVIAPPTHQFLGLRRSFPQHEHDRPSRAKPPSKRPMNGCQENLHPLRNIQHREKEGNCSLSTAQNHPGRAEIVPAGNEGLSLPCWRMSLTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2B5</accession>
    <name>A0A6A7C2B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
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            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="12" type="ORF">K470DRAFT_257223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2B5"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2861075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="743" mass="85877" checksum="5AEDC3C8C3C0E028" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2C3</accession>
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            <fullName evidence="3">MFS maltose permease</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
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    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55937" checksum="034F162DAEC5894D" modified="2020-06-17" version="1">MLPRPVFGPLRSSLVYRRFSRVPALESSWGIRPSVKKGLWLGLRWTAIAYTFVALGSLAYMGVEFMHEEQERPTPEEWKVLTKWSLRNARKLMKAVDDGQLTIEWPLVAKYLRYCLLRLEDPKCDGKGIVKLEEGLDVSTKSWPWKAGYFEVIMACAVAAEHLDSSVIDTKSLHVFPKAMVIGHSNPDPIPTPIFMPPAPREEDCVRVFDPPEVFYKRVLATKGFTTEQKLEAALAYANWMERQGQPMDATELHEWAIDLAKNSRSPETDALNGENKMSSNLLRATAALGMHQARVGNPSVALPILLSALQARRSATSPLPQLATGSARCANGTTDSNGVVQWLHRALTPPTFPPPPPSGDAPLAPRDHLTCEDSELMLYIAQIWPSATEALDWARQGVTTAKNCLQFDKDSQSKAEQLRCLQCLEKGAGMWKLGLHNQITGQTQSNNWLGWLWQRPDGKEKEMVQEMKDVDDLLRQAREWKPGFGGANRNLVAGSTLTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C2G9_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2861135.1"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="62" mass="7019" checksum="029FC0B4AD21C371" modified="2020-06-17" version="1">MKYQEAEDEDNCSYNESDWDSEDDGTIIRDASDISESAHEDKDGEFPTINEMSDVQTSVPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2R2</accession>
    <name>A0A6A7C2R2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
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    </protein>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="464" mass="53612" checksum="C74C2B39C8A98C23" modified="2020-06-17" version="1">MSDDDDFMQASDEEDYDFEYEDDDAGMQDGDVDVENKYYNAKQMKADEPEEAIEEFLGVLALEEEKGDWGFKGLKQAIKLEFKLGRYTKAVEHYAELLTYVKSAVTRNYAEKSINNMLDFLEKHAEGNAAHECMEEFYKRTLESFQASNNERLWLSTNTKLARLWLAQKDYTRLTNKCRELHLACQRPDGSDDASKGTYSLETYALEIQMYAATRNNKRLKGLYERALRVRSAVPHPNIMGVIRECGGKMYMSEENWKEAQSDFFESFRNYDEAGSLQRIQVLKYLVLTTMLMGSNINPFESQETKPYRNDKRITAMTELVEAYQQEDVRRYEAVLASNPDLLADPFIAENIDEVTRNMRTKAVARLVAPYSRFRLDVIAQRLHISEAEVQDIVAFLIMDGRLRGLIQQGDGRVEIEERDGEERLAAVSQWTESVRGLARAVLDSNFFTTSDEPEMGSMRRMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2X8</accession>
    <name>A0A6A7C2X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35Ae</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_275739</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C2X8"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="12653" checksum="19487D84F2325C05" modified="2020-06-17" version="1">MGSEKTASGHRLYVKGKHVSYQRGKRNTNPGTSLLLIEGVHDRKDTAFYLGKRVAYVYRAKKEIRGTKIRVIWGKITRPHGNAGMVRAQFKHNLPPKSFGGMVRIMLYPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C315</accession>
    <name>A0A6A7C315_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_25381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C315"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="192" mass="20981" checksum="4780A7B66019EE44" modified="2020-06-17" version="1">MGNYKWAWERTAKLPHRLIRVAMNQARDRRATPRGPSSFLVGHRRCGWAFPVRSYHYSASAPPRIPSLQPDKPPLHLPRAQATYSSVQNYAIRSASSPGFLAAKIRASLPTPVCTLRHLPSMETPGSPRTAPAAGALASAASETTGPKKERCNARVPHCAAAASAHGKDERKFPPSTTRRWADVCGPRSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3D7</accession>
    <name>A0A6A7C3D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3D7"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="362" mass="39346" checksum="2BEA88800B829D65" modified="2020-06-17" version="1">MPKRRRERDRPKAHPNTGYNPSKRVLLKYGSSSPSSEGEVTSPPDAKELVNYNIEEYPSSPSAEDEGDSINKIGGEGLGDGDDAEEGAKYCDGEGDQDADKEGKFIPPPPKPLRDRLTGQIPALASPLSDDEDEEDEAVQYLLSVKRERDALPLVLRLPEGGLPANELPRGRLPENGLPDSQPHLEEDLPEEELPNAKATRPDAHPSPEDEQEDRASAKEAFKTRILSLFARARNHTATVSAGRVCEELSAIFSPDETPEGKCHEGALPSPFSNHHSEDGGDEYPAQDGLNPAKIWGLLLLIDPARLIPDDTFSLRQVAKRAGNLGREAGEEVRAVCDVTIIVVGEVCGQRDLLGLRGGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3E9</accession>
    <name>A0A6A7C3E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3E9"/>
    <dbReference type="OrthoDB" id="977966at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45682" checksum="7074E4ACA4F29C60" modified="2020-06-17" version="1">MFENVFLHKDFRATTATELIDEKFIRQFLDLMNQPSQQVRLALTKALHQLYRYVVPRRQLIRRCMSEIISQYLCGEPYSHAIPNFLTFRGMNIRNEQLFMASEYRPFFKNILIPLFKKCEYLHLFEPYLISCIGEHIIREPQLAVTLIEALIRNWPKTDSQLQCSHLVQLRKAITGLRMGNECLFERLCTTVANCISGDRTEVVSRALDLATDIAFRSHLKKNIDELIPIIASAIKTAEKHWDVSTRILASGAYASLQSTFPETFDSLAQKQEDMTKNKFANEVARRIRWERISKLAERNLSRMGESECSLSSVGDGIKQEGGSRLQSPAREHPAEFAFPDDCSDGMKKDIIKPNSNGQQEASAMLNDVNGHEDIDMTDLSMPSNFVMNEENLYDQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3I2</accession>
    <name>A0A6A7C3I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_256307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3I2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="89" mass="10598" checksum="0FCBEE5A0B5BE025" modified="2020-06-17" version="1">MSIEEHMLRLMTHGANYTILEPCEKGIRSVVMRMEPFRNEKFNRTVRGNSNYEPSMKSRVRTPIIHTKSHTLRTRTAARRWSYNHPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3V5</accession>
    <name>A0A6A7C3V5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_245138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3V5"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2861645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="532" mass="58123" checksum="A096875BD1A92069" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3X7</accession>
    <name>A0A6A7C3X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_256478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3X7"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="370" mass="40986" checksum="2A7E68EF4B1065BD" modified="2020-06-17" version="1">MAQKRKRDSDNPHDGSDANRGAKSMGRVPPYRPLNTQGGFPPVKYFPPELPTIQDPDLAVLPFRHKSLTQDYNRSIPTGQTYDDLEFLGDAQIELMASRLLVARYPNVLAGHKSQLRELLVKNETLAEFAKMYNFDSRIPALNQGKAFAGVSKGGKGNKGFLKVMADMFEAYVAAVVLDGGDEGFEIAERWLTELWGRKLCRVMGDYPGLTPVGRDNCSAAVEHTFSAAVGEDSCPAAVEHTNPTALSDHPCSNDSPLRTFDHKAKQTLQRRILSGPGVRLVYKPYKPAEELKGDRIGQNRHFIGVYLTGFGYTDFELGRGEGRNKTEAGCWAAIRAMWGEHKHVVDACAAKVEGYRERLRREREGDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C411</accession>
    <name>A0A6A7C411_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_299172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C411"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="565" mass="64028" checksum="FE18713730CED5B0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A0</accession>
    <name>A0A6A7C4A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_22778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="252" mass="28685" checksum="7BACCD54971641E2" modified="2020-06-17" version="1">MTKLLQDDSTDYTSSTDTVASKNKQRLNPDSGSAERQAEREVFAQEDPVKYTNKALADDAHNEVGGEKGPTRARVGSSINHAPRRQLGAPSSKIDPPKWSRSSVATSFRVPTFAQCQTRASTSIPERYRPVARRQLRGRYSAGKPSTIRRATESQVIPSRHSRRRRLPPQRVARACRGLEDNMSDFHQNMKEVYAQMREVFSPRADRLADACRQDYETFSHARRWHEACDWVERWAPQDFYPVPAPENPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A6</accession>
    <name>A0A6A7C4A6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_256332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A6"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2862072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="412" mass="47196" checksum="D5ED046AC4818F8C" modified="2020-06-17" version="1">MAGQAVSLYLARAVPIFLGLIVAYVTYVLIGPLSINYLLNPPEGRVRRGPAGLAIPIVWAILLFPLIVTWLRLLTVLYGDPGYVKIQDGKDPPQDFWTRDVFVCDILGRPLWCEACQTWKPDRAHHSRDAGRCILKMDHFCPWVGGVVAERSYNFFVQFLGWAMLLSAYDVAILGYFVHEDHSHPHWFVALSLGAFFCFFTIGMVINNLWLIANNATSIENLSRRSRRMFLAVALPPELQNISERPRTSDFTSEIDDPAHSRYGREGNWPMRRLAKSEYWKGTVSYPLTPPTDRPPLPAANPRVFAIIETPPGLNPWDLGSARRNFSSVFGANVHRWLFPFRHSPCCDHSSRVSFYPMGPQFEELLEQVGLVRREETRAPEQRPVLSEGWRNGERPDSWWIGKELRRMERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4A8</accession>
    <name>A0A6A7C4A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_281350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4A8"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="21"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="547" mass="60201" checksum="65AC89147843BE23" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4E6</accession>
    <name>A0A6A7C4E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_23604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4E6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="99" mass="10997" checksum="693196B1768C9039" modified="2020-06-17" version="1">MAMRNLLSATFRCLFSTYAFRDSLINSIINNHEGIESFLIRCPANMSTKRCSTNNVESQGLTVDSTELDILSVLDNTNHGSKTFSSLQLNEESLCEGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4U1</accession>
    <name>A0A6A7C4U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_281266</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4U1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2863031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6A4"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="746" mass="84059" checksum="89F80C6F44549A60" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_262265</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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            <end position="114"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="114" mass="12145" checksum="EB95896453858558" modified="2020-06-17" version="1">MATTIILAEIGTAPWAIIGQERKTAQQAWFIALLGALCLAGGLAVQAGDGQVSECRANHGHVAPHAVGELHGHRAPSNDLKLPRRSTSVPRSFEPLQVGFDRNPFPRHGHATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6P6</accession>
    <name>A0A6A7C6P6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Ras small GTPase</fullName>
        </submittedName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2863246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="152" mass="17475" checksum="23A8953C6824661C" modified="2020-06-17" version="1">MEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREEQEEISMQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLSKAFDLRCTIPEIENVGEPLLLYQSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7D1</accession>
    <name>A0A6A7C7D1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_255188</name>
    </gene>
    <organism evidence="13 14">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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                <person name="Goodwin S."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C820"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14311" checksum="10EEA1861F45DFB3" modified="2020-06-17" version="1">MATLKYAAAKALGLTPVEAANNRFVALSVYRDVLRATRIAFSGMPIPPTLAQQTFAENKGLGSGTEDALKAIQHAEGVAQILRENVVQGKNKGQDTYKLRIHEHTQRLDNDTAKQLKGTSKSFAEIKKSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8A7</accession>
    <name>A0A6A7C8A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_254697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8A7"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="66" mass="7383" checksum="A959378EF194213A" modified="2020-06-17" version="1">MNSEVLPHNVARLEADLSALNQEHEKTLSVNKQLGRQKADLTVHVTDIQSHIVETSEAVKKSNCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8B3</accession>
    <name>A0A6A7C8B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_268095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8B3"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39853" checksum="03974C88D3582413" modified="2020-06-17" version="1">MSATPVEWAISPCVGNSDGHELRKAVEGYLTQAKPGVDESTASGAQGRRSSTTSTVRYRSNHEPFKTFQDKVWARTESVGAFESIWLLDRAIEGIYRIPRPGEKPSGDCKLKEALTREIQDQVAVLQLRTRREIAAPKLFAFDAGRKNPLHCRYTLTKRSPATCLEDVFDSMALPERLDDANGLVQFLLATEHVSFPHTSTLTASRQPDMAVKGLTPQDGETAETLADLLPRMLKAHVEGRFTEGRGLWAPYPVLHNMYGISKEMKECGIFDLRHRASMSTSSSIPRHRDLFPRNILVARPSPHQAWKIDLVADRNEAQAVPAVLIRRPPCCLWDRTDKDKMAHVRSDAIGDEDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8J9</accession>
    <name>A0A6A7C8J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_293134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8J9"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="225"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2862958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="381" mass="42497" checksum="7CCEE6B710F6727A" modified="2020-06-17" version="1">MALRRACPRGTAKQHKHARTHISTKTTQNTNANRNLRRYSIPLPLSQSTNPPSGVCAGKNSVKQHLLSKHDFIELKLTTQHTPEVEISDTTPHVYPTKEFPSISSLLDFALKNWQSNFVTSSIYDEATVDQLSQRPFFILIYIDAPITLRWERFRDCCHRASRPAPTLEEFVLKNDERLYSPMTGIAGLESRAGIKLLNATSSVERLYAVLDGVDLLDQRRLRPTWDQYFMKLAGLAARRSNCMRRQVGCVIVREKRVISTGYNGTPRNVRNCNEGGCERCNSGGGGGAALSTCLCIHAEENALLEAGRERIGGGAVLYCNTCPCLTCTIKIVQAGITEVVYSQSYYMDADAARIFKEAKVQLRQFLPPAEGLVKLLDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8K9</accession>
    <name>A0A6A7C8K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_298061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8K9"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="302"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="511" mass="55867" checksum="F22001A68C9DA3B7" modified="2020-06-17" version="1">MGNQASSSRGQSGSQTPTGIEGPPLGRSDTRESTRSFKSALRKIPGKSSDSIRSAVGDVMGSSATGNRDSSVGADDARRVGRTARSSSEPGPLGEDDKNTPRLPPSPTQSASVLGPHGDLAAAQRRGEVDAVSETPPSALSRPSTATSEPSESILMKKKPDATPATSGIASLSLADSSSLDLALKHDDLDEYIRRLLDAGYTAKTPKQVCLKNAEITAICHAAKEIFLSQPALLELRPAVKIVGDVHGQYGDLIRMFEMCGFPPSSNYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNVRVWKTFVDTFNTLPIAAIVAGKIFCVHGGLSPSLTHMDDIRNIARPTDVPDYGLLNDLLWSDPSEANEADWEANERGVSYCFNKKVIIEFLQKFDFDLVCRAHMVVEDGYEFFNDRLLVTVFSAPNYCGEFDNWGAVMSVNDDLLCSFELLKPLDSSALKSHIKKGRNKRLVNSPPASHIPQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8L1</accession>
    <name>A0A6A7C8L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nnf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_241364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8L1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21553" checksum="9634826C0ABC851C" modified="2020-06-17" version="1">MSSPPVAQPAQPKPGSRESSLRSLYDKAITYILTHTFTLEALETSFPTIASYTPQALANLHAQLVGNLEQQLKDHFEVILQERNVPTWLAQLDRVVEEARRRKGEDEGGVVPTALHALPAEELVKARVQPVLSGCEEELDRRFGVLEERVRERFERVEKKGGEVEVLMKRIEGAFERARELGEVGEAVSEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8M6</accession>
    <name>A0A6A7C8M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8M6"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2863926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="330" mass="37864" checksum="877D7199C0D32406" modified="2020-06-17" version="1">MVEVVQPRAYVGFDSITTQIQHKLVKRGFQLNVMCVGPTGLGKSTLINTLFASQLAKSHGRLEAQEAIRQTTDISLTSHVIEENGVTLRLNIVDTPGFGDHVNNDRCWEPITRYIKDQHSTYLRKELSAHRDRHIPDTRIHCCLYFISPTGHSLKPIDIVVLKKLCETVNVVPVIAKSDGLTIEERQLFKDRIREEFAFHNIRLYPYESDEYNSEEVAMHAQIKAILPFAVVGSEKTMEVDGQLVRGRKHRFGIVNVEDENHCEFVYLRDFLIRTHLHDLIETTSHIHYESYRSKQLHSLRENNSGGNRPMSPATDREMSRHSQHGVNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8M8</accession>
    <name>A0A6A7C8M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_204257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8M8"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="89" mass="10210" checksum="17A0189E9EFA49FA" modified="2020-06-17" version="1" fragment="single">MKITYESYTSVAEWKWDLPPDSDDTCGICRVQFEGTCARCKYPGDDCPIMMGTCTHCFHMHCITVWLSDESSQGKCPMCRQPFREKVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8P4</accession>
    <name>A0A6A7C8P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_240871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005959">
        <property type="protein sequence ID" value="KAF2863891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8P4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2863891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="22931" checksum="DA7FEFD52166498C" modified="2020-06-17" version="1">MPVKKVRGQKAAPAAPAADDEEEAKPATKTGRGKKAANKDTSDDENEEQQEEPKAPAKKGGRPKKAVAENASSEEKAAAPAKKKGRPKKVVVEEKAVEDGKASSEEEVPTKEGAAKQAATSEPELPAKEEASPAAEDAPEDKAKGKRASSADGEEENENPTKKQRKAPAGRKPKAEPANDEAEAAPVKKARGRPKKAVAEGAEVPKRLPRGKKAAASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8W5</accession>
    <name>A0A6A7C8W5_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">DUF590-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">K470DRAFT_209845</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2863880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="171"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="661"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2863880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="731" mass="83924" checksum="28C24B7D660BE750" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8W6</accession>
    <name>A0A6A7C8W6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_279847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="112" mass="11411" checksum="0DF006D23976018E" modified="2020-06-17" version="1">MSTAELATSYAALILADDGVDITADKLNSLIQAAGVQDVEPIWCTLFAKALEGKDIKELLLNVGSGGGAAAPAAGAAPAAGGEAAAPAEEKKKEKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C984</accession>
    <name>A0A6A7C984_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRO1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_297601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
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        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="774" mass="86858" checksum="531B010D1B58C9AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9E5</accession>
    <name>A0A6A7C9E5_9PEZI</name>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_225819</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="131" mass="14519" checksum="41B9180242D3D389" modified="2020-06-17" version="1">MAHRIISQVVFTGARVVGKAFAEAYKQAASSQRHAAANGSGGSGSLGSSRLTLVEACKILDVAPPKDKTPFNIDAVHSKFKRLYDLNDPKKGGSFYLQSKVLRARERIEMEVREAAQDAEERAWRPRLYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9W5</accession>
    <name>A0A6A7C9W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_201388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="440" mass="48750" checksum="3474DC9E15E29F0E" modified="2020-06-17" version="1" fragment="single">QKCWICFSSPGENEPSLGPWRSPCPCALVAHENCLLDWIADMEADRKRRDRGIKCPQCRAEIKLQGERDVLVEGMKVGDRLAARLVLPLVGLGFAAAVWKVSTAYGVQAVYAVFGYNEGREVVGHMLLDAVRPNLLGEWAFGGDVYGGGGFAEGVMPILLDHLSNWRTHLAIPLIAPALILSRTHLIDSVLPVLPIIFFVGKSPTRWPPSPALAFAMLPYLRSAYNIYWSRIWAEREKRWVADALPRGRDANANEVEIEVDAVLDEILGADDEGEDDIFQVQVRGAEFPIIDIWGEGNGEANVDEEEDEGMPQPDVQQNRAEPRGAPVEVPEQERWDPLAPVQVPQDRRMTFSTTAIAEHVLGALLLPTVAGLSGEVLRLALPAAWATKPAGSAARGLLQHKWGRSLVGGCLFIMVKDAVWLYVKWKMASMHKRRRVMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAF8</accession>
    <name>A0A6A7CAF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_280000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAF8"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="101"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="12">
        <location>
            <begin position="260"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2864247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="757" mass="86601" checksum="48D0A3D09E59DC51" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAG1</accession>
    <name>A0A6A7CAG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_254046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAG1"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2864393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="226" mass="26438" checksum="0C2E7C8F402E8864" modified="2020-06-17" version="1">MADKDKKPDEFFYTWANFFSILTGRASSQTRDGYFHARDVAREQLDCARCEKDKRWLFAYSPMIRFMKHNIDLLGPADGSASIHPGNVRCRRCETHQSGGFDPNYGILICANHLRNRGHLEDTLAHEMVHAYDYLRFRLDTQDLRHAACMEIRASTLSGECRWTREFFTRGQWNITQQLQECVRRRAILSVAARPACKDTEQATRVVNEVWDSCFNDTRPFDEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CAJ1</accession>
    <name>A0A6A7CAJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_279901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CAJ1"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="363" mass="40319" checksum="6DB6407375F4D4F3" modified="2020-06-17" version="1">MGVEEVCEAFATNDGAAAAVAYSIMTVANICTHQTMKACTEKVLNYTTTFERSLTLGLFLVKLATELLVTEPPTSPNHYTHAGLITEQDKLPCPEYRRLHLVYIVNDTFCAVETHLRAAPDAQKTVQYDTTRTLLKQIAPLLINVAALQTTDDVDTTDSLRAMLPIWQSLDLLTAEQTATQTTTLQTTNTNHQTPQTLTKATLQNLTILESTLKVIHSKASLTLPLRHSNPHDPSAPWHALPAANGLYMLRTRGYPLRTYAFPAGGYQLRNGGQPPPPPLQNETKALHTEMLQCFSNPTSVDDISDIDELGNVHWKDPNRKTRNYWGFAVDEIERVESILEGFGGKGMGYDDLGERRRFGRRG</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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        </reaction>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="325" mass="37069" checksum="37106F71BA23698D" modified="2020-06-17" version="1">MEYSIITPSIKSTEKIEDRTAPLTKVSKKTQRRQLKRLRAKRPSQAPTPLDLPAELLHDILTHLTPSEVLRARCLSRNFNAFISSNESSLARSVIRKKYRVLSQSFPLPQPLSALDEESLQALRRPGRKSLLTDYQKGFTHIPSPPGDKICTCPSCIMAWNNLATVLDLHHWQSNLNAREPIPMIPRGQNPVWNVALLARSAAMVEKAIQGHLLTYALILERHLNTIIGGLTRHGNRTPARTPKSTAYPKVLYGMTAADVESGTDEFLEREGRENYEIPYTRDNYYNNNMLAYVPNRKWDKKNESWIYFAVSAHERDLAWLKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQ61</accession>
    <name>A0A6A7BQ61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006043">
        <property type="protein sequence ID" value="KAF2857441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQ61"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2857441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="149" mass="17529" checksum="3DFDB00FE7F8E452" modified="2020-06-17" version="1">MGKDLMIPRQVVWPQTGPREEENGTDQLNHPSFNFYWGDSINLPHTLPVLARLRSRNWHRSVRSSRRLHRSNHYYKRLVWLCCCPSDQARRVLQTEHVETASQSHPGRQQLLDVHYNTDWIRPRSHFQDDNEHATSNVTLASWTGVTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQK1</accession>
    <name>A0A6A7BQK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_194574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006039">
        <property type="protein sequence ID" value="KAF2857533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQK1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="255"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="474" mass="51712" checksum="62AD4631B7845EFE" modified="2020-06-17" version="1" fragment="single">AATDAPTPIIAGPANDAAVAPSVTQNAPSKTLEERGLGDMFSSVGHLLGSGIPSYVVSGVPNFFQNLPTGDAVKSALGLKNSDLDALPTQVLNIDPYANWTDQGWNVRFHGNVYKQPNTSKEELTKRADDLFIYGTSMKDLPEDQQDQARNVTASIFVVQQGNVKVAPINLEPAPSQGSSGQPGGGGATTPSGGSQQIVLPYNTTIEGDFDVFMPIKSNGLIAGNSTRSVQRLNTYVQGASIGNSTAYLVPTEGITVVSDIDDILRVTKIYQPKIGLLNSFARPYLKWKNMPSIYSNWSRSLDNIHFHYLTTTPEQVTRNYMQFIYSTYPGGSFDTRPLNFSDVSATLSIRQFLLIKVIQSFPKRKFVLVADTTNSDVMKAYPLMAKTFPNVQCIFLRNTSATDPDNHFPYDTSGFKDIPQSKYLFFRTPDDLMNLDLAKGECYNRSVPQNLTFGWQNLPLGLSSNGAVNGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQL0</accession>
    <name>A0A6A7BQL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_223129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006037">
        <property type="protein sequence ID" value="KAF2857561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQL0"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="424" mass="47599" checksum="CF12F59F65681942" modified="2020-06-17" version="1">MAKRKSSPSRLATGELPARTVVFDNGSWTIKTDFPTAVPNCIARSDRDKRTYVGRELADDCGDYGALRIRRPMERGYVINWEGEKAVWERTLSELGVHNEEDVTLIWTEAPNATAGLQKNADEMIFEEFGFGASWRTIAPVLNAFAPSAFPEESTECLLVVDVGHAHTTVTPLYHGRSFPTAIRRLDIGGKTLTNQLKELISRTFDVHKEDWIVNEIKEDVCYVTQNFNQDLEKCWAHGPHKRDPSIVVDYVLPDYETIKRGFSRPHDPKLNLRNAALGIGTEGGRREHILTIGNERFVVPELLFCPSDVGMAQEGIPGTIMQSLNSLPAGLKQAFLANILVVGGTSLLPGFMERLEAELRSIVDVDLEIRIARAEDPVRNAWKGGFQLSQNPDVLRKHVVTKQEYEEFGGAWTRKVFEGRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR10</accession>
    <name>A0A6A7BR10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_222888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="MU006032">
        <property type="protein sequence ID" value="KAF2857683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR10"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="231"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2857683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="575" mass="64667" checksum="283F7FC010D271DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR40</accession>
    <name>A0A6A7BR40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">K470DRAFT_237828</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006029">
        <property type="protein sequence ID" value="KAF2857731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR40"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="37"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="294"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2857731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="439" mass="51365" checksum="A1DDBCA6C39CDA92" modified="2020-06-17" version="1">MDYNPRSSMFNARTSMARSSSQFQRQQQQPRKEDDGNAFMTLPDKEIAGCICDIGFNFTVDDLRKPNPQQVQKLFEWFLVILTGTTREVVAPAMHEAAIEHCGEDMADRVFPPEARELAGFFVTLRTVLSECGVKDFSTSDVYRPTHGRLVKTFSYLINFIRFREGLTDILDAQYAASGKTKADIEWLSQENQYNEETLRELQENRKNVEKTLKEKEQRSMELKTRLLELKKVQEGVSEKLEQIKGEQNRLKHLLEQKTMAILNQKAEANRIRPYTEQSPAKLEESLQELGSLLTREREEIDQMEKRTRDLQLSLDSFTSVHTDISHLLTLLEQIQSEQAKEKQEAHVGARNREALAEKINNVRELERQEKLTRKQLEQLQKRTEKIRSDTEAKSAAAKERMEELRKEHRELIEQRRGRGEEVERRRIRIEQTEKKVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR76</accession>
    <name>A0A6A7BR76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">K470DRAFT_301247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="MU006030">
        <property type="protein sequence ID" value="KAF2857714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR76"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2857714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="280" mass="30726" checksum="9A88A566DFB15AA0" modified="2020-06-17" version="1">MSRRPPAAHPPLSPSIHYLSPQTTHFGFTTLPLSEKSSRVASVFTSVASNYDTMNDLMSLGIHRLWKDYFVRSLRPGSGGGQTLLDIAGGTGDIAMRLLDYATEIKGDAKTKVVVSDINPAMLDEGRRRFAGGRYMTDGRVSFLEANAEDLHQVGSGTVDLYTVAFGIRNFTDKDAALREAFRVLKPGGVFACLEFTPRLSWGALNAVYKRWSFGVIPIIGEVVAGDRGSYQYLVESIERFPDQETFAKMVEAAGFVLPGRRWEDLSFGVAAIHKGIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BR82</accession>
    <name>A0A6A7BR82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_283641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BR82"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2857766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="343" mass="35701" checksum="3DFFAB7999939383" modified="2020-06-17" version="1">MSLKTPLCPLLGITHPILLAGMAHVSTAPLAASVSNAGGLGVLGGLDYTPAQLRSMIRDLKSLLHSPTLPFGIDLALPQIGGSARKTNHDYTNNTLPELIQIIIDEGAKLFVSAVGVPPPWAVEKLHAAGVLVMNMVGHPKHALKALRGGCDLICAQGGEGGGHTGRVATAILVPAVVDCVRGCTSPLTGGPVLCVAAGGVYDGRGVAAMLAYGAAGVWVGTRFLASEEAGCSRLHKDAVLTAGLEDTGRTLVVSGRPLRVRKNEWVRGWEETGLVEGLCAQGIVPLEKDLEEGREVDVPFLMGQVAGVIHEVKPAGMIVEEMVREAVEVLRQLGGRTRGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRI9</accession>
    <name>A0A6A7BRI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_222534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BRI9"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="474"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2857851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="688" mass="76245" checksum="723E64F13F975BB8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BRQ7</accession>
    <name>A0A6A7BRQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_296997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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    <sequence length="451" mass="48314" checksum="6B0057BDF3BC6B4B" modified="2020-06-17" version="1">MVRNPDFSFPPRRPASVHTHAPPVLRPSIVLSHTRAASALPNFTFNASDASGLCDDVSELNSDAVAPSTPSHRGHRRNGSEFVGGDSRQGLGHSISSSPLKRPAAVSSLSAPLLSGRGHAHRRSAALDGGDMIVVPLIGNRKSVSLPSSPVVPPPGGPDTDTQPEPPVSPPTRARVGFSENVEYIPRPLSITSSDTGSSFSSPRHHSVSNSISSVLSLNTSSSPAARVPPALLSEASAVSVPLRSPRAHLSRRLSDPDTEKARSPPTTRELSTYPQSNRTYRTNVGKRNATQAGGSSFHGAANQDPFGPTPNRHSYTPCTTSAATGASVFDEDEKCYMIDLDWAVCPAELAEHRPRRELHSSRLNCDFSGPGQHFQPRLHRRSESAPALPMTSFRGISSQCSLADVFEGEALAAPALPKPCDYAPQRLLWPISRRRVRPVTATVPRLRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSQ0</accession>
    <name>A0A6A7BSQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_260068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006015">
        <property type="protein sequence ID" value="KAF2858234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSQ0"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="7730" checksum="631ADF6B16BEC0BB" modified="2020-06-17" version="1" fragment="single">VAYSSSLSGLSGDWAEMCASPDWSRRQVPGHVTSPFVTTSDSWSRDVTTPDSCSRDGTPTRAAIIGRMGGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTF1</accession>
    <name>A0A6A7BTF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_222739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006028">
        <property type="protein sequence ID" value="KAF2857778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTF1"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2857778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="73" mass="8816" checksum="2857DE6628D7C8AA" modified="2020-06-17" version="1">MSEPKDAEWQKSTKRFQNKRHSEYFDPCQEAANRSLKCLRRNEGDKSLCADYFQAYKDCKKQWVCFAKEWGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTK8</accession>
    <name>A0A6A7BTK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_220798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTK8"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2858676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="549" mass="59887" checksum="65D5182996976425" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTQ6</accession>
    <name>A0A6A7BTQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_260371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="MU006024">
        <property type="protein sequence ID" value="KAF2857888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTQ6"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="377"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2857888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="484" mass="54575" checksum="970CE30576348FA3" modified="2020-06-17" version="1">MSTADYDTYQNPLNSRYSSREMQFIFSPRNRFSTWRRLWFWLAQSQRSLGLPIEDEALRQMEANVVIADSDFPLAAQEEAKRRHDVMAHVHVFGLRCPAAAGIIHWGATSCFVTDNADLIFLRDAIDMLLPKLALAIDQLARFAEQYKALPTLGYTHGQAAQLVTVGKRATLWIQDLLDDLENWETMREKLLVKFRGSKGTTGTEASFLKIFKGDHEKVKSLDRMVTEKAGFKASTLSTSQTYSRKIDVDFIHALSSFGCTAYKIGGDMRHLAMFKEMEEPFEADQIGSSAMAYKTNPMRSERLCSLGRALSSYSSSAEQTHQAQWLERSLDDSAIRRLVLPCACLAADACCILLNNITSGLVVNKAVISQRINAELPFMATENVIMAMVEKGYSRQKVHEVIRVLSQEAGKVVKQEGKPNDLLDRIRATEFFQPILDELDELTNPDTFIGRCPEIVDEVIDTQVRPALKKYKIESGRHSQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUG3</accession>
    <name>A0A6A7BUG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_118587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUG3"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2858783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="524" mass="55888" checksum="B6E4826D8AADD595" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK2</accession>
    <name>A0A6A7BUK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_220322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2858890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27348" checksum="B110F995E9F9949A" modified="2020-06-17" version="1">MVRLTITEAAKAAVDEYQRVKRGNDFEDAHVGSPIDHDDLIKVSQFLVNRSSDHSQQKKWRLDTLLKGAMVYQSRPPPKRETTPEYQALMKHLKEEEERRQYERMTNAEKILSNGELNPHISHGTGPSADEPDDVTYADVNRQVVLIINVLVSIVACSVSIWVAARRWDVPQRLGLSMFGSVLVAAAEIAIYFGYIRRIKEAKGRERKKREQKQIVKTWVIETNEPSDGLRYRKGKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUK9</accession>
    <name>A0A6A7BUK9_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_259318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUK9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="254" mass="28513" checksum="CC3CE469C5BB0517" modified="2020-06-17" version="1">MGSEDRTVTSGLQTSGRTTFREIIGHLQAIWRQGAPAVAKELQSSVQKAMRRMVHFELYNVDIWRSINALVVSFSLCTGTRQVLWLAYPGGASSSRHFVQGTARCYPKGHPNLVRPSVSAEHCGERPRVVRGCSGLQRHGRDPAVSVTTAMAEAVAVWRWKAEQTRTTSSAGLNIHVSASSDRPYSELGEAARQRILQEDLDVYGWTEDDDVFQVTRIWLCISIYTWFHARLIDPFNIRRECGMRAGPTLRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BV50</accession>
    <name>A0A6A7BV50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_203213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005999">
        <property type="protein sequence ID" value="KAF2859013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2859013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="55" mass="6182" checksum="E1D91F565DD4D04B" modified="2020-06-17" version="1" fragment="single">SLALYAFEPENPNELRLTEGQIILVSYRHGQGWLVAEDPKTGEQGLVPEAYVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF0</accession>
    <name>A0A6A7BVF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_114285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006000">
        <property type="protein sequence ID" value="KAF2858947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025338781" evidence="12">
        <location>
            <begin position="28"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2858947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="393" mass="43840" checksum="84C76C6EA16D316C" modified="2020-06-17" version="1">MLTFRRALALALCMLVAFFVIRNATHATAHPAYLHNSPKPTGSYSDNKKLQDMPPEQPSTRASVQTSSTSTVPPASATWEGDDSGRPVAKKPQPQMPLEDLRALPLRSQLAYAFPYDVESKFPAYIWQTWKTTPASGEFEEGFRVPEASWSDLHPSFVHEVITDDVAVHLIRHLYATIPEVIEAYNALPEPVLKADFFRYLVLLARGGIYSDIDTTALKSAVEWVPANVPRTSYGLVVGIEADPDRPDWQEWYSRRIQFCQWTIQSKPGHPVLIDVVAHITEETMRRRTAGELSKVSSVIEFTGPAVWTDSIFKFLNDPDHFDMSTSSGNITWQDFTGMKEAKKVGDVIVLPITSFSPGVGQMGAGDDDDPMAFVKHSFEGSWKPESERHIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVF3</accession>
    <name>A0A6A7BVF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_221145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53649">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="867"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2858468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="870" mass="96104" checksum="8C30CE78B435A525" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVH6</accession>
    <name>A0A6A7BVH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2859143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14532" checksum="03370F1DBDA0DB35" modified="2020-06-17" version="1">MATRGSKRKAGEEEEFVELPEDDDEEEEEEYESEGGGGDDDDDDDDDDDDDGDDDDEEDKEEVEEVEEEEVEKKEKAAKSSEPQTKRRKLSPTKDDEDEEKHEEEDKNQDETDAKAETKAAEAHDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVM7</accession>
    <name>A0A6A7BVM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="205" mass="23343" checksum="EE05881B933D20CF" modified="2020-06-17" version="1">MADNWRLDNLEHVMSTLRTAAGTRALTMPSQQPSMHMPQVVAAAATGTPDPEYRCIKCWHKNKNRECSSNAPSWRQPISRAEKAKQLRRSNQCVVMLPWQYRAIPRAMRMFTSINVEAFLLDIRSSYHFIKHKTPFTSLERVNPLVRFSQAVTKSKAGEIGKATVGIGNTTFHVPKAAYSPNSPCNILSAERLWRKNKVWAHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVZ8</accession>
    <name>A0A6A7BVZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258870</name>
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    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVZ8"/>
    <dbReference type="OrthoDB" id="2580011at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="18503" checksum="2D0D0A704492C73A" modified="2020-06-17" version="1">MTSKGAASKPLHPATVHFPIAFIFLAVLLDVFSAVPLPKALETCLPSPHDSPQATYFLLSLGLLTSIPAVLSGVAQAKKTIAKQGLHEVDGTTIKLKFKALIGHALINDVVILGLTFVWWKRRSLPAGVLELWMLVTEVVLAAMQLFAAGIGGKLVYQFGFGLAMGGQKSVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BW37</accession>
    <name>A0A6A7BW37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_99460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005993">
        <property type="protein sequence ID" value="KAF2859421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="761538at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Ctf18 RFC-like complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="356" mass="40317" checksum="04DF800A8EFA842E" modified="2020-06-17" version="1">MALLVDKYRPRTLEDLTYHDGLTQRLRALADSSDFPHLLIYGPSGAGKKTRISATLRALYGPGAEKIKIDARVFQTTSNRKLEFNIVSSNYHLEITPSDVANYDRVVVQDLLKEVAQTAQVDLNAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRCLLVRVAAPTEDEIVSVLATVGEKEGLKPCEGLERKIAHECHRNLRRALLMFEAVHAQNETVTDKTPVPPPDWEALIEAIASEIIEERSPQRILQVRAKLYDLLTHCIPATTVLKTLTFKLLPKIDDSLKCDVVKWSAFYEHRIRLGSKVIFHLEAFVAKFMRIYEGHLMDMDVDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWC7</accession>
    <name>A0A6A7BWC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative U5 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_295766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWC7"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859362.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2859716.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="133" mass="14927" checksum="100D772C9B62939D" modified="2020-06-17" version="1">MYPLHINRFFQRASVAYGWGILVVAGGGSYYFAKRSINADRTKRAEGVQQQRERQELLRRQEVERTLLQKDSPSSDLAAKPGAKKKKLEDDRDPSQHGAGEPAAVEHAEHAKAGGSKWESSEPFRSQKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX86</accession>
    <name>A0A6A7BX86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_271286</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SNW family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2859713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0688">Ribosomal frameshifting</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="9">
        <location>
            <begin position="190"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="694" mass="78234" checksum="4814EDDA79C7EB02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXJ2</accession>
    <name>A0A6A7BXJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">K470DRAFT_258249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXJ2"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2860086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="156" mass="17467" checksum="029E7F328CB7E54B" modified="2020-06-17" version="1">MKAYIHDLQPGDQRSPHNSGRVVSPTHLTSLGITTLSNPTSSQLEDLAKRRGYSHRDEITISPSTLPDYEAKIEVFFTEHLHEDEEVRFILEGAGYFDVRDKEEWVRLRMEKGDLVVLPPGIYHRFTTDESDVSHLSMGKGGKGGKGIRGCISSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BY40</accession>
    <name>A0A6A7BY40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Integral membrane protein Ptm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_248218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BY40"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025551678" evidence="9">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="181"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="551" mass="61707" checksum="86EA255A210AD4FB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYA8</accession>
    <name>A0A6A7BYA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="418" mass="44013" checksum="590D920BF4FD4E62" modified="2020-06-17" version="1">MNVSRVKQETQEKMKLRNESDERAKCAVAVICDGHGSCWATLLGRIRLGQGDAAPSRSAHFYGPHTAPAAPRSPQPPPRPIFTNFLAPSQPHQSLHPTTLLPMHTRTTRSTTAAAAAAAAAADAACSVGSPGSANGTSAADAASEAVSSIASNGDKGANAGKASMAGKSGKFDHAGKPGKTGSTSKAGKAGNASTGVNTANAGDAGYVTTTAVTTAKATNKNSASTKKKLEIKQLYLEEGSEWFLLDVAHTFPGCLLPKGKLPPLFKQFAKYERGNEKIIEIHVSKNSARIRNTPDFLLHKTVEYGRGGPKIVDPNEIHTTVAETGIKCKADDKLKGPSKEKKTSGGTQANLGKEIKTDKIKPKLPPKAFFRVTPKKPIVDGIPLKIKKMRSVEFEEPKVLKKTGMAAKCSVASQMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYW2</accession>
    <name>A0A6A7BYW2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_67763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYW2"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42186" checksum="ECBA187E580F79A8" modified="2020-06-17" version="1">MVKPKLEIIPETTTVIFHGHGPDTDSSGLRGIVRLILPREMIVLNPSARLIARESTRFQFETSGRSDPMEKHEIIHRESQVVLGPLGQKYPAGVVEWPFDFKIPSQLPETVEGVTRFRVKWILGGRVFCGRENWMKSEILAKGVPIRIIRVPAWTSAYAPRYLIEEKLFPCAVSYKVDASRAVAFGSSVNVFFEITPLDRSTILERVRLELHEDMMTNLTFLGGENEVTNTKAILVKETVNIPRNPLIKKNDDSRSSNGYYKLTANIKLPESVTQCRPDVDYKSIAISHTIHIWLDFSNVDGISGATLSKGSCFPIEIFFSTLSLPDETGSTCTSSSKTSRSSERTALIPRCREVPGPYDMYGDHDIIYRPPGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY1</accession>
    <name>A0A6A7BYY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_257882</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="335"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2860440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="427" mass="45799" checksum="6ADFA209E45CB787" modified="2020-06-17" version="1">MADSGGIATLVTVARAASTSAQAAVTLSSTMSPAMTASGVGSGLSSTGRGIIIGMLSAIGAAVFLFLIVLAVFFFRYTSPGRIILDTITFHRAPGEWDDTQAFLDDEEEFLSSAPEGARTDYLRAKAWVAVNPAESFQTDISLSQFLAIQEKGVSAWEFEPELEVANCFVEARTEIEFFDCECSVQSNLPIPKQNEVYYFEAKMFDLPPETSVSVGLTTKPYPLFRLPGLHRTSIAYTSEGERRFNQPFSGTPYGPPLAQGDVVGVGYRPRSGTVFFTRNGKKLDDVASGLKTPNFFPTVGAVGPANVHVNFGQMGFVFIEANVKKWGLAPQTGSLAPPPPYGSEAGSISLEGGPEREDDASRDGSRAESPGPLNAPSDISLARWNMDRRPPLYESLIHGEDDGGPPIPTYEAATSDVAAGRDRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYY6</accession>
    <name>A0A6A7BYY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_264536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005982">
        <property type="protein sequence ID" value="KAF2860404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYY6"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25627" checksum="D72D5D951BD92BDD" modified="2020-06-17" version="1">MSPRDRECGCQDWGAWRLMRLTGGPMCDGGKKVGSEKSIKGRTRRDDERVQDVVRVVYQKRTEEKRYDHPKKSAKNSAMDPSRALYQTKARPGPHAAGPWRQAVSAVREAGDWQAHAPRRGRRPRHGARLRFTRLSDNTVAVYVELHAAHSVGVSSMLVKRLINFYTSSSQVLSIAHQNFAMRLLASVTPIKIPINLPVPTIRYNRSDPPAWLPLLSPISCRRLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ49</accession>
    <name>A0A6A7BZ49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_70445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ49"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="87" mass="9636" checksum="B12971D64AB64177" modified="2020-06-17" version="1">MLPRPAAFGCASRLTSATSCWRRFHIPLTVLQPVAWWGVMQCHKSCHISTNGVVPENKDHGRTLLDIANCIFEGQQTVRIASSSDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ54</accession>
    <name>A0A6A7BZ54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Translocase of outer mitochondrial membrane complex, subunit TOM41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ54"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="379" mass="40377" checksum="7CDF17EF3A50E579" modified="2020-06-17" version="1">MAAVPLEKEIVTVPVDGAVPVSAASSEKSALPSMPSNSSFDVVSDLYHSFHQRRAALGLRNPGSFENIAAETQRSVFLTNQMFSGLRAELNKSLSLNPLFQISHAFSTGSQILSPYTFLAIYGTNKLLCQGQIDSDTSFSGRFNFAASPRLSLKHSVQLQAAGPMSPGGAQVSIEQDYTGDDFTASLKSINPSILEGGLTGLFLGSYLQSVTPRLSLGIEGLVQKTGGGMPMESVLTYGMRYKANDWIASAQLLARGGLQATYWKRLTDKVEAGMDVNVQPPDPTSLNALMGDSKAQSSATFGAKYEFARSIFRAQIDSQGKVGCLLEKVVAPAVRVTFAGEMDHSKNAAKLGLAVSIEASGEEAMRMQETVTPASPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZD8</accession>
    <name>A0A6A7BZD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_286691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZD8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="24388" checksum="0981809DCAAF1DF5" modified="2020-06-17" version="1">MCFPFNLQLPTSRSLSDTPHHDYLNPSNKMSNTPGYSPGRDWRSRSTYTPIHASARDRYHGYNTHEEIRAAHANLIKDTNSIASTGTRPANDWRRNSNYTPINEDTRGWYQGYNTYHEAQAAGVYRQVPTTKQGCDTKMSRNAFLATMGNRHSSPTSVQSPQQPAKDSVAVDSHEARTLPYDFYKEGLWADLFDEEMAKDPLAYKWIFGKFPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZF0</accession>
    <name>A0A6A7BZF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_67018</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZF0"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2860726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="157" mass="17570" checksum="8DE8B573697F8ABB" modified="2020-06-17" version="1">MRALLCCALGHRRDMGATKVVVGVPRQNPRDVPKVERILSRLLSATLDTRELSWSATTVSTSPTSCPTSVIMGVPFEALLPYGIMVVMFGVTGGGLSGIRYIQNGGKKARRSVDQWDKNMMERDMRLTGYRRGQTDNVKAPYMFELTNPWRVEPVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZN9</accession>
    <name>A0A6A7BZN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_232397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZN9"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2860437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="915" mass="101221" checksum="3B3EEAF4FD9B5291" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZQ3</accession>
    <name>A0A6A7BZQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZQ3"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="499" mass="55402" checksum="D99787E3DA1957C7" modified="2020-06-17" version="1">MSKAPRSRSSAAQNGQHKPLAEVYSPTEPFKQKAGKKRKSVDVEDKNDGYVGSKASRRILDLGQELVAEDEAPRMVQQPKHPASLFTFESRFPDQSNRSDDDEEDKVEDGVGLEDIDDEGSWGDVEDEAEEIDPNDLEMFNNFNPAKHAPPRSLLGQDDAADAAEAQGGINLADLILEKIAAHEAQPQQSQGPGEGGQRGNDGEEAIEFPPRVIEVYTQVGLHLSRYKSGKLPKPFKIIHTLPRWDILLEMTQPDRWSPNAVYEATKIFVSSEPAIARAFMSTVLLPRVRGDIAETKKLNPHLYKALKKALYKPAAFFDGLVLPLVASGTCTLREATIVGSVISRVSIPVMKSAMALYKLCKLSEEQMRQSVESAGACNTLIRILLEKKYALPTTVIDELVAYFLRFRLLDSDNVSMAGADNQTSMKLPVLWHRSLLAFAQRYKYVISEDQREALLDLLLQLGHYKVGPEVRRELIEGRDKAALVGANKDDGDDTMMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZZ1</accession>
    <name>A0A6A7BZZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_258054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZZ1"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025690713" description="alpha,alpha-trehalase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="7">
        <location>
            <begin position="404"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="8">
        <location>
            <begin position="741"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2860299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110408" checksum="FF61CA3AE632E516" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C019</accession>
    <name>A0A6A7C019_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress response protein Rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_258088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005983">
        <property type="protein sequence ID" value="KAF2860329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C019"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025496345" description="Stress response protein Rds1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="55181" checksum="0F02CC1770FD1EA1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C024</accession>
    <name>A0A6A7C024_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_257673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005979">
        <property type="protein sequence ID" value="KAF2860662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C024"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="24603" checksum="D30F36AA979A2C5E" modified="2020-06-17" version="1">MTGVELTRKDFGTLLARTSQEISHEWLNDEIVNAFMSAIVENRKAHDKYDKESGKAPALAAFQTGWYNTWKSRGVSGIARWSRRMGIKGNKLLGAEHIFFPINSGVHWTLLLISPKSRTINHLDSMGSKSGEMLQFAREWLRMELGDAYVASEWTVAKGSSSRQDNSDDCGVFACFNALAVAEKRSFEDVTAEQMQDARKMLAALLLDPLAWREFGLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C148</accession>
    <name>A0A6A7C148_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">K470DRAFT_270168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="257" mass="27153" checksum="B859828906FA3D82" modified="2020-06-17" version="1">MPHPTTAKLMKPSPLIAAQAARYLAKTKYCIRGASLRVKKFTLKGCYAFDEDDGPTESPRIVSCPETEPKVAHVSKRIGGDKSGDMGGHYSAGLISDLKEMKHAGSSESENMDGVSNDRDEAAGLEVMSASEDSDYTSVEPNDGDKTATKPASSSGSTGTCAVSSEGNDWSESMVVVIEEKYVELSTSHDTGVFYSDGGNVAQVTEKCACSTSSDDMGVFTSEGKDGSDSTCVAMIQVEEEKVACSSGREMSSEGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C162</accession>
    <name>A0A6A7C162_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_270089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MU005974">
        <property type="protein sequence ID" value="KAF2861241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C162"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="201"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2861241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="696" mass="79769" checksum="C2236985272CA5A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C191</accession>
    <name>A0A6A7C191_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_276209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005973">
        <property type="protein sequence ID" value="KAF2861271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C191"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="698" mass="77408" checksum="FE4DCED5D448B096" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1B4</accession>
    <name>A0A6A7C1B4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_232457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="MU005981">
        <property type="protein sequence ID" value="KAF2860478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1B4"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8 9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2860478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="291" mass="32976" checksum="D2DF097412155D57" modified="2020-06-17" version="1">MSGGWNTIESDAGVFTSLIESLGAKNVQAEELLTLEPESLQELDPYGVIFLFKYPKTENKAPRDGESDSEANIWFARQTIQNACGTQALLSILLNQDIDLGKTLQEFREFTLSFPPEYRGEALSNSESIREVHNSFAKASPFMSDESRPAEEDDDVYHFIAYTSIDDTLYELDGLQPSPIRHGDHGACPKEILADAVVPVLQRRIERYPPTEIRFNLLALCPDMLQKAREEGDAEAATREKAKRDRWHWENSLRRHNFVGFIGEMLKGVTEMKVKDGSYDDWLAKAKADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1G8</accession>
    <name>A0A6A7C1G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_257292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1G8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="103"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="317"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2861142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="797" mass="89861" checksum="DE9ECE784BB98AD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1J9</accession>
    <name>A0A6A7C1J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_46639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1J9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="72" mass="7885" checksum="EF5496B5C0257AEA" modified="2020-06-17" version="1">MLPLEKVFPGTRHGAVHALCVLGDVVSVNAARPRLARGKVPHFASPHHLNTYIHAHSNTYTCLTLHCLPQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1S2</accession>
    <name>A0A6A7C1S2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_281609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2861353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1S2"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2861353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="174" mass="19725" checksum="12CF13BCED58E36F" modified="2020-06-17" version="1">MGNANSATIEGIVQNSNFDRDEVDRLRKRFMKLDKDNSGTIERDEFLSLPQVSSNPLATRMIAIFDEDGGGDVDFQEFVTGLSAFSSKGNKEEKLRFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTMMEADLDHDGKISFEEFTKMVENTDVSMSMTLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1X7</accession>
    <name>A0A6A7C1X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_276160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="581" mass="63865" checksum="5FAE7DC36E2B5CD4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C227</accession>
    <name>A0A6A7C227_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_34143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5417811at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025643943" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2861636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="161" mass="18493" checksum="B7F759C3DCAFFCCB" modified="2020-06-17" version="1">MIFFSIFFAFLFFVLRCWIFHRCNLSSDPEVGIEELRPSQQLREEEVEGAFLPARPIRVHVQEDDNSADRVGIGEIWDELDSPGSQRRPIGQGQLTQQELLTEPRGRSLTQPPPAYGRWRNSVRVDPKYLHWKAVEVTETGTDAGNLPSPRYEDAVRNGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C278</accession>
    <name>A0A6A7C278_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_256752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005971">
        <property type="protein sequence ID" value="KAF2861621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C278"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34429" checksum="6C7160ACDE9F2DB0" modified="2020-06-17" version="1">MDKFASTFQSLGQTVSSSVSPFAARSQQWFREQTGNVSEKTELPHEYVELETRIDALKTTHQKLLAATSQYANEAYDYPPNIRESFQDLGKSISEKVSLLSKAQNAADAQAALTASPSGKPQPKTFNHAMARAALTGSQVQTMATPQGSVEPDPLAQGLEQFAIAEEKVGEARLVQDEKIQGKFLAGWSTTLNQSIKAADKARAAVANARLTLDAAKNRAAAGGRHEANYSDAQRKQIEQAEDVFVEKVDEATNIMRNVLDTPEPLRNLTELVQAQFEFHQRAAEILEETCRNIGEIQMDQETKYRRSRDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C279</accession>
    <name>A0A6A7C279_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_32327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C372"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2861702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="163" mass="17558" checksum="0D70616048CCA7FB" modified="2020-06-17" version="1">MSLTLHTSHGQIKVDLFCSLCPKTCYNFLALAATGAYESSPFHRIIPGFIVQTGSPASAGIKSSPSIYGFPFEDEIRSSLRHNAKGILSMANKGPGTNGSQFFITLAPAPHLDGKNSVFGRVIDGWETLDELEKTEVDAKGRPANQKVTVDKVEIHANPLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3K9</accession>
    <name>A0A6A7C3K9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_293788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3K9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="789" mass="86260" checksum="F691BF3E221062C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Q6</accession>
    <name>A0A6A7C3Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_269419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="MU005969">
        <property type="protein sequence ID" value="KAF2861887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Q6"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2861887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="328" mass="34439" checksum="97845D5F73B9A4D7" modified="2020-06-17" version="1">MKAVVAGASGGIGQPLSLLLKTCPLVDKLALYDVVNTPGVSTDLSHISSTATIEGYLPENGEGLKKALSGADIVVIPAGIPRKPGMTRDDLFKINAGIVKGLIEGIAENCPDAFILIISNPVNSTVPIAAEVLKKAGKFNPKKLFGVTTLDVVRAETFVQSITGERDPTKTVIPVIGGHSGETIVPLFSQAKPSVKIPADKLDALTNRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAQRVMQAAKGESGVIEPTFVYLPGVNGGEEIAKETGCEFFSVPVELGKDGAQKAINVVKNANEYEKKLLSKCYEGLKGNITKGVEFVKNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3Z1</accession>
    <name>A0A6A7C3Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_27457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005970">
        <property type="protein sequence ID" value="KAF2861685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C3Z1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="65" mass="7611" checksum="072D1E8C1C2842DE" modified="2020-06-17" version="1">MVHSYRLAFSKAHVLGIRTVQVLYVHAPFRDRYTAIHFKWHPCRDNASTAPANIFYILCAHKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C499</accession>
    <name>A0A6A7C499_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">K470DRAFT_38154</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C499"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="542"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="814"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="437"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="933"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="963"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114926" checksum="73AC549B86895F98" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4F7</accession>
    <name>A0A6A7C4F7_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Ras small GTPase</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">K470DRAFT_18258</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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            <end position="33"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <position position="51"/>
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        <ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="182" mass="20495" checksum="AB37027652A086EC" modified="2020-06-17" version="1">MGIFQRFYDWLLNLFWATELDVTIIGLQNAGKTSLVRVLAGGEFTIDSTPTVGFNMKRVHKGHVTLKCWDLGGQPRFRPMWDRYCRGASAIVFVVDSTDQPALPVAKEELHMLVNKPAVERIPLLVLGNKSDLPNHLTVDELIEELDLKAVTNRELSCYGISAKEETNLDAVMQWLIARGQK</sequence>
</entry>
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    <name>A0A6A7C4K2_9PEZI</name>
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        <submittedName>
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    </gene>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
    <sequence length="900" mass="100749" checksum="EFF4E850D6474FA4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4X8</accession>
    <name>A0A6A7C4X8_9PEZI</name>
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        <submittedName>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005968">
        <property type="protein sequence ID" value="KAF2862099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4X8"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2862099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="454" mass="49968" checksum="2A0B832989E1E76A" modified="2020-06-17" version="1">MNTRKPIQPPNTSVVHALSFSSTRSRFTAALSNGIHCFRSDNCLTTYWPRLPAEGGIGIAEAIDDRYIALVGGGREPAWKPSEVIFWDAVLGKETKRFDMHEPIRGIRISARWLVVLLLKRVLIFRYQKLAGEGLMAPNIIRPIITTGSNYYGLASLSGSILVLPQQACGQAQLISLEKNNLRILKAHQASVRSLALSDDGSLLATASERGTMIRVFHTQTLQLAFEFRRGVDQARIYSLAISPKNRWLACTSDKGTLHIFRLSHEPLTISGRPNSHSNRPASQPTRPPSSQQSSGGRSYASNTQGSVQEYYNLRPATGTSLSPPRLSMGATALGILKKTPFTPRAIRDIRSVFSTEFHIGDDDVYWQGGPSTPIVTEGPEGKKIKAPRPVLPLPNDPLGRPPKGVLGFAKEEGETAVVRVLAGGMDARWEEFEISSEGIVHRGFRRLLTRQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4X9</accession>
    <name>A0A6A7C4X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4X9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="74" mass="8631" checksum="533CB3C0C2AB9616" modified="2020-06-17" version="1">MNLPDPVERPRTMKTGDPMNIDRMNAVLTQASGQRLCTQAFRDRKEGTPYFTCGDLGYGWPQCPHRDFKVWKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Z2</accession>
    <name>A0A6A7C4Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_255583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C4Z2"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="256" mass="28427" checksum="69DFCEEFBEE669F4" modified="2020-06-17" version="1">MRPRTTWLRLTPCFRRDASVLHSPNTHRSPLARKTQLHRQYQSLLRSTPLMLFFQHNSLTAREWESVRRELRRAVGDDGAGAAVRLQVVGTGIFDSALRVVEFWDRDTGGLSEEAWRATSKGNQPDLHHPFEDITCGPLAVLTFPSIDPTLVKAALQILAPQASAFPAPKKRLTPSYYERPVQDGVAKLMLLGARVGRNAQDIDGVRWLGSLPNLDGLRAQLVAILSSAGRSVTDTLSSPGQGLYITVDGRRRMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5H7</accession>
    <name>A0A6A7C5H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_262629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5H7"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="100" mass="11064" checksum="7E66E95006279E67" modified="2020-06-17" version="1">MSTAPISLQAFGEAITSLTSGNLFAKAAEIDNSLLHLVQSNEILAQEDDDECRLAVKENEELIKTLKKRLNLLQSEVEKRGLKWTEKESVNGEGDEGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5I7</accession>
    <name>A0A6A7C5I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">A/B/D/E cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_255622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5I7"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="240"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="333"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2862700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="465" mass="51945" checksum="E94B1F1AEF3FC748" modified="2020-06-17" version="1">MPPARATRRAQTDENADAIPQRVTRAKAAALETGAEPKKALAAKRTTTTAASNGAQAGRKRTALVDVSNQNKKDTDKAEGKKDASGKLTLAKTAKPTGISKTTRTTTSRTVKPAPAESKRAASGSGVGGHVSKKRNTTQVVAEEVVQDEVVTEKSTVTTSVATKVEETEDLETGKPTIEDIVKLAKDLDAEDSRDPVHVSEYVHEIFEYMRELEVSTQPNPDYMDHQADLEWKMRGILVDWLLEVHTRFRLLPETLFLAVNIIDRFLSCKVVQLDRLQLVGVTAMFIASKYEEVLSPHVMNFVHVADDGFSETEILSAERFILASLDYDLSYPNPMNFLRRISKADRYDVQTRTLGKYLVEIACLDHRFIKYVPSHVSAAAMYLARLALDRGEWDANLTKYSGYTEEQIQPVFKLMVDYLQGPVVHDAFFRKYASKKFLKASIVLRAWARKWGPHFLGQEPKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C623</accession>
    <name>A0A6A7C623_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_268517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C623"/>
    <dbReference type="OrthoDB" id="5598835at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47716" checksum="D2F6C46999CFDFDC" modified="2020-06-17" version="1">MLKTSGKARNMCAWLRLIVMRCEPLCAVEDLLLRQAVRYDPIPRTSLTRYLMAVHAEVVQQVNSRLPNYFGIVFDGWTERRTHYLAIFAVYDAKSAASKLSMLAFTTFQDQTNLTADNNIHLLEKVLDDYTKSRSAIIFAIGDNCQTNQAIANRMCHPFIGCATHRQNLAVQDILDEYEADLRRINEIMVCRGKIKKMDELRKRTKLQPITRNATRWGSTYHTPKRFFKLELSIDKEGDELAAKLPNSETRLKLKGLMENTLSSLEQATKLLQGEDVSLAVARCIFDWVVKKLPQTELRLNNRTAVIVNPDFEDGTVKVLDGQAESLTSHQKQAVSIFRVGEPEADALDDDDLAPHLQLKRARKSRSSTYLNLSYIHATSKTCERVFCLARRIKIDYRKSMSDQTFEALMVLHANVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C695</accession>
    <name>A0A6A7C695_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_227455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2863021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C695"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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</entry>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Barry K."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C782"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2863290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="323" mass="34937" checksum="9794A467A11A4488" modified="2020-06-17" version="1">MTSLLGTATKATSRLSPLVGRAYDPPRGNPPVSGRSPPPPPREDLANVKDNIHPPTFLGTSKRLPEFSLHDRVVLVTGAARGLGLVQAEALLEAGATVYALDRLPEPSPDFYRVQERAAKDLGTTLHYRQIDVRNVPELNQIVKKISDDEGRMDGLVAAAGIQQETPALDYSAQDANTMFEVNITGVFMAAQAVAKEMIRWGNGGSIAMIASMSGTIANRGLICPAYNASKAGVIQLGRNLASEWGQYGIRVNTISPGYIVTAMVEALFEKYPERRRDWPTQNMLGKLSKPEEYRGAAVFLLSDASTFMTGSDLRIDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7C9</accession>
    <name>A0A6A7C7C9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_122508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7C9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2863303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="95" mass="11186" checksum="F4384B9246D66CA8" modified="2020-06-17" version="1">MPPQGHPRRSIKTISSHDTWQALWYPWIDTYQGPNNVIRCWDQISPRSNFDGKQSYWGSLAKKFLLRRIGAWEKSSGTTHLRMRSCIGQQLHAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M1</accession>
    <name>A0A6A7C7M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_274840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="219" mass="25242" checksum="264DFA10A68E86A5" modified="2020-06-17" version="1">MNIIEWAFGKRMTPAERLRKHQRALEKTQRELDRERIKLENQEKKLVQEIKKNAKNGQMGAVKVQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATMLLGSMNRQMNLPALQRIAMEFEKENDIMDQRQEMMDDAIDDVTGLEDEEEGEEVVNKVLDEIGVDLSQLLGETPQGIQQAAVPNGKVAQAIGGDPDDDLQARMDNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7M9</accession>
    <name>A0A6A7C7M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_254788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7M9"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="411" mass="44931" checksum="B7F5E7E5CFE89780" modified="2020-06-17" version="1">MVWAALHRTIRAVDVQTCEAGEEDAFFVADLGHVYRQHRRWQQHLARVTPHYAVKCNPDPQVLQLLAALGAGFDCASKAEIEQVLAMGVDASRIIYAQPCKTRSYLGYTAAHNVRQMTFDNADELYKIKAVAPDAQLYLRILTDDSASLCRLSQKFGAAVDQVPALLQLAKNLSLDLVGVAFHVGSGASDPAAFTQAVIDARSAFDQAAHLGLHLTTLDVGGGFVSETFDTMADNLSAALDKYFPPSIRIIAEPGRFYTSAAFTLACNVIARRSVSSESAMLYLNDGVYGNFSCIMFDHQQPIPRILSTRRMPHGLRCPRSSPDSGYVSAEDESSDTGTAIHYSIWGPTCDGIDCISIRWLSSATVEVGDWLYFTDMGAYTKCSATKFNGFTNKHRTVYVCSEPAARELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7X3</accession>
    <name>A0A6A7C7X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Squalene synthase</fullName>
            <shortName evidence="19">SQS</shortName>
            <shortName evidence="19">SS</shortName>
            <ecNumber evidence="4 19">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_210704</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Squalene synthase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS). Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. The presence of a gene encoding a squalene synthase supports the identification of the cluster as being responsible for SQS1 production and suggests a likely mechanism for self-resistance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="19">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 19"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7X3"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2863337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="487" mass="56215" checksum="B67939A4CB92C175" modified="2020-06-17" version="1">MVSAQSVLYYLTHPYELRAILQWKTWHSPVHERDESQECETLRECFRFLTLTSRSFAAVIQELHPELLVPVCLFYLVLRGLDTIEDDMTLDLEKKEPLLRNFHNVIDDPKWTFNGNGPNEKDRELLVHFDVVTKEFAKIKEPYKVIIRDITKRMGNGMADYARKQDNTANVVITIKDYELYCHYVAGLVGEGCTRLFVEAKLANPALLQRPELIESMGQFLQQTNIIRDIREDHEDHRYFWPKEVWSKYVDQFSDLFLPGKREKALHCQSEMILLALGRVDDCLFYMAGVKEQSVFNFVAIPQAMAIASLELCFQNYTMFERNIKITKGQACQIMWKSTQNLQVVCEVFKEYVRKIHAKNVPTDPHFLDISIACGKIEKFIESIFPSQVARPLPLAPAETLSPEQEARKKKEEADAKEELFYILLAVAITLVIVFTCMIGLAWMFGARFDLAFEGIKTSLKEAWQMLSQESAAPTPSDLKHAVHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C856</accession>
    <name>A0A6A7C856_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HSP90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_262175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C856"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="78"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2863432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="703" mass="80182" checksum="AE4F3FB5749EFF0C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8A2</accession>
    <name>A0A6A7C8A2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Capnodiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 480.64</strain>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18269" checksum="A9C6A4B20150CF2A" modified="2020-06-17" version="1">MNNCSIYDRNAPRTIPSNTYQIIRTLHTRPDRSAHLAIHLLAGSLRILKTLTSEPTEIILLLCYLKNHPFFPHTFETRNETPNTWLITLDYCSGGDILDYLPTWSKTCPSPLPVSFSKKLISYLGDALGFLHLEVTSTEQPIARRRGRRGQEGIYPPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C970</accession>
    <name>A0A6A7C970_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_267488</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025544848" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="329" mass="34446" checksum="31CC2677CFC04775" modified="2020-06-17" version="1">MFSNVNFLTLVSGLLSLAGPAFGHSWIDEFQVIGSSDSYTGKRGFPRGYPMLQAQSGSCVAMKHLENGHATLPWNQLGKPKTGGTVFIYGTTQMSESKKMVDVHQWTKDGKGGNGLGFLMAAQIYDDGPLSQPCPGPAHIQPREMVREQCPDPSILAGGGKDEYYTTCADFNVVNSVPLPAASHTLAQGNPQTAAVSNFRTAYTTSPAVIMMSGTKTIGATLATATQYGACTNPTPAPVPASYSPVAVFDGAAYTSALKMNKQLAGLTQSLGAATAQPTSVATVCYGSASATDGASMIQALGPQPPGTYLSWALQERCFRHWGPSTGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9R3</accession>
    <name>A0A6A7C9R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_267174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
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                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
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        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2864306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="398" mass="43086" checksum="201FE9014E32E52A" modified="2020-06-17" version="1">MALVASAITIHAAPMSGILADCSSKGISLRQVEYGQRLRNGPAEVLRTYNKYAWFGSSGKRPYLVQRVAETWANASVEARPEDYETSYTCTITIGQDSFDMNIDTGSADLWVFSAQLPGNLIGNHTAYNPSKSGQPLQNHSWGISYADGSGAAGIVYSDKVVVGGATVTNQAVQAATSISQSFVVHEKYDGIVGLGFNNMNTVKPQQQKTFFDNVKDSIPQRLFTATLKHNSPGSYDFGFLNRSKFRGEIVYVPVDASRGLWTFDAGSFSVGNGRLQGRIGKAVADTGTTLLFVPQGIANAYYNQAPGARYDRSQGGYIVPCDSRQLPAFNIQIGSQTISVPGYLLTYSPVGQGMCFGGIQPSQQRDFNIFGDIFLKAVYAVFDMTQDQPRLGFAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA67</accession>
    <name>A0A6A7CA67_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Ras GEF</fullName>
        </submittedName>
    </protein>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1055" mass="116729" checksum="5D9ABC587FC275E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA78</accession>
    <name>A0A6A7CA78_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864431.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="359" mass="39040" checksum="32E4293DAC0854C6" modified="2020-06-17" version="1" fragment="single">MPVATQASLKGLTPTQLEETGCRLCLNNTYHLGLKPGQPVLDALGGAHNLQGWKHNLLTDSGGFQMVSLLDLSTVTEEGVRFSSPHDGTPMLLTPEHSISLQHSIGSDIIMQLDDVIATTSPDHTRLEEAMRRSVRWLDRCIAAHTTPQTQNLFCIIQGGLDPALREECCREMIARNTPGIAIGGLSGGEEKSAYCNVVATCTAVLPRDKPRYVMGVGYPEDLLVSIALGADMFDCVWPTRTARFGNAVTDEGVFNLKGVRFSCDFDVIDSKCGCEACKEGKGVSRAFIHHVAAKETVGAHLLSVHNVHYLLGLMGRVREAIASGTFPEFLRRWFDVRFKGEPPGWAVDALRAVGVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CAS6_9PEZI</name>
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    </protein>
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    </gene>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2864550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="83" mass="9311" checksum="897105E00B0374F5" modified="2020-06-17" version="1">MPSQRSTLAQPARSKKYSFSHTHPERRLPSTATGYPLTSSHGSMLSKPTRLTRAYGAMLTSLVTNPTSLFYLSGQFVQSRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CB79_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29333" checksum="F6E185471AF7A034" modified="2020-06-17" version="1">MRSDDEAALKRRIAPELTAGNHRIWFRTIEEAMEAKGIEQVIGIDSLETLIEKLQIEKANDKAAADVKQKVKQMDAKARQLMRRHLSEYDLELLDDYKTARGWWQFLRKKYGRKTTAQNHQAMVAYVNFKMTPQMSVDEGWATLRSLAKDAEGVDGFKHSVASRARRLIEALPSEYDATKSVLRASDYGADVILEKIKEKEATLKTSNEEALAARVSRGKAKQKSEPRRRGRAKPTKQPNNAKVSCFLRGEPSSFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7CBN6_9PEZI</name>
    <protein>
        <recommendedName>
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        </recommendedName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2094445at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
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    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2864542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7817" checksum="40C24083B0089CCA" modified="2020-06-17" version="1">MVAYYEIFGQKVGSHVLSMAVLGLLGGGITMVTGGSKAKSVAQGPPINASSKDEEKFIQDFLKEAEGEKKGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CCI1</accession>
    <name>A0A6A7CCI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CCI1"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2864555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="135" mass="15632" checksum="9F43B4C73DA980F2" modified="2020-06-17" version="1">MWVHDEVTASCAGRDETMEARVRNFIASRWKNIGTMAMYLAAILDPSLQKDWRPTLNPEGLRAVMAWLDVRYLTDRPQMYGKLMRFVNNQILYNDEFLRAAAACMSPLFWWKMHFASKISELVQDMLSTTSTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CDC6</accession>
    <name>A0A6A7CDC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_254039</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CDC6"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="16">
        <location>
            <begin position="479"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="280"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="582"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2864388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="626" mass="71108" checksum="E4C08E29B1B7D34C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BP71</accession>
    <name>A0A6A7BP71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_267021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006060">
        <property type="protein sequence ID" value="KAF2857176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BP71"/>
    <dbReference type="OrthoDB" id="10395117at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="151" mass="16241" checksum="B0E561FE71205550" modified="2020-06-17" version="1">MADRVSVSISIGGRLSADLLGELIEKANAENLSTEWDGEPFTANDLPDGEPLVLRGHDIANGKIDEIEDFCCTNDLPFWRWSGGAPGSFPAEIVIWKGVGERRAFTADEDGRPVLTSDEAGEIATLDDLREHFATGAYLPPPFVLVPTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQH5</accession>
    <name>A0A6A7BQH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_260773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006041">
        <property type="protein sequence ID" value="KAF2857474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQH5"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2857474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="349" mass="36897" checksum="1B8604F7841DA825" modified="2020-06-17" version="1">MADIFTCPPLTRESVKTAHEIIKPYVHLTPVVTCSTLDALSNGNKLLFKCENTQKIGAFKARGAFHALSHLLSNVGHEALCASGGVITHSSGNHAQALALAAKTFNVPAHIVMPSISAPSKIAGTEQLGARIAFSGSNSEEREALVEEIRAKTGATLVPPYDHPDIILGQGTLALEFEEQVKALSVSGGLDAVIAPIGGGGMMGGVCTALEGTGIRCFGAEPAFQGANDCEKGLREGKRVESVNSLTIADGARTPVGEIPWKILTDKKKFAGVYSVSEDEIKMAMRLLMERAKVFVEPTAALGLAVVLFNQEFRELIKDKGWNIGVVLSGGNTTVEALAKLFKDDSDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQK8</accession>
    <name>A0A6A7BQK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_170325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006038">
        <property type="protein sequence ID" value="KAF2857550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQK8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2857550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="246" mass="27690" checksum="FD5F3402C6878F28" modified="2020-06-17" version="1">MPAGTWWHGPVGGMTERLESLSKPLRRNLDLTNHHAPGLDLINKFSVFLLEQHIALEGWWCVDNEYMTRAGDELLNLCQEIWMRSMIGLPYPKISGPKTQRLRHQLPATTQAPHNRLVSTYDLRWSRTVYRQFSRCLEAISCGAGSFVQCWESSTIFRVNAPLQQVKTPQTAIALVEEFRAVAPQNANEDIGASVKVPLLASTRGYKIVPIEDLGSHSQCDAFVWRGVWREAGSHRLSKGKADGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BQX4</accession>
    <name>A0A6A7BQX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative siderophore-dependent iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_238688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006053">
        <property type="protein sequence ID" value="KAF2857287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BQX4"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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                <person name="Bloem J."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006013">
        <property type="protein sequence ID" value="KAF2858286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSJ4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="160" mass="18455" checksum="39CFDFECCF4675DB" modified="2020-06-17" version="1">MTVSLENKERFNRLCTAPQPDQSDTRQVRQMRSFLYVGDKRTISATAQALWRPKWYRILFSSGVHYTSFAFLNTKFCHERLIQYVSALHHFSTDTSVREAMPFRHSTAGHLADEVLDLLEDFAAEAMTVDVEAATAHVERELRELLECLLVDALRSCLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BSY8</accession>
    <name>A0A6A7BSY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">K470DRAFT_152064</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="MU006025">
        <property type="protein sequence ID" value="KAF2857849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BSY8"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2857849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="249" mass="26882" checksum="7A600959A4D6DDA0" modified="2020-06-17" version="1">MPRPIIAPSILSADFAVLGKECADTISRGADWLHVDIMDGHFVPNMTFGAPVVAKIRPHVTRPTEPFGKGTFDCHMMIAEPKKWVKDFQKAGCDLYCFHYEAAINSTAAESPEEKTDQKTSPREIVRYIHSLGMKAGVAIKPQTDVSVLYDLFDNETKSEVPDMALIMTVEPGFGGQKFMANMMPKVSSLRTRYPNLNIEVDGGLSESTVDTAANAGANVIVAGSAVFGADDPAAVITKLGKAVDSCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT68</accession>
    <name>A0A6A7BT68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_283275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006010">
        <property type="protein sequence ID" value="KAF2858410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT68"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="125" mass="14217" checksum="4FE927D7E169872F" modified="2020-06-17" version="1">MAPINVCASKRGQKVTKKFILNATQPTQDRIFDPSAFATFLQQRIKVDGRTGNLGDTITVTSLGDGRIEVVAHQEFSGRYLKYLTKKFLKKQQLRDWLRVVSTNKGEYTLKFFNVVGDDAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BT76</accession>
    <name>A0A6A7BT76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">K470DRAFT_222372</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MU006023">
        <property type="protein sequence ID" value="KAF2857915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BT76"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="988"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF2857915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115846" checksum="8F4152D4D17FAAE9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTG4</accession>
    <name>A0A6A7BTG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_289576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006011">
        <property type="protein sequence ID" value="KAF2858372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTG4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2858372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="71" mass="7785" checksum="C713C9950CDB80D2" modified="2020-06-17" version="1">MTSDTNDTLNSNVVGTVDLDIIVKLQTVGESAINVEYFPSRFTEARIRLPELRSCTSVFPNGMLVVTGTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BTN2</accession>
    <name>A0A6A7BTN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_221498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006012">
        <property type="protein sequence ID" value="KAF2858307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BTN2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2858307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="533" mass="57874" checksum="02568EE5793BB617" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU68</accession>
    <name>A0A6A7BU68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_118919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006003">
        <property type="protein sequence ID" value="KAF2858791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU68"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32748" checksum="2FA592D7E8BF014A" modified="2020-06-17" version="1">MASDPAKTVAASDDPVQTSANPQGERLPPPPYATNPAAGIPQRGNSLSERYPGDKSVQPLDVIRKDSRKAQRAPHLTKAQLPGPDTIDRLDPAIGGIPYHHEGPFDAATLGRNVDPKTSPLAALETSNQEALKATPAEKIRDAVEGHRPLEGVAAVPPGVPDQFGRTYDYEEGTDLMREGGPNDAGYKRWPGKAYDDEDLKGKSEPAFGLDRALKSHTVGEDSIDIEDRAHLNKDYHQAEQSGKLDQRDPVKIAGDDGKYADMELANAASHETSHEAPDASGRSGGLREGIKKRIGSLRRKHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BU76</accession>
    <name>A0A6A7BU76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="14" type="ORF">K470DRAFT_259511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MU006004">
        <property type="protein sequence ID" value="KAF2858693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BU76"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="566"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="917"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="634"/>
            <end position="636"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="641"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2858693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112843" checksum="673E47292149C31F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUH4</accession>
    <name>A0A6A7BUH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_265820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUN0</accession>
    <name>A0A6A7BUN0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_288844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2858904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF56">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2858904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="593" mass="68059" checksum="DD36935A050F5873" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUU4</accession>
    <name>A0A6A7BUU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_131657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU006009">
        <property type="protein sequence ID" value="KAF2858485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUU4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2858485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="166" mass="18693" checksum="72F27EF74B6F8768" modified="2020-06-17" version="1">MLVGLGLPSYWVDKGFANAKPLMTDLSHWYPTQDEPTLNRFNTHQTPFRILYHYAANPEHVCSHITLNPNCQRQNSYPTGLPAVCTLQLRIPFLLTHSYIPVISESRAVGCFMVVHNPICSCYVPISMYTLRKIQNKHNGVNPLKNNNLSKQSASIGGSLVSLHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BUU5</accession>
    <name>A0A6A7BUU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_249885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BUU5"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="792" mass="89578" checksum="E4A5D98D33ED7971" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVB6</accession>
    <name>A0A6A7BVB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_300723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU006005">
        <property type="protein sequence ID" value="KAF2858669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVB6"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2858669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="540" mass="60547" checksum="A65258FC09F0353C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVB9</accession>
    <name>A0A6A7BVB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_109995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU005997">
        <property type="protein sequence ID" value="KAF2859154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVB9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2859154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="605" mass="65717" checksum="9A6D5BFDF833B87D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVE8</accession>
    <name>A0A6A7BVE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">K470DRAFT_259068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="MU005996">
        <property type="protein sequence ID" value="KAF2859180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVE8"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2859180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="214" mass="24538" checksum="01D5205ED35242AB" modified="2020-06-17" version="1">MATTRMAARRAFNPPIVRQYSTCKSLTPSQKEYLSSALRVNHAGELAATLIYAAQTPVILRSYPHLRGLMQHMYDQEAGHKAYFDDMLVRHRVRPTAMYPVWYVASTALGWATGMMGREAAMACTEAVETEIGEHYNNQVRELMKWMREMEERGEDVGEELKALTANLRRIRDEELEHLDHAVEHDAKQANPYDLLTTLIRWSCRGAIKISEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVE9</accession>
    <name>A0A6A7BVE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_271631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005994">
        <property type="protein sequence ID" value="KAF2859316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVE9"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="186" mass="21345" checksum="D6D97C16562CB190" modified="2020-06-17" version="1">MSLPEPFLFSSSQHSSLISQIVSIHSECIIHDLQAVTFLPDKNGNIDAGKMENYWHGLGREVAQGTRLVIVQCTDEKNDEVMGIVSLNMPVMECGPFRGYVEKLLVAVKHRQKGVGRRLMERLEVEAKERGKWLLILDTVVGPAAEKVYRRLEYIEWGLLPNFSINPRDGTLMDERWFYKDLRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT1</accession>
    <name>A0A6A7BVT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor 3a subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_221005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU006007">
        <property type="protein sequence ID" value="KAF2858598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVT1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2858598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="489" mass="56914" checksum="D1C2BC54AC192FDD" modified="2020-06-17" version="1">MLYEDLRYIHEDVERLEQAITDWVREDPKRVRRRLVRDHAIARLLDRVQAQSAKGLQYYNEQQHALAQEVQSLSVGDSFAEFYRQVAPIKDFNRRYPNEPVENLETAYNFYREPEFAQQVEAMFTGEESFGRYLDLTILHEEYLNLPGVKGIRKLTYLQYLDAFDVFVRPQCPVTRETKMTEPYFAYVNGLATYLEGFYRKTRPLEDTDKVIRMFDQEFDELWEKDAVPGWEKKVATETEGSGQGIWCAPCGKEFSNENVYTSHLKGKKHIRNAQQSGENAAAALLGSGKRLKERVVAEREHRVRKLSAAMPTQREDTRVNVERKAGMTDRERQQELEALYNEDDESGEEPEAEEEDGEEKIYNPLKLPLSWDGKPIPFWLYKLHGLGNEFPCEICGNYVYMGRRAFEKHFSEPRHIYGLKCLGITQTSVFREITGIEEAARLWEKVKKDKIAEAARKQGGDAVEEMEDAQGNVMPKKVYMDLKKAHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVT8</accession>
    <name>A0A6A7BVT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">K470DRAFT_219066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVT8"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2859466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="108" mass="11470" checksum="13D597955A461DF4" modified="2020-06-17" version="1">MAPKKSTKASDSINAKLALTIKSGKVTLGYKSTLKTLRSGKAKLIIIAGNTPPLRKSELEYYSMLAKVPVHHFSGNNIELGTACGKLFRCSTMAILDAGDSDILSSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BVX1</accession>
    <name>A0A6A7BVX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidative stress survival, Svf1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_282771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005995">
        <property type="protein sequence ID" value="KAF2859293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BVX1"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="215"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2859293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="380" mass="41743" checksum="652368499AE1B67F" modified="2020-06-17" version="1">MLSWAKSAVGLTEPIYGESAVQPVSTQAQSQPYTILTRDDLAWTCMDGTNVETKTFYIFSDAPNKIGLVQIIYSNVMGIRTTAQFNLKIFNQEGDGKHLWVSDNLSDFSFSQDKQTFTSKQGVELALSPDGEMYSFRAKSSNGVKVDLSFKRAAEGFMVGKDGTTYFGTDPKKPWGRMTHLFWPVCAVEGSVTTANAEVVDIKGRGVFIHALQGMKPHFAAAKWNFGIVNSQRYTAVMMEFTTPLSYGSTTVTVGGIADAKEGRLITASASPSVSVKHVQTHQDARSDWPEPTDILFQWKGETADGKGVTAKAEGPLGTRVDRVDVMGELPKFVKQIAASASGARPYIYQYTPKIELEVDVWGEKVEEEGQLFMEATFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWI9</accession>
    <name>A0A6A7BWI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_258758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005991">
        <property type="protein sequence ID" value="KAF2859581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWI9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="96" mass="10368" checksum="E6BF199744922C77" modified="2020-06-17" version="1" fragment="single">MSSIFCNCKKSENASVLSPAVGQFFQGERCAQQMAANSRAKRTSSSTTRQSWRGFSRFSATRDSSSAPSSIGHQAPRVKVYSTTPAGRLEGLTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWT4</accession>
    <name>A0A6A7BWT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_97081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005992">
        <property type="protein sequence ID" value="KAF2859457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWT4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2859457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="62" mass="6952" checksum="F8B5232D314EA1F8" modified="2020-06-17" version="1">MEDVSPGAWLRQRTLSRRMPFGPGRELEQSCSASLLWTSDGFHSEVSHTLLTASPFTNLEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BWV9</accession>
    <name>A0A6A7BWV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">K470DRAFT_218572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MU005989">
        <property type="protein sequence ID" value="KAF2859720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BWV9"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
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        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
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    </dbReference>
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        <property type="entry name" value="TOPO_IIB"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
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            <begin position="170"/>
            <end position="247"/>
        </location>
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    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="81"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2859720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="365" mass="40461" checksum="9BC39743A61199F6" modified="2020-06-17" version="1">MSIQFQIETHLHKLTNQLLSPDRKEITITLPRPARSTPTKISFPGRNADEAWRFTVVLRLMEMIHEALRNDTVLSKRDLYYRDPALFRTQATVDRWVDILAASFGVSREQLNVTAAAKGLVAGNIIFTLQTNYRTPSGVGHQTLRPPTSGFLIPPTRSITHLTLPRNITVLVLEKEATFRSLLSTQFWRSHSSHLVAITGKGYADLSTRSVLHKLCTPSRVNGHAAPKVVGLVDWDPDGVNILLVYRGLGGGDGEACVARTAATAAAPAARPVPERLDGSLFTPQIEYLGLRSEHLASNERGVLELTGRDRRKAVSMLRRLREGEAEYREYRDALQEMLVLNAKAELQVLDDGEGVEGLLRGVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BX00</accession>
    <name>A0A6A7BX00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_198579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FI18188P1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2859245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="304" mass="33171" checksum="9C56880C909B0ABA" modified="2020-06-17" version="1" fragment="single">DGLGPCAATASFLLYALDREILVLHHGSLAIEKRFSLHRQPVRWIQVDNVSDSAGRLAVSYDAGNTAIVWDIWTGAELSRFSSYDRLRAASFMRNGNLAFGNDQGNIILFEHASAEHIAVRTIYDPIAALAPAADCRTFAIGYLNGSILVATVQPFAIVHTLNLNRPPGRIAGLAWHGSSSRQKTEMLATHTADGDLRVWSLPKAPSSDPPTVIRMLQLGDASGARGDCWMNWSKNGRIVQHVAGHTRAWDVRTKKVTWVTLQTPEGLSAMANYGPSSMLFAIRGRDGLVQQYDVNDPALVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXI8</accession>
    <name>A0A6A7BXI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial oxaloacetate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_258298</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="105"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2859950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="306" mass="33579" checksum="4EAE5EBAAE55B022" modified="2020-06-17" version="1">MSTTLGSFVAGGLAACGAVTVTHSFETVKIRLQLQGELQANAPRLYRGVFHGVAVIYANEGMRGLLRGLGCAYCYQMVLNGCRLGFYEPFRKSLNAVLGKDSKYQSVPVNIFAGASSGIMGAMAGSPFFLVKTRLQSYSPFRPVGTQHQYTSAWDGLRKIYSAEGFKGLYRGVGPAMVRTGFGSSVQLPTYFLAKRQLQKHFDMSDGPRLHLLSSAASGVVVCIFMHPPDTVMSRMYNQTGDLYSGAFNCLARTVKTEGVLAVYKGFFAHLARILPHTILTLSFAEQTNRAMRKLEDYIFQKEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXM0</accession>
    <name>A0A6A7BXM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAG-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_217980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005986">
        <property type="protein sequence ID" value="KAF2859954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXM0"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2859954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116602" checksum="17F6D10552CF72B8" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BXX2</accession>
    <name>A0A6A7BXX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">K470DRAFT_258447</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="MU005987">
        <property type="protein sequence ID" value="KAF2859922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BXX2"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="636"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2859922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129656" checksum="24E819AB15D80C6F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYH4</accession>
    <name>A0A6A7BYH4_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Alpha/beta-hydrolase</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">K470DRAFT_258008</name>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="109"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="459" mass="52295" checksum="048465B8348B4548" modified="2020-06-17" version="1">MACCLRLRLRLGLWLSIFFILLELVVRSIILVLPEPVINLFYRLSRRAFHALSPRCSASPSSNPMASAQDFIDLCAIFDCPAEEHIVQTKDGYLLGLHRLGSNRTSDRPVVYLHHGLLMNSEVWMCATTRERCLPIQLHEAGYDVWLGNNRGNKYSKKSLYSVPTEAKFWDFSIDQFAFHDIPDSIDYILSTTGAASLSYIGFSQGSAQAFAALSIHPELNKKVNVFVALAPAMAPPGLSSGVVASLCQSNPEVLYLAFRRKSILGSAPMWSALLDPGIFAYFIDKSLLHLFDWHMHNISQEQKLAAYPHLYSFTSTKCVVHWFQIIRNGTFQMFDDEFTATPWPWLHTAKYYKVPKFPTKNISTPIVLVYGGRDSLVNIDIMKRELPSHTLVRRVDDYEHLDFLWADSLHLKVFPFVREALHRFARLHRERLAIESCDARVDFDHIDSYHVGPQEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BYN3</accession>
    <name>A0A6A7BYN3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
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    </protein>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005988">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BYN3"/>
    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2859819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="268" mass="30134" checksum="188EF38F94AB13FA" modified="2020-06-17" version="1">MSALVATDPTSRLPMELHLEILGELEGHRKYLRRARLVCRTWNIAATEILSRTTSHACLEFISPKERQRFASKTRELTLGGFFSWPYIVDSLRSDSDGSELRFPQLKRLTLGWSSRLSQESTRQFFGPDLKSLTVERMNNQLLTYVPSLCKSLKELQIGVKIPGSGTPIISALLDMVQQLPILESLIVSEFKVDLGEASQYSRFGPSLYRFRTSDAALDSCSVLALARQAGSIFSNVVDLEIRLEDPALVHLPGLFHRLTSLRLTIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZ86</accession>
    <name>A0A6A7BZ86_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZ86"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2860514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="59" mass="6703" checksum="83995800037D7A8D" modified="2020-06-17" version="1">MPGSSKAVTHHCPMRDSGNGKCIKGQTPMGRPYCKKHQYYCPEHTTWTFLKTESCPKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZC9</accession>
    <name>A0A6A7BZC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
        <property type="protein sequence ID" value="KAF2860601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZC9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="140" mass="15153" checksum="DEC8767859182444" modified="2020-06-17" version="1">MSARCPAQQTLLPSQPATNPNHLLFSPYQNQNHSLSLSPPLHSTDTNPKSLQKACTPLSKKTIFSPDALNPSQPGDPACQRLSHNSTMHRNLVIFLIIVLIFVLLTLFGIGIWMLTRPTGAKELGSSTSSSSHSILIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZF8</accession>
    <name>A0A6A7BZF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">K470DRAFT_277212</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005985">
        <property type="protein sequence ID" value="KAF2860099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZF8"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="266"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2860099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="50894" checksum="55A3B3BC5E2DCE89" modified="2020-06-17" version="1">MKLLVGALSSRSASLLSVSGRAFPHRLHIQRHEFSATAPSRIRARYDAYIKQRVTDSDSQPASKQSQHISQAEKDHFDKIEHDSKLQQQRAPWAREGSDVSPADKIKQKGTMTKGKLLTTPSRMLKLILPLTPREVSASRKDVEPLALLVHPQQPLSYLERLIQSELPPLETEGRDRYPNITFRAQNVSNHANAGMEDKDGSTADDDGKTSSDDPHANFVRWSPSTEIGDFIRDASQGKEFEVNIEGASRPIYVGVPSFEDRTYYLRMRLRKIAGQIREKAGLKERLDAMAHRSAQRVAQAGFGGLISWWGVVYYLTFKTELGWDVMEPVTYLVGLSGLIGGYMWFLYHNREVSYQSAMHFTVSRRQHQLYQQHGLNLAQWEMLVEEGNKLRREIKMVADEYDVDWDESQDEGDDSVKKALREAREQQEKKHQEKEGEDRVQEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZN1</accession>
    <name>A0A6A7BZN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_294846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005980">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="122" mass="13782" checksum="86BA818D33ACEE1B" modified="2020-06-17" version="1">MTLAVRGVVDHSRMVNREKELDREILAWSIVHDAISIKLFGHYAVIEGSTQSYYVHRFESLSIDYDKWHRERICSAIDDLTAGVDSNVGQGGLINGISLGEMLAKQVIHPPDFEPDYYSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZS1</accession>
    <name>A0A6A7BZS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_257720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799421">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="93" mass="10584" checksum="E5125DF9BBE4874E" modified="2020-06-17" version="1">MLDRAALCWQEDEITGHDIDTLSGDDGLGINGVGFKPTPAIAQERLARRRRQIFEWKAREAREARQKRIDRRCGRGGEKSHEGPPKRTVRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZT2</accession>
    <name>A0A6A7BZT2_9PEZI</name>
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        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2860714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZT2"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025631208" evidence="2">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2860714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="179" mass="19102" checksum="0C727CD536123084" modified="2020-06-17" version="1">MFPSSFLIVFSVLLSAAAATRDDSAHIASKLLAKVSDKPSAIQTFTTLIKPPSQEQKRAIPNLAALTTLQVSYQKPTPILCKGALQPSSAPTPEVAPTFNPDLMRTTTTDYTTPEVTNALADDTSYLGPDVHKGTTNIVTNPYVTITSFTTIVQGGTTMVEEVLWLTKYTPDATPSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZW3</accession>
    <name>A0A6A7BZW3_9PEZI</name>
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            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_216899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
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    </dbReference>
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        <property type="entry name" value="SelR"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2860602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="191" mass="21515" checksum="75E6C62C8D6280CB" modified="2020-06-17" version="1">MRYSLLRVFIRSLYTLTPGFKRIAPNPINAVSARPIRSITLPFWSALFHTAESRKMSYPVKKSDAEWQAQLSSEQFRVLRQQGTEAPYTGEYDKHFPEKGVYTCAACQAPLYTANQKFKSGCGWPAFFDTVPGAVTRHTDSSFGMERTEIVCSNCGSHLGHVFKGEGYPTPTDERHCVNSVSLKFSDDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7BZY9</accession>
    <name>A0A6A7BZY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005978">
        <property type="protein sequence ID" value="KAF2860774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7BZY9"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2860774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="103" mass="11335" checksum="49024F9198C3B874" modified="2020-06-17" version="1">MLTTFEPSAVSGRRRPKYFECDTTGRMVYAGPYVPPNERSSIMSPTKAQSKRLRNPRPSADRSVRESVHGLVSGSVRGSVRRATVNEGLGAVPPTVDLRFLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0E0</accession>
    <name>A0A6A7C0E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_257323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP-25 family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:Golgi to vacuole transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
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    </dbReference>
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        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2860970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="210" mass="24546" checksum="F90F8FAD1E5384C0" modified="2020-06-17" version="1">MSLQLIADRIKLFLLERERDLLLQLEAKGNHDGEIERSLEQLRIGLDDQPDAKLQRTYEELYERFHGRRPELIFVPFKDLPDEDEDERRKQLFASQEQERYTDQPETQHMNNVQVYERNSEMLQEQDEQLDVLGQSLGRQRMMGIAIGNELDEHNALLDDLEAGVDRHTGRLDRARRRLDDVARKGKGNWSWVTIGVLVAILLLVLFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0M3</accession>
    <name>A0A6A7C0M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_47020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C0M3"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="122"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2861126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="458" mass="51803" checksum="CCD162D41BA5ED81" modified="2020-06-17" version="1">MPPPDSGLLKTKRGERRGKSVERIAGKEEEQHQHQHQPADGARGRAHSNQRAKDKERGGGLFTGSKNVVSKATKGGGNFLVRLGKMGRSSSNAEKEVPDSEYQLKVINRPLAEQARITRISKDLSSCRDKTEYWMPSLPWRCIDYLNSNCESEGLYRIPGGVLQVRHWQRRFDQELDIDLLDEKDLYDPNEIGSVLKKWLTDLPTEMMPLSLQQSLAAELEQENPDFKNIGQPAPQRLRDVLSELPPFNYYLLFAVTCHLSLLLSNQDKNKMDLHNLNICIGPCLKLERWLFNYLVGDWRHCWQGCFTEKQYLEAEKALEQNKILRSNSSPATSRTGSQAPVGSDESVDSSADRVSEDTRDARPRAENKRLVDAFKTRGQQQRDPSPRDRRLPALTARPTTSDCDSEFDTVRGLPSDITRPPLVTRNTHSRSKSDVPPTPSKVAGYPGGDSWFNLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C0Q8</accession>
    <name>A0A6A7C0Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">K470DRAFT_294510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005975">
        <property type="protein sequence ID" value="KAF2861156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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    <sequence length="1635" mass="182698" checksum="8D22E6DBF1278D39" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C0Y7_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="13991" checksum="0C178096BE1D6FC3" modified="2020-06-17" version="1">MTISSVSAANELANNSFSDNTSIKPGDVPQIIHTKANIDPTSKPNADDNADIKDDASSGEEIIYEGFASRIALAQKQEDKEHGQPADNYKRPIWNPFPRVKKVNNALKAGKQGECKDYDPHGGLYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 480.64</strain>
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        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="521" mass="56901" checksum="94EDFAF8539F6F1F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C1N2</accession>
    <name>A0A6A7C1N2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">SLA1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_270020</name>
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    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
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        </location>
    </feature>
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            <begin position="93"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2861411.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="241" mass="25942" checksum="1731B4337DDBCD5B" modified="2020-06-17" version="1">MTKSQQRFYFSPVADESTTSLDTNTTAVDPSQPTIRTVPPPRRVSVAAADQAGDYTSIPLSSGLPVQITDDAQSSTDNDSDGERSEPGKSLPKLPPKTAPEYPPRPWHDLSNTFSLHASLQSVTRDGSLLLSVTNQTPQKTITVSPSKLCSADIAYVEEVTGKTLPPASKVRDLPRPEKVRKWTDASGMYSADAEFGGWLKDRQGVVLHKFNGVRIGVPLERLGKGGKEVVENLGEGVVDG</sequence>
</entry>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="643" mass="72270" checksum="B015EA126117FEE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="158" mass="17866" checksum="CDB3F7947F78FAE2" modified="2020-06-17" version="1" fragment="single">SPLQISDSVRQLLPELHAQGPHFITAHFHERSYLLTQGDTLRLPFVMKGVEPGDVIRLNRASLIGSRDLTLKAAAPPPKLKSRTASTTAITDDTPTKDAQIRLYVCRAVVMGIDSEPMRFLQKTKRRQRKVKVVKSKHKHTILRIKEVRVKSLEEIEA</sequence>
</entry>
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    <reference evidence="1" key="1">
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                <person name="Andreopoulos B."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C1Y8"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2861247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="189" mass="20400" checksum="62B83B2D73F08590" modified="2020-06-17" version="1">MVKSSGDLIFMFECMNMRDIIGTAVVSVLVCLTTLKQLRNEGEGPENLLDAEYWGAEINADSSGFRAAALPMMEGREGDSLGMATRQLPGDVTLESSVDSDDSVVMYVAYPAHQAPGAASAGVFPPNYDGGIVTRLIVMVDDGEESNDDDVLDIDEEQSERKLVMKDTGRDKLIPDKSKGLCWGCSKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C235</accession>
    <name>A0A6A7C235_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_263665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C235"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="227" mass="25174" checksum="3B86064AFBE75672" modified="2020-06-17" version="1">MSSSTTLPHAFPKPFASYLKTKLIYDLDLYEHRVSLTSNRPPLPQPALKLTEIPPPSLNLEINAANLLESLANNLVCSLALNKIHEDTFEETFHYACICDLANSLANDLVAQMLARKLVRVDGVMTCQYMKVLGDEFAGVLEEYRDRTLEGVDGEEQEKRAAKKKKRANKNRNRKLKKKAAKEGMGDNEEDGEGGEEEGGEEDGEGGEEEGGAADEDADDDGEYEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C259</accession>
    <name>A0A6A7C259_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="13" type="ORF">K470DRAFT_214994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="MU005972">
        <property type="protein sequence ID" value="KAF2861453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C259"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="124"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-90)" evidence="10">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2861453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="722" mass="80532" checksum="6B8CE89F191D3C05" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C2Q9</accession>
    <name>A0A6A7C2Q9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_269933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="343" mass="37225" checksum="EE64E254EAAF2DC0" modified="2020-06-17" version="1">MTSLEGQELPMPQEQNSQQLPYGASQPQQAGRNLSQQELEAAQHLIDHSLSNHSADTSQIAVTQRPEGGQRCTNCGTTKTPLWRRAPDGKTICNACGLYYKARNQMRPVDMRRGGPAPDRSSATPPTGLQGQVTFVAADPQQAGTCPGGGRCNGTGGNDSCNGCPAYNNRISKTATLRGNGAANAPGPEVVVACHNCRTTITPLWRRDKDGHPICNACGLYYKLHHNDRPVDMKKDDIQRRKRIMQIDQPAQAAPPVPSVPLAPQPSNGHAHPPHHNSTHPVAPIPIPVDFTDFTSSKRKRAADEGEDPAAKAAKKEQLRRELDHMMNLYIAKERELAALDEG</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2861867.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2862074.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A7C3S9_9PEZI</name>
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            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
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        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
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    <dbReference type="GO" id="GO:0000148">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
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        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1604"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1691"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1703"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1822"/>
            <end position="1846"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
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        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862124.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1905" mass="217728" checksum="CA8C498B75051DBC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C3W5</accession>
    <name>A0A6A7C3W5_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
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        <name evidence="3" type="ORF">K470DRAFT_256239</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
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            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2862276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="349" mass="38361" checksum="C53C7CA7C522CC34" modified="2020-06-17" version="1">MSFNDKVQPALDVIGEALSTDPSDFHDHETWKFHGLGDLLAEATAADLRQQLGLNVSAETFARCPTVGSFRAFLRGEPVDPWEGIPKPKVPLSVVLKGQLDKASTVVFLFPDGSGAGTSYGTLPELGKAVCVVGLNSPFLRQAQQFTCSIEHMARLWLGEVQKLQPNGPYTLGGWSAGGYYAYEAAKLLTASGHKIDRLVLIDSPCRLFYEALPEQVVQQLTEKGLMGASGTKKAPEWLVQHFTSTVGSVDRYMPTPMGVQHVPTHVNMIWVREGLVDNVEQSGLRVDLSVKVTRFLLEPRPELRAEGWEKLVPGATFTYDYMTGNHFQITQPPHSDDLGRILKSLITT</sequence>
</entry>
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    <name>A0A6A7C415_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2861705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="445" mass="50666" checksum="821546EA0A1CDD3A" modified="2020-06-17" version="1">MSSNQNPISNSNHNSNDADLGWDFEADWKTWPEYQHLAMPQLGSPNTAAPQGHPIAGPQINFNDASLLNLNTESLRGPLIDPAWNFTQPPVQHQLQPLLPPPPPQHWSIDPAAPWPSEPFLDQPWSNPRVEPEPNTAQNWNGFIDTAWNAPVGGSSKAVGLIPNWSPSRGTGDLRFQCVKCVKKDPPVKSWYKHTPATGEHHCRRCLEAENKRRMSVHTPHWDYIPSRSGFMNADGAIYARWPSIELDDGRQDDWRLVQNQEEFWVRRFIHAVEAPFQQGLAQQGGEHDEADVKWLQEQQVAINKAQHEKSTAQWFTSEWVTTRLVMLFYAVLNLHRGGRRPYPQGGNNSGFGQIDKRLTCTERLRRVEHLLTLDKRIAINVIDGNHVNALAENPDAVRKRKTLNRKTNVKKAKLQLLGKQEMNKRSRELSEAYLDEDAADEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C428</accession>
    <name>A0A6A7C428_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL Lipase/Acylhydrolase</fullName>
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        <name evidence="2" type="ORF">K470DRAFT_212898</name>
    </gene>
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        <lineage>
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            <taxon>Piedraia</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="671439at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iah1-like"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="271" mass="30180" checksum="1481C71E5D1B182B" modified="2020-06-17" version="1" fragment="single">QMDQIVLFGDSLTQQSFSQVSPDGSPPFGFGAALANAYVRRLDVINRGLSGYNTDQALQCLDQCIPNESRARTKLMTILFGSNDCRIAGSPGTPQTVEVDKFRLNLSNICSQFVNGSHRKIRVVLITPPPIDERKLHRCDMEIFPHLRRDELRRTAENTAKYAQVVRDVGRANNIPVLDLWRAFGARAGYAGDDNSMGSMKRPTNAVLQSMFNDGLHLSGAGNKVVFDELMALIEAKFPDLMPEKLPMAQPAWDDKTWEGVQVERPKTVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C443</accession>
    <name>A0A6A7C443_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_256244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2862281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="543"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="674"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
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            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="271"/>
        </location>
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        </location>
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    </feature>
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        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2862281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="932" mass="102858" checksum="415256D2D6A92CBD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4K3</accession>
    <name>A0A6A7C4K3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">K470DRAFT_7294</name>
    </gene>
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        <name type="scientific">Piedraia hortae CBS 480.64</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Piedraiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2862303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="160" mass="17686" checksum="226E126B073B5D13" modified="2020-06-17" version="1">MYVWARPVENCDEINIRLKTFDNALDCCTYTHASHKAIYVPNSNAMLMYPLHAQVIKQCVQEKCNSFALVVSMASQCPRLQMFSRVGLSHAWPSGQGTSVAGVSPVPSWLYLGEVRAANFGELGIRRGLNVRDSIDPSPASSGVGDRDDRVATWREPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4U3</accession>
    <name>A0A6A7C4U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">K470DRAFT_213368</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2862267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="49016at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
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        <location>
            <begin position="318"/>
            <end position="559"/>
        </location>
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        <location>
            <begin position="565"/>
            <end position="648"/>
        </location>
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        <location>
            <begin position="659"/>
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        </location>
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        <location>
            <begin position="788"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF04811"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2862267.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="924" mass="100727" checksum="1ACD8C322E1A352E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C4Y9</accession>
    <name>A0A6A7C4Y9_9PEZI</name>
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            <fullName evidence="5">tRNA ligase phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">K470DRAFT_255951</name>
    </gene>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="168"/>
        </location>
    </feature>
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            <begin position="173"/>
            <end position="399"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45870" checksum="29E7506A066C1056" modified="2020-06-17" version="1">MATKSKLDRIVLMPVGTIGCGKTTLAATLQKLFGWAHVQNDDVNVKSGKARAFAMSCVQELKSHAAVVADRNNHLRRERDQLMVDVAAKVRTRLVCLHYVHDVANVGRIQRITQARVIERGDNHQTIKMSNGVEQVFDIMKGFIDRFEPVNVKQSPDDQFDLVINLDPCASTADNVEVVLRDMCKAYPGLISNVPNKAAIHAAVRGKHIPSGPALTTQPSTLQVGLSAPKVEQLPRGPPSAFAVQQKLQPPAMKVVYFAVHVPSDRVVQLLDDVFRDVEAQVSDMYRMLKKGNRLQRTFHVTLIHRASSGQHADYWNKLMKQQQLTNGPLGQCRVRMERVVWDSEVMAFVVRLEGRFRSVNNVAHITVGTVSDAVKPAQANVMLDKWLREEGGSDIMVDGVVELEGAAKAFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C517</accession>
    <name>A0A6A7C517_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_175859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
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            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C517"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="126" mass="13806" checksum="5696C71155BC9A25" modified="2020-06-17" version="1">MVFAQSVVPEPFSIGGTEYTYLVDKHRGFSCYFSTQELSAHPRSNSKVPQHSLVAGGSPAPFHIVQDLQPDVSIRLVARSPLPKLSEIPLRYSTEAVCFRVIHAMLIITHEGNANASLPGVCLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5M5</accession>
    <name>A0A6A7C5M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_201940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5M5"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="176" mass="19379" checksum="FFBD739C0A0786DB" modified="2020-06-17" version="1" fragment="single">LSVRQQPCVARACGFGERDRRVIDPPPILELKITSLDGMPEQDPHAILALHCTLVSRDGREDETEAPMQTHLPSTRQLMGTLVASPYQGKDEHGRAGTFFVFPDLSCRSTGVYRLRFKLLRIDPSHMMPGVSSPSVAGITTDPFHVFTAKDFPGMRASSALLKALRRQGLNVGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5U9</accession>
    <name>A0A6A7C5U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">K470DRAFT_255980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005966">
        <property type="protein sequence ID" value="KAF2862345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5U9"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2862345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="127" mass="14552" checksum="5AB41E88C28D749E" modified="2020-06-17" version="1">MEDPTDKTQKVSFRFCRECSNMLYPREDDINSQLMFMCRNCNSSEPAESACVYRNSLKEEIKETAGNIEDVADDPTLPHTDAEPCAKCGTCDAVFFQSQQRTKETGMALFFVCVNCRHQWSTLDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5W0</accession>
    <name>A0A6A7C5W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_275329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5W0"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46733" checksum="8B45361A9EFC8D31" modified="2020-06-17" version="1">MGELVRAFNALPMFDNDPSSSGSGEWVFGFRTTILGQYQEFVFAKELGSQRMLLAGLRRIYAEDSEEIRATLAVELLFRAFVDQKHDPGLPGHEPSHATAPVRWYLGDETLRRPMMDKLRNLDISNGLKTIYETEPTQDDEYNVYWNVVKTASVLAGGHGITGGPNMENCPYCQSGMRPRLASSRIMYCNHRRDVRGCKDGCGTRLRIRHQFECTRQGPINDALRVFTHEAAILAENRVLADDAHIVLPQGSPQFEGFSKPIRRLMRSGLCTPDNMLNLFGRYWTRALGPLMVDIDLTQRLQAAPDSFRQMIDSRLDENLPLQLSQPLNDESMIRRVQSLQTLRVMLLEHLRENDTKRMRYENFVTLFKWTDPLWDSPARAYSLVIQCLNPKHLELQEWERALIAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C5Y4</accession>
    <name>A0A6A7C5Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_255503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005963">
        <property type="protein sequence ID" value="KAF2862986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C5Y4"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="110" mass="12269" checksum="E99283DB6F3369F0" modified="2020-06-17" version="1">MFLHGVVPPPKLKHVVLRGRAERSLLHNSDNQFGSIWMPLKPNILTALGSKIPTLSSVVANISNEAQFTLLESPSIGIRVSEAIRSAAKTFRQCKHLLFIYWLKTDGMCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C635</accession>
    <name>A0A6A7C635_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">K470DRAFT_211941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005964">
        <property type="protein sequence ID" value="KAF2862722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C635"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2862722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="98" mass="10761" checksum="B9E27B165138BA26" modified="2020-06-17" version="1">MSLSSYMNKKVCIITVDGRTLVGTLVACDQVTNVVLNDTVERIVRPADDEEESSEQPHGLYLVRGDNVVVCGLVDEDIDTKIDWTKVRGEAIGSTKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C666</accession>
    <name>A0A6A7C666_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">K470DRAFT_173252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C666"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2862475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="75" mass="8214" checksum="21C0DEAE0474B1AC" modified="2020-06-17" version="1">MSLYGLLVAAAEACEARKPRAATRANIFVLLREAFPRLYRRLLACHFGTAVPDSDVDQVGGFWIGTPCKAECQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C6A5</accession>
    <name>A0A6A7C6A5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_280397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C6A5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
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    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
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        <location>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="16"/>
            <end position="31"/>
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            <dbReference type="PROSITE" id="PS50071"/>
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</entry>
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    <accession>A0A6A7C6F8</accession>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Grigoriev I."/>
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    </dbReference>
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    </evidence>
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    <sequence length="381" mass="41727" checksum="F3E042F7201C57BB" modified="2020-06-17" version="1">MVSKRLIAAYVIDWLTILVIGLATYGLSKTEPRHHVFSLVDLTISYPYIPDSISTLTLVLVALIAPAVIIFLVALIAVPGPRASRGLSRSQVLKLKLWEFEKGWAGLALSVVAAAFITQGSKNAIGKPRPDFLSRCQPDLNNIAAHVATGFAKDLSKDWQMVHSSICLQPDKSVLKDGFKSFPSGHASWSWSGLSYLFLYLCSKFAISIPHLTSENSNLRDEVQNGEDVHASDHPLRIRNTNAAPPVYFLIPAFVPIGTAFYICSTRWAEYYHHGYDLIVGSLIGIFTGWFAFRWYHLPLGRGQGWAWGARSSNRAFGIGVGTGGYVGPEGWGNVVPNSLPKDANRDIEMGRMGPSSSTEESNKTAPLPMTGGYQQGQQFV</sequence>
</entry>
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    <name>A0A6A7C6W9_9PEZI</name>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 480.64</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <property type="protein sequence ID" value="KAF2863316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2863316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="459" mass="52946" checksum="3A1381274E450D75" modified="2020-06-17" version="1">MDDSESRKRENSDYLSVDGSNDGLSTPSLDRSSSTNSDGGFEEFGERVFPPLERLTIFDILENLALPQRLERMQQAMQNQAEKVRRQRTKLTERALSSTNILVGELRKRGVPEEDLKLEKYRQRVKNSVERLSRTWNDAKTVTLKEKITFTLAVMNLIISAYMLGAFPQNFHYWYTAQVLVLIPLRWYKYRQIGFHYFVADLCYFVNVLLLLSIWFFPQSKRLFISVFCLAMGNNAVAIPMWRNSVVFHSLDKVTSVFIHFMPCATLHCIVHLLPVTLQQVRFPAVHTIKYSPPTAPEHYRLKDMILWATLPYAIWQLSYHILITVRKRDKIAAGRPTSFTWLRRSYKNTFLGKLVLSCPEKAQEPAFMAIQYLYALTTILPCPLWFSSLHASGAFLLIVFAWASWNGATYYIDIFGKRLERELETLRVEVARLNGALEGGSRDASRGRKEGKEGVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C758</accession>
    <name>A0A6A7C758_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">K470DRAFT_212627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C758"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="222"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="858"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2862508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128410" checksum="F4822E39612E751A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C779</accession>
    <name>A0A6A7C779_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_212690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU005965">
        <property type="protein sequence ID" value="KAF2862528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C779"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025449385" evidence="6">
        <location>
            <begin position="29"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2862528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="339" mass="37523" checksum="D07975189266DCFB" modified="2020-06-17" version="1">MRVNLPPFTRILLLTVLLLSALNAGLRTQKWNAFAQKSTLAQMSYDYLTSPVWAVPYLVLVPGQSLKFPWTLMTAALIENNVLSLGTSATAVWFGGRYLERSWGTSEFVKFVVFGSVIPNLGAFLVYAVWFTMRKWPEHPTPIQGLIALEAGFLVALKQLVPEHTVSLFKGSIRVRVKHFPAIFTLANIISGPLLGTHTAMWLSLFGFLISWVYLRFFRIMVIESATTGEGTTFKGDASDTFSFVAFFPDVMHPFLSPICDSIYNVLLQLRICTPFSDEAVEAGTQSGRSATLPLRETGRQAEAERRRALALKALDQRLNKLTAVSAEGQSLPGLAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7A9</accession>
    <name>A0A6A7C7A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Squalene/phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_255267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7A9"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35773" checksum="2AE3A9D3C43A9631" modified="2020-06-17" version="1">MSGHRVLTQLKTPNLHKPIIPGCSRKYTQASSTSTSLPLARKFCISTLRQHDTASWILLPYIPPHARDAFISLRVLNLQTAASAGSTPPGTTPPPSSGELIPALRTHYFQNLITSSLSGRSSPQPLSTLLTHAAQTAEWSPHFFTRLLTARSMPPLYPTLNDLEKYAEQTYSSMGYLMLQALGVGSVSADHVASHVGKAEGICAVLRGVPAGLGEGRIALPRDVLVKRGVKEEDVIRRGAEARGLRDAVFEVATRANDNLVAGRRMWEGGRGEGGLEAFLPGVATGLWLERLERVDFDVFHPKLRVTDWRLPWKVWWAWKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7P1</accession>
    <name>A0A6A7C7P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein-like protein subunit beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">K470DRAFT_268439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7P1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2863257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="352" mass="39154" checksum="D008E8A06C454F7B" modified="2020-06-17" version="1">MADVGTESVQQKIQLARRDAEALKDRIKRKKDELADTTLRDVARQRTEALPRLGMKTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLSARDGPARVARELSGHSGYLSCCRFLNDRRILTSSGDMTCVLWDMETGQKLTEFADHLGDVMSLSINPLDNNQFVSGACDAFAKLWDIRLQKCVQTFAAHDSDINAIQFFPNGNAFGTGSDDASCRLFDLRADRELQSYTIGEPLCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGERVGTLQGHDNRVSCLGVSNDAISLCTGSWDSMLRIWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C7S5</accession>
    <name>A0A6A7C7S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">K470DRAFT_211188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005962">
        <property type="protein sequence ID" value="KAF2863119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C7S5"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2863119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="86" mass="9785" checksum="419A92734DF52A6E" modified="2020-06-17" version="1">MADEGSVNEPMDLVRLSLHENVVVKLRGDRELQGRLHAYDTHCNLVLSEVTETVYFVDDDDEVRDLKKQAEMLFVRGDSVVLISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C864</accession>
    <name>A0A6A7C864_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">K470DRAFT_255145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C864"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2863442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="181" mass="18803" checksum="BDE6641BE5805D84" modified="2020-06-17" version="1">MSTGSSGAAAGKPGVPSGKSTGNGDNAKGVIMHTNVGDIVIALYRDQTPKTCRNFATLAATGKYDNVIFHRIIAGFMIQGGDPTGTGRGGSSIYGAKFEDEIVPSLVHKDKGTLSMANSGPNTNGSQFFITLGATPHLNGKHTVFGHVAEGMDVVDKLGAVKTDSNDRPLSPVCIEYCEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8C7</accession>
    <name>A0A6A7C8C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">K470DRAFT_280267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU005961">
        <property type="protein sequence ID" value="KAF2863319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8C7"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="66"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2863319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="774" mass="85065" checksum="B1D18C57003333FA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8S1</accession>
    <name>A0A6A7C8S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_210248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MU005960">
        <property type="protein sequence ID" value="KAF2863637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8S1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Telomerase reverse transcriptase C-terminal extension" evidence="3">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2863637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="449" mass="50538" checksum="20B55A32702A30BE" modified="2020-06-17" version="1">MTKRLRADENERGQKRVKTSNPTPTHPTWPLLQAYYRDVSTLRQFLLSPSAGLPADVRQTIKYCGSSLDDDATLVHLLDSAIVGVPSSPQIAFSQRDLSEHIKQLALLKGEVLQRGRFTQTQIVDFVIWHLIGKDSWNRKYHLLSHGFYSRIASAKGADVQVVPGAPGVLVAHHNPYVEALREHPWTALCRLVGSRADEVLSRLLLQCGVFVPVGMSGNLSQISGIAMYKLKRKSNGEGRGEQTGGVRVHLVSHRMVLRRPALGANGNVVFGLGPKHVLNVYRDLEDSGQTRHVLKFVFPRQFRLQNVFAETSIAYSKAPGHSFRRKTLNALKLQMHAMLLTTEYNKVQTVLYNVHRAFSITAQKSRSLIRALPRQPRDQLIIGQLFHIRNGGIELIVVYPETVEELINLASALIRRRKHIGRQMIPFECEVSRAQVRWCVNPIPFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C8W7</accession>
    <name>A0A6A7C8W7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">K470DRAFT_254254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 480.64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2863944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C8W7"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="249"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2863944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="968" mass="103911" checksum="5CCABD5EE1D26A80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C952</accession>
    <name>A0A6A7C952_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">K470DRAFT_240029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 480.64</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2864034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="277011at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016791">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="282"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="279"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2864034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="474" mass="52053" checksum="30DC89EB4D60231F" modified="2020-06-17" version="1">MNSLNIVSRLTTPPSRSRANSLAVQSGRGASAGDAPATGLDYLVEKLRSPAESPDEQQPGEKVPLLDDGHHEQKPGMRQTVLRIAHGIVFGITALFSAVATPVRRFLAWFYDEDGRLNVTFSAETPRLIVQGRRPKAAGRTTAMKTGSSAGRKASGDERHAAERSGSVDGAASTVTPGSEGDSIAGSKKESYPKESGLGETDMTGEGSRRERKFKSGRVKLLANEDGLRQRKEARARQKSRDFSPELKSPSSESKLSYPRAPASPRPLVPRRQPSYTLPLTNEVPTKTLIIDLDETLIHSMAKGGRMSTGHMVEVRLGGPVSGSGLQIGPGVPILYYVHERPGCHEFLRKACKWYKLVIFTASVQEYADPVIDWLERERKYFSGRYYRQHCTLRNGAYIKDVAQVEPDLSKVMILDNSPISYFFHEDNAIPIEGWISDPTDNDLSNLIPLLEGLQYTTDVRALLALRQGQSLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C983</accession>
    <name>A0A6A7C983_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">K470DRAFT_225265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C983"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2864126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="402" mass="45505" checksum="51FF225DBD8581CC" modified="2020-06-17" version="1" fragment="single">MLLPKGGVSWKAAGARVPPRTVWRFLTQTRVLLALAAASITLLLWNGFSGTAGEMQRFYCFGPAKSPMEMSVNEQARWAGHLQTPVIFNHHAPIEVNNTSIHHLDLNPVQSTTRAVQNEERILILTPLRDAAPYLAQHFDLLAQLTYPHHLIDLAFLVGDSSDDTMATLVSELERVQTGSERLAFRSATVVEKDFGVTLGQDVEDRHGFAAQGPRRKAMGRARNYLLYSALKPDHSWVYWRDVDIVESPKSIIEDFIAHDRDILVPNVWFHRMQDGRDIEGRFDYNSWQESETGRKLAASLDRDVVLAEGYKEYKTDRTYMARMGDWRDNKDFEIPLDGIGGVNILVKADVHRSGINFPCYAFENQAETEGFAKMARRAGYGVYGLPNYVVWHIDTEEKPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9L7</accession>
    <name>A0A6A7C9L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial porin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">K470DRAFT_279888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9L7"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2864083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30239" checksum="20BC974030312EDC" modified="2020-06-17" version="1">MPVPAYGDVAKAANDLITRDFYHTAQATLDVKLKAPNGTNVTVKGKQGFDGVTSGSLEGKHTLKPQGVTITQAWNTASLLDTKVELADVVAPGAKIDLQNLWNPSKPSSAAQKLTMAFKNPNVHSRAFLNYAQSSGNIDAIVDVVAGHEGFLVGGEAAYDVQKAAVTRYGLAVAYSTPTYTASLQGIQNLSMVMASFYQKVNNAVEVGAKAGYDVRSSKASGLELASKYKLDSMSFAKAKINDRGIAAFAYSTKLNPGTTLGLGLSLDTQKLNEAGHKIGTSLTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7C9Q9</accession>
    <name>A0A6A7C9Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">K470DRAFT_254571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005958">
        <property type="protein sequence ID" value="KAF2864251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7C9Q9"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="86"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2864251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799421"/>
        </source>
    </evidence>
    <sequence length="348" mass="37358" checksum="79C440EA863D25FE" modified="2020-06-17" version="1">MSPPPPPPPPPQQASLVSYLTHPISYSFTSLARRLSYEGEDSHTSLVAQALAAPSVPMAAIPRKLSPFQPPPLTPLTFSATGASAPILSHALGEEIRLLLPPRLQLVESWTLAYSLDRDGSALSTLYTHCDALGSGKRAGWVLVVKDADKNVFGAYLSDFPKAHPSYYGNGECFLWRTVQMRRESRSQSTPPQNIAAPPVDLLGDDDDLMSFLPPPPSADTEHLNLGRLTTFQGSRPSTPASRGSRSATPAGKTVDGGVCLPPKTPAQKKQGQTLRFKAFPYTGTNDFNIFCQADYLSVGGGDGHYGLWLDGSLSHGVSDTSLTFCNEPLSEMGNGFDVLSVEVWFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A7CA19</accession>
    <name>A0A6A7CA19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">K470DRAFT_267229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Piedraia hortae CBS 480.64</name>
        <dbReference type="NCBI Taxonomy" id="1314780"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Capnodiales</taxon>
            <taxon>Piedraiaceae</taxon>
            <taxon>Piedraia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 480.64</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU005957">
        <property type="protein sequence ID" value="KAF2864371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A7CA19"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799421">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <sour